FAM134A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.53371123
2L-phenylalanine catabolic process (GO:0006559)5.53371123
3L-phenylalanine metabolic process (GO:0006558)5.26650105
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.26650105
5aromatic amino acid family catabolic process (GO:0009074)4.67696071
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.60609085
7alpha-linolenic acid metabolic process (GO:0036109)4.37951681
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.30838586
9bile acid biosynthetic process (GO:0006699)4.17509230
10kynurenine metabolic process (GO:0070189)4.02470493
11urea cycle (GO:0000050)3.99923697
12urea metabolic process (GO:0019627)3.99923697
13cysteine metabolic process (GO:0006534)3.95864725
14glyoxylate metabolic process (GO:0046487)3.95428258
15indole-containing compound catabolic process (GO:0042436)3.91061382
16indolalkylamine catabolic process (GO:0046218)3.91061382
17tryptophan catabolic process (GO:0006569)3.91061382
18high-density lipoprotein particle remodeling (GO:0034375)3.88637426
19glutamate metabolic process (GO:0006536)3.85713424
20sulfur amino acid catabolic process (GO:0000098)3.83420883
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.78122307
22regulation of ARF protein signal transduction (GO:0032012)3.72401472
23cellular potassium ion homeostasis (GO:0030007)3.70647413
24peptidyl-glutamic acid carboxylation (GO:0017187)3.68589649
25protein carboxylation (GO:0018214)3.68589649
26lysine catabolic process (GO:0006554)3.63469449
27lysine metabolic process (GO:0006553)3.63469449
28nitrogen cycle metabolic process (GO:0071941)3.63412271
29dicarboxylic acid biosynthetic process (GO:0043650)3.62197827
30negative regulation of fibrinolysis (GO:0051918)3.61506608
31tryptophan metabolic process (GO:0006568)3.61300444
32cellular ketone body metabolic process (GO:0046950)3.57470534
33sodium ion export (GO:0071436)3.57007599
34bile acid metabolic process (GO:0008206)3.55660170
35complement activation, alternative pathway (GO:0006957)3.52507779
36protein localization to endosome (GO:0036010)3.50521772
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.43641016
38reverse cholesterol transport (GO:0043691)3.43475783
39regulation of fibrinolysis (GO:0051917)3.39613097
40regulation of protein activation cascade (GO:2000257)3.38384891
41drug catabolic process (GO:0042737)3.37440222
42serine family amino acid catabolic process (GO:0009071)3.34845400
43aromatic amino acid family metabolic process (GO:0009072)3.30776765
44amino-acid betaine metabolic process (GO:0006577)3.28760446
45synaptic vesicle maturation (GO:0016188)3.27012374
46protein-lipid complex remodeling (GO:0034368)3.25932739
47macromolecular complex remodeling (GO:0034367)3.25932739
48plasma lipoprotein particle remodeling (GO:0034369)3.25932739
49cellular modified amino acid catabolic process (GO:0042219)3.25925819
50alpha-amino acid catabolic process (GO:1901606)3.25690740
51negative regulation of sterol transport (GO:0032372)3.23923835
52negative regulation of cholesterol transport (GO:0032375)3.23923835
53regulation of short-term neuronal synaptic plasticity (GO:0048172)3.23644367
54positive regulation of Rap GTPase activity (GO:0032854)3.22747769
55tyrosine metabolic process (GO:0006570)3.21143679
56regulation of cholesterol esterification (GO:0010872)3.19798969
57gamma-aminobutyric acid transport (GO:0015812)3.17618066
58negative regulation of erythrocyte differentiation (GO:0045647)3.15923053
59regulation of complement activation (GO:0030449)3.15506678
60regulation of cholesterol homeostasis (GO:2000188)3.14371661
61phospholipid efflux (GO:0033700)3.13756758
62coenzyme catabolic process (GO:0009109)3.13498540
63G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.13217268
64triglyceride homeostasis (GO:0070328)3.10615364
65acylglycerol homeostasis (GO:0055090)3.10615364
66ketone body metabolic process (GO:1902224)3.09565845
67cellular amino acid catabolic process (GO:0009063)3.09498614
68locomotory exploration behavior (GO:0035641)3.09088993
69homocysteine metabolic process (GO:0050667)3.08900233
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08827877
71exogenous drug catabolic process (GO:0042738)3.06991756
72regulation of triglyceride catabolic process (GO:0010896)3.06822655
73cholesterol efflux (GO:0033344)3.06080902
74drug transmembrane transport (GO:0006855)3.05103159
75plasma lipoprotein particle clearance (GO:0034381)3.02678188
76short-chain fatty acid metabolic process (GO:0046459)3.01784988
77glutamate secretion (GO:0014047)3.01044193
78aspartate family amino acid catabolic process (GO:0009068)2.97051067
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.94423961
80cerebellar granule cell differentiation (GO:0021707)2.88634921
81bile acid and bile salt transport (GO:0015721)2.88543063
82regulation of synaptic vesicle transport (GO:1902803)2.87028786
83neurotransmitter secretion (GO:0007269)2.85951984
84negative regulation of lipase activity (GO:0060192)2.85798389
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85290236
86dicarboxylic acid catabolic process (GO:0043649)2.84956464
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.84068407
88regulation of amyloid precursor protein catabolic process (GO:1902991)2.82332566
89negative regulation of cell killing (GO:0031342)2.80572021
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80572021
91positive regulation of fibroblast migration (GO:0010763)2.79307602
92synaptic vesicle exocytosis (GO:0016079)2.77011280
93L-amino acid import (GO:0043092)2.76435425
94ethanol oxidation (GO:0006069)2.75094248
952-oxoglutarate metabolic process (GO:0006103)2.75056452
96indolalkylamine metabolic process (GO:0006586)2.74916874
97signal complex assembly (GO:0007172)2.74157548
98regulation of Rap GTPase activity (GO:0032317)2.73957457
99regulation of early endosome to late endosome transport (GO:2000641)2.73897224
100plasma lipoprotein particle assembly (GO:0034377)2.73594375
101regulation of beta-amyloid formation (GO:1902003)2.73287381
102positive regulation of lipid catabolic process (GO:0050996)2.73045146
103benzene-containing compound metabolic process (GO:0042537)2.72621218
104regulation of cholesterol biosynthetic process (GO:0045540)2.68718515
105negative regulation of dendrite morphogenesis (GO:0050774)2.68104502
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67600535
107regulation of neuronal synaptic plasticity (GO:0048168)2.65475301
108organic acid catabolic process (GO:0016054)2.64729123
109carboxylic acid catabolic process (GO:0046395)2.64729123
110arginine metabolic process (GO:0006525)2.64531819
111sterol catabolic process (GO:0016127)2.64355671
112cholesterol catabolic process (GO:0006707)2.64355671
113cofactor catabolic process (GO:0051187)2.62715177
114regulation of extracellular matrix disassembly (GO:0010715)2.62238506
115very long-chain fatty acid metabolic process (GO:0000038)2.61194543
116low-density lipoprotein particle remodeling (GO:0034374)2.60613068
117neurotransmitter-gated ion channel clustering (GO:0072578)2.60419101
118cellular glucuronidation (GO:0052695)2.60340687
119pyrimidine nucleobase catabolic process (GO:0006208)2.58726128
120layer formation in cerebral cortex (GO:0021819)2.58725394
121acetyl-CoA metabolic process (GO:0006084)2.57475608
122regulation of synaptic vesicle exocytosis (GO:2000300)2.56881152
123protein-lipid complex assembly (GO:0065005)2.56835585
124serine family amino acid metabolic process (GO:0009069)2.56192982
125activation of protein kinase A activity (GO:0034199)2.55428635
126positive regulation of protein dephosphorylation (GO:0035307)2.54099007
127imidazole-containing compound metabolic process (GO:0052803)2.53833165
128positive regulation of fatty acid biosynthetic process (GO:0045723)2.53466791
129antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52352275
130amino acid import (GO:0043090)2.52013681
131potassium ion homeostasis (GO:0055075)2.50700737
132regulation of regulated secretory pathway (GO:1903305)2.50524389
133regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46401650
134peptidyl-tyrosine autophosphorylation (GO:0038083)2.43567607
135cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.42805526
136regulation of synaptic plasticity (GO:0048167)2.39762266
137positive regulation of cellular amide metabolic process (GO:0034250)2.39069691
138positive regulation of synapse maturation (GO:0090129)2.38493820
139antigen processing and presentation of endogenous antigen (GO:0019883)2.34535736
140exploration behavior (GO:0035640)2.33894973
141positive regulation of receptor recycling (GO:0001921)2.31919881
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.31891981
143regulation of ARF GTPase activity (GO:0032312)2.29826462
144potassium ion import (GO:0010107)2.28962054
145regulation of leukocyte degranulation (GO:0043300)2.28561245
146myelin maintenance (GO:0043217)2.26597955
147positive regulation of neurotransmitter secretion (GO:0001956)2.25430638
148regulation of glutamate receptor signaling pathway (GO:1900449)2.25338621
149neuromuscular process controlling balance (GO:0050885)2.23089000
150protein targeting to plasma membrane (GO:0072661)2.22957235
151regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.22942111
152positive thymic T cell selection (GO:0045059)2.21930086
153regulation of T-helper 2 cell differentiation (GO:0045628)2.21736543
154dopamine receptor signaling pathway (GO:0007212)2.20220792
155membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.19266471
156mannose metabolic process (GO:0006013)2.18717413
157regulation of myeloid leukocyte mediated immunity (GO:0002886)2.18411001
158ionotropic glutamate receptor signaling pathway (GO:0035235)2.18148238
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.18114528
160cellular response to monoamine stimulus (GO:0071868)2.16061698
161cellular response to catecholamine stimulus (GO:0071870)2.16061698
162regulation of cellular amide metabolic process (GO:0034248)2.15453209
163neurotransmitter transport (GO:0006836)2.14957895
164dendritic spine morphogenesis (GO:0060997)2.13633365
165macroautophagy (GO:0016236)2.13395367
166barbed-end actin filament capping (GO:0051016)2.12063117
167positive regulation of neurotransmitter transport (GO:0051590)2.10398843
168regulation of defense response to virus by virus (GO:0050690)2.09476008
169long-term synaptic potentiation (GO:0060291)2.08254860
170synaptic vesicle endocytosis (GO:0048488)2.07192895
171regulation of protein dephosphorylation (GO:0035304)2.06854330
172positive regulation of regulated secretory pathway (GO:1903307)2.06663225
173mating behavior (GO:0007617)2.06333638
174cellular sodium ion homeostasis (GO:0006883)2.06121804
175neuronal ion channel clustering (GO:0045161)2.05645797
176negative regulation of type 2 immune response (GO:0002829)2.05583589
177actin filament capping (GO:0051693)2.01969799
178neuromuscular process controlling posture (GO:0050884)2.01445446
179regulation of exocytosis (GO:0017157)1.99954983
180transferrin transport (GO:0033572)1.99255278
181stress fiber assembly (GO:0043149)1.98737696
182long-term memory (GO:0007616)1.98536714
183macrophage activation involved in immune response (GO:0002281)1.98524453
184cell communication by electrical coupling (GO:0010644)1.97539817
185adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)1.95994526
186detection of other organism (GO:0098543)1.94785905
187response to monoamine (GO:0071867)1.93824345
188response to catecholamine (GO:0071869)1.93824345
189positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.93683741
190dendritic spine organization (GO:0097061)1.93151022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.54076930
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.70040558
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.92587880
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.73496090
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.17156534
6EZH2_22144423_ChIP-Seq_EOC_Human3.06369128
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.72052551
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61057069
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.46799892
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33159206
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10709805
12RARB_27405468_Chip-Seq_BRAIN_Mouse1.95656595
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92392425
14REST_21632747_ChIP-Seq_MESCs_Mouse1.92270491
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.88013559
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86598732
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85110398
18TCF7_22412390_ChIP-Seq_EML_Mouse1.84744929
19DROSHA_22980978_ChIP-Seq_HELA_Human1.82609492
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80858865
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.79373482
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79298254
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.76461936
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76287367
25RACK7_27058665_Chip-Seq_MCF-7_Human1.76211075
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75578032
27VDR_21846776_ChIP-Seq_THP-1_Human1.74971037
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72978971
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72380645
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72370730
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69745288
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.69649578
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60215217
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55371836
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54016820
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.51147942
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49881657
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49881657
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48403704
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47747393
41LXR_22292898_ChIP-Seq_THP-1_Human1.47408783
42* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46004926
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45884056
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43989720
45VDR_24763502_ChIP-Seq_THP-1_Human1.43469336
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41455128
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40949362
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40735870
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38953005
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37102230
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36805667
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.34701004
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34215883
54GBX2_23144817_ChIP-Seq_PC3_Human1.34097898
55ZNF263_19887448_ChIP-Seq_K562_Human1.32864144
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32814485
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.32576087
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.32321374
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28928383
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27723015
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.26713839
62GATA1_22025678_ChIP-Seq_K562_Human1.26411562
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24721070
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24238030
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24094860
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22023814
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20825255
68MYC_22102868_ChIP-Seq_BL_Human1.20402866
69KDM2B_26808549_Chip-Seq_K562_Human1.19353506
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19300376
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18262477
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.18183634
73SPI1_23127762_ChIP-Seq_K562_Human1.17902587
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.17390684
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.16759560
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14749728
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14096885
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13356077
79* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11899302
80CTCF_27219007_Chip-Seq_Bcells_Human1.11314730
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11233934
82GATA1_19941826_ChIP-Seq_K562_Human1.11143457
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09990682
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08566631
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05981329
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05191496
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.05126208
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03839842
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.03616099
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01858938
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01552025
92MAF_26560356_Chip-Seq_TH1_Human1.01458384
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01281741
94* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01269290
95SCL_19346495_ChIP-Seq_HPC-7_Human1.00636976
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.00190625
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99848662
98IRF8_27001747_Chip-Seq_BMDM_Mouse0.99010962
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98919275
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.98715807
101EZH2_27304074_Chip-Seq_ESCs_Mouse0.98095164
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96747259
103SMC4_20622854_ChIP-Seq_HELA_Human0.96092554
104* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95288293
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95202738
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95166945
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94959183
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94883172
109BCOR_27268052_Chip-Seq_Bcells_Human0.94072952
110UTX_26944678_Chip-Seq_JUKART_Human0.93848424
111ESR2_21235772_ChIP-Seq_MCF-7_Human0.89940550
112CREB1_26743006_Chip-Seq_LNCaP_Human0.89820616
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89347840
114* TET1_21490601_ChIP-Seq_MESCs_Mouse0.87516001
115* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86810752
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86113774
117HNF4A_19822575_ChIP-Seq_HepG2_Human0.85867562
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85519078
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85126109
120KLF4_19829295_ChIP-Seq_ESCs_Human0.83654848
121HTT_18923047_ChIP-ChIP_STHdh_Human0.82143108
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.80543759
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77662797
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75801595
125ZNF274_21170338_ChIP-Seq_K562_Hela0.72491036
126GATA2_19941826_ChIP-Seq_K562_Human0.72371756
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.71739236
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71348551
129SOX2_21211035_ChIP-Seq_LN229_Gbm0.71274204
130AR_19668381_ChIP-Seq_PC3_Human0.71159032
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.70019212
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69893155
133SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69625540
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.69600790
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69476987
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.68275082
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.67235354
138KDM2B_26808549_Chip-Seq_DND41_Human0.67155125
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.66819185
140SA1_27219007_Chip-Seq_Bcells_Human0.66692158
141MYC_19915707_ChIP-ChIP_AK7_Human0.66218091
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66143548
143RXRA_24833708_ChIP-Seq_LIVER_Mouse0.65966208
144CLOCK_20551151_ChIP-Seq_293T_Human0.65730652
145MYC_27129775_Chip-Seq_CORNEA_Mouse0.65539828
146AR_21572438_ChIP-Seq_LNCaP_Human0.65348514
147CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.64510488
148P68_20966046_ChIP-Seq_HELA_Human0.64441042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.10358834
2MP0005360_urolithiasis5.34026655
3MP0005085_abnormal_gallbladder_physiolo4.47950611
4MP0005365_abnormal_bile_salt4.39314457
5MP0004859_abnormal_synaptic_plasticity3.71552849
6MP0008875_abnormal_xenobiotic_pharmacok3.70112585
7MP0010329_abnormal_lipoprotein_level2.83310210
8MP0003252_abnormal_bile_duct2.71639936
9MP0005083_abnormal_biliary_tract2.54113863
10MP0003195_calcinosis2.52506297
11MP0009840_abnormal_foam_cell2.37766205
12MP0003329_amyloid_beta_deposits2.31162386
13MP0003635_abnormal_synaptic_transmissio2.29841854
14MP0003303_peritoneal_inflammation2.27792678
15MP0002822_catalepsy2.17444321
16MP0005409_darkened_coat_color2.08910178
17MP0005332_abnormal_amino_acid2.07757536
18MP0003705_abnormal_hypodermis_morpholog2.04459600
19MP0001666_abnormal_nutrient_absorption1.96237017
20MP0004270_analgesia1.88743293
21MP0003191_abnormal_cellular_cholesterol1.87049348
22MP0003880_abnormal_central_pattern1.86336675
23MP0003183_abnormal_peptide_metabolism1.85811761
24MP0008260_abnormal_autophagy1.85391430
25MP0002118_abnormal_lipid_homeostasis1.83258652
26MP0009745_abnormal_behavioral_response1.83224719
27MP0000604_amyloidosis1.82122401
28MP0002064_seizures1.82090532
29MP0002909_abnormal_adrenal_gland1.80148552
30MP0002063_abnormal_learning/memory/cond1.79618689
31MP0003436_decreased_susceptibility_to1.73516039
32MP0003806_abnormal_nucleotide_metabolis1.73443768
33MP0003300_gastrointestinal_ulcer1.67548979
34MP0009046_muscle_twitch1.57008788
35MP0005584_abnormal_enzyme/coenzyme_acti1.54173646
36MP0004019_abnormal_vitamin_homeostasis1.50081701
37MP0003656_abnormal_erythrocyte_physiolo1.49711226
38MP0001958_emphysema1.48878690
39MP0003868_abnormal_feces_composition1.48743357
40MP0004043_abnormal_pH_regulation1.48022414
41MP0000609_abnormal_liver_physiology1.47710100
42MP0009780_abnormal_chondrocyte_physiolo1.45674958
43MP0001501_abnormal_sleep_pattern1.44512819
44MP0005464_abnormal_platelet_physiology1.41686413
45MP0002572_abnormal_emotion/affect_behav1.41586474
46MP0002272_abnormal_nervous_system1.37166656
47MP0003634_abnormal_glial_cell1.36874749
48MP0001968_abnormal_touch/_nociception1.35057925
49MP0003690_abnormal_glial_cell1.33041018
50MP0005535_abnormal_body_temperature1.32705793
51MP0003724_increased_susceptibility_to1.31914010
52MP0003879_abnormal_hair_cell1.28466338
53MP0004381_abnormal_hair_follicle1.25115743
54MP0005319_abnormal_enzyme/_coenzyme1.24838009
55MP0008961_abnormal_basal_metabolism1.22513815
56MP0003075_altered_response_to1.21933758
57MP0004858_abnormal_nervous_system1.19531938
58MP0002138_abnormal_hepatobiliary_system1.17968894
59MP0001348_abnormal_lacrimal_gland1.17907546
60MP0003045_fibrosis1.17689367
61MP0001440_abnormal_grooming_behavior1.16448115
62MP0003633_abnormal_nervous_system1.16281142
63MP0002419_abnormal_innate_immunity1.16076993
64MP0001486_abnormal_startle_reflex1.14532886
65MP0003123_paternal_imprinting1.12812547
66MP0005423_abnormal_somatic_nervous1.11722881
67MP0001533_abnormal_skeleton_physiology1.11704342
68MP0003866_abnormal_defecation1.11643432
69MP0003172_abnormal_lysosome_physiology1.10689050
70MP0002998_abnormal_bone_remodeling1.09707940
71MP0002734_abnormal_mechanical_nocicepti1.08840621
72MP0000685_abnormal_immune_system1.08801438
73MP0005058_abnormal_lysosome_morphology1.07558912
74MP0004885_abnormal_endolymph1.06896819
75MP0002736_abnormal_nociception_after1.06557868
76MP0000015_abnormal_ear_pigmentation1.06295656
77MP0005636_abnormal_mineral_homeostasis1.05704577
78MP0001984_abnormal_olfaction1.05625933
79MP0005025_abnormal_response_to1.04552474
80MP0002078_abnormal_glucose_homeostasis1.04317466
81MP0002733_abnormal_thermal_nociception1.04237373
82MP0004947_skin_inflammation1.02249235
83MP0008569_lethality_at_weaning1.02141290
84MP0009643_abnormal_urine_homeostasis1.01973551
85MP0008874_decreased_physiological_sensi1.01546642
86MP0004130_abnormal_muscle_cell1.00499527
87MP0009278_abnormal_bone_marrow0.99833294
88MP0008438_abnormal_cutaneous_collagen0.99058969
89MP0008872_abnormal_physiological_respon0.98782484
90MP0002090_abnormal_vision0.97063206
91MP0002877_abnormal_melanocyte_morpholog0.96511855
92MP0001764_abnormal_homeostasis0.94772899
93MP0003632_abnormal_nervous_system0.94669559
94MP0001502_abnormal_circadian_rhythm0.94369820
95MP0001849_ear_inflammation0.93824689
96MP0005000_abnormal_immune_tolerance0.93587765
97MP0003122_maternal_imprinting0.93018149
98MP0002735_abnormal_chemical_nociception0.92912762
99MP0010234_abnormal_vibrissa_follicle0.92683306
100MP0001851_eye_inflammation0.89322348
101MP0001765_abnormal_ion_homeostasis0.88959820
102MP0005167_abnormal_blood-brain_barrier0.88706163
103MP0002067_abnormal_sensory_capabilities0.88516874
104MP0002876_abnormal_thyroid_physiology0.88330751
105MP0000681_abnormal_thyroid_gland0.88160988
106MP0001970_abnormal_pain_threshold0.87939319
107MP0004811_abnormal_neuron_physiology0.87770564
108MP0002089_abnormal_postnatal_growth/wei0.87569183
109MP0002229_neurodegeneration0.86795865
110MP0003091_abnormal_cell_migration0.86734307
111MP0003631_nervous_system_phenotype0.86191454
112MP0002557_abnormal_social/conspecific_i0.83084838
113MP0005387_immune_system_phenotype0.82857552
114MP0001790_abnormal_immune_system0.82857552
115MP0001905_abnormal_dopamine_level0.82380049
116MP0001835_abnormal_antigen_presentation0.81673225
117MP0006082_CNS_inflammation0.80550596
118MP0003566_abnormal_cell_adhesion0.79885151
119MP0000955_abnormal_spinal_cord0.79533450
120MP0000920_abnormal_myelination0.79512701
121MP0002069_abnormal_eating/drinking_beha0.79050317
122MP0005448_abnormal_energy_balance0.78850602
123MP0002066_abnormal_motor_capabilities/c0.78452814
124MP0003453_abnormal_keratinocyte_physiol0.76916476
125MP0005386_behavior/neurological_phenoty0.75151436
126MP0004924_abnormal_behavior0.75151436
127MP0009642_abnormal_blood_homeostasis0.74985951
128MP0003787_abnormal_imprinting0.74519754
129MP0005646_abnormal_pituitary_gland0.73907438
130MP0003953_abnormal_hormone_level0.73711782
131MP0003279_aneurysm0.72230071
132MP0002420_abnormal_adaptive_immunity0.72183029
133MP0004510_myositis0.71583843
134MP0005410_abnormal_fertilization0.70552757
135MP0001756_abnormal_urination0.70416932
136MP0005551_abnormal_eye_electrophysiolog0.70099467
137MP0000639_abnormal_adrenal_gland0.70031520
138MP0001819_abnormal_immune_cell0.69892519
139MP0003011_delayed_dark_adaptation0.69615395
140MP0005451_abnormal_body_composition0.66335589
141MP0005166_decreased_susceptibility_to0.64169763
142MP0005076_abnormal_cell_differentiation0.62859383
143MP0004142_abnormal_muscle_tone0.62714270
144MP0003638_abnormal_response/metabolism_0.62503352
145MP0000598_abnormal_liver_morphology0.61841775
146MP0006036_abnormal_mitochondrial_physio0.61819643
147MP0005334_abnormal_fat_pad0.61593268

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.55023555
2Deep venous thrombosis (HP:0002625)5.24186624
3Intrahepatic cholestasis (HP:0001406)4.65454572
4Xanthomatosis (HP:0000991)4.43351619
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.18772359
6Hyperlipoproteinemia (HP:0010980)4.03455534
7Prolonged partial thromboplastin time (HP:0003645)4.00538669
8Hypobetalipoproteinemia (HP:0003563)3.80916380
9Complement deficiency (HP:0004431)3.70647008
10Myokymia (HP:0002411)3.64405690
11Ketosis (HP:0001946)3.60443206
12Diplopia (HP:0000651)3.37053515
13Abnormality of binocular vision (HP:0011514)3.37053515
14Obstructive sleep apnea (HP:0002870)3.32115646
15Visual hallucinations (HP:0002367)3.13649779
16Abnormality of the common coagulation pathway (HP:0010990)3.06763213
17Hyperammonemia (HP:0001987)3.05733909
18Neurofibrillary tangles (HP:0002185)3.04661761
19Gout (HP:0001997)2.98458037
20Ketoacidosis (HP:0001993)2.94615506
21Epidermoid cyst (HP:0200040)2.93221398
22Dysostosis multiplex (HP:0000943)2.91878704
23Hyperglycinemia (HP:0002154)2.91577725
24Focal motor seizures (HP:0011153)2.91311685
25Abnormality of glutamine family amino acid metabolism (HP:0010902)2.89777309
26Cerebral inclusion bodies (HP:0100314)2.89072074
27Supranuclear gaze palsy (HP:0000605)2.85640517
28Abnormality of glycolipid metabolism (HP:0010969)2.84524521
29Abnormality of liposaccharide metabolism (HP:0010968)2.84524521
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.84524521
31Hypolipoproteinemia (HP:0010981)2.82152939
32Abnormal gallbladder physiology (HP:0012438)2.80709895
33Cholecystitis (HP:0001082)2.80709895
34Status epilepticus (HP:0002133)2.79333279
35Joint hemorrhage (HP:0005261)2.73844576
36Abnormality of the lower motor neuron (HP:0002366)2.72591165
37Eczematoid dermatitis (HP:0000976)2.72237255
38Hyperbilirubinemia (HP:0002904)2.70868454
39Delayed CNS myelination (HP:0002188)2.61449693
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.61088287
41Fat malabsorption (HP:0002630)2.59075376
42Abnormality of glycine metabolism (HP:0010895)2.58262274
43Abnormality of serine family amino acid metabolism (HP:0010894)2.58262274
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.58133722
45Urinary glycosaminoglycan excretion (HP:0003541)2.55677376
46Mucopolysacchariduria (HP:0008155)2.55677376
47Hypoglycemic coma (HP:0001325)2.55262407
48Hypoalphalipoproteinemia (HP:0003233)2.55087404
49Abnormality of the intrinsic pathway (HP:0010989)2.52889990
50Abnormality of complement system (HP:0005339)2.52792187
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52460014
52Abnormality of polysaccharide metabolism (HP:0011012)2.52460014
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52460014
54Focal seizures (HP:0007359)2.48158069
55Torticollis (HP:0000473)2.46549024
56Papilledema (HP:0001085)2.46092974
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44920898
58Hypercholesterolemia (HP:0003124)2.41195758
59Hyperglycinuria (HP:0003108)2.41181544
60Vertebral compression fractures (HP:0002953)2.40959206
61Cerebral aneurysm (HP:0004944)2.39766043
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37990771
63Focal dystonia (HP:0004373)2.37505499
64Postural instability (HP:0002172)2.36249814
65Ocular albinism (HP:0001107)2.35809860
66Conjugated hyperbilirubinemia (HP:0002908)2.35165881
67Abnormality of macrophages (HP:0004311)2.35003468
68Increased cerebral lipofuscin (HP:0011813)2.34063182
69Global brain atrophy (HP:0002283)2.33642485
70Abnormal gallbladder morphology (HP:0012437)2.33294003
71Craniofacial dystonia (HP:0012179)2.33174051
72Slow saccadic eye movements (HP:0000514)2.31173508
73Cholelithiasis (HP:0001081)2.29337256
74Sensorimotor neuropathy (HP:0007141)2.27457918
75Abnormality of the Achilles tendon (HP:0005109)2.27416936
76Abnormality of purine metabolism (HP:0004352)2.26344246
77Amyloidosis (HP:0011034)2.24909978
78Action tremor (HP:0002345)2.24496966
79Neonatal onset (HP:0003623)2.23273260
80Hypercortisolism (HP:0001578)2.22053328
81Abnormality of methionine metabolism (HP:0010901)2.20866867
82Depression (HP:0000716)2.19831965
83Irritability (HP:0000737)2.18983181
84Acanthocytosis (HP:0001927)2.18497437
85Abnormal social behavior (HP:0012433)2.17980712
86Impaired social interactions (HP:0000735)2.17980712
87Generalized tonic-clonic seizures (HP:0002069)2.17304327
88Recurrent abscess formation (HP:0002722)2.14907817
89Abnormality of fatty-acid metabolism (HP:0004359)2.14399587
90Purpura (HP:0000979)2.14195472
91Intention tremor (HP:0002080)2.11856220
92Akinesia (HP:0002304)2.11845262
93Hyperparathyroidism (HP:0000843)2.11729843
94Skin nodule (HP:0200036)2.10743152
95Annular pancreas (HP:0001734)2.10402009
96Hyperventilation (HP:0002883)2.09443475
97Growth hormone excess (HP:0000845)2.09374975
98Hypoglycemic seizures (HP:0002173)2.09340376
99Protrusio acetabuli (HP:0003179)2.07994700
100Anxiety (HP:0000739)2.06039569
101Mutism (HP:0002300)2.05666385
102Tetraplegia (HP:0002445)2.05146420
103Abnormal eating behavior (HP:0100738)2.04780953
104Loss of speech (HP:0002371)2.03200791
105Late onset (HP:0003584)2.02086181
106Rigidity (HP:0002063)2.01326162
107Cellulitis (HP:0100658)2.00330265
108Death in childhood (HP:0003819)2.00101859
109Absence seizures (HP:0002121)1.99940973
110Increased neuronal autofluorescent lipopigment (HP:0002074)1.99403886
111Poikilocytosis (HP:0004447)1.99003343
112Peripheral hypomyelination (HP:0007182)1.98972541
113Hepatocellular carcinoma (HP:0001402)1.98645387
114Apathy (HP:0000741)1.98501824
115Iris hypopigmentation (HP:0007730)1.97815112
116Poor eye contact (HP:0000817)1.97664964
117Abnormality of nucleobase metabolism (HP:0010932)1.96126587
118Spastic tetraparesis (HP:0001285)1.95921305
119Alkalosis (HP:0001948)1.95052669
120Dysdiadochokinesis (HP:0002075)1.94974845
121Diminished motivation (HP:0000745)1.94296078
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93418984
123Metabolic acidosis (HP:0001942)1.92984301
124Spontaneous abortion (HP:0005268)1.92930293
125Mitral stenosis (HP:0001718)1.92594723
126Impaired vibration sensation in the lower limbs (HP:0002166)1.90410482
127Reticulocytosis (HP:0001923)1.90329752
128Dysmetria (HP:0001310)1.89324050
129Testicular neoplasm (HP:0010788)1.88636758
130Turricephaly (HP:0000262)1.88390009
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87363904
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84836084
133Brushfield spots (HP:0001088)1.84545512
134Gingival bleeding (HP:0000225)1.84301998
135Abnormality of the gallbladder (HP:0005264)1.84262929
136Hyperinsulinemic hypoglycemia (HP:0000825)1.84126466
137Arterial tortuosity (HP:0005116)1.83329759
138J-shaped sella turcica (HP:0002680)1.83046402
139Truncal ataxia (HP:0002078)1.82508254
140Confusion (HP:0001289)1.82169187
141Insomnia (HP:0100785)1.81563350
142Spastic gait (HP:0002064)1.81297416
143Neuronal loss in central nervous system (HP:0002529)1.81261175
144Steatorrhea (HP:0002570)1.80549634
145Agitation (HP:0000713)1.80512923
146Rapidly progressive (HP:0003678)1.80161393
147Progressive cerebellar ataxia (HP:0002073)1.79706233
148Obstructive lung disease (HP:0006536)1.79334082
149Chronic obstructive pulmonary disease (HP:0006510)1.79334082
150Ankle clonus (HP:0011448)1.78624635
151Vascular tortuosity (HP:0004948)1.77604032
152Myositis (HP:0100614)1.77302158
153Epileptic encephalopathy (HP:0200134)1.76810567
154Systemic lupus erythematosus (HP:0002725)1.76473432
155Distal upper limb amyotrophy (HP:0007149)1.76308577
156Upper limb amyotrophy (HP:0009129)1.76308577
157Recurrent bacterial skin infections (HP:0005406)1.76298632
158Dementia (HP:0000726)1.75364087
159Gastrointestinal infarctions (HP:0005244)1.74144164
160Prolonged bleeding time (HP:0003010)1.73497808
161Macroorchidism (HP:0000053)1.73229030
162Increased IgE level (HP:0003212)1.73103233
163Decreased motor nerve conduction velocity (HP:0003431)1.72252720
164Hemiplegia (HP:0002301)1.71743543
165Recurrent gram-negative bacterial infections (HP:0005420)1.70928499
166Spinal canal stenosis (HP:0003416)1.70073279
167Segmental peripheral demyelination/remyelination (HP:0003481)1.69428422
168Gingivitis (HP:0000230)1.69401371
169Polygenic inheritance (HP:0010982)1.66352302
170Orchitis (HP:0100796)1.65887189
171Episodic fever (HP:0001954)1.65822327
172Nuclear cataract (HP:0100018)1.62516214
173Hyperacusis (HP:0010780)1.62460405
174Bradykinesia (HP:0002067)1.61758679
175Interstitial pulmonary disease (HP:0006530)1.61243938
176Increased CSF protein (HP:0002922)1.60238635
177Abnormality of saccadic eye movements (HP:0000570)1.60155430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.25092661
2DAPK23.01900281
3PRPF4B3.00179414
4NTRK32.99546709
5MAP3K92.82596372
6KSR22.40000770
7PRKD32.30566994
8TRIB32.29443089
9CAMKK12.25839570
10MAP2K42.24654753
11BCKDK2.20059612
12ERN11.98011749
13MAP3K41.96558831
14MARK11.92418033
15INSRR1.88816958
16MAP3K21.83515486
17MINK11.81327380
18NTRK11.80151730
19SIK11.75623717
20PAK61.74686191
21EPHB11.67184632
22MAP3K111.52629897
23NTRK21.48514930
24SMG11.47444892
25SIK21.46173822
26MAP2K31.45229431
27RIPK41.37714800
28MAP3K31.36468004
29PKN21.35242929
30RIPK11.34667584
31STK381.30460965
32TAOK11.27062364
33CDK51.25161118
34MAP2K71.23374206
35FGFR41.22767053
36PRKD21.21665462
37RET1.21521196
38PRKCH1.21476904
39TAOK31.20365002
40DAPK11.16458871
41CAMKK21.16375564
42MAP4K11.15298359
43PINK11.15150472
44MAP3K131.11118236
45PRKCG1.10939309
46HIPK21.07639454
47GRK51.06770981
48SCYL21.05762781
49TESK11.05719117
50PDPK11.05409404
51ICK1.05378769
52TYK21.03368569
53MAP3K71.02682297
54JAK11.01756542
55MAP3K11.00025709
56FGFR30.99025032
57PDK10.98071532
58ZAP700.97885374
59CAMK1G0.97296116
60CDK190.96298645
61ARAF0.93582447
62SGK2230.92971647
63SGK4940.92971647
64BLK0.91062630
65KSR10.90829242
66WNK40.90420808
67PRKCZ0.89633191
68TYRO30.87390857
69FES0.85566330
70OXSR10.84858034
71MARK20.83889827
72CSNK1G20.81801099
73JAK20.81076131
74SGK30.80980512
75STK110.80573944
76CAMK10.79720775
77UHMK10.76880891
78EEF2K0.73836724
79IRAK30.73093469
80TAOK20.72644899
81GRK60.71865305
82PTK60.71698093
83MAPK150.69442845
84TNIK0.68369217
85PDGFRA0.66942434
86IRAK20.65245734
87MAP2K20.64965727
88NEK60.64792013
89MAPK110.63437984
90WNK30.62688786
91PTK20.61216234
92CAMK2G0.61203945
93CSK0.60880012
94PRKG20.60014932
95MAP2K10.59724864
96MAP3K120.59561008
97DYRK1B0.59536355
98PTK2B0.59427840
99ALK0.58748878
100CAMK2A0.58495102
101CAMK2B0.57681898
102MAPK120.57261773
103FYN0.57164600
104PRKACG0.55965936
105PAK30.55825666
106HCK0.55800768
107TBK10.55622216
108IRAK40.55567987
109BRAF0.55532873
110CDK150.55283385
111SYK0.55012787
112LATS20.54582573
113ROCK20.54333083
114CDC42BPA0.54128633
115PHKG20.53138876
116PHKG10.53138876
117FGFR20.50050976
118CAMK40.49984108
119CDK180.49105957
120CDK140.48774739
121CAMK1D0.48462350
122ABL20.47944630
123BMX0.47815438
124PRKAA10.47562657
125LMTK20.47550112
126RAF10.47176880
127EPHA20.46870822
128BMPR20.46761372
129CDK11A0.46593099
130RPS6KA20.46341710
131SGK20.45811485
132MST1R0.45739788
133TNK20.45680158
134RPS6KA30.45640244
135SGK10.44920893
136DAPK30.44791326
137MAP2K60.44684576
138PRKD10.42481138
139WNK10.42114663
140LRRK20.40812017

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.93311106
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.50284607
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02742537
4Arginine biosynthesis_Homo sapiens_hsa002202.74116022
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.55305187
6Butanoate metabolism_Homo sapiens_hsa006502.18095216
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14689421
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97821325
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95533252
10Tryptophan metabolism_Homo sapiens_hsa003801.92318504
11Bile secretion_Homo sapiens_hsa049761.90542743
12Fatty acid degradation_Homo sapiens_hsa000711.84718680
13Complement and coagulation cascades_Homo sapiens_hsa046101.76196656
14Other glycan degradation_Homo sapiens_hsa005111.70016850
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68512787
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68003767
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.61501329
18PPAR signaling pathway_Homo sapiens_hsa033201.54253910
19Synaptic vesicle cycle_Homo sapiens_hsa047211.50557734
20Fatty acid metabolism_Homo sapiens_hsa012121.46699522
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44714349
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.42840181
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42406449
24Peroxisome_Homo sapiens_hsa041461.39028255
25Propanoate metabolism_Homo sapiens_hsa006401.38894661
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36537324
27Histidine metabolism_Homo sapiens_hsa003401.36254456
28GnRH signaling pathway_Homo sapiens_hsa049121.35358205
29VEGF signaling pathway_Homo sapiens_hsa043701.33606166
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31321511
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31073539
32beta-Alanine metabolism_Homo sapiens_hsa004101.30547036
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29771620
34GABAergic synapse_Homo sapiens_hsa047271.26263206
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26100962
36B cell receptor signaling pathway_Homo sapiens_hsa046621.25073025
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24866846
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24595680
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.20428888
40Osteoclast differentiation_Homo sapiens_hsa043801.20076837
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.20002860
42Glioma_Homo sapiens_hsa052141.18801506
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18255895
44Pyruvate metabolism_Homo sapiens_hsa006201.16599640
45ABC transporters_Homo sapiens_hsa020101.16080783
46Sulfur metabolism_Homo sapiens_hsa009201.15805190
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.15617120
48Nicotine addiction_Homo sapiens_hsa050331.14988837
49Non-small cell lung cancer_Homo sapiens_hsa052231.14271514
50Inositol phosphate metabolism_Homo sapiens_hsa005621.12437775
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12292681
52Chemical carcinogenesis_Homo sapiens_hsa052041.12263003
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10826521
54Phenylalanine metabolism_Homo sapiens_hsa003601.10156222
55Lysosome_Homo sapiens_hsa041421.07903086
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.07048809
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06607856
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05253321
59Sphingolipid signaling pathway_Homo sapiens_hsa040711.03203362
60Endocytosis_Homo sapiens_hsa041441.01225467
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00184710
62Circadian entrainment_Homo sapiens_hsa047130.99927945
63Vibrio cholerae infection_Homo sapiens_hsa051100.99407095
64Insulin secretion_Homo sapiens_hsa049110.99220392
65Olfactory transduction_Homo sapiens_hsa047400.98898771
66Glutamatergic synapse_Homo sapiens_hsa047240.98247796
67Acute myeloid leukemia_Homo sapiens_hsa052210.96185608
68Endometrial cancer_Homo sapiens_hsa052130.96085231
69Staphylococcus aureus infection_Homo sapiens_hsa051500.95989090
70Selenocompound metabolism_Homo sapiens_hsa004500.95191485
71Amphetamine addiction_Homo sapiens_hsa050310.92580890
72Long-term potentiation_Homo sapiens_hsa047200.92566907
73ErbB signaling pathway_Homo sapiens_hsa040120.91909304
74mTOR signaling pathway_Homo sapiens_hsa041500.91711080
75Renal cell carcinoma_Homo sapiens_hsa052110.91233806
76Chronic myeloid leukemia_Homo sapiens_hsa052200.89081800
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88262101
78Caffeine metabolism_Homo sapiens_hsa002320.88047221
79Starch and sucrose metabolism_Homo sapiens_hsa005000.87998352
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.86865198
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.86494238
82Morphine addiction_Homo sapiens_hsa050320.86426369
83Choline metabolism in cancer_Homo sapiens_hsa052310.86293542
84Fat digestion and absorption_Homo sapiens_hsa049750.85461412
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84952155
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84612019
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84452057
88Salivary secretion_Homo sapiens_hsa049700.84268788
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.83860063
90Retinol metabolism_Homo sapiens_hsa008300.83572638
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83572432
92Tyrosine metabolism_Homo sapiens_hsa003500.83250698
93Tuberculosis_Homo sapiens_hsa051520.82700890
94Chemokine signaling pathway_Homo sapiens_hsa040620.81478153
95Biosynthesis of amino acids_Homo sapiens_hsa012300.80621428
96T cell receptor signaling pathway_Homo sapiens_hsa046600.80223297
97Platelet activation_Homo sapiens_hsa046110.78895108
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78634817
99Vitamin B6 metabolism_Homo sapiens_hsa007500.78497358
100Leishmaniasis_Homo sapiens_hsa051400.78240213
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.76270860
102Prolactin signaling pathway_Homo sapiens_hsa049170.75960378
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75243896
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75170518
105Phagosome_Homo sapiens_hsa041450.74694087
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74541944
107Glycerolipid metabolism_Homo sapiens_hsa005610.74484763
108Insulin signaling pathway_Homo sapiens_hsa049100.73836311
109Rap1 signaling pathway_Homo sapiens_hsa040150.73340188
110Dorso-ventral axis formation_Homo sapiens_hsa043200.73194692
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73015283
112Carbon metabolism_Homo sapiens_hsa012000.72713991
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72706550
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72695382
115Fatty acid elongation_Homo sapiens_hsa000620.72502707
116cAMP signaling pathway_Homo sapiens_hsa040240.72048209
117Gastric acid secretion_Homo sapiens_hsa049710.71877538
118Cocaine addiction_Homo sapiens_hsa050300.71768128
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71468448
120Dopaminergic synapse_Homo sapiens_hsa047280.70644897
121MAPK signaling pathway_Homo sapiens_hsa040100.69834825
122Notch signaling pathway_Homo sapiens_hsa043300.68350996
123Type II diabetes mellitus_Homo sapiens_hsa049300.66642207
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65667051
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64988991
126Pancreatic cancer_Homo sapiens_hsa052120.64843861
127Amoebiasis_Homo sapiens_hsa051460.64774407
128Sulfur relay system_Homo sapiens_hsa041220.64321950
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63695089
130Melanogenesis_Homo sapiens_hsa049160.63529526
131Gap junction_Homo sapiens_hsa045400.62321986
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62172677
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61859090
134Prion diseases_Homo sapiens_hsa050200.61772342
135Fatty acid biosynthesis_Homo sapiens_hsa000610.61217585
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.59878040
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59056165
138Cholinergic synapse_Homo sapiens_hsa047250.58411417
139Calcium signaling pathway_Homo sapiens_hsa040200.58340616
140Toxoplasmosis_Homo sapiens_hsa051450.56815291
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.56589701
142Hepatitis C_Homo sapiens_hsa051600.56254330
143Renin secretion_Homo sapiens_hsa049240.56169004
144Ras signaling pathway_Homo sapiens_hsa040140.55165710
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54279649
146Collecting duct acid secretion_Homo sapiens_hsa049660.53858114
147Thyroid hormone synthesis_Homo sapiens_hsa049180.53317514
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51145609
149Taste transduction_Homo sapiens_hsa047420.50390872
150Glucagon signaling pathway_Homo sapiens_hsa049220.50105972
151Steroid biosynthesis_Homo sapiens_hsa001000.48543799
152Folate biosynthesis_Homo sapiens_hsa007900.48330991
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46559327
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.45882510
155Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43952923
156Arginine and proline metabolism_Homo sapiens_hsa003300.42512388
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.41700926
158Lysine degradation_Homo sapiens_hsa003100.38643631
159Vitamin digestion and absorption_Homo sapiens_hsa049770.38453034
160Pancreatic secretion_Homo sapiens_hsa049720.37531311
161Insulin resistance_Homo sapiens_hsa049310.37215780
162Estrogen signaling pathway_Homo sapiens_hsa049150.37211937
163Long-term depression_Homo sapiens_hsa047300.35050213
164Oxytocin signaling pathway_Homo sapiens_hsa049210.34412831

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