FAM127C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)4.44545918
2type B pancreatic cell proliferation (GO:0044342)4.04051916
3extracellular fibril organization (GO:0043206)3.68752799
4COPI coating of Golgi vesicle (GO:0048205)3.59618508
5Golgi transport vesicle coating (GO:0048200)3.59618508
6positive regulation of actin filament depolymerization (GO:0030836)3.54909100
7protein retention in ER lumen (GO:0006621)3.35272340
8protein heterotrimerization (GO:0070208)3.25336571
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.03289263
10kidney mesenchyme development (GO:0072074)2.94319221
11mitotic nuclear envelope reassembly (GO:0007084)2.91879131
12nuclear envelope reassembly (GO:0031468)2.91879131
13positive regulation of mitochondrial fission (GO:0090141)2.84370919
14chaperone-mediated protein transport (GO:0072321)2.79633583
15lipopolysaccharide biosynthetic process (GO:0009103)2.78563576
16muscle cell migration (GO:0014812)2.77816174
17sequestering of actin monomers (GO:0042989)2.75029607
18pyrimidine nucleobase catabolic process (GO:0006208)2.70446499
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70107559
20fibril organization (GO:0097435)2.67143203
21negative regulation of JAK-STAT cascade (GO:0046426)2.65492426
22cullin deneddylation (GO:0010388)2.65344981
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63095604
24proteasome assembly (GO:0043248)2.62446309
25protein deneddylation (GO:0000338)2.61652317
26positive regulation of TOR signaling (GO:0032008)2.60513618
27pattern specification involved in kidney development (GO:0061004)2.59932978
28axon extension involved in axon guidance (GO:0048846)2.58803933
29neuron projection extension involved in neuron projection guidance (GO:1902284)2.58803933
30ganglion development (GO:0061548)2.57327770
31collagen fibril organization (GO:0030199)2.51126956
32metanephric mesenchyme development (GO:0072075)2.45896719
33negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.45889360
34metallo-sulfur cluster assembly (GO:0031163)2.44534206
35iron-sulfur cluster assembly (GO:0016226)2.44534206
36regulation of mitochondrial translation (GO:0070129)2.44007569
37negative regulation of axon extension involved in axon guidance (GO:0048843)2.42642067
38G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.42044465
39negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.41756710
40cochlea morphogenesis (GO:0090103)2.41413946
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.39843591
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.38715657
43positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.38155889
44barbed-end actin filament capping (GO:0051016)2.37083197
45positive regulation of protein depolymerization (GO:1901881)2.35864193
46GTP biosynthetic process (GO:0006183)2.34463781
47endocardial cushion development (GO:0003197)2.32725781
48response to gravity (GO:0009629)2.32348855
49regulation of integrin-mediated signaling pathway (GO:2001044)2.31527296
50skin morphogenesis (GO:0043589)2.31422122
51mesonephros development (GO:0001823)2.30886325
52regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.26991333
53negative regulation of axon guidance (GO:1902668)2.26204892
54establishment of protein localization to mitochondrial membrane (GO:0090151)2.24114603
55protein complex biogenesis (GO:0070271)2.23876949
56response to redox state (GO:0051775)2.23484423
57ventricular cardiac muscle cell development (GO:0055015)2.21971905
58positive regulation of protein complex disassembly (GO:0043243)2.21668017
59negative regulation of embryonic development (GO:0045992)2.20802717
60guanosine-containing compound biosynthetic process (GO:1901070)2.20689053
61middle ear morphogenesis (GO:0042474)2.20398446
62outflow tract septum morphogenesis (GO:0003148)2.18513274
63negative regulation of cell size (GO:0045792)2.18163790
64actin filament depolymerization (GO:0030042)2.18110411
65embryonic skeletal joint morphogenesis (GO:0060272)2.12437830
66outer ear morphogenesis (GO:0042473)2.10848119
67sequestering of extracellular ligand from receptor (GO:0035581)2.10778412
68negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.09723626
69bone trabecula formation (GO:0060346)2.09578410
70growth hormone secretion (GO:0030252)2.08801478
71positive regulation of protein targeting to membrane (GO:0090314)2.08737500
72pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.08363275
73positive regulation of synapse assembly (GO:0051965)2.07890516
74regulation of axon extension involved in axon guidance (GO:0048841)2.07876466
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.07837884
76mitochondrial respiratory chain complex I assembly (GO:0032981)2.07837884
77NADH dehydrogenase complex assembly (GO:0010257)2.07837884
78UTP biosynthetic process (GO:0006228)2.07556666
79regulation of cardioblast differentiation (GO:0051890)2.07272600
80axonal fasciculation (GO:0007413)2.07121236
81substrate-dependent cell migration (GO:0006929)2.04851722
82positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.04498070
83positive regulation of axon extension (GO:0045773)2.04074577
84axon extension (GO:0048675)2.03885015
85uterus development (GO:0060065)2.03824737
86negative regulation of chondrocyte differentiation (GO:0032331)2.03254752
87tooth mineralization (GO:0034505)2.03156061
88CTP biosynthetic process (GO:0006241)2.02312462
89CTP metabolic process (GO:0046036)2.02312462
90mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.02179480
91substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.01699338
92substrate-independent telencephalic tangential migration (GO:0021826)2.01699338
93norepinephrine metabolic process (GO:0042415)2.01485306
94regulation of axon guidance (GO:1902667)2.01330717
95regulation of gonadotropin secretion (GO:0032276)2.00751095
96mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.00291327
97positive regulation of cartilage development (GO:0061036)1.99840949
98pyrimidine nucleoside triphosphate metabolic process (GO:0009147)1.98631241
99regulation of secondary heart field cardioblast proliferation (GO:0003266)1.98114522
100regulation of cardioblast proliferation (GO:0003264)1.98114522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.40164659
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.31294271
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24382517
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89254388
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.81561117
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51258112
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42425971
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29172217
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23147263
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.22251155
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.21583148
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15683165
13PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.11422286
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.08968998
15CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.04638034
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.02672346
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95160194
18ZNF263_19887448_ChIP-Seq_K562_Human1.89799148
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.88394511
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.85546262
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78213675
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71365451
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71008387
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.68140864
25GABP_19822575_ChIP-Seq_HepG2_Human1.67923676
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66196162
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64883363
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63491313
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61733548
30TP53_20018659_ChIP-ChIP_R1E_Mouse1.59149451
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57858033
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57496504
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52865403
34XRN2_22483619_ChIP-Seq_HELA_Human1.52367296
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50125952
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50125952
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.49599046
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49034825
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45819050
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.41932970
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.41639152
42* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38960125
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38855613
44DCP1A_22483619_ChIP-Seq_HELA_Human1.38003645
45CTCF_18555785_ChIP-Seq_MESCs_Mouse1.37630709
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37262563
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33824039
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33724530
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33413693
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32605343
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31973013
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.31559390
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30284023
54MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.26960161
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25836929
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24884399
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24682253
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24217584
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24027840
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22323064
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.22308724
62TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.21299081
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18538057
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.17904202
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15799789
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15743292
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15511488
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14055656
69SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13124621
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12420291
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12239844
72CLOCK_20551151_ChIP-Seq_293T_Human1.10818287
73TTF2_22483619_ChIP-Seq_HELA_Human1.10749904
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10192357
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.06287575
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.05861460
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04208126
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.03929489
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03621867
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.02360633
81FOXP1_21924763_ChIP-Seq_HESCs_Human1.02356317
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02125449
83SOX17_20123909_ChIP-Seq_XEN_Mouse1.00835116
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00550191
85TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99899952
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99115818
87SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99061157
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98578138
89ERG_21242973_ChIP-ChIP_JURKAT_Human0.97878160
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96855193
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95204651
92ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94604216
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94030063
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93484928
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.93154440
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93078737
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91000630
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90714759
99RNF2_27304074_Chip-Seq_ESCs_Mouse0.90166235
100SA1_22415368_ChIP-Seq_MEFs_Mouse0.89989892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.28631244
2MP0010030_abnormal_orbit_morphology3.24569569
3MP0004272_abnormal_basement_membrane2.71914719
4MP0005623_abnormal_meninges_morphology2.68064272
5MP0005503_abnormal_tendon_morphology2.61607825
6MP0001542_abnormal_bone_strength2.42582216
7MP0005257_abnormal_intraocular_pressure2.36626154
8MP0000751_myopathy2.19272488
9MP0003279_aneurysm2.17211527
10MP0005275_abnormal_skin_tensile2.06275587
11MP0000049_abnormal_middle_ear2.04487685
12MP0001529_abnormal_vocalization2.03847439
13MP0000013_abnormal_adipose_tissue1.96735592
14MP0002234_abnormal_pharynx_morphology1.88388185
15MP0000534_abnormal_ureter_morphology1.82946314
16MP0003942_abnormal_urinary_system1.82131878
17MP0010368_abnormal_lymphatic_system1.81801115
18MP0005508_abnormal_skeleton_morphology1.64304539
19MP0000750_abnormal_muscle_regeneration1.63965343
20MP0008789_abnormal_olfactory_epithelium1.63887585
21MP0001299_abnormal_eye_distance/1.63460054
22MP0009384_cardiac_valve_regurgitation1.55654349
23MP0009250_abnormal_appendicular_skeleto1.48493887
24MP0003705_abnormal_hypodermis_morpholog1.45237842
25MP0001958_emphysema1.45200824
26MP0000749_muscle_degeneration1.44553150
27MP0002249_abnormal_larynx_morphology1.43714965
28MP0009780_abnormal_chondrocyte_physiolo1.41266636
29MP0003385_abnormal_body_wall1.40263576
30MP0009053_abnormal_anal_canal1.38378535
31MP0002877_abnormal_melanocyte_morpholog1.31662898
32MP0002282_abnormal_trachea_morphology1.31559222
33MP0000516_abnormal_urinary_system1.27875182
34MP0005367_renal/urinary_system_phenotyp1.27875182
35MP0005187_abnormal_penis_morphology1.27827691
36MP0006276_abnormal_autonomic_nervous1.27204112
37MP0002295_abnormal_pulmonary_circulatio1.23298147
38MP0002938_white_spotting1.22384451
39MP0003315_abnormal_perineum_morphology1.21421574
40MP0002177_abnormal_outer_ear1.17155060
41MP0000003_abnormal_adipose_tissue1.16209180
42MP0004858_abnormal_nervous_system1.16032711
43MP0005499_abnormal_olfactory_system1.15643751
44MP0005394_taste/olfaction_phenotype1.15643751
45MP0003123_paternal_imprinting1.13548096
46MP0002837_dystrophic_cardiac_calcinosis1.13112884
47MP0001905_abnormal_dopamine_level1.11470393
48MP0004134_abnormal_chest_morphology1.10915218
49MP0000778_abnormal_nervous_system1.10627054
50MP0004233_abnormal_muscle_weight1.10295448
51MP0000462_abnormal_digestive_system1.08298876
52MP0003119_abnormal_digestive_system1.07490275
53MP0000647_abnormal_sebaceous_gland1.07344775
54MP0002102_abnormal_ear_morphology1.06693936
55MP0002751_abnormal_autonomic_nervous1.06685967
56MP0002233_abnormal_nose_morphology1.04434140
57MP0001879_abnormal_lymphatic_vessel1.04388874
58MP0003755_abnormal_palate_morphology1.03487821
59MP0002108_abnormal_muscle_morphology1.02626313
60MP0008932_abnormal_embryonic_tissue1.01514385
61MP0000762_abnormal_tongue_morphology0.98983286
62MP0006054_spinal_hemorrhage0.97929372
63MP0000163_abnormal_cartilage_morphology0.97657863
64MP0003566_abnormal_cell_adhesion0.96156087
65MP0010386_abnormal_urinary_bladder0.93476868
66MP0003186_abnormal_redox_activity0.91599309
67MP0003880_abnormal_central_pattern0.91473276
68MP0001243_abnormal_dermal_layer0.91034036
69MP0003937_abnormal_limbs/digits/tail_de0.90729474
70MP0002653_abnormal_ependyma_morphology0.89442510
71MP0002736_abnormal_nociception_after0.88434229
72MP0003122_maternal_imprinting0.87860062
73MP0002932_abnormal_joint_morphology0.84953611
74MP0005646_abnormal_pituitary_gland0.83806132
75MP0002116_abnormal_craniofacial_bone0.83403080
76MP0004859_abnormal_synaptic_plasticity0.82532699
77MP0005197_abnormal_uvea_morphology0.81985360
78MP0002184_abnormal_innervation0.81964078
79MP0000639_abnormal_adrenal_gland0.81410120
80MP0000538_abnormal_urinary_bladder0.80902829
81MP0003121_genomic_imprinting0.80094952
82MP0002822_catalepsy0.79537530
83MP0001270_distended_abdomen0.79013373
84MP0003935_abnormal_craniofacial_develop0.78424279
85MP0005171_absent_coat_pigmentation0.77639016
86MP0000759_abnormal_skeletal_muscle0.77093395
87MP0000537_abnormal_urethra_morphology0.76305468
88MP0002909_abnormal_adrenal_gland0.76065966
89MP0005330_cardiomyopathy0.75945504
90MP0002060_abnormal_skin_morphology0.75451021
91MP0003115_abnormal_respiratory_system0.75011553
92MP0002160_abnormal_reproductive_system0.74899262
93MP0002697_abnormal_eye_size0.69541359
94MP0002114_abnormal_axial_skeleton0.68923102
95MP0000767_abnormal_smooth_muscle0.68676853
96MP0001340_abnormal_eyelid_morphology0.68350515
97MP0000681_abnormal_thyroid_gland0.67773703
98MP0002896_abnormal_bone_mineralization0.66696012
99MP0000733_abnormal_muscle_development0.64950499
100MP0005193_abnormal_anterior_eye0.62289043

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.52486752
2Protrusio acetabuli (HP:0003179)3.74572781
3Follicular hyperkeratosis (HP:0007502)3.36506610
4Abnormality of dentin (HP:0010299)3.11707619
5Spinal rigidity (HP:0003306)2.95480316
6Ankle contracture (HP:0006466)2.84876959
7Bladder diverticulum (HP:0000015)2.83526731
8Soft skin (HP:0000977)2.60644932
9Morphological abnormality of the middle ear (HP:0008609)2.44583897
10Atrophic scars (HP:0001075)2.44168171
11Long toe (HP:0010511)2.41043075
12Hand muscle atrophy (HP:0009130)2.37451348
13Hypoventilation (HP:0002791)2.31545811
14Vertebral compression fractures (HP:0002953)2.25815642
15Aortic dissection (HP:0002647)2.25507653
16Type 1 muscle fiber predominance (HP:0003803)2.24187553
17Upper limb amyotrophy (HP:0009129)2.21108887
18Distal upper limb amyotrophy (HP:0007149)2.21108887
19Adrenal hypoplasia (HP:0000835)2.19730842
20Acute necrotizing encephalopathy (HP:0006965)2.17506785
21Delayed gross motor development (HP:0002194)2.16654422
22Abnormal mitochondria in muscle tissue (HP:0008316)2.14936902
23Bowel diverticulosis (HP:0005222)2.14023401
24Short nail (HP:0001799)2.11526728
25Hydroureter (HP:0000072)2.08774362
26Pulmonary artery stenosis (HP:0004415)2.08757229
27Short clavicles (HP:0000894)2.06182498
28Aplasia/Hypoplasia of the clavicles (HP:0006710)2.04389984
29Vascular tortuosity (HP:0004948)2.02800596
30Abnormality of the umbilical cord (HP:0010881)2.02737471
31Mildly elevated creatine phosphokinase (HP:0008180)2.01080895
32Infantile muscular hypotonia (HP:0008947)2.00543970
33Microglossia (HP:0000171)2.00052640
34Hypoplastic left heart (HP:0004383)1.98258463
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98001758
36Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98001758
37Retinal dysplasia (HP:0007973)1.97307015
38Unilateral renal agenesis (HP:0000122)1.93177038
39Renal Fanconi syndrome (HP:0001994)1.93061152
40Wormian bones (HP:0002645)1.93058844
41Buphthalmos (HP:0000557)1.89181963
42Wrist flexion contracture (HP:0001239)1.89036095
43Generalized amyotrophy (HP:0003700)1.88676723
44Congenital glaucoma (HP:0001087)1.88623876
45Failure to thrive in infancy (HP:0001531)1.87388898
46Hyperacusis (HP:0010780)1.87073080
47Entropion (HP:0000621)1.85667773
48Renal dysplasia (HP:0000110)1.84727173
49Mitochondrial inheritance (HP:0001427)1.83659105
50Breech presentation (HP:0001623)1.81253854
51Limb-girdle muscle weakness (HP:0003325)1.80341257
52Down-sloping shoulders (HP:0200021)1.79654944
53Cervical subluxation (HP:0003308)1.75921275
54Slender build (HP:0001533)1.75677396
55Overriding aorta (HP:0002623)1.74275072
56Polyphagia (HP:0002591)1.73687360
57Redundant skin (HP:0001582)1.73048307
58Abnormality of the fetal cardiovascular system (HP:0010948)1.72253512
59Abnormal umbilical cord blood vessels (HP:0011403)1.72253512
60Single umbilical artery (HP:0001195)1.72253512
61Achilles tendon contracture (HP:0001771)1.71662738
62Fragile skin (HP:0001030)1.71046858
63Bell-shaped thorax (HP:0001591)1.70219115
64Upper limb muscle weakness (HP:0003484)1.69918170
65Arterial tortuosity (HP:0005116)1.69365606
66Elbow flexion contracture (HP:0002987)1.69023251
67Limb-girdle muscle atrophy (HP:0003797)1.67601471
68Shoulder girdle muscle weakness (HP:0003547)1.67461400
69Bradycardia (HP:0001662)1.66885228
70Hypoplastic heart (HP:0001961)1.64891018
71Hallux valgus (HP:0001822)1.64865073
72Adducted thumb (HP:0001181)1.64704332
73Shallow orbits (HP:0000586)1.64521178
74Acute encephalopathy (HP:0006846)1.64386569
75Progressive macrocephaly (HP:0004481)1.63656894
76Abnormality of the musculature of the pelvis (HP:0001469)1.63593811
77Abnormality of the hip-girdle musculature (HP:0001445)1.63593811
78Renal duplication (HP:0000075)1.60664193
79Deviation of the hallux (HP:0010051)1.59118384
80Abnormal delivery (HP:0001787)1.58869913
81Hyperextensible skin (HP:0000974)1.55376429
82Occipital encephalocele (HP:0002085)1.53275742
83Abnormality of the anterior chamber (HP:0000593)1.52405772
84Reduced subcutaneous adipose tissue (HP:0003758)1.52182530
85Deformed tarsal bones (HP:0008119)1.50567151
86Opisthotonus (HP:0002179)1.50502018
87Hepatocellular necrosis (HP:0001404)1.49956090
88Joint laxity (HP:0001388)1.49785180
89Dental crowding (HP:0000678)1.49379420
90Double outlet right ventricle (HP:0001719)1.48597272
91Congenital malformation of the right heart (HP:0011723)1.48597272
92Hepatic necrosis (HP:0002605)1.46964468
93Abnormality of the distal phalanges of the toes (HP:0010182)1.45466502
94Severe muscular hypotonia (HP:0006829)1.45372374
95Insomnia (HP:0100785)1.44565870
96Round ear (HP:0100830)1.44060923
97Abnormality of the phalanges of the hallux (HP:0010057)1.43892916
98Increased serum pyruvate (HP:0003542)1.42861934
99Abnormalities of placenta or umbilical cord (HP:0001194)1.42760111
100Osteopenia (HP:0000938)1.42540351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.83024981
2LIMK14.34078908
3BCKDK2.53131220
4TESK22.48589494
5VRK22.45462120
6MAP2K72.41633355
7MYLK2.36063836
8LMTK22.23787672
9TRIM282.20341707
10PIM22.06921936
11NME22.06430008
12EPHB22.04176151
13EPHA21.84490475
14CSNK1G31.80389690
15ARAF1.74230851
16BUB11.72414484
17MARK11.71157196
18CSNK1A1L1.54162509
19BCR1.53192550
20STK161.50319774
21ABL21.47912127
22PTK21.45831724
23CSNK1G11.44250936
24CDK191.39621813
25CSNK1G21.37639315
26MAP3K41.30377217
27MAP3K121.29557639
28ILK1.26589810
29SCYL21.23453099
30MAPKAPK31.22293524
31DYRK21.20786039
32MAP3K61.19379787
33PAK41.15497368
34DDR21.08113220
35PKN21.07784415
36PHKG21.03878580
37PHKG11.03878580
38SRPK11.03302253
39NTRK10.94661494
40CAMK2G0.93625590
41KDR0.90111695
42PDGFRA0.89840400
43MAP4K20.86911944
44ERBB30.83850226
45PAK20.79774038
46CDK140.78112426
47MINK10.76850311
48CDK180.76371977
49CAMK2D0.74994106
50WNK30.73975190
51MAP3K110.73376673
52TRIB30.73223041
53NEK10.72157385
54CDK150.70838308
55TAOK20.70510172
56CDK11A0.70290860
57PAK60.69740759
58ROCK20.68897950
59CAMK2B0.67905011
60AURKA0.67036464
61MAP2K40.66952423
62IRAK30.66825016
63CDK80.65823651
64ERBB40.64792774
65TTN0.63938469
66PDK20.63733745
67GRK50.63629077
68GRK70.63108194
69DYRK30.62906764
70DAPK30.61455991
71DMPK0.60750985
72ADRBK10.60574178
73FER0.60568568
74PAK10.59509023
75RPS6KA20.59081546
76BRSK10.58864547
77EPHA40.57982348
78ROCK10.57739971
79PTK2B0.56924608
80PLK20.56901051
81PBK0.56772375
82MUSK0.55695923
83FLT30.55237163
84PRKCI0.53515444
85PRKCE0.53249140
86PRKD20.51038523
87MOS0.50631365
88DYRK1B0.49667193
89CCNB10.49330953
90PRKD10.48962976
91SIK10.48635494
92CDK70.48390270
93PINK10.48228813
94PRKG20.47865922
95CASK0.47754541
96BRAF0.47666409
97TIE10.43650993
98CAMK2A0.41490198
99DAPK10.41053306
100LATS10.40504987

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.44734085
2Proteasome_Homo sapiens_hsa030502.32108414
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31731665
4Fatty acid elongation_Homo sapiens_hsa000622.29069451
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.24666697
6Parkinsons disease_Homo sapiens_hsa050122.15500183
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06965615
8Sulfur relay system_Homo sapiens_hsa041222.02938477
9Vibrio cholerae infection_Homo sapiens_hsa051102.02537300
10Protein export_Homo sapiens_hsa030601.90951039
11Folate biosynthesis_Homo sapiens_hsa007901.85798273
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75309219
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68214588
14RNA polymerase_Homo sapiens_hsa030201.68036531
15Huntingtons disease_Homo sapiens_hsa050161.63447964
16Steroid biosynthesis_Homo sapiens_hsa001001.58533424
17Alzheimers disease_Homo sapiens_hsa050101.49937631
18Pyrimidine metabolism_Homo sapiens_hsa002401.45885500
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45007502
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42427781
21Cardiac muscle contraction_Homo sapiens_hsa042601.42347217
22Synaptic vesicle cycle_Homo sapiens_hsa047211.32684060
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32257162
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31590197
25ECM-receptor interaction_Homo sapiens_hsa045121.30391299
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29377711
27Base excision repair_Homo sapiens_hsa034101.27253940
28Dilated cardiomyopathy_Homo sapiens_hsa054141.19764792
29Hippo signaling pathway_Homo sapiens_hsa043901.14935658
30Biosynthesis of amino acids_Homo sapiens_hsa012301.13717873
31Pentose phosphate pathway_Homo sapiens_hsa000301.11840042
32Glutathione metabolism_Homo sapiens_hsa004801.11394147
33Basal cell carcinoma_Homo sapiens_hsa052171.10331566
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08784205
35Hedgehog signaling pathway_Homo sapiens_hsa043401.08677638
36Axon guidance_Homo sapiens_hsa043601.06846900
37Collecting duct acid secretion_Homo sapiens_hsa049661.05512965
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05450543
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05077557
40Sulfur metabolism_Homo sapiens_hsa009201.04537606
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04438447
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99789836
43Galactose metabolism_Homo sapiens_hsa000520.99298782
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97630328
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96424841
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95742944
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93897763
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.93037531
49Cocaine addiction_Homo sapiens_hsa050300.91533472
50N-Glycan biosynthesis_Homo sapiens_hsa005100.91144270
51Nucleotide excision repair_Homo sapiens_hsa034200.83845938
52Focal adhesion_Homo sapiens_hsa045100.81894017
53Carbon metabolism_Homo sapiens_hsa012000.80882116
54Vitamin B6 metabolism_Homo sapiens_hsa007500.79359592
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79270029
56Gap junction_Homo sapiens_hsa045400.74751962
57Purine metabolism_Homo sapiens_hsa002300.74311571
58Pyruvate metabolism_Homo sapiens_hsa006200.74028890
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73219833
60Fructose and mannose metabolism_Homo sapiens_hsa000510.71180092
61Melanoma_Homo sapiens_hsa052180.69654900
62AMPK signaling pathway_Homo sapiens_hsa041520.68485650
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68191484
64DNA replication_Homo sapiens_hsa030300.66275355
65Basal transcription factors_Homo sapiens_hsa030220.65936162
66Metabolic pathways_Homo sapiens_hsa011000.65113768
67Dopaminergic synapse_Homo sapiens_hsa047280.65008656
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64699873
69Tight junction_Homo sapiens_hsa045300.64040922
70Ribosome_Homo sapiens_hsa030100.62742474
71Mismatch repair_Homo sapiens_hsa034300.62176894
72Shigellosis_Homo sapiens_hsa051310.60726096
73Spliceosome_Homo sapiens_hsa030400.56698036
74Fatty acid metabolism_Homo sapiens_hsa012120.56403221
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56050143
76Arginine and proline metabolism_Homo sapiens_hsa003300.55560908
77GABAergic synapse_Homo sapiens_hsa047270.54380507
78TGF-beta signaling pathway_Homo sapiens_hsa043500.54042767
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52181003
80Lysosome_Homo sapiens_hsa041420.51632130
81Melanogenesis_Homo sapiens_hsa049160.50319792
82Peroxisome_Homo sapiens_hsa041460.50073456
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49648157
84Wnt signaling pathway_Homo sapiens_hsa043100.48803953
85Fanconi anemia pathway_Homo sapiens_hsa034600.47033252
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45894035
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45409565
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45357378
89beta-Alanine metabolism_Homo sapiens_hsa004100.45122618
90Protein digestion and absorption_Homo sapiens_hsa049740.44931854
91Propanoate metabolism_Homo sapiens_hsa006400.44557171
92Endocytosis_Homo sapiens_hsa041440.43309554
93Tyrosine metabolism_Homo sapiens_hsa003500.42373212
94Proteoglycans in cancer_Homo sapiens_hsa052050.42310057
95Butanoate metabolism_Homo sapiens_hsa006500.41678330
96Regulation of autophagy_Homo sapiens_hsa041400.41265089
97RNA transport_Homo sapiens_hsa030130.41062364
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.40652421
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.39577535
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.39059498

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »