FAM122A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.23340329
2signal peptide processing (GO:0006465)5.91880622
3glycine transport (GO:0015816)5.25185508
4regulation of female gonad development (GO:2000194)5.19193587
5regulation of DNA methylation (GO:0044030)5.10998083
6proline biosynthetic process (GO:0006561)5.10387260
7COPI coating of Golgi vesicle (GO:0048205)4.66263005
8Golgi transport vesicle coating (GO:0048200)4.66263005
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.63081479
10regulation of early endosome to late endosome transport (GO:2000641)4.34694004
11cellular response to zinc ion (GO:0071294)4.33837644
12protein retention in ER lumen (GO:0006621)4.31804593
13oocyte development (GO:0048599)4.04978155
14COPII vesicle coating (GO:0048208)4.04407661
15regulation of acrosome reaction (GO:0060046)3.97981812
16positive regulation of humoral immune response (GO:0002922)3.95649485
17protein maturation by protein folding (GO:0022417)3.89522886
18definitive hemopoiesis (GO:0060216)3.82917264
19positive regulation of granulocyte differentiation (GO:0030854)3.82840022
20succinate metabolic process (GO:0006105)3.76638676
21heme biosynthetic process (GO:0006783)3.75732072
22detection of other organism (GO:0098543)3.73876287
23respiratory chain complex IV assembly (GO:0008535)3.72283732
24regulation of steroid hormone biosynthetic process (GO:0090030)3.72142537
25negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.69675543
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.66930738
27negative regulation of cell killing (GO:0031342)3.66930738
28regulation of vitamin D biosynthetic process (GO:0060556)3.57672363
29relaxation of smooth muscle (GO:0044557)3.54936620
30phosphatidylinositol dephosphorylation (GO:0046856)3.53735260
31endocrine pancreas development (GO:0031018)3.45552267
32phospholipid dephosphorylation (GO:0046839)3.41792361
33neutrophil activation involved in immune response (GO:0002283)3.38315286
34detection of bacterium (GO:0016045)3.38261976
35meiotic cell cycle (GO:0051321)3.34537904
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.33977593
37negative regulation of execution phase of apoptosis (GO:1900118)3.21602902
38cytochrome complex assembly (GO:0017004)3.18559234
39pteridine-containing compound biosynthetic process (GO:0042559)3.18454930
40ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.15707662
41regulation of steroid hormone secretion (GO:2000831)3.15458744
42interkinetic nuclear migration (GO:0022027)3.15000452
43transcription from mitochondrial promoter (GO:0006390)3.14924265
44negative regulation of reproductive process (GO:2000242)3.14443058
45glandular epithelial cell development (GO:0002068)3.13371066
46sequestering of metal ion (GO:0051238)3.12184469
47cellular response to interferon-beta (GO:0035458)3.11489680
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10230533
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10230533
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.10230533
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08480721
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08480721
53proline metabolic process (GO:0006560)3.08200671
54negative regulation of type 2 immune response (GO:0002829)3.08164450
55defense response to protozoan (GO:0042832)3.07869822
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.07506290
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.07313567
58negative regulation of erythrocyte differentiation (GO:0045647)3.03274818
59retinal cone cell development (GO:0046549)3.03196436
60regulation of vitamin metabolic process (GO:0030656)3.01873649
61regulation of cell maturation (GO:1903429)3.01411927
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99816690
63regulation of meiosis I (GO:0060631)2.98063041
64protein targeting to ER (GO:0045047)2.97131715
65cotranslational protein targeting to membrane (GO:0006613)2.95863237
66histone H3-K9 demethylation (GO:0033169)2.95669855
67negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.95649818
68negative regulation of cardiac muscle hypertrophy (GO:0010614)2.95317551
69positive regulation of histone H3-K4 methylation (GO:0051571)2.95227181
70negative regulation of hormone biosynthetic process (GO:0032353)2.95107755
71folic acid-containing compound biosynthetic process (GO:0009396)2.94009512
72positive regulation of lamellipodium assembly (GO:0010592)2.93976001
73positive regulation of protein homooligomerization (GO:0032464)2.91905693
74piRNA metabolic process (GO:0034587)2.89631697
75antigen processing and presentation of endogenous antigen (GO:0019883)2.89211052
76response to interferon-beta (GO:0035456)2.86637589
77cellular extravasation (GO:0045123)2.85780672
78establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82019457
79inositol phosphate dephosphorylation (GO:0046855)2.81963140
80phosphorylated carbohydrate dephosphorylation (GO:0046838)2.81963140
81protein localization to endoplasmic reticulum (GO:0070972)2.81811001
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81424982
83positive regulation by organism of defense response of other organism involved in symbiotic interact2.81424982
84modulation by symbiont of host immune response (GO:0052553)2.81424982
85positive regulation by symbiont of host defense response (GO:0052509)2.81424982
86modulation by symbiont of host defense response (GO:0052031)2.81424982
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81424982
88response to peptidoglycan (GO:0032494)2.80967740
89respiratory burst (GO:0045730)2.80670743
90response to protozoan (GO:0001562)2.80362733
91detection of external biotic stimulus (GO:0098581)2.79636290
92oxidative demethylation (GO:0070989)2.78959933
93negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.78750759
94GDP-mannose metabolic process (GO:0019673)2.77841346
95cellular response to arsenic-containing substance (GO:0071243)2.77602242
96regulation of integrin activation (GO:0033623)2.77569838
97replication fork processing (GO:0031297)2.77243058
98negative regulation of protein localization to plasma membrane (GO:1903077)2.76581613
99negative regulation of hormone metabolic process (GO:0032351)2.74818787
100macrophage activation involved in immune response (GO:0002281)2.74732766
101heme metabolic process (GO:0042168)2.73643004
102base-excision repair, AP site formation (GO:0006285)2.72071621
103positive regulation of T cell apoptotic process (GO:0070234)2.71714897
104positive regulation of lamellipodium organization (GO:1902745)2.71290616
105potassium ion export (GO:0071435)2.68812452
106pseudouridine synthesis (GO:0001522)2.68048903
107formation of translation preinitiation complex (GO:0001731)2.67492897
108detection of molecule of bacterial origin (GO:0032490)2.67484179
109lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66912723
110positive regulation of gamma-delta T cell activation (GO:0046645)2.66337949
111negative regulation of interleukin-12 production (GO:0032695)2.66168738
112ubiquinone biosynthetic process (GO:0006744)2.66014038
113quinone biosynthetic process (GO:1901663)2.66014038
114negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64694878
115negative regulation of interleukin-17 production (GO:0032700)2.64420795
116positive regulation of Rap GTPase activity (GO:0032854)2.64118476
117negative regulation of lymphocyte mediated immunity (GO:0002707)2.64023569
118valine metabolic process (GO:0006573)2.63966146
119regulation of gamma-delta T cell differentiation (GO:0045586)2.63591069
120regulation of interleukin-12 biosynthetic process (GO:0045075)2.63529178
121inositol phosphate catabolic process (GO:0071545)2.63323139
122production of molecular mediator involved in inflammatory response (GO:0002532)2.63281039
123regulation of histone H3-K9 methylation (GO:0051570)2.63113863
124positive regulation of actin filament depolymerization (GO:0030836)2.62836347
125ribosomal small subunit assembly (GO:0000028)2.62617527
126negative regulation of JAK-STAT cascade (GO:0046426)2.61705799
127cell volume homeostasis (GO:0006884)2.59099574
128telomere maintenance via semi-conservative replication (GO:0032201)2.58094643
129negative regulation of glial cell proliferation (GO:0060253)2.57944236
130porphyrin-containing compound biosynthetic process (GO:0006779)2.57520147
131lipopolysaccharide metabolic process (GO:0008653)2.57058785
132synapsis (GO:0007129)2.57017456
133response to host immune response (GO:0052572)2.57005425
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57005425
135deoxyribonucleotide catabolic process (GO:0009264)2.56244652
136regulation of histone phosphorylation (GO:0033127)2.55661752
137negative regulation of cAMP-mediated signaling (GO:0043951)2.54859107
138negative regulation of muscle hypertrophy (GO:0014741)2.54813685
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.54343517
140regulation of cAMP-dependent protein kinase activity (GO:2000479)2.54117590
141N-acetylneuraminate metabolic process (GO:0006054)2.53978340
142negative regulation of smooth muscle contraction (GO:0045986)2.53907501
143lipopolysaccharide biosynthetic process (GO:0009103)2.53828390
144germinal center formation (GO:0002467)2.53540972
145positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52970310
146negative regulation of T cell mediated immunity (GO:0002710)2.52262405
147positive regulation of B cell differentiation (GO:0045579)2.51663847
148erythrocyte maturation (GO:0043249)2.51334755
149anterograde synaptic vesicle transport (GO:0048490)2.51107952
150immunoglobulin mediated immune response (GO:0016064)2.48799222
151erythrocyte development (GO:0048821)2.48626130
152mitochondrial DNA metabolic process (GO:0032042)2.48578572
153positive regulation of nuclease activity (GO:0032075)2.46397300
154labyrinthine layer development (GO:0060711)2.45260166
155activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.45023187
156female gamete generation (GO:0007292)2.44418947
157regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.43945687
158gamma-aminobutyric acid transport (GO:0015812)2.43325055
159cAMP catabolic process (GO:0006198)2.42480537
160regulation of granulocyte differentiation (GO:0030852)2.40520091
161NIK/NF-kappaB signaling (GO:0038061)2.39965667
162protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.39779689
163tetrapyrrole biosynthetic process (GO:0033014)2.39653641
164multicellular organism reproduction (GO:0032504)2.39302504
165pyrimidine nucleotide catabolic process (GO:0006244)2.39275334
166maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39268990
167interleukin-6-mediated signaling pathway (GO:0070102)2.38892767
168negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.38744363
169myeloid dendritic cell differentiation (GO:0043011)2.37703230
170glandular epithelial cell differentiation (GO:0002067)2.36813000
171negative regulation of cell cycle arrest (GO:0071157)2.36701589
172negative regulation of T-helper cell differentiation (GO:0045623)2.36540926
173negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.36540926
174Arp2/3 complex-mediated actin nucleation (GO:0034314)2.34674441
175negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.34579428
176regulation of type B pancreatic cell apoptotic process (GO:2000674)2.34457727
177deoxyribose phosphate catabolic process (GO:0046386)2.34060062
178antigen processing and presentation via MHC class Ib (GO:0002475)2.33957077
179regulation of erythrocyte differentiation (GO:0045646)2.33307618
180male meiosis I (GO:0007141)2.32799091
181negative regulation of leukocyte mediated immunity (GO:0002704)2.31814843
182regulation of B cell receptor signaling pathway (GO:0050855)2.31619604
183protein targeting to Golgi (GO:0000042)2.31563574
184cellular zinc ion homeostasis (GO:0006882)2.30771366
185response to progesterone (GO:0032570)2.30340519
186natural killer cell activation involved in immune response (GO:0002323)2.29470082
187regulation of gamma-delta T cell activation (GO:0046643)2.29428212
188neutrophil activation (GO:0042119)2.28908273
189protein N-linked glycosylation via asparagine (GO:0018279)2.28888840
190positive regulation of lymphocyte apoptotic process (GO:0070230)2.28260413
191regulation of nuclease activity (GO:0032069)2.27974907
192ubiquinone metabolic process (GO:0006743)2.27046474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.88874703
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.58181848
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.15603018
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14042628
5EZH2_22144423_ChIP-Seq_EOC_Human2.96558948
6MYC_22102868_ChIP-Seq_BL_Human2.94265564
7VDR_21846776_ChIP-Seq_THP-1_Human2.94003302
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.89694971
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.67790252
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.49302964
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47195411
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.38106268
13HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.30924761
14E2F7_22180533_ChIP-Seq_HELA_Human2.28377794
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24110652
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.21422057
17* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.16495861
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10273687
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05673349
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01894096
21VDR_24763502_ChIP-Seq_THP-1_Human2.00531366
22SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.97277780
23MAF_26560356_Chip-Seq_TH1_Human1.95296022
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94942764
25* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.94617505
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.94301495
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93751864
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93751864
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93751864
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92974293
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92110894
32* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91247231
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.89585866
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86287169
35SPI1_23547873_ChIP-Seq_NB4_Human1.84189533
36RUNX_20019798_ChIP-Seq_JUKART_Human1.83927923
37SCL_19346495_ChIP-Seq_HPC-7_Human1.81738719
38* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.81482924
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79108472
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.76279504
41* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75656384
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.71394291
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71022112
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69655242
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69483038
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.68808147
47GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.68580305
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67515450
49TCF7_22412390_ChIP-Seq_EML_Mouse1.66467167
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64432328
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64016433
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61669753
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61426513
54UTX_26944678_Chip-Seq_JUKART_Human1.60355591
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.60349174
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58401728
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58018222
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57727555
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57587418
60GABP_19822575_ChIP-Seq_HepG2_Human1.54828643
61LXR_22292898_ChIP-Seq_THP-1_Human1.54800888
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54786961
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53690076
64MYB_26560356_Chip-Seq_TH2_Human1.53038356
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51906595
66NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51905619
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49561150
68SALL4_22934838_ChIP-ChIP_CD34+_Human1.49037278
69DCP1A_22483619_ChIP-Seq_HELA_Human1.48883143
70* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48286580
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.45379756
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45108089
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45006160
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.44707956
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44586404
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44315230
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42907895
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42856049
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40710144
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40425475
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40237832
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.39130736
83KDM2B_26808549_Chip-Seq_DND41_Human1.38464969
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38064760
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36515067
86* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35684102
87* VDR_23849224_ChIP-Seq_CD4+_Human1.35468150
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.35054003
89MYB_26560356_Chip-Seq_TH1_Human1.35043552
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34141394
91BP1_19119308_ChIP-ChIP_Hs578T_Human1.31657481
92VDR_24787735_ChIP-Seq_THP-1_Human1.31400662
93MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30608169
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30483163
95* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29128613
96MAF_26560356_Chip-Seq_TH2_Human1.28069935
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28010598
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27357099
99SPI1_23127762_ChIP-Seq_K562_Human1.25512545
100STAT1_20625510_ChIP-Seq_HELA_Human1.25092793
101HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24214470
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23841069
103ETS1_22383799_ChIP-Seq_G1ME_Mouse1.22961480
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22086428
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21985066
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21264693
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20981677
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20828908
109TFEB_21752829_ChIP-Seq_HELA_Human1.20589257
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.20151086
111SMRT_27268052_Chip-Seq_Bcells_Human1.20095168
112* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20048335
113GATA3_27048872_Chip-Seq_THYMUS_Human1.19975137
114GATA1_19941827_ChIP-Seq_MEL_Mouse1.19200343
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18317307
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18021958
117CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17036580
118FOXP3_21729870_ChIP-Seq_TREG_Human1.14321023
119PU_27001747_Chip-Seq_BMDM_Mouse1.13938262
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13598455
121* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13490775
122GATA1_22025678_ChIP-Seq_K562_Human1.13368099
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13220586
124IRF8_27001747_Chip-Seq_BMDM_Mouse1.09280477
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08732242
126GATA2_19941826_ChIP-Seq_K562_Human1.07470101
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06483066
128TET1_21451524_ChIP-Seq_MESCs_Mouse1.06122700
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05979676
130RACK7_27058665_Chip-Seq_MCF-7_Human1.05936110
131GATA1_19941826_ChIP-Seq_K562_Human1.05197032
132KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04684615
133* GATA3_26560356_Chip-Seq_TH1_Human1.04093610
134NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02724335
135REST_19997604_ChIP-ChIP_NEURONS_Mouse1.02706118
136CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02141625
137ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02053366
138CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02004204
139EZH2_27294783_Chip-Seq_NPCs_Mouse1.01811903
140XRN2_22483619_ChIP-Seq_HELA_Human1.00771933
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00362540
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00006096
143EP300_21415370_ChIP-Seq_HL-1_Mouse0.98679583
144PRDM14_20953172_ChIP-Seq_ESCs_Human0.98163467
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.98116047
146CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97188157
147CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96868658
148TAF15_26573619_Chip-Seq_HEK293_Human0.93905957
149* SMAD4_21799915_ChIP-Seq_A2780_Human0.93771890
150EWS_26573619_Chip-Seq_HEK293_Human0.90585089
151* TAL1_26923725_Chip-Seq_HPCs_Mouse0.90500147
152GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88974463
153IRF1_19129219_ChIP-ChIP_H3396_Human0.88847785
154FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88611661
155GATA3_26560356_Chip-Seq_TH2_Human0.86510679
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85029726
157* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82790618
158CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81799451
159HTT_18923047_ChIP-ChIP_STHdh_Human0.80975044
160* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80370621
161FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79739678
162NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78738022
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78291129
164CDX2_22108803_ChIP-Seq_LS180_Human0.77561772
165FOXO3_23340844_ChIP-Seq_DLD1_Human0.77441296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.41285959
2MP0002139_abnormal_hepatobiliary_system3.39905559
3MP0010234_abnormal_vibrissa_follicle3.38893498
4MP0005058_abnormal_lysosome_morphology2.93571510
5MP0003718_maternal_effect2.84976287
6MP0005671_abnormal_response_to2.79760844
7MP0009333_abnormal_splenocyte_physiolog2.40421119
8MP0003868_abnormal_feces_composition2.32421845
9MP0002693_abnormal_pancreas_physiology2.28556958
10MP0001835_abnormal_antigen_presentation2.19649320
11MP0008260_abnormal_autophagy2.15962479
12MP0000685_abnormal_immune_system2.14280576
13MP0009785_altered_susceptibility_to2.12922815
14MP0008877_abnormal_DNA_methylation2.12309550
15MP0003436_decreased_susceptibility_to2.04712458
16MP0003828_pulmonary_edema2.04378830
17MP0003656_abnormal_erythrocyte_physiolo2.01279028
18MP0003763_abnormal_thymus_physiology1.97961613
19MP0009278_abnormal_bone_marrow1.96424836
20MP0001545_abnormal_hematopoietic_system1.95958632
21MP0005397_hematopoietic_system_phenotyp1.95958632
22MP0005076_abnormal_cell_differentiation1.95349822
23MP0002148_abnormal_hypersensitivity_rea1.93923072
24MP0001944_abnormal_pancreas_morphology1.92035550
25MP0000678_abnormal_parathyroid_gland1.90897316
26MP0002405_respiratory_system_inflammati1.89487359
27MP0005174_abnormal_tail_pigmentation1.89185719
28MP0005000_abnormal_immune_tolerance1.88248748
29MP0000490_abnormal_crypts_of1.85114638
30MP0005025_abnormal_response_to1.79931456
31MP0003191_abnormal_cellular_cholesterol1.79052157
32MP0005387_immune_system_phenotype1.78180627
33MP0001790_abnormal_immune_system1.78180627
34MP0008057_abnormal_DNA_replication1.77813208
35MP0002837_dystrophic_cardiac_calcinosis1.77064598
36MP0003303_peritoneal_inflammation1.76271974
37MP0002933_joint_inflammation1.75948648
38MP0003724_increased_susceptibility_to1.71668601
39MP0004510_myositis1.69066430
40MP0002398_abnormal_bone_marrow1.67830880
41MP0002419_abnormal_innate_immunity1.67210596
42MP0005220_abnormal_exocrine_pancreas1.65199957
43MP0002420_abnormal_adaptive_immunity1.63588806
44MP0003172_abnormal_lysosome_physiology1.62897963
45MP0001819_abnormal_immune_cell1.62570159
46MP0003890_abnormal_embryonic-extraembry1.62192504
47MP0002132_abnormal_respiratory_system1.59923395
48MP0008789_abnormal_olfactory_epithelium1.58003830
49MP0005451_abnormal_body_composition1.56754040
50MP0010155_abnormal_intestine_physiology1.55241129
51MP0002723_abnormal_immune_serum1.55226619
52MP0002452_abnormal_antigen_presenting1.54215390
53MP0004147_increased_porphyrin_level1.54071548
54MP0001800_abnormal_humoral_immune1.53668742
55MP0002138_abnormal_hepatobiliary_system1.49691892
56MP0010368_abnormal_lymphatic_system1.46587863
57MP0000716_abnormal_immune_system1.44455070
58MP0003866_abnormal_defecation1.42692284
59MP0001188_hyperpigmentation1.40318030
60MP0002396_abnormal_hematopoietic_system1.39434774
61MP0005499_abnormal_olfactory_system1.38238133
62MP0005394_taste/olfaction_phenotype1.38238133
63MP0000689_abnormal_spleen_morphology1.36972723
64MP0003221_abnormal_cardiomyocyte_apopto1.35596309
65MP0001853_heart_inflammation1.34937305
66MP0001845_abnormal_inflammatory_respons1.33663435
67MP0002429_abnormal_blood_cell1.33362960
68MP0001873_stomach_inflammation1.32833429
69MP0010352_gastrointestinal_tract_polyps1.28824579
70MP0008004_abnormal_stomach_pH1.28608415
71MP0006082_CNS_inflammation1.26678771
72MP0002722_abnormal_immune_system1.26032100
73MP0005395_other_phenotype1.26023269
74MP0005310_abnormal_salivary_gland1.24515688
75MP0005084_abnormal_gallbladder_morpholo1.23803889
76MP0001348_abnormal_lacrimal_gland1.22492923
77MP0002127_abnormal_cardiovascular_syste1.22161161
78MP0003186_abnormal_redox_activity1.22090591
79MP0003693_abnormal_embryo_hatching1.21752220
80MP0003646_muscle_fatigue1.21568113
81MP0002928_abnormal_bile_duct1.20894675
82MP0003091_abnormal_cell_migration1.20140445
83MP0009840_abnormal_foam_cell1.18716307
84MP0003787_abnormal_imprinting1.18214868
85MP0004484_altered_response_of1.16943040
86MP0002277_abnormal_respiratory_mucosa1.16881778
87MP0002009_preneoplasia1.15359349
88MP0006072_abnormal_retinal_apoptosis1.14154911
89MP0000703_abnormal_thymus_morphology1.12812762
90MP0000343_altered_response_to1.11030900
91MP0002019_abnormal_tumor_incidence1.10919555
92MP0002166_altered_tumor_susceptibility1.10622915
93MP0005464_abnormal_platelet_physiology1.09571804
94MP0000015_abnormal_ear_pigmentation1.09543771
95MP0005621_abnormal_cell_physiology1.06176298
96MP0002332_abnormal_exercise_endurance1.05850038
97MP0000858_altered_metastatic_potential1.04998418
98MP0004264_abnormal_extraembryonic_tissu1.04650221
99MP0001533_abnormal_skeleton_physiology1.04318032
100MP0003699_abnormal_female_reproductive1.02142809
101MP0008469_abnormal_protein_level1.01666195
102MP0001986_abnormal_taste_sensitivity0.99324574
103MP0003183_abnormal_peptide_metabolism0.98966664
104MP0005257_abnormal_intraocular_pressure0.97979579
105MP0002078_abnormal_glucose_homeostasis0.95725229
106MP0005645_abnormal_hypothalamus_physiol0.95640087
107MP0001929_abnormal_gametogenesis0.94893393
108MP0006036_abnormal_mitochondrial_physio0.93846093
109MP0005334_abnormal_fat_pad0.92547820
110MP0002006_tumorigenesis0.90095557
111MP0004043_abnormal_pH_regulation0.89668354
112MP0000013_abnormal_adipose_tissue0.89137427
113MP0004808_abnormal_hematopoietic_stem0.86619696
114MP0000465_gastrointestinal_hemorrhage0.86364917
115MP0003252_abnormal_bile_duct0.84686151
116MP0001851_eye_inflammation0.83781359
117MP0005367_renal/urinary_system_phenotyp0.83624403
118MP0000516_abnormal_urinary_system0.83624403
119MP0006054_spinal_hemorrhage0.83615074
120MP0001730_embryonic_growth_arrest0.83355135
121MP0005075_abnormal_melanosome_morpholog0.83031195
122MP0005266_abnormal_metabolism0.81013425
123MP0001915_intracranial_hemorrhage0.80003989
124MP0003300_gastrointestinal_ulcer0.78855614
125MP0009115_abnormal_fat_cell0.78549888
126MP0003943_abnormal_hepatobiliary_system0.77115827
127MP0003795_abnormal_bone_structure0.76862390
128MP0005375_adipose_tissue_phenotype0.75877397
129MP0003567_abnormal_fetal_cardiomyocyte0.75565904
130MP0002095_abnormal_skin_pigmentation0.75359509
131MP0004215_abnormal_myocardial_fiber0.74210442
132MP0005248_abnormal_Harderian_gland0.73190810
133MP0003690_abnormal_glial_cell0.73056128
134MP0004185_abnormal_adipocyte_glucose0.72852495
135MP0000003_abnormal_adipose_tissue0.72683880
136MP0004130_abnormal_muscle_cell0.72233192
137MP0002638_abnormal_pupillary_reflex0.72185639
138MP0006138_congestive_heart_failure0.71873973
139MP0005409_darkened_coat_color0.71445667
140MP0001664_abnormal_digestion0.71402212
141MP0009780_abnormal_chondrocyte_physiolo0.71064371
142MP0005384_cellular_phenotype0.71017919
143MP0008874_decreased_physiological_sensi0.70738548
144MP0009643_abnormal_urine_homeostasis0.70426655
145MP0002210_abnormal_sex_determination0.69850325
146MP0002909_abnormal_adrenal_gland0.68605760
147MP0000598_abnormal_liver_morphology0.68597550
148MP0005379_endocrine/exocrine_gland_phen0.68433942
149MP0005535_abnormal_body_temperature0.68361218
150MP0000609_abnormal_liver_physiology0.68302994
151MP0009764_decreased_sensitivity_to0.68097910
152MP0005647_abnormal_sex_gland0.66455518
153MP0005666_abnormal_adipose_tissue0.64718387

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.35888422
2Dysostosis multiplex (HP:0000943)4.27655699
3Mucopolysacchariduria (HP:0008155)4.01557772
4Urinary glycosaminoglycan excretion (HP:0003541)4.01557772
5Abnormality of polysaccharide metabolism (HP:0011012)3.47355393
6Abnormality of glycosaminoglycan metabolism (HP:0004371)3.47355393
7Abnormality of mucopolysaccharide metabolism (HP:0011020)3.47355393
8Vacuolated lymphocytes (HP:0001922)3.33275653
9Conjunctival telangiectasia (HP:0000524)3.32897380
10Late onset (HP:0003584)3.31423398
11Aplastic anemia (HP:0001915)3.29490171
12Thyroid carcinoma (HP:0002890)3.17913030
13Abnormality of the vasculature of the conjunctiva (HP:0008054)3.16194423
14Hyperinsulinemic hypoglycemia (HP:0000825)3.15841130
15Increased IgM level (HP:0003496)3.14456804
16Abnormal protein glycosylation (HP:0012346)3.12282263
17Abnormal glycosylation (HP:0012345)3.12282263
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.12282263
19Abnormal protein N-linked glycosylation (HP:0012347)3.12282263
20Abnormality of endocrine pancreas physiology (HP:0012093)3.03864100
21Abnormality of the pancreatic islet cells (HP:0006476)3.03864100
22Large for gestational age (HP:0001520)3.00939282
23Recurrent abscess formation (HP:0002722)3.00658445
24Joint stiffness (HP:0001387)3.00537059
25Progressive neurologic deterioration (HP:0002344)2.97262823
26Elevated erythrocyte sedimentation rate (HP:0003565)2.96234378
27Myositis (HP:0100614)2.95732972
28Orchitis (HP:0100796)2.91224398
29Spontaneous hematomas (HP:0007420)2.88781233
30Interstitial pulmonary disease (HP:0006530)2.84973164
31Hypochromic microcytic anemia (HP:0004840)2.84122802
32Type I transferrin isoform profile (HP:0003642)2.78966467
33Abnormality of the heme biosynthetic pathway (HP:0010472)2.76665788
34Asymmetric septal hypertrophy (HP:0001670)2.76208679
35Abnormality of macrophages (HP:0004311)2.75478639
36Optic neuritis (HP:0100653)2.74880905
37Retrobulbar optic neuritis (HP:0100654)2.74880905
38IgM deficiency (HP:0002850)2.74864812
39Episodic fever (HP:0001954)2.72143507
40Pancreatic islet-cell hyperplasia (HP:0004510)2.69489926
41Loss of speech (HP:0002371)2.69006820
42Osteomalacia (HP:0002749)2.68568186
43Abnormality of T cell physiology (HP:0011840)2.66387150
44Cone-rod dystrophy (HP:0000548)2.65737462
45Postural tremor (HP:0002174)2.59633744
46Petechiae (HP:0000967)2.58160272
47Hypercortisolism (HP:0001578)2.55649781
48Generalized aminoaciduria (HP:0002909)2.55358559
49Exercise-induced myalgia (HP:0003738)2.52661304
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52132339
51Hypoglycemic coma (HP:0001325)2.45631584
52Deep palmar crease (HP:0006191)2.44607204
53Symptomatic seizures (HP:0011145)2.44232201
54Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.43047401
55Gastrointestinal inflammation (HP:0004386)2.41800093
56Thrombocytosis (HP:0001894)2.41694814
57Eczematoid dermatitis (HP:0000976)2.41125616
58Reduced antithrombin III activity (HP:0001976)2.40517106
59Recurrent bacterial skin infections (HP:0005406)2.39051953
60Osteomyelitis (HP:0002754)2.34886603
61Muscle stiffness (HP:0003552)2.33976455
62Abnormality of cells of the erythroid lineage (HP:0012130)2.32174080
63Inflammation of the large intestine (HP:0002037)2.30272178
64Microcytic anemia (HP:0001935)2.30095599
65Poikiloderma (HP:0001029)2.30077433
66Ketoacidosis (HP:0001993)2.28076783
67Abnormal number of erythroid precursors (HP:0012131)2.27028882
68Striae distensae (HP:0001065)2.25953072
69Beaking of vertebral bodies (HP:0004568)2.24756238
70Growth hormone excess (HP:0000845)2.24628717
71Hypoglycemic seizures (HP:0002173)2.23273295
72Ovoid vertebral bodies (HP:0003300)2.23120473
73Insulin resistance (HP:0000855)2.22045607
74Pustule (HP:0200039)2.21232618
75Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19395753
76Hematochezia (HP:0002573)2.17590339
77Mucosal telangiectasiae (HP:0100579)2.16340256
78Increased serum ferritin (HP:0003281)2.15836261
79Abnormality of T cells (HP:0002843)2.15727690
80Keratoconjunctivitis sicca (HP:0001097)2.15288153
81Unilateral renal agenesis (HP:0000122)2.15053242
82Hepatic necrosis (HP:0002605)2.14946079
83Recurrent fungal infections (HP:0002841)2.14397885
84Male infertility (HP:0003251)2.12773591
85Sensorimotor neuropathy (HP:0007141)2.11584296
86Lymphedema (HP:0001004)2.11159791
87Polycythemia (HP:0001901)2.09054951
88Urticaria (HP:0001025)2.08710862
89Rimmed vacuoles (HP:0003805)2.07365096
90Generalized hyperpigmentation (HP:0007440)2.06817152
91Gastrointestinal stroma tumor (HP:0100723)2.06814993
92Abnormal delayed hypersensitivity skin test (HP:0002963)2.05985245
93Ankle clonus (HP:0011448)2.05497075
94Abnormal gallbladder morphology (HP:0012437)2.03402840
95Gastrointestinal infarctions (HP:0005244)2.01557240
96Infertility (HP:0000789)2.01515593
97Vertebral hypoplasia (HP:0008417)2.01262437
98Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.01262437
99Abnormality of the fovea (HP:0000493)2.01221909
100Diaphragmatic weakness (HP:0009113)2.01162973
101Dysdiadochokinesis (HP:0002075)1.99572451
102IgA deficiency (HP:0002720)1.99168119
103Intestinal atresia (HP:0011100)1.98657212
104Amyotrophic lateral sclerosis (HP:0007354)1.97830550
105Abnormal tarsal ossification (HP:0008369)1.97308157
106Decreased central vision (HP:0007663)1.95506041
107Premature graying of hair (HP:0002216)1.95302111
108Colitis (HP:0002583)1.95128250
109Increased IgE level (HP:0003212)1.93834818
110Stomatitis (HP:0010280)1.93714038
111Facial hemangioma (HP:0000329)1.93422958
112Abnormality of chromosome segregation (HP:0002916)1.93088850
113Recurrent viral infections (HP:0004429)1.92887005
114Cellulitis (HP:0100658)1.92693796
115Exertional dyspnea (HP:0002875)1.91882780
116Exercise-induced muscle cramps (HP:0003710)1.91504591
117Hepatocellular necrosis (HP:0001404)1.90915644
118Anhidrosis (HP:0000970)1.90494743
119Irregular vertebral endplates (HP:0003301)1.90244515
120Hyperparathyroidism (HP:0000843)1.89729001
121Cholelithiasis (HP:0001081)1.89653806
122Flat capital femoral epiphysis (HP:0003370)1.89319626
123Coxa valga (HP:0002673)1.87956217
124Abnormality of abdominal situs (HP:0011620)1.87316777
125Abdominal situs inversus (HP:0003363)1.87316777
126Hypophosphatemic rickets (HP:0004912)1.86407517
127Nausea (HP:0002018)1.86247565
128Prolonged bleeding time (HP:0003010)1.86129441
129Truncal obesity (HP:0001956)1.85587216
130Lower limb hyperreflexia (HP:0002395)1.84821693
131Pulmonary fibrosis (HP:0002206)1.84100137
132Easy fatigability (HP:0003388)1.83688257
133Increased variability in muscle fiber diameter (HP:0003557)1.83537652
134Meningitis (HP:0001287)1.83169187
135Keratoconjunctivitis (HP:0001096)1.82502715
136Abnormality of iron homeostasis (HP:0011031)1.82374172
137Mediastinal lymphadenopathy (HP:0100721)1.82136270
138Menstrual irregularities (HP:0000858)1.81738495
139Autoamputation (HP:0001218)1.81527545
140Malnutrition (HP:0004395)1.81089578
141Abnormality of the vertebral endplates (HP:0005106)1.80441326
142Recurrent bronchitis (HP:0002837)1.80127432
143Abnormality of the hip-girdle musculature (HP:0001445)1.79834671
144Abnormality of the musculature of the pelvis (HP:0001469)1.79834671
145Insulin-resistant diabetes mellitus (HP:0000831)1.79654781
146Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79570785
147Progressive muscle weakness (HP:0003323)1.79473241
148Metaphyseal irregularity (HP:0003025)1.79198736
149Pelvic girdle muscle weakness (HP:0003749)1.78650183
150Abnormal gallbladder physiology (HP:0012438)1.78493286
151Cholecystitis (HP:0001082)1.78493286
152Cranial hyperostosis (HP:0004437)1.77647892
153Cervical subluxation (HP:0003308)1.77441441
154Albinism (HP:0001022)1.77023478
155Microretrognathia (HP:0000308)1.76927168
156Muscle fiber splitting (HP:0003555)1.76286299
157Congenital malformation of the right heart (HP:0011723)1.76063311
158Double outlet right ventricle (HP:0001719)1.76063311
159Clonus (HP:0002169)1.74947390
160Diminished motivation (HP:0000745)1.74737228
161Patent foramen ovale (HP:0001655)1.74307887
162Generalized myoclonic seizures (HP:0002123)1.73608222
163IgG deficiency (HP:0004315)1.72495089
164Vasculitis (HP:0002633)1.72168437
165Vertebral compression fractures (HP:0002953)1.71976579
166Hypergammaglobulinemia (HP:0010702)1.71838539
167Recurrent gram-negative bacterial infections (HP:0005420)1.71620187
168Ulnar deviation of the wrist (HP:0003049)1.71556276
169Enlarged epiphyses (HP:0010580)1.71528321
170T lymphocytopenia (HP:0005403)1.71088822
171Ventricular tachycardia (HP:0004756)1.71038621
172Centrally nucleated skeletal muscle fibers (HP:0003687)1.70895867
173Chest pain (HP:0100749)1.70426885
174Supernumerary spleens (HP:0009799)1.70230493
175Fair hair (HP:0002286)1.70101370
176Gonadotropin excess (HP:0000837)1.69618674
177Mutism (HP:0002300)1.68044145
178Apathy (HP:0000741)1.67331611
179Poikilocytosis (HP:0004447)1.66207013
180Leukocytosis (HP:0001974)1.64764206
181Fatigue (HP:0012378)1.63883047
182Hypokinesia (HP:0002375)1.63611553
183Limb hypertonia (HP:0002509)1.63551651
184Absent/shortened dynein arms (HP:0200106)1.62846921
185Dynein arm defect of respiratory motile cilia (HP:0012255)1.62846921
186Abnormality of skeletal muscle fiber size (HP:0012084)1.62647326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.12713989
2PIM23.06889620
3MAP3K112.95488631
4MAP2K22.75006362
5NME22.66075018
6TIE12.61710587
7PRPF4B2.53833930
8TAOK32.48731164
9MAP3K92.46695873
10ERN12.37094160
11TRIB32.32487545
12MAP3K62.23046131
13NEK92.22685648
14MAP4K12.19449988
15BLK2.14834485
16MAP3K102.04892261
17FLT32.00552455
18CDK191.93523450
19ACVR1B1.90906682
20BRAF1.88343173
21HIPK21.82105344
22BRD41.79750619
23PKN21.78907388
24TEC1.75431169
25MATK1.70322641
26KSR11.66579034
27IRAK41.66172831
28BTK1.59810532
29NME11.56100541
30CSK1.54819466
31TBK11.54691829
32DDR21.50922990
33ICK1.48682200
34PRKD21.47372170
35SCYL21.41779842
36IRAK31.39301450
37KIT1.36948939
38MAP2K41.33974191
39TGFBR21.27345591
40FES1.22980015
41KDR1.21900447
42SGK21.21102577
43MAP3K11.19870179
44TRIM281.19813824
45PIM11.19367037
46SGK31.18144242
47STK241.18024095
48ZAP701.17427735
49PIK3CA1.14929826
50YES11.14772455
51STK161.13402697
52ERBB31.13160223
53CDK61.09483927
54INSRR1.07183340
55MAP3K21.07115377
56AKT31.06182807
57CDC71.05339006
58RPS6KA61.02088148
59MAP3K41.01733605
60DYRK1B1.01230244
61JAK31.00659459
62RPS6KL10.99135506
63RPS6KC10.99135506
64MAP3K140.97743589
65LYN0.97418329
66TESK10.96789691
67MAP3K30.96662551
68IKBKB0.96352654
69PASK0.95847559
70IKBKE0.95126263
71NEK20.94279989
72MAP2K30.93468193
73SYK0.91972922
74MAPK120.91714602
75TXK0.91226118
76TYK20.89342433
77GRK60.89047120
78VRK10.87611400
79CDK70.87193157
80CDK80.86831473
81FGFR30.85300724
82MARK30.84365931
83CAMKK20.82506327
84WNK10.79386333
85STK110.78018466
86MAPK70.77998719
87CDK120.77881001
88BCKDK0.77830794
89RIPK40.75685084
90MAPK110.75385264
91RAF10.74802833
92MST1R0.74514758
93ARAF0.72779510
94CDK40.71527384
95JAK10.70446596
96DYRK30.70407324
97ITK0.70377412
98RPS6KB20.69882587
99DAPK10.69424349
100CSF1R0.69046522
101CHUK0.67775590
102PDK10.67219275
103MST40.66593870
104MUSK0.66271122
105NEK60.65639525
106SIK30.65609294
107JAK20.65569197
108MARK20.64285445
109TAOK20.64062517
110KSR20.63716716
111GRK70.63509548
112TAOK10.62781067
113MOS0.61843964
114NLK0.61503429
115TNIK0.61490245
116PNCK0.61441603
117OXSR10.61082703
118LCK0.59906327
119ILK0.59622249
120STK100.59205197
121MAP3K50.58564849
122UHMK10.58352095
123SGK4940.58352075
124SGK2230.58352075
125FGR0.57361631
126RPS6KA10.57127760
127MAP3K80.56919529
128TRPM70.54100356
129CDC42BPA0.52806252
130ABL20.52650041
131MAP3K130.52339658
132OBSCN0.51940969
133EPHA30.51650887
134FRK0.51096861
135MAP2K70.50625171
136IRAK10.49495204
137BMPR20.48214545
138BCR0.47994927
139TLK10.47567186
140CCNB10.43581435
141HCK0.43313723
142PRKG10.42483207
143MAPKAPK20.42412847
144CAMK40.41977670
145PIK3CG0.39946725
146RPS6KA40.38349019
147EPHB10.38224646
148PRKG20.38032796
149CDK90.37960494
150PTK2B0.37876996
151CAMK1G0.37354494
152EGFR0.36285164
153PINK10.33645142

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.67678618
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.60667750
3Dorso-ventral axis formation_Homo sapiens_hsa043202.73572900
4Other glycan degradation_Homo sapiens_hsa005112.52059202
5DNA replication_Homo sapiens_hsa030302.45410079
6Base excision repair_Homo sapiens_hsa034102.25166380
7Folate biosynthesis_Homo sapiens_hsa007902.03782610
8Leishmaniasis_Homo sapiens_hsa051401.91187640
9Collecting duct acid secretion_Homo sapiens_hsa049661.83654988
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81741933
11Caffeine metabolism_Homo sapiens_hsa002321.74278406
12Renal cell carcinoma_Homo sapiens_hsa052111.69565195
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65242395
14Primary immunodeficiency_Homo sapiens_hsa053401.62341789
15Mismatch repair_Homo sapiens_hsa034301.61434858
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.61352898
17Sulfur metabolism_Homo sapiens_hsa009201.60790669
18Ribosome_Homo sapiens_hsa030101.57423351
19Inositol phosphate metabolism_Homo sapiens_hsa005621.55243729
20Acute myeloid leukemia_Homo sapiens_hsa052211.54492325
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54086020
22FoxO signaling pathway_Homo sapiens_hsa040681.53646983
23Legionellosis_Homo sapiens_hsa051341.53604197
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53237670
25B cell receptor signaling pathway_Homo sapiens_hsa046621.45001527
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.43493182
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41564351
28Type I diabetes mellitus_Homo sapiens_hsa049401.40898815
29Regulation of autophagy_Homo sapiens_hsa041401.40312679
30Thyroid cancer_Homo sapiens_hsa052161.39069586
31Galactose metabolism_Homo sapiens_hsa000521.35976454
32Oocyte meiosis_Homo sapiens_hsa041141.34879218
33N-Glycan biosynthesis_Homo sapiens_hsa005101.34255684
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32459847
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31509476
36Endometrial cancer_Homo sapiens_hsa052131.27150994
37Bladder cancer_Homo sapiens_hsa052191.23217408
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22151020
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21742321
40Phagosome_Homo sapiens_hsa041451.21507489
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20149086
42Basal transcription factors_Homo sapiens_hsa030221.19685433
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19674770
44Gap junction_Homo sapiens_hsa045401.16955025
45Shigellosis_Homo sapiens_hsa051311.14523846
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13031739
47Lysosome_Homo sapiens_hsa041421.10608349
48Long-term depression_Homo sapiens_hsa047301.09413058
49Osteoclast differentiation_Homo sapiens_hsa043801.09034044
50Hepatitis B_Homo sapiens_hsa051611.06877515
51Asthma_Homo sapiens_hsa053101.05931647
52Measles_Homo sapiens_hsa051621.05635134
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04319491
54Herpes simplex infection_Homo sapiens_hsa051681.01774229
55Sphingolipid signaling pathway_Homo sapiens_hsa040711.01573919
56Hepatitis C_Homo sapiens_hsa051601.01474442
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.00559260
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.99751400
59Antigen processing and presentation_Homo sapiens_hsa046120.99417930
60Malaria_Homo sapiens_hsa051440.98211149
61Chronic myeloid leukemia_Homo sapiens_hsa052200.97024377
62Selenocompound metabolism_Homo sapiens_hsa004500.96108758
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95848182
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94445382
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93974881
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93770154
67Hematopoietic cell lineage_Homo sapiens_hsa046400.93607713
68Proteasome_Homo sapiens_hsa030500.92870705
69Allograft rejection_Homo sapiens_hsa053300.92407101
70Prolactin signaling pathway_Homo sapiens_hsa049170.91443204
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89168002
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88828640
73Renin secretion_Homo sapiens_hsa049240.87457673
74Endocytosis_Homo sapiens_hsa041440.87288172
75Synaptic vesicle cycle_Homo sapiens_hsa047210.86706861
76RNA degradation_Homo sapiens_hsa030180.86094282
77Sulfur relay system_Homo sapiens_hsa041220.85039315
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84873891
79VEGF signaling pathway_Homo sapiens_hsa043700.84786526
80Glioma_Homo sapiens_hsa052140.84699036
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83897889
82Tuberculosis_Homo sapiens_hsa051520.83229801
83Homologous recombination_Homo sapiens_hsa034400.82996363
84AMPK signaling pathway_Homo sapiens_hsa041520.82074793
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.81809694
86Choline metabolism in cancer_Homo sapiens_hsa052310.81083323
87Apoptosis_Homo sapiens_hsa042100.80945914
88Pertussis_Homo sapiens_hsa051330.80717417
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80391886
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78941439
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77092223
92p53 signaling pathway_Homo sapiens_hsa041150.77033891
93Circadian rhythm_Homo sapiens_hsa047100.76240671
94GnRH signaling pathway_Homo sapiens_hsa049120.75563215
95Vibrio cholerae infection_Homo sapiens_hsa051100.75314615
96Influenza A_Homo sapiens_hsa051640.73920700
97Graft-versus-host disease_Homo sapiens_hsa053320.73897162
98Viral myocarditis_Homo sapiens_hsa054160.73471800
99Staphylococcus aureus infection_Homo sapiens_hsa051500.73145127
100Pancreatic cancer_Homo sapiens_hsa052120.73143154
101Toxoplasmosis_Homo sapiens_hsa051450.72400759
102Spliceosome_Homo sapiens_hsa030400.72192376
103TNF signaling pathway_Homo sapiens_hsa046680.72028356
104Nucleotide excision repair_Homo sapiens_hsa034200.71279963
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70281031
106Long-term potentiation_Homo sapiens_hsa047200.69005686
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68950951
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67561329
109Pyrimidine metabolism_Homo sapiens_hsa002400.66807911
110ErbB signaling pathway_Homo sapiens_hsa040120.65706104
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63841630
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.63654880
113Cell cycle_Homo sapiens_hsa041100.62312971
114Prion diseases_Homo sapiens_hsa050200.62243264
115Phototransduction_Homo sapiens_hsa047440.61904794
116African trypanosomiasis_Homo sapiens_hsa051430.61485106
117T cell receptor signaling pathway_Homo sapiens_hsa046600.61261942
118Amoebiasis_Homo sapiens_hsa051460.58624735
119Ovarian steroidogenesis_Homo sapiens_hsa049130.58308106
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58305076
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56220613
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55651637
123Type II diabetes mellitus_Homo sapiens_hsa049300.55031314
124Oxidative phosphorylation_Homo sapiens_hsa001900.54871260
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54617778
126Non-small cell lung cancer_Homo sapiens_hsa052230.54371254
127Parkinsons disease_Homo sapiens_hsa050120.53555154
128Salmonella infection_Homo sapiens_hsa051320.52582419
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.51075755
130Dopaminergic synapse_Homo sapiens_hsa047280.50389103
131Viral carcinogenesis_Homo sapiens_hsa052030.48850625
132Chemokine signaling pathway_Homo sapiens_hsa040620.48440224
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47823358
134mTOR signaling pathway_Homo sapiens_hsa041500.47716052
135HIF-1 signaling pathway_Homo sapiens_hsa040660.47477289
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46609271
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45703149
138Estrogen signaling pathway_Homo sapiens_hsa049150.45559979
139RNA polymerase_Homo sapiens_hsa030200.45520908
140Prostate cancer_Homo sapiens_hsa052150.45454108
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44828821
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44317391
143Insulin resistance_Homo sapiens_hsa049310.43725575
144HTLV-I infection_Homo sapiens_hsa051660.42110672
145Rheumatoid arthritis_Homo sapiens_hsa053230.39498423
146Insulin secretion_Homo sapiens_hsa049110.39188450
147Insulin signaling pathway_Homo sapiens_hsa049100.37544224
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36432918
149Colorectal cancer_Homo sapiens_hsa052100.34072929
150Epstein-Barr virus infection_Homo sapiens_hsa051690.32908546

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