FAM111A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have been associated with Kenny-Caffey syndrome (KCS) type 2 and the more severe osteocraniostenosis (OCS, also known as Gracile Bone Dysplasia), both characterized by short stature, hypoparathyroidism, bone development abnormalities, and hypocalcemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.16176694
2DNA strand elongation involved in DNA replication (GO:0006271)4.94253945
3telomere maintenance via semi-conservative replication (GO:0032201)4.79415951
4DNA strand elongation (GO:0022616)4.72663879
5telomere maintenance via recombination (GO:0000722)4.48676507
6mitotic recombination (GO:0006312)4.39983722
7DNA replication initiation (GO:0006270)4.23608943
8regulation of gamma-delta T cell activation (GO:0046643)4.12526192
9ribosomal small subunit assembly (GO:0000028)4.10425270
10negative regulation of phagocytosis (GO:0050765)4.08696888
11protein localization to kinetochore (GO:0034501)4.03217283
12negative thymic T cell selection (GO:0045060)3.96626025
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.94032393
14negative T cell selection (GO:0043383)3.92654222
15regulation of gamma-delta T cell differentiation (GO:0045586)3.91265134
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.88872542
17negative regulation of cell killing (GO:0031342)3.88872542
18protein localization to chromosome, centromeric region (GO:0071459)3.61339032
19DNA replication checkpoint (GO:0000076)3.59041714
20telomere maintenance via telomere lengthening (GO:0010833)3.58873954
21nucleotide-excision repair, DNA gap filling (GO:0006297)3.58437128
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57911308
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57911308
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55305528
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.55305528
26modulation by symbiont of host immune response (GO:0052553)3.55305528
27positive regulation by symbiont of host defense response (GO:0052509)3.55305528
28modulation by symbiont of host defense response (GO:0052031)3.55305528
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55305528
30regulation of B cell receptor signaling pathway (GO:0050855)3.48855677
31detection of other organism (GO:0098543)3.48640716
32response to type I interferon (GO:0034340)3.47086579
33positive regulation of granulocyte differentiation (GO:0030854)3.46722631
34kinetochore organization (GO:0051383)3.42852349
35cellular response to type I interferon (GO:0071357)3.41020958
36type I interferon signaling pathway (GO:0060337)3.41020958
37antigen processing and presentation of endogenous antigen (GO:0019883)3.40512548
38detection of bacterium (GO:0016045)3.40159894
39T cell migration (GO:0072678)3.40087301
40positive thymic T cell selection (GO:0045059)3.37325727
41mitotic chromosome condensation (GO:0007076)3.36581945
42mitotic sister chromatid cohesion (GO:0007064)3.35837884
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.35396085
44translesion synthesis (GO:0019985)3.29454808
45response to interleukin-15 (GO:0070672)3.26010057
46CENP-A containing nucleosome assembly (GO:0034080)3.23633565
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21559108
48positive regulation of interferon-alpha production (GO:0032727)3.20397742
49regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19748328
50positive regulation of gamma-delta T cell activation (GO:0046645)3.18552457
51macrophage activation involved in immune response (GO:0002281)3.18507946
52response to peptidoglycan (GO:0032494)3.17775791
53attachment of spindle microtubules to kinetochore (GO:0008608)3.17172699
54regulation of DNA endoreduplication (GO:0032875)3.15725715
55nuclear pore complex assembly (GO:0051292)3.12872483
56chromatin remodeling at centromere (GO:0031055)3.11300541
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10536411
58T cell selection (GO:0045058)3.09952776
59DNA topological change (GO:0006265)3.09456350
60meiotic chromosome segregation (GO:0045132)3.09160840
61telomere maintenance (GO:0000723)3.08226619
62regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07635800
63regulation of interferon-alpha production (GO:0032647)3.05916669
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05849799
65positive T cell selection (GO:0043368)3.05424916
66negative regulation of interleukin-12 production (GO:0032695)3.05039904
67positive regulation of B cell differentiation (GO:0045579)3.04808085
68regulation of alpha-beta T cell proliferation (GO:0046640)3.04604313
69telomere organization (GO:0032200)3.04510728
70B cell receptor signaling pathway (GO:0050853)3.02823486
71viral transcription (GO:0019083)3.02073283
72IMP biosynthetic process (GO:0006188)3.01343912
73DNA geometric change (GO:0032392)3.00176400
74DNA duplex unwinding (GO:0032508)3.00027147
75leukocyte aggregation (GO:0070486)2.98719181
76sister chromatid segregation (GO:0000819)2.98216084
77negative regulation of T cell mediated immunity (GO:0002710)2.96480236
78DNA replication-independent nucleosome assembly (GO:0006336)2.95867456
79DNA replication-independent nucleosome organization (GO:0034724)2.95867456
80neutrophil activation involved in immune response (GO:0002283)2.94519339
81dosage compensation (GO:0007549)2.94480562
82translational termination (GO:0006415)2.94101621
83thymic T cell selection (GO:0045061)2.93616522
84detection of external biotic stimulus (GO:0098581)2.93316624
85cellular response to zinc ion (GO:0071294)2.91108041
86mitotic nuclear envelope disassembly (GO:0007077)2.90731114
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.90072025
88interferon-gamma-mediated signaling pathway (GO:0060333)2.88833847
89IMP metabolic process (GO:0046040)2.87871399
90cellular response to interleukin-15 (GO:0071350)2.87250124
91positive regulation of alpha-beta T cell proliferation (GO:0046641)2.84087873
92nuclear pore organization (GO:0006999)2.84061912
93immunoglobulin mediated immune response (GO:0016064)2.83247259
94mitotic sister chromatid segregation (GO:0000070)2.82780336
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82575117
96histone-serine phosphorylation (GO:0035404)2.82009394
97regulation of B cell differentiation (GO:0045577)2.79539086
98negative regulation of lymphocyte mediated immunity (GO:0002707)2.79286525
99defense response to protozoan (GO:0042832)2.77893633
100germinal center formation (GO:0002467)2.77798281
101detection of molecule of bacterial origin (GO:0032490)2.75385882
102definitive hemopoiesis (GO:0060216)2.75060864
103postreplication repair (GO:0006301)2.74396330
104positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74340464
105CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.71292673
106myeloid cell activation involved in immune response (GO:0002275)2.70371169
107regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70325385
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.70318085
109negative regulation of T-helper cell differentiation (GO:0045623)2.70318085
110response to interferon-alpha (GO:0035455)2.70163049
111antigen processing and presentation via MHC class Ib (GO:0002475)2.69773744
112B cell mediated immunity (GO:0019724)2.69513881
113detection of biotic stimulus (GO:0009595)2.69190953
114respiratory burst (GO:0045730)2.69148282
115response to host immune response (GO:0052572)2.69031790
116response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69031790
117regulation of antigen processing and presentation (GO:0002577)2.69004599
118DNA replication-dependent nucleosome assembly (GO:0006335)2.68567401
119DNA replication-dependent nucleosome organization (GO:0034723)2.68567401
120positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68377230
121response to protozoan (GO:0001562)2.68246385
122activated T cell proliferation (GO:0050798)2.68089802
123mature B cell differentiation (GO:0002335)2.67902675
124microglial cell activation (GO:0001774)2.65925385
125nuclear envelope disassembly (GO:0051081)2.65499675
126membrane disassembly (GO:0030397)2.65499675
127negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.63762187
128mismatch repair (GO:0006298)2.63270060
129SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62399392
130hepatocyte apoptotic process (GO:0097284)2.62349130
131dendritic cell migration (GO:0036336)2.61695983
132regulation of tolerance induction (GO:0002643)2.61384134
133response to host (GO:0075136)2.61366896
134response to host defenses (GO:0052200)2.61366896
135response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.61366896
136DNA conformation change (GO:0071103)2.61054146
137translational elongation (GO:0006414)2.60905161
138pore complex assembly (GO:0046931)2.60426281
139response to muramyl dipeptide (GO:0032495)2.58281978
140DNA synthesis involved in DNA repair (GO:0000731)2.58090657
141chromatin assembly or disassembly (GO:0006333)2.57991244
142establishment of chromosome localization (GO:0051303)2.57617534
143ribosomal small subunit biogenesis (GO:0042274)2.57414044
144regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56863140
145maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56855148
146NIK/NF-kappaB signaling (GO:0038061)2.56733270
147regulation of T cell tolerance induction (GO:0002664)2.55545890
148neutrophil mediated immunity (GO:0002446)2.55237325
149negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.54453473
150positive regulation of isotype switching (GO:0045830)2.54316546
151folic acid-containing compound biosynthetic process (GO:0009396)2.54234636
152cotranslational protein targeting to membrane (GO:0006613)2.53838276
153protein targeting to ER (GO:0045047)2.53745731
154regulation of protein heterodimerization activity (GO:0043497)2.53261821
155positive regulation of interferon-beta production (GO:0032728)2.52764576
156positive regulation of antigen processing and presentation (GO:0002579)2.52227402
157neutrophil activation (GO:0042119)2.51053463
158mast cell activation (GO:0045576)2.50755825
159maturation of SSU-rRNA (GO:0030490)2.50298422
160T cell homeostasis (GO:0043029)2.49236914
161nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.49017874
162kinetochore assembly (GO:0051382)2.48502868
163B cell proliferation (GO:0042100)2.48257202
164interferon-gamma production (GO:0032609)2.47325791
1653-UTR-mediated mRNA stabilization (GO:0070935)2.47067088
166dendritic cell chemotaxis (GO:0002407)2.46382121
167cellular extravasation (GO:0045123)2.46330915
168negative regulation of RNA splicing (GO:0033119)2.46048591
169T cell lineage commitment (GO:0002360)2.45043187
170actin nucleation (GO:0045010)2.43229373
171regulation of interferon-beta biosynthetic process (GO:0045357)2.42250511
172angiogenesis involved in wound healing (GO:0060055)2.42193038
173response to fungus (GO:0009620)2.41186931
174establishment of protein localization to endoplasmic reticulum (GO:0072599)2.40635609
175deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.40278727
176base-excision repair (GO:0006284)2.39765634
177negative regulation of B cell proliferation (GO:0030889)2.39441042
178regulation of spindle organization (GO:0090224)2.39181463
179positive regulation of mitotic sister chromatid separation (GO:1901970)2.37832049
180positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.37832049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human4.10223739
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.74083504
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.16419031
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90195304
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74283323
6* IRF8_22096565_ChIP-ChIP_GC-B_Human2.68381768
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.52631150
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51906243
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.50453447
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.41651605
11MYC_22102868_ChIP-Seq_BL_Human2.39402267
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.36418489
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35174403
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27710592
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21189655
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16472176
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.15098630
18VDR_21846776_ChIP-Seq_THP-1_Human2.13941746
19* E2F1_21310950_ChIP-Seq_MCF-7_Human2.11354426
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03918790
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02117389
22E2F7_22180533_ChIP-Seq_HELA_Human10.7361825
23* SPI1_23547873_ChIP-Seq_NB4_Human1.95071763
24SCL_19346495_ChIP-Seq_HPC-7_Human1.92469833
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87341936
26AR_21909140_ChIP-Seq_LNCAP_Human1.81693861
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.79404015
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75320850
29* IRF8_27001747_Chip-Seq_BMDM_Mouse1.71256890
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70384694
31MYB_26560356_Chip-Seq_TH2_Human1.70131743
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70055211
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67554529
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66811745
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66707395
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66699503
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66667412
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66213074
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65590249
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.64957334
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64756966
42* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64087403
43VDR_23849224_ChIP-Seq_CD4+_Human1.62508696
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60813430
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60254219
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57965221
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.56951683
48FOXP3_21729870_ChIP-Seq_TREG_Human1.54633377
49MYB_26560356_Chip-Seq_TH1_Human1.53887701
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53595493
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53343800
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53232871
53VDR_24763502_ChIP-Seq_THP-1_Human1.51484075
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50900060
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.50219544
56* MAF_26560356_Chip-Seq_TH1_Human1.49670276
57GATA3_26560356_Chip-Seq_TH2_Human1.48235876
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.47863945
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46960833
60* ELK1_19687146_ChIP-ChIP_HELA_Human1.46835442
61CIITA_25753668_ChIP-Seq_RAJI_Human1.45721440
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44606315
63XRN2_22483619_ChIP-Seq_HELA_Human1.44486851
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44182715
65VDR_24787735_ChIP-Seq_THP-1_Human1.42668329
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41704081
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39928038
68* UTX_26944678_Chip-Seq_JUKART_Human1.37941497
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37591471
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34603077
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31903788
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29683948
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28563811
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28033885
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.27652373
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26234330
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22570163
78DCP1A_22483619_ChIP-Seq_HELA_Human1.21412485
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19197459
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14879797
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14757330
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.13545012
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13250343
84TCF7_22412390_ChIP-Seq_EML_Mouse1.11760149
85* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11189935
86* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10946951
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10936701
88TTF2_22483619_ChIP-Seq_HELA_Human1.10620370
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10551442
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10309598
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09655815
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08712150
93TFEB_21752829_ChIP-Seq_HELA_Human1.08660144
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07081372
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.06541482
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05730781
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04841808
98* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03819090
99GABP_19822575_ChIP-Seq_HepG2_Human1.03237084
100GATA1_22025678_ChIP-Seq_K562_Human1.02589143
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.01544377
102PU_27001747_Chip-Seq_BMDM_Mouse1.01028115
103KDM5A_27292631_Chip-Seq_BREAST_Human1.00216661
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99440433
105SPI1_23127762_ChIP-Seq_K562_Human0.98540129
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98422792
107ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97725894
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97316120
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95948721
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95948721
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94271996
112* MAF_26560356_Chip-Seq_TH2_Human0.93861628
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.93292393
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92249988
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91001647
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90904871
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89766265
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89311583
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89281776
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88629372
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86454518
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84175797
123RUNX_20019798_ChIP-Seq_JUKART_Human0.83721548
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83193021
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83085527
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.78523698
127SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78434763
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77278427
129* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75954599
130VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75535347
131* GATA6_25053715_ChIP-Seq_YYC3_Human0.75072362
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.74467951
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72422364
134* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71409817
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.71239385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.53884926
2MP0010094_abnormal_chromosome_stability3.29100576
3MP0008057_abnormal_DNA_replication3.24309489
4MP0001835_abnormal_antigen_presentation3.19333976
5MP0003693_abnormal_embryo_hatching2.95854722
6MP0003111_abnormal_nucleus_morphology2.57420065
7MP0004808_abnormal_hematopoietic_stem2.49374384
8MP0003436_decreased_susceptibility_to2.48854556
9MP0003077_abnormal_cell_cycle2.46617144
10MP0001800_abnormal_humoral_immune2.37067764
11MP0003303_peritoneal_inflammation2.25229513
12MP0002166_altered_tumor_susceptibility2.24914875
13MP0002452_abnormal_antigen_presenting2.21082051
14MP0002398_abnormal_bone_marrow2.18172871
15MP0000685_abnormal_immune_system2.14704457
16MP0010307_abnormal_tumor_latency2.09543388
17MP0005000_abnormal_immune_tolerance2.09445192
18MP0002420_abnormal_adaptive_immunity2.08701770
19MP0005671_abnormal_response_to2.08488438
20MP0009785_altered_susceptibility_to2.07538788
21MP0010352_gastrointestinal_tract_polyps2.07111974
22MP0004957_abnormal_blastocyst_morpholog2.05832196
23MP0001819_abnormal_immune_cell2.05422675
24MP0002419_abnormal_innate_immunity2.04647564
25MP0003763_abnormal_thymus_physiology2.04546212
26MP0001545_abnormal_hematopoietic_system1.98525536
27MP0005397_hematopoietic_system_phenotyp1.98525536
28MP0005025_abnormal_response_to1.96049205
29MP0002723_abnormal_immune_serum1.93754868
30MP0005387_immune_system_phenotype1.91526822
31MP0001790_abnormal_immune_system1.91526822
32MP0005464_abnormal_platelet_physiology1.89624226
33MP0000490_abnormal_crypts_of1.88394054
34MP0002006_tumorigenesis1.87276586
35MP0006054_spinal_hemorrhage1.87227471
36MP0000689_abnormal_spleen_morphology1.85099840
37MP0008007_abnormal_cellular_replicative1.85090625
38MP0000716_abnormal_immune_system1.81460180
39MP0003191_abnormal_cellular_cholesterol1.80217008
40MP0002148_abnormal_hypersensitivity_rea1.79505216
41MP0002722_abnormal_immune_system1.77130818
42MP0003300_gastrointestinal_ulcer1.74802791
43MP0002429_abnormal_blood_cell1.68366595
44MP0008058_abnormal_DNA_repair1.66968602
45MP0009333_abnormal_splenocyte_physiolog1.64620384
46MP0002405_respiratory_system_inflammati1.63270547
47MP0000465_gastrointestinal_hemorrhage1.62516311
48MP0005174_abnormal_tail_pigmentation1.61081190
49MP0001853_heart_inflammation1.57394703
50MP0009278_abnormal_bone_marrow1.57062865
51MP0004381_abnormal_hair_follicle1.53849506
52MP0000703_abnormal_thymus_morphology1.51938062
53MP0005310_abnormal_salivary_gland1.46594085
54MP0002019_abnormal_tumor_incidence1.46276969
55MP0000858_altered_metastatic_potential1.45472889
56MP0000569_abnormal_digit_pigmentation1.43903857
57MP0010155_abnormal_intestine_physiology1.39881761
58MP0003806_abnormal_nucleotide_metabolis1.32377523
59MP0000350_abnormal_cell_proliferation1.32194518
60MP0004883_abnormal_blood_vessel1.30221090
61MP0001845_abnormal_inflammatory_respons1.30147350
62MP0001873_stomach_inflammation1.28878696
63MP0003045_fibrosis1.26880530
64MP0002877_abnormal_melanocyte_morpholog1.23450996
65MP0005076_abnormal_cell_differentiation1.22255425
66MP0003448_altered_tumor_morphology1.20466262
67MP0001851_eye_inflammation1.17154094
68MP0008932_abnormal_embryonic_tissue1.16361517
69MP0001533_abnormal_skeleton_physiology1.15526499
70MP0002095_abnormal_skin_pigmentation1.12863784
71MP0003724_increased_susceptibility_to1.11762584
72MP0003566_abnormal_cell_adhesion1.11655335
73MP0004947_skin_inflammation1.10696594
74MP0000313_abnormal_cell_death1.10242883
75MP0005164_abnormal_response_to1.10042773
76MP0003950_abnormal_plasma_membrane1.08535403
77MP0005023_abnormal_wound_healing1.05313652
78MP0002132_abnormal_respiratory_system1.03889511
79MP0000015_abnormal_ear_pigmentation1.02390755
80MP0001730_embryonic_growth_arrest1.02341509
81MP0008877_abnormal_DNA_methylation0.99471191
82MP0004264_abnormal_extraembryonic_tissu0.99144210
83MP0003172_abnormal_lysosome_physiology0.98831415
84MP0002009_preneoplasia0.97406627
85MP0008438_abnormal_cutaneous_collagen0.95844712
86MP0003656_abnormal_erythrocyte_physiolo0.95516110
87MP0000343_altered_response_to0.93340126
88MP0008260_abnormal_autophagy0.89167251
89MP0002933_joint_inflammation0.87668213
90MP0003091_abnormal_cell_migration0.87545593
91MP0003786_premature_aging0.87118460
92MP0003866_abnormal_defecation0.87004304
93MP0000371_diluted_coat_color0.84724925
94MP0008469_abnormal_protein_level0.84696435
95MP0009764_decreased_sensitivity_to0.83586440
96MP0003183_abnormal_peptide_metabolism0.82195528
97MP0002998_abnormal_bone_remodeling0.80855585
98MP0005075_abnormal_melanosome_morpholog0.78768067
99MP0010234_abnormal_vibrissa_follicle0.77884437
100MP0002080_prenatal_lethality0.72224338
101MP0003567_abnormal_fetal_cardiomyocyte0.72169786
102MP0003705_abnormal_hypodermis_morpholog0.72151864
103MP0003828_pulmonary_edema0.71628046
104MP0005408_hypopigmentation0.71257492
105MP0005058_abnormal_lysosome_morphology0.71105801
106MP0001663_abnormal_digestive_system0.69677929
107MP0003984_embryonic_growth_retardation0.69443925
108MP0002086_abnormal_extraembryonic_tissu0.69382074
109MP0001697_abnormal_embryo_size0.69266004
110MP0002088_abnormal_embryonic_growth/wei0.67273028
111MP0001915_intracranial_hemorrhage0.67213379
112MP0005380_embryogenesis_phenotype0.66990241
113MP0001672_abnormal_embryogenesis/_devel0.66990241
114MP0005621_abnormal_cell_physiology0.66859479
115MP0003279_aneurysm0.64546817
116MP0005166_decreased_susceptibility_to0.64188762
117MP0009763_increased_sensitivity_to0.63550353
118MP0004197_abnormal_fetal_growth/weight/0.62924447
119MP0003943_abnormal_hepatobiliary_system0.62200254
120MP0006082_CNS_inflammation0.62132227
121MP0000249_abnormal_blood_vessel0.62031425
122MP0001243_abnormal_dermal_layer0.61641808
123MP0009765_abnormal_xenobiotic_induced0.61140819
124MP0002136_abnormal_kidney_physiology0.60522137

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.55041206
2Thrombocytosis (HP:0001894)4.09143291
3Recurrent bacterial skin infections (HP:0005406)3.96746049
4IgM deficiency (HP:0002850)3.87413307
5Eczematoid dermatitis (HP:0000976)3.69603890
6Cellulitis (HP:0100658)3.61029192
7Recurrent viral infections (HP:0004429)3.53825755
8Autoimmune hemolytic anemia (HP:0001890)3.48915591
9Chromsome breakage (HP:0040012)3.40060696
10Reticulocytopenia (HP:0001896)3.33506476
11Elevated erythrocyte sedimentation rate (HP:0003565)3.22695684
12Retrobulbar optic neuritis (HP:0100654)3.16649848
13Optic neuritis (HP:0100653)3.16649848
14Myositis (HP:0100614)3.03279070
15Chronic otitis media (HP:0000389)3.01931016
16Agnosia (HP:0010524)2.98768322
17Gastrointestinal infarctions (HP:0005244)2.96242477
18Encephalitis (HP:0002383)2.95496485
19Obstructive lung disease (HP:0006536)2.95289197
20Chronic obstructive pulmonary disease (HP:0006510)2.95289197
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93209549
22Recurrent bronchitis (HP:0002837)2.93160847
23Recurrent fungal infections (HP:0002841)2.92504752
24Pulmonary infiltrates (HP:0002113)2.92098420
25Petechiae (HP:0000967)2.90329644
26Abnormality of chromosome stability (HP:0003220)2.88624175
27Meningitis (HP:0001287)2.88358303
28Colitis (HP:0002583)2.88064429
29Mediastinal lymphadenopathy (HP:0100721)2.86984503
30Stomatitis (HP:0010280)2.85045659
31Birth length less than 3rd percentile (HP:0003561)2.76873434
32Chronic diarrhea (HP:0002028)2.74663679
33Abnormal platelet volume (HP:0011876)2.67920055
34Abnormality of T cell physiology (HP:0011840)2.65086465
35Arterial thrombosis (HP:0004420)2.63485663
36Viral hepatitis (HP:0006562)2.63452614
37Abnormality of cells of the erythroid lineage (HP:0012130)2.62859753
38Abnormal number of erythroid precursors (HP:0012131)2.61201473
39Abnormality of the prostate (HP:0008775)2.61180795
40Abnormality of T cells (HP:0002843)2.61036688
41Cutaneous melanoma (HP:0012056)2.60803205
42Lymphoma (HP:0002665)2.60312201
43Aplastic anemia (HP:0001915)2.58293461
44Agammaglobulinemia (HP:0004432)2.56936853
45Myelodysplasia (HP:0002863)2.55988858
46Recurrent skin infections (HP:0001581)2.55957599
47Osteomyelitis (HP:0002754)2.55021055
48Severe combined immunodeficiency (HP:0004430)2.52209631
49Recurrent gram-negative bacterial infections (HP:0005420)2.51575007
50Spontaneous hematomas (HP:0007420)2.50035402
51Lymphopenia (HP:0001888)2.49521968
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.47044590
53Combined immunodeficiency (HP:0005387)2.46334720
54Keratoconjunctivitis sicca (HP:0001097)2.44958651
55Hemoptysis (HP:0002105)2.42483417
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.42035857
57B lymphocytopenia (HP:0010976)2.41101174
58Abnormality of B cell number (HP:0010975)2.41101174
59Volvulus (HP:0002580)2.40490906
60Prolonged bleeding time (HP:0003010)2.40228089
61Prostate neoplasm (HP:0100787)2.39711797
62Increased IgE level (HP:0003212)2.33394563
63Spinal cord lesions (HP:0100561)2.33300962
64Syringomyelia (HP:0003396)2.33300962
65T lymphocytopenia (HP:0005403)2.32725635
66Acute myeloid leukemia (HP:0004808)2.30017299
67Abnormality of eosinophils (HP:0001879)2.29613094
68Hypoplasia of the thymus (HP:0000778)2.27165647
69Recurrent sinusitis (HP:0011108)2.25277095
70Increased mean platelet volume (HP:0011877)2.24289071
71Keratoconjunctivitis (HP:0001096)2.23762257
72Increased IgM level (HP:0003496)2.22569258
73Amaurosis fugax (HP:0100576)2.22242554
74Recurrent pneumonia (HP:0006532)2.21538606
75Abnormality of T cell number (HP:0011839)2.21081992
76Periodontitis (HP:0000704)2.20803235
77Increased density of long bones (HP:0006392)2.20782944
78Vasculitis (HP:0002633)2.20582064
79Panhypogammaglobulinemia (HP:0003139)2.20465115
80IgA deficiency (HP:0002720)2.18488946
81Recurrent lower respiratory tract infections (HP:0002783)2.17095599
82Abnormality of macrophages (HP:0004311)2.16739058
83Abnormality of the fingertips (HP:0001211)2.16176040
84Entropion (HP:0000621)2.12432953
85Poikiloderma (HP:0001029)2.11885349
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.11773972
87Osteolytic defects of the hand bones (HP:0009699)2.11773972
88Clubbing of toes (HP:0100760)2.11042225
89Chronic mucocutaneous candidiasis (HP:0002728)2.10231374
90Recurrent cutaneous fungal infections (HP:0011370)2.10231374
91Inflammation of the large intestine (HP:0002037)2.09736035
92Gastrointestinal inflammation (HP:0004386)2.09613537
93Papilloma (HP:0012740)2.09085417
94Verrucae (HP:0200043)2.09085417
95Fatigue (HP:0012378)2.08916019
96Acute hepatic failure (HP:0006554)2.08832389
97Abnormality of the preputium (HP:0100587)2.07822941
98IgG deficiency (HP:0004315)2.06908697
99Thyroiditis (HP:0100646)2.05769702
100Albinism (HP:0001022)2.05543255
101Bone marrow hypocellularity (HP:0005528)2.04285678
102Bronchitis (HP:0012387)2.03673750
103Gastrointestinal stroma tumor (HP:0100723)2.03672057
104Hematochezia (HP:0002573)2.03375398
105Leukopenia (HP:0001882)2.01884917
106Granulocytopenia (HP:0001913)2.01872299
107Eosinophilia (HP:0001880)2.01871136
10811 pairs of ribs (HP:0000878)2.01679940
109Epistaxis (HP:0000421)2.01000717
110Basal cell carcinoma (HP:0002671)1.99738944
111Skin ulcer (HP:0200042)1.98610666
112Subacute progressive viral hepatitis (HP:0006572)1.98598703
113Abnormal platelet function (HP:0011869)1.97403233
114Impaired platelet aggregation (HP:0003540)1.97403233
115Urticaria (HP:0001025)1.97391424
116Autoimmune thrombocytopenia (HP:0001973)1.96967657
117Pallor (HP:0000980)1.96109522
118Chest pain (HP:0100749)1.95925313
119Meckel diverticulum (HP:0002245)1.95649339
120Abnormality of the pleura (HP:0002103)1.95196014
121Prominent nose (HP:0000448)1.94444088
122Hypergammaglobulinemia (HP:0010702)1.93508942
123Gingivitis (HP:0000230)1.92586494
124Leukocytosis (HP:0001974)1.91541571
125Absent frontal sinuses (HP:0002688)1.91096077
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.90067349
127Pulmonary embolism (HP:0002204)1.89807501
128Pustule (HP:0200039)1.89031336
129Pulmonary fibrosis (HP:0002206)1.86547300
130Abnormality of the ileum (HP:0001549)1.86491008
131Increased nuchal translucency (HP:0010880)1.85903853
132Chronic sinusitis (HP:0011109)1.85304565
133Orchitis (HP:0100796)1.83972865
134Sepsis (HP:0100806)1.81826429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.63463473
2MAP4K13.31973054
3IRAK42.30838493
4WEE12.30084682
5PRPF4B2.29962263
6NME22.20031762
7KIT2.15620183
8STK102.15226467
9NEK22.10146905
10MARK32.08513381
11BTK1.97324899
12EEF2K1.96223300
13EIF2AK11.94158172
14BMPR21.88506667
15TEC1.83765755
16ACVR1B1.73348926
17SIK31.68816035
18BLK1.66354390
19BRSK21.63028925
20MAP2K31.62210359
21CSF1R1.62168231
22SCYL21.61409747
23NLK1.59907260
24ATR1.58025592
25LRRK21.55608868
26TYK21.52314934
27RPS6KA41.50883516
28MAP3K131.49994791
29STK41.49731697
30CLK11.48547820
31CDK41.42744078
32FRK1.41617530
33MELK1.39226103
34PIM11.37832367
35PKN21.37222813
36MAP3K141.33569174
37SYK1.32299297
38MST1R1.31556550
39EIF2AK31.29785034
40GRK61.29731723
41ZAP701.29312356
42TRPM71.28570412
43SRPK11.26648444
44ERN11.25151669
45TGFBR11.22805230
46JAK31.21953381
47AURKB1.21411763
48TXK1.20883793
49MST41.20711421
50NEK11.20094608
51BUB11.19383474
52MAP3K81.19018032
53TLK11.17175324
54PIM21.17169819
55FLT31.17091140
56CDK61.16641000
57CDK71.16515331
58PASK1.16308295
59VRK11.15349883
60MAP3K101.11348111
61TESK21.10437471
62MAP3K31.07916708
63MKNK11.07636786
64RPS6KB21.06833708
65SMG11.05410592
66ITK1.03949131
67NEK91.02705375
68TTN1.01904078
69JAK21.01114696
70LYN1.00811703
71TAF10.98260368
72TBK10.98211644
73CDK120.97184242
74PLK10.93375664
75MAP2K60.92116705
76HCK0.91314876
77FGFR40.90761455
78TGFBR20.90256508
79TTK0.89971494
80PIK3CG0.89832820
81MUSK0.88473530
82FGR0.87555469
83FES0.87218484
84LCK0.85872806
85STK160.84099603
86BRSK10.82563510
87CHEK20.80922367
88CDK80.79826895
89CSK0.79501443
90IKBKB0.77731634
91PAK40.77707372
92CCNB10.76081433
93IKBKE0.75599872
94ZAK0.74353276
95TSSK60.73878213
96PLK40.71926008
97HIPK20.70633031
98YES10.70511766
99JAK10.69808282
100CHEK10.69531505
101BRD40.68078549
102EIF2AK20.66142572
103DYRK30.65506706
104TAOK30.64925824
105MATK0.64174974
106RIPK40.64007310
107PRKCH0.63991725
108TAOK20.60759129
109PLK30.60107662
110MKNK20.59536501
111ATM0.59447749
112NUAK10.59123130
113PRKCQ0.58981473
114PRKD20.58814249
115IRAK30.56924842
116KDR0.55182241
117CDC42BPA0.55003314
118ERBB30.54877906
119TRIB30.53092474
120RPS6KA60.52543222
121FGFR30.51809745
122RPS6KC10.49883930
123RPS6KL10.49883930
124FER0.49741896
125TESK10.49392540
126ALK0.48058443
127CDK90.47933007
128AKT30.47602296
129IRAK10.47136743
130EPHB10.46694810
131MAPK110.46304066
132CDK20.45449890
133CHUK0.42582701
134MAPK70.41225847
135MAPKAPK20.40099901
136TNK20.39503319
137ABL10.38432543
138MAPK40.36516271

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.06411406
2Mismatch repair_Homo sapiens_hsa034303.86678033
3Base excision repair_Homo sapiens_hsa034102.80678986
4Autoimmune thyroid disease_Homo sapiens_hsa053202.61166499
5Homologous recombination_Homo sapiens_hsa034402.59606487
6Cell cycle_Homo sapiens_hsa041102.35389940
7Ribosome_Homo sapiens_hsa030102.24089637
8Nucleotide excision repair_Homo sapiens_hsa034202.16109354
9Non-homologous end-joining_Homo sapiens_hsa034502.06635990
10Spliceosome_Homo sapiens_hsa030402.03274510
11Primary immunodeficiency_Homo sapiens_hsa053402.00509163
12Fanconi anemia pathway_Homo sapiens_hsa034601.91286924
13One carbon pool by folate_Homo sapiens_hsa006701.85906878
14Leishmaniasis_Homo sapiens_hsa051401.85670067
15Type I diabetes mellitus_Homo sapiens_hsa049401.83724435
16Antigen processing and presentation_Homo sapiens_hsa046121.80526375
17B cell receptor signaling pathway_Homo sapiens_hsa046621.78583618
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70851568
19RNA transport_Homo sapiens_hsa030131.64364123
20p53 signaling pathway_Homo sapiens_hsa041151.53609427
21Systemic lupus erythematosus_Homo sapiens_hsa053221.53432330
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.53116501
23Herpes simplex infection_Homo sapiens_hsa051681.52396158
24Pyrimidine metabolism_Homo sapiens_hsa002401.46882661
25Measles_Homo sapiens_hsa051621.46001089
26Hematopoietic cell lineage_Homo sapiens_hsa046401.43565909
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35956959
28Osteoclast differentiation_Homo sapiens_hsa043801.30701730
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30334428
30Viral carcinogenesis_Homo sapiens_hsa052031.28331455
31Legionellosis_Homo sapiens_hsa051341.26316148
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.22782416
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21193779
34Proteasome_Homo sapiens_hsa030501.19953392
35Shigellosis_Homo sapiens_hsa051311.19182636
36RNA degradation_Homo sapiens_hsa030181.18668111
37Hepatitis B_Homo sapiens_hsa051611.18009217
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13469961
39Apoptosis_Homo sapiens_hsa042101.12599634
40Epstein-Barr virus infection_Homo sapiens_hsa051691.12576705
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11402752
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10076357
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05977231
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05658842
45Small cell lung cancer_Homo sapiens_hsa052221.04032743
46Chronic myeloid leukemia_Homo sapiens_hsa052201.03319903
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.02719992
48Pertussis_Homo sapiens_hsa051331.01673112
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00465136
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00407270
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00089446
52Viral myocarditis_Homo sapiens_hsa054160.98019536
53RNA polymerase_Homo sapiens_hsa030200.96602319
54Influenza A_Homo sapiens_hsa051640.93699635
55Platelet activation_Homo sapiens_hsa046110.93276417
56HTLV-I infection_Homo sapiens_hsa051660.92058249
57Pancreatic cancer_Homo sapiens_hsa052120.91522691
58Toxoplasmosis_Homo sapiens_hsa051450.91428336
59mRNA surveillance pathway_Homo sapiens_hsa030150.90869969
60Tuberculosis_Homo sapiens_hsa051520.90213026
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.88161143
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87796742
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84584042
64Other glycan degradation_Homo sapiens_hsa005110.82524965
65African trypanosomiasis_Homo sapiens_hsa051430.81830580
66MicroRNAs in cancer_Homo sapiens_hsa052060.80709144
67Non-small cell lung cancer_Homo sapiens_hsa052230.80606963
68Malaria_Homo sapiens_hsa051440.77931310
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.77823273
70N-Glycan biosynthesis_Homo sapiens_hsa005100.77117043
71T cell receptor signaling pathway_Homo sapiens_hsa046600.74255222
72Staphylococcus aureus infection_Homo sapiens_hsa051500.71138605
73Acute myeloid leukemia_Homo sapiens_hsa052210.69659694
74Salmonella infection_Homo sapiens_hsa051320.69327961
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69276189
76Rheumatoid arthritis_Homo sapiens_hsa053230.68098742
77Chemokine signaling pathway_Homo sapiens_hsa040620.66883852
78TNF signaling pathway_Homo sapiens_hsa046680.64762652
79Pentose phosphate pathway_Homo sapiens_hsa000300.61885482
80Prolactin signaling pathway_Homo sapiens_hsa049170.60182280
81Asthma_Homo sapiens_hsa053100.59842454
82FoxO signaling pathway_Homo sapiens_hsa040680.59505740
83Purine metabolism_Homo sapiens_hsa002300.57918007
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56657057
85Basal transcription factors_Homo sapiens_hsa030220.56647017
86Renal cell carcinoma_Homo sapiens_hsa052110.53437954
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52976986
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51165311
89Endometrial cancer_Homo sapiens_hsa052130.51019844
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48709883
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.48704634
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48080002
93Colorectal cancer_Homo sapiens_hsa052100.47497545
94Phagosome_Homo sapiens_hsa041450.47368683
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47349490
96Allograft rejection_Homo sapiens_hsa053300.45881493
97Renin-angiotensin system_Homo sapiens_hsa046140.45489161
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45119443
99Dorso-ventral axis formation_Homo sapiens_hsa043200.43039710
100Alcoholism_Homo sapiens_hsa050340.42355508
101Thyroid cancer_Homo sapiens_hsa052160.41852744
102Graft-versus-host disease_Homo sapiens_hsa053320.41359779
103Hepatitis C_Homo sapiens_hsa051600.40511715
104Choline metabolism in cancer_Homo sapiens_hsa052310.39077259
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38980253
106HIF-1 signaling pathway_Homo sapiens_hsa040660.38269197
107Protein export_Homo sapiens_hsa030600.35729802
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.35686778
109Prostate cancer_Homo sapiens_hsa052150.35514252
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35461665
111Lysosome_Homo sapiens_hsa041420.35347486
112Inositol phosphate metabolism_Homo sapiens_hsa005620.34883468
113Lysine degradation_Homo sapiens_hsa003100.34788098
114Insulin resistance_Homo sapiens_hsa049310.33742246
115Proteoglycans in cancer_Homo sapiens_hsa052050.32905130
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31815757
117VEGF signaling pathway_Homo sapiens_hsa043700.31293473
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31287892
119Pathways in cancer_Homo sapiens_hsa052000.30146751
120Notch signaling pathway_Homo sapiens_hsa043300.29010887
121Bladder cancer_Homo sapiens_hsa052190.28033140
122mTOR signaling pathway_Homo sapiens_hsa041500.27639637
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.26957699
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.26788033

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