FAM118A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.77367624
2regulation of gamma-delta T cell differentiation (GO:0045586)5.31066827
3mitotic metaphase plate congression (GO:0007080)4.98642636
4negative T cell selection (GO:0043383)4.71548343
5regulation of gamma-delta T cell activation (GO:0046643)4.61901065
6erythrocyte development (GO:0048821)4.38743642
7negative thymic T cell selection (GO:0045060)4.35367935
8piRNA metabolic process (GO:0034587)4.26339041
9granulocyte differentiation (GO:0030851)4.24820956
10DNA replication checkpoint (GO:0000076)4.14338448
11positive regulation of granulocyte differentiation (GO:0030854)4.13698824
12embryonic hemopoiesis (GO:0035162)4.09528931
13purine nucleobase biosynthetic process (GO:0009113)4.07746991
14positive T cell selection (GO:0043368)4.06241930
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06100905
16metaphase plate congression (GO:0051310)4.03912787
17positive regulation of B cell differentiation (GO:0045579)4.03184422
18positive regulation of osteoblast proliferation (GO:0033690)4.01847564
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.00867802
20centriole replication (GO:0007099)3.93382098
21positive regulation of erythrocyte differentiation (GO:0045648)3.91419651
22protein K6-linked ubiquitination (GO:0085020)3.90474251
23protein localization to chromosome, centromeric region (GO:0071459)3.89937285
24ribosome biogenesis (GO:0042254)3.87283971
25mucosal-associated lymphoid tissue development (GO:0048537)3.84934469
26Peyers patch development (GO:0048541)3.84934469
27nucleobase biosynthetic process (GO:0046112)3.83022638
28cytidine deamination (GO:0009972)3.81719776
29cytidine metabolic process (GO:0046087)3.81719776
30cytidine catabolic process (GO:0006216)3.81719776
31regulation of B cell receptor signaling pathway (GO:0050855)3.77269111
32establishment of chromosome localization (GO:0051303)3.74460277
33protein localization to kinetochore (GO:0034501)3.71283475
34ribosome assembly (GO:0042255)3.68686642
35oxygen transport (GO:0015671)3.67242376
36DNA methylation involved in gamete generation (GO:0043046)3.66996951
37attachment of spindle microtubules to kinetochore (GO:0008608)3.66028197
38regulation of spindle organization (GO:0090224)3.65552199
39cellular response to thyroid hormone stimulus (GO:0097067)3.65214049
40CENP-A containing nucleosome assembly (GO:0034080)3.60645972
41negative regulation of transcription regulatory region DNA binding (GO:2000678)3.59381484
42chromatin remodeling at centromere (GO:0031055)3.58685209
43T cell selection (GO:0045058)3.58067331
44histone H3-K4 trimethylation (GO:0080182)3.54415981
45histone exchange (GO:0043486)3.54140013
46establishment of protein localization to Golgi (GO:0072600)3.50380640
47kinetochore assembly (GO:0051382)3.49223694
48regulation of B cell differentiation (GO:0045577)3.47571388
49termination of RNA polymerase III transcription (GO:0006386)3.46353370
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.46353370
51thymic T cell selection (GO:0045061)3.45404893
52kinetochore organization (GO:0051383)3.45012591
53positive thymic T cell selection (GO:0045059)3.44364858
547-methylguanosine mRNA capping (GO:0006370)3.44066635
55pyrimidine ribonucleoside catabolic process (GO:0046133)3.42989652
56maturation of 5.8S rRNA (GO:0000460)3.42923578
57mitotic nuclear envelope disassembly (GO:0007077)3.42709759
58synaptonemal complex assembly (GO:0007130)3.39787115
59platelet formation (GO:0030220)3.38854867
60spindle checkpoint (GO:0031577)3.37687687
61rRNA modification (GO:0000154)3.35633753
62DNA replication-independent nucleosome organization (GO:0034724)3.35252270
63DNA replication-independent nucleosome assembly (GO:0006336)3.35252270
64termination of RNA polymerase I transcription (GO:0006363)3.34991920
65synaptonemal complex organization (GO:0070193)3.34195076
667-methylguanosine RNA capping (GO:0009452)3.33603318
67RNA capping (GO:0036260)3.33603318
68nuclear pore organization (GO:0006999)3.33522717
69protein deneddylation (GO:0000338)3.32930587
70cullin deneddylation (GO:0010388)3.32160946
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31589116
72nuclear pore complex assembly (GO:0051292)3.31120634
73negative regulation of bone mineralization (GO:0030502)3.28899792
74regulation of double-strand break repair via homologous recombination (GO:0010569)3.28569199
75regulation of chromosome segregation (GO:0051983)3.28096399
76transcription from RNA polymerase I promoter (GO:0006360)3.26254302
77membrane disassembly (GO:0030397)3.25917179
78nuclear envelope disassembly (GO:0051081)3.25917179
79transcription elongation from RNA polymerase I promoter (GO:0006362)3.24931313
80meiosis I (GO:0007127)3.21616945
81male meiosis I (GO:0007141)3.20960989
82protein targeting to Golgi (GO:0000042)3.20499264
83cellular response to interleukin-15 (GO:0071350)3.20049772
84histone H3-K4 methylation (GO:0051568)3.19702828
85mitotic chromosome condensation (GO:0007076)3.18745624
86regulation of nuclear cell cycle DNA replication (GO:0033262)3.18656168
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18209731
88regulation of regulatory T cell differentiation (GO:0045589)3.18082817
89regulation of histone H3-K4 methylation (GO:0051569)3.17791027
90male meiosis (GO:0007140)3.16956197
91regulation of centrosome cycle (GO:0046605)3.14281122
92mitotic spindle checkpoint (GO:0071174)3.12905893
93positive regulation of chromosome segregation (GO:0051984)3.12427781
94gas transport (GO:0015669)3.12088794
95mitotic sister chromatid segregation (GO:0000070)3.11538107
96regulation of erythrocyte differentiation (GO:0045646)3.10492741
97centriole assembly (GO:0098534)3.09761593
98transcription initiation from RNA polymerase I promoter (GO:0006361)3.09272627
99response to interleukin-15 (GO:0070672)3.09093155
100negative regulation of chromosome segregation (GO:0051985)3.08654796
101proteasome assembly (GO:0043248)3.08483555
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08302475
103spliceosomal snRNP assembly (GO:0000387)3.07896356
104negative regulation of mitotic sister chromatid separation (GO:2000816)3.07041546
105negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07041546
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07041546
107negative regulation of sister chromatid segregation (GO:0033046)3.07041546
108DNA replication initiation (GO:0006270)3.06104169
109meiotic nuclear division (GO:0007126)3.05501713
110microtubule depolymerization (GO:0007019)3.05312217
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04957144
112DNA replication-dependent nucleosome organization (GO:0034723)3.04717872
113DNA replication-dependent nucleosome assembly (GO:0006335)3.04717872
114regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03908486
115formation of translation preinitiation complex (GO:0001731)3.02459534
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02369018
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02276128
118tolerance induction (GO:0002507)3.01492398
119mitotic spindle assembly checkpoint (GO:0007094)3.00363841
120positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.00302954
121transcription elongation from RNA polymerase II promoter (GO:0006368)3.00066382
122DNA-templated transcription, elongation (GO:0006354)2.98247727
123protein localization to chromosome (GO:0034502)2.97516292
124interkinetic nuclear migration (GO:0022027)2.95678492
125regulation of histone H3-K27 methylation (GO:0061085)2.95076612
126spindle assembly checkpoint (GO:0071173)2.95050096
127retrograde transport, vesicle recycling within Golgi (GO:0000301)2.93906121
128regulation of granulocyte differentiation (GO:0030852)2.92779803
129regulation of mitotic spindle organization (GO:0060236)2.92561663
130B cell receptor signaling pathway (GO:0050853)2.91492816
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91426765
132rRNA methylation (GO:0031167)2.90975524
133DNA deamination (GO:0045006)2.90144622
134positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89776755
135regulation of MHC class I biosynthetic process (GO:0045343)2.89450469
136monoubiquitinated protein deubiquitination (GO:0035520)2.89050269
137meiotic cell cycle (GO:0051321)2.88860868
138regulation of cilium movement (GO:0003352)2.88740840
139guanosine-containing compound biosynthetic process (GO:1901070)2.87318022
140regulation of mitotic sister chromatid separation (GO:0010965)2.86707316
141regulation of mitotic sister chromatid segregation (GO:0033047)2.86707316
142regulation of sister chromatid segregation (GO:0033045)2.86707316
143somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86536650
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.86536650
145protein-cofactor linkage (GO:0018065)2.84827351
146regulation of meiosis I (GO:0060631)2.84626357
147DNA strand elongation involved in DNA replication (GO:0006271)2.82338742
148transcription-coupled nucleotide-excision repair (GO:0006283)2.81649072
149respiratory chain complex IV assembly (GO:0008535)2.81399832
150meiotic cell cycle process (GO:1903046)2.80663069
151regulation of centriole replication (GO:0046599)2.80347774
152cilium or flagellum-dependent cell motility (GO:0001539)2.79717007
153regulation of spindle checkpoint (GO:0090231)2.78741928
154G1/S transition of mitotic cell cycle (GO:0000082)2.77975372
155detection of light stimulus involved in sensory perception (GO:0050962)2.76634975
156detection of light stimulus involved in visual perception (GO:0050908)2.76634975
157definitive hemopoiesis (GO:0060216)2.74119486
158DNA methylation (GO:0006306)2.72611089
159DNA alkylation (GO:0006305)2.72611089
160antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72324153
161negative regulation of biomineral tissue development (GO:0070168)2.70700099
162natural killer cell differentiation (GO:0001779)2.69670370
163cellular ketone body metabolic process (GO:0046950)2.69422589
164histone H3-K36 demethylation (GO:0070544)2.68221545
165protein localization to Golgi apparatus (GO:0034067)2.67596131
166rRNA catabolic process (GO:0016075)2.67231377
167protein K11-linked deubiquitination (GO:0035871)2.66614368
168DNA methylation or demethylation (GO:0044728)2.66158491
169negative regulation of T cell mediated immunity (GO:0002710)2.65172162
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63813177
171peptidyl-lysine trimethylation (GO:0018023)2.62452801
172positive regulation of histone deacetylation (GO:0031065)2.61881238
173antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61064305
174histone lysine methylation (GO:0034968)2.60145090
175negative regulation of mast cell activation (GO:0033004)2.56765036
176antigen processing and presentation of endogenous antigen (GO:0019883)2.56455612
177histone H3-K9 methylation (GO:0051567)2.55820749
178regulation of glycoprotein biosynthetic process (GO:0010559)2.54411152
179cell wall macromolecule catabolic process (GO:0016998)2.54078256
180mRNA cleavage (GO:0006379)2.53351122
181positive regulation of defense response to virus by host (GO:0002230)2.52631757
182negative regulation of gluconeogenesis (GO:0045721)2.52284200
183activated T cell proliferation (GO:0050798)2.51640298
184myeloid cell development (GO:0061515)2.50520937
185negative regulation of cell killing (GO:0031342)2.49809476
186negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.49809476
187regulation of alpha-beta T cell proliferation (GO:0046640)2.49357021
188regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.48966675
189response to thyroid hormone (GO:0097066)2.48672873
190gene silencing by RNA (GO:0031047)2.47400508
191regulation of memory T cell differentiation (GO:0043380)2.47016010
192mitochondrial calcium ion transport (GO:0006851)2.46757698
193antigen receptor-mediated signaling pathway (GO:0050851)2.45210939
194valine metabolic process (GO:0006573)2.44818491
195protein K63-linked deubiquitination (GO:0070536)2.44511434
196T cell migration (GO:0072678)2.44442753
197S-adenosylmethionine metabolic process (GO:0046500)2.43917126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87428130
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.32379883
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.72017616
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70920957
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.66008893
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.52479599
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49393441
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.37824080
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34231394
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27199145
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21929743
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.21857301
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17643203
14ZNF274_21170338_ChIP-Seq_K562_Hela3.14681854
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99497893
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.96106625
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88131369
18GATA1_22025678_ChIP-Seq_K562_Human2.73691940
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67707220
20RUNX_20019798_ChIP-Seq_JUKART_Human2.59682032
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58604568
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51682271
23VDR_22108803_ChIP-Seq_LS180_Human2.50889666
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50231301
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49885244
26VDR_23849224_ChIP-Seq_CD4+_Human2.43294343
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42821310
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.41428986
29MYB_26560356_Chip-Seq_TH2_Human2.38010422
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33691684
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30677021
32AR_21909140_ChIP-Seq_LNCAP_Human2.26957755
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26596093
34MYCN_18555785_ChIP-Seq_MESCs_Mouse2.22778995
35* GATA1_19941826_ChIP-Seq_K562_Human2.14694308
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13194222
37GABP_19822575_ChIP-Seq_HepG2_Human2.11462916
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.10115461
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06998012
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05455371
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05057554
42SCL_19346495_ChIP-Seq_HPC-7_Human2.04945652
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04521696
44SALL1_21062744_ChIP-ChIP_HESCs_Human2.02123999
45XRN2_22483619_ChIP-Seq_HELA_Human1.96057422
46DCP1A_22483619_ChIP-Seq_HELA_Human1.93497087
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92291936
48GATA3_27048872_Chip-Seq_THYMUS_Human1.89504918
49ELK1_19687146_ChIP-ChIP_HELA_Human1.87429155
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86499268
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83210843
52FOXP3_21729870_ChIP-Seq_TREG_Human1.82242215
53* MYB_26560356_Chip-Seq_TH1_Human1.80398134
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77349748
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76058011
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.75239433
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.74411751
58* GATA3_26560356_Chip-Seq_TH2_Human1.74165480
59TTF2_22483619_ChIP-Seq_HELA_Human1.73996614
60* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.73989908
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72170362
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71816089
63SPI1_23127762_ChIP-Seq_K562_Human1.71182705
64* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69819827
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.69382559
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69023746
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.62914785
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62215280
69* GATA2_19941826_ChIP-Seq_K562_Human1.61643006
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60148686
71ER_23166858_ChIP-Seq_MCF-7_Human1.58726909
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56190743
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.54416119
74* KDM5A_27292631_Chip-Seq_BREAST_Human1.54386703
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49405965
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.46281394
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43778842
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42412043
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41729860
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41186094
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40776285
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40583287
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39622499
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.38935046
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.38524198
86AR_21572438_ChIP-Seq_LNCaP_Human1.38485667
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38019007
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.35880710
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33759351
90EZH2_22144423_ChIP-Seq_EOC_Human1.33142646
91IRF1_19129219_ChIP-ChIP_H3396_Human1.31774860
92NCOR1_26117541_ChIP-Seq_K562_Human1.31146422
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30793664
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30632131
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29565261
96CIITA_25753668_ChIP-Seq_RAJI_Human1.28304498
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28059861
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27265393
99BCAT_22108803_ChIP-Seq_LS180_Human1.26938369
100UTX_26944678_Chip-Seq_JUKART_Human1.26864623
101MAF_26560356_Chip-Seq_TH2_Human1.25040053
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23068022
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22977908
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.22526679
105SMRT_27268052_Chip-Seq_Bcells_Human1.21241749
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20633415
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20583170
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20565488
109* SPI1_23547873_ChIP-Seq_NB4_Human1.18718316
110TFEB_21752829_ChIP-Seq_HELA_Human1.18421232
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17819116
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17369409
113MAF_26560356_Chip-Seq_TH1_Human1.17003642
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15696228
115OCT4_20526341_ChIP-Seq_ESCs_Human1.14324837
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14128285
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13400115
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12755456
119NANOG_21062744_ChIP-ChIP_HESCs_Human1.12205214
120GATA3_21878914_ChIP-Seq_MCF-7_Human1.11317286
121SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10662428
122PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10448135
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10443633
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10206563
125GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10035576
126TP53_22573176_ChIP-Seq_HFKS_Human1.09536972
127GATA3_26560356_Chip-Seq_TH1_Human1.09513215
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09410377
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09051606
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08086736
131FLI1_27457419_Chip-Seq_LIVER_Mouse1.08054559
132* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07814081
133P300_27268052_Chip-Seq_Bcells_Human1.07528486
134EWS_26573619_Chip-Seq_HEK293_Human1.07148952
135WDR5_24793694_ChIP-Seq_LNCAP_Human1.06592028
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05845628
137ERA_21632823_ChIP-Seq_H3396_Human1.05437463
138FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04973099
139FOXA1_25329375_ChIP-Seq_VCAP_Human1.04973099
140IRF8_27001747_Chip-Seq_BMDM_Mouse1.04452599
141FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03851812
142* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03469144
143TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03431357
144GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03387636
145DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03384398
146KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02588716
147* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02363894
148TCF4_23295773_ChIP-Seq_U87_Human1.01780615
149HOXB7_26014856_ChIP-Seq_BT474_Human1.01188836
150TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01049969
151POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00712397
152HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00694677
153DROSHA_22980978_ChIP-Seq_HELA_Human1.00408807
154ETV1_20927104_ChIP-Seq_GIST48_Human0.99429349
155ELK1_22589737_ChIP-Seq_MCF10A_Human0.99099524
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95706957
157EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95582408
158PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94769084
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94553419
160NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93443909
161STAT3_23295773_ChIP-Seq_U87_Human0.93007691
162GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92759263
163BP1_19119308_ChIP-ChIP_Hs578T_Human0.92376203
164EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91839104
165RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91568519
166CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90104696
167MYC_18940864_ChIP-ChIP_HL60_Human0.89119280
168CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89004122
169TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88691288
170SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88099967
171ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87866156
172NFYB_21822215_ChIP-Seq_K562_Human0.87831905
173NANOG_20526341_ChIP-Seq_ESCs_Human0.87108405
174FOXH1_21741376_ChIP-Seq_ESCs_Human0.86955925
175E2F1_17053090_ChIP-ChIP_MCF-7_Human0.86491814
176MYC_22102868_ChIP-Seq_BL_Human0.86394497
177* RAC3_21632823_ChIP-Seq_H3396_Human0.86368953
178ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85400569
179STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84480801
180KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84151750
181KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84151750
182KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84151750
183FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77198069
184NANOG_16153702_ChIP-ChIP_HESCs_Human0.76858342
185KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76539335
186CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74834891
187ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.74717847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.73343196
2MP0002132_abnormal_respiratory_system5.21607290
3MP0003111_abnormal_nucleus_morphology4.16092405
4MP0010094_abnormal_chromosome_stability3.97975793
5MP0004957_abnormal_blastocyst_morpholog3.84864446
6MP0008057_abnormal_DNA_replication3.84611588
7MP0008877_abnormal_DNA_methylation3.68833634
8MP0003077_abnormal_cell_cycle3.52196298
9MP0008058_abnormal_DNA_repair3.30538404
10MP0004147_increased_porphyrin_level3.14957272
11MP0003718_maternal_effect2.86126996
12MP0008007_abnormal_cellular_replicative2.71012973
13MP0003786_premature_aging2.63586067
14MP0001873_stomach_inflammation2.39720221
15MP0005671_abnormal_response_to2.39645194
16MP0001661_extended_life_span2.29546283
17MP0008932_abnormal_embryonic_tissue2.28968080
18MP0001929_abnormal_gametogenesis2.26095514
19MP0003123_paternal_imprinting2.25794562
20MP0005397_hematopoietic_system_phenotyp2.25378230
21MP0001545_abnormal_hematopoietic_system2.25378230
22MP0005410_abnormal_fertilization2.23773098
23MP0002210_abnormal_sex_determination2.14851074
24MP0008872_abnormal_physiological_respon2.13312795
25MP0001835_abnormal_antigen_presentation2.10691222
26MP0001730_embryonic_growth_arrest2.10091012
27MP0000685_abnormal_immune_system2.06605494
28MP0000372_irregular_coat_pigmentation2.00997093
29MP0001800_abnormal_humoral_immune1.96990997
30MP0000350_abnormal_cell_proliferation1.92418625
31MP0003656_abnormal_erythrocyte_physiolo1.84116699
32MP0000703_abnormal_thymus_morphology1.83608954
33MP0001145_abnormal_male_reproductive1.80199493
34MP0003646_muscle_fatigue1.75093669
35MP0003121_genomic_imprinting1.73079766
36MP0003698_abnormal_male_reproductive1.71177608
37MP0006292_abnormal_olfactory_placode1.69710211
38MP0002398_abnormal_bone_marrow1.69585173
39MP0002160_abnormal_reproductive_system1.67680853
40MP0000653_abnormal_sex_gland1.67612921
41MP0001188_hyperpigmentation1.67254052
42MP0005380_embryogenesis_phenotype1.66672077
43MP0001672_abnormal_embryogenesis/_devel1.66672077
44MP0008961_abnormal_basal_metabolism1.66263021
45MP0010307_abnormal_tumor_latency1.66203360
46MP0003436_decreased_susceptibility_to1.64743963
47MP0003315_abnormal_perineum_morphology1.63605616
48MP0002723_abnormal_immune_serum1.63543067
49MP0005636_abnormal_mineral_homeostasis1.60287576
50MP0004145_abnormal_muscle_electrophysio1.59131918
51MP0001697_abnormal_embryo_size1.57245822
52MP0001764_abnormal_homeostasis1.56175051
53MP0005000_abnormal_immune_tolerance1.55574246
54MP0006036_abnormal_mitochondrial_physio1.54711239
55MP0001790_abnormal_immune_system1.50944639
56MP0005387_immune_system_phenotype1.50944639
57MP0002722_abnormal_immune_system1.50624993
58MP0002420_abnormal_adaptive_immunity1.49869611
59MP0000716_abnormal_immune_system1.49464073
60MP0000689_abnormal_spleen_morphology1.49368931
61MP0005389_reproductive_system_phenotype1.47470797
62MP0005075_abnormal_melanosome_morpholog1.46898353
63MP0005360_urolithiasis1.46073186
64MP0001819_abnormal_immune_cell1.45863548
65MP0002138_abnormal_hepatobiliary_system1.45764187
66MP0005645_abnormal_hypothalamus_physiol1.45617596
67MP0002877_abnormal_melanocyte_morpholog1.44860839
68MP0002085_abnormal_embryonic_tissue1.44381699
69MP0002084_abnormal_developmental_patter1.40700028
70MP0003984_embryonic_growth_retardation1.38201571
71MP0001986_abnormal_taste_sensitivity1.37911917
72MP0002452_abnormal_antigen_presenting1.35987732
73MP0002277_abnormal_respiratory_mucosa1.34810060
74MP0002088_abnormal_embryonic_growth/wei1.34538303
75MP0002080_prenatal_lethality1.34224573
76MP0003787_abnormal_imprinting1.29835385
77MP0000015_abnormal_ear_pigmentation1.28069585
78MP0005025_abnormal_response_to1.26741645
79MP0001119_abnormal_female_reproductive1.26026119
80MP0001919_abnormal_reproductive_system1.25064954
81MP0002429_abnormal_blood_cell1.20969438
82MP0002161_abnormal_fertility/fecundity1.20856361
83MP0002163_abnormal_gland_morphology1.20534955
84MP0003195_calcinosis1.17665088
85MP0002405_respiratory_system_inflammati1.17045495
86MP0003866_abnormal_defecation1.16979473
87MP0010155_abnormal_intestine_physiology1.16536027
88MP0000313_abnormal_cell_death1.15103807
89MP0003172_abnormal_lysosome_physiology1.14588264
90MP0008995_early_reproductive_senescence1.14507297
91MP0003119_abnormal_digestive_system1.12842805
92MP0002396_abnormal_hematopoietic_system1.12502827
93MP0006082_CNS_inflammation1.10981471
94MP0005646_abnormal_pituitary_gland1.10423371
95MP0004043_abnormal_pH_regulation1.09389170
96MP0008789_abnormal_olfactory_epithelium1.08082207
97MP0005395_other_phenotype1.07827844
98MP0002086_abnormal_extraembryonic_tissu1.07088704
99MP0003890_abnormal_embryonic-extraembry1.06994403
100MP0001293_anophthalmia1.06957301
101MP0002933_joint_inflammation1.06308983
102MP0002938_white_spotting1.06020762
103MP0010030_abnormal_orbit_morphology1.05721519
104MP0002009_preneoplasia1.04819370
105MP0003937_abnormal_limbs/digits/tail_de1.04559497
106MP0002638_abnormal_pupillary_reflex1.04436514
107MP0002653_abnormal_ependyma_morphology1.03616024
108MP0001485_abnormal_pinna_reflex1.03411729
109MP0004133_heterotaxia1.02172712
110MP0000678_abnormal_parathyroid_gland0.99833006
111MP0005408_hypopigmentation0.99601003
112MP0004808_abnormal_hematopoietic_stem0.98971405
113MP0009333_abnormal_splenocyte_physiolog0.96129439
114MP0006072_abnormal_retinal_apoptosis0.95738918
115MP0009115_abnormal_fat_cell0.95065087
116MP0009785_altered_susceptibility_to0.94650905
117MP0005451_abnormal_body_composition0.94642599
118MP0000358_abnormal_cell_content/0.92660149
119MP0002419_abnormal_innate_immunity0.91411267
120MP0006035_abnormal_mitochondrial_morpho0.91359849
121MP0002693_abnormal_pancreas_physiology0.91072170
122MP0004233_abnormal_muscle_weight0.91024786
123MP0004381_abnormal_hair_follicle0.88712046
124MP0003221_abnormal_cardiomyocyte_apopto0.87616337
125MP0004885_abnormal_endolymph0.87449003
126MP0003045_fibrosis0.85494533
127MP0003567_abnormal_fetal_cardiomyocyte0.85108504
128MP0001845_abnormal_inflammatory_respons0.84715028
129MP0002166_altered_tumor_susceptibility0.84467386
130MP0001765_abnormal_ion_homeostasis0.83764505
131MP0008875_abnormal_xenobiotic_pharmacok0.82617288
132MP0002928_abnormal_bile_duct0.82092090
133MP0005384_cellular_phenotype0.81885238
134MP0008260_abnormal_autophagy0.80958998
135MP0002019_abnormal_tumor_incidence0.80750686
136MP0003724_increased_susceptibility_to0.80642101
137MP0000516_abnormal_urinary_system0.80012951
138MP0005367_renal/urinary_system_phenotyp0.80012951
139MP0003699_abnormal_female_reproductive0.79359833
140MP0005499_abnormal_olfactory_system0.78049025
141MP0005394_taste/olfaction_phenotype0.78049025
142MP0005551_abnormal_eye_electrophysiolog0.77158756
143MP0005621_abnormal_cell_physiology0.75997351
144MP0003252_abnormal_bile_duct0.74825418
145MP0004197_abnormal_fetal_growth/weight/0.74370851
146MP0005174_abnormal_tail_pigmentation0.73512035
147MP0000490_abnormal_crypts_of0.73357051
148MP0003755_abnormal_palate_morphology0.73100422
149MP0002127_abnormal_cardiovascular_syste0.72689783
150MP0003122_maternal_imprinting0.72268951
151MP0000013_abnormal_adipose_tissue0.72007974
152MP0008469_abnormal_protein_level0.71870380
153MP0010329_abnormal_lipoprotein_level0.71334803
154MP0003861_abnormal_nervous_system0.70920731
155MP0000631_abnormal_neuroendocrine_gland0.70626543
156MP0008775_abnormal_heart_ventricle0.69064361
157MP0010352_gastrointestinal_tract_polyps0.66936770
158MP0003763_abnormal_thymus_physiology0.66321414
159MP0003943_abnormal_hepatobiliary_system0.66212470
160MP0002233_abnormal_nose_morphology0.65736573
161MP0005083_abnormal_biliary_tract0.65691778
162MP0010386_abnormal_urinary_bladder0.65531886
163MP0000428_abnormal_craniofacial_morphol0.65391703
164MP0002177_abnormal_outer_ear0.64673832
165MP0008770_decreased_survivor_rate0.64494719
166MP0001849_ear_inflammation0.64349268
167MP0003878_abnormal_ear_physiology0.60052447
168MP0005377_hearing/vestibular/ear_phenot0.60052447
169MP0001186_pigmentation_phenotype0.59922531
170MP0002092_abnormal_eye_morphology0.59260387
171MP0005310_abnormal_salivary_gland0.58623491
172MP0000432_abnormal_head_morphology0.57185437
173MP0003115_abnormal_respiratory_system0.56745416
174MP0009703_decreased_birth_body0.56354191
175MP0003935_abnormal_craniofacial_develop0.55357117

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)5.86387947
2Short middle phalanx of the 5th finger (HP:0004220)5.54555769
3Abnormality of the heme biosynthetic pathway (HP:0010472)5.15485729
4Abnormality of the anterior horn cell (HP:0006802)4.56216218
5Degeneration of anterior horn cells (HP:0002398)4.56216218
6Birth length less than 3rd percentile (HP:0003561)4.30046203
7Protruding tongue (HP:0010808)4.12774201
8Poikilocytosis (HP:0004447)3.96296788
9Hypoplastic iliac wings (HP:0002866)3.76863462
10Petechiae (HP:0000967)3.57621966
11Polycythemia (HP:0001901)3.42984344
12Breast hypoplasia (HP:0003187)3.41057336
13Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.40660688
14Pancreatic fibrosis (HP:0100732)3.39697030
15Impulsivity (HP:0100710)3.39572869
16Broad palm (HP:0001169)3.36259851
17Reticulocytosis (HP:0001923)3.35215590
18Short 5th finger (HP:0009237)3.29896533
19Patellar aplasia (HP:0006443)3.29205951
20Aplasia/Hypoplasia of the patella (HP:0006498)3.28859346
21Carpal bone hypoplasia (HP:0001498)3.24747614
22Prolonged bleeding time (HP:0003010)3.19606033
23Pancreatic cysts (HP:0001737)3.10705545
24Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.10294717
25Meckel diverticulum (HP:0002245)3.04564515
26Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.02784567
27Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.02230429
28Abnormality of dental color (HP:0011073)2.95550954
29Atrophy/Degeneration involving motor neurons (HP:0007373)2.94209223
30Cerebral hypomyelination (HP:0006808)2.91295798
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.89109215
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.88403508
33Abnormality of the ileum (HP:0001549)2.88215354
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.85040460
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81388258
36Abnormality of the preputium (HP:0100587)2.81318658
37Supernumerary spleens (HP:0009799)2.79793718
38Abnormality of the phalanges of the 5th finger (HP:0004213)2.78947473
39Male infertility (HP:0003251)2.75709555
40Absent radius (HP:0003974)2.73823104
41Abnormality of chromosome stability (HP:0003220)2.72972684
42Chromsome breakage (HP:0040012)2.70466788
43True hermaphroditism (HP:0010459)2.69115571
44Seborrheic dermatitis (HP:0001051)2.69049850
45Secondary amenorrhea (HP:0000869)2.68938056
46Duplicated collecting system (HP:0000081)2.67924510
47Facial hemangioma (HP:0000329)2.65299440
48Abnormality of the labia minora (HP:0012880)2.62285047
49Abnormality of the renal collecting system (HP:0004742)2.61189362
50Abnormality of T cells (HP:0002843)2.59139295
51Abnormality of the renal cortex (HP:0011035)2.58836502
52Absent forearm bone (HP:0003953)2.58770690
53Aplasia involving forearm bones (HP:0009822)2.58770690
54Autoimmune hemolytic anemia (HP:0001890)2.57967986
55Abnormality of the fingertips (HP:0001211)2.56638704
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.55212787
57Hypoplasia of the fovea (HP:0007750)2.55212787
58Severe visual impairment (HP:0001141)2.54279746
59Molar tooth sign on MRI (HP:0002419)2.53539559
60Abnormality of midbrain morphology (HP:0002418)2.53539559
61Abnormality of T cell physiology (HP:0011840)2.52074416
62Median cleft lip (HP:0000161)2.50725925
63Abnormal respiratory epithelium morphology (HP:0012253)2.49240451
64Abnormal respiratory motile cilium morphology (HP:0005938)2.49240451
65Rhinitis (HP:0012384)2.45860845
66Brushfield spots (HP:0001088)2.44794327
67Hypochromic microcytic anemia (HP:0004840)2.44731503
68Congenital stationary night blindness (HP:0007642)2.44438888
69Facial cleft (HP:0002006)2.44160122
70Capillary hemangiomas (HP:0005306)2.43439719
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.42527752
72Sloping forehead (HP:0000340)2.41017876
73Small intestinal stenosis (HP:0012848)2.40182058
74Duodenal stenosis (HP:0100867)2.40182058
75Recurrent fungal infections (HP:0002841)2.39897912
76Rough bone trabeculation (HP:0100670)2.39072842
77Spinal muscular atrophy (HP:0007269)2.38066896
78Albinism (HP:0001022)2.36365522
79Severe combined immunodeficiency (HP:0004430)2.35723890
80Aplasia/hypoplasia of the humerus (HP:0006507)2.34789539
81Abnormal spermatogenesis (HP:0008669)2.33398713
82Hypochromic anemia (HP:0001931)2.32993329
83Abnormality of reticulocytes (HP:0004312)2.32028033
84Panhypogammaglobulinemia (HP:0003139)2.31854290
85Renal cortical cysts (HP:0000803)2.31267242
86Abnormality of T cell number (HP:0011839)2.31130754
87Infertility (HP:0000789)2.30869139
88Absent/shortened dynein arms (HP:0200106)2.27951831
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.27951831
90Chronic diarrhea (HP:0002028)2.23758018
91Occipital encephalocele (HP:0002085)2.22579026
92Abnormal rod and cone electroretinograms (HP:0008323)2.21483494
93T lymphocytopenia (HP:0005403)2.20344857
94Ileus (HP:0002595)2.18899688
95Stomach cancer (HP:0012126)2.16831992
96Ependymoma (HP:0002888)2.16435620
97Toxemia of pregnancy (HP:0100603)2.15546638
98Abnormal lung lobation (HP:0002101)2.15279673
99Abnormality of DNA repair (HP:0003254)2.14332626
100Neutropenia (HP:0001875)2.13547357
101Chronic mucocutaneous candidiasis (HP:0002728)2.13322370
102Recurrent cutaneous fungal infections (HP:0011370)2.13322370
103Genetic anticipation (HP:0003743)2.13294320
104IgG deficiency (HP:0004315)2.12917990
105Short middle phalanx of finger (HP:0005819)2.12183566
106Delusions (HP:0000746)2.11796269
107Truncus arteriosus (HP:0001660)2.11529848
108Abnormal respiratory motile cilium physiology (HP:0012261)2.10200037
109Large for gestational age (HP:0001520)2.09951106
110Premature ovarian failure (HP:0008209)2.08820703
111Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07657581
112Absent thumb (HP:0009777)2.06690391
113Chronic hepatic failure (HP:0100626)2.05632275
114Short humerus (HP:0005792)2.04744128
115Limb hypertonia (HP:0002509)2.03986530
116Chronic bronchitis (HP:0004469)2.02596203
117Cleft eyelid (HP:0000625)2.02370199
118Hepatocellular necrosis (HP:0001404)2.01407111
119Shawl scrotum (HP:0000049)2.00890309
120Pustule (HP:0200039)2.00390687
121Prominent metopic ridge (HP:0005487)2.00015021
122Hepatic necrosis (HP:0002605)1.99543602
123Anencephaly (HP:0002323)1.99198879
124Nephroblastoma (Wilms tumor) (HP:0002667)1.99067511
125Medulloblastoma (HP:0002885)1.99030142
12611 pairs of ribs (HP:0000878)1.98425096
127Abnormality of the fovea (HP:0000493)1.98159828
128Homocystinuria (HP:0002156)1.97901300
129Abnormality of homocysteine metabolism (HP:0010919)1.97901300
130Entropion (HP:0000621)1.97713391
131Medial flaring of the eyebrow (HP:0010747)1.97366304
132Microretrognathia (HP:0000308)1.96866745
133Squamous cell carcinoma (HP:0002860)1.96407958
134Postnatal microcephaly (HP:0005484)1.96394817
135Selective tooth agenesis (HP:0001592)1.96197887
136Myelodysplasia (HP:0002863)1.96031104
137Bone marrow hypocellularity (HP:0005528)1.95107113
138Abnormality of the umbilical cord (HP:0010881)1.94777809
139Horseshoe kidney (HP:0000085)1.94422117
140Papillary thyroid carcinoma (HP:0002895)1.93717618
141Stomatitis (HP:0010280)1.93404478
142Abnormality of the duodenum (HP:0002246)1.93385217
143Aplastic anemia (HP:0001915)1.91242514
144Personality changes (HP:0000751)1.91160549
145Agnosia (HP:0010524)1.91019167
146Pelvic girdle muscle weakness (HP:0003749)1.90477311
147Slender long bone (HP:0003100)1.89562706
148Tongue fasciculations (HP:0001308)1.89003306
149Abnormality of the wing of the ilium (HP:0011867)1.88972803
150Basal cell carcinoma (HP:0002671)1.88082347
151Abnormality of eosinophils (HP:0001879)1.85681974
152Abnormality of dentin (HP:0010299)1.85617554
153Unsteady gait (HP:0002317)1.84965856
154Elevated erythrocyte sedimentation rate (HP:0003565)1.84858276
155Glioma (HP:0009733)1.84617618
156Shoulder girdle muscle weakness (HP:0003547)1.84219601
157Chronic otitis media (HP:0000389)1.84190509
158Central scotoma (HP:0000603)1.83288432
159Abnormal trabecular bone morphology (HP:0100671)1.83261448
160Premature graying of hair (HP:0002216)1.82527880
161Gastrointestinal infarctions (HP:0005244)1.82385696
162Abnormality of the metopic suture (HP:0005556)1.82343675
163Short thumb (HP:0009778)1.82146645
164Embryonal renal neoplasm (HP:0011794)1.81661065
165CNS hypomyelination (HP:0003429)1.80931947
166Preaxial hand polydactyly (HP:0001177)1.80907878
167Aganglionic megacolon (HP:0002251)1.80851384
168Ectopic kidney (HP:0000086)1.80635227
169Deep palmar crease (HP:0006191)1.79315636
170Macroglossia (HP:0000158)1.78958810
171Abnormality of transition element cation homeostasis (HP:0011030)1.78700921
172Rhabdomyosarcoma (HP:0002859)1.78315326
173Abnormal number of erythroid precursors (HP:0012131)1.77503367
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.77105492
175Cystic liver disease (HP:0006706)1.76931542
176Aplasia/Hypoplasia of the macula (HP:0008059)1.76665220
177Attenuation of retinal blood vessels (HP:0007843)1.76507030
178Abnormal platelet function (HP:0011869)1.76381170
179Impaired platelet aggregation (HP:0003540)1.76381170
180Hypoplastic ilia (HP:0000946)1.74147388
181Encephalitis (HP:0002383)1.74039488
182Eczematoid dermatitis (HP:0000976)1.71713742
183Complete atrioventricular canal defect (HP:0001674)1.71556032
184Microtia (HP:0008551)1.71065395
185Cerebral palsy (HP:0100021)1.68389774
186Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67749141
187Progressive cerebellar ataxia (HP:0002073)1.67336935
188Gaze-evoked nystagmus (HP:0000640)1.67334270
189Recurrent viral infections (HP:0004429)1.67123258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.71580993
2CDK124.18435709
3WEE13.95003164
4CDC73.72353155
5FRK3.69430496
6PLK43.01104581
7BRSK22.86051032
8SRPK12.85540811
9MAP4K12.85475799
10AKT32.74340722
11NEK22.65247059
12EIF2AK12.51617573
13TXK2.51133496
14ERN12.39391337
15TTK2.37784250
16ITK2.35532324
17TAOK32.35328683
18RIPK42.30797798
19STK38L2.30067498
20TNK22.25032279
21MAP3K72.24313962
22PLK32.18038584
23EIF2AK32.16178064
24WNK42.15352056
25PLK12.13122586
26LATS22.09111553
27PDK31.98657839
28PDK41.98657839
29CHEK21.98649057
30BRSK11.94112125
31TRPM71.92805765
32TESK11.82170999
33DYRK31.82152873
34MAPKAPK31.75964267
35TEC1.75435277
36BRAF1.69413491
37ADRBK21.67820634
38EEF2K1.62142131
39BRD41.61217921
40PRKD31.56963326
41ACVR1B1.56483041
42TYK21.56442303
43BTK1.56348623
44AURKB1.46976466
45ZAK1.46139743
46CDK81.43378113
47TSSK61.36845036
48JAK31.36212267
49MST41.34516452
50AURKA1.34147824
51BMPR21.33974938
52ATR1.28793650
53MKNK21.28751793
54MKNK11.26104495
55SYK1.25069637
56PNCK1.21806885
57PDK21.20430385
58VRK11.18709034
59PASK1.18320064
60STK391.17964302
61STK161.16938631
62ZAP701.16288132
63MAPK131.15809003
64MAPK151.14888035
65RAF11.13801633
66EPHA21.13481860
67FGFR41.12905119
68BLK1.10379379
69PLK21.07161646
70OXSR11.06805763
71NEK11.06289386
72PRKCQ1.06056978
73ARAF1.05379010
74EPHA31.05273066
75IKBKB1.04840293
76OBSCN1.04689578
77CDK71.04554285
78FGFR21.04291486
79CHEK11.02995639
80IRAK11.02588261
81FES1.02289519
82NLK1.00542281
83MAP3K100.99018261
84RPS6KA40.98651902
85NME20.97244199
86PRKCI0.96987761
87LCK0.93716663
88MELK0.92770350
89DYRK20.92524505
90CCNB10.92064718
91FGFR30.92046006
92STK30.88065621
93TESK20.85473039
94SIK20.84237424
95ATM0.83649496
96PRKAA20.82603034
97IRAK40.79871451
98GRK10.77916561
99LYN0.76976851
100MAP3K140.76356570
101NTRK30.75124981
102ERBB30.74680551
103GRK60.72610454
104CDK40.72453218
105CDK20.71704614
106MAP4K20.71678408
107INSRR0.70493060
108JAK20.70465164
109PTK2B0.70185014
110MAPK110.69804029
111KIT0.69195105
112IKBKE0.68900985
113CSK0.66775898
114NME10.66711333
115HCK0.66235976
116EIF2AK20.64125971
117TNIK0.62756392
118EPHB10.61621838
119LATS10.60106811
120CSNK2A10.59555169
121PAK10.59118061
122JAK10.58912422
123PIM20.58467708
124ERBB20.58325982
125MAP3K80.57345366
126CHUK0.55845238
127CDK10.55538948
128MAPK30.55412668
129PIK3CA0.53862059
130CDK30.53363947
131PRKAA10.53092419
132CDC42BPA0.52979780
133MAP3K60.52403266
134STK380.52237925
135PRKD10.51984494
136CSNK2A20.51280389
137MARK30.49340114
138HIPK20.48620886
139PDK10.48339728
140MAP3K50.47196960
141MAP2K60.46665221
142YES10.45991659
143LIMK10.45051565
144RET0.44755399
145CLK10.44686182
146CSF1R0.44453633
147IRAK20.42353033
148WNK10.41920141
149MAPK120.41732739
150BCR0.40835356
151AKT10.40121442
152MAP3K130.39710564
153MAPK70.39500520
154MARK20.38535341
155STK240.38445409
156WNK30.38185349
157MAPK10.37928963
158MAP3K20.36706070
159CAMKK20.36596065
160ALK0.36577906
161SCYL20.36292348
162NEK60.35913198
163NUAK10.33166096
164KDR0.31681600
165RPS6KB20.30153013
166PIM10.29039601
167CSNK1E0.28990953
168KSR10.28503178
169RPS6KB10.28322597
170RPS6KA50.25983488
171STK100.25546261
172PRKDC0.25456885
173PAK30.22816780
174STK40.22499465
175ABL20.21254610
176MOS0.21198588
177MAPK140.21046455
178PRKCG0.18904484
179MAPK90.17867897
180GSK3B0.17608762
181MAPK100.17450170

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.08410394
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.02956877
3Proteasome_Homo sapiens_hsa030503.31050740
4RNA transport_Homo sapiens_hsa030133.28975295
5Basal transcription factors_Homo sapiens_hsa030223.07644824
6DNA replication_Homo sapiens_hsa030303.04370188
7Cell cycle_Homo sapiens_hsa041103.02440388
8Vitamin B6 metabolism_Homo sapiens_hsa007503.00672826
9Mismatch repair_Homo sapiens_hsa034302.93900227
10Spliceosome_Homo sapiens_hsa030402.68457063
11Fanconi anemia pathway_Homo sapiens_hsa034602.65188797
12Homologous recombination_Homo sapiens_hsa034402.63672713
13T cell receptor signaling pathway_Homo sapiens_hsa046602.38727325
14Nucleotide excision repair_Homo sapiens_hsa034202.33577134
15Pyrimidine metabolism_Homo sapiens_hsa002402.25833047
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14995295
17Base excision repair_Homo sapiens_hsa034102.10466846
18RNA degradation_Homo sapiens_hsa030182.09798606
19mRNA surveillance pathway_Homo sapiens_hsa030152.06536196
20Non-homologous end-joining_Homo sapiens_hsa034502.05624847
21Autoimmune thyroid disease_Homo sapiens_hsa053202.04504843
22Graft-versus-host disease_Homo sapiens_hsa053321.91868918
23Oocyte meiosis_Homo sapiens_hsa041141.89168919
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.88778880
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83253322
26Allograft rejection_Homo sapiens_hsa053301.80927858
27p53 signaling pathway_Homo sapiens_hsa041151.78721634
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75090935
29ABC transporters_Homo sapiens_hsa020101.71591065
30Purine metabolism_Homo sapiens_hsa002301.63170456
31Protein export_Homo sapiens_hsa030601.62029831
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59956139
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58896627
34Lysine degradation_Homo sapiens_hsa003101.57108362
35Ether lipid metabolism_Homo sapiens_hsa005651.51744373
36Butanoate metabolism_Homo sapiens_hsa006501.48185099
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42673036
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42389195
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38996962
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36060120
41Hematopoietic cell lineage_Homo sapiens_hsa046401.32299763
42Epstein-Barr virus infection_Homo sapiens_hsa051691.31268682
43Dorso-ventral axis formation_Homo sapiens_hsa043201.28659417
44B cell receptor signaling pathway_Homo sapiens_hsa046621.26924618
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25712075
46Regulation of autophagy_Homo sapiens_hsa041401.22567649
47Glycerolipid metabolism_Homo sapiens_hsa005611.18946475
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18479568
49Ribosome_Homo sapiens_hsa030101.17601878
50Acute myeloid leukemia_Homo sapiens_hsa052211.13855854
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11619782
52Asthma_Homo sapiens_hsa053101.04243071
53Osteoclast differentiation_Homo sapiens_hsa043801.03648566
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.03573611
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01550616
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00365383
57One carbon pool by folate_Homo sapiens_hsa006700.96256554
58Phototransduction_Homo sapiens_hsa047440.93780852
59Propanoate metabolism_Homo sapiens_hsa006400.93110023
60Nitrogen metabolism_Homo sapiens_hsa009100.91922189
61Other glycan degradation_Homo sapiens_hsa005110.91631412
62Leishmaniasis_Homo sapiens_hsa051400.87980865
63Olfactory transduction_Homo sapiens_hsa047400.84704234
64Antigen processing and presentation_Homo sapiens_hsa046120.80929112
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80766852
66Huntingtons disease_Homo sapiens_hsa050160.79094743
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76939166
68Staphylococcus aureus infection_Homo sapiens_hsa051500.76909664
69Viral carcinogenesis_Homo sapiens_hsa052030.75812554
70Mineral absorption_Homo sapiens_hsa049780.75252298
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.75196110
72Thyroid cancer_Homo sapiens_hsa052160.74721809
73Circadian rhythm_Homo sapiens_hsa047100.73207301
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.72938958
75African trypanosomiasis_Homo sapiens_hsa051430.72342497
76Fat digestion and absorption_Homo sapiens_hsa049750.70716717
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70177404
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69422851
79HTLV-I infection_Homo sapiens_hsa051660.69204997
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69170269
81TGF-beta signaling pathway_Homo sapiens_hsa043500.68528434
82Hippo signaling pathway_Homo sapiens_hsa043900.66383370
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.65862708
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64418425
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64145713
86Taste transduction_Homo sapiens_hsa047420.62940480
87Herpes simplex infection_Homo sapiens_hsa051680.62787936
88Choline metabolism in cancer_Homo sapiens_hsa052310.62677243
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62503047
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62327559
91Folate biosynthesis_Homo sapiens_hsa007900.59597874
92Chemical carcinogenesis_Homo sapiens_hsa052040.59481902
93Peroxisome_Homo sapiens_hsa041460.58148705
94Insulin resistance_Homo sapiens_hsa049310.57888863
95Chemokine signaling pathway_Homo sapiens_hsa040620.57259701
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57095568
97TNF signaling pathway_Homo sapiens_hsa046680.57091577
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56989914
99MicroRNAs in cancer_Homo sapiens_hsa052060.56189674
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55707560
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55025344
102Platelet activation_Homo sapiens_hsa046110.54488325
103Calcium signaling pathway_Homo sapiens_hsa040200.54358451
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53834684
105Selenocompound metabolism_Homo sapiens_hsa004500.53490727
106Colorectal cancer_Homo sapiens_hsa052100.52777316
107N-Glycan biosynthesis_Homo sapiens_hsa005100.50888315
108Type II diabetes mellitus_Homo sapiens_hsa049300.49547104
109Influenza A_Homo sapiens_hsa051640.48585489
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47766900
111Fructose and mannose metabolism_Homo sapiens_hsa000510.46785360
112Prostate cancer_Homo sapiens_hsa052150.45901386
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.43267796
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42651102
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.42633682
116Vibrio cholerae infection_Homo sapiens_hsa051100.42434884
117Sphingolipid metabolism_Homo sapiens_hsa006000.42251766
118Tryptophan metabolism_Homo sapiens_hsa003800.42198086
119Amphetamine addiction_Homo sapiens_hsa050310.41689651
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.39917285
121Pentose phosphate pathway_Homo sapiens_hsa000300.39620175
122Serotonergic synapse_Homo sapiens_hsa047260.39583327
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39038171
124Wnt signaling pathway_Homo sapiens_hsa043100.38773885
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.38743925
126Hedgehog signaling pathway_Homo sapiens_hsa043400.38489775
127Insulin secretion_Homo sapiens_hsa049110.37851642
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37684103
129Linoleic acid metabolism_Homo sapiens_hsa005910.35402504
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34993499
131Adherens junction_Homo sapiens_hsa045200.34858378
132Long-term potentiation_Homo sapiens_hsa047200.34255862
133FoxO signaling pathway_Homo sapiens_hsa040680.33736019
134Shigellosis_Homo sapiens_hsa051310.32876394
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31919112
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31865633
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.29073701
138Hepatitis B_Homo sapiens_hsa051610.28686738
139mTOR signaling pathway_Homo sapiens_hsa041500.27998208
140Arachidonic acid metabolism_Homo sapiens_hsa005900.27119119
141Glucagon signaling pathway_Homo sapiens_hsa049220.26021213
142Alcoholism_Homo sapiens_hsa050340.25881821
143Endometrial cancer_Homo sapiens_hsa052130.24484025
144Bladder cancer_Homo sapiens_hsa052190.22897973
145Renin-angiotensin system_Homo sapiens_hsa046140.22720164
146Primary immunodeficiency_Homo sapiens_hsa053400.21289716
147Apoptosis_Homo sapiens_hsa042100.21152529
148Tight junction_Homo sapiens_hsa045300.21147343
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20340682
150Systemic lupus erythematosus_Homo sapiens_hsa053220.20281726
151Small cell lung cancer_Homo sapiens_hsa052220.18454828
152Biosynthesis of amino acids_Homo sapiens_hsa012300.17482321
153HIF-1 signaling pathway_Homo sapiens_hsa040660.17131823
154Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17018121
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16289782
156Pathways in cancer_Homo sapiens_hsa052000.15556642
157Collecting duct acid secretion_Homo sapiens_hsa049660.15333177
158Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14509780
159Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11212305
160Legionellosis_Homo sapiens_hsa051340.10852907
161Vitamin digestion and absorption_Homo sapiens_hsa049770.10638330
162Inositol phosphate metabolism_Homo sapiens_hsa005620.10348917
163alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09938180
164Measles_Homo sapiens_hsa051620.09485198
165Renal cell carcinoma_Homo sapiens_hsa052110.08203309
166Estrogen signaling pathway_Homo sapiens_hsa049150.07802868
167Type I diabetes mellitus_Homo sapiens_hsa049400.07728807
168Metabolic pathways_Homo sapiens_hsa011000.07608021

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