FAM132A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme biosynthetic process (GO:0006783)6.90567517
2DNA deamination (GO:0045006)6.82287246
3angiotensin maturation (GO:0002003)6.81140310
4regulation of guanylate cyclase activity (GO:0031282)5.85620608
5ribosomal small subunit assembly (GO:0000028)5.78771274
6protoporphyrinogen IX biosynthetic process (GO:0006782)5.76712308
7protoporphyrinogen IX metabolic process (GO:0046501)5.72766225
8heme metabolic process (GO:0042168)5.68889174
9NADH metabolic process (GO:0006734)5.68797878
10intestinal absorption (GO:0050892)5.62072003
11plasma lipoprotein particle assembly (GO:0034377)5.61945991
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.54363619
13viral transcription (GO:0019083)5.47612770
14porphyrin-containing compound biosynthetic process (GO:0006779)5.40947348
15very-low-density lipoprotein particle assembly (GO:0034379)5.38918803
16diacylglycerol metabolic process (GO:0046339)5.35646817
17translational termination (GO:0006415)5.33608277
18regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.33222336
19protein-lipid complex assembly (GO:0065005)5.28953712
20phospholipid efflux (GO:0033700)5.03938775
21lipoprotein transport (GO:0042953)4.99809368
22telomere maintenance via semi-conservative replication (GO:0032201)4.97239313
23regulation of triglyceride catabolic process (GO:0010896)4.96727608
24tetrapyrrole biosynthetic process (GO:0033014)4.84512810
25translational elongation (GO:0006414)4.81957007
26protein autoprocessing (GO:0016540)4.80735074
27proteasome assembly (GO:0043248)4.78970034
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.74667981
29DNA strand elongation involved in DNA replication (GO:0006271)4.74176499
30DNA replication initiation (GO:0006270)4.73829096
31cotranslational protein targeting to membrane (GO:0006613)4.63048409
32protein targeting to ER (GO:0045047)4.61974994
33transepithelial transport (GO:0070633)4.56996857
34one-carbon compound transport (GO:0019755)4.53390359
352-deoxyribonucleotide biosynthetic process (GO:0009265)4.49489775
36deoxyribose phosphate biosynthetic process (GO:0046385)4.49489775
37DNA strand elongation (GO:0022616)4.48498967
38erythrocyte maturation (GO:0043249)4.45841388
39porphyrin-containing compound metabolic process (GO:0006778)4.45639687
40regulation of cholesterol esterification (GO:0010872)4.45069584
41protein localization to endoplasmic reticulum (GO:0070972)4.43725812
42high-density lipoprotein particle remodeling (GO:0034375)4.41765850
43ribosomal small subunit biogenesis (GO:0042274)4.41528650
44fat-soluble vitamin biosynthetic process (GO:0042362)4.40894958
45establishment of protein localization to endoplasmic reticulum (GO:0072599)4.39315321
46fructose metabolic process (GO:0006000)4.28146058
47GDP-mannose metabolic process (GO:0019673)4.26532034
48positive regulation of guanylate cyclase activity (GO:0031284)4.22508525
49maturation of SSU-rRNA (GO:0030490)4.21918146
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21883958
51translational initiation (GO:0006413)4.21176125
52DNA replication checkpoint (GO:0000076)4.16888975
53hemidesmosome assembly (GO:0031581)4.16283475
54pseudouridine synthesis (GO:0001522)4.14704857
55telomere maintenance via recombination (GO:0000722)4.12299318
56deoxyribonucleotide biosynthetic process (GO:0009263)4.12210330
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.12151446
58viral life cycle (GO:0019058)4.11051153
59folic acid metabolic process (GO:0046655)4.09531776
60cellular protein complex disassembly (GO:0043624)4.08691139
61folic acid-containing compound biosynthetic process (GO:0009396)4.01476576
62CENP-A containing nucleosome assembly (GO:0034080)3.99891484
63positive regulation of lipoprotein lipase activity (GO:0051006)3.97992035
64positive regulation of triglyceride lipase activity (GO:0061365)3.97992035
65homocysteine metabolic process (GO:0050667)3.97502949
66oxidative phosphorylation (GO:0006119)3.95698469
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.91897630
68purine ribonucleotide transport (GO:0015868)3.83390218
69chromatin remodeling at centromere (GO:0031055)3.81857065
70translation (GO:0006412)3.79134222
71epoxygenase P450 pathway (GO:0019373)3.77997994
72regulation of autophagic vacuole assembly (GO:2000785)3.75425461
73adenine nucleotide transport (GO:0051503)3.72507535
74iron-sulfur cluster assembly (GO:0016226)3.69266068
75metallo-sulfur cluster assembly (GO:0031163)3.69266068
76ribosomal large subunit biogenesis (GO:0042273)3.68995116
77formation of translation preinitiation complex (GO:0001731)3.68232585
78ATP synthesis coupled proton transport (GO:0015986)3.64475761
79energy coupled proton transport, down electrochemical gradient (GO:0015985)3.64475761
80receptor guanylyl cyclase signaling pathway (GO:0007168)3.63596517
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61429632
82mitotic recombination (GO:0006312)3.60211462
83lysine metabolic process (GO:0006553)3.56840044
84lysine catabolic process (GO:0006554)3.56840044
85pyrimidine nucleotide catabolic process (GO:0006244)3.56426335
86ribonucleoprotein complex biogenesis (GO:0022613)3.53081009
87regulation of cellular extravasation (GO:0002691)3.52740038
88protein complex disassembly (GO:0043241)3.49222202
89reverse cholesterol transport (GO:0043691)3.46916083
90pigment biosynthetic process (GO:0046148)3.46684112
91glycosphingolipid catabolic process (GO:0046479)3.46116889
92adhesion of symbiont to host cell (GO:0044650)3.45972536
93virion attachment to host cell (GO:0019062)3.45972536
94pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.45229303
95pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.45041697
96telomere maintenance via telomere lengthening (GO:0010833)3.44717196
97glucose 6-phosphate metabolic process (GO:0051156)3.43307126
98protein targeting to mitochondrion (GO:0006626)3.42958088
99DNA replication-independent nucleosome organization (GO:0034724)3.42003795
100DNA replication-independent nucleosome assembly (GO:0006336)3.42003795
101regulation of systemic arterial blood pressure by hormone (GO:0001990)3.40844202
102regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.40844202
103endocrine process (GO:0050886)3.40844202
104spliceosomal snRNP assembly (GO:0000387)3.39719976
105sulfate transmembrane transport (GO:1902358)3.39690159
106lipoprotein metabolic process (GO:0042157)3.39568348
107protein-lipid complex remodeling (GO:0034368)3.38524436
108macromolecular complex remodeling (GO:0034367)3.38524436
109plasma lipoprotein particle remodeling (GO:0034369)3.38524436
110drug metabolic process (GO:0017144)3.35597133
111rRNA modification (GO:0000154)3.33226793
112glycolipid catabolic process (GO:0019377)3.32997427
113urea cycle (GO:0000050)3.31358299
114macromolecular complex disassembly (GO:0032984)3.30986362
115glutamine family amino acid biosynthetic process (GO:0009084)3.30781827
116regulation of mitochondrial translation (GO:0070129)3.30726504
117adhesion of symbiont to host (GO:0044406)3.29825750
118positive regulation of osteoblast proliferation (GO:0033690)3.29340475
119oligosaccharide catabolic process (GO:0009313)3.29130008
120plasma lipoprotein particle organization (GO:0071827)3.28528286
121exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27236459
122regulation of systemic arterial blood pressure (GO:0003073)3.25719174
123protein-lipid complex subunit organization (GO:0071825)3.24679025
124nucleotide-excision repair, DNA gap filling (GO:0006297)3.23203339
125erythrocyte development (GO:0048821)3.22382398
126rRNA processing (GO:0006364)3.22153351
127establishment of protein localization to mitochondrion (GO:0072655)3.21494999
128glutathione biosynthetic process (GO:0006750)3.21367676
129nucleoside diphosphate biosynthetic process (GO:0009133)3.21329999
130gas transport (GO:0015669)3.21235805
131nuclear-transcribed mRNA catabolic process (GO:0000956)3.20867755
132ribosome biogenesis (GO:0042254)3.20634829
133purine nucleotide transport (GO:0015865)3.20555045
134negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19670335
135pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.18797953
136urea metabolic process (GO:0019627)3.18736787
137pteridine-containing compound biosynthetic process (GO:0042559)3.18117938
138DNA unwinding involved in DNA replication (GO:0006268)3.17402313
139desmosome organization (GO:0002934)3.16657502
140deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.15333652
141cholesterol efflux (GO:0033344)3.15017941
142transcription elongation from RNA polymerase III promoter (GO:0006385)3.13601650
143termination of RNA polymerase III transcription (GO:0006386)3.13601650
144regulation of vitamin metabolic process (GO:0030656)3.13578732
145tetrapyrrole metabolic process (GO:0033013)3.11542307
146pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.10837939
147rRNA metabolic process (GO:0016072)3.10389184
148positive regulation of lipid catabolic process (GO:0050996)3.10136835
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10061532
150protein targeting to membrane (GO:0006612)3.09886373
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08199683
152cellular component biogenesis (GO:0044085)3.07827555
153protein localization to mitochondrion (GO:0070585)3.07340022
154mannose metabolic process (GO:0006013)3.07210275
155nonribosomal peptide biosynthetic process (GO:0019184)3.06067100
156positive regulation of Cdc42 GTPase activity (GO:0043089)3.04702271
157tRNA methylation (GO:0030488)3.03609879
158mRNA catabolic process (GO:0006402)3.03425103
159regulation of cGMP biosynthetic process (GO:0030826)3.03414702
160regulation of cholesterol homeostasis (GO:2000188)3.01917434
161sphingosine metabolic process (GO:0006670)3.01541656
162regulation of protein heterodimerization activity (GO:0043497)3.01298849
163peptide catabolic process (GO:0043171)3.00220243
164histone mRNA metabolic process (GO:0008334)2.98576186
165pigment metabolic process (GO:0042440)2.98462674
166negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97113190
167NIK/NF-kappaB signaling (GO:0038061)2.96585689
168vitamin A metabolic process (GO:0006776)2.96506931
169spliceosomal complex assembly (GO:0000245)2.96443827
170regulation of vacuole organization (GO:0044088)2.95863869
171nitrogen cycle metabolic process (GO:0071941)2.95308156
172bile acid and bile salt transport (GO:0015721)2.94539151
173proline biosynthetic process (GO:0006561)2.94437581
174antimicrobial humoral response (GO:0019730)2.94275309
175positive regulation of triglyceride metabolic process (GO:0090208)2.93336094
176protein retention in ER lumen (GO:0006621)2.91916705
177maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.91632712
178renal system process involved in regulation of blood volume (GO:0001977)2.88381711
179antibacterial humoral response (GO:0019731)2.85855308
180regulation of cholesterol metabolic process (GO:0090181)2.83346384
181L-ascorbic acid metabolic process (GO:0019852)2.82739012
182hormone catabolic process (GO:0042447)2.82654287
183triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81266352
184positive regulation of pseudopodium assembly (GO:0031274)2.80732048
185negative regulation of fatty acid biosynthetic process (GO:0045717)2.79369149
186negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.78569211
187fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.75431446
188leukotriene metabolic process (GO:0006691)2.74250456
189negative regulation of lipase activity (GO:0060192)2.72132950
190auditory receptor cell differentiation (GO:0042491)2.71889407
191polyol transport (GO:0015791)2.68178236
192sulfate transport (GO:0008272)2.67633674
193granulocyte differentiation (GO:0030851)2.66932634
194cellular response to zinc ion (GO:0071294)2.66851650
195vitamin transport (GO:0051180)2.65226037
196cholesterol homeostasis (GO:0042632)2.63749482
197arachidonic acid metabolic process (GO:0019369)2.63624088
198regulation of bile acid biosynthetic process (GO:0070857)2.62334715
199nucleoside transport (GO:0015858)2.62327809
200positive regulation of fatty acid biosynthetic process (GO:0045723)2.59902605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.10778351
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.24783719
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.54201611
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.39511254
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42204939
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33489006
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.25249495
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.11121414
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07206580
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.04125458
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86833443
12LXR_22292898_ChIP-Seq_THP-1_Human2.83082573
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71910392
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64866424
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62946522
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.59166359
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58847830
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57565736
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41782250
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41419471
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.39925193
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39867254
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38936383
24VDR_23849224_ChIP-Seq_CD4+_Human2.31944353
25XRN2_22483619_ChIP-Seq_HELA_Human2.28771541
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27850920
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25025339
28DCP1A_22483619_ChIP-Seq_HELA_Human2.23259978
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.15542266
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15247568
31RACK7_27058665_Chip-Seq_MCF-7_Human2.13334533
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11897915
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11179704
34GABP_19822575_ChIP-Seq_HepG2_Human2.10668962
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.10313287
36ELK3_25401928_ChIP-Seq_HUVEC_Human2.09859789
37P68_20966046_ChIP-Seq_HELA_Human2.02155912
38CDX2_20551321_ChIP-Seq_CACO-2_Human2.01827185
39STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01236915
40AR_21909140_ChIP-Seq_LNCAP_Human2.01114495
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99974871
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95243920
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94024930
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.92041785
45FOXP3_21729870_ChIP-Seq_TREG_Human1.91240966
46TTF2_22483619_ChIP-Seq_HELA_Human1.86879562
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83030321
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.79155354
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78826082
50BCOR_27268052_Chip-Seq_Bcells_Human1.78432934
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76841158
52* SA1_27219007_Chip-Seq_ERYTHROID_Human1.75803067
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75387329
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74042866
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.73941009
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72063551
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70216142
58BCL6_27268052_Chip-Seq_Bcells_Human1.68598919
59* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66907891
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66349219
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.66116133
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65758776
63* CTCF_27219007_Chip-Seq_Bcells_Human1.65479527
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.64091156
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63597872
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63205859
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.61644518
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61203435
69GATA1_22025678_ChIP-Seq_K562_Human1.59762111
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.59546053
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.58525151
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58123832
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57969634
74* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54275006
75KDM2B_26808549_Chip-Seq_DND41_Human1.54081717
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53914524
77* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51991884
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51287376
79* E2F1_20622854_ChIP-Seq_HELA_Human1.47711677
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.47624459
81* SA1_27219007_Chip-Seq_Bcells_Human1.47314076
82* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47201859
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46847475
84MYC_22102868_ChIP-Seq_BL_Human1.46140717
85GATA6_25053715_ChIP-Seq_YYC3_Human1.45697523
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44977004
87PHF8_20622854_ChIP-Seq_HELA_Human1.44890642
88ELK1_19687146_ChIP-ChIP_HELA_Human1.44603514
89SMC4_20622854_ChIP-Seq_HELA_Human1.44521212
90CREB1_26743006_Chip-Seq_LNCaP_Human1.43570255
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.43097377
92ZNF263_19887448_ChIP-Seq_K562_Human1.42980886
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41391536
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41261292
95ATF3_27146783_Chip-Seq_COLON_Human1.40621106
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39747416
97CIITA_25753668_ChIP-Seq_RAJI_Human1.38586406
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37180860
99TCF7_22412390_ChIP-Seq_EML_Mouse1.37051950
100VDR_21846776_ChIP-Seq_THP-1_Human1.35209535
101NCOR1_26117541_ChIP-Seq_K562_Human1.35131260
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.34707397
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34594184
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33663918
105SCL_19346495_ChIP-Seq_HPC-7_Human1.33489878
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33338315
107RARA_24833708_ChIP-Seq_LIVER_Mouse1.33143968
108P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32503740
109TP53_22127205_ChIP-Seq_IMR90_Human1.32053579
110DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31490690
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31204424
112KDM5A_27292631_Chip-Seq_BREAST_Human1.30234429
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29741626
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29523207
115MAF_26560356_Chip-Seq_TH2_Human1.28625673
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28310696
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28022259
118EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27690124
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25901150
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24028376
121GATA1_19941827_ChIP-Seq_MEL_Mouse1.23754769
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22305337
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22278975
124TP63_22573176_ChIP-Seq_HFKS_Human1.22038250
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21381666
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20937885
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20707490
128SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19053228
129KDM2B_26808549_Chip-Seq_K562_Human1.18942809
130NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18886824
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18243128
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16987174
133ESR2_21235772_ChIP-Seq_MCF-7_Human1.16814013
134* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.16427123
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16054162
136YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15855012
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15041368
138CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14157186
139PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13421582
140STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11321461
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10904155
142UTX_26944678_Chip-Seq_JUKART_Human1.10902732
143CTCF_20526341_ChIP-Seq_ESCs_Human1.10390863
144CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09493030
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08636526
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08375798
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08189000
148CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07871465
149CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07329530
150ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05883939
151MYC_18940864_ChIP-ChIP_HL60_Human1.05824145
152DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04717080
153IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04241736
154VDR_24763502_ChIP-Seq_THP-1_Human1.04213565
155ETS1_21867929_ChIP-Seq_TH2_Mouse1.04109709
156P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03883340
157GATA1_19941826_ChIP-Seq_K562_Human1.03822529
158KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03542929
159MAF_26560356_Chip-Seq_TH1_Human1.02629620
160TFEB_21752829_ChIP-Seq_HELA_Human1.02332631
161BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01365655
162CLOCK_20551151_ChIP-Seq_293T_Human1.01105983
163FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00955506
164RUNX1_27514584_Chip-Seq_MCF-7_Human1.00556869
165CTCF_21964334_Chip-Seq_Bcells_Human0.99900082
166TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99815297
167E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99369313
168RARB_24833708_ChIP-Seq_LIVER_Mouse0.99134830
169ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98965227
170KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98710715
171MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95859951
172ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95575467
173SPI1_23547873_ChIP-Seq_NB4_Human0.94300797
174HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93380445
175TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93164772
176HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93015223
177CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89141757
178SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88513687
179FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88157756
180EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87737379
181MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86975846
182CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86743757
183ELK1_22589737_ChIP-Seq_MCF10A_Human0.84973999
184YY1_22570637_ChIP-Seq_MALME-3M_Human0.83385998
185TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83222335
186CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81733309
187RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81511758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo7.08344573
2MP0004147_increased_porphyrin_level6.97019858
3MP0006054_spinal_hemorrhage6.73489598
4MP0009840_abnormal_foam_cell5.85389255
5MP0003693_abnormal_embryo_hatching3.66545487
6MP0003806_abnormal_nucleotide_metabolis3.63828121
7MP0004957_abnormal_blastocyst_morpholog3.45856732
8MP0001545_abnormal_hematopoietic_system3.36012010
9MP0005397_hematopoietic_system_phenotyp3.36012010
10MP0010094_abnormal_chromosome_stability3.07204624
11MP0003111_abnormal_nucleus_morphology2.97646879
12MP0002396_abnormal_hematopoietic_system2.89541436
13MP0001666_abnormal_nutrient_absorption2.78180452
14MP0010234_abnormal_vibrissa_follicle2.69400829
15MP0004019_abnormal_vitamin_homeostasis2.69239129
16MP0008057_abnormal_DNA_replication2.67032179
17MP0004215_abnormal_myocardial_fiber2.61783614
18MP0005409_darkened_coat_color2.61537687
19MP0006036_abnormal_mitochondrial_physio2.57692469
20MP0000678_abnormal_parathyroid_gland2.49420371
21MP0003077_abnormal_cell_cycle2.46029616
22MP0004264_abnormal_extraembryonic_tissu2.38799741
23MP0008058_abnormal_DNA_repair2.37742651
24MP0003186_abnormal_redox_activity2.37482487
25MP0003183_abnormal_peptide_metabolism2.36284863
26MP0000490_abnormal_crypts_of2.31230903
27MP0002132_abnormal_respiratory_system2.24772872
28MP0005365_abnormal_bile_salt2.11558303
29MP0005085_abnormal_gallbladder_physiolo2.11454947
30MP0010155_abnormal_intestine_physiology2.10905738
31MP0005636_abnormal_mineral_homeostasis1.87695755
32MP0009333_abnormal_splenocyte_physiolog1.83772169
33MP0001849_ear_inflammation1.81875058
34MP0005451_abnormal_body_composition1.80451665
35MP0006035_abnormal_mitochondrial_morpho1.72425519
36MP0003436_decreased_susceptibility_to1.71409394
37MP0008007_abnormal_cellular_replicative1.71290409
38MP0008775_abnormal_heart_ventricle1.65498227
39MP0002796_impaired_skin_barrier1.61624085
40MP0009379_abnormal_foot_pigmentation1.60310957
41MP0003453_abnormal_keratinocyte_physiol1.59044300
42MP0005332_abnormal_amino_acid1.58998606
43MP0003705_abnormal_hypodermis_morpholog1.58365232
44MP0004858_abnormal_nervous_system1.57108751
45MP0002249_abnormal_larynx_morphology1.54744884
46MP0005058_abnormal_lysosome_morphology1.49373038
47MP0008932_abnormal_embryonic_tissue1.49183095
48MP0004043_abnormal_pH_regulation1.46213250
49MP0010329_abnormal_lipoprotein_level1.45948899
50MP0003724_increased_susceptibility_to1.45758733
51MP0001664_abnormal_digestion1.41812014
52MP0002098_abnormal_vibrissa_morphology1.39144836
53MP0001188_hyperpigmentation1.36966376
54MP0000538_abnormal_urinary_bladder1.34350179
55MP0000579_abnormal_nail_morphology1.31718834
56MP0005076_abnormal_cell_differentiation1.28896267
57MP0002398_abnormal_bone_marrow1.23860157
58MP0001853_heart_inflammation1.23771748
59MP0008260_abnormal_autophagy1.23453498
60MP0000313_abnormal_cell_death1.18970667
61MP0005257_abnormal_intraocular_pressure1.18110203
62MP0003878_abnormal_ear_physiology1.17786111
63MP0005377_hearing/vestibular/ear_phenot1.17786111
64MP0002722_abnormal_immune_system1.17051089
65MP0000358_abnormal_cell_content/1.16636318
66MP0002822_catalepsy1.13124183
67MP0008789_abnormal_olfactory_epithelium1.12673209
68MP0005174_abnormal_tail_pigmentation1.12445365
69MP0000689_abnormal_spleen_morphology1.11134740
70MP0005666_abnormal_adipose_tissue1.08716705
71MP0000350_abnormal_cell_proliferation1.08610725
72MP0001216_abnormal_epidermal_layer1.06725764
73MP0003786_premature_aging1.05586377
74MP0002136_abnormal_kidney_physiology1.05430746
75MP0001764_abnormal_homeostasis1.04172113
76MP0002019_abnormal_tumor_incidence1.04049110
77MP0003303_peritoneal_inflammation1.03506212
78MP0001730_embryonic_growth_arrest1.01760912
79MP0003763_abnormal_thymus_physiology1.01485475
80MP0004947_skin_inflammation1.00104299
81MP0001661_extended_life_span0.99431009
82MP0002429_abnormal_blood_cell0.98233162
83MP0004808_abnormal_hematopoietic_stem0.95373000
84MP0008872_abnormal_physiological_respon0.92958386
85MP0003191_abnormal_cellular_cholesterol0.92581521
86MP0001765_abnormal_ion_homeostasis0.92431177
87MP0000467_abnormal_esophagus_morphology0.92323660
88MP0002118_abnormal_lipid_homeostasis0.91843873
89MP0001243_abnormal_dermal_layer0.91720692
90MP0005381_digestive/alimentary_phenotyp0.91041455
91MP0005375_adipose_tissue_phenotype0.90948849
92MP0002876_abnormal_thyroid_physiology0.90286541
93MP0002080_prenatal_lethality0.89573082
94MP0002102_abnormal_ear_morphology0.89017954
95MP0003718_maternal_effect0.88611845
96MP0000703_abnormal_thymus_morphology0.87503907
97MP0000003_abnormal_adipose_tissue0.86224826
98MP0000377_abnormal_hair_follicle0.83647398
99MP0005394_taste/olfaction_phenotype0.82842600
100MP0005499_abnormal_olfactory_system0.82842600
101MP0000566_synostosis0.82577095
102MP0005075_abnormal_melanosome_morpholog0.81985078
103MP0001663_abnormal_digestive_system0.81829749
104MP0004270_analgesia0.81368087
105MP0000749_muscle_degeneration0.81329932
106MP0005266_abnormal_metabolism0.81185416
107MP0009764_decreased_sensitivity_to0.81064251
108MP0002060_abnormal_skin_morphology0.78717698
109MP0008469_abnormal_protein_level0.77835648
110MP0005275_abnormal_skin_tensile0.77756274
111MP0005584_abnormal_enzyme/coenzyme_acti0.76371496
112MP0004782_abnormal_surfactant_physiolog0.75688403
113MP0005319_abnormal_enzyme/_coenzyme0.75640749
114MP0005023_abnormal_wound_healing0.75328467
115MP0000681_abnormal_thyroid_gland0.73602037
116MP0002254_reproductive_system_inflammat0.73452692
117MP0005166_decreased_susceptibility_to0.72027232
118MP0002095_abnormal_skin_pigmentation0.71523308
119MP0003567_abnormal_fetal_cardiomyocyte0.71275657
120MP0008438_abnormal_cutaneous_collagen0.70868452
121MP0009931_abnormal_skin_appearance0.69868024
122MP0010771_integument_phenotype0.69794815
123MP0004185_abnormal_adipocyte_glucose0.69514274
124MP0000013_abnormal_adipose_tissue0.69146836
125MP0004272_abnormal_basement_membrane0.68125281
126MP0001697_abnormal_embryo_size0.67779190
127MP0000685_abnormal_immune_system0.67595975
128MP0001756_abnormal_urination0.67129753
129MP0001845_abnormal_inflammatory_respons0.66183984
130MP0005501_abnormal_skin_physiology0.65578870
131MP0000049_abnormal_middle_ear0.65488844
132MP0002139_abnormal_hepatobiliary_system0.65055127
133MP0009643_abnormal_urine_homeostasis0.65026278
134MP0005670_abnormal_white_adipose0.64800999
135MP0001529_abnormal_vocalization0.64305989
136MP0000716_abnormal_immune_system0.63713072
137MP0000537_abnormal_urethra_morphology0.63443270
138MP0005330_cardiomyopathy0.62594465
139MP0009115_abnormal_fat_cell0.62325868
140MP0001915_intracranial_hemorrhage0.60971578
141MP0003329_amyloid_beta_deposits0.60751477
142MP0002971_abnormal_brown_adipose0.59714783
143MP0002135_abnormal_kidney_morphology0.58750385
144MP0010352_gastrointestinal_tract_polyps0.58386242
145MP0008875_abnormal_xenobiotic_pharmacok0.57735202
146MP0001533_abnormal_skeleton_physiology0.56644291
147MP0005376_homeostasis/metabolism_phenot0.55647471
148MP0000598_abnormal_liver_morphology0.54576823
149MP0000604_amyloidosis0.54295813
150MP0000609_abnormal_liver_physiology0.52578718
151MP0002970_abnormal_white_adipose0.51775981
152MP0003172_abnormal_lysosome_physiology0.51381063
153MP0000477_abnormal_intestine_morphology0.50523169
154MP0003221_abnormal_cardiomyocyte_apopto0.48925273
155MP0002166_altered_tumor_susceptibility0.48282785
156MP0005360_urolithiasis0.46296144
157MP0009785_altered_susceptibility_to0.46118676
158MP0010307_abnormal_tumor_latency0.46027355
159MP0003866_abnormal_defecation0.45420929
160MP0001873_stomach_inflammation0.43794678
161MP0005671_abnormal_response_to0.43232168
162MP0003123_paternal_imprinting0.42689614
163MP0000858_altered_metastatic_potential0.42535988
164MP0005384_cellular_phenotype0.42438158
165MP0002089_abnormal_postnatal_growth/wei0.41499587
166MP0000747_muscle_weakness0.41116964
167MP0002269_muscular_atrophy0.40690813
168MP0002405_respiratory_system_inflammati0.40615130
169MP0005025_abnormal_response_to0.40384975
170MP0000465_gastrointestinal_hemorrhage0.39815881
171MP0001145_abnormal_male_reproductive0.39613673
172MP0008873_increased_physiological_sensi0.39459263
173MP0005464_abnormal_platelet_physiology0.39368684

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)9.09305040
2Abnormality of cells of the erythroid lineage (HP:0012130)8.82075295
3Malnutrition (HP:0004395)6.41022364
4Abnormality of glutamine family amino acid metabolism (HP:0010902)6.35725509
5Birth length less than 3rd percentile (HP:0003561)4.96957365
6Pallor (HP:0000980)4.53166111
7Hypobetalipoproteinemia (HP:0003563)4.42156694
8Reticulocytopenia (HP:0001896)4.35401323
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.18386426
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.18386426
11Poikilocytosis (HP:0004447)4.16200580
12Hydroxyprolinuria (HP:0003080)4.11906812
13Abnormality of proline metabolism (HP:0010907)4.11906812
14Abnormality of reticulocytes (HP:0004312)4.02984546
15Increased serum ferritin (HP:0003281)4.00444253
16Aplastic anemia (HP:0001915)3.84931052
17Reticulocytosis (HP:0001923)3.84750109
18Hepatocellular necrosis (HP:0001404)3.80426826
19Mitochondrial inheritance (HP:0001427)3.66860515
20Macrocytic anemia (HP:0001972)3.54945284
21Abnormal mitochondria in muscle tissue (HP:0008316)3.53482923
22Acute necrotizing encephalopathy (HP:0006965)3.50398591
23Increased CSF lactate (HP:0002490)3.47773979
24Hepatic necrosis (HP:0002605)3.41879759
25Abnormality of iron homeostasis (HP:0011031)3.37580182
26Widely patent fontanelles and sutures (HP:0004492)3.36007268
27Thin bony cortex (HP:0002753)3.35641006
28Oral leukoplakia (HP:0002745)3.32781951
29Acanthocytosis (HP:0001927)3.30757340
30Abnormality of transition element cation homeostasis (HP:0011030)3.29797692
31Increased serum lactate (HP:0002151)3.19821975
32Petechiae (HP:0000967)3.16649034
33Abnormality of alanine metabolism (HP:0010916)3.14320279
34Hyperalaninemia (HP:0003348)3.14320279
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14320279
36Systemic lupus erythematosus (HP:0002725)3.12856924
37Acute encephalopathy (HP:0006846)3.10046061
38Increased intramyocellular lipid droplets (HP:0012240)3.01936373
39Confusion (HP:0001289)2.98159645
40Atrophic scars (HP:0001075)2.96413157
41Hyperbilirubinemia (HP:0002904)2.95916105
42Hemorrhage of the eye (HP:0011885)2.95242524
43Increased muscle lipid content (HP:0009058)2.94671610
44Microretrognathia (HP:0000308)2.94555320
45Lactic acidosis (HP:0003128)2.89976693
46Increased hepatocellular lipid droplets (HP:0006565)2.87626029
47Abnormality of the vitamin B12 metabolism (HP:0004341)2.87516507
48Lipid accumulation in hepatocytes (HP:0006561)2.86551278
49Diaphragmatic weakness (HP:0009113)2.84561931
50Flat acetabular roof (HP:0003180)2.81643991
513-Methylglutaconic aciduria (HP:0003535)2.77367162
52Prolonged neonatal jaundice (HP:0006579)2.74292107
53Wide cranial sutures (HP:0010537)2.73153318
54Nausea (HP:0002018)2.70674318
55Milia (HP:0001056)2.69922655
56Progressive macrocephaly (HP:0004481)2.67902489
57Alopecia of scalp (HP:0002293)2.65470724
58Chronic diarrhea (HP:0002028)2.63249643
59Pili torti (HP:0003777)2.60724339
60Prolonged bleeding time (HP:0003010)2.58659245
61Respiratory failure (HP:0002878)2.53580010
62Abdominal distention (HP:0003270)2.53172484
63Breast hypoplasia (HP:0003187)2.52969906
64Abnormality of vitamin B metabolism (HP:0004340)2.52530603
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51494501
66Fragile nails (HP:0001808)2.51128109
67Exertional dyspnea (HP:0002875)2.49157545
68Hyperparathyroidism (HP:0000843)2.47837128
69Abnormal blistering of the skin (HP:0008066)2.45259332
70Eczematoid dermatitis (HP:0000976)2.42689133
71Abnormality of pyrimidine metabolism (HP:0004353)2.41026423
72Respiratory difficulties (HP:0002880)2.39858346
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39850306
74Ileus (HP:0002595)2.39668474
75Epidermoid cyst (HP:0200040)2.35694711
76Delayed epiphyseal ossification (HP:0002663)2.35557051
77Short middle phalanx of the 5th finger (HP:0004220)2.33660533
78Abnormality of the costochondral junction (HP:0000919)2.33473038
79Type I transferrin isoform profile (HP:0003642)2.33443685
80Pancytopenia (HP:0001876)2.32198898
81Rectal prolapse (HP:0002035)2.30935807
82Myopathic facies (HP:0002058)2.28834985
83Severe visual impairment (HP:0001141)2.28518673
84Abnormal hair laboratory examination (HP:0003328)2.27194353
85Hypolipoproteinemia (HP:0010981)2.26360895
86Hypoplasia of the pons (HP:0012110)2.25181693
87Rough bone trabeculation (HP:0100670)2.23980347
88Fat malabsorption (HP:0002630)2.23810446
89Cerebellar dysplasia (HP:0007033)2.21199119
90Exercise intolerance (HP:0003546)2.21083802
91Xanthomatosis (HP:0000991)2.19931899
92Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19563311
93Polycythemia (HP:0001901)2.18139313
94Plantar hyperkeratosis (HP:0007556)2.18134431
95Cutaneous photosensitivity (HP:0000992)2.16142170
96Abnormality of the pons (HP:0007361)2.16135947
97Brushfield spots (HP:0001088)2.15801292
98Nephrolithiasis (HP:0000787)2.14446493
99Villous atrophy (HP:0011473)2.13018090
100Abnormality of small intestinal villus morphology (HP:0011472)2.13018090
101Proximal tubulopathy (HP:0000114)2.09720128
102Cerebral hypomyelination (HP:0006808)2.08304169
103Poor head control (HP:0002421)2.06148972
104Flattened epiphyses (HP:0003071)2.06017757
105Microvesicular hepatic steatosis (HP:0001414)2.05983946
106Pustule (HP:0200039)2.04800843
107Abnormality of nail color (HP:0100643)2.03025605
108Selective tooth agenesis (HP:0001592)2.01666735
109Abnormality of the heme biosynthetic pathway (HP:0010472)12.0585549
110Onycholysis (HP:0001806)1.97881389
111Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97504400
112CNS demyelination (HP:0007305)1.97064113
113Abnormality of the acetabulum (HP:0003170)1.95978701
114Vacuolated lymphocytes (HP:0001922)1.95269865
115Progressive muscle weakness (HP:0003323)1.94662648
116Abnormality of vitamin metabolism (HP:0100508)1.94035981
117Increased IgE level (HP:0003212)1.93375461
118Renal Fanconi syndrome (HP:0001994)1.92250656
119Cerebral edema (HP:0002181)1.92087411
120Protuberant abdomen (HP:0001538)1.92075413
121Hypophosphatemia (HP:0002148)1.91623054
122Alkalosis (HP:0001948)1.91452524
123Secondary amenorrhea (HP:0000869)1.89663574
124Myelodysplasia (HP:0002863)1.88445728
125Broad palm (HP:0001169)1.87928342
126Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87863853
127Reduced antithrombin III activity (HP:0001976)1.86978361
128Gastrointestinal dysmotility (HP:0002579)1.86962753
129Sparse eyelashes (HP:0000653)1.86816495
130Tibial bowing (HP:0002982)1.86534474
131Stridor (HP:0010307)1.85898790
132Ulnar bowing (HP:0003031)1.84074835
133Epistaxis (HP:0000421)1.83885528
134Hyperuricemia (HP:0002149)1.83774069
135Increased purine levels (HP:0004368)1.83774069
136Turricephaly (HP:0000262)1.82474874
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81921437
138Abnormal protein N-linked glycosylation (HP:0012347)1.81921437
139Abnormal protein glycosylation (HP:0012346)1.81921437
140Abnormal glycosylation (HP:0012345)1.81921437
141Emotional lability (HP:0000712)1.81307505
142Abnormality of glycolysis (HP:0004366)1.81242104
143Increased serum pyruvate (HP:0003542)1.81242104
144Pigmentary retinal degeneration (HP:0001146)1.79656696
145Hyperammonemia (HP:0001987)1.79225911
146Abnormality of alkaline phosphatase activity (HP:0004379)1.79082239
147Metabolic alkalosis (HP:0200114)1.78753817
148Abnormal tarsal ossification (HP:0008369)1.78381212
149Abnormal enzyme/coenzyme activity (HP:0012379)1.77979161
150Abnormality of the preputium (HP:0100587)1.77697340
151Multiple lipomas (HP:0001012)1.77319068
152Seborrheic dermatitis (HP:0001051)1.75406838
153Nail dystrophy (HP:0008404)1.74490832
154Hypocalcemia (HP:0002901)1.74074144
15511 pairs of ribs (HP:0000878)1.73998068
156Abnormality of macrophages (HP:0004311)1.73543276
157Abnormal spermatogenesis (HP:0008669)1.73282244
158Hypertensive crisis (HP:0100735)1.71552816
159Congenital sensorineural hearing impairment (HP:0008527)1.71316383
160Bowed forearm bones (HP:0003956)1.71267483
161Bowing of the arm (HP:0006488)1.71267483
162Vertebral compression fractures (HP:0002953)1.71200160
163Insomnia (HP:0100785)1.71060772
164Dysostosis multiplex (HP:0000943)1.70932556
165Abnormality of nucleobase metabolism (HP:0010932)1.70287749
166Fragile skin (HP:0001030)1.70275227
167Neonatal onset (HP:0003623)1.69586111
168Focal segmental glomerulosclerosis (HP:0000097)1.69411234
169Abnormality of dental color (HP:0011073)1.66991767
170Microcytic anemia (HP:0001935)1.66527151
171Cholelithiasis (HP:0001081)1.65736528
172Abnormality of magnesium homeostasis (HP:0004921)1.65458923
173Delusions (HP:0000746)1.63491579
174Pendular nystagmus (HP:0012043)1.63218478
175Abnormal gallbladder physiology (HP:0012438)1.62335442
176Cholecystitis (HP:0001082)1.62335442
177Glycosuria (HP:0003076)1.61402667
178Abnormality of urine glucose concentration (HP:0011016)1.61402667
179Paralysis (HP:0003470)1.60891037
180Pterygium (HP:0001059)1.60783273
181Chronic otitis media (HP:0000389)1.59472457
182Slender long bone (HP:0003100)1.58915675
183Bone pain (HP:0002653)1.58908804
184Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.58727193
185Hyperphosphaturia (HP:0003109)1.56805273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.80484886
2ERN15.22240813
3WEE13.66394076
4EIF2AK13.64224213
5PRPF4B3.48541328
6MST1R3.29681125
7EPHA23.12049917
8STK163.06807439
9CDC72.95395509
10SCYL22.90333314
11BUB12.81486421
12VRK12.73878498
13PIM22.50766782
14NEK12.48201904
15NME12.39800186
16RIPK12.32227661
17CDK122.25292821
18DYRK32.14136927
19ACVR1B2.13146652
20NEK22.11942390
21CDK192.09814302
22SIK12.09226919
23EPHB21.94211904
24SMG11.92506936
25RPS6KA41.88079372
26KDR1.83412223
27FGFR41.78480051
28BRSK21.75357640
29SRPK11.70714252
30MET1.67761625
31KSR21.65438019
32EPHB11.61772444
33ICK1.57447923
34LRRK21.55493895
35BCKDK1.55493321
36PRKG21.54126371
37EPHA31.53808377
38IRAK31.50723647
39PDK21.48545214
40EIF2AK31.46132487
41TYK21.43337482
42MAP3K111.38083428
43MAP3K91.36954821
44MAPKAPK51.36369814
45MAP3K11.29869252
46CDK81.28476919
47IRAK21.22487423
48DDR21.21845374
49MAP3K101.21230749
50AURKB1.20984652
51PLK11.20781347
52EEF2K1.17359900
53CCNB11.17210585
54MAP3K21.15765496
55CDK71.14227511
56PIK3CG1.13090828
57ABL21.11240638
58ATR1.10135127
59TLK11.09612580
60AURKA1.09083542
61MAP3K71.09067182
62TNIK1.08956318
63CDK41.07725892
64IRAK11.05160374
65DYRK1B1.03394195
66RPS6KB21.02841689
67TTK1.02746106
68BRSK11.02670463
69MAP4K11.01280806
70PTK60.99290698
71MAP3K80.97135703
72TGFBR10.94036532
73STK100.93549148
74FLT30.93261513
75PDPK10.92161741
76LMTK20.89821405
77RAF10.88995167
78BMX0.88960288
79MAP3K30.88627451
80GRK60.88329624
81PTK20.85915640
82SIK30.85737667
83PDGFRA0.84399050
84MAP2K20.83811629
85MAP3K130.82541788
86MUSK0.80244909
87MAPKAPK30.78557356
88TSSK60.77573082
89MKNK10.77456505
90CSNK2A10.76796022
91TYRO30.76398506
92PBK0.75913888
93MAP2K30.74885671
94CDC42BPA0.73729988
95NTRK10.73615475
96CSNK2A20.72941550
97IRAK40.72379148
98DAPK10.71097180
99RPS6KA20.70658093
100JAK20.70543498
101TGFBR20.70460179
102TAOK10.70425972
103CHEK20.68590630
104MAP3K60.65705557
105PINK10.65618269
106PLK40.65037209
107PRKCI0.64871646
108PAK40.63938815
109STK240.62456638
110KIT0.61885909
111JAK30.60817869
112TESK10.60295071
113MTOR0.60033698
114RPS6KC10.58001893
115RPS6KL10.58001893
116MOS0.57962397
117ILK0.57574915
118PIM10.56765857
119BRAF0.54263394
120RPS6KA50.53041904
121CSNK1G30.52829126
122ATM0.51249151
123MATK0.50853261
124TBK10.49947072
125SIK20.49652053
126CHEK10.49218281
127PRKD20.48209062
128MAP2K70.47752421
129HIPK20.46039600
130TRIB30.45807731
131MYLK0.45686021
132LYN0.43175632
133RPS6KA60.43165585
134EIF2AK20.41881806
135ARAF0.41457983
136CSK0.41318870
137CHUK0.39758438
138RIPK40.39251786
139PRKCZ0.38865957
140PDK10.38598873
141TAOK20.37924156
142BTK0.37458305
143MAPK110.37291045
144PKN20.36894795
145MAP2K60.36616641
146TEC0.36340662
147PASK0.35797352
148PRKD10.35712588
149CDK20.33647150
150IKBKB0.32003796
151MAPK120.31864914
152ZAP700.30979769
153TESK20.30797362
154DYRK20.30748329
155AKT20.29820831
156MARK20.29490712
157PAK10.29246834
158RET0.29207760
159GRK10.28102477
160CAMK2G0.26960320
161CAMKK20.26890415
162RPS6KB10.26669296
163PDK40.26250511
164PDK30.26250511
165CSNK1G10.25943296
166MST40.25438373
167STK40.25358508

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.27070154
2Ribosome_Homo sapiens_hsa030105.02496518
3Mismatch repair_Homo sapiens_hsa034303.42141058
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.41862965
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.40925461
6Proteasome_Homo sapiens_hsa030503.35264270
7RNA polymerase_Homo sapiens_hsa030202.95749257
8Pyrimidine metabolism_Homo sapiens_hsa002402.95084357
9Mineral absorption_Homo sapiens_hsa049782.86757158
10Base excision repair_Homo sapiens_hsa034102.69000983
11Nucleotide excision repair_Homo sapiens_hsa034202.62185331
12Parkinsons disease_Homo sapiens_hsa050122.58555162
13Spliceosome_Homo sapiens_hsa030402.56644672
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54981276
15Other glycan degradation_Homo sapiens_hsa005112.45327926
16Oxidative phosphorylation_Homo sapiens_hsa001902.41743604
17Homologous recombination_Homo sapiens_hsa034402.21902199
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04960139
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94469050
20RNA transport_Homo sapiens_hsa030131.94387858
21Arginine biosynthesis_Homo sapiens_hsa002201.93985324
22One carbon pool by folate_Homo sapiens_hsa006701.89902768
23Sulfur relay system_Homo sapiens_hsa041221.84370774
24Folate biosynthesis_Homo sapiens_hsa007901.83408216
25Huntingtons disease_Homo sapiens_hsa050161.82955312
26Cell cycle_Homo sapiens_hsa041101.73135918
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66729475
28PPAR signaling pathway_Homo sapiens_hsa033201.64828558
29Non-homologous end-joining_Homo sapiens_hsa034501.64682739
30Glycerolipid metabolism_Homo sapiens_hsa005611.58658183
31Purine metabolism_Homo sapiens_hsa002301.57672712
32Protein export_Homo sapiens_hsa030601.55432690
33RNA degradation_Homo sapiens_hsa030181.54957189
34Starch and sucrose metabolism_Homo sapiens_hsa005001.54703373
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54144577
36Alzheimers disease_Homo sapiens_hsa050101.52594797
37Sulfur metabolism_Homo sapiens_hsa009201.49312213
38Fanconi anemia pathway_Homo sapiens_hsa034601.45157380
39Pentose phosphate pathway_Homo sapiens_hsa000301.39749378
40Histidine metabolism_Homo sapiens_hsa003401.36685732
41Chemical carcinogenesis_Homo sapiens_hsa052041.33716081
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29129277
43p53 signaling pathway_Homo sapiens_hsa041151.28901326
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28397379
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.28213055
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.24060206
47Basal transcription factors_Homo sapiens_hsa030221.21205393
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20849382
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19917494
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16786453
51Caffeine metabolism_Homo sapiens_hsa002321.13777851
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13639957
53Bile secretion_Homo sapiens_hsa049761.12252126
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09560476
55Ether lipid metabolism_Homo sapiens_hsa005651.01888508
56Retinol metabolism_Homo sapiens_hsa008300.95258806
57Glutathione metabolism_Homo sapiens_hsa004800.93357735
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.92338716
59N-Glycan biosynthesis_Homo sapiens_hsa005100.89343080
60Selenocompound metabolism_Homo sapiens_hsa004500.87264219
61Pyruvate metabolism_Homo sapiens_hsa006200.86434374
62Cardiac muscle contraction_Homo sapiens_hsa042600.85656124
63Carbon metabolism_Homo sapiens_hsa012000.84901425
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.83193571
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83170848
66Phenylalanine metabolism_Homo sapiens_hsa003600.82981907
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77514719
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.76750731
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76582003
70Asthma_Homo sapiens_hsa053100.76330157
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74966009
72Biosynthesis of amino acids_Homo sapiens_hsa012300.73263031
73Prion diseases_Homo sapiens_hsa050200.71664559
74Metabolic pathways_Homo sapiens_hsa011000.70223636
75Herpes simplex infection_Homo sapiens_hsa051680.67342007
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63415123
77Hepatitis C_Homo sapiens_hsa051600.61137021
78Epstein-Barr virus infection_Homo sapiens_hsa051690.59105822
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58871162
80Staphylococcus aureus infection_Homo sapiens_hsa051500.57202444
81Hematopoietic cell lineage_Homo sapiens_hsa046400.55934239
82Peroxisome_Homo sapiens_hsa041460.54178055
83Propanoate metabolism_Homo sapiens_hsa006400.52447350
84Systemic lupus erythematosus_Homo sapiens_hsa053220.52384244
85GnRH signaling pathway_Homo sapiens_hsa049120.49453376
86Salmonella infection_Homo sapiens_hsa051320.49338305
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46936090
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45927755
89Leishmaniasis_Homo sapiens_hsa051400.44689514
90mRNA surveillance pathway_Homo sapiens_hsa030150.44053943
91Allograft rejection_Homo sapiens_hsa053300.43747744
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42725418
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.42716293
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39822354
95Antigen processing and presentation_Homo sapiens_hsa046120.39200273
96Insulin resistance_Homo sapiens_hsa049310.38875676
97Toxoplasmosis_Homo sapiens_hsa051450.37762169
98Tyrosine metabolism_Homo sapiens_hsa003500.36872672
99Oocyte meiosis_Homo sapiens_hsa041140.35115767
100Viral carcinogenesis_Homo sapiens_hsa052030.34602885
101Legionellosis_Homo sapiens_hsa051340.34133320
102Fatty acid elongation_Homo sapiens_hsa000620.33952931
103Fatty acid degradation_Homo sapiens_hsa000710.33451431
104Autoimmune thyroid disease_Homo sapiens_hsa053200.33430686
105Tryptophan metabolism_Homo sapiens_hsa003800.30906463
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30128989
107Linoleic acid metabolism_Homo sapiens_hsa005910.29206277
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.28288644
109Chronic myeloid leukemia_Homo sapiens_hsa052200.27708409
110Fat digestion and absorption_Homo sapiens_hsa049750.27525483
111Notch signaling pathway_Homo sapiens_hsa043300.27473456
112Apoptosis_Homo sapiens_hsa042100.27441653
113Insulin signaling pathway_Homo sapiens_hsa049100.26522797
114ABC transporters_Homo sapiens_hsa020100.25931408
115Fatty acid biosynthesis_Homo sapiens_hsa000610.25548921
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24879562
117TNF signaling pathway_Homo sapiens_hsa046680.23591962
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23166749
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23161349
120beta-Alanine metabolism_Homo sapiens_hsa004100.22839571
121Thyroid cancer_Homo sapiens_hsa052160.22580457
122Small cell lung cancer_Homo sapiens_hsa052220.22482868
123Influenza A_Homo sapiens_hsa051640.22148314
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21827634
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20903805
126Hepatitis B_Homo sapiens_hsa051610.20388765
127Galactose metabolism_Homo sapiens_hsa000520.20027141
128Graft-versus-host disease_Homo sapiens_hsa053320.19790760
129Arachidonic acid metabolism_Homo sapiens_hsa005900.19306389
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19094099
131Arginine and proline metabolism_Homo sapiens_hsa003300.19035181
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18029480
133Renin-angiotensin system_Homo sapiens_hsa046140.17790816
134ErbB signaling pathway_Homo sapiens_hsa040120.17542985
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.16424251
136Pertussis_Homo sapiens_hsa051330.14477061
137Pancreatic secretion_Homo sapiens_hsa049720.13772734
138AMPK signaling pathway_Homo sapiens_hsa041520.13671530
139Inositol phosphate metabolism_Homo sapiens_hsa005620.13225532
140HTLV-I infection_Homo sapiens_hsa051660.12647162
141Choline metabolism in cancer_Homo sapiens_hsa052310.12252441
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.11295876
143Measles_Homo sapiens_hsa051620.11048727
144Lysosome_Homo sapiens_hsa041420.10591132
145Shigellosis_Homo sapiens_hsa051310.10560320
146Protein digestion and absorption_Homo sapiens_hsa049740.09391145
147Alcoholism_Homo sapiens_hsa050340.07489428
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07285424
149Bladder cancer_Homo sapiens_hsa052190.06797704
150Sphingolipid metabolism_Homo sapiens_hsa006000.06221497
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05297661
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.04303616
153Fructose and mannose metabolism_Homo sapiens_hsa000510.04297434
154Fatty acid metabolism_Homo sapiens_hsa012120.04061027
155Acute myeloid leukemia_Homo sapiens_hsa052210.02908689
156Vitamin digestion and absorption_Homo sapiens_hsa049770.02652960
157VEGF signaling pathway_Homo sapiens_hsa043700.00740276
158Tuberculosis_Homo sapiens_hsa051520.00675214
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.00361029

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