FAM122C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.80555751
2reproduction (GO:0000003)9.70078517
3axonemal dynein complex assembly (GO:0070286)9.54671098
4spermatid development (GO:0007286)9.54309287
5motile cilium assembly (GO:0044458)9.13469397
6regulation of cilium movement (GO:0003352)8.62629480
7cilium or flagellum-dependent cell motility (GO:0001539)8.35241313
8cilium movement (GO:0003341)7.87389521
9single fertilization (GO:0007338)7.60687671
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.45433558
11synaptonemal complex organization (GO:0070193)6.90972321
12synaptonemal complex assembly (GO:0007130)6.89567416
13male meiosis (GO:0007140)6.88246276
14piRNA metabolic process (GO:0034587)6.80959609
15sperm capacitation (GO:0048240)6.72540554
16spermatogenesis (GO:0007283)6.63791397
17male gamete generation (GO:0048232)6.61453385
18microtubule depolymerization (GO:0007019)6.60905219
19negative regulation of inclusion body assembly (GO:0090084)6.51199948
20organic cation transport (GO:0015695)6.47988432
21fertilization (GO:0009566)6.41020889
22gamete generation (GO:0007276)6.07955798
23behavioral response to nicotine (GO:0035095)6.02262849
24ventricular system development (GO:0021591)5.55622558
25regulation of inclusion body assembly (GO:0090083)5.49940153
26calcium ion-dependent exocytosis (GO:0017156)5.34351912
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.31442599
28germ cell development (GO:0007281)5.31420262
29glycerol ether metabolic process (GO:0006662)5.16794003
30chromosome condensation (GO:0030261)5.15769454
31regulation of microtubule-based movement (GO:0060632)5.10019223
32microtubule severing (GO:0051013)5.01397162
33cell recognition (GO:0008037)4.98430256
34spermatid nucleus differentiation (GO:0007289)4.94358383
35DNA packaging (GO:0006323)4.80637357
36seminiferous tubule development (GO:0072520)4.78908913
37multicellular organismal reproductive process (GO:0048609)4.78804912
38ether metabolic process (GO:0018904)4.77421679
39chromosome organization involved in meiosis (GO:0070192)4.76543956
40fucose catabolic process (GO:0019317)4.44865559
41L-fucose metabolic process (GO:0042354)4.44865559
42L-fucose catabolic process (GO:0042355)4.44865559
43DNA methylation involved in gamete generation (GO:0043046)4.44476662
44male meiosis I (GO:0007141)4.41541029
45sequestering of actin monomers (GO:0042989)4.21951870
46sexual reproduction (GO:0019953)4.20508175
47single strand break repair (GO:0000012)4.07583521
48meiotic nuclear division (GO:0007126)4.07018360
49chaperone-mediated protein complex assembly (GO:0051131)4.05365082
50DNA deamination (GO:0045006)4.02053680
51multicellular organismal development (GO:0007275)3.91923522
52genitalia morphogenesis (GO:0035112)3.88783003
53response to pheromone (GO:0019236)3.81046236
54left/right pattern formation (GO:0060972)3.77827859
55indolalkylamine metabolic process (GO:0006586)3.72719705
56protein K11-linked deubiquitination (GO:0035871)3.71620813
57protein polyglutamylation (GO:0018095)3.65731382
58monoubiquitinated protein deubiquitination (GO:0035520)3.60089322
59meiosis I (GO:0007127)3.50233953
60nucleoside diphosphate phosphorylation (GO:0006165)3.45769838
61protein-cofactor linkage (GO:0018065)3.43981605
62tryptophan catabolic process (GO:0006569)3.41246861
63indole-containing compound catabolic process (GO:0042436)3.41246861
64indolalkylamine catabolic process (GO:0046218)3.41246861
65glycolytic process (GO:0006096)3.39912357
66microtubule polymerization or depolymerization (GO:0031109)3.38483044
67GTP biosynthetic process (GO:0006183)3.37532022
68ubiquinone biosynthetic process (GO:0006744)3.35324768
69negative regulation of telomere maintenance (GO:0032205)3.33937825
70meiotic chromosome segregation (GO:0045132)3.31566129
71platelet dense granule organization (GO:0060155)3.30781745
72preassembly of GPI anchor in ER membrane (GO:0016254)3.28676830
73protein localization to cilium (GO:0061512)3.27912615
74meiotic cell cycle (GO:0051321)3.27477571
75neural tube formation (GO:0001841)3.27095083
76tryptophan metabolic process (GO:0006568)3.17793772
77regulation of spindle checkpoint (GO:0090231)3.17202224
78water-soluble vitamin biosynthetic process (GO:0042364)3.16566335
79polyol catabolic process (GO:0046174)3.16500990
80detection of light stimulus involved in visual perception (GO:0050908)3.13589327
81detection of light stimulus involved in sensory perception (GO:0050962)3.13589327
82kynurenine metabolic process (GO:0070189)3.13383780
83cellular ketone body metabolic process (GO:0046950)3.10664545
84ubiquinone metabolic process (GO:0006743)3.10152702
85reciprocal DNA recombination (GO:0035825)3.09783151
86reciprocal meiotic recombination (GO:0007131)3.09783151
87interferon-gamma secretion (GO:0072643)3.07775694
88mitochondrial respiratory chain complex I assembly (GO:0032981)3.07724405
89NADH dehydrogenase complex assembly (GO:0010257)3.07724405
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07724405
91cornea development in camera-type eye (GO:0061303)3.06920229
92UTP biosynthetic process (GO:0006228)3.06398399
93alditol metabolic process (GO:0019400)3.06231720
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05475163
95regulation of response to osmotic stress (GO:0047484)3.05004760
96base-excision repair, AP site formation (GO:0006285)3.04944793
97nucleus organization (GO:0006997)3.04209048
98regulation of meiosis I (GO:0060631)3.03357012
99protein complex biogenesis (GO:0070271)3.02264131
100mitotic sister chromatid cohesion (GO:0007064)2.99718023
101cellular response to ATP (GO:0071318)2.95266561
102replication fork processing (GO:0031297)2.94303766
103recombinational repair (GO:0000725)2.92355952
104nonmotile primary cilium assembly (GO:0035058)2.92225576
105double-strand break repair via homologous recombination (GO:0000724)2.91198700
106synaptic transmission, cholinergic (GO:0007271)2.91012307
107protein refolding (GO:0042026)2.87763680
108regulation of rhodopsin mediated signaling pathway (GO:0022400)2.86423235
109lactate metabolic process (GO:0006089)2.86060590
110mitochondrial respiratory chain complex assembly (GO:0033108)2.83967014
111ketone body metabolic process (GO:1902224)2.82206534
112synapsis (GO:0007129)2.82203044
113carnitine transport (GO:0015879)2.81902401
114amino-acid betaine transport (GO:0015838)2.81902401
115somite development (GO:0061053)2.80984742
116UTP metabolic process (GO:0046051)2.77576174
117regulation of nuclear cell cycle DNA replication (GO:0033262)2.77479135
118ATP synthesis coupled proton transport (GO:0015986)2.75197319
119energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75197319
120rhodopsin mediated signaling pathway (GO:0016056)2.75192437
121phosphatidylinositol acyl-chain remodeling (GO:0036149)2.74960522
122cilium organization (GO:0044782)2.74299507
123indole-containing compound metabolic process (GO:0042430)2.72997264
124sulfation (GO:0051923)2.72523662
125RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71464947
126cellular component assembly involved in morphogenesis (GO:0010927)2.70908037
127regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.69135299
128protein K6-linked ubiquitination (GO:0085020)2.68943847
129meiotic cell cycle process (GO:1903046)2.68614039
130protein localization to chromosome, centromeric region (GO:0071459)2.67762472
131protein neddylation (GO:0045116)2.67410146
132respiratory chain complex IV assembly (GO:0008535)2.66851271
133carnitine transmembrane transport (GO:1902603)2.66495436
134mannosylation (GO:0097502)2.64531656
135positive regulation of macrophage activation (GO:0043032)2.64527513
136cilium assembly (GO:0042384)2.63837457
137microtubule-based movement (GO:0007018)2.63693280
138somite rostral/caudal axis specification (GO:0032525)2.62422770
139photoreceptor cell development (GO:0042461)2.61387392
140regulation of cilium assembly (GO:1902017)2.61157155
141centriole replication (GO:0007099)2.60904934
142glycerol metabolic process (GO:0006071)2.60719040
143RNA localization (GO:0006403)2.60416056
144cilium morphogenesis (GO:0060271)2.60006417
145amine catabolic process (GO:0009310)2.59829305
146cellular biogenic amine catabolic process (GO:0042402)2.59829305
147rRNA catabolic process (GO:0016075)2.59200334
148endoderm formation (GO:0001706)2.58259881
149chromatin silencing (GO:0006342)2.56204983
150negative regulation of mast cell activation (GO:0033004)2.53674424
151quinone biosynthetic process (GO:1901663)2.52600657
152pyrimidine nucleobase catabolic process (GO:0006208)2.51754130
153nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51608104
154retinal cone cell development (GO:0046549)2.51101496
155intraciliary transport (GO:0042073)2.50781130
156photoreceptor cell maintenance (GO:0045494)2.50008525
157cell redox homeostasis (GO:0045454)2.49804687
158regulation of action potential (GO:0098900)2.49291734
159pseudouridine synthesis (GO:0001522)2.47312157
160DNA demethylation (GO:0080111)2.46476851
161axoneme assembly (GO:0035082)2.45450519
162resolution of meiotic recombination intermediates (GO:0000712)2.43615067
163behavioral response to ethanol (GO:0048149)2.43604853
164gene silencing by RNA (GO:0031047)2.43220010
165negative regulation of DNA-dependent DNA replication (GO:2000104)2.43141725
166mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42587732
167kidney morphogenesis (GO:0060993)2.42343218
168somatic hypermutation of immunoglobulin genes (GO:0016446)2.42124609
169somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42124609
170phosphatidylserine acyl-chain remodeling (GO:0036150)2.41480872
171exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39517791
172primary amino compound metabolic process (GO:1901160)2.39233631
173fusion of sperm to egg plasma membrane (GO:0007342)14.2961557
174sperm motility (GO:0030317)13.8957868
175cell wall macromolecule metabolic process (GO:0044036)13.1968679
176cell wall macromolecule catabolic process (GO:0016998)13.1968679
177acrosome assembly (GO:0001675)12.6120859
178acrosome reaction (GO:0007340)11.6191253
179sperm-egg recognition (GO:0035036)11.5535119
180multicellular organism reproduction (GO:0032504)11.2709861
181plasma membrane fusion (GO:0045026)10.8790729
182binding of sperm to zona pellucida (GO:0007339)10.6596413
183cell-cell recognition (GO:0009988)10.3317458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.90245277
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.16830327
3EZH2_22144423_ChIP-Seq_EOC_Human4.00286995
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.42564067
5IGF1R_20145208_ChIP-Seq_DFB_Human3.01302541
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.85916170
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76265650
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.74156095
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67126827
10GBX2_23144817_ChIP-Seq_PC3_Human2.54204612
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.42405350
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39786701
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35997033
14VDR_22108803_ChIP-Seq_LS180_Human2.31732030
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.25595862
16EWS_26573619_Chip-Seq_HEK293_Human2.23510672
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.16466558
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15393030
19FUS_26573619_Chip-Seq_HEK293_Human2.12134008
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.10858636
21GATA1_26923725_Chip-Seq_HPCs_Mouse2.08363494
22CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.07647564
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.04560160
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02125048
25ZNF274_21170338_ChIP-Seq_K562_Hela1.95114674
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94957838
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92700849
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90392531
29P300_19829295_ChIP-Seq_ESCs_Human1.81868328
30TP53_22573176_ChIP-Seq_HFKS_Human1.81507066
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80567494
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.77493257
33MYC_18940864_ChIP-ChIP_HL60_Human1.73306257
34IRF1_19129219_ChIP-ChIP_H3396_Human1.72412266
35* VDR_23849224_ChIP-Seq_CD4+_Human1.71998390
36ER_23166858_ChIP-Seq_MCF-7_Human1.70079721
37TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69474782
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.67467906
39MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.66893609
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66876659
41STAT1_17558387_ChIP-Seq_HELA_Human1.65122137
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.64502020
43SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58360051
44ELK1_19687146_ChIP-ChIP_HELA_Human1.57823562
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57383007
46GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.56813619
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.56347221
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56064796
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55225161
50KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51379521
51BCAT_22108803_ChIP-Seq_LS180_Human1.49919197
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49340621
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46903228
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.46604396
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.45467809
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45391650
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41708659
58KDM2B_26808549_Chip-Seq_REH_Human1.40948805
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40121749
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.40121749
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.37405491
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.34345298
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.33863517
64STAT3_23295773_ChIP-Seq_U87_Human1.32959684
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31184369
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30824011
67CBP_20019798_ChIP-Seq_JUKART_Human1.30805696
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30805696
69FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30478987
70REST_21632747_ChIP-Seq_MESCs_Mouse1.29692675
71GATA3_21867929_ChIP-Seq_TH1_Mouse1.29295251
72RNF2_27304074_Chip-Seq_NSC_Mouse1.29177091
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28750978
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28158776
75NANOG_19829295_ChIP-Seq_ESCs_Human1.27802153
76SOX2_19829295_ChIP-Seq_ESCs_Human1.27802153
77P53_21459846_ChIP-Seq_SAOS-2_Human1.27522905
78HOXB7_26014856_ChIP-Seq_BT474_Human1.27218065
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.26805610
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26686974
81TCF4_23295773_ChIP-Seq_U87_Human1.26657010
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26252135
83NCOR_22424771_ChIP-Seq_293T_Human1.25852430
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25693114
85AR_20517297_ChIP-Seq_VCAP_Human1.24492157
86CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24018081
87AR_25329375_ChIP-Seq_VCAP_Human1.23967137
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.23278647
89SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.23125959
90CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22373934
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22324972
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21480939
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20683989
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20594010
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20360211
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20002810
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19898087
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19625821
99SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19484578
100GF1_26923725_Chip-Seq_HPCs_Mouse1.18867122
101FOXP3_21729870_ChIP-Seq_TREG_Human1.18746030
102SPI1_26923725_Chip-Seq_HPCs_Mouse1.17694953
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.17558623
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16947238
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16802993
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16427578
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15850110
108ESET_19884257_ChIP-Seq_ESCs_Mouse1.15104368
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14630074
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14630074
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.13595328
112RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13152461
113TCF4_22108803_ChIP-Seq_LS180_Human1.12503105
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12245635
115SMAD4_21799915_ChIP-Seq_A2780_Human1.10415219
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10383896
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10316146
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08981950
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.08659601
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08322242
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08030322
122* RUNX2_22187159_ChIP-Seq_PCA_Human1.07433236
123ERG_20517297_ChIP-Seq_VCAP_Human1.07018347
124POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06666269
125CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06578208
126CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06449284
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06436672
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.05196635
129MYC_27129775_Chip-Seq_CORNEA_Mouse1.04641152
130YY1_22570637_ChIP-Seq_MALME-3M_Human1.04637315
131RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04559526
132ERA_21632823_ChIP-Seq_H3396_Human1.04385969
133RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04032094
134SMAD3_21741376_ChIP-Seq_EPCs_Human1.03385175
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.02388446
136FOXH1_21741376_ChIP-Seq_EPCs_Human1.01696591
137OCT4_18555785_Chip-Seq_ESCs_Mouse0.99764424
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.99424003
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99151914
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.98902989
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98782619
142EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98527487
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.98244802
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.97117014
145LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96985507
146GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96788158
147TAF15_26573619_Chip-Seq_HEK293_Human0.96033675
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95820446
149JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95410493
150HTT_18923047_ChIP-ChIP_STHdh_Human0.95035862
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94756991
152MYC_19829295_ChIP-Seq_ESCs_Human0.94337727
153SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93765309
154NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93710020
155NANOG_20526341_ChIP-Seq_ESCs_Human0.93704884
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93695619
157PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92731622
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92423683
159GATA3_26560356_Chip-Seq_TH2_Human0.92097962
160PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91584623
161CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91542137
162CMYC_18555785_Chip-Seq_ESCs_Mouse0.91519432
163TET1_21451524_ChIP-Seq_MESCs_Mouse0.91347631
164FLI1_21867929_ChIP-Seq_CD8_Mouse0.90999130
165P53_22387025_ChIP-Seq_ESCs_Mouse0.90322480
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89430265
167KLF4_18555785_Chip-Seq_ESCs_Mouse0.88504883
168GF1B_26923725_Chip-Seq_HPCs_Mouse0.88210295
169ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88059009
170P300_18555785_Chip-Seq_ESCs_Mouse0.87740808
171SOX9_26525672_Chip-Seq_HEART_Mouse0.86475232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03169291
2MP0001929_abnormal_gametogenesis5.53828733
3MP0008877_abnormal_DNA_methylation3.92539363
4MP0002210_abnormal_sex_determination3.33054678
5MP0002161_abnormal_fertility/fecundity3.27129672
6MP0001145_abnormal_male_reproductive2.87807602
7MP0005670_abnormal_white_adipose2.65393965
8MP0002102_abnormal_ear_morphology2.59247945
9MP0001968_abnormal_touch/_nociception2.51668850
10MP0001986_abnormal_taste_sensitivity2.46781148
11MP0000653_abnormal_sex_gland2.44418478
12MP0003195_calcinosis2.42426065
13MP0006292_abnormal_olfactory_placode2.41404472
14MP0004147_increased_porphyrin_level2.38624511
15MP0000372_irregular_coat_pigmentation2.33462972
16MP0002653_abnormal_ependyma_morphology2.30747236
17MP0003787_abnormal_imprinting2.13473219
18MP0003136_yellow_coat_color2.02078990
19MP0005410_abnormal_fertilization16.5334023
20MP0002638_abnormal_pupillary_reflex1.96274221
21MP0005646_abnormal_pituitary_gland1.94687970
22MP0004142_abnormal_muscle_tone1.82137844
23MP0008872_abnormal_physiological_respon1.79522751
24MP0002160_abnormal_reproductive_system1.55076269
25MP0005174_abnormal_tail_pigmentation1.54112833
26MP0004885_abnormal_endolymph1.51129411
27MP0009745_abnormal_behavioral_response1.49549351
28MP0006276_abnormal_autonomic_nervous1.44265852
29MP0003880_abnormal_central_pattern1.42971896
30MP0002837_dystrophic_cardiac_calcinosis1.41856993
31MP0001485_abnormal_pinna_reflex1.40910766
32MP0005623_abnormal_meninges_morphology1.38687169
33MP0002163_abnormal_gland_morphology1.38209499
34MP0003011_delayed_dark_adaptation1.38129154
35MP0002938_white_spotting1.37930633
36MP0005645_abnormal_hypothalamus_physiol1.36774492
37MP0000631_abnormal_neuroendocrine_gland1.33833161
38MP0002272_abnormal_nervous_system1.32113686
39MP0002876_abnormal_thyroid_physiology1.29493510
40MP0001919_abnormal_reproductive_system1.19878777
41MP0002095_abnormal_skin_pigmentation1.19256900
42MP0001501_abnormal_sleep_pattern1.18741722
43MP0000427_abnormal_hair_cycle1.18602842
44MP0001765_abnormal_ion_homeostasis1.11714500
45MP0003121_genomic_imprinting1.11654282
46MP0005084_abnormal_gallbladder_morpholo1.11442901
47MP0001529_abnormal_vocalization1.08141505
48MP0005171_absent_coat_pigmentation1.07421799
49MP0002282_abnormal_trachea_morphology1.06506816
50MP0004145_abnormal_muscle_electrophysio1.06121850
51MP0003718_maternal_effect1.04898379
52MP0005423_abnormal_somatic_nervous1.03682479
53MP0004742_abnormal_vestibular_system1.03133989
54MP0001486_abnormal_startle_reflex1.02437225
55MP0002557_abnormal_social/conspecific_i1.01750014
56MP0001502_abnormal_circadian_rhythm1.00327262
57MP0005195_abnormal_posterior_eye1.00109655
58MP0002277_abnormal_respiratory_mucosa0.99875715
59MP0004233_abnormal_muscle_weight0.99770688
60MP0005647_abnormal_sex_gland0.98739064
61MP0008057_abnormal_DNA_replication0.98653894
62MP0003646_muscle_fatigue0.98565039
63MP0005671_abnormal_response_to0.98193746
64MP0003567_abnormal_fetal_cardiomyocyte0.97592116
65MP0002733_abnormal_thermal_nociception0.96955694
66MP0004215_abnormal_myocardial_fiber0.96876479
67MP0005379_endocrine/exocrine_gland_phen0.95162503
68MP0008789_abnormal_olfactory_epithelium0.94514656
69MP0010386_abnormal_urinary_bladder0.93410808
70MP0001970_abnormal_pain_threshold0.93073103
71MP0002572_abnormal_emotion/affect_behav0.91169583
72MP0003119_abnormal_digestive_system0.90405869
73MP0008058_abnormal_DNA_repair0.89799560
74MP0000230_abnormal_systemic_arterial0.88383343
75MP0001984_abnormal_olfaction0.87804649
76MP0002735_abnormal_chemical_nociception0.87124690
77MP0002751_abnormal_autonomic_nervous0.86878047
78MP0002234_abnormal_pharynx_morphology0.85792427
79MP0002067_abnormal_sensory_capabilities0.84219949
80MP0002064_seizures0.83578096
81MP0008775_abnormal_heart_ventricle0.81430747
82MP0002752_abnormal_somatic_nervous0.81368125
83MP0001905_abnormal_dopamine_level0.79550450
84MP0004924_abnormal_behavior0.75809582
85MP0005386_behavior/neurological_phenoty0.75809582
86MP0009046_muscle_twitch0.75297973
87MP0005389_reproductive_system_phenotype0.74811313
88MP0000647_abnormal_sebaceous_gland0.74294741
89MP0002229_neurodegeneration0.71635906
90MP0008995_early_reproductive_senescence0.66416985
91MP0010094_abnormal_chromosome_stability0.60253175
92MP0006035_abnormal_mitochondrial_morpho0.58271598
93MP0005636_abnormal_mineral_homeostasis0.58076302
94MP0001293_anophthalmia0.57596874
95MP0001324_abnormal_eye_pigmentation0.56323525
96MP0005253_abnormal_eye_physiology0.54213067
97MP0000358_abnormal_cell_content/0.52726854
98MP0006036_abnormal_mitochondrial_physio0.49593486
99MP0003115_abnormal_respiratory_system0.49286401
100MP0002269_muscular_atrophy0.49080420
101MP0005377_hearing/vestibular/ear_phenot0.47468760
102MP0003878_abnormal_ear_physiology0.47468760
103MP0005391_vision/eye_phenotype0.45683851
104MP0004264_abnormal_extraembryonic_tissu0.45066030
105MP0001348_abnormal_lacrimal_gland0.44256457
106MP0005666_abnormal_adipose_tissue0.44107798
107MP0008961_abnormal_basal_metabolism0.44050006
108MP0005257_abnormal_intraocular_pressure0.42911971
109MP0003786_premature_aging0.42591497
110MP0001849_ear_inflammation0.41076116
111MP0004036_abnormal_muscle_relaxation0.40992341
112MP0009115_abnormal_fat_cell0.40609220
113MP0003699_abnormal_female_reproductive0.40233167
114MP0001545_abnormal_hematopoietic_system0.39373836
115MP0005397_hematopoietic_system_phenotyp0.39373836
116MP0005551_abnormal_eye_electrophysiolog0.39299945
117MP0003183_abnormal_peptide_metabolism0.39124795
118MP0004133_heterotaxia0.37874344
119MP0005499_abnormal_olfactory_system0.36970510
120MP0005394_taste/olfaction_phenotype0.36970510
121MP0003329_amyloid_beta_deposits0.36393015
122MP0000678_abnormal_parathyroid_gland0.36256584
123MP0008007_abnormal_cellular_replicative0.36246631
124MP0002736_abnormal_nociception_after0.35038422
125MP0002092_abnormal_eye_morphology0.34224598
126MP0002132_abnormal_respiratory_system0.33214242
127MP0002928_abnormal_bile_duct0.32826565
128MP0004019_abnormal_vitamin_homeostasis0.32238327
129MP0003950_abnormal_plasma_membrane0.31842732
130MP0001672_abnormal_embryogenesis/_devel0.31785907
131MP0005380_embryogenesis_phenotype0.31785907
132MP0003111_abnormal_nucleus_morphology0.31313734
133MP0001730_embryonic_growth_arrest0.30799144
134MP0004043_abnormal_pH_regulation0.30274171
135MP0003890_abnormal_embryonic-extraembry0.29119536
136MP0000569_abnormal_digit_pigmentation0.28323322
137MP0000534_abnormal_ureter_morphology0.28051185
138MP0005075_abnormal_melanosome_morpholog0.27644596
139MP0003861_abnormal_nervous_system0.27120683
140MP0009278_abnormal_bone_marrow0.25599736
141MP0000313_abnormal_cell_death0.25294256
142MP0003984_embryonic_growth_retardation0.25164919
143MP0006072_abnormal_retinal_apoptosis0.24628680
144MP0004858_abnormal_nervous_system0.24595024
145MP0001119_abnormal_female_reproductive0.24312308
146MP0002084_abnormal_developmental_patter0.24277411
147MP0001764_abnormal_homeostasis0.24034215
148MP0002088_abnormal_embryonic_growth/wei0.24006895
149MP0006082_CNS_inflammation0.23791234
150MP0003633_abnormal_nervous_system0.23300073
151MP0001727_abnormal_embryo_implantation0.22884916
152MP0002932_abnormal_joint_morphology0.22501326
153MP0000049_abnormal_middle_ear0.22413689
154MP0002970_abnormal_white_adipose0.22311696
155MP0002169_no_abnormal_phenotype0.22058640
156MP0004811_abnormal_neuron_physiology0.21925658
157MP0002873_normal_phenotype0.21805379
158MP0005319_abnormal_enzyme/_coenzyme0.21761162
159MP0003942_abnormal_urinary_system0.21580066
160MP0000432_abnormal_head_morphology0.20950734
161MP0005266_abnormal_metabolism0.20253141
162MP0008875_abnormal_xenobiotic_pharmacok0.19821658
163MP0004957_abnormal_blastocyst_morpholog0.19743638
164MP0002971_abnormal_brown_adipose0.18363692
165MP0010307_abnormal_tumor_latency0.17680927

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.64152107
2Abnormal respiratory motile cilium morphology (HP:0005938)9.40888890
3Abnormal respiratory epithelium morphology (HP:0012253)9.40888890
4Abnormal ciliary motility (HP:0012262)7.90392816
5Chronic bronchitis (HP:0004469)7.77460050
6Rhinitis (HP:0012384)7.42468908
7Infertility (HP:0000789)6.67723279
8Nasal polyposis (HP:0100582)6.59528830
9Abnormality of the nasal mucosa (HP:0000433)5.42622444
10Bronchitis (HP:0012387)4.46778589
11Male infertility (HP:0003251)4.41175928
12Pancreatic cysts (HP:0001737)4.36351773
13Bronchiectasis (HP:0002110)4.23030650
14Congenital stationary night blindness (HP:0007642)4.11845829
15True hermaphroditism (HP:0010459)3.87214970
16Nephronophthisis (HP:0000090)3.74543104
17Recurrent sinusitis (HP:0011108)3.68625948
18Attenuation of retinal blood vessels (HP:0007843)3.21044261
19Abnormal spermatogenesis (HP:0008669)3.18446949
20Recurrent otitis media (HP:0000403)3.14265259
21Renal cortical cysts (HP:0000803)2.96284653
22Abnormality of alanine metabolism (HP:0010916)2.87577355
23Hyperalaninemia (HP:0003348)2.87577355
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.87577355
25Abnormality of the renal medulla (HP:0100957)2.79944542
26Type II lissencephaly (HP:0007260)2.76079686
27Aplasia/Hypoplasia of the spleen (HP:0010451)2.75385744
28Chronic hepatic failure (HP:0100626)2.71681301
29Abnormal rod and cone electroretinograms (HP:0008323)2.71471652
30Abnormality of midbrain morphology (HP:0002418)2.70696258
31Molar tooth sign on MRI (HP:0002419)2.70696258
32Asplenia (HP:0001746)2.68117822
33Abolished electroretinogram (ERG) (HP:0000550)2.66068744
34Tubulointerstitial nephritis (HP:0001970)2.59454011
35Pendular nystagmus (HP:0012043)2.49144626
36Impulsivity (HP:0100710)2.48752747
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33970769
38Male pseudohermaphroditism (HP:0000037)2.31783407
39Medial flaring of the eyebrow (HP:0010747)2.31093977
40Abnormality of the labia minora (HP:0012880)2.28334889
41Tubular atrophy (HP:0000092)2.27606227
42Dyschromatopsia (HP:0007641)2.27472684
43Recurrent bronchitis (HP:0002837)2.26324282
44Abnormality of the renal collecting system (HP:0004742)2.24458549
45Acute necrotizing encephalopathy (HP:0006965)2.22693514
46Concave nail (HP:0001598)2.21782333
47Nephrogenic diabetes insipidus (HP:0009806)2.21667293
48Sclerocornea (HP:0000647)2.20507677
49Hyperventilation (HP:0002883)2.19090894
503-Methylglutaconic aciduria (HP:0003535)2.16482260
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.16050961
52Abnormality of the lower motor neuron (HP:0002366)2.14754821
53Gonadotropin excess (HP:0000837)2.14023859
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11638978
55Tubulointerstitial abnormality (HP:0001969)2.11205199
56Lissencephaly (HP:0001339)2.10348472
57Increased CSF lactate (HP:0002490)2.09992245
58Bony spicule pigmentary retinopathy (HP:0007737)2.08437908
59Gaze-evoked nystagmus (HP:0000640)2.08345751
60Anencephaly (HP:0002323)2.06376295
61Mitochondrial inheritance (HP:0001427)2.05853048
62Patellar aplasia (HP:0006443)2.05490749
63Congenital, generalized hypertrichosis (HP:0004540)2.05210141
64Cerebellar dysplasia (HP:0007033)2.04851896
65Optic disc pallor (HP:0000543)2.04757500
66Abnormality of the ileum (HP:0001549)2.04067659
67Acute encephalopathy (HP:0006846)2.01993181
68Abnormality of DNA repair (HP:0003254)2.00609904
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.00228931
70Meckel diverticulum (HP:0002245)2.00117387
71Dynein arm defect of respiratory motile cilia (HP:0012255)13.9189420
72Absent/shortened dynein arms (HP:0200106)13.9189420
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2461090
74Duplicated collecting system (HP:0000081)1.99740742
75Abnormality of the pons (HP:0007361)1.98533946
76Inability to walk (HP:0002540)1.96895869
77Aplasia/Hypoplasia of the patella (HP:0006498)1.95670576
78Genital tract atresia (HP:0001827)1.95657519
79Polyuria (HP:0000103)1.94345787
80Genetic anticipation (HP:0003743)1.93160550
81Cholecystitis (HP:0001082)1.93101352
82Abnormal gallbladder physiology (HP:0012438)1.93101352
83Large for gestational age (HP:0001520)1.91791037
84Vaginal atresia (HP:0000148)1.90982548
85Optic nerve hypoplasia (HP:0000609)1.90327317
86Progressive inability to walk (HP:0002505)1.89425438
87Progressive macrocephaly (HP:0004481)1.89276139
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.88664307
89Azoospermia (HP:0000027)1.88124286
90Spastic tetraparesis (HP:0001285)1.87586615
91Hypoplasia of the pons (HP:0012110)1.86547237
92Methylmalonic acidemia (HP:0002912)1.86268806
93Keratoconus (HP:0000563)1.85663704
94Increased corneal curvature (HP:0100692)1.85663704
95Rib fusion (HP:0000902)1.83594842
96Abnormal mitochondria in muscle tissue (HP:0008316)1.83549746
97Pachygyria (HP:0001302)1.83473883
98Stomach cancer (HP:0012126)1.82630677
99Intestinal atresia (HP:0011100)1.79216849
100Decreased circulating renin level (HP:0003351)1.78581332
101Absent thumb (HP:0009777)1.77926233
102Oligohydramnios (HP:0001562)1.77614163
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.77313186
104Hypoplasia of the fovea (HP:0007750)1.77313186
105Methylmalonic aciduria (HP:0012120)1.77188613
106Furrowed tongue (HP:0000221)1.76794139
107Retinal dysplasia (HP:0007973)1.75870926
108Amyotrophic lateral sclerosis (HP:0007354)1.75725357
109Postaxial foot polydactyly (HP:0001830)1.75073108
110Astigmatism (HP:0000483)1.74736823
111Hypothermia (HP:0002045)1.74523304
112Poor coordination (HP:0002370)1.73723056
113Progressive cerebellar ataxia (HP:0002073)1.72571871
114Abnormal number of erythroid precursors (HP:0012131)1.71642547
115Stomatitis (HP:0010280)1.70755989
116Decreased central vision (HP:0007663)1.67795375
117Choroideremia (HP:0001139)1.62664220
118Tubulointerstitial fibrosis (HP:0005576)1.61166665
119Abnormality of permanent molar morphology (HP:0011071)1.58156961
120Abnormality of the dental root (HP:0006486)1.58156961
121Taurodontia (HP:0000679)1.58156961
122Congenital hepatic fibrosis (HP:0002612)1.57976243
123Stage 5 chronic kidney disease (HP:0003774)1.57102220
124Abnormal biliary tract physiology (HP:0012439)1.53959350
125Bile duct proliferation (HP:0001408)1.53959350
126Heterotopia (HP:0002282)1.52895345
127Facial cleft (HP:0002006)1.52268619
128Oculomotor apraxia (HP:0000657)1.50233149
129Abnormality of renal excretion (HP:0011036)1.49809139
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.46998433
131Abnormal drinking behavior (HP:0030082)1.46173626
132Polydipsia (HP:0001959)1.46173626
133Abnormality of the dental pulp (HP:0006479)1.45923569
134Fibular hypoplasia (HP:0003038)1.45369904
135Abnormality of molar (HP:0011077)1.44873295
136Abnormality of molar morphology (HP:0011070)1.44873295
137Hemorrhage of the eye (HP:0011885)1.43482285
138Abnormality of the renal cortex (HP:0011035)1.42833834
139Postaxial hand polydactyly (HP:0001162)1.42784628
140Abnormality of dentin (HP:0010299)1.41454449
141Sensory axonal neuropathy (HP:0003390)1.40969282
142Aplasia/Hypoplasia of the lens (HP:0008063)1.38793204
143Short ribs (HP:0000773)1.36927600
144Asymmetric septal hypertrophy (HP:0001670)1.35504484
145Absent frontal sinuses (HP:0002688)1.33687673
146Supernumerary spleens (HP:0009799)1.29172612
147Gait imbalance (HP:0002141)1.28931119
148Congenital primary aphakia (HP:0007707)1.28589969
149Double outlet right ventricle (HP:0001719)1.27879716
150Congenital malformation of the right heart (HP:0011723)1.27879716
151Cystic liver disease (HP:0006706)1.25055375
152Short humerus (HP:0005792)1.22777168
153Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.22637253
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.21168390
155Bell-shaped thorax (HP:0001591)1.20584379
156Neurofibrillary tangles (HP:0002185)1.19694458
157Hemiparesis (HP:0001269)1.19686896
158Impaired proprioception (HP:0010831)1.19499453
159Renal dysplasia (HP:0000110)1.19401516
160Nephroblastoma (Wilms tumor) (HP:0002667)1.18800433
161Chronic sinusitis (HP:0011109)1.17358057
162Constricted visual fields (HP:0001133)1.15461112
163Abnormality of the phalanges of the hallux (HP:0010057)1.14162551
164Neoplasm of the heart (HP:0100544)1.13436278
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.13377623
166Absent epiphyses (HP:0010577)1.13377623
167Vascular calcification (HP:0004934)1.12925483
168Abnormal urine output (HP:0012590)1.12234042
169Bundle branch block (HP:0011710)1.11011638
170Deformed sella turcica (HP:0002681)1.10777913
171Embryonal renal neoplasm (HP:0011794)1.09600061
172Short thorax (HP:0010306)1.09136939
173Myoglobinuria (HP:0002913)1.08704088
174Exercise-induced myalgia (HP:0003738)1.08225388
175Bifid tongue (HP:0010297)1.07542474
176Aplasia/hypoplasia of the humerus (HP:0006507)1.07066625
177Exercise-induced muscle cramps (HP:0003710)1.06504124
178Pancreatic fibrosis (HP:0100732)1.05979768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.76292006
2PDK48.76292006
3PDK25.70562454
4TESK15.24103346
5FRK4.26445849
6PRKD34.18788455
7ICK3.74709322
8ACVR1B3.63397757
9MAP4K22.61568848
10INSRR2.48394441
11TLK12.37388129
12BMPR1B2.33945232
13ZAK2.28111523
14TXK2.15774944
15NUAK12.13652768
16WNK32.12896069
17TAOK32.09903867
18PTK2B1.97625210
19MAPK131.97583626
20WNK41.87194399
21STK391.84113528
22MAP3K41.65586185
23BCKDK1.60670320
24STK381.57801622
25NEK21.52645006
26PNCK1.49557956
27CDK121.43964198
28TNIK1.42301612
29OXSR11.41421233
30DYRK21.38201086
31DYRK1B1.36234686
32TYRO31.20922123
33PDK11.19548870
34TRIM281.19368768
35CASK1.18745896
36WNK11.11388847
37GRK51.08472321
38PAK31.06802620
39DAPK21.06672940
40VRK11.05073654
41TAF11.05047273
42MKNK20.98690137
43MAP2K70.97805678
44STK160.97560435
45BCR0.96566115
46DYRK30.95483823
47CAMKK20.91999341
48TTK0.87168502
49VRK20.84171313
50GRK60.81331043
51TGFBR10.79445472
52CSNK1G20.77871887
53IRAK40.77641558
54AKT30.77474781
55MST40.75793131
56TEC0.73551768
57MAP2K60.72725759
58KIT0.72716848
59EPHA40.71515038
60IRAK10.71345360
61RPS6KA50.69351105
62TNK20.69137388
63PLK20.67571166
64IKBKB0.67160872
65GRK10.66868938
66ADRBK20.66589388
67MAP3K100.64510029
68CHEK20.63879123
69PRKCE0.62777469
70MAPK150.62003775
71PDPK10.61891734
72PASK0.61231238
73TESK20.60848959
74RIPK40.60503090
75MKNK10.60068977
76CDK190.59729993
77CSNK1G10.59575485
78PINK10.57089933
79EIF2AK30.55858009
80CSF1R0.55606873
81STK30.55237235
82CCNB10.54696996
83SYK0.53624559
84CSNK1G30.52989527
85ITK0.52354217
86PHKG10.51794494
87PHKG20.51794494
88MARK10.50698361
89TIE10.50559223
90PLK30.50068325
91ERBB30.47543052
92NTRK30.45559124
93CSNK1A1L0.44073217
94LMTK20.43833034
95CHEK10.43450214
96MARK20.41729462
97SGK20.41538790
98CAMK2A0.41035157
99RPS6KA60.40341456
100SRPK10.39763494
101PRKG20.39650001
102PRKCI0.37960370
103STK100.37940014
104PRKCG0.37937704
105IKBKE0.37422343
106PAK10.37102033
107ERN10.36801570
108NLK0.36094857
109NTRK20.35761877
110OBSCN0.35687292
111EPHA30.35652134
112CHUK0.34799270
113EEF2K0.34172481
114MAP2K20.34143576
115IRAK20.34018427
116STK38L0.33789997
117SIK20.33359253
118PAK40.29137502
119MUSK0.29123915
120ATM0.28487668
121CAMK1G0.27411366
122PLK10.26633165
123PAK20.26444028
124MTOR0.24890581
125GRK70.19592069
126CDK150.19083386
127ATR0.19046747
128TGFBR20.17573349
129PRKAA10.17184508
130WEE10.16411950
131CDK180.16058789
132CDK11A0.14806135
133MAPKAPK50.14599277
134CAMKK10.14542951
135PRKCZ0.12604814
136MAPK70.12512845
137PLK40.11588050
138PRKACG0.10953307
139CDC70.10923099
140CDK140.10811738
141PRKCQ0.10574962
142PRKCD0.09777697
143RPS6KB10.08087160
144GSK3B0.06043851
145PRKG10.05879784
146CDK20.05559776
147ADRBK10.04673495
148CSNK2A10.04554676
149BRSK20.04365015
150CDK10.03808151
151PKN10.03764621
152NEK60.03724790
153CSNK1D0.03637038
154RPS6KA10.02294425
155AURKA0.02228943
156MOS0.02128788
157IGF1R0.01901536
158PRKACB0.01759609
159MARK30.01375788
160CSK0.01242170
161MAPK80.01012686
162PRKACA0.00954955
163RPS6KA30.00185071
164PAK6-0.0191509
165PIM1-0.0181418
166MATK-0.0165525
167PRKCB-0.0059887
168PRKCA-0.0042611
169BRAF-0.0005040

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.76735155
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.54542566
3Fatty acid biosynthesis_Homo sapiens_hsa000614.06395179
4Pyruvate metabolism_Homo sapiens_hsa006203.59576183
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.12261492
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.09207828
7Linoleic acid metabolism_Homo sapiens_hsa005913.07858289
8Phototransduction_Homo sapiens_hsa047442.93100826
9Propanoate metabolism_Homo sapiens_hsa006402.81270453
10Glucagon signaling pathway_Homo sapiens_hsa049222.53925076
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52072828
12Homologous recombination_Homo sapiens_hsa034402.46545457
13Oxidative phosphorylation_Homo sapiens_hsa001902.45183154
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40212151
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.31583353
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.24783636
17Protein export_Homo sapiens_hsa030602.22846348
18Nitrogen metabolism_Homo sapiens_hsa009102.21050972
19Basal transcription factors_Homo sapiens_hsa030222.14937354
20Fructose and mannose metabolism_Homo sapiens_hsa000512.05584235
21Parkinsons disease_Homo sapiens_hsa050122.03766394
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01205920
23Butanoate metabolism_Homo sapiens_hsa006502.00257836
24RNA polymerase_Homo sapiens_hsa030202.00034763
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94323008
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91895434
27Pentose phosphate pathway_Homo sapiens_hsa000301.89220642
28Glycerolipid metabolism_Homo sapiens_hsa005611.87128169
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85427782
30Selenocompound metabolism_Homo sapiens_hsa004501.84497986
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83015076
32PPAR signaling pathway_Homo sapiens_hsa033201.76609861
33Nicotine addiction_Homo sapiens_hsa050331.69080389
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65569558
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.60436480
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58299654
37Oocyte meiosis_Homo sapiens_hsa041141.57812068
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50040328
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.49802919
40RNA degradation_Homo sapiens_hsa030181.49300485
41Tryptophan metabolism_Homo sapiens_hsa003801.47946387
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47209820
43Ether lipid metabolism_Homo sapiens_hsa005651.44900473
44Regulation of autophagy_Homo sapiens_hsa041401.44110684
45Ribosome_Homo sapiens_hsa030101.42315440
46Caffeine metabolism_Homo sapiens_hsa002321.40109880
47Carbon metabolism_Homo sapiens_hsa012001.40008730
48Amphetamine addiction_Homo sapiens_hsa050311.37012573
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.34570664
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.33480135
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.33361136
52One carbon pool by folate_Homo sapiens_hsa006701.32583639
53Mineral absorption_Homo sapiens_hsa049781.31797974
54Fanconi anemia pathway_Homo sapiens_hsa034601.28120128
55Cardiac muscle contraction_Homo sapiens_hsa042601.25372522
56Olfactory transduction_Homo sapiens_hsa047401.22081025
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22024131
58Arachidonic acid metabolism_Homo sapiens_hsa005901.21235648
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20910294
60Primary immunodeficiency_Homo sapiens_hsa053401.15324954
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14158008
62Non-homologous end-joining_Homo sapiens_hsa034501.13685391
63Alzheimers disease_Homo sapiens_hsa050101.13536148
64Fat digestion and absorption_Homo sapiens_hsa049751.12957141
65Renin secretion_Homo sapiens_hsa049241.12753084
66Fatty acid degradation_Homo sapiens_hsa000711.10453806
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08346819
68Fatty acid metabolism_Homo sapiens_hsa012121.07711527
69Morphine addiction_Homo sapiens_hsa050321.07538923
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06431473
71Peroxisome_Homo sapiens_hsa041461.06150312
72Dorso-ventral axis formation_Homo sapiens_hsa043201.05751374
73Chemical carcinogenesis_Homo sapiens_hsa052041.04537411
74Sulfur relay system_Homo sapiens_hsa041221.03700866
75Steroid biosynthesis_Homo sapiens_hsa001001.00266327
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97428773
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96538666
78mRNA surveillance pathway_Homo sapiens_hsa030150.95768386
79Proteasome_Homo sapiens_hsa030500.95718012
80Purine metabolism_Homo sapiens_hsa002300.94444652
81Biosynthesis of amino acids_Homo sapiens_hsa012300.93775697
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92040171
83Collecting duct acid secretion_Homo sapiens_hsa049660.91209634
84Glutathione metabolism_Homo sapiens_hsa004800.88874774
85Base excision repair_Homo sapiens_hsa034100.84924927
86RNA transport_Homo sapiens_hsa030130.82785781
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81111362
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.80711675
89Antigen processing and presentation_Homo sapiens_hsa046120.77788617
90Huntingtons disease_Homo sapiens_hsa050160.76334942
91Hedgehog signaling pathway_Homo sapiens_hsa043400.75805865
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75758559
93Serotonergic synapse_Homo sapiens_hsa047260.75614994
94Long-term potentiation_Homo sapiens_hsa047200.73459771
95Nucleotide excision repair_Homo sapiens_hsa034200.69771047
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69516589
97Asthma_Homo sapiens_hsa053100.66844038
98GABAergic synapse_Homo sapiens_hsa047270.65431101
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65208936
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.63936299
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.63452369
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63405112
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63250961
104Bile secretion_Homo sapiens_hsa049760.62618562
105Insulin secretion_Homo sapiens_hsa049110.60296305
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59461890
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57744208
108Mismatch repair_Homo sapiens_hsa034300.56617968
109Calcium signaling pathway_Homo sapiens_hsa040200.56615912
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56512833
111Fatty acid elongation_Homo sapiens_hsa000620.53590744
112Inositol phosphate metabolism_Homo sapiens_hsa005620.53420186
113Thyroid hormone synthesis_Homo sapiens_hsa049180.53359936
114VEGF signaling pathway_Homo sapiens_hsa043700.52616283
115Allograft rejection_Homo sapiens_hsa053300.50317236
116Circadian rhythm_Homo sapiens_hsa047100.50292941
117Estrogen signaling pathway_Homo sapiens_hsa049150.49126523
118Graft-versus-host disease_Homo sapiens_hsa053320.46979308
119beta-Alanine metabolism_Homo sapiens_hsa004100.46276868
120Type I diabetes mellitus_Homo sapiens_hsa049400.46099693
121Protein digestion and absorption_Homo sapiens_hsa049740.44299132
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43729439
123Salivary secretion_Homo sapiens_hsa049700.43114795
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42634042
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41912604
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.41488918
127Metabolic pathways_Homo sapiens_hsa011000.41429290
128Renin-angiotensin system_Homo sapiens_hsa046140.41032502
129Autoimmune thyroid disease_Homo sapiens_hsa053200.40537459
130Legionellosis_Homo sapiens_hsa051340.40014383
131AMPK signaling pathway_Homo sapiens_hsa041520.39470656
132Taste transduction_Homo sapiens_hsa047420.38353796
133p53 signaling pathway_Homo sapiens_hsa041150.37677020
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37506042
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36989465
136Folate biosynthesis_Homo sapiens_hsa007900.36264603
137ABC transporters_Homo sapiens_hsa020100.35911067
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35838348
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35611171
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35262207
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33090592
142Pancreatic secretion_Homo sapiens_hsa049720.32165401
143Synaptic vesicle cycle_Homo sapiens_hsa047210.31002704
144Systemic lupus erythematosus_Homo sapiens_hsa053220.30787242
145cAMP signaling pathway_Homo sapiens_hsa040240.29942631
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29502833
147Sulfur metabolism_Homo sapiens_hsa009200.28891891
148Endocytosis_Homo sapiens_hsa041440.28587774
149Gastric acid secretion_Homo sapiens_hsa049710.22634042
150Pyrimidine metabolism_Homo sapiens_hsa002400.21261680
151Wnt signaling pathway_Homo sapiens_hsa043100.20791452
152B cell receptor signaling pathway_Homo sapiens_hsa046620.19839032
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19786166
154Glutamatergic synapse_Homo sapiens_hsa047240.17389973
155Retinol metabolism_Homo sapiens_hsa008300.13599080
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13566852
157Circadian entrainment_Homo sapiens_hsa047130.13265779
158Alcoholism_Homo sapiens_hsa050340.12441851
159Galactose metabolism_Homo sapiens_hsa000520.11298837
160Steroid hormone biosynthesis_Homo sapiens_hsa001400.10778871
161Ovarian steroidogenesis_Homo sapiens_hsa049130.10418752
162Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.09214955
163Basal cell carcinoma_Homo sapiens_hsa052170.08716235

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