FAM104B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.07378890
2protein neddylation (GO:0045116)5.36620130
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.17756785
4ATP synthesis coupled proton transport (GO:0015986)5.17756785
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.16755969
6protein complex biogenesis (GO:0070271)4.89216291
7proteasome assembly (GO:0043248)4.84239425
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.67581599
9respiratory electron transport chain (GO:0022904)4.66416303
10electron transport chain (GO:0022900)4.62555027
11mitochondrial respiratory chain complex assembly (GO:0033108)4.60555654
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.56006923
13NADH dehydrogenase complex assembly (GO:0010257)4.56006923
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.56006923
15chaperone-mediated protein transport (GO:0072321)4.49251313
16respiratory chain complex IV assembly (GO:0008535)4.35997687
17cytochrome complex assembly (GO:0017004)3.94893090
18rRNA modification (GO:0000154)3.67336945
19epithelial cilium movement (GO:0003351)3.64274609
20cullin deneddylation (GO:0010388)3.60262095
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58881603
22water-soluble vitamin biosynthetic process (GO:0042364)3.49362965
23cilium movement (GO:0003341)3.47419169
24regulation of cilium movement (GO:0003352)3.46236594
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45762724
26platelet dense granule organization (GO:0060155)3.41396287
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38305540
28axonemal dynein complex assembly (GO:0070286)3.37795016
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36860842
30hydrogen ion transmembrane transport (GO:1902600)3.28482343
31protein deneddylation (GO:0000338)3.23353616
32regulation of mitochondrial translation (GO:0070129)3.22380689
33intraciliary transport (GO:0042073)3.22220721
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.22114013
35termination of RNA polymerase III transcription (GO:0006386)3.22114013
36rRNA methylation (GO:0031167)3.16087756
37ATP biosynthetic process (GO:0006754)3.11071223
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10189844
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10082880
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09594713
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09594713
42proton transport (GO:0015992)3.05660003
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03198614
44CENP-A containing nucleosome assembly (GO:0034080)3.01801810
45chromatin remodeling at centromere (GO:0031055)2.99749486
46hydrogen transport (GO:0006818)2.99683124
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99305286
48negative regulation of ligase activity (GO:0051352)2.99305286
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.98573987
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98261918
51regulation of mitotic spindle checkpoint (GO:1903504)2.98261918
52DNA double-strand break processing (GO:0000729)2.97538616
53regulation of cellular amino acid metabolic process (GO:0006521)2.97417635
54protein targeting to mitochondrion (GO:0006626)2.93381189
55protein K11-linked ubiquitination (GO:0070979)2.92987499
56inner mitochondrial membrane organization (GO:0007007)2.92066797
57protein localization to mitochondrion (GO:0070585)2.87403355
58peptidyl-histidine modification (GO:0018202)2.84571363
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84503176
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81644686
61establishment of protein localization to mitochondrion (GO:0072655)2.81549065
62mannosylation (GO:0097502)2.78238340
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76591196
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76591196
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76591196
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.75372478
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73999464
68axoneme assembly (GO:0035082)2.72885966
69glutathione derivative biosynthetic process (GO:1901687)2.72745679
70glutathione derivative metabolic process (GO:1901685)2.72745679
71intracellular protein transmembrane import (GO:0044743)2.72318854
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71797015
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71797015
74mismatch repair (GO:0006298)2.71036697
75cilium or flagellum-dependent cell motility (GO:0001539)2.68359303
76histone mRNA metabolic process (GO:0008334)2.66648570
77signal peptide processing (GO:0006465)2.65095243
78positive regulation of ligase activity (GO:0051351)2.64951106
79protein localization to cilium (GO:0061512)2.62786988
80ribosomal large subunit biogenesis (GO:0042273)2.61976297
81signal transduction involved in cell cycle checkpoint (GO:0072395)2.61750813
82signal transduction involved in DNA integrity checkpoint (GO:0072401)2.61308061
83signal transduction involved in DNA damage checkpoint (GO:0072422)2.61308061
84response to pheromone (GO:0019236)2.60649135
85pseudouridine synthesis (GO:0001522)2.59533693
86centriole replication (GO:0007099)2.59499280
87aldehyde catabolic process (GO:0046185)2.59482634
88oxidative phosphorylation (GO:0006119)2.59133806
89ribonucleoside triphosphate biosynthetic process (GO:0009201)2.59020375
90GTP biosynthetic process (GO:0006183)2.58999405
91nucleoside triphosphate biosynthetic process (GO:0009142)2.56953428
92spliceosomal snRNP assembly (GO:0000387)2.56658705
93resolution of meiotic recombination intermediates (GO:0000712)2.53066279
94mitochondrial transport (GO:0006839)2.52887937
95anterograde synaptic vesicle transport (GO:0048490)2.51651274
96ribosomal small subunit assembly (GO:0000028)2.51645412
97negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.50102625
98kinetochore assembly (GO:0051382)2.48633255
99cilium organization (GO:0044782)2.48042857
100preassembly of GPI anchor in ER membrane (GO:0016254)2.47622393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.46516330
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.00863529
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.80756169
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.64452006
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05715797
6ELK1_19687146_ChIP-ChIP_HELA_Human2.62035810
7ZNF274_21170338_ChIP-Seq_K562_Hela2.49572223
8VDR_22108803_ChIP-Seq_LS180_Human2.47553552
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39456810
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37579734
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37486019
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.37375862
13FUS_26573619_Chip-Seq_HEK293_Human2.24390677
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23016158
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20124064
16EWS_26573619_Chip-Seq_HEK293_Human2.19768037
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19688913
18VDR_23849224_ChIP-Seq_CD4+_Human2.17309153
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16975372
20IGF1R_20145208_ChIP-Seq_DFB_Human2.07950763
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.88754407
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.87751939
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84229154
24TAF15_26573619_Chip-Seq_HEK293_Human1.84059008
25FOXP3_21729870_ChIP-Seq_TREG_Human1.81664226
26GBX2_23144817_ChIP-Seq_PC3_Human1.79653890
27P300_19829295_ChIP-Seq_ESCs_Human1.79140170
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74192305
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74071980
30MYC_18940864_ChIP-ChIP_HL60_Human1.71278921
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70367006
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63592426
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62988215
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61468497
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61241808
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52273549
37* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50228907
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49574156
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.47665222
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43812857
41TP53_22573176_ChIP-Seq_HFKS_Human1.41510600
42DCP1A_22483619_ChIP-Seq_HELA_Human1.41014591
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40764625
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39090048
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.33437889
46NANOG_19829295_ChIP-Seq_ESCs_Human1.32624721
47SOX2_19829295_ChIP-Seq_ESCs_Human1.32624721
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25472169
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.23417208
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22775535
51* ER_23166858_ChIP-Seq_MCF-7_Human1.21731781
52* FOXA1_25329375_ChIP-Seq_VCAP_Human1.20764812
53* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20764812
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19401381
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18774123
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16951956
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16259071
58HTT_18923047_ChIP-ChIP_STHdh_Human1.15877001
59AR_20517297_ChIP-Seq_VCAP_Human1.15188674
60IRF1_19129219_ChIP-ChIP_H3396_Human1.13798927
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13737972
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13422882
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12758819
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12536121
65BCAT_22108803_ChIP-Seq_LS180_Human1.12302729
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.11382762
67* GABP_19822575_ChIP-Seq_HepG2_Human1.11364658
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10776035
69TTF2_22483619_ChIP-Seq_HELA_Human1.10491116
70TCF4_22108803_ChIP-Seq_LS180_Human1.10343478
71AR_25329375_ChIP-Seq_VCAP_Human1.10076955
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09063858
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08742489
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08484888
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08134734
76CBP_20019798_ChIP-Seq_JUKART_Human1.08134734
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07172844
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.06114653
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05530660
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04163534
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04011677
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03492860
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01694665
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00258712
85SMAD4_21799915_ChIP-Seq_A2780_Human1.00186949
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99585812
87* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99252446
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98806412
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97913805
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96881821
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96861239
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.96120472
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.95227469
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94079924
95NCOR_22424771_ChIP-Seq_293T_Human0.93617022
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91603932
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90907840
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.90590602
99RNF2_27304074_Chip-Seq_NSC_Mouse0.90293924
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.89357743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.06041569
2MP0002102_abnormal_ear_morphology2.74968209
3MP0008058_abnormal_DNA_repair2.62703758
4MP0003136_yellow_coat_color2.57436027
5MP0003806_abnormal_nucleotide_metabolis2.49772640
6MP0003195_calcinosis2.47006627
7MP0008877_abnormal_DNA_methylation2.36200942
8MP0000372_irregular_coat_pigmentation2.32576349
9MP0006292_abnormal_olfactory_placode2.17402588
10MP0002653_abnormal_ependyma_morphology2.11538096
11MP0006036_abnormal_mitochondrial_physio2.11257820
12MP0001529_abnormal_vocalization2.07237063
13MP0003718_maternal_effect2.05441113
14MP0005084_abnormal_gallbladder_morpholo2.03082380
15MP0001984_abnormal_olfaction2.00618585
16MP0003186_abnormal_redox_activity1.99342457
17MP0006072_abnormal_retinal_apoptosis1.97135922
18MP0003011_delayed_dark_adaptation1.95704309
19MP0003880_abnormal_central_pattern1.93144326
20MP0002736_abnormal_nociception_after1.88912682
21MP0005645_abnormal_hypothalamus_physiol1.88229421
22MP0002938_white_spotting1.85962752
23MP0008995_early_reproductive_senescence1.78309631
24MP0002638_abnormal_pupillary_reflex1.77283367
25MP0005551_abnormal_eye_electrophysiolog1.66671537
26MP0008872_abnormal_physiological_respon1.66126927
27MP0005253_abnormal_eye_physiology1.65517516
28MP0004147_increased_porphyrin_level1.63839925
29MP0004142_abnormal_muscle_tone1.62735178
30MP0005646_abnormal_pituitary_gland1.62333065
31MP0010094_abnormal_chromosome_stability1.60838488
32MP0008875_abnormal_xenobiotic_pharmacok1.58869285
33MP0006276_abnormal_autonomic_nervous1.57630837
34MP0003786_premature_aging1.57018571
35MP0001968_abnormal_touch/_nociception1.54401921
36MP0009046_muscle_twitch1.52003595
37MP0002277_abnormal_respiratory_mucosa1.50317698
38MP0006035_abnormal_mitochondrial_morpho1.47169337
39MP0004957_abnormal_blastocyst_morpholog1.40923462
40MP0009697_abnormal_copulation1.40490930
41MP0001485_abnormal_pinna_reflex1.39068594
42MP0005379_endocrine/exocrine_gland_phen1.38420865
43MP0008789_abnormal_olfactory_epithelium1.34972185
44MP0004043_abnormal_pH_regulation1.34778287
45MP0004215_abnormal_myocardial_fiber1.32202759
46MP0002160_abnormal_reproductive_system1.27303424
47MP0009745_abnormal_behavioral_response1.24731499
48MP0010386_abnormal_urinary_bladder1.24460303
49MP0002163_abnormal_gland_morphology1.22593285
50MP0002272_abnormal_nervous_system1.20679920
51MP0004133_heterotaxia1.19685460
52MP0003787_abnormal_imprinting1.16964886
53MP0000631_abnormal_neuroendocrine_gland1.16172144
54MP0001905_abnormal_dopamine_level1.14567623
55MP0001764_abnormal_homeostasis1.13314958
56MP0002234_abnormal_pharynx_morphology1.09630425
57MP0002822_catalepsy1.07943687
58MP0002751_abnormal_autonomic_nervous1.07900433
59MP0009379_abnormal_foot_pigmentation1.07344606
60MP0002876_abnormal_thyroid_physiology1.07043116
61MP0001293_anophthalmia1.06679295
62MP0005410_abnormal_fertilization1.05027329
63MP0002132_abnormal_respiratory_system1.03967695
64MP0002210_abnormal_sex_determination1.01024564
65MP0001486_abnormal_startle_reflex0.98394043
66MP0001929_abnormal_gametogenesis0.97806010
67MP0005367_renal/urinary_system_phenotyp0.97685955
68MP0000516_abnormal_urinary_system0.97685955
69MP0005332_abnormal_amino_acid0.97585846
70MP0003693_abnormal_embryo_hatching0.96999466
71MP0008932_abnormal_embryonic_tissue0.95126238
72MP0003890_abnormal_embryonic-extraembry0.94901724
73MP0003122_maternal_imprinting0.94778889
74MP0005636_abnormal_mineral_homeostasis0.93616906
75MP0003121_genomic_imprinting0.92949779
76MP0002090_abnormal_vision0.91920013
77MP0005389_reproductive_system_phenotype0.91860451
78MP0003698_abnormal_male_reproductive0.91252818
79MP0002282_abnormal_trachea_morphology0.90565499
80MP0005085_abnormal_gallbladder_physiolo0.89754017
81MP0000653_abnormal_sex_gland0.89439562
82MP0002735_abnormal_chemical_nociception0.88953554
83MP0001970_abnormal_pain_threshold0.88772167
84MP0000647_abnormal_sebaceous_gland0.86684206
85MP0008004_abnormal_stomach_pH0.86557035
86MP0005187_abnormal_penis_morphology0.85481104
87MP0005394_taste/olfaction_phenotype0.84154808
88MP0005499_abnormal_olfactory_system0.84154808
89MP0001145_abnormal_male_reproductive0.83882353
90MP0002734_abnormal_mechanical_nocicepti0.82830976
91MP0003137_abnormal_impulse_conducting0.80751810
92MP0002909_abnormal_adrenal_gland0.80161322
93MP0001756_abnormal_urination0.79570188
94MP0001501_abnormal_sleep_pattern0.78237252
95MP0002557_abnormal_social/conspecific_i0.78082096
96MP0000358_abnormal_cell_content/0.77311142
97MP0005195_abnormal_posterior_eye0.76902581
98MP0004019_abnormal_vitamin_homeostasis0.76341382
99MP0003077_abnormal_cell_cycle0.75813019
100MP0002233_abnormal_nose_morphology0.73170156

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.04658965
2Abnormal mitochondria in muscle tissue (HP:0008316)4.44213652
3Mitochondrial inheritance (HP:0001427)4.44096478
4Progressive macrocephaly (HP:0004481)4.36107007
5Acute encephalopathy (HP:0006846)4.32239281
6Increased CSF lactate (HP:0002490)4.04086589
7Hepatocellular necrosis (HP:0001404)3.89023772
8Increased hepatocellular lipid droplets (HP:0006565)3.67594623
9Hepatic necrosis (HP:0002605)3.65857632
10Pancreatic cysts (HP:0001737)3.53770748
11Abnormal ciliary motility (HP:0012262)3.48311767
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.44540724
13Lipid accumulation in hepatocytes (HP:0006561)3.42240218
14Abnormal respiratory motile cilium physiology (HP:0012261)3.39094776
15Renal Fanconi syndrome (HP:0001994)3.35400888
16Pancreatic fibrosis (HP:0100732)3.30415137
17Abnormal respiratory motile cilium morphology (HP:0005938)3.29212005
18Abnormal respiratory epithelium morphology (HP:0012253)3.29212005
193-Methylglutaconic aciduria (HP:0003535)3.27844343
20Absent/shortened dynein arms (HP:0200106)3.27373667
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.27373667
22True hermaphroditism (HP:0010459)3.24362747
23Cerebral edema (HP:0002181)3.20014149
24Molar tooth sign on MRI (HP:0002419)3.04342846
25Abnormality of midbrain morphology (HP:0002418)3.04342846
26Rhinitis (HP:0012384)3.03274376
27Medial flaring of the eyebrow (HP:0010747)2.93288168
28Methylmalonic acidemia (HP:0002912)2.81821614
29Nephronophthisis (HP:0000090)2.81227947
30Congenital, generalized hypertrichosis (HP:0004540)2.76845514
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70144832
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70144832
33Methylmalonic aciduria (HP:0012120)2.65692158
34Respiratory failure (HP:0002878)2.65510931
35Lactic acidosis (HP:0003128)2.59127091
36Increased serum lactate (HP:0002151)2.58386244
37Exertional dyspnea (HP:0002875)2.57769531
38Optic disc pallor (HP:0000543)2.42955101
39Congenital primary aphakia (HP:0007707)2.39289865
40Abnormality of renal resorption (HP:0011038)2.38653317
41Leukodystrophy (HP:0002415)2.36336682
42Gait imbalance (HP:0002141)2.35993018
43Nephrogenic diabetes insipidus (HP:0009806)2.35322270
44Hypothermia (HP:0002045)2.33150301
45Abnormality of the renal medulla (HP:0100957)2.27718216
46Colon cancer (HP:0003003)2.25225795
47Abnormality of urine glucose concentration (HP:0011016)2.25035727
48Glycosuria (HP:0003076)2.25035727
49Exercise intolerance (HP:0003546)2.24574117
50Chronic bronchitis (HP:0004469)2.22372700
51Sclerocornea (HP:0000647)2.22259798
52Intestinal atresia (HP:0011100)2.21719323
53Increased intramyocellular lipid droplets (HP:0012240)2.21643903
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19502091
55Abnormality of the renal cortex (HP:0011035)2.19184688
56Lethargy (HP:0001254)2.16872755
57Male pseudohermaphroditism (HP:0000037)2.12013816
58Type I transferrin isoform profile (HP:0003642)2.07148589
59Abnormality of the labia minora (HP:0012880)2.03752563
60Large for gestational age (HP:0001520)2.03016192
61Genital tract atresia (HP:0001827)2.01509260
62Respiratory difficulties (HP:0002880)1.98808517
63CNS demyelination (HP:0007305)1.98633346
64Abnormal number of erythroid precursors (HP:0012131)1.95134927
65Abnormality of methionine metabolism (HP:0010901)1.94404066
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94193875
67Vaginal atresia (HP:0000148)1.90442614
68Abnormal drinking behavior (HP:0030082)1.90385730
69Polydipsia (HP:0001959)1.90385730
70Cystic liver disease (HP:0006706)1.88780964
71Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87899719
72X-linked dominant inheritance (HP:0001423)1.87795384
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.87590497
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.86714378
75Bronchiectasis (HP:0002110)1.84683850
76Generalized aminoaciduria (HP:0002909)1.82744156
77Renal cortical cysts (HP:0000803)1.81499700
78Hypomagnesemia (HP:0002917)1.81337428
79Abnormality of vitamin B metabolism (HP:0004340)1.81039704
80Congenital stationary night blindness (HP:0007642)1.78783793
81Short tibia (HP:0005736)1.78656137
82Postaxial foot polydactyly (HP:0001830)1.77382259
83Hyperinsulinemic hypoglycemia (HP:0000825)1.76219942
84Median cleft lip (HP:0000161)1.75301715
85Decreased central vision (HP:0007663)1.73979112
86Increased muscle lipid content (HP:0009058)1.72902004
87Abnormality of cells of the erythroid lineage (HP:0012130)1.72802073
88Macrocytic anemia (HP:0001972)1.72657568
89Abnormality of alanine metabolism (HP:0010916)1.72480112
90Hyperalaninemia (HP:0003348)1.72480112
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72480112
92Hypoglycemic coma (HP:0001325)1.71937801
93Progressive inability to walk (HP:0002505)1.70624014
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70186349
95Abnormal protein N-linked glycosylation (HP:0012347)1.70186349
96Abnormal protein glycosylation (HP:0012346)1.70186349
97Abnormal glycosylation (HP:0012345)1.70186349
98Aplasia/Hypoplasia of the fovea (HP:0008060)1.67924180
99Hypoplasia of the fovea (HP:0007750)1.67924180
100Congenital hepatic fibrosis (HP:0002612)1.67916738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.66281845
2VRK23.09690198
3MAP4K22.98287396
4FRK2.93008041
5TRIM282.89807919
6ZAK2.28222900
7WNK32.25991226
8STK162.22810158
9MAP3K122.06750895
10NME12.04818857
11VRK12.00527193
12BUB11.99524847
13BMPR1B1.96260031
14EIF2AK31.91937645
15PBK1.89514526
16EIF2AK11.87375985
17NEK11.85491646
18NUAK11.69669847
19STK38L1.66606185
20PLK31.65750584
21SRPK11.60351182
22GRK11.50469940
23MKNK21.48948496
24MKNK11.43962962
25PLK41.42723298
26CASK1.38951178
27MAPK151.37112175
28MAP3K41.34438879
29TLK11.26711595
30TNIK1.24673127
31WEE11.22604635
32CDC71.20234619
33DYRK21.19496193
34ADRBK21.17398563
35BCR1.17384777
36TTK1.16299280
37INSRR1.15820321
38PDK21.15458283
39TSSK61.12844269
40PLK21.12451891
41CSNK1G21.09163249
42MYLK1.08396954
43CSNK1G31.08303630
44CSNK1G11.06889520
45BRSK21.06357377
46ERBB31.05136905
47PHKG11.01344487
48PHKG21.01344487
49OXSR10.99501702
50MAPK130.96715183
51EPHA40.95560365
52MAP2K70.94366897
53ACVR1B0.92949750
54PLK10.90686247
55PAK30.90437887
56STK30.87058369
57STK390.83728294
58BCKDK0.82683468
59WNK40.74217577
60PNCK0.74172869
61DYRK30.73140129
62CSNK1A1L0.72191529
63PRKCG0.72126453
64PINK10.67054137
65PRKCE0.65982958
66CCNB10.63067462
67ILK0.60954417
68TAF10.58778692
69DAPK10.57728324
70ADRBK10.55565196
71MAPKAPK50.52320268
72TEC0.51203321
73EIF2AK20.50539873
74BMPR20.49382279
75CSNK2A10.49255182
76PASK0.47597444
77PTK2B0.47534111
78STK240.47527742
79PRKCI0.47320898
80RPS6KA50.46188621
81CSNK2A20.46015443
82CHEK20.46014937
83DAPK20.45985712
84ATR0.43492239
85AURKB0.43408665
86LIMK10.41884620
87MINK10.41718611
88CDK30.41111136
89CDK80.40697710
90CSNK1A10.40510120
91CDK190.38080806
92OBSCN0.38075171
93PRKG10.37753183
94CAMK2A0.37573186
95NTRK30.36815513
96GRK50.36288653
97TAOK30.36134366
98TGFBR10.35485895
99PRKACA0.35289748
100PKN10.34300673

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.31861523
2Proteasome_Homo sapiens_hsa030503.58719562
3Parkinsons disease_Homo sapiens_hsa050123.52887963
4Protein export_Homo sapiens_hsa030603.42661836
5Ribosome_Homo sapiens_hsa030102.82275288
6Huntingtons disease_Homo sapiens_hsa050162.71928530
7RNA polymerase_Homo sapiens_hsa030202.52314824
8Alzheimers disease_Homo sapiens_hsa050102.29993270
9Mismatch repair_Homo sapiens_hsa034302.24592435
10Homologous recombination_Homo sapiens_hsa034402.19158838
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94279847
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93683729
13Basal transcription factors_Homo sapiens_hsa030221.88900285
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87091332
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81560899
16Fanconi anemia pathway_Homo sapiens_hsa034601.77126087
17Cardiac muscle contraction_Homo sapiens_hsa042601.66988205
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65951907
19Propanoate metabolism_Homo sapiens_hsa006401.62596510
20Fatty acid elongation_Homo sapiens_hsa000621.60779326
21Nucleotide excision repair_Homo sapiens_hsa034201.59539432
22Collecting duct acid secretion_Homo sapiens_hsa049661.56636815
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54672080
24Glutathione metabolism_Homo sapiens_hsa004801.48746978
25DNA replication_Homo sapiens_hsa030301.43897804
26RNA degradation_Homo sapiens_hsa030181.43782359
27Butanoate metabolism_Homo sapiens_hsa006501.40256180
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.37613736
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33661678
30Pyrimidine metabolism_Homo sapiens_hsa002401.30387609
31Phototransduction_Homo sapiens_hsa047441.27808462
32Spliceosome_Homo sapiens_hsa030401.26715307
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21867904
34Purine metabolism_Homo sapiens_hsa002301.19296599
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18760544
36Folate biosynthesis_Homo sapiens_hsa007901.17919269
37Base excision repair_Homo sapiens_hsa034101.17336317
38One carbon pool by folate_Homo sapiens_hsa006701.11612482
39Chemical carcinogenesis_Homo sapiens_hsa052041.09825499
40Non-homologous end-joining_Homo sapiens_hsa034501.09276069
41beta-Alanine metabolism_Homo sapiens_hsa004101.07344096
42Peroxisome_Homo sapiens_hsa041461.06615817
43RNA transport_Homo sapiens_hsa030131.03216165
44Sulfur metabolism_Homo sapiens_hsa009201.03140343
45Nitrogen metabolism_Homo sapiens_hsa009101.02180760
46Pyruvate metabolism_Homo sapiens_hsa006200.99492158
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95486074
48Steroid biosynthesis_Homo sapiens_hsa001000.95182782
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89888204
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.89345543
51Tryptophan metabolism_Homo sapiens_hsa003800.89108762
52Linoleic acid metabolism_Homo sapiens_hsa005910.88437439
53Regulation of autophagy_Homo sapiens_hsa041400.87657509
54Metabolic pathways_Homo sapiens_hsa011000.86284283
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85356045
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83204619
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.82573152
58Retinol metabolism_Homo sapiens_hsa008300.78096824
59Selenocompound metabolism_Homo sapiens_hsa004500.75985896
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74799014
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72586524
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71843928
63Nicotine addiction_Homo sapiens_hsa050330.71806011
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71151063
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67890122
66Arachidonic acid metabolism_Homo sapiens_hsa005900.65697051
67Olfactory transduction_Homo sapiens_hsa047400.63729935
68Caffeine metabolism_Homo sapiens_hsa002320.61581155
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.59892781
70Fatty acid degradation_Homo sapiens_hsa000710.58850640
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57390738
72Oocyte meiosis_Homo sapiens_hsa041140.54940130
73Cell cycle_Homo sapiens_hsa041100.52829383
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51915491
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51791828
76Taste transduction_Homo sapiens_hsa047420.49080308
77Tyrosine metabolism_Homo sapiens_hsa003500.48673981
78Serotonergic synapse_Homo sapiens_hsa047260.47980718
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.47359247
80Ether lipid metabolism_Homo sapiens_hsa005650.46666247
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46151600
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42906815
83Fatty acid metabolism_Homo sapiens_hsa012120.42035716
84GABAergic synapse_Homo sapiens_hsa047270.41204134
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40038040
86Circadian rhythm_Homo sapiens_hsa047100.38319360
87Insulin secretion_Homo sapiens_hsa049110.36246090
88Arginine and proline metabolism_Homo sapiens_hsa003300.35111267
89Vibrio cholerae infection_Homo sapiens_hsa051100.34311621
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34058851
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33259120
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31858199
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31505141
94Mineral absorption_Homo sapiens_hsa049780.30011112
95Morphine addiction_Homo sapiens_hsa050320.29709999
96Synaptic vesicle cycle_Homo sapiens_hsa047210.28927051
97Vitamin digestion and absorption_Homo sapiens_hsa049770.27734444
98p53 signaling pathway_Homo sapiens_hsa041150.25366554
99Circadian entrainment_Homo sapiens_hsa047130.24688604
100Histidine metabolism_Homo sapiens_hsa003400.24326550

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