FAM118B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.13870665
2cilium or flagellum-dependent cell motility (GO:0001539)5.01581572
3establishment of integrated proviral latency (GO:0075713)4.95205288
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.45612779
5microtubule depolymerization (GO:0007019)4.21114126
6establishment of viral latency (GO:0019043)4.13788283
7DNA methylation involved in gamete generation (GO:0043046)4.11917601
8fusion of sperm to egg plasma membrane (GO:0007342)4.11519247
9sperm-egg recognition (GO:0035036)3.99482973
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.98835205
11DNA damage response, detection of DNA damage (GO:0042769)3.97373335
12male meiosis (GO:0007140)3.97313653
13proteasome assembly (GO:0043248)3.96665689
14multicellular organism reproduction (GO:0032504)3.92100946
15axonemal dynein complex assembly (GO:0070286)3.90090582
16IMP biosynthetic process (GO:0006188)3.88216980
17cullin deneddylation (GO:0010388)3.86259681
18binding of sperm to zona pellucida (GO:0007339)3.83113373
19protein deneddylation (GO:0000338)3.73502745
20protein localization to kinetochore (GO:0034501)3.70763864
217-methylguanosine mRNA capping (GO:0006370)3.67873741
22RNA capping (GO:0036260)3.65113093
237-methylguanosine RNA capping (GO:0009452)3.65113093
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62648506
25cell wall macromolecule catabolic process (GO:0016998)3.59300001
26cell wall macromolecule metabolic process (GO:0044036)3.59300001
27maturation of 5.8S rRNA (GO:0000460)3.57553103
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56272073
29synaptonemal complex organization (GO:0070193)3.56028630
30synaptonemal complex assembly (GO:0007130)3.55167866
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53876244
32motile cilium assembly (GO:0044458)3.53164752
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.52718198
34termination of RNA polymerase III transcription (GO:0006386)3.52352159
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.52352159
36spindle checkpoint (GO:0031577)3.46592445
37cell-cell recognition (GO:0009988)3.45394759
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44633611
39GTP biosynthetic process (GO:0006183)3.41326949
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.40872907
41NADH dehydrogenase complex assembly (GO:0010257)3.40872907
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40872907
43DNA ligation (GO:0006266)3.39972926
44DNA double-strand break processing (GO:0000729)3.36964666
45tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36735790
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36735790
47L-serine metabolic process (GO:0006563)3.36704986
48transcription elongation from RNA polymerase I promoter (GO:0006362)3.36596984
49protein complex biogenesis (GO:0070271)3.36328892
50mitochondrial respiratory chain complex assembly (GO:0033108)3.35605534
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34796575
52ATP synthesis coupled proton transport (GO:0015986)3.34796575
53CENP-A containing nucleosome assembly (GO:0034080)3.33538860
54negative regulation of mitotic sister chromatid separation (GO:2000816)3.32954746
55negative regulation of sister chromatid segregation (GO:0033046)3.32954746
56negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.32954746
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.32954746
58negative regulation of mitotic sister chromatid segregation (GO:0033048)3.32954746
59negative regulation of ligase activity (GO:0051352)3.32400115
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.32400115
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.32179400
62somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32179400
63chromatin remodeling at centromere (GO:0031055)3.31827510
64IMP metabolic process (GO:0046040)3.31247118
65mitotic spindle checkpoint (GO:0071174)3.30293056
66DNA deamination (GO:0045006)3.25608099
67DNA catabolic process, exonucleolytic (GO:0000738)3.25480309
68establishment of chromosome localization (GO:0051303)3.24155503
69mitotic metaphase plate congression (GO:0007080)3.24076390
70negative regulation of chromosome segregation (GO:0051985)3.23781928
71protein neddylation (GO:0045116)3.22888192
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21494367
73signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20059238
74signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20059238
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20059238
76histone exchange (GO:0043486)3.18536544
77regulation of helicase activity (GO:0051095)3.18324177
78sperm motility (GO:0030317)3.17659765
79termination of RNA polymerase I transcription (GO:0006363)3.17522557
80guanosine-containing compound biosynthetic process (GO:1901070)3.17191199
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16916029
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16916029
83DNA replication checkpoint (GO:0000076)3.15299156
84rRNA methylation (GO:0031167)3.14685416
85protein localization to chromosome, centromeric region (GO:0071459)3.14188549
86ribosomal large subunit biogenesis (GO:0042273)3.12056261
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12010230
88single strand break repair (GO:0000012)3.11231936
89epithelial cilium movement (GO:0003351)3.11151122
90negative regulation of DNA recombination (GO:0045910)3.10660560
91regulation of ligase activity (GO:0051340)3.10243584
92protein targeting to mitochondrion (GO:0006626)3.09677249
93regulation of cellular amino acid metabolic process (GO:0006521)3.09294615
94transcription-coupled nucleotide-excision repair (GO:0006283)3.08349076
95signal transduction involved in cell cycle checkpoint (GO:0072395)3.08059623
96plasma membrane fusion (GO:0045026)3.07734111
97protein localization to mitochondrion (GO:0070585)3.07674877
98respiratory chain complex IV assembly (GO:0008535)3.07337133
99signal transduction involved in DNA damage checkpoint (GO:0072422)3.07079052
100signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07079052
101mitotic spindle assembly checkpoint (GO:0007094)3.06820323
102kinetochore assembly (GO:0051382)3.04735055
103peptidyl-histidine modification (GO:0018202)3.04458667
104regulation of mitochondrial translation (GO:0070129)3.03455490
105spindle assembly checkpoint (GO:0071173)3.03149673
106kinetochore organization (GO:0051383)3.02495486
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02257291
108regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02257291
109regulation of double-strand break repair via homologous recombination (GO:0010569)3.02064871
110replication fork processing (GO:0031297)3.01740518
111mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01678016
112non-recombinational repair (GO:0000726)3.01227010
113double-strand break repair via nonhomologous end joining (GO:0006303)3.01227010
114meiotic nuclear division (GO:0007126)2.99134809
115histone H2A acetylation (GO:0043968)2.98240987
116spliceosomal snRNP assembly (GO:0000387)2.97445310
117UTP biosynthetic process (GO:0006228)2.97009394
118pseudouridine synthesis (GO:0001522)2.96507029
119acrosome assembly (GO:0001675)2.95733051
120chaperone-mediated protein transport (GO:0072321)2.94534312
121nucleobase biosynthetic process (GO:0046112)2.93754443
122positive regulation of ligase activity (GO:0051351)2.93664453
123spermatid development (GO:0007286)2.92690739
124transcription elongation from RNA polymerase II promoter (GO:0006368)2.92254419
125protein-cofactor linkage (GO:0018065)2.91688017
126chromosome organization involved in meiosis (GO:0070192)2.91047923
127male meiosis I (GO:0007141)2.90949222
128DNA strand elongation involved in DNA replication (GO:0006271)2.89942087
129transcription from RNA polymerase I promoter (GO:0006360)2.89571856
130DNA replication-independent nucleosome assembly (GO:0006336)2.88659409
131DNA replication-independent nucleosome organization (GO:0034724)2.88659409
132ribosome biogenesis (GO:0042254)2.87572766
133regulation of ubiquitin-protein transferase activity (GO:0051438)2.83583944
134exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83411197
135ribosome assembly (GO:0042255)2.83348786
136microtubule polymerization or depolymerization (GO:0031109)2.83227600
137blastocyst development (GO:0001824)2.82914212
138centriole assembly (GO:0098534)2.82563598
139regulation of mitotic spindle checkpoint (GO:1903504)2.81263273
140regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81263273
141nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80905434
142purine nucleobase biosynthetic process (GO:0009113)2.80788294
143DNA-templated transcription, elongation (GO:0006354)2.80220788
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79498132
145centriole replication (GO:0007099)2.79349150
146DNA strand elongation (GO:0022616)2.77688019
147metaphase plate congression (GO:0051310)2.76627358
148regulation of cilium movement (GO:0003352)2.76151908
149meiosis I (GO:0007127)2.76014612
150ribonucleoprotein complex biogenesis (GO:0022613)2.75812181
151reproduction (GO:0000003)2.74807451
152transcription initiation from RNA polymerase I promoter (GO:0006361)2.74579846
153rRNA modification (GO:0000154)2.72098596
154epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71448844
155telomere maintenance via semi-conservative replication (GO:0032201)2.71004516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.69546603
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00192744
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.68749192
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.62359710
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.45278687
6E2F7_22180533_ChIP-Seq_HELA_Human3.35764201
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32770516
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.01454118
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81254841
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.77971008
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.63078986
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59865431
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57381445
14* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56157652
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53330170
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51752344
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45605227
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42362729
19VDR_23849224_ChIP-Seq_CD4+_Human2.34107657
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24160798
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23902676
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15405809
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14001105
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10117584
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07475113
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.99111249
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87672719
28FOXP3_21729870_ChIP-Seq_TREG_Human1.87542242
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86988232
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.86980419
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83954481
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82982676
33ELK1_19687146_ChIP-ChIP_HELA_Human1.81868550
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80174847
35DCP1A_22483619_ChIP-Seq_HELA_Human1.79991056
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.74636514
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70520998
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68455586
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67427105
40GABP_19822575_ChIP-Seq_HepG2_Human1.66222476
41XRN2_22483619_ChIP-Seq_HELA_Human1.64748538
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63224000
43TTF2_22483619_ChIP-Seq_HELA_Human1.59590355
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58640670
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57222576
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.56414802
47NANOG_16153702_ChIP-ChIP_HESCs_Human1.53636031
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52853310
49VDR_22108803_ChIP-Seq_LS180_Human1.47713874
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46022123
51ZNF274_21170338_ChIP-Seq_K562_Hela1.43256242
52FUS_26573619_Chip-Seq_HEK293_Human1.42826179
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42344181
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.41897949
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38273458
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.37596142
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36020916
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28577028
59* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28508922
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26852067
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.26807538
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24507409
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23835470
64EZH2_22144423_ChIP-Seq_EOC_Human1.20056538
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19274517
66KAP1_22055183_ChIP-Seq_ESCs_Mouse1.17015831
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16485186
68IRF1_19129219_ChIP-ChIP_H3396_Human1.14353902
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.14054281
70EWS_26573619_Chip-Seq_HEK293_Human1.13364734
71MYC_18940864_ChIP-ChIP_HL60_Human1.13143053
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12367105
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12333199
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09571927
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07843161
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07838725
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06631608
78P300_19829295_ChIP-Seq_ESCs_Human1.05719319
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03549645
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03267931
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.02110472
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99669711
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99650432
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98636547
85CIITA_25753668_ChIP-Seq_RAJI_Human0.97929011
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97799659
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.97690193
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97569541
89KDM5A_27292631_Chip-Seq_BREAST_Human0.96172343
90E2F1_21310950_ChIP-Seq_MCF-7_Human0.95805865
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95105504
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93353798
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92778782
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.91200578
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90630619
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89881133
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.89710369
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89661553
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89154814
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88292203
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87827780
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87433638
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87433638
104KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87433638
105TAF15_26573619_Chip-Seq_HEK293_Human0.87039169
106CBX2_27304074_Chip-Seq_ESCs_Mouse0.86607302
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.85670892
108TAL1_26923725_Chip-Seq_HPCs_Mouse0.85655993
109SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85339813
110SALL4_22934838_ChIP-ChIP_CD34+_Human0.84476281
111AR_21909140_ChIP-Seq_LNCAP_Human0.83323596
112P53_22387025_ChIP-Seq_ESCs_Mouse0.83120198
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.82674761
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82381700
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81451745
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80908520
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80752349
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80399875
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.80132910
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79990431
121P300_18555785_Chip-Seq_ESCs_Mouse0.79745122
122KLF4_18555785_Chip-Seq_ESCs_Mouse0.79683560
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77046867
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73109474
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73010962
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72027495
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71098016
128TFEB_21752829_ChIP-Seq_HELA_Human0.70638622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.26456570
2MP0008877_abnormal_DNA_methylation4.08709684
3MP0005410_abnormal_fertilization4.01234666
4MP0008058_abnormal_DNA_repair3.66599009
5MP0010094_abnormal_chromosome_stability3.49071524
6MP0003111_abnormal_nucleus_morphology3.13246762
7MP0006292_abnormal_olfactory_placode2.89016576
8MP0004957_abnormal_blastocyst_morpholog2.67063880
9MP0003077_abnormal_cell_cycle2.63605763
10MP0001929_abnormal_gametogenesis2.60976745
11MP0008057_abnormal_DNA_replication2.60377072
12MP0003941_abnormal_skin_development2.60315970
13MP0001188_hyperpigmentation2.39112335
14MP0002210_abnormal_sex_determination2.38900052
15MP0003718_maternal_effect2.37670479
16MP0003698_abnormal_male_reproductive2.37666767
17MP0003786_premature_aging2.35653587
18MP0008007_abnormal_cellular_replicative2.20769964
19MP0008932_abnormal_embryonic_tissue2.19178554
20MP0003186_abnormal_redox_activity2.13267397
21MP0002254_reproductive_system_inflammat2.08226596
22MP0005394_taste/olfaction_phenotype2.05115092
23MP0005499_abnormal_olfactory_system2.05115092
24MP0002736_abnormal_nociception_after2.03087502
25MP0002102_abnormal_ear_morphology2.01957140
26MP0001145_abnormal_male_reproductive1.95244495
27MP0004215_abnormal_myocardial_fiber1.94079594
28MP0009697_abnormal_copulation1.86942361
29MP0000653_abnormal_sex_gland1.78241264
30MP0006036_abnormal_mitochondrial_physio1.71868382
31MP0002837_dystrophic_cardiac_calcinosis1.71111427
32MP0005171_absent_coat_pigmentation1.68512593
33MP0002163_abnormal_gland_morphology1.67353701
34MP0001529_abnormal_vocalization1.65428502
35MP0000566_synostosis1.57030955
36MP0008260_abnormal_autophagy1.55616257
37MP0006054_spinal_hemorrhage1.52041925
38MP0001986_abnormal_taste_sensitivity1.41759035
39MP0002161_abnormal_fertility/fecundity1.36540390
40MP0002638_abnormal_pupillary_reflex1.34814209
41MP0002653_abnormal_ependyma_morphology1.33538495
42MP0009379_abnormal_foot_pigmentation1.32700249
43MP0003806_abnormal_nucleotide_metabolis1.30882176
44MP0004084_abnormal_cardiac_muscle1.30156247
45MP0002233_abnormal_nose_morphology1.28778586
46MP0001905_abnormal_dopamine_level1.28547099
47MP0000015_abnormal_ear_pigmentation1.27849558
48MP0001346_abnormal_lacrimal_gland1.24106569
49MP0003880_abnormal_central_pattern1.23756039
50MP0003123_paternal_imprinting1.20364177
51MP0003315_abnormal_perineum_morphology1.20264095
52MP0003567_abnormal_fetal_cardiomyocyte1.19347599
53MP0005409_darkened_coat_color1.18949769
54MP0002084_abnormal_developmental_patter1.17930633
55MP0008995_early_reproductive_senescence1.17711744
56MP0002277_abnormal_respiratory_mucosa1.17706811
57MP0003121_genomic_imprinting1.16426128
58MP0001730_embryonic_growth_arrest1.15374643
59MP0004133_heterotaxia1.14134320
60MP0000749_muscle_degeneration1.12757225
61MP0003119_abnormal_digestive_system1.10645487
62MP0006276_abnormal_autonomic_nervous1.08610569
63MP0003646_muscle_fatigue1.08553981
64MP0003136_yellow_coat_color1.08145872
65MP0008775_abnormal_heart_ventricle1.04908942
66MP0003787_abnormal_imprinting1.04848922
67MP0002697_abnormal_eye_size1.03262441
68MP0002938_white_spotting1.01394757
69MP0001119_abnormal_female_reproductive1.01300755
70MP0005389_reproductive_system_phenotype1.01181105
71MP0002132_abnormal_respiratory_system0.99153304
72MP0002160_abnormal_reproductive_system0.97971468
73MP0010030_abnormal_orbit_morphology0.97658669
74MP0000350_abnormal_cell_proliferation0.96865689
75MP0003221_abnormal_cardiomyocyte_apopto0.95825782
76MP0003938_abnormal_ear_development0.95663542
77MP0000313_abnormal_cell_death0.93576598
78MP0006072_abnormal_retinal_apoptosis0.93116818
79MP0005084_abnormal_gallbladder_morpholo0.90881481
80MP0005395_other_phenotype0.90467063
81MP0006035_abnormal_mitochondrial_morpho0.89702437
82MP0005379_endocrine/exocrine_gland_phen0.88826758
83MP0000647_abnormal_sebaceous_gland0.88345755
84MP0001764_abnormal_homeostasis0.88128810
85MP0009672_abnormal_birth_weight0.87450149
86MP0003890_abnormal_embryonic-extraembry0.86035288
87MP0000372_irregular_coat_pigmentation0.84701024
88MP0002090_abnormal_vision0.84568350
89MP0001853_heart_inflammation0.83670926
90MP0003763_abnormal_thymus_physiology0.82195018
91MP0002751_abnormal_autonomic_nervous0.81581547
92MP0001485_abnormal_pinna_reflex0.80937017
93MP0001919_abnormal_reproductive_system0.79039838
94MP0002095_abnormal_skin_pigmentation0.78625157
95MP0003755_abnormal_palate_morphology0.78507712
96MP0001697_abnormal_embryo_size0.78393885
97MP0001672_abnormal_embryogenesis/_devel0.78245625
98MP0005380_embryogenesis_phenotype0.78245625
99MP0001293_anophthalmia0.77435132
100MP0003937_abnormal_limbs/digits/tail_de0.77271654
101MP0008789_abnormal_olfactory_epithelium0.75681858
102MP0005391_vision/eye_phenotype0.75580556
103MP0004197_abnormal_fetal_growth/weight/0.74665691
104MP0001984_abnormal_olfaction0.74360253
105MP0005408_hypopigmentation0.73782737
106MP0000490_abnormal_crypts_of0.73432655
107MP0005253_abnormal_eye_physiology0.73166845
108MP0000049_abnormal_middle_ear0.71713496
109MP0000026_abnormal_inner_ear0.71526854
110MP0002396_abnormal_hematopoietic_system0.70341314
111MP0003137_abnormal_impulse_conducting0.69464180
112MP0005551_abnormal_eye_electrophysiolog0.68135063
113MP0004147_increased_porphyrin_level0.67899914
114MP0002972_abnormal_cardiac_muscle0.67865018
115MP0002085_abnormal_embryonic_tissue0.67307463
116MP0005377_hearing/vestibular/ear_phenot0.66271588
117MP0003878_abnormal_ear_physiology0.66271588
118MP0002111_abnormal_tail_morphology0.66231700
119MP0002080_prenatal_lethality0.65516380
120MP0001727_abnormal_embryo_implantation0.64715709
121MP0000358_abnormal_cell_content/0.64588797
122MP0001186_pigmentation_phenotype0.64377297
123MP0001968_abnormal_touch/_nociception0.64141907
124MP0001286_abnormal_eye_development0.63338030
125MP0005083_abnormal_biliary_tract0.63112421
126MP0000631_abnormal_neuroendocrine_gland0.62914770
127MP0003699_abnormal_female_reproductive0.62302239
128MP0004036_abnormal_muscle_relaxation0.61786059
129MP0009703_decreased_birth_body0.61343866
130MP0004085_abnormal_heartbeat0.61040692
131MP0003984_embryonic_growth_retardation0.59705338
132MP0002019_abnormal_tumor_incidence0.59667740
133MP0009333_abnormal_splenocyte_physiolog0.59455043
134MP0005671_abnormal_response_to0.59368551
135MP0000751_myopathy0.59117519
136MP0005195_abnormal_posterior_eye0.58958389
137MP0004233_abnormal_muscle_weight0.58650919
138MP0005620_abnormal_muscle_contractility0.58240986
139MP0003861_abnormal_nervous_system0.57508764
140MP0005423_abnormal_somatic_nervous0.57442936
141MP0005646_abnormal_pituitary_gland0.55528811
142MP0002088_abnormal_embryonic_growth/wei0.55262099

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.49393062
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.45788882
3Absent/shortened dynein arms (HP:0200106)5.45788882
4Abnormal respiratory epithelium morphology (HP:0012253)4.38823487
5Abnormal respiratory motile cilium morphology (HP:0005938)4.38823487
6Abnormal respiratory motile cilium physiology (HP:0012261)3.86872645
7Birth length less than 3rd percentile (HP:0003561)3.78150533
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.42861489
9Abnormality of alanine metabolism (HP:0010916)3.42861489
10Hyperalaninemia (HP:0003348)3.42861489
11Abnormal ciliary motility (HP:0012262)3.42079827
12Cerebral edema (HP:0002181)3.10232887
13Abnormality of serum amino acid levels (HP:0003112)3.09585573
14Rhinitis (HP:0012384)3.02388491
15Acute necrotizing encephalopathy (HP:0006965)2.96620172
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95481154
17Hepatic necrosis (HP:0002605)2.91935602
18Chronic bronchitis (HP:0004469)2.89577784
19Colon cancer (HP:0003003)2.86757767
20Hypoplasia of the capital femoral epiphysis (HP:0003090)2.82355116
21Medial flaring of the eyebrow (HP:0010747)2.78550163
22Abnormality of the preputium (HP:0100587)2.77961693
23Chromsome breakage (HP:0040012)2.77479297
24Abnormal spermatogenesis (HP:0008669)2.76232295
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74638204
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74638204
27Stenosis of the external auditory canal (HP:0000402)2.73374742
28Methylmalonic acidemia (HP:0002912)2.67365613
29Lipid accumulation in hepatocytes (HP:0006561)2.65154380
30Methylmalonic aciduria (HP:0012120)2.63782725
31Nephronophthisis (HP:0000090)2.63770925
32Septo-optic dysplasia (HP:0100842)2.62264814
333-Methylglutaconic aciduria (HP:0003535)2.59425079
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59125735
35Abnormal mitochondria in muscle tissue (HP:0008316)2.58512203
36Increased serum lactate (HP:0002151)2.58092703
37Breast hypoplasia (HP:0003187)2.55264128
38Lactic acidosis (HP:0003128)2.54809779
39Absent epiphyses (HP:0010577)2.54527930
40Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.54527930
41Pancreatic fibrosis (HP:0100732)2.53187481
42Meckel diverticulum (HP:0002245)2.51936524
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.51662465
44Mitochondrial inheritance (HP:0001427)2.50601888
45Abnormality of methionine metabolism (HP:0010901)2.47322260
46Abnormal lung lobation (HP:0002101)2.41976186
47Abnormality of the ileum (HP:0001549)2.40884919
48Patellar aplasia (HP:0006443)2.40483126
49Reticulocytopenia (HP:0001896)2.40328522
50Abnormality of chromosome stability (HP:0003220)2.39747230
51Cerebral hypomyelination (HP:0006808)2.39040781
52Impulsivity (HP:0100710)2.38820317
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.38639153
54Abnormal protein N-linked glycosylation (HP:0012347)2.38639153
55Abnormal protein glycosylation (HP:0012346)2.38639153
56Abnormal glycosylation (HP:0012345)2.38639153
57Type 2 muscle fiber atrophy (HP:0003554)2.38614218
58Renal Fanconi syndrome (HP:0001994)2.38588469
59Hyperglycinemia (HP:0002154)2.36796526
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.33732586
61Progressive macrocephaly (HP:0004481)2.33137792
62Leukodystrophy (HP:0002415)2.32206901
63Cortical dysplasia (HP:0002539)2.31226993
64Type I transferrin isoform profile (HP:0003642)2.29815045
65Agnosia (HP:0010524)2.29515014
66Spastic diplegia (HP:0001264)2.27506764
67Aplasia/Hypoplasia of the patella (HP:0006498)2.27363766
68Increased CSF lactate (HP:0002490)2.23301682
69Triphalangeal thumb (HP:0001199)2.18733716
70Ependymoma (HP:0002888)2.16792697
71Abnormality of the labia minora (HP:0012880)2.16594396
72Multiple enchondromatosis (HP:0005701)2.16564707
73Exercise intolerance (HP:0003546)2.15449430
74Respiratory failure (HP:0002878)2.15425772
75Pancreatic cysts (HP:0001737)2.15235246
76Hypoplastic pelvis (HP:0008839)2.14055440
77Short tibia (HP:0005736)2.13790653
78Postnatal microcephaly (HP:0005484)2.12758272
79Facial cleft (HP:0002006)2.11581468
80Supernumerary spleens (HP:0009799)2.11473340
81Bone marrow hypocellularity (HP:0005528)2.11019953
82Irregular epiphyses (HP:0010582)2.11005245
83Amniotic constriction ring (HP:0009775)2.09852682
84Abnormality of placental membranes (HP:0011409)2.09852682
85Rough bone trabeculation (HP:0100670)2.09737313
86Duodenal stenosis (HP:0100867)2.09027237
87Small intestinal stenosis (HP:0012848)2.09027237
88Reduced antithrombin III activity (HP:0001976)2.08164507
89Bronchiectasis (HP:0002110)2.05736869
90Nephrogenic diabetes insipidus (HP:0009806)2.05675888
91True hermaphroditism (HP:0010459)2.04302313
92Muscle fiber atrophy (HP:0100295)2.03576929
93Increased hepatocellular lipid droplets (HP:0006565)2.02860265
94Congenital primary aphakia (HP:0007707)2.01395706
95Aplastic anemia (HP:0001915)2.01002134
96Sloping forehead (HP:0000340)1.99994203
97Absent radius (HP:0003974)1.98455160
98Abnormal hair whorl (HP:0010721)1.97719839
99Exertional dyspnea (HP:0002875)1.96958888
100Aplasia involving forearm bones (HP:0009822)1.96910275
101Absent forearm bone (HP:0003953)1.96910275
102Acute encephalopathy (HP:0006846)1.96624915
103Abnormality of cells of the erythroid lineage (HP:0012130)1.96542579
104Absent septum pellucidum (HP:0001331)1.95700578
105Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95018610
106Gait imbalance (HP:0002141)1.95001161
107Molar tooth sign on MRI (HP:0002419)1.94699770
108Abnormality of midbrain morphology (HP:0002418)1.94699770
109Postaxial foot polydactyly (HP:0001830)1.93995143
110Abnormality of the anterior horn cell (HP:0006802)1.93587977
111Degeneration of anterior horn cells (HP:0002398)1.93587977
112Abnormality of glycolysis (HP:0004366)1.93168267
113Increased serum pyruvate (HP:0003542)1.93168267
114Abnormality of the renal medulla (HP:0100957)1.92321055
115Lethargy (HP:0001254)1.91577782
116Adrenal hypoplasia (HP:0000835)1.91279545
117Oral leukoplakia (HP:0002745)1.91131044
118Abnormality of glycine metabolism (HP:0010895)1.90307461
119Abnormality of serine family amino acid metabolism (HP:0010894)1.90307461
120Abnormal number of erythroid precursors (HP:0012131)1.90091646
121Genital tract atresia (HP:0001827)1.89564369
122Duplicated collecting system (HP:0000081)1.88196481
123Ectopic kidney (HP:0000086)1.87463907
124Bifid tongue (HP:0010297)1.87358807
125Hepatocellular necrosis (HP:0001404)1.85844400
126Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85407814
127Vaginal atresia (HP:0000148)1.84926095
128Cleft eyelid (HP:0000625)1.84901398
129CNS demyelination (HP:0007305)1.84003627
130Infertility (HP:0000789)1.82758323
131Poor coordination (HP:0002370)1.81150753
132Microvesicular hepatic steatosis (HP:0001414)1.80109460
133Bronchitis (HP:0012387)1.79602062
134Preaxial hand polydactyly (HP:0001177)1.79463849
135Carpal bone hypoplasia (HP:0001498)1.79393885
136Azoospermia (HP:0000027)1.78892026
137Increased intramyocellular lipid droplets (HP:0012240)1.77890541
138Horseshoe kidney (HP:0000085)1.76761181
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76074829
140Patchy hypopigmentation of hair (HP:0011365)1.75802156
141Abnormality of the septum pellucidum (HP:0007375)1.75754622
142Myelodysplasia (HP:0002863)1.75397714
143Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75227079
144Aplasia/Hypoplasia of the fibula (HP:0006492)1.75092054
145Fibular hypoplasia (HP:0003038)1.74530684
146Absent thumb (HP:0009777)1.73668929
147Fibular aplasia (HP:0002990)1.73627934
148X-linked dominant inheritance (HP:0001423)1.73134592
149Tubulointerstitial nephritis (HP:0001970)1.72141304
150Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71683887
151Secondary amenorrhea (HP:0000869)1.71056366
152Gonadotropin excess (HP:0000837)1.70594058
153Premature graying of hair (HP:0002216)1.69578971
154Optic disc pallor (HP:0000543)1.69462402
155Optic nerve hypoplasia (HP:0000609)1.69110714
156Abnormality of the duodenum (HP:0002246)1.68923384
157Hypoglycemic coma (HP:0001325)1.68324640
158Pendular nystagmus (HP:0012043)1.68026230
159Cellular immunodeficiency (HP:0005374)1.67914269
160Medulloblastoma (HP:0002885)1.67887147
161Palpitations (HP:0001962)1.67202676
162Embryonal renal neoplasm (HP:0011794)1.66677220
163Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66420477
164Megaloblastic anemia (HP:0001889)1.65862775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.41294570
2BUB13.38839035
3STK162.98973357
4NEK12.79902504
5PLK42.68899390
6WEE12.55921510
7EIF2AK32.49807833
8SRPK12.43338300
9PDK32.38534247
10PDK42.38534247
11AKT32.37548882
12TRIM282.26727528
13VRK22.22078950
14TESK22.07254511
15ZAK2.03293595
16PDK21.90852127
17PBK1.81474501
18CASK1.79727539
19MKNK21.76235370
20CCNB11.75932943
21VRK11.74815211
22WNK31.71906010
23BRAF1.70962332
24MKNK11.70515197
25NME11.66419263
26NME21.65464087
27TESK11.63623398
28STK38L1.56999161
29BMPR1B1.56956932
30DYRK31.54976785
31DYRK21.48035692
32CDC71.42895175
33PLK11.42828810
34TTK1.41584775
35TIE11.41286366
36MST41.33357195
37BCR1.28491654
38PLK31.28011781
39TNIK1.22274800
40TXK1.21969071
41EIF2AK21.21585162
42CDK81.21098306
43BRSK21.20627134
44TSSK61.20097655
45SIK31.18965293
46NEK21.16000797
47CHEK21.14900075
48MAP4K21.14774800
49ATR1.13863772
50YES11.13646286
51MAP2K71.10702248
52CSNK1G11.06244222
53RPS6KA41.04040258
54ERBB41.04004398
55ACVR1B1.03568279
56CDK70.97668075
57PNCK0.96612805
58AURKB0.94487540
59PAK40.93682147
60TLK10.93029625
61AURKA0.92772198
62CSNK1G30.92672396
63MAP3K40.89588895
64EPHA20.89571923
65CSNK1G20.89457205
66ARAF0.89093045
67LIMK10.88109811
68BMPR20.87614458
69NEK60.86925210
70BCKDK0.83298718
71MYLK0.81807120
72BRSK10.80428057
73CDK30.79891473
74MAPK130.76522159
75NUAK10.75429844
76ERBB30.75042525
77IRAK40.74629692
78IRAK20.71280171
79MAP3K120.70736843
80PASK0.70195998
81IRAK30.69583058
82PLK20.69206527
83STK240.66152008
84TAF10.66068306
85MAP3K50.65016629
86CHEK10.62799728
87CSNK2A10.58545531
88NLK0.57669928
89MUSK0.55965941
90STK100.54698491
91KDR0.54273700
92CSNK1A1L0.53718789
93STK390.53610592
94ADRBK20.52620544
95MINK10.52207859
96ALK0.51572647
97RPS6KA50.51339299
98PAK30.51138863
99CDK190.51049877
100ATM0.50190853
101TGFBR10.49900381
102IRAK10.45346866
103CLK10.44995881
104DYRK1A0.44935971
105MAP3K140.44923552
106STK30.43769843
107PAK10.41830333
108PRKCE0.41255682
109CSNK2A20.41186492
110MARK30.40799361
111EPHA40.39940838
112CDK140.35449713
113MAP3K80.35192175
114CSNK1E0.35057268
115BRD40.34249892
116CDK10.34088040
117CAMK2B0.33592350
118CDK180.32924188
119PRPF4B0.32273946
120NEK90.31040777
121MET0.30494564
122OBSCN0.30378100
123SGK20.30099877
124OXSR10.30017973
125CDK20.29540037
126STK40.29243369
127PIM20.28960721
128MARK10.28467854
129GRK10.27880969
130MELK0.27122022
131FGR0.26860747
132PRKCG0.25971299
133CDK90.25950474
134PRKCI0.25449389

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28599382
2RNA polymerase_Homo sapiens_hsa030203.62841046
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22782988
4Basal transcription factors_Homo sapiens_hsa030223.05375883
5Homologous recombination_Homo sapiens_hsa034403.01419074
6DNA replication_Homo sapiens_hsa030302.90342908
7Mismatch repair_Homo sapiens_hsa034302.87662893
8Ribosome_Homo sapiens_hsa030102.84365349
9Fanconi anemia pathway_Homo sapiens_hsa034602.79294910
10Spliceosome_Homo sapiens_hsa030402.69650089
11RNA transport_Homo sapiens_hsa030132.47491292
12Nucleotide excision repair_Homo sapiens_hsa034202.42054852
13Protein export_Homo sapiens_hsa030602.38584691
14Pyrimidine metabolism_Homo sapiens_hsa002402.26877882
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03102615
16Base excision repair_Homo sapiens_hsa034101.99308571
17Cell cycle_Homo sapiens_hsa041101.98996172
18RNA degradation_Homo sapiens_hsa030181.89737501
19Oxidative phosphorylation_Homo sapiens_hsa001901.83599861
20Non-homologous end-joining_Homo sapiens_hsa034501.83483674
21Huntingtons disease_Homo sapiens_hsa050161.82325234
22Fatty acid elongation_Homo sapiens_hsa000621.82309380
23Propanoate metabolism_Homo sapiens_hsa006401.71832982
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69063367
25Purine metabolism_Homo sapiens_hsa002301.67731497
26Vitamin B6 metabolism_Homo sapiens_hsa007501.52741092
27Parkinsons disease_Homo sapiens_hsa050121.52341412
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51383510
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49672796
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49316622
31Pyruvate metabolism_Homo sapiens_hsa006201.48992463
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44927086
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38317514
34mRNA surveillance pathway_Homo sapiens_hsa030151.38106700
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37592577
36Folate biosynthesis_Homo sapiens_hsa007901.35316781
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22547325
38Epstein-Barr virus infection_Homo sapiens_hsa051691.17973040
39p53 signaling pathway_Homo sapiens_hsa041151.09421559
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09101694
41Regulation of autophagy_Homo sapiens_hsa041401.04332940
42Carbon metabolism_Homo sapiens_hsa012001.02159854
43Biosynthesis of amino acids_Homo sapiens_hsa012301.01692948
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98378151
45Alzheimers disease_Homo sapiens_hsa050100.97759579
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93087397
47Sulfur metabolism_Homo sapiens_hsa009200.89739593
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86005032
49Asthma_Homo sapiens_hsa053100.85287829
50Arachidonic acid metabolism_Homo sapiens_hsa005900.85010223
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84010265
52Sphingolipid metabolism_Homo sapiens_hsa006000.79638966
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78613385
54Oocyte meiosis_Homo sapiens_hsa041140.78455268
55Peroxisome_Homo sapiens_hsa041460.76307179
56Ether lipid metabolism_Homo sapiens_hsa005650.75557903
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74663400
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72038678
59Linoleic acid metabolism_Homo sapiens_hsa005910.72024994
60Collecting duct acid secretion_Homo sapiens_hsa049660.71610495
61One carbon pool by folate_Homo sapiens_hsa006700.71025038
62Autoimmune thyroid disease_Homo sapiens_hsa053200.70584041
63Herpes simplex infection_Homo sapiens_hsa051680.70297638
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69807424
65Primary immunodeficiency_Homo sapiens_hsa053400.67940247
66Allograft rejection_Homo sapiens_hsa053300.67131854
67Phototransduction_Homo sapiens_hsa047440.66372310
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64126862
69Arginine and proline metabolism_Homo sapiens_hsa003300.60668123
70Hematopoietic cell lineage_Homo sapiens_hsa046400.60507158
71Graft-versus-host disease_Homo sapiens_hsa053320.60085600
72Sulfur relay system_Homo sapiens_hsa041220.59967724
73Systemic lupus erythematosus_Homo sapiens_hsa053220.58372140
74Fatty acid metabolism_Homo sapiens_hsa012120.56744411
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56639483
76Other glycan degradation_Homo sapiens_hsa005110.55962732
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54986966
78Fatty acid degradation_Homo sapiens_hsa000710.53792852
79Antigen processing and presentation_Homo sapiens_hsa046120.52551818
80Butanoate metabolism_Homo sapiens_hsa006500.52333833
81Rheumatoid arthritis_Homo sapiens_hsa053230.51855968
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51467854
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.47776895
84beta-Alanine metabolism_Homo sapiens_hsa004100.46612079
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45918801
86N-Glycan biosynthesis_Homo sapiens_hsa005100.44859701
87Vibrio cholerae infection_Homo sapiens_hsa051100.43700818
88Cardiac muscle contraction_Homo sapiens_hsa042600.43678362
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.41346944
90Caffeine metabolism_Homo sapiens_hsa002320.39331756
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39264771
92Circadian rhythm_Homo sapiens_hsa047100.38663139
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38081186
94Legionellosis_Homo sapiens_hsa051340.37961824
95Metabolic pathways_Homo sapiens_hsa011000.37354622
96Measles_Homo sapiens_hsa051620.37315716
97Tryptophan metabolism_Homo sapiens_hsa003800.37284385
98Viral carcinogenesis_Homo sapiens_hsa052030.37260491
99HTLV-I infection_Homo sapiens_hsa051660.37149163
100Pentose phosphate pathway_Homo sapiens_hsa000300.37038040
101Phagosome_Homo sapiens_hsa041450.35680944
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34878206
103Nicotine addiction_Homo sapiens_hsa050330.33640432
104Steroid biosynthesis_Homo sapiens_hsa001000.33366194
105Glutathione metabolism_Homo sapiens_hsa004800.33333084
106Galactose metabolism_Homo sapiens_hsa000520.31769774
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31699114
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31610607
109Tight junction_Homo sapiens_hsa045300.30167082
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29069663
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28390696
112TGF-beta signaling pathway_Homo sapiens_hsa043500.28139094
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.27803884
114Mineral absorption_Homo sapiens_hsa049780.26858140
115Selenocompound metabolism_Homo sapiens_hsa004500.26762106
116Type I diabetes mellitus_Homo sapiens_hsa049400.25160135
117Shigellosis_Homo sapiens_hsa051310.24970441
118Alcoholism_Homo sapiens_hsa050340.24434923
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.24143239
120Hippo signaling pathway_Homo sapiens_hsa043900.23417745
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22083082
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21976383
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21546515
124Vitamin digestion and absorption_Homo sapiens_hsa049770.20847195
125Basal cell carcinoma_Homo sapiens_hsa052170.20680100
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19879648
127Hedgehog signaling pathway_Homo sapiens_hsa043400.18951187
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18854252
129Renin-angiotensin system_Homo sapiens_hsa046140.18454167
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17728355
131Wnt signaling pathway_Homo sapiens_hsa043100.17198753
132Serotonergic synapse_Homo sapiens_hsa047260.15938680
133Nitrogen metabolism_Homo sapiens_hsa009100.15697535
134Influenza A_Homo sapiens_hsa051640.15659160
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13918647
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13759571
137Colorectal cancer_Homo sapiens_hsa052100.13387118
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.13317994
139Adherens junction_Homo sapiens_hsa045200.12860400
140Starch and sucrose metabolism_Homo sapiens_hsa005000.09249649
141Fat digestion and absorption_Homo sapiens_hsa049750.09091081
142Retinol metabolism_Homo sapiens_hsa008300.08889936
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.08251936

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