FAM127B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)3.89730875
2protein maturation by protein folding (GO:0022417)3.78087317
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78014618
4proteasome assembly (GO:0043248)3.71334515
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53011319
6ATP synthesis coupled proton transport (GO:0015986)3.44979376
7energy coupled proton transport, down electrochemical gradient (GO:0015985)3.44979376
8protein complex biogenesis (GO:0070271)3.44657947
9establishment of protein localization to mitochondrial membrane (GO:0090151)3.40885016
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35787190
11positive regulation of mitochondrial fission (GO:0090141)3.34507425
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.30405622
13NADH dehydrogenase complex assembly (GO:0010257)3.30405622
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30405622
15protein neddylation (GO:0045116)3.25096976
16cullin deneddylation (GO:0010388)3.22600922
17mitochondrial respiratory chain complex assembly (GO:0033108)3.18934755
18respiratory electron transport chain (GO:0022904)3.13309479
19electron transport chain (GO:0022900)3.10649110
20protein deneddylation (GO:0000338)3.03576588
21establishment of integrated proviral latency (GO:0075713)3.01989976
22regulation of mitochondrial translation (GO:0070129)2.98532311
23GTP biosynthetic process (GO:0006183)2.98263714
24protein targeting to mitochondrion (GO:0006626)2.97454721
25nuclear envelope reassembly (GO:0031468)2.97439876
26mitotic nuclear envelope reassembly (GO:0007084)2.97439876
27establishment of protein localization to mitochondrion (GO:0072655)2.83751792
28establishment of viral latency (GO:0019043)2.83064527
29guanosine-containing compound biosynthetic process (GO:1901070)2.76135714
30protein localization to mitochondrion (GO:0070585)2.74622585
31protein retention in ER lumen (GO:0006621)2.72933120
32sequestering of actin monomers (GO:0042989)2.70958218
33metallo-sulfur cluster assembly (GO:0031163)2.69073455
34iron-sulfur cluster assembly (GO:0016226)2.69073455
35UTP biosynthetic process (GO:0006228)2.68675899
36DNA damage response, detection of DNA damage (GO:0042769)2.65531524
37termination of RNA polymerase III transcription (GO:0006386)2.61488811
38transcription elongation from RNA polymerase III promoter (GO:0006385)2.61488811
39pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.60065708
40CTP metabolic process (GO:0046036)2.57152960
41CTP biosynthetic process (GO:0006241)2.57152960
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.56805883
43L-serine metabolic process (GO:0006563)2.55786609
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55099219
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55099219
46pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50221312
47response to gravity (GO:0009629)2.49154440
48positive regulation of actin filament depolymerization (GO:0030836)2.48766034
49peptidyl-histidine modification (GO:0018202)2.46606785
50positive regulation of TOR signaling (GO:0032008)2.46084868
51oxidative phosphorylation (GO:0006119)2.45637388
52UTP metabolic process (GO:0046051)2.45585080
53establishment of mitochondrion localization (GO:0051654)2.45263045
54pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.44759471
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.42031031
56purine nucleoside triphosphate biosynthetic process (GO:0009145)2.41096024
57peptidyl-arginine omega-N-methylation (GO:0035247)2.40205382
58spliceosomal snRNP assembly (GO:0000387)2.38853423
59pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.38067914
60base-excision repair, AP site formation (GO:0006285)2.36989759
61mannosylation (GO:0097502)2.36221154
62regulation of cellular amino acid metabolic process (GO:0006521)2.35957227
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.34935543
64respiratory chain complex IV assembly (GO:0008535)2.33145720
65substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.31571157
66substrate-independent telencephalic tangential migration (GO:0021826)2.31571157
67protein insertion into membrane (GO:0051205)2.31128525
68pyrimidine nucleobase catabolic process (GO:0006208)2.30020017
69ribonucleoside triphosphate biosynthetic process (GO:0009201)2.28707312
70L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.27525388
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.24920075
72histone arginine methylation (GO:0034969)2.24492200
73postsynaptic membrane organization (GO:0001941)2.24343561
74ATP biosynthetic process (GO:0006754)2.24273342
75pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.22664573
76protein-cofactor linkage (GO:0018065)2.19804662
77lipopolysaccharide biosynthetic process (GO:0009103)2.19198531
78negative regulation of ligase activity (GO:0051352)2.18434572
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.18434572
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.17910787
81cerebellar Purkinje cell layer development (GO:0021680)2.17632847
82ATP hydrolysis coupled proton transport (GO:0015991)2.17352772
83energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.17352772
84C-terminal protein lipidation (GO:0006501)2.15258990
85nucleoside triphosphate biosynthetic process (GO:0009142)2.13652301
86regulation of mitochondrial fission (GO:0090140)2.13140269
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.12996549
88hydrogen ion transmembrane transport (GO:1902600)2.12724252
89cytochrome complex assembly (GO:0017004)2.12318928
90branched-chain amino acid catabolic process (GO:0009083)2.12062632
91negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.11528880
92cell migration in hindbrain (GO:0021535)2.11098857
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.09890049
94regulation of cilium movement (GO:0003352)2.09085423
95positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.06117708
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.04860997
97peptidyl-arginine methylation (GO:0018216)2.04189278
98peptidyl-arginine N-methylation (GO:0035246)2.04189278
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.03962689
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.03962689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.28057841
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.56593736
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.30771034
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29173146
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24032843
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.91538183
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.91414577
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.84718908
9THAP11_20581084_ChIP-Seq_MESCs_Mouse2.84175499
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69328282
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.60338129
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57983297
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.54128155
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44644076
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34903720
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.31874669
17XRN2_22483619_ChIP-Seq_HELA_Human2.30875452
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29852650
19CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.20003616
20GABP_19822575_ChIP-Seq_HepG2_Human2.16258510
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03575407
22E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99586444
23CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.97890145
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97239129
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87752771
26DCP1A_22483619_ChIP-Seq_HELA_Human1.84547039
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.80565246
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.78916157
29ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77260192
30TTF2_22483619_ChIP-Seq_HELA_Human1.71674521
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.64151291
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62500563
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61278029
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60627162
35CTCF_18555785_ChIP-Seq_MESCs_Mouse1.54833529
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52961446
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46618824
38DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45473328
39SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.44998738
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43943691
41KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41748919
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39545420
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35668917
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35169426
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34318369
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.32538347
47FOXP1_21924763_ChIP-Seq_HESCs_Human1.29606319
48KDM5A_27292631_Chip-Seq_BREAST_Human1.29346270
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28615227
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27141533
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25121702
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24233265
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.23390264
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22131287
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21355450
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20855795
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19852322
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.14855350
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.13508242
60VDR_23849224_ChIP-Seq_CD4+_Human1.13263857
61FOXP3_21729870_ChIP-Seq_TREG_Human1.12261992
62ZNF263_19887448_ChIP-Seq_K562_Human1.11824085
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10173164
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09914917
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09632918
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09328164
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09067421
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08990163
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.08657629
70CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08554043
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07589262
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06524592
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06413892
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04283425
75TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.03811908
76SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02951200
77TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98693679
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97341296
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97049225
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95502350
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94691586
82ERG_21242973_ChIP-ChIP_JURKAT_Human0.94098526
83MYC_18940864_ChIP-ChIP_HL60_Human0.94029377
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93827096
85* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91509503
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.91276606
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90618879
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.90517032
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89797108
90OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89182950
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87702855
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87110925
93ELK1_19687146_ChIP-ChIP_HELA_Human0.86110542
94ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84416923
95P68_20966046_ChIP-Seq_HELA_Human0.83594924
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83353533
97REST_18959480_ChIP-ChIP_MESCs_Mouse0.81960799
98EOMES_21245162_ChIP-Seq_HESCs_Human0.81880275
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81487500
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80543281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology2.79078980
2MP0003880_abnormal_central_pattern2.47228500
3MP0003123_paternal_imprinting2.42218252
4MP0001529_abnormal_vocalization2.27323409
5MP0002234_abnormal_pharynx_morphology2.02471012
6MP0008789_abnormal_olfactory_epithelium1.99942002
7MP0004859_abnormal_synaptic_plasticity1.92621681
8MP0000049_abnormal_middle_ear1.91989277
9MP0006292_abnormal_olfactory_placode1.82358594
10MP0002653_abnormal_ependyma_morphology1.78068604
11MP0002249_abnormal_larynx_morphology1.75079511
12MP0003186_abnormal_redox_activity1.70734784
13MP0005499_abnormal_olfactory_system1.68770372
14MP0005394_taste/olfaction_phenotype1.68770372
15MP0006276_abnormal_autonomic_nervous1.63637294
16MP0005423_abnormal_somatic_nervous1.61734494
17MP0005623_abnormal_meninges_morphology1.61154044
18MP0000516_abnormal_urinary_system1.57041980
19MP0005367_renal/urinary_system_phenotyp1.57041980
20MP0002736_abnormal_nociception_after1.55609935
21MP0000778_abnormal_nervous_system1.54847747
22MP0003122_maternal_imprinting1.48896429
23MP0003942_abnormal_urinary_system1.48092720
24MP0005646_abnormal_pituitary_gland1.46719997
25MP0004133_heterotaxia1.46426937
26MP0002822_catalepsy1.45741131
27MP0001188_hyperpigmentation1.45592326
28MP0003121_genomic_imprinting1.44156975
29MP0002938_white_spotting1.41920916
30MP0003136_yellow_coat_color1.38976790
31MP0001905_abnormal_dopamine_level1.37108988
32MP0008932_abnormal_embryonic_tissue1.36033872
33MP0000751_myopathy1.28242083
34MP0005670_abnormal_white_adipose1.24673151
35MP0000750_abnormal_muscle_regeneration1.24502605
36MP0001542_abnormal_bone_strength1.20541838
37MP0003119_abnormal_digestive_system1.20144951
38MP0001968_abnormal_touch/_nociception1.16813444
39MP0004270_analgesia1.16713274
40MP0003786_premature_aging1.16185545
41MP0002751_abnormal_autonomic_nervous1.15302350
42MP0008058_abnormal_DNA_repair1.14199914
43MP0003011_delayed_dark_adaptation1.13108646
44MP0001984_abnormal_olfaction1.12963971
45MP0002102_abnormal_ear_morphology1.12005097
46MP0006036_abnormal_mitochondrial_physio1.10335189
47MP0008995_early_reproductive_senescence1.10196977
48MP0002557_abnormal_social/conspecific_i1.09819605
49MP0000534_abnormal_ureter_morphology1.08885753
50MP0005257_abnormal_intraocular_pressure1.06133786
51MP0002572_abnormal_emotion/affect_behav1.03860871
52MP0003635_abnormal_synaptic_transmissio1.03560751
53MP0000631_abnormal_neuroendocrine_gland1.02971863
54MP0003315_abnormal_perineum_morphology1.02638825
55MP0002734_abnormal_mechanical_nocicepti1.02325839
56MP0004858_abnormal_nervous_system1.00838403
57MP0002233_abnormal_nose_morphology0.99428055
58MP0001299_abnormal_eye_distance/0.97297512
59MP0001293_anophthalmia0.96718313
60MP0002272_abnormal_nervous_system0.96641645
61MP0003755_abnormal_palate_morphology0.96459007
62MP0002282_abnormal_trachea_morphology0.95438043
63MP0000955_abnormal_spinal_cord0.95382162
64MP0009053_abnormal_anal_canal0.95343500
65MP0003938_abnormal_ear_development0.95210408
66MP0002184_abnormal_innervation0.95138499
67MP0004272_abnormal_basement_membrane0.92474134
68MP0005187_abnormal_penis_morphology0.92252644
69MP0005171_absent_coat_pigmentation0.92141996
70MP0006035_abnormal_mitochondrial_morpho0.91493693
71MP0009745_abnormal_behavioral_response0.90877016
72MP0002177_abnormal_outer_ear0.90702580
73MP0000537_abnormal_urethra_morphology0.90135789
74MP0003787_abnormal_imprinting0.90135241
75MP0003937_abnormal_limbs/digits/tail_de0.90038345
76MP0009046_muscle_twitch0.89041340
77MP0003137_abnormal_impulse_conducting0.88748664
78MP0000749_muscle_degeneration0.88262132
79MP0002837_dystrophic_cardiac_calcinosis0.87800174
80MP0003861_abnormal_nervous_system0.87781112
81MP0000026_abnormal_inner_ear0.87327124
82MP0009250_abnormal_appendicular_skeleto0.87017658
83MP0000358_abnormal_cell_content/0.86504969
84MP0009780_abnormal_chondrocyte_physiolo0.84850199
85MP0002752_abnormal_somatic_nervous0.84848138
86MP0002733_abnormal_thermal_nociception0.84510169
87MP0006072_abnormal_retinal_apoptosis0.83977340
88MP0002063_abnormal_learning/memory/cond0.82939853
89MP0002697_abnormal_eye_size0.82660135
90MP0002882_abnormal_neuron_morphology0.82086933
91MP0003385_abnormal_body_wall0.81942674
92MP0005508_abnormal_skeleton_morphology0.81144922
93MP0004811_abnormal_neuron_physiology0.80985875
94MP0001970_abnormal_pain_threshold0.79709319
95MP0004147_increased_porphyrin_level0.79485411
96MP0002163_abnormal_gland_morphology0.76564073
97MP0002064_seizures0.76502159
98MP0000762_abnormal_tongue_morphology0.76240893
99MP0002152_abnormal_brain_morphology0.75304157
100MP0000647_abnormal_sebaceous_gland0.74009984

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.03433372
2Abnormal mitochondria in muscle tissue (HP:0008316)3.86211936
3Mitochondrial inheritance (HP:0001427)3.56989022
4Acute encephalopathy (HP:0006846)3.52909564
5Progressive macrocephaly (HP:0004481)3.29471570
6Hepatocellular necrosis (HP:0001404)3.16849298
7Increased CSF lactate (HP:0002490)3.00066050
8Renal Fanconi syndrome (HP:0001994)2.98511594
9Hepatic necrosis (HP:0002605)2.98112060
10Retinal dysplasia (HP:0007973)2.67149265
11Increased hepatocellular lipid droplets (HP:0006565)2.61642474
12Myokymia (HP:0002411)2.59951251
13Abnormality of glycolysis (HP:0004366)2.56861650
14Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56559036
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56559036
16Hypoplastic left heart (HP:0004383)2.51117955
17Increased serum pyruvate (HP:0003542)2.43849995
18Cerebral edema (HP:0002181)2.37169605
19Adrenal hypoplasia (HP:0000835)2.34048527
20Hand muscle atrophy (HP:0009130)2.32279382
21Exercise intolerance (HP:0003546)2.28322788
22Lipid accumulation in hepatocytes (HP:0006561)2.26369505
23Gait imbalance (HP:0002141)2.26301912
24Cerebral hypomyelination (HP:0006808)2.23857651
25Lactic acidosis (HP:0003128)2.20732182
26Poor suck (HP:0002033)2.18195936
27Medial flaring of the eyebrow (HP:0010747)2.16269462
28Congenital primary aphakia (HP:0007707)2.14872363
29Increased intramyocellular lipid droplets (HP:0012240)2.14529722
30Hypoplastic pelvis (HP:0008839)2.13650858
31Hyperglycinemia (HP:0002154)2.12818977
32Abnormality of the umbilical cord (HP:0010881)2.12021828
33Nephrogenic diabetes insipidus (HP:0009806)2.08731545
34Delayed CNS myelination (HP:0002188)2.08263129
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06925851
36Abnormal umbilical cord blood vessels (HP:0011403)2.06796731
37Single umbilical artery (HP:0001195)2.06796731
38Abnormality of the fetal cardiovascular system (HP:0010948)2.06796731
39Degeneration of anterior horn cells (HP:0002398)2.06412771
40Abnormality of the anterior horn cell (HP:0006802)2.06412771
41Respiratory failure (HP:0002878)2.05274051
42Congenital malformation of the right heart (HP:0011723)2.04791612
43Double outlet right ventricle (HP:0001719)2.04791612
44Polyphagia (HP:0002591)2.04126878
45Hypoplastic heart (HP:0001961)2.01012850
46Opisthotonus (HP:0002179)1.98354761
47Concave nail (HP:0001598)1.97261978
48Increased serum lactate (HP:0002151)1.92970001
49Cholecystitis (HP:0001082)1.92087440
50Abnormal gallbladder physiology (HP:0012438)1.92087440
51Sclerocornea (HP:0000647)1.91193932
52Down-sloping shoulders (HP:0200021)1.90465424
53Emotional lability (HP:0000712)1.86797451
54Upper limb amyotrophy (HP:0009129)1.86072017
55Distal upper limb amyotrophy (HP:0007149)1.86072017
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85238586
57Type I transferrin isoform profile (HP:0003642)1.83945033
58Microretrognathia (HP:0000308)1.83777196
59Testicular atrophy (HP:0000029)1.80994639
60Methylmalonic aciduria (HP:0012120)1.80855311
61Increased muscle lipid content (HP:0009058)1.79127078
62Severe muscular hypotonia (HP:0006829)1.75854276
63Upper limb muscle weakness (HP:0003484)1.75591921
64Methylmalonic acidemia (HP:0002912)1.75569490
65X-linked dominant inheritance (HP:0001423)1.75259278
66Exertional dyspnea (HP:0002875)1.74927776
67Hypokinesia (HP:0002375)1.72409670
68Occipital encephalocele (HP:0002085)1.72096473
69Abnormal number of erythroid precursors (HP:0012131)1.70238645
70Optic disc pallor (HP:0000543)1.69695552
71True hermaphroditism (HP:0010459)1.65124874
72Leukodystrophy (HP:0002415)1.64908020
73Delayed gross motor development (HP:0002194)1.64566105
74Muscle fiber atrophy (HP:0100295)1.59306850
75Abnormality of dentin (HP:0010299)1.58928943
76Hydroureter (HP:0000072)1.57338719
77Microvesicular hepatic steatosis (HP:0001414)1.56816121
78Abnormality of the aortic arch (HP:0012303)1.56209907
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.55084104
80Abnormal protein N-linked glycosylation (HP:0012347)1.55084104
81Abnormal protein glycosylation (HP:0012346)1.55084104
82Abnormal glycosylation (HP:0012345)1.55084104
83Aplasia/hypoplasia of the uterus (HP:0008684)1.54870840
84Renal dysplasia (HP:0000110)1.54367433
85Abnormalities of placenta or umbilical cord (HP:0001194)1.53311829
86Hyperthyroidism (HP:0000836)1.52851239
87Abnormal number of incisors (HP:0011064)1.52634014
88Dental crowding (HP:0000678)1.52284895
89Preaxial hand polydactyly (HP:0001177)1.50932739
90Broad distal phalanx of finger (HP:0009836)1.50430617
91Abnormality of renal resorption (HP:0011038)1.50173629
92Postnatal microcephaly (HP:0005484)1.49579630
93Cortical dysplasia (HP:0002539)1.49216668
94Abnormal hemoglobin (HP:0011902)1.49182114
95Abnormality of cells of the erythroid lineage (HP:0012130)1.48750950
96Vaginal atresia (HP:0000148)1.48282271
97Optic nerve coloboma (HP:0000588)1.48129503
98Genital tract atresia (HP:0001827)1.47971657
99Lethargy (HP:0001254)1.47833375
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.47724998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.59475214
2TESK13.66829749
3LIMK13.26102442
4NME23.08001602
5BCKDK2.79506775
6TESK22.49475436
7STK162.22314318
8TRIM282.14433269
9MAP2K72.07529939
10MARK12.01041677
11CSNK1G31.96996746
12BUB11.90177152
13PIM21.88684756
14DYRK21.74836801
15CSNK1G21.69388563
16EPHA21.67478701
17CSNK1A1L1.61731467
18PRKD31.53103192
19ARAF1.52580089
20LMTK21.50209105
21EPHB21.49624644
22CSNK1G11.44399436
23DAPK11.42365500
24NEK11.42120325
25SRPK11.37843608
26CASK1.36292708
27BRSK11.32773896
28MAP4K21.26820549
29MINK11.21359086
30WNK31.20308103
31PBK1.15447738
32BCR1.15361405
33ABL21.13398296
34ILK1.11901606
35EIF2AK11.09822459
36EPHA41.06674143
37DYRK31.06597063
38VRK11.04018542
39MUSK1.01667729
40NME10.97828642
41PAK60.96871383
42TNIK0.96833281
43MAP3K40.95797658
44CCNB10.95081411
45MAP3K120.92535858
46PDK20.92372046
47AURKA0.89691428
48DAPK30.88584914
49CDK140.83316443
50PHKG20.82949667
51PHKG10.82949667
52CDK190.82081599
53PTK20.81400545
54PLK30.78744596
55GRK50.77333615
56NUAK10.77021937
57PAK40.76750868
58CDK180.76364731
59PLK20.75534522
60MYLK0.75169816
61SIK30.74827677
62CDK11A0.73878937
63PRKCI0.71810154
64CDK150.71242517
65BRAF0.70491368
66PAK30.69903069
67PRKCG0.68509566
68PINK10.68232773
69CAMK2G0.64910758
70WEE10.64905204
71PRKD20.63243956
72CDC70.60834881
73CDK80.60672167
74MAP3K110.60274301
75LRRK20.59322014
76PLK10.59261191
77DAPK20.58495984
78UHMK10.56182466
79CAMK2B0.54866153
80TAF10.54603693
81AKT20.53465750
82NTRK10.53161013
83CAMK2D0.51442721
84ERBB40.50517391
85PAK10.49487531
86INSRR0.47135601
87KDR0.46567146
88CDK70.45634110
89CSNK1A10.45344584
90MAPK150.43386604
91PRKCE0.42988578
92AURKB0.42884118
93MAPKAPK50.42787088
94SIK10.42710370
95MAPKAPK30.41505750
96MAPK130.39821493
97DYRK1B0.39609271
98ROCK20.39454582
99FER0.39056640
100CDK50.38823780

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.33890378
2Parkinsons disease_Homo sapiens_hsa050122.94546561
3Proteasome_Homo sapiens_hsa030502.73245108
4Ribosome_Homo sapiens_hsa030102.43417130
5Sulfur relay system_Homo sapiens_hsa041222.37522720
6Fatty acid elongation_Homo sapiens_hsa000622.31056231
7Huntingtons disease_Homo sapiens_hsa050162.18945399
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99970184
9RNA polymerase_Homo sapiens_hsa030201.97602874
10Folate biosynthesis_Homo sapiens_hsa007901.96760810
11Base excision repair_Homo sapiens_hsa034101.94782422
12Alzheimers disease_Homo sapiens_hsa050101.94264035
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93638365
14Protein export_Homo sapiens_hsa030601.86979483
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78777516
16Cardiac muscle contraction_Homo sapiens_hsa042601.61036943
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56491601
18Pyrimidine metabolism_Homo sapiens_hsa002401.51170321
19Biosynthesis of amino acids_Homo sapiens_hsa012301.50123399
20DNA replication_Homo sapiens_hsa030301.46399372
21Vibrio cholerae infection_Homo sapiens_hsa051101.45555380
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43652985
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43349244
24Synaptic vesicle cycle_Homo sapiens_hsa047211.43019632
25Pyruvate metabolism_Homo sapiens_hsa006201.40628651
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38963087
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38009277
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36521620
29Glutathione metabolism_Homo sapiens_hsa004801.34414476
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29720868
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27670900
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27658949
33Mismatch repair_Homo sapiens_hsa034301.23370973
34Carbon metabolism_Homo sapiens_hsa012001.22203708
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.15562942
36Spliceosome_Homo sapiens_hsa030401.13987029
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.13330433
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12228302
39Steroid biosynthesis_Homo sapiens_hsa001001.10295023
40Collecting duct acid secretion_Homo sapiens_hsa049661.09289079
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07252224
42Pentose phosphate pathway_Homo sapiens_hsa000301.01815612
43Propanoate metabolism_Homo sapiens_hsa006401.01165921
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00793849
45Vitamin B6 metabolism_Homo sapiens_hsa007501.00436557
46Nucleotide excision repair_Homo sapiens_hsa034200.98742270
47Purine metabolism_Homo sapiens_hsa002300.92720625
48Arginine and proline metabolism_Homo sapiens_hsa003300.91910050
49Basal transcription factors_Homo sapiens_hsa030220.87763590
50Cocaine addiction_Homo sapiens_hsa050300.86347350
51Homologous recombination_Homo sapiens_hsa034400.85909640
52Basal cell carcinoma_Homo sapiens_hsa052170.85208203
53Metabolic pathways_Homo sapiens_hsa011000.84627146
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83570974
55Galactose metabolism_Homo sapiens_hsa000520.83530203
56beta-Alanine metabolism_Homo sapiens_hsa004100.83504957
57Fanconi anemia pathway_Homo sapiens_hsa034600.81422512
58Fructose and mannose metabolism_Homo sapiens_hsa000510.81141016
59Butanoate metabolism_Homo sapiens_hsa006500.80325130
60RNA transport_Homo sapiens_hsa030130.79087158
61Nicotine addiction_Homo sapiens_hsa050330.78841414
62Peroxisome_Homo sapiens_hsa041460.77934001
63Hedgehog signaling pathway_Homo sapiens_hsa043400.74791470
64N-Glycan biosynthesis_Homo sapiens_hsa005100.73173415
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69969018
66Hippo signaling pathway_Homo sapiens_hsa043900.68337654
67Regulation of autophagy_Homo sapiens_hsa041400.66534410
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65686399
69One carbon pool by folate_Homo sapiens_hsa006700.64689463
70Selenocompound metabolism_Homo sapiens_hsa004500.63389099
71GABAergic synapse_Homo sapiens_hsa047270.59065362
72Sulfur metabolism_Homo sapiens_hsa009200.58459226
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.58253057
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56350862
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56097672
76Phenylalanine metabolism_Homo sapiens_hsa003600.55702819
77RNA degradation_Homo sapiens_hsa030180.54618923
78Axon guidance_Homo sapiens_hsa043600.54103121
79Dopaminergic synapse_Homo sapiens_hsa047280.53227831
80Phototransduction_Homo sapiens_hsa047440.51856522
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50612237
82Tyrosine metabolism_Homo sapiens_hsa003500.50334423
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47814368
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45675714
85Insulin secretion_Homo sapiens_hsa049110.42982973
86Fatty acid metabolism_Homo sapiens_hsa012120.42269358
87Amphetamine addiction_Homo sapiens_hsa050310.40649527
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38725446
89Wnt signaling pathway_Homo sapiens_hsa043100.36738360
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36495765
91Oocyte meiosis_Homo sapiens_hsa041140.35787672
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35702134
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35575752
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30519856
95Tight junction_Homo sapiens_hsa045300.30320437
96Melanogenesis_Homo sapiens_hsa049160.30285846
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.30119348
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29750065
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29712230
100Non-homologous end-joining_Homo sapiens_hsa034500.28623311

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