FAM110D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.03180657
2response to pheromone (GO:0019236)4.98176319
3L-fucose catabolic process (GO:0042355)4.81522655
4fucose catabolic process (GO:0019317)4.81522655
5L-fucose metabolic process (GO:0042354)4.81522655
6sulfation (GO:0051923)4.12751289
7indolalkylamine metabolic process (GO:0006586)3.93044824
8kynurenine metabolic process (GO:0070189)3.85895067
9tryptophan catabolic process (GO:0006569)3.79097309
10indole-containing compound catabolic process (GO:0042436)3.79097309
11indolalkylamine catabolic process (GO:0046218)3.79097309
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.77114722
13gamma-aminobutyric acid transport (GO:0015812)3.77013125
14serotonin metabolic process (GO:0042428)3.74009874
15nephron epithelium morphogenesis (GO:0072088)3.65828601
16nephron tubule morphogenesis (GO:0072078)3.65828601
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65334300
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.65334300
19NADH dehydrogenase complex assembly (GO:0010257)3.65334300
20tryptophan metabolic process (GO:0006568)3.63867413
21indole-containing compound metabolic process (GO:0042430)3.44774151
22regulation of gene silencing by RNA (GO:0060966)3.44326109
23regulation of posttranscriptional gene silencing (GO:0060147)3.44326109
24regulation of gene silencing by miRNA (GO:0060964)3.44326109
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.42550823
26regulation of hippo signaling (GO:0035330)3.42041302
27protein complex biogenesis (GO:0070271)3.40334826
28primary amino compound metabolic process (GO:1901160)3.34813294
29ATP synthesis coupled proton transport (GO:0015986)3.27777410
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27777410
31spinal cord motor neuron differentiation (GO:0021522)3.19850824
32mitochondrial respiratory chain complex assembly (GO:0033108)3.13973922
33water-soluble vitamin biosynthetic process (GO:0042364)3.13913056
34nonmotile primary cilium assembly (GO:0035058)3.10709425
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05411372
36otic vesicle formation (GO:0030916)3.04409178
37neuronal action potential (GO:0019228)3.02672956
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95736414
39negative regulation of systemic arterial blood pressure (GO:0003085)2.94354465
40presynaptic membrane assembly (GO:0097105)2.84471298
41cell proliferation in forebrain (GO:0021846)2.82099516
42cellular ketone body metabolic process (GO:0046950)2.80611067
43cAMP catabolic process (GO:0006198)2.80103495
44kidney morphogenesis (GO:0060993)2.79441011
45purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.74782353
463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.74782353
47neuron fate determination (GO:0048664)2.74601838
48negative regulation of translation, ncRNA-mediated (GO:0040033)2.73150192
49regulation of translation, ncRNA-mediated (GO:0045974)2.73150192
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73150192
51behavioral response to ethanol (GO:0048149)2.72992129
52regulation of histone phosphorylation (GO:0033127)2.70922076
53renal tubule morphogenesis (GO:0061333)2.70486409
54detection of light stimulus involved in visual perception (GO:0050908)2.68421784
55detection of light stimulus involved in sensory perception (GO:0050962)2.68421784
56negative regulation of telomere maintenance (GO:0032205)2.67114713
57somite development (GO:0061053)2.66700273
58neuronal stem cell maintenance (GO:0097150)2.66122147
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64601086
60negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64293474
61negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.63450344
62mitochondrion morphogenesis (GO:0070584)2.62324952
63phosphatidylinositol acyl-chain remodeling (GO:0036149)2.60994950
64NAD biosynthetic process (GO:0009435)2.60591575
65DNA deamination (GO:0045006)2.58523503
66electron transport chain (GO:0022900)2.57818825
67epithelial cilium movement (GO:0003351)2.54568845
68intracellular protein transmembrane import (GO:0044743)2.54506425
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53293278
70negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53189165
71limb bud formation (GO:0060174)2.52819201
72protein import into peroxisome matrix (GO:0016558)2.52103827
73positive regulation of cAMP-mediated signaling (GO:0043950)2.51684787
74negative regulation of astrocyte differentiation (GO:0048712)2.51476347
75ketone body metabolic process (GO:1902224)2.50469230
76startle response (GO:0001964)2.49707130
77hindbrain development (GO:0030902)2.47834713
78ubiquinone biosynthetic process (GO:0006744)2.47392021
79positive regulation of fatty acid oxidation (GO:0046321)2.47280269
80platelet dense granule organization (GO:0060155)2.46927986
81transmission of nerve impulse (GO:0019226)2.46244242
82respiratory electron transport chain (GO:0022904)2.45426681
83histone-serine phosphorylation (GO:0035404)2.44867886
84cornea development in camera-type eye (GO:0061303)2.43744476
85fucosylation (GO:0036065)2.43566570
86respiratory chain complex IV assembly (GO:0008535)2.43359051
87cyclic nucleotide catabolic process (GO:0009214)2.43235062
88thalamus development (GO:0021794)2.42811194
89synapsis (GO:0007129)2.42477073
90regulation of mesenchymal cell apoptotic process (GO:2001053)2.41634175
91regulation of nuclear cell cycle DNA replication (GO:0033262)2.41231165
92photoreceptor cell development (GO:0042461)2.41170420
93regulation of mesoderm development (GO:2000380)2.40578598
94neuromuscular synaptic transmission (GO:0007274)2.40457713
95cilium organization (GO:0044782)2.39789512
96pyrimidine nucleobase catabolic process (GO:0006208)2.39632560
97peristalsis (GO:0030432)2.39622002
98signal peptide processing (GO:0006465)2.38826669
99male meiosis I (GO:0007141)2.38713386
100neural tube formation (GO:0001841)2.38708446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.03221139
2EZH2_22144423_ChIP-Seq_EOC_Human4.01547393
3VDR_22108803_ChIP-Seq_LS180_Human3.16414481
4GBX2_23144817_ChIP-Seq_PC3_Human2.90832614
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70923753
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63547893
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51200038
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42438279
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42295060
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39891303
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23284779
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19988402
13EWS_26573619_Chip-Seq_HEK293_Human2.13219026
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.08442272
15FUS_26573619_Chip-Seq_HEK293_Human2.05024070
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02401076
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92610431
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89862807
19P300_19829295_ChIP-Seq_ESCs_Human1.79491170
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78354881
21ER_23166858_ChIP-Seq_MCF-7_Human1.78218457
22TAF15_26573619_Chip-Seq_HEK293_Human1.75240198
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70961703
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68102149
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.66738356
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.59712018
27MYC_18940864_ChIP-ChIP_HL60_Human1.58889021
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57440926
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.56960966
30REST_21632747_ChIP-Seq_MESCs_Mouse1.54030973
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51486959
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.50831869
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50087626
34BCAT_22108803_ChIP-Seq_LS180_Human1.48137236
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.47945232
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47897265
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46154045
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.46027137
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45386361
40AR_25329375_ChIP-Seq_VCAP_Human1.44121299
41AR_21572438_ChIP-Seq_LNCaP_Human1.42883710
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42729110
43IGF1R_20145208_ChIP-Seq_DFB_Human1.41666655
44RNF2_27304074_Chip-Seq_NSC_Mouse1.40085509
45STAT3_23295773_ChIP-Seq_U87_Human1.36419345
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35825169
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34503853
48IRF1_19129219_ChIP-ChIP_H3396_Human1.34154634
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33844707
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33743239
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32221623
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32221623
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32034985
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.31856055
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31851060
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.31851060
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30073460
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29355661
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28551115
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28068107
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26545560
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26385995
63TP53_22573176_ChIP-Seq_HFKS_Human1.26363363
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22567750
65SMAD4_21799915_ChIP-Seq_A2780_Human1.22157852
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21801776
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.21612525
68TP53_16413492_ChIP-PET_HCT116_Human1.19546557
69TCF4_23295773_ChIP-Seq_U87_Human1.18554360
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.17930949
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.17685823
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.16938919
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16262908
74CBP_20019798_ChIP-Seq_JUKART_Human1.16262908
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13005582
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.12018544
77SOX2_19829295_ChIP-Seq_ESCs_Human1.11798057
78NANOG_19829295_ChIP-Seq_ESCs_Human1.11798057
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11112357
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.08988386
81RUNX2_22187159_ChIP-Seq_PCA_Human1.07562794
82TCF4_22108803_ChIP-Seq_LS180_Human1.06881786
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05536230
84TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05014531
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04954352
86ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03852135
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.02564625
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.00917248
89HOXB7_26014856_ChIP-Seq_BT474_Human1.00679944
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00637720
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99903296
92DROSHA_22980978_ChIP-Seq_HELA_Human0.99849394
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99307494
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99281880
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99197311
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98855448
97NCOR_22424771_ChIP-Seq_293T_Human0.98543821
98EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98117904
99RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98117904
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97928398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.61527591
2MP0002653_abnormal_ependyma_morphology2.73029317
3MP0000569_abnormal_digit_pigmentation2.51143128
4MP0005551_abnormal_eye_electrophysiolog2.32004477
5MP0009379_abnormal_foot_pigmentation2.27488780
6MP0001485_abnormal_pinna_reflex2.25651084
7MP0001968_abnormal_touch/_nociception2.22364284
8MP0004885_abnormal_endolymph2.22019557
9MP0003195_calcinosis2.11292182
10MP0002938_white_spotting2.11129540
11MP0004142_abnormal_muscle_tone2.09094985
12MP0002102_abnormal_ear_morphology2.08839094
13MP0009745_abnormal_behavioral_response2.07941796
14MP0008872_abnormal_physiological_respon2.05386133
15MP0006292_abnormal_olfactory_placode2.03885821
16MP0009046_muscle_twitch1.98779752
17MP0004742_abnormal_vestibular_system1.97437623
18MP0000631_abnormal_neuroendocrine_gland1.95183501
19MP0004133_heterotaxia1.90032671
20MP0006072_abnormal_retinal_apoptosis1.88996459
21MP0002272_abnormal_nervous_system1.85102964
22MP0002736_abnormal_nociception_after1.81185078
23MP0002735_abnormal_chemical_nociception1.70235021
24MP0001986_abnormal_taste_sensitivity1.62782237
25MP0004145_abnormal_muscle_electrophysio1.61062242
26MP0008877_abnormal_DNA_methylation1.60683846
27MP0002638_abnormal_pupillary_reflex1.60163320
28MP0002277_abnormal_respiratory_mucosa1.59047808
29MP0005171_absent_coat_pigmentation1.57541655
30MP0002064_seizures1.56980753
31MP0002160_abnormal_reproductive_system1.55446543
32MP0001501_abnormal_sleep_pattern1.54455954
33MP0005253_abnormal_eye_physiology1.53893002
34MP0003646_muscle_fatigue1.51640345
35MP0003283_abnormal_digestive_organ1.51637640
36MP0005084_abnormal_gallbladder_morpholo1.50848407
37MP0008875_abnormal_xenobiotic_pharmacok1.50250037
38MP0003011_delayed_dark_adaptation1.45207161
39MP0002572_abnormal_emotion/affect_behav1.40707972
40MP0004043_abnormal_pH_regulation1.36828661
41MP0001529_abnormal_vocalization1.36648293
42MP0005646_abnormal_pituitary_gland1.35676279
43MP0002067_abnormal_sensory_capabilities1.33950824
44MP0000049_abnormal_middle_ear1.31390262
45MP0005389_reproductive_system_phenotype1.29363553
46MP0005645_abnormal_hypothalamus_physiol1.29018033
47MP0001486_abnormal_startle_reflex1.28403784
48MP0002557_abnormal_social/conspecific_i1.27281476
49MP0002733_abnormal_thermal_nociception1.27079670
50MP0002837_dystrophic_cardiac_calcinosis1.27017045
51MP0002876_abnormal_thyroid_physiology1.25603341
52MP0003880_abnormal_central_pattern1.23991522
53MP0001970_abnormal_pain_threshold1.22094034
54MP0005423_abnormal_somatic_nervous1.21351339
55MP0002734_abnormal_mechanical_nocicepti1.21121679
56MP0005174_abnormal_tail_pigmentation1.20997222
57MP0005195_abnormal_posterior_eye1.20434369
58MP0000026_abnormal_inner_ear1.20259585
59MP0003119_abnormal_digestive_system1.19259688
60MP0000427_abnormal_hair_cycle1.18034962
61MP0003937_abnormal_limbs/digits/tail_de1.14668575
62MP0003635_abnormal_synaptic_transmissio1.13893897
63MP0000372_irregular_coat_pigmentation1.12595496
64MP0000778_abnormal_nervous_system1.09176741
65MP0002063_abnormal_learning/memory/cond1.08962891
66MP0002928_abnormal_bile_duct1.08791050
67MP0003890_abnormal_embryonic-extraembry1.07607740
68MP0006276_abnormal_autonomic_nervous1.06033301
69MP0000383_abnormal_hair_follicle1.04430708
70MP0000566_synostosis1.01959355
71MP0002751_abnormal_autonomic_nervous1.01683073
72MP0009384_cardiac_valve_regurgitation1.01271602
73MP0005386_behavior/neurological_phenoty1.01133676
74MP0004924_abnormal_behavior1.01133676
75MP0002752_abnormal_somatic_nervous0.99816891
76MP0001293_anophthalmia0.99186131
77MP0001905_abnormal_dopamine_level0.98466060
78MP0005085_abnormal_gallbladder_physiolo0.97991913
79MP0002282_abnormal_trachea_morphology0.97500791
80MP0005503_abnormal_tendon_morphology0.95958164
81MP0004130_abnormal_muscle_cell0.94728117
82MP0001919_abnormal_reproductive_system0.92498297
83MP0001984_abnormal_olfaction0.91903876
84MP0003718_maternal_effect0.91881518
85MP0001963_abnormal_hearing_physiology0.86561908
86MP0005083_abnormal_biliary_tract0.86100467
87MP0002095_abnormal_skin_pigmentation0.85851505
88MP0003315_abnormal_perineum_morphology0.85308040
89MP0002138_abnormal_hepatobiliary_system0.81734247
90MP0004147_increased_porphyrin_level0.80896353
91MP0009250_abnormal_appendicular_skeleto0.79867482
92MP0004215_abnormal_myocardial_fiber0.79450353
93MP0003638_abnormal_response/metabolism_0.79047190
94MP0003137_abnormal_impulse_conducting0.78492559
95MP0003698_abnormal_male_reproductive0.77709281
96MP0003878_abnormal_ear_physiology0.77532775
97MP0005377_hearing/vestibular/ear_phenot0.77532775
98MP0005187_abnormal_penis_morphology0.76198195
99MP0000230_abnormal_systemic_arterial0.76042073
100MP0002184_abnormal_innervation0.75261222

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.30941380
2Congenital, generalized hypertrichosis (HP:0004540)4.16215083
3True hermaphroditism (HP:0010459)4.13948729
4Abnormality of midbrain morphology (HP:0002418)3.99814347
5Molar tooth sign on MRI (HP:0002419)3.99814347
6Pancreatic fibrosis (HP:0100732)3.90194916
7Type II lissencephaly (HP:0007260)3.78701493
8Nephronophthisis (HP:0000090)3.58794901
9Large for gestational age (HP:0001520)3.23662597
10Pendular nystagmus (HP:0012043)3.14739304
11Congenital stationary night blindness (HP:0007642)3.11820417
12Abnormality of the renal medulla (HP:0100957)3.10904512
13Furrowed tongue (HP:0000221)3.10814494
14Abnormality of the renal cortex (HP:0011035)3.01741164
15Abnormality of the pons (HP:0007361)2.96507863
16Abnormality of alanine metabolism (HP:0010916)2.94512594
17Hyperalaninemia (HP:0003348)2.94512594
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.94512594
19Hyperventilation (HP:0002883)2.93644358
20Hypoplasia of the pons (HP:0012110)2.88428037
21Tubular atrophy (HP:0000092)2.87950304
22Abnormal number of erythroid precursors (HP:0012131)2.87819619
23Concave nail (HP:0001598)2.80156043
24Absent/shortened dynein arms (HP:0200106)2.72837070
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.72837070
26Cystic liver disease (HP:0006706)2.60327884
27Cerebellar dysplasia (HP:0007033)2.60150214
28Birth length less than 3rd percentile (HP:0003561)2.56663221
29Severe muscular hypotonia (HP:0006829)2.53152872
30Abolished electroretinogram (ERG) (HP:0000550)2.52673070
31Sclerocornea (HP:0000647)2.51139174
32Attenuation of retinal blood vessels (HP:0007843)2.50231424
33Genetic anticipation (HP:0003743)2.48978450
34Medial flaring of the eyebrow (HP:0010747)2.46032858
35Abnormality of cells of the erythroid lineage (HP:0012130)2.44505971
36Increased corneal curvature (HP:0100692)2.42358711
37Keratoconus (HP:0000563)2.42358711
38Progressive cerebellar ataxia (HP:0002073)2.40325449
39Inability to walk (HP:0002540)2.33868649
40Patellar aplasia (HP:0006443)2.33210957
41Aplasia/Hypoplasia of the patella (HP:0006498)2.31619491
42Abnormal respiratory epithelium morphology (HP:0012253)2.27441693
43Abnormal respiratory motile cilium morphology (HP:0005938)2.27441693
44Duplicated collecting system (HP:0000081)2.22345330
45Abnormality of the renal collecting system (HP:0004742)2.21265806
46Gaze-evoked nystagmus (HP:0000640)2.20535252
47Septo-optic dysplasia (HP:0100842)2.20327121
48Hypothermia (HP:0002045)2.17642197
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.17223162
50Abnormal ciliary motility (HP:0012262)2.16922274
51Acute necrotizing encephalopathy (HP:0006965)2.15973208
523-Methylglutaconic aciduria (HP:0003535)2.14875612
53Meningioma (HP:0002858)2.13516875
54Short hallux (HP:0010109)2.13508660
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12260097
56Chorioretinal atrophy (HP:0000533)2.10421301
57Lissencephaly (HP:0001339)2.10097042
58Limb dystonia (HP:0002451)2.08756910
59Conjunctival hamartoma (HP:0100780)2.08226962
60Male pseudohermaphroditism (HP:0000037)2.07022275
61Anencephaly (HP:0002323)2.07000080
62Optic nerve hypoplasia (HP:0000609)2.06704233
63Mitochondrial inheritance (HP:0001427)2.02687599
64Chronic hepatic failure (HP:0100626)2.02020839
65Hemiparesis (HP:0001269)2.00134895
66Hypoplastic ischia (HP:0003175)1.97977109
67Aplasia/Hypoplasia of the hallux (HP:0008362)1.97791101
68Progressive inability to walk (HP:0002505)1.95493815
69Congenital hepatic fibrosis (HP:0002612)1.94905597
70Abnormal drinking behavior (HP:0030082)1.94379222
71Polydipsia (HP:0001959)1.94379222
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.90245642
73Tachypnea (HP:0002789)1.90020511
74Optic disc pallor (HP:0000543)1.89816585
75Absent thumb (HP:0009777)1.89038885
76Decreased central vision (HP:0007663)1.88116155
77Progressive macrocephaly (HP:0004481)1.87216576
78Lipid accumulation in hepatocytes (HP:0006561)1.86993614
79Pheochromocytoma (HP:0002666)1.85610342
80Bilateral microphthalmos (HP:0007633)1.83696636
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.83631417
82Acute encephalopathy (HP:0006846)1.82568825
83Gait imbalance (HP:0002141)1.82495177
84Prominent supraorbital ridges (HP:0000336)1.81587152
85Reticulocytopenia (HP:0001896)1.81135433
86Focal motor seizures (HP:0011153)1.80827613
87Abnormality of the carotid arteries (HP:0005344)1.80369425
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.79664984
89Mesangial abnormality (HP:0001966)1.78733764
90Protruding tongue (HP:0010808)1.78389125
91Broad-based gait (HP:0002136)1.78351962
92Ulnar claw (HP:0001178)1.77988501
93Increased CSF lactate (HP:0002490)1.77906340
94Renal cortical cysts (HP:0000803)1.77797116
95Bone cyst (HP:0012062)1.77143813
96Abnormal rod and cone electroretinograms (HP:0008323)1.75058499
97Increased hepatocellular lipid droplets (HP:0006565)1.74768971
98Agitation (HP:0000713)1.74594141
99Tinnitus (HP:0000360)1.72393334
100Abnormal mitochondria in muscle tissue (HP:0008316)1.71719726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.29474795
2FRK4.02333785
3ADRBK23.56014848
4BMPR1B3.35885796
5ZAK3.21004244
6GRK12.72046863
7ACVR1B2.71180358
8WEE12.62007928
9MAPK152.33506905
10TLK12.23039689
11WNK42.21704499
12WNK32.19904119
13INSRR2.13049635
14CASK2.12052687
15TSSK61.99174277
16VRK11.82945228
17MAPK131.82024014
18TGFBR11.75684928
19TAOK31.73886927
20PINK11.59916820
21MAP4K21.59696288
22NUAK11.56814041
23MAPKAPK51.55892753
24TAF11.49937708
25MKNK21.47675468
26DAPK21.44367063
27MAP3K41.42022220
28IRAK11.41161846
29ADRBK11.37050571
30VRK21.33381191
31TNIK1.32885186
32STK391.22891923
33OXSR11.20759085
34MARK11.19826239
35PRKCG1.19180294
36BRSK21.14009791
37NTRK31.13213954
38DYRK21.10643566
39TIE11.10409339
40CAMKK21.06191330
41PTK2B1.03292839
42PKN10.93578931
43RPS6KA50.92263614
44PLK40.89782326
45NTRK20.89637930
46NME10.88936403
47PAK30.88386618
48CAMK1D0.87019105
49PLK30.85428108
50NEK20.80302556
51MKNK10.79106464
52MAP2K70.77473086
53MAPKAPK30.76890726
54PRKCE0.71064007
55CDC70.70482888
56MUSK0.69100810
57BUB10.63820935
58MAP2K20.59851367
59CAMK1G0.58527852
60CAMK2A0.58397202
61MAP2K10.56600113
62CHEK20.53175101
63IRAK40.50058101
64PHKG10.49143722
65PHKG20.49143722
66STK110.48646653
67KIT0.48239390
68RPS6KA60.47060009
69CDK30.46987685
70DYRK30.46901558
71EPHB20.46645708
72PRKACA0.43921697
73TRPM70.42721009
74PIK3CA0.41284303
75STK38L0.40752675
76CAMK10.39980752
77PLK10.39808253
78PRKCQ0.39044052
79NEK90.38146408
80EPHA40.36988474
81PLK20.36267893
82ERBB20.35479053
83CSNK1G20.34963669
84MAP2K40.33809336
85PRKG10.33766488
86MAP2K60.33688016
87IKBKB0.32731672
88GRK70.31790228
89PRKCI0.30697659
90CSNK1A10.30605412
91OBSCN0.30362262
92STK30.28704804
93CHUK0.28244536
94PASK0.28184502
95PRKCZ0.26418945
96PRKCA0.25896453
97CSNK1G10.24650808
98CAMK2B0.23805468
99MET0.21932259
100CSNK2A10.21911234

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.99034347
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.85559095
3Nitrogen metabolism_Homo sapiens_hsa009102.83163782
4Linoleic acid metabolism_Homo sapiens_hsa005912.78687299
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.69201939
6Phototransduction_Homo sapiens_hsa047442.55300298
7Parkinsons disease_Homo sapiens_hsa050122.44642992
8Nicotine addiction_Homo sapiens_hsa050332.41985219
9Ribosome_Homo sapiens_hsa030102.38680569
10Selenocompound metabolism_Homo sapiens_hsa004502.34695720
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.27696479
12Homologous recombination_Homo sapiens_hsa034402.09328355
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04277266
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02637779
15Butanoate metabolism_Homo sapiens_hsa006501.99240852
16Tryptophan metabolism_Homo sapiens_hsa003801.93528258
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89500396
18Ether lipid metabolism_Homo sapiens_hsa005651.80151152
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76059972
20Huntingtons disease_Homo sapiens_hsa050161.67787393
21Cardiac muscle contraction_Homo sapiens_hsa042601.65197947
22Alzheimers disease_Homo sapiens_hsa050101.64513949
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64301131
24Protein export_Homo sapiens_hsa030601.57118603
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49734517
26RNA polymerase_Homo sapiens_hsa030201.42737568
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40289848
28Fanconi anemia pathway_Homo sapiens_hsa034601.39310787
29Taste transduction_Homo sapiens_hsa047421.38115989
30Basal transcription factors_Homo sapiens_hsa030221.37914972
31Morphine addiction_Homo sapiens_hsa050321.35236487
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34032537
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24570569
34Olfactory transduction_Homo sapiens_hsa047401.17871044
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.16250829
36Chemical carcinogenesis_Homo sapiens_hsa052041.10704838
37Ovarian steroidogenesis_Homo sapiens_hsa049131.10185803
38Basal cell carcinoma_Homo sapiens_hsa052171.09489682
39Glutamatergic synapse_Homo sapiens_hsa047241.08990921
40Arachidonic acid metabolism_Homo sapiens_hsa005901.03451129
41Cocaine addiction_Homo sapiens_hsa050301.02793089
42Caffeine metabolism_Homo sapiens_hsa002321.01743294
43Serotonergic synapse_Homo sapiens_hsa047260.97274830
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97213872
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.96079082
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.94475494
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93488497
48Circadian entrainment_Homo sapiens_hsa047130.91414137
49GABAergic synapse_Homo sapiens_hsa047270.90017527
50Insulin secretion_Homo sapiens_hsa049110.89801422
51RNA degradation_Homo sapiens_hsa030180.86447746
52One carbon pool by folate_Homo sapiens_hsa006700.86214153
53Histidine metabolism_Homo sapiens_hsa003400.83804270
54ABC transporters_Homo sapiens_hsa020100.83354014
55Peroxisome_Homo sapiens_hsa041460.82467528
56Glycerolipid metabolism_Homo sapiens_hsa005610.82226216
57Sulfur relay system_Homo sapiens_hsa041220.82168068
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79740419
59Calcium signaling pathway_Homo sapiens_hsa040200.79603124
60Fat digestion and absorption_Homo sapiens_hsa049750.78508957
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74665137
62Sulfur metabolism_Homo sapiens_hsa009200.74637381
63Systemic lupus erythematosus_Homo sapiens_hsa053220.73274565
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72162273
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69581857
66Retinol metabolism_Homo sapiens_hsa008300.69497775
67Hedgehog signaling pathway_Homo sapiens_hsa043400.68425592
68Propanoate metabolism_Homo sapiens_hsa006400.67611290
69Asthma_Homo sapiens_hsa053100.64229726
70Mineral absorption_Homo sapiens_hsa049780.63007735
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62494013
72Vitamin digestion and absorption_Homo sapiens_hsa049770.60867576
73beta-Alanine metabolism_Homo sapiens_hsa004100.59779781
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58607153
75Purine metabolism_Homo sapiens_hsa002300.58258211
76Alcoholism_Homo sapiens_hsa050340.55175822
77Amphetamine addiction_Homo sapiens_hsa050310.52665734
78Long-term depression_Homo sapiens_hsa047300.51825765
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.51614498
80Metabolic pathways_Homo sapiens_hsa011000.49613461
81Salivary secretion_Homo sapiens_hsa049700.48100384
82Dopaminergic synapse_Homo sapiens_hsa047280.46623137
83cAMP signaling pathway_Homo sapiens_hsa040240.45788876
84Nucleotide excision repair_Homo sapiens_hsa034200.44658257
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.42390009
86Cholinergic synapse_Homo sapiens_hsa047250.40650645
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39144341
88Dorso-ventral axis formation_Homo sapiens_hsa043200.37382486
89Fatty acid biosynthesis_Homo sapiens_hsa000610.35821914
90Axon guidance_Homo sapiens_hsa043600.35414455
91Regulation of autophagy_Homo sapiens_hsa041400.34988644
92Hippo signaling pathway_Homo sapiens_hsa043900.34303498
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34132139
94Collecting duct acid secretion_Homo sapiens_hsa049660.33755455
95Pyrimidine metabolism_Homo sapiens_hsa002400.33303313
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33243545
97Steroid biosynthesis_Homo sapiens_hsa001000.31836979
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31574771
99Bile secretion_Homo sapiens_hsa049760.30864773
100Gastric acid secretion_Homo sapiens_hsa049710.25033205

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