FAM101A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.19327811
2Golgi transport vesicle coating (GO:0048200)8.19327811
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.39730182
4endocrine pancreas development (GO:0031018)5.99777689
5protein retention in ER lumen (GO:0006621)5.88462133
6COPII vesicle coating (GO:0048208)5.06660652
7peptide hormone processing (GO:0016486)4.90450822
8glandular epithelial cell differentiation (GO:0002067)4.88744521
9type B pancreatic cell development (GO:0003323)4.75237502
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.65901874
11insulin secretion (GO:0030073)4.64805623
12sequestering of metal ion (GO:0051238)4.59658710
13glandular epithelial cell development (GO:0002068)4.45482094
14calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.33857763
15signal peptide processing (GO:0006465)4.22423739
16exocrine pancreas development (GO:0031017)4.18286419
17ER overload response (GO:0006983)4.09805759
18positive regulation of insulin secretion (GO:0032024)3.92944601
19vesicle coating (GO:0006901)3.90580541
20regulation of guanylate cyclase activity (GO:0031282)3.81936276
21positive regulation of pseudopodium assembly (GO:0031274)3.69948332
22protein maturation by protein folding (GO:0022417)3.67825561
23activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.65921962
24inner ear receptor cell development (GO:0060119)3.64616735
25pancreas development (GO:0031016)3.64127569
26regulation of type B pancreatic cell apoptotic process (GO:2000674)3.63632332
27regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.63514783
28establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.60213341
29astrocyte differentiation (GO:0048708)3.59967204
30regulation of insulin secretion (GO:0050796)3.59838061
31keratan sulfate catabolic process (GO:0042340)3.58852980
32epithelial cell fate commitment (GO:0072148)3.55982203
33regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.51438493
34regulation of pseudopodium assembly (GO:0031272)3.51262576
35chondrocyte development (GO:0002063)3.50357256
36peptide hormone secretion (GO:0030072)3.48087866
37positive regulation of nuclease activity (GO:0032075)3.43753922
38receptor recycling (GO:0001881)3.43664645
39regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.40803209
40peptide secretion (GO:0002790)3.37735182
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37588911
42columnar/cuboidal epithelial cell development (GO:0002066)3.37087337
43endocardial cushion morphogenesis (GO:0003203)3.35279393
44positive regulation of gastrulation (GO:2000543)3.33076901
45regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.33074796
46receptor guanylyl cyclase signaling pathway (GO:0007168)3.33069162
47male sex determination (GO:0030238)3.31898484
48negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.24558667
49regulation of peptide hormone secretion (GO:0090276)3.23946656
50positive regulation of hormone biosynthetic process (GO:0046886)3.19911708
51dendritic spine organization (GO:0097061)3.19666224
52cranial nerve morphogenesis (GO:0021602)3.18644872
53chondrocyte proliferation (GO:0035988)3.18606141
54nitric oxide mediated signal transduction (GO:0007263)3.18374847
55regulation of peptide secretion (GO:0002791)3.18161621
56regulation of hexokinase activity (GO:1903299)3.13073962
57regulation of glucokinase activity (GO:0033131)3.13073962
58regulation of nuclease activity (GO:0032069)3.08836709
59cell migration in hindbrain (GO:0021535)3.06988422
60establishment or maintenance of apical/basal cell polarity (GO:0035088)3.04762162
61establishment or maintenance of bipolar cell polarity (GO:0061245)3.04762162
62endoplasmic reticulum unfolded protein response (GO:0030968)3.03209605
63cellular response to unfolded protein (GO:0034620)3.03132742
64intestinal absorption (GO:0050892)3.02813146
65positive regulation of peptide hormone secretion (GO:0090277)3.02634624
66regulation of glucocorticoid secretion (GO:2000849)2.98287962
67pharyngeal system development (GO:0060037)2.98127176
68cellular response to topologically incorrect protein (GO:0035967)2.97423953
69somite development (GO:0061053)2.95415938
70renal system process involved in regulation of blood volume (GO:0001977)2.95372259
71regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.94783604
72epithelial cell-cell adhesion (GO:0090136)2.94647336
73positive regulation of peptide secretion (GO:0002793)2.93723911
74regulation of autophagic vacuole assembly (GO:2000785)2.92989620
75regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.92942339
76regulation of calcium ion-dependent exocytosis (GO:0017158)2.91958800
77cell-cell junction maintenance (GO:0045217)2.90668924
78sex determination (GO:0007530)2.90503876
79negative regulation of osteoblast proliferation (GO:0033689)2.89357958
80positive regulation of guanylate cyclase activity (GO:0031284)2.88656070
81ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.87856293
823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.87684468
83purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.87684468
84pyrimidine nucleobase catabolic process (GO:0006208)2.87487490
85actin filament depolymerization (GO:0030042)2.87105590
86dendritic spine morphogenesis (GO:0060997)2.86347238
87regulation of hormone secretion (GO:0046883)2.84199816
88hormone secretion (GO:0046879)2.82781413
89cell junction maintenance (GO:0034331)2.82033162
90cellular response to prostaglandin stimulus (GO:0071379)2.81119435
91positive regulation of oligodendrocyte differentiation (GO:0048714)2.80013861
92negative regulation of glycoprotein biosynthetic process (GO:0010561)2.79985916
93protein N-linked glycosylation via asparagine (GO:0018279)2.79853277
94oligosaccharide biosynthetic process (GO:0009312)2.79396128
95detection of calcium ion (GO:0005513)2.79146463
96ER-nucleus signaling pathway (GO:0006984)2.78195439
97regulation of male gonad development (GO:2000018)2.77458563
98eye photoreceptor cell differentiation (GO:0001754)2.76843009
99photoreceptor cell differentiation (GO:0046530)2.76843009
100peptidyl-asparagine modification (GO:0018196)2.76300750
101regulation of corticosteroid hormone secretion (GO:2000846)2.76216340
102peptide transport (GO:0015833)2.75623589
103glomerular filtration (GO:0003094)2.73734817
104endocrine process (GO:0050886)2.73426710
105regulation of systemic arterial blood pressure by hormone (GO:0001990)2.73426710
106regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.73426710
107paraxial mesoderm development (GO:0048339)2.73394589
108negative regulation of insulin secretion (GO:0046676)2.71851923
109interleukin-1-mediated signaling pathway (GO:0070498)2.71245108
110gland morphogenesis (GO:0022612)2.70878175
111response to redox state (GO:0051775)2.70132423
112lactate metabolic process (GO:0006089)2.69217485
113renal filtration (GO:0097205)2.68916875
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.67116054
115axon extension involved in axon guidance (GO:0048846)2.67116054
116mesenchyme morphogenesis (GO:0072132)2.65872440
117mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.65778967
118cellular response to glucagon stimulus (GO:0071377)2.64982378
119cellular response to vitamin D (GO:0071305)2.64652080
120signal transduction involved in regulation of gene expression (GO:0023019)2.63919971
121hormone transport (GO:0009914)2.63428359
122positive regulation of glycogen biosynthetic process (GO:0045725)2.62412082
123peptidyl-proline hydroxylation (GO:0019511)2.61452394
124lung secretory cell differentiation (GO:0061140)2.59150007
125regulation of early endosome to late endosome transport (GO:2000641)2.59065163
126layer formation in cerebral cortex (GO:0021819)2.58029485
127regulation of peptide transport (GO:0090087)2.57056767
128regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.56582869
129protein heterotrimerization (GO:0070208)2.55734178
130magnesium ion transport (GO:0015693)2.55653778
131regulation of cGMP biosynthetic process (GO:0030826)2.55410077
132negative regulation of transcription by competitive promoter binding (GO:0010944)2.55246156
133nucleobase catabolic process (GO:0046113)2.54024193
134toxin metabolic process (GO:0009404)2.53701432
135protein N-linked glycosylation (GO:0006487)2.51360583
136regulation of systemic arterial blood pressure (GO:0003073)2.50656887
137smoothened signaling pathway (GO:0007224)2.50632357
138axonal fasciculation (GO:0007413)2.50421611
139positive regulation of hormone secretion (GO:0046887)2.50203125
140virion attachment to host cell (GO:0019062)2.49659060
141adhesion of symbiont to host cell (GO:0044650)2.49659060
142negative regulation of catenin import into nucleus (GO:0035414)2.49557755
143planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49145954
144positive regulation of bone mineralization (GO:0030501)2.48086751
145axon extension (GO:0048675)2.47505894
146regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46364005
147negative regulation of bone resorption (GO:0045779)2.46149798
148negative regulation of epidermis development (GO:0045683)2.45443012
149neuron fate specification (GO:0048665)2.45106338
150appendage development (GO:0048736)2.44085488
151limb development (GO:0060173)2.44085488
152response to hepatocyte growth factor (GO:0035728)2.42279952
153cellular response to hepatocyte growth factor stimulus (GO:0035729)2.42279952
154nucleoside diphosphate biosynthetic process (GO:0009133)2.42148751
155ER to Golgi vesicle-mediated transport (GO:0006888)2.41732988
156sulfate transmembrane transport (GO:1902358)2.41394606
157intra-Golgi vesicle-mediated transport (GO:0006891)2.41228364
158response to hexose (GO:0009746)2.41128688
159angiotensin maturation (GO:0002003)2.38046744
160ephrin receptor signaling pathway (GO:0048013)2.37887867
161cellular response to pH (GO:0071467)2.35062560
162regulation of cGMP metabolic process (GO:0030823)2.35029563
1634-hydroxyproline metabolic process (GO:0019471)2.34838878
164cellular response to BMP stimulus (GO:0071773)2.33717696
165response to BMP (GO:0071772)2.33717696
166cGMP biosynthetic process (GO:0006182)2.31625006
167labyrinthine layer development (GO:0060711)2.31359134
168cellular component maintenance (GO:0043954)2.30793090
169regulation of cholesterol homeostasis (GO:2000188)2.29915004
170positive regulation of Rho protein signal transduction (GO:0035025)2.29839122
171regulation of transforming growth factor beta1 production (GO:0032908)2.29401909
172cGMP-mediated signaling (GO:0019934)2.28383416
173camera-type eye morphogenesis (GO:0048593)2.27731583
174tight junction assembly (GO:0070830)2.27380902
175negative regulation of epidermal cell differentiation (GO:0045605)2.26445620
176regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.26281048
177barbed-end actin filament capping (GO:0051016)2.24557094
178lung-associated mesenchyme development (GO:0060484)2.24089410
179adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.23674883
180positive regulation of synapse assembly (GO:0051965)2.21394541
181positive regulation of cartilage development (GO:0061036)2.20661024
182neuron recognition (GO:0008038)2.19675039
183lymphangiogenesis (GO:0001946)2.19455390
184excretion (GO:0007588)2.18455897
185positive regulation of chondrocyte differentiation (GO:0032332)2.18403005
186dopamine receptor signaling pathway (GO:0007212)2.18347830
187NADH metabolic process (GO:0006734)2.18029005
188semaphorin-plexin signaling pathway (GO:0071526)2.17497625
189negative regulation of digestive system process (GO:0060457)2.16841808
190establishment of monopolar cell polarity (GO:0061162)2.16189025
191establishment or maintenance of monopolar cell polarity (GO:0061339)2.16189025
192cochlea morphogenesis (GO:0090103)2.15425879
193nucleotide-sugar biosynthetic process (GO:0009226)2.14335684
194neuron projection extension (GO:1990138)2.11757013
195establishment of tissue polarity (GO:0007164)2.11233846
196establishment of planar polarity (GO:0001736)2.11233846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.63156434
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.82029994
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.20388427
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.17711438
5DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.84605763
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.38371806
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32527351
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31804121
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26772687
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23886323
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.20855242
12ZNF263_19887448_ChIP-Seq_K562_Human2.14980845
13GBX2_23144817_ChIP-Seq_PC3_Human2.13197190
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08415220
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07889442
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06474400
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.03483586
18EZH2_22144423_ChIP-Seq_EOC_Human2.03368078
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99229182
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97508942
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.95679018
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95428937
23OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.89012218
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88531358
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88288815
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87915044
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82130414
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81038590
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.79048968
30NR3C1_23031785_ChIP-Seq_PC12_Mouse1.75351987
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74863205
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72017871
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70442701
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68708536
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.68498953
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68485092
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68485092
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68038428
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67691675
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67440456
41CTCF_27219007_Chip-Seq_Bcells_Human1.64030919
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63113705
43* GATA1_26923725_Chip-Seq_HPCs_Mouse1.57425866
44* DROSHA_22980978_ChIP-Seq_HELA_Human1.57092114
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55254448
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53561389
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53504741
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52321916
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49555884
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47453773
51LXR_22292898_ChIP-Seq_THP-1_Human1.46934777
52* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43849329
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.43523921
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.43304081
55REST_21632747_ChIP-Seq_MESCs_Mouse1.42840101
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42312951
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41627119
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40713058
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40544080
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40219404
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.37982037
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35561931
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34865509
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34836313
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34722526
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.34720211
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33685152
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32044541
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30884945
70* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30167199
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28040007
72GATA1_22025678_ChIP-Seq_K562_Human1.24329616
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23947410
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22987896
75RACK7_27058665_Chip-Seq_MCF-7_Human1.22931171
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.22095744
77ZNF274_21170338_ChIP-Seq_K562_Hela1.21615033
78IGF1R_20145208_ChIP-Seq_DFB_Human1.21495723
79STAT3_23295773_ChIP-Seq_U87_Human1.20883111
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20728607
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.20642697
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19748500
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19548066
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.19185442
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19044793
86CLOCK_20551151_ChIP-Seq_293T_Human1.17291699
87KDM2B_26808549_Chip-Seq_K562_Human1.16286179
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.15885956
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14347307
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14009982
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13874075
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.13567293
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13322850
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12953393
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12408746
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.12179028
97TET1_21490601_ChIP-Seq_MESCs_Mouse1.11304596
98SMAD4_21741376_ChIP-Seq_HESCs_Human1.10930733
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09722673
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07906010
101AR_19668381_ChIP-Seq_PC3_Human1.06774282
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05956353
103SMAD4_21799915_ChIP-Seq_A2780_Human1.05416073
104CJUN_26792858_Chip-Seq_BT549_Human1.04354075
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.03489828
106MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02917531
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02712043
108* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01109240
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00945177
110* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00871039
111* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00247215
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99551679
113GATA4_25053715_ChIP-Seq_YYC3_Human0.99250858
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99241091
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.99125492
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97817215
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97540398
118SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97524662
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97357722
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96910318
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96681171
122* TP53_22127205_ChIP-Seq_IMR90_Human0.96527763
123FLI1_21867929_ChIP-Seq_TH2_Mouse0.96131215
124* AHR_22903824_ChIP-Seq_MCF-7_Human0.95628864
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95240148
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95139655
127SOX2_20726797_ChIP-Seq_SW620_Human0.94942475
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.94725915
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94015982
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93915458
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93149526
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.92353009
133P300_19829295_ChIP-Seq_ESCs_Human0.92012444
134KLF5_25053715_ChIP-Seq_YYC3_Human0.91759088
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90900614
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90871611
137TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90730934
138REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90182218
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89796953
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89782012
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89023137
142* ARNT_22903824_ChIP-Seq_MCF-7_Human0.88701982
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.88425079
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.88055997
145RARB_27405468_Chip-Seq_BRAIN_Mouse0.87395464
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87392371
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87022064
148RUNX2_22187159_ChIP-Seq_PCA_Human0.86986562
149REST_18959480_ChIP-ChIP_MESCs_Mouse0.86569589
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86361230
151ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86084845
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86080428
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84731161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue4.39748523
2MP0002877_abnormal_melanocyte_morpholog4.28628409
3MP0003283_abnormal_digestive_organ4.27167102
4MP0002822_catalepsy3.46924208
5MP0001944_abnormal_pancreas_morphology3.22122107
6MP0009780_abnormal_chondrocyte_physiolo3.16038874
7MP0002909_abnormal_adrenal_gland3.10252141
8MP0010386_abnormal_urinary_bladder3.07926713
9MP0000678_abnormal_parathyroid_gland3.06802185
10MP0008004_abnormal_stomach_pH3.00650218
11MP0002693_abnormal_pancreas_physiology2.98667037
12MP0006072_abnormal_retinal_apoptosis2.96665345
13MP0004043_abnormal_pH_regulation2.75395662
14MP0000537_abnormal_urethra_morphology2.73045681
15MP0000003_abnormal_adipose_tissue2.65075106
16MP0003122_maternal_imprinting2.64697686
17MP0003195_calcinosis2.60554231
18MP0005220_abnormal_exocrine_pancreas2.58685896
19MP0005379_endocrine/exocrine_gland_phen2.54573965
20MP0003183_abnormal_peptide_metabolism2.52094277
21MP0005503_abnormal_tendon_morphology2.29821947
22MP0001664_abnormal_digestion2.20455198
23MP0010234_abnormal_vibrissa_follicle2.18773327
24MP0009379_abnormal_foot_pigmentation2.15612123
25MP0002896_abnormal_bone_mineralization1.89012810
26MP0005257_abnormal_intraocular_pressure1.84128798
27MP0004272_abnormal_basement_membrane1.82821143
28MP0001299_abnormal_eye_distance/1.82670600
29MP0010368_abnormal_lymphatic_system1.81909649
30MP0008438_abnormal_cutaneous_collagen1.81689568
31MP0004859_abnormal_synaptic_plasticity1.77530953
32MP0000462_abnormal_digestive_system1.74694760
33MP0004264_abnormal_extraembryonic_tissu1.74546619
34MP0002249_abnormal_larynx_morphology1.72755715
35MP0005645_abnormal_hypothalamus_physiol1.71586129
36MP0008961_abnormal_basal_metabolism1.65758303
37MP0003879_abnormal_hair_cell1.65489371
38MP0002938_white_spotting1.65284604
39MP0005275_abnormal_skin_tensile1.58267541
40MP0003941_abnormal_skin_development1.56937439
41MP0003385_abnormal_body_wall1.55800615
42MP0000778_abnormal_nervous_system1.55465880
43MP0004145_abnormal_muscle_electrophysio1.54122939
44MP0005253_abnormal_eye_physiology1.49151800
45MP0002078_abnormal_glucose_homeostasis1.48223531
46MP0002837_dystrophic_cardiac_calcinosis1.44939675
47MP0002234_abnormal_pharynx_morphology1.42719147
48MP0000631_abnormal_neuroendocrine_gland1.40670613
49MP0000163_abnormal_cartilage_morphology1.40016292
50MP0009840_abnormal_foam_cell1.39141258
51MP0003868_abnormal_feces_composition1.38285165
52MP0001270_distended_abdomen1.36462598
53MP0003938_abnormal_ear_development1.35060671
54MP0000613_abnormal_salivary_gland1.33653305
55MP0005085_abnormal_gallbladder_physiolo1.32047480
56MP0000751_myopathy1.30495419
57MP0001849_ear_inflammation1.27643051
58MP0000470_abnormal_stomach_morphology1.27284868
59MP0001958_emphysema1.26550370
60MP0002638_abnormal_pupillary_reflex1.26069944
61MP0004233_abnormal_muscle_weight1.25382551
62MP0005508_abnormal_skeleton_morphology1.24277621
63MP0000049_abnormal_middle_ear1.24081403
64MP0010030_abnormal_orbit_morphology1.23967291
65MP0003705_abnormal_hypodermis_morpholog1.23050973
66MP0005451_abnormal_body_composition1.22382464
67MP0002163_abnormal_gland_morphology1.21200329
68MP0002254_reproductive_system_inflammat1.20910763
69MP0002751_abnormal_autonomic_nervous1.20656095
70MP0001765_abnormal_ion_homeostasis1.19326415
71MP0001188_hyperpigmentation1.16797418
72MP0002653_abnormal_ependyma_morphology1.16481604
73MP0010352_gastrointestinal_tract_polyps1.14511710
74MP0003959_abnormal_lean_body1.14502528
75MP0001346_abnormal_lacrimal_gland1.12267016
76MP0002089_abnormal_postnatal_growth/wei1.11232637
77MP0003942_abnormal_urinary_system1.11137219
78MP0000428_abnormal_craniofacial_morphol1.10093692
79MP0002734_abnormal_mechanical_nocicepti1.09723858
80MP0002928_abnormal_bile_duct1.07915201
81MP0000538_abnormal_urinary_bladder1.06523121
82MP0003935_abnormal_craniofacial_develop1.05998337
83MP0004133_heterotaxia1.05898809
84MP0003787_abnormal_imprinting1.05298356
85MP0002876_abnormal_thyroid_physiology1.04709296
86MP0005381_digestive/alimentary_phenotyp1.03632843
87MP0002177_abnormal_outer_ear1.02489636
88MP0005375_adipose_tissue_phenotype1.01801524
89MP0001502_abnormal_circadian_rhythm1.01301132
90MP0002116_abnormal_craniofacial_bone1.00454833
91MP0005409_darkened_coat_color0.99773498
92MP0003119_abnormal_digestive_system0.99661326
93MP0002697_abnormal_eye_size0.99572876
94MP0004134_abnormal_chest_morphology0.99357532
95MP0002796_impaired_skin_barrier0.97473251
96MP0002139_abnormal_hepatobiliary_system0.96599289
97MP0003953_abnormal_hormone_level0.95773909
98MP0000477_abnormal_intestine_morphology0.95148955
99MP0005670_abnormal_white_adipose0.94924109
100MP0002233_abnormal_nose_morphology0.94919178
101MP0002933_joint_inflammation0.94716362
102MP0002108_abnormal_muscle_morphology0.93910062
103MP0002932_abnormal_joint_morphology0.91828821
104MP0003937_abnormal_limbs/digits/tail_de0.88694363
105MP0004782_abnormal_surfactant_physiolog0.88186486
106MP0006276_abnormal_autonomic_nervous0.87483661
107MP0002115_abnormal_skeleton_extremities0.87128905
108MP0005623_abnormal_meninges_morphology0.86759929
109MP0005360_urolithiasis0.85915087
110MP0000566_synostosis0.84891530
111MP0003300_gastrointestinal_ulcer0.84757826
112MP0005595_abnormal_vascular_smooth0.84398737
113MP0003635_abnormal_synaptic_transmissio0.84162671
114MP0002090_abnormal_vision0.83950996
115MP0000026_abnormal_inner_ear0.83822411
116MP0001756_abnormal_urination0.83170180
117MP0000230_abnormal_systemic_arterial0.82821789
118MP0005248_abnormal_Harderian_gland0.82742749
119MP0002733_abnormal_thermal_nociception0.82627062
120MP0005551_abnormal_eye_electrophysiolog0.81584476
121MP0005646_abnormal_pituitary_gland0.80645981
122MP0003795_abnormal_bone_structure0.80461998
123MP0003121_genomic_imprinting0.80407877
124MP0005501_abnormal_skin_physiology0.79479971
125MP0002109_abnormal_limb_morphology0.79374543
126MP0003861_abnormal_nervous_system0.79116375
127MP0003315_abnormal_perineum_morphology0.78759471
128MP0003755_abnormal_palate_morphology0.78321534
129MP0009250_abnormal_appendicular_skeleto0.78135901
130MP0002113_abnormal_skeleton_development0.77277239
131MP0001879_abnormal_lymphatic_vessel0.76772439
132MP0002127_abnormal_cardiovascular_syste0.76639830
133MP0000579_abnormal_nail_morphology0.75965895
134MP0002184_abnormal_innervation0.75289551
135MP0001666_abnormal_nutrient_absorption0.74961024
136MP0000750_abnormal_muscle_regeneration0.74307865
137MP0000490_abnormal_crypts_of0.74142771
138MP0000762_abnormal_tongue_morphology0.73878148
139MP0002114_abnormal_axial_skeleton0.73422711
140MP0000534_abnormal_ureter_morphology0.72518200
141MP0004270_analgesia0.71190454
142MP0004147_increased_porphyrin_level0.70766324
143MP0003123_paternal_imprinting0.70402782
144MP0002060_abnormal_skin_morphology0.70198616
145MP0003567_abnormal_fetal_cardiomyocyte0.70063501
146MP0000747_muscle_weakness0.69753546
147MP0009384_cardiac_valve_regurgitation0.69681727
148MP0001986_abnormal_taste_sensitivity0.68695030
149MP0003634_abnormal_glial_cell0.68159010
150MP0005187_abnormal_penis_morphology0.67910481
151MP0005391_vision/eye_phenotype0.66957070
152MP0000467_abnormal_esophagus_morphology0.66595477
153MP0001348_abnormal_lacrimal_gland0.66011210
154MP0003890_abnormal_embryonic-extraembry0.65052300
155MP0002098_abnormal_vibrissa_morphology0.64960575
156MP0002295_abnormal_pulmonary_circulatio0.64703733
157MP0000516_abnormal_urinary_system0.64283777
158MP0005367_renal/urinary_system_phenotyp0.64283777
159MP0000681_abnormal_thyroid_gland0.64185998
160MP0005390_skeleton_phenotype0.63311558
161MP0000749_muscle_degeneration0.63093290
162MP0003329_amyloid_beta_deposits0.62410552
163MP0002063_abnormal_learning/memory/cond0.61872292
164MP0009703_decreased_birth_body0.61842075
165MP0002111_abnormal_tail_morphology0.61520174
166MP0004858_abnormal_nervous_system0.61311653
167MP0003045_fibrosis0.61154282

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.36361438
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.05272454
3Hypoglycemic seizures (HP:0002173)4.78218038
4Abnormality of endocrine pancreas physiology (HP:0012093)4.28384231
5Abnormality of the pancreatic islet cells (HP:0006476)4.28384231
6Insulin-resistant diabetes mellitus (HP:0000831)4.18920567
7Abnormality of calcium-phosphate metabolism (HP:0100530)4.13841305
8Hyperglycemia (HP:0003074)4.12453080
9Decreased circulating renin level (HP:0003351)4.09192125
10Symptomatic seizures (HP:0011145)4.02964440
11Large for gestational age (HP:0001520)3.70757753
12Broad metatarsal (HP:0001783)3.52655761
13Pancreatic islet-cell hyperplasia (HP:0004510)3.49764678
14Hypoglycemic coma (HP:0001325)3.43520214
15Abnormal pancreas size (HP:0012094)3.39231206
16Epiphyseal dysplasia (HP:0002656)3.27774344
17Protrusio acetabuli (HP:0003179)3.18250163
18Irregular vertebral endplates (HP:0003301)3.01437143
19Ketoacidosis (HP:0001993)2.97167987
20Cervical subluxation (HP:0003308)2.93037622
21Small epiphyses (HP:0010585)2.88720633
22Hyperparathyroidism (HP:0000843)2.87512077
23Abnormality of polysaccharide metabolism (HP:0011012)2.87104614
24Abnormality of glycosaminoglycan metabolism (HP:0004371)2.87104614
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.87104614
26Renal tubular acidosis (HP:0001947)2.80296999
27Hyperkalemia (HP:0002153)2.76994586
28Hyperactive renin-angiotensin system (HP:0000841)2.75824762
29Agitation (HP:0000713)2.72474009
30Mucopolysacchariduria (HP:0008155)2.72370264
31Urinary glycosaminoglycan excretion (HP:0003541)2.72370264
32Disproportionate short-trunk short stature (HP:0003521)2.71638086
33Aortic dissection (HP:0002647)2.70841026
34Flat capital femoral epiphysis (HP:0003370)2.70287624
35Flat acetabular roof (HP:0003180)2.62197800
36Hypokalemia (HP:0002900)2.60611666
37Spinal rigidity (HP:0003306)2.60018808
38Sex reversal (HP:0012245)2.58952954
39Abnormal sex determination (HP:0012244)2.58952954
40Abnormality of the vertebral endplates (HP:0005106)2.58088190
41Soft skin (HP:0000977)2.56960851
42Atrophic scars (HP:0001075)2.55664964
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.54364279
44Coronal craniosynostosis (HP:0004440)2.47650309
45Thoracolumbar scoliosis (HP:0002944)2.46049432
46Abnormality of renin-angiotensin system (HP:0000847)2.45565092
47Abnormality of potassium homeostasis (HP:0011042)2.40650501
48Genu recurvatum (HP:0002816)2.40373742
49Ankle clonus (HP:0011448)2.38167076
50Hyperextensible skin (HP:0000974)2.35029811
51Bladder diverticulum (HP:0000015)2.34035807
52Bilateral sensorineural hearing impairment (HP:0008619)2.31736609
53Abnormality of proline metabolism (HP:0010907)2.29862777
54Hydroxyprolinuria (HP:0003080)2.29862777
55Late onset (HP:0003584)2.28467342
56Increased circulating renin level (HP:0000848)2.28387946
57Insulin resistance (HP:0000855)2.24026297
58Retinal atrophy (HP:0001105)2.23273893
59Mildly elevated creatine phosphokinase (HP:0008180)2.22835934
60Vertebral clefting (HP:0008428)2.21090875
61Abnormality of carpal bone ossification (HP:0006257)2.15877264
62Gout (HP:0001997)2.15072921
63Ulnar bowing (HP:0003031)2.14545287
64Type 1 muscle fiber predominance (HP:0003803)2.13996858
65Congenital glaucoma (HP:0001087)2.13386358
66Unilateral renal agenesis (HP:0000122)2.13236524
67Hypoplasia of the odontoid process (HP:0003311)2.12812403
68Shallow orbits (HP:0000586)2.12611727
69High anterior hairline (HP:0009890)2.12216746
70Macroorchidism (HP:0000053)2.10532429
71Abnormality of the vitamin B12 metabolism (HP:0004341)2.10069601
72Dysostosis multiplex (HP:0000943)2.09201303
73Abnormality of the distal phalanx of the thumb (HP:0009617)2.09092269
74Hypoplastic ischia (HP:0003175)2.08017089
75Wrist flexion contracture (HP:0001239)2.07301117
76Abnormality of dentin (HP:0010299)2.07042027
77Flattened epiphyses (HP:0003071)2.06890724
78Distal upper limb amyotrophy (HP:0007149)2.06812508
79Upper limb amyotrophy (HP:0009129)2.06812508
80Hepatoblastoma (HP:0002884)2.06361996
81Congenital sensorineural hearing impairment (HP:0008527)2.05128267
82Osteomalacia (HP:0002749)2.04649786
83Epileptiform EEG discharges (HP:0011182)2.04179539
84Menstrual irregularities (HP:0000858)2.02066161
85Hip contracture (HP:0003273)2.01958681
86EEG with generalized epileptiform discharges (HP:0011198)2.01844430
87Breech presentation (HP:0001623)2.01580699
88Hypoplasia of the fovea (HP:0007750)2.00975500
89Aplasia/Hypoplasia of the fovea (HP:0008060)2.00975500
90Platyspondyly (HP:0000926)2.00446609
91Malnutrition (HP:0004395)2.00303006
92Long toe (HP:0010511)1.99249765
93Hypercortisolism (HP:0001578)1.98085168
94Lumbar hyperlordosis (HP:0002938)1.97455588
95Abnormality of the 1st metacarpal (HP:0010009)1.97357469
96Myokymia (HP:0002411)1.95776221
97Focal segmental glomerulosclerosis (HP:0000097)1.95775250
98Conjugated hyperbilirubinemia (HP:0002908)1.92983519
99Bowing of the arm (HP:0006488)1.92405001
100Bowed forearm bones (HP:0003956)1.92405001
101Hypsarrhythmia (HP:0002521)1.91529851
102Abnormality of the aortic arch (HP:0012303)1.90247634
103Polyphagia (HP:0002591)1.89781540
104Abnormality of the phalanges of the hallux (HP:0010057)1.89714316
105Round ear (HP:0100830)1.89658650
106Missing ribs (HP:0000921)1.89448559
107Abnormality of the fovea (HP:0000493)1.89099269
108Adrenal overactivity (HP:0002717)1.88785916
109Neonatal short-limb short stature (HP:0008921)1.87820901
110Occipital encephalocele (HP:0002085)1.87315256
111Abnormality of the wing of the ilium (HP:0011867)1.87223993
112Difficulty climbing stairs (HP:0003551)1.86585298
113Limited hip movement (HP:0008800)1.86107335
114Abnormality of the proximal phalanges of the hand (HP:0009834)1.85718673
115Hypoplasia of the brainstem (HP:0002365)1.85535608
116Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85535608
117Hypoventilation (HP:0002791)1.85468176
118Abnormality of the ischium (HP:0003174)1.83493636
119Turricephaly (HP:0000262)1.83249441
120Lymphangioma (HP:0100764)1.82882708
121Symphalangism affecting the phalanges of the hand (HP:0009773)1.82717647
122Fragile skin (HP:0001030)1.82033875
123Protuberant abdomen (HP:0001538)1.81864015
124Rectal prolapse (HP:0002035)1.81656298
125Abnormality of vitamin B metabolism (HP:0004340)1.81638840
126Hyperphosphatemia (HP:0002905)1.80085295
127Metaphyseal cupping (HP:0003021)1.79873653
128Hyperaldosteronism (HP:0000859)1.79486665
129Abdominal distention (HP:0003270)1.78946060
130Flared iliac wings (HP:0002869)1.78659353
131Short nail (HP:0001799)1.78448178
132Beaking of vertebral bodies (HP:0004568)1.78179704
133Metabolic alkalosis (HP:0200114)1.78089689
134True hermaphroditism (HP:0010459)1.77495725
135Abnormality of magnesium homeostasis (HP:0004921)1.77249380
136Abnormality of the odontoid process (HP:0003310)1.75835005
137Severe short stature (HP:0003510)1.75698782
138Anteriorly placed anus (HP:0001545)1.75100759
139Enlarged penis (HP:0000040)1.74442581
140Coxa valga (HP:0002673)1.74304073
141Osteoarthritis (HP:0002758)1.74119405
142Cutaneous syndactyly (HP:0012725)1.74090986
143Premature rupture of membranes (HP:0001788)1.73618814
144Upper limb muscle weakness (HP:0003484)1.73186074
145Wide anterior fontanel (HP:0000260)1.72809794
146Exocrine pancreatic insufficiency (HP:0001738)1.72692049
147Abnormal ossification of hand bones (HP:0005921)1.71810436
148Hypoplastic labia majora (HP:0000059)1.71307051
149Anterior segment dysgenesis (HP:0007700)1.71005303
150Abnormal tarsal ossification (HP:0008369)1.70941476
151Muscle fiber splitting (HP:0003555)1.70572144
152Mild short stature (HP:0003502)1.69435264
153Myopathic facies (HP:0002058)1.68450095
154Septo-optic dysplasia (HP:0100842)1.68401018
155Bronchomalacia (HP:0002780)1.68138865
156Alkalosis (HP:0001948)1.67448197
157Abnormality of chloride homeostasis (HP:0011422)1.66993584
158Ovoid vertebral bodies (HP:0003300)1.66293485
159Spinal cord compression (HP:0002176)1.66220437
160Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.65736529
161Genu valgum (HP:0002857)1.65167144
162Abnormality of the middle phalanges of the toes (HP:0010183)1.65106376
163Growth hormone excess (HP:0000845)1.64803147
164Limb-girdle muscle weakness (HP:0003325)1.64624867
165Hypotension (HP:0002615)1.63634417
166Aplasia involving bones of the extremities (HP:0009825)1.63009713
167Aplasia involving bones of the upper limbs (HP:0009823)1.63009713
168Aplasia of the phalanges of the hand (HP:0009802)1.63009713
169Cutaneous finger syndactyly (HP:0010554)1.62698539
170Delayed epiphyseal ossification (HP:0002663)1.62616854
171Abnormality of molar (HP:0011077)1.62367351
172Abnormality of molar morphology (HP:0011070)1.62367351
173Hypothermia (HP:0002045)1.62061280
174Abnormality of the 2nd finger (HP:0004100)1.60958660
175Aortic aneurysm (HP:0004942)1.59911727
176Vitreoretinal degeneration (HP:0000655)1.59449511
177Nephrolithiasis (HP:0000787)1.59215000
178Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.58718343
179Short 4th metacarpal (HP:0010044)1.58160672
180Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.58160672
181Hand muscle atrophy (HP:0009130)1.57371756
182Buphthalmos (HP:0000557)1.55282044
183Aplasia/hypoplasia of the femur (HP:0005613)1.55233988
184Short palpebral fissure (HP:0012745)1.55099613
185Cerebral aneurysm (HP:0004944)1.54686025
186Morphological abnormality of the middle ear (HP:0008609)1.54278155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.95946565
2INSRR5.34257895
3WNK43.98593003
4CASK3.51252728
5FRK3.40994939
6PASK3.22434150
7EPHA32.65171218
8UHMK12.62422619
9WNK32.55066503
10OXSR12.50952525
11ERN12.48724567
12MAP3K22.32497817
13MAP3K102.27848169
14HIPK22.15158851
15LATS22.14615538
16LMTK22.07714834
17CDK192.06265976
18TAOK32.03422592
19IRAK12.00508732
20STK241.99810439
21PRKG21.94728300
22MST1R1.85819204
23NEK11.82257249
24PRKD31.73407304
25SIK31.71146223
26IRAK21.67965885
27MAP2K21.66431891
28PRPF4B1.62771494
29NME11.60973361
30WNK11.51843031
31EIF2AK31.50140271
32CDC42BPA1.48419029
33NLK1.42429545
34MYLK1.41881816
35ACVR1B1.38789896
36NTRK11.34838177
37SIK11.31561311
38PAK31.30864054
39MARK11.30720550
40LATS11.30571428
41TESK11.30192075
42TYRO31.27975448
43PDGFRA1.26405188
44SIK21.23546416
45FER1.20900417
46BCR1.19701467
47MOS1.14026344
48PTK21.12412219
49DYRK21.11649653
50STK161.08771311
51NTRK31.06179432
52PBK1.06136664
53DYRK1B1.05913685
54EPHB20.99978026
55MINK10.99173653
56BRD40.97634246
57DDR20.96656263
58STK38L0.96508940
59OBSCN0.96266075
60PINK10.94907727
61ZAK0.93248182
62MET0.91539571
63PHKG20.90239452
64PHKG10.90239452
65MAP3K10.87780787
66EPHB10.84037876
67MARK20.82693493
68IRAK30.82516265
69DYRK1A0.78881168
70AKT20.77018515
71PRKD20.76520085
72PRKCH0.76350308
73PTK60.75641394
74DAPK30.71863269
75MAP2K70.71844509
76STK380.70864538
77BMPR20.67981157
78EPHA40.67430072
79ICK0.66433441
80CDK140.66291216
81PRKCI0.65144133
82NEK60.64642947
83TTN0.64172284
84CDK11A0.63506871
85NTRK20.61796543
86CSNK1G30.60818709
87CDK80.60719467
88PRKCE0.60678654
89CDK150.60034483
90CDK180.59176305
91PAK40.57926143
92ILK0.57058963
93MTOR0.57057635
94ROCK10.57013682
95CHUK0.56614976
96RPS6KA40.55793557
97CAMKK20.55775873
98FGFR40.53552609
99DMPK0.53380057
100LIMK10.53047711
101CSNK1G20.52820299
102ERBB30.51430981
103ABL20.50491886
104ROCK20.48588199
105PRKAA10.48378029
106KSR10.45507593
107PRKCG0.45476631
108TRIB30.45450717
109BRSK20.44268514
110PRKCZ0.43555224
111STK30.43526847
112PDK20.43451673
113CSNK1A1L0.43059281
114CDK120.42521973
115CSNK1G10.41502439
116MUSK0.40834813
117CAMK2D0.40427887
118BRSK10.40422134
119NUAK10.40398958
120RET0.40389952
121MAP3K110.39497700
122MAP3K60.39307748
123PIK3CA0.38406929
124RIPK10.38406856
125MAP3K40.37903050
126BRAF0.37276224
127MAP2K10.36793856
128RPS6KA50.36429797
129BMPR1B0.36312476
130GSK3A0.36117436
131SRC0.35209250
132MAPK90.35079641
133PDGFRB0.35028788
134TIE10.34769896
135CAMK2G0.34411640
136YES10.33675626
137CAMK40.32459027
138PAK10.32175969
139CSNK1A10.31947133
140PRKD10.29866988
141TNIK0.28770884
142BMX0.28717502
143EPHA20.28707110
144CAMK2B0.28485144
145PRKAA20.27755003
146MAPK100.27481469
147STK390.26298934
148CDK50.26066883
149IGF1R0.24790606
150AKT10.24168192
151SGK2230.24028997
152SGK4940.24028997
153ERBB20.23935180
154INSR0.23721641
155RPS6KA20.22887069
156FGFR30.22770521

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.53386003
2Protein export_Homo sapiens_hsa030604.81578041
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.45584243
4Insulin secretion_Homo sapiens_hsa049113.20493409
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.74098195
6Sulfur metabolism_Homo sapiens_hsa009202.46518888
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25057353
8Vibrio cholerae infection_Homo sapiens_hsa051102.21927835
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08147543
10Fat digestion and absorption_Homo sapiens_hsa049752.07814907
11Cocaine addiction_Homo sapiens_hsa050301.95471003
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90805386
13Tight junction_Homo sapiens_hsa045301.89932686
14Vitamin digestion and absorption_Homo sapiens_hsa049771.85347726
15N-Glycan biosynthesis_Homo sapiens_hsa005101.81073820
16Type II diabetes mellitus_Homo sapiens_hsa049301.80109217
17Mineral absorption_Homo sapiens_hsa049781.69125953
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.67868108
19Fructose and mannose metabolism_Homo sapiens_hsa000511.67296994
20Arginine and proline metabolism_Homo sapiens_hsa003301.66345174
21Circadian rhythm_Homo sapiens_hsa047101.62488555
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60484571
23Arginine biosynthesis_Homo sapiens_hsa002201.49887784
24Nitrogen metabolism_Homo sapiens_hsa009101.45883019
25Sulfur relay system_Homo sapiens_hsa041221.42674664
26Type I diabetes mellitus_Homo sapiens_hsa049401.37391997
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35345224
28Amphetamine addiction_Homo sapiens_hsa050311.35165088
29Circadian entrainment_Homo sapiens_hsa047131.33598144
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31396791
31Protein digestion and absorption_Homo sapiens_hsa049741.30960909
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29852285
33Renin-angiotensin system_Homo sapiens_hsa046141.28190056
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26628811
35Lysosome_Homo sapiens_hsa041421.21691543
36Other glycan degradation_Homo sapiens_hsa005111.20604305
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20309229
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17462931
39Sphingolipid metabolism_Homo sapiens_hsa006001.16330368
40GABAergic synapse_Homo sapiens_hsa047271.13936809
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13874977
42Cholinergic synapse_Homo sapiens_hsa047251.13513922
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12273601
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11888974
45Morphine addiction_Homo sapiens_hsa050321.10923562
46Serotonergic synapse_Homo sapiens_hsa047261.08846540
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08212586
48Thyroid hormone synthesis_Homo sapiens_hsa049181.07640449
49Bile secretion_Homo sapiens_hsa049761.07581569
50Dopaminergic synapse_Homo sapiens_hsa047281.06608270
51ECM-receptor interaction_Homo sapiens_hsa045121.06138125
52Steroid biosynthesis_Homo sapiens_hsa001001.00370617
53Synaptic vesicle cycle_Homo sapiens_hsa047210.99741935
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98900065
55Retinol metabolism_Homo sapiens_hsa008300.98517234
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97312995
57Hedgehog signaling pathway_Homo sapiens_hsa043400.94090928
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94013566
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93200612
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90806096
61Taste transduction_Homo sapiens_hsa047420.90193983
62Galactose metabolism_Homo sapiens_hsa000520.88694944
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86635082
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85168825
65Gastric acid secretion_Homo sapiens_hsa049710.83737642
66Estrogen signaling pathway_Homo sapiens_hsa049150.83272492
67Caffeine metabolism_Homo sapiens_hsa002320.83083167
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80892002
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80598097
70Glucagon signaling pathway_Homo sapiens_hsa049220.79463966
71Pancreatic secretion_Homo sapiens_hsa049720.79040622
72Dilated cardiomyopathy_Homo sapiens_hsa054140.78496727
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77635254
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76339394
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75836588
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.72538640
77Prion diseases_Homo sapiens_hsa050200.69159160
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67347309
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67316171
80Alcoholism_Homo sapiens_hsa050340.66854674
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66836579
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66420633
83Wnt signaling pathway_Homo sapiens_hsa043100.64330682
84Cardiac muscle contraction_Homo sapiens_hsa042600.64142913
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.63314064
86Collecting duct acid secretion_Homo sapiens_hsa049660.63105888
87Melanogenesis_Homo sapiens_hsa049160.62831650
88Selenocompound metabolism_Homo sapiens_hsa004500.62447484
89Chemical carcinogenesis_Homo sapiens_hsa052040.62410069
90cAMP signaling pathway_Homo sapiens_hsa040240.62004834
91Biosynthesis of amino acids_Homo sapiens_hsa012300.61540511
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61536904
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61203846
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60851500
95Histidine metabolism_Homo sapiens_hsa003400.60200442
96Insulin resistance_Homo sapiens_hsa049310.60053149
97Glutamatergic synapse_Homo sapiens_hsa047240.59095297
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58141740
99Prolactin signaling pathway_Homo sapiens_hsa049170.57676011
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56671824
101Bladder cancer_Homo sapiens_hsa052190.56603970
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.56467056
103Prostate cancer_Homo sapiens_hsa052150.56046592
104Focal adhesion_Homo sapiens_hsa045100.55575751
105Folate biosynthesis_Homo sapiens_hsa007900.54779343
106Carbon metabolism_Homo sapiens_hsa012000.53531041
107Axon guidance_Homo sapiens_hsa043600.52973308
108Renin secretion_Homo sapiens_hsa049240.52207642
109PPAR signaling pathway_Homo sapiens_hsa033200.52206521
110Notch signaling pathway_Homo sapiens_hsa043300.51140862
111Long-term potentiation_Homo sapiens_hsa047200.50952762
112Long-term depression_Homo sapiens_hsa047300.50525889
113Gap junction_Homo sapiens_hsa045400.50463554
114Ovarian steroidogenesis_Homo sapiens_hsa049130.50293382
115Basal cell carcinoma_Homo sapiens_hsa052170.49649462
116Regulation of autophagy_Homo sapiens_hsa041400.48816069
117ABC transporters_Homo sapiens_hsa020100.47973062
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47868828
119Adherens junction_Homo sapiens_hsa045200.46750654
120Phagosome_Homo sapiens_hsa041450.46538354
121Nicotine addiction_Homo sapiens_hsa050330.46079704
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45480648
123Phenylalanine metabolism_Homo sapiens_hsa003600.44600831
124Salmonella infection_Homo sapiens_hsa051320.44481282
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43650701
126Amoebiasis_Homo sapiens_hsa051460.42662894
127Proteoglycans in cancer_Homo sapiens_hsa052050.42541639
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41649459
129AMPK signaling pathway_Homo sapiens_hsa041520.41050661
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40074803
131Starch and sucrose metabolism_Homo sapiens_hsa005000.39974355
132Oxytocin signaling pathway_Homo sapiens_hsa049210.38935532
133Melanoma_Homo sapiens_hsa052180.38716719
134Insulin signaling pathway_Homo sapiens_hsa049100.38703225
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38627256
136Renal cell carcinoma_Homo sapiens_hsa052110.38491504
137Thyroid cancer_Homo sapiens_hsa052160.38323891
138GnRH signaling pathway_Homo sapiens_hsa049120.38116705
139Ras signaling pathway_Homo sapiens_hsa040140.35728921
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34550173
141Hippo signaling pathway_Homo sapiens_hsa043900.34215762
142Linoleic acid metabolism_Homo sapiens_hsa005910.33807367
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33695800
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.32972965
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31014376
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30951412
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30065012

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