FAIM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.68925074
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.61475233
3locomotory exploration behavior (GO:0035641)5.72676724
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.61899916
5synaptic vesicle exocytosis (GO:0016079)5.61740070
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.61095992
7glutamate secretion (GO:0014047)5.48881630
8regulation of synaptic vesicle exocytosis (GO:2000300)5.32347020
9vocalization behavior (GO:0071625)5.24349927
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.12536956
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.07211227
12neuronal action potential propagation (GO:0019227)4.91418701
13neurotransmitter secretion (GO:0007269)4.84516510
14regulation of glutamate receptor signaling pathway (GO:1900449)4.81413264
15cellular potassium ion homeostasis (GO:0030007)4.80894333
16regulation of synaptic vesicle transport (GO:1902803)4.76957186
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.72740352
18amino acid import (GO:0043090)4.63124726
19regulation of neuronal synaptic plasticity (GO:0048168)4.57117365
20sodium ion export (GO:0071436)4.54293953
21axon ensheathment in central nervous system (GO:0032291)4.46730653
22central nervous system myelination (GO:0022010)4.46730653
23protein localization to synapse (GO:0035418)4.45892887
24exploration behavior (GO:0035640)4.41029754
25neuromuscular process controlling posture (GO:0050884)4.39207968
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.38090304
27gamma-aminobutyric acid transport (GO:0015812)4.33262606
28neuron cell-cell adhesion (GO:0007158)4.19319257
29glutamate receptor signaling pathway (GO:0007215)4.18404427
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17293861
31synaptic transmission, glutamatergic (GO:0035249)4.16653239
32positive regulation of dendritic spine development (GO:0060999)4.07801236
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07069147
34long-term memory (GO:0007616)4.05923444
35neurotransmitter-gated ion channel clustering (GO:0072578)4.04191327
36neurotransmitter transport (GO:0006836)4.02650274
37regulation of synapse structural plasticity (GO:0051823)4.00314210
38regulation of voltage-gated calcium channel activity (GO:1901385)3.99619720
39proline transport (GO:0015824)3.98475913
40neuron-neuron synaptic transmission (GO:0007270)3.96935210
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.91355098
42regulation of synapse maturation (GO:0090128)3.90470358
43glycine transport (GO:0015816)3.90011699
44layer formation in cerebral cortex (GO:0021819)3.89301336
45negative regulation of dendrite morphogenesis (GO:0050774)3.80602272
46positive regulation of neurotransmitter secretion (GO:0001956)3.77611401
47positive regulation of membrane potential (GO:0045838)3.77236727
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.75352326
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.75062423
50activation of protein kinase A activity (GO:0034199)3.70330964
51regulation of neurotransmitter levels (GO:0001505)3.68841153
52cell communication by electrical coupling (GO:0010644)3.65523699
53synaptic vesicle endocytosis (GO:0048488)3.62601657
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.59784227
55dendritic spine morphogenesis (GO:0060997)3.59528100
56regulation of synaptic plasticity (GO:0048167)3.58510916
57regulation of postsynaptic membrane potential (GO:0060078)3.58244451
58regulation of neurotransmitter secretion (GO:0046928)3.57344207
59neurotransmitter uptake (GO:0001504)3.54829865
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.53863431
61acidic amino acid transport (GO:0015800)3.53038204
62neuromuscular process controlling balance (GO:0050885)3.50799405
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.50496656
64positive regulation of synapse maturation (GO:0090129)3.48362111
65long-term synaptic potentiation (GO:0060291)3.48044689
66L-amino acid import (GO:0043092)3.47172240
67regulation of dendritic spine development (GO:0060998)3.45200450
68potassium ion homeostasis (GO:0055075)3.43188025
69potassium ion import (GO:0010107)3.42092954
70transmission of nerve impulse (GO:0019226)3.42077348
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.40952402
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39560310
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.38203422
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.36333252
75regulation of neurotransmitter transport (GO:0051588)3.35740363
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.34590169
77mating behavior (GO:0007617)3.34414700
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32345013
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31300097
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29672638
81membrane depolarization during action potential (GO:0086010)3.29105245
82membrane hyperpolarization (GO:0060081)3.29005202
83regulation of vesicle fusion (GO:0031338)3.28577644
84cytoskeletal anchoring at plasma membrane (GO:0007016)3.24716519
85establishment of synaptic vesicle localization (GO:0097480)3.22849832
86synaptic vesicle transport (GO:0048489)3.22849832
87vesicle docking involved in exocytosis (GO:0006904)3.21759837
88neuron recognition (GO:0008038)3.20017707
89dendritic spine organization (GO:0097061)3.19756453
90cellular sodium ion homeostasis (GO:0006883)3.19043576
91response to auditory stimulus (GO:0010996)3.18709796
92membrane depolarization (GO:0051899)3.17651476
93neuromuscular synaptic transmission (GO:0007274)3.16750352
94adult walking behavior (GO:0007628)3.13241894
95L-glutamate transport (GO:0015813)3.12524905
96positive regulation of neurotransmitter transport (GO:0051590)3.11778218
97cell communication involved in cardiac conduction (GO:0086065)3.11548179
98regulation of dendritic spine morphogenesis (GO:0061001)3.11429809
99vesicle transport along microtubule (GO:0047496)3.11067386
100G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10653818
101regulation of synaptic transmission (GO:0050804)3.09987660
102* cerebellar Purkinje cell differentiation (GO:0021702)3.09876936
103chemosensory behavior (GO:0007635)3.09202219
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.08926549
105auditory behavior (GO:0031223)3.08547858
106synaptic transmission (GO:0007268)3.08281619
107neuronal ion channel clustering (GO:0045161)3.07645842
108positive regulation of synaptic transmission (GO:0050806)3.07517137
109prepulse inhibition (GO:0060134)3.06133682
110cerebellar granule cell differentiation (GO:0021707)3.05725445
111regulation of exocytosis (GO:0017157)3.05704707
112neuromuscular process (GO:0050905)3.04995613
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04769535
114detection of calcium ion (GO:0005513)3.04639251
115dicarboxylic acid transport (GO:0006835)3.02164490
116dendrite morphogenesis (GO:0048813)3.01243326
117signal release (GO:0023061)3.00236724
118positive regulation of potassium ion transmembrane transport (GO:1901381)3.00005433
119postsynaptic membrane organization (GO:0001941)2.99974387
120regulation of ARF protein signal transduction (GO:0032012)2.96604280
121behavioral defense response (GO:0002209)2.96536257
122behavioral fear response (GO:0001662)2.96536257
123response to histamine (GO:0034776)2.96316930
124axonal fasciculation (GO:0007413)2.95740951
125learning (GO:0007612)2.95598534
126innervation (GO:0060384)2.95468997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.90248373
2GBX2_23144817_ChIP-Seq_PC3_Human3.19160090
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17060440
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14684358
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99523636
6REST_21632747_ChIP-Seq_MESCs_Mouse2.83085144
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80852217
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80852217
9DROSHA_22980978_ChIP-Seq_HELA_Human2.75098073
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.71531321
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69076277
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63503839
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61197616
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60246237
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56651591
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44084856
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.43236444
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.39916962
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.37900594
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34392756
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.31107273
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.28992716
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25831152
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23452301
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.16806152
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10745265
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95514650
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88318827
29AR_21572438_ChIP-Seq_LNCaP_Human1.73095442
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.71993164
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71093667
32SMAD4_21799915_ChIP-Seq_A2780_Human1.54176031
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52640496
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51091977
35TAF15_26573619_Chip-Seq_HEK293_Human1.49100299
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43124854
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42477009
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40001410
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.34180106
40ZNF274_21170338_ChIP-Seq_K562_Hela1.27963865
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26100174
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24998919
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24659474
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.23345489
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21555355
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21533171
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21140630
48AR_19668381_ChIP-Seq_PC3_Human1.20346953
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18087224
50KDM2B_26808549_Chip-Seq_K562_Human1.17830049
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16491260
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16444563
53AR_25329375_ChIP-Seq_VCAP_Human1.15161389
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14053168
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.13966174
56P300_19829295_ChIP-Seq_ESCs_Human1.13742751
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12752562
58STAT3_23295773_ChIP-Seq_U87_Human1.12715487
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.11874680
60LXR_22292898_ChIP-Seq_THP-1_Human1.10843666
61* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10225061
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10114518
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.10083071
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09270345
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.09215301
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07085593
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06252171
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05691914
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05342910
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03887379
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.03671564
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.02859857
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02275948
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01537180
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01274947
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99606429
77TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99480089
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99376130
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98925171
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98777107
81* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98080713
82BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97976758
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97837613
84TCF4_23295773_ChIP-Seq_U87_Human0.97723791
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97355888
86* OCT4_19829295_ChIP-Seq_ESCs_Human0.96036918
87DPY_21335234_ChIP-Seq_ESCs_Mouse0.95989333
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94698969
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94349138
90SMC4_20622854_ChIP-Seq_HELA_Human0.93429409
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93379321
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.93362287
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93155057
94YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91786157
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.91054764
96TET1_21490601_ChIP-Seq_MESCs_Mouse0.90869656
97RNF2_27304074_Chip-Seq_NSC_Mouse0.90823670
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.90798760
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90514866
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.90506122
101CTCF_27219007_Chip-Seq_Bcells_Human0.90277124
102AHR_22903824_ChIP-Seq_MCF-7_Human0.89131803
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88187297
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87323172
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87018437
106* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86326356
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.85803118
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85611284
109KLF4_19829295_ChIP-Seq_ESCs_Human0.85551425
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85475651
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84740722
112RUNX2_22187159_ChIP-Seq_PCA_Human0.84294367
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83741553
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.83544283
115RXR_22108803_ChIP-Seq_LS180_Human0.83440182
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81411457
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81061224
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80934284
119SMAD4_21741376_ChIP-Seq_EPCs_Human0.80147832
120EGR1_19032775_ChIP-ChIP_M12_Human0.79792715
121MYC_19915707_ChIP-ChIP_AK7_Human0.79653985
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78692265
123* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.78631696
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77983752
125TP53_16413492_ChIP-PET_HCT116_Human0.77501118
126CREB1_26743006_Chip-Seq_LNCaP_Human0.77217842
127* SMAD4_21741376_ChIP-Seq_ESCs_Human0.73177183
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72216281
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.72066482
130KDM2B_26808549_Chip-Seq_DND41_Human0.71240782
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69967687
132TP53_23651856_ChIP-Seq_MEFs_Mouse0.69286280
133P68_20966046_ChIP-Seq_HELA_Human0.67781023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.63639208
2MP0003880_abnormal_central_pattern4.96526202
3MP0003635_abnormal_synaptic_transmissio4.25148143
4* MP0009745_abnormal_behavioral_response3.47474080
5MP0009046_muscle_twitch3.46538429
6MP0004270_analgesia3.45068828
7* MP0002064_seizures3.37562901
8MP0002063_abnormal_learning/memory/cond3.25896090
9MP0005423_abnormal_somatic_nervous3.01073680
10MP0002822_catalepsy3.00886526
11MP0001968_abnormal_touch/_nociception2.86244663
12MP0002272_abnormal_nervous_system2.84995841
13MP0002572_abnormal_emotion/affect_behav2.79969816
14MP0001486_abnormal_startle_reflex2.62905052
15MP0002734_abnormal_mechanical_nocicepti2.56653619
16MP0001501_abnormal_sleep_pattern2.51958622
17MP0008569_lethality_at_weaning2.20057261
18MP0002736_abnormal_nociception_after2.13768643
19MP0001440_abnormal_grooming_behavior2.05383512
20MP0002067_abnormal_sensory_capabilities2.02687744
21MP0003329_amyloid_beta_deposits1.98752988
22MP0001970_abnormal_pain_threshold1.94803801
23MP0002733_abnormal_thermal_nociception1.94657343
24MP0002735_abnormal_chemical_nociception1.94528149
25MP0001984_abnormal_olfaction1.80062360
26MP0002184_abnormal_innervation1.77357722
27MP0005646_abnormal_pituitary_gland1.77048473
28MP0004811_abnormal_neuron_physiology1.75856442
29MP0004858_abnormal_nervous_system1.74487134
30MP0002909_abnormal_adrenal_gland1.73297358
31MP0009780_abnormal_chondrocyte_physiolo1.72923848
32MP0002557_abnormal_social/conspecific_i1.68047160
33MP0004924_abnormal_behavior1.66991252
34MP0005386_behavior/neurological_phenoty1.66991252
35MP0003787_abnormal_imprinting1.63250184
36MP0004885_abnormal_endolymph1.60906642
37MP0003879_abnormal_hair_cell1.55847399
38MP0000955_abnormal_spinal_cord1.55147747
39MP0004142_abnormal_muscle_tone1.54336350
40MP0005645_abnormal_hypothalamus_physiol1.50413966
41MP0003633_abnormal_nervous_system1.50324294
42MP0003122_maternal_imprinting1.49016525
43MP0006276_abnormal_autonomic_nervous1.48916905
44MP0000778_abnormal_nervous_system1.46674183
45MP0002066_abnormal_motor_capabilities/c1.46445315
46MP0002882_abnormal_neuron_morphology1.42917322
47MP0001502_abnormal_circadian_rhythm1.37387685
48MP0001905_abnormal_dopamine_level1.31120669
49MP0003631_nervous_system_phenotype1.27820270
50MP0001529_abnormal_vocalization1.22919967
51MP0003690_abnormal_glial_cell1.18435111
52MP0002229_neurodegeneration1.13082508
53MP0000751_myopathy1.12573182
54MP0005551_abnormal_eye_electrophysiolog1.12341748
55MP0000920_abnormal_myelination1.11579735
56MP0008872_abnormal_physiological_respon1.11380694
57MP0004145_abnormal_muscle_electrophysio1.05839766
58MP0003075_altered_response_to1.05655985
59MP0004147_increased_porphyrin_level1.05205358
60MP0002152_abnormal_brain_morphology1.04357055
61MP0003632_abnormal_nervous_system0.97567323
62MP0003634_abnormal_glial_cell0.96066659
63MP0008874_decreased_physiological_sensi0.95057250
64MP0002069_abnormal_eating/drinking_beha0.92774554
65MP0000604_amyloidosis0.92525376
66MP0001177_atelectasis0.92223198
67MP0000013_abnormal_adipose_tissue0.91644190
68MP0004742_abnormal_vestibular_system0.90103895
69MP0001348_abnormal_lacrimal_gland0.89465599
70MP0003283_abnormal_digestive_organ0.88745429
71MP0001346_abnormal_lacrimal_gland0.86899751
72MP0010386_abnormal_urinary_bladder0.86838368
73MP0005394_taste/olfaction_phenotype0.85117082
74MP0005499_abnormal_olfactory_system0.85117082
75MP0005167_abnormal_blood-brain_barrier0.84556890
76MP0005535_abnormal_body_temperature0.83831600
77MP0001963_abnormal_hearing_physiology0.81027747
78MP0008961_abnormal_basal_metabolism0.80423233
79MP0002090_abnormal_vision0.80035219
80MP0005623_abnormal_meninges_morphology0.78867964
81MP0004085_abnormal_heartbeat0.77602862
82MP0004043_abnormal_pH_regulation0.77598008
83MP0003172_abnormal_lysosome_physiology0.77136857
84MP0001986_abnormal_taste_sensitivity0.77135484
85MP0002752_abnormal_somatic_nervous0.76574580
86MP0001485_abnormal_pinna_reflex0.72922967
87MP0008877_abnormal_DNA_methylation0.72418150
88MP0000569_abnormal_digit_pigmentation0.70955966
89MP0004215_abnormal_myocardial_fiber0.70037763
90MP0001188_hyperpigmentation0.69925227
91MP0004233_abnormal_muscle_weight0.68362588
92MP0003137_abnormal_impulse_conducting0.64364390
93MP0003123_paternal_imprinting0.62293983
94MP0002638_abnormal_pupillary_reflex0.60718800
95MP0004130_abnormal_muscle_cell0.59883676
96MP0000631_abnormal_neuroendocrine_gland0.59828978
97MP0001299_abnormal_eye_distance/0.58573664
98MP0000579_abnormal_nail_morphology0.57548422
99MP0000747_muscle_weakness0.57391457
100MP0004484_altered_response_of0.57202164
101MP0001664_abnormal_digestion0.55209882
102MP0010769_abnormal_survival0.54508202
103MP0005166_decreased_susceptibility_to0.53738841
104MP0001943_abnormal_respiration0.53463174
105MP0010770_preweaning_lethality0.51319338
106MP0002082_postnatal_lethality0.51319338
107MP0010768_mortality/aging0.50826163
108MP0003956_abnormal_body_size0.50428123
109MP0004510_myositis0.49900123
110MP0003121_genomic_imprinting0.45978090
111MP0005409_darkened_coat_color0.44555616
112MP0002873_normal_phenotype0.44259454
113MP0000026_abnormal_inner_ear0.43049895
114MP0003861_abnormal_nervous_system0.42721898
115MP0002169_no_abnormal_phenotype0.42592181

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.58353409
2Myokymia (HP:0002411)7.28056555
3Focal seizures (HP:0007359)5.76678054
4Visual hallucinations (HP:0002367)5.47704081
5Atonic seizures (HP:0010819)4.94716844
6Progressive cerebellar ataxia (HP:0002073)4.69066338
7Febrile seizures (HP:0002373)4.64366870
8Epileptic encephalopathy (HP:0200134)4.63570813
9Action tremor (HP:0002345)4.59354227
10Absence seizures (HP:0002121)4.37423068
11Supranuclear gaze palsy (HP:0000605)4.07223556
12Generalized tonic-clonic seizures (HP:0002069)4.06625936
13Dialeptic seizures (HP:0011146)3.96450456
14Ankle clonus (HP:0011448)3.78897367
15Cerebral hypomyelination (HP:0006808)3.70765115
16Depression (HP:0000716)3.58502708
17Dysdiadochokinesis (HP:0002075)3.54816480
18Postural instability (HP:0002172)3.53761798
19Gaze-evoked nystagmus (HP:0000640)3.49558471
20Dysmetria (HP:0001310)3.48205794
21Obstructive sleep apnea (HP:0002870)3.46754289
22Impaired vibration sensation in the lower limbs (HP:0002166)3.31971308
23Abnormal eating behavior (HP:0100738)3.26894030
24Anxiety (HP:0000739)3.22406411
25Mutism (HP:0002300)3.22246768
26Poor eye contact (HP:0000817)3.16125813
27Broad-based gait (HP:0002136)3.15596280
28Truncal ataxia (HP:0002078)3.13297460
29Hemiplegia (HP:0002301)3.12588595
30Urinary bladder sphincter dysfunction (HP:0002839)3.10077743
31Ventricular fibrillation (HP:0001663)3.06774366
32Intention tremor (HP:0002080)3.01795834
33Abnormality of the lower motor neuron (HP:0002366)3.00672639
34Torticollis (HP:0000473)2.94938610
35Impaired social interactions (HP:0000735)2.91644277
36Abnormal social behavior (HP:0012433)2.91644277
37Scanning speech (HP:0002168)2.88199047
38Akinesia (HP:0002304)2.84268281
39Spastic gait (HP:0002064)2.78204155
40Papilledema (HP:0001085)2.76178685
41Impaired smooth pursuit (HP:0007772)2.75078151
42Genetic anticipation (HP:0003743)2.74612433
43Urinary urgency (HP:0000012)2.70843563
44Focal dystonia (HP:0004373)2.69410818
45Bradykinesia (HP:0002067)2.64712420
46Dysmetric saccades (HP:0000641)2.64654712
47Hemiparesis (HP:0001269)2.61730703
48Neurofibrillary tangles (HP:0002185)2.59316285
49Abnormality of binocular vision (HP:0011514)2.56989687
50Diplopia (HP:0000651)2.56989687
51Apathy (HP:0000741)2.56490992
52Sleep apnea (HP:0010535)2.56197911
53Amblyopia (HP:0000646)2.55862348
54Progressive inability to walk (HP:0002505)2.53415753
55Abnormality of ocular smooth pursuit (HP:0000617)2.48561223
56Status epilepticus (HP:0002133)2.46265282
57Craniofacial dystonia (HP:0012179)2.42320501
58Hyperventilation (HP:0002883)2.40578282
59Choreoathetosis (HP:0001266)2.37670497
60Annular pancreas (HP:0001734)2.35829231
61Cerebral inclusion bodies (HP:0100314)2.34033857
62Pheochromocytoma (HP:0002666)2.33532261
63Spastic tetraparesis (HP:0001285)2.33472152
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.33368326
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.33368326
66Diminished motivation (HP:0000745)2.31277514
67CNS hypomyelination (HP:0003429)2.29549263
68Insomnia (HP:0100785)2.27897017
69Abnormality of saccadic eye movements (HP:0000570)2.25406150
70Drooling (HP:0002307)2.24644848
71Excessive salivation (HP:0003781)2.24644848
72Lower limb muscle weakness (HP:0007340)2.24016539
73Stereotypic behavior (HP:0000733)2.23246511
74Impaired vibratory sensation (HP:0002495)2.22923980
75Fetal akinesia sequence (HP:0001989)2.22413557
76Limb dystonia (HP:0002451)2.20814835
77Megalencephaly (HP:0001355)2.18615293
78Bundle branch block (HP:0011710)2.13836274
79Epileptiform EEG discharges (HP:0011182)2.13535899
80Clonus (HP:0002169)2.12051313
81Generalized myoclonic seizures (HP:0002123)2.11533926
82Morphological abnormality of the pyramidal tract (HP:0002062)2.11480383
83Agitation (HP:0000713)2.10445369
84Abnormality of the corticospinal tract (HP:0002492)2.08697363
85Abnormal EKG (HP:0003115)2.08108984
86Tetraplegia (HP:0002445)2.08062881
87Lower limb asymmetry (HP:0100559)2.08054077
88Neuronal loss in central nervous system (HP:0002529)2.06767630
89Incomplete penetrance (HP:0003829)2.06684117
90Increased circulating renin level (HP:0000848)2.06411447
91EEG with generalized epileptiform discharges (HP:0011198)2.05313155
92Pointed chin (HP:0000307)2.04457723
93Rigidity (HP:0002063)2.03641093
94Gait ataxia (HP:0002066)2.03336926
95Polyphagia (HP:0002591)1.98609906
96Neuroendocrine neoplasm (HP:0100634)1.97545749
97Lower limb amyotrophy (HP:0007210)1.95931195
98Spinal canal stenosis (HP:0003416)1.95775980
99Termporal pattern (HP:0011008)1.95669218
100Insidious onset (HP:0003587)1.95669218
101Peripheral hypomyelination (HP:0007182)1.95537951
102Delusions (HP:0000746)1.95014488
103Absent speech (HP:0001344)1.93752061
104Psychosis (HP:0000709)1.92829591
105Hypsarrhythmia (HP:0002521)1.92054022
106Memory impairment (HP:0002354)1.90755329
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89157072
108Rapidly progressive (HP:0003678)1.84583747
109Split foot (HP:0001839)1.82723985
110Aplasia involving bones of the extremities (HP:0009825)1.79874196
111Aplasia involving bones of the upper limbs (HP:0009823)1.79874196
112Aplasia of the phalanges of the hand (HP:0009802)1.79874196
113Unsteady gait (HP:0002317)1.77313806
114Slow progression (HP:0003677)1.76000975
115Postural tremor (HP:0002174)1.75317125
116Hypoventilation (HP:0002791)1.75135781
117Inability to walk (HP:0002540)1.74903739
118Anosmia (HP:0000458)1.74537185
119Heart block (HP:0012722)1.74383368
120Failure to thrive in infancy (HP:0001531)1.74310628
121Menstrual irregularities (HP:0000858)1.73414813
122Dementia (HP:0000726)1.72605151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.63984439
2MAP3K94.01605388
3EPHA43.78152040
4MAP3K42.93462506
5MINK12.61653320
6PAK62.59149856
7MAP2K72.36911786
8DAPK22.36540445
9PRKD32.20340795
10KSR22.17648512
11NTRK22.11049522
12MARK12.10897801
13MAP3K122.04199777
14CAMKK11.99365840
15MAP2K41.90322920
16NTRK11.85778981
17CDK191.82052902
18STK381.81097993
19ARAF1.74950969
20PRPF4B1.59890018
21MAP3K131.54504611
22CDK51.54379293
23GRK51.49133947
24RIPK41.38369765
25PLK21.37565423
26TNIK1.36780466
27CASK1.34563745
28UHMK11.34503494
29KSR11.30172800
30DAPK11.30112481
31PRKCG1.28038636
32CAMKK21.27787183
33FES1.25504849
34PINK11.21428406
35PRKCH1.17891089
36TYRO31.13516616
37SGK4941.12561852
38SGK2231.12561852
39PHKG11.10723047
40PHKG21.10723047
41CAMK11.10590117
42OXSR11.09639095
43LMTK21.09361264
44MAPK131.08570169
45PNCK1.03202744
46TNK21.01969024
47SIK21.01087540
48ALK0.99901473
49MAP3K20.98275342
50CAMK2A0.97813547
51TAOK10.97688536
52CDK180.96387549
53CDK150.96330921
54STK110.93023687
55CAMK2B0.92918111
56CDK140.90163427
57WNK10.89911327
58MAPK120.87228423
59CDK11A0.83733334
60PAK30.78260684
61SGK20.77839803
62SGK30.75643333
63PKN10.74564158
64PDK10.74515615
65RAF10.74141993
66MAP3K10.73256416
67LATS20.72406428
68RIPK10.72275595
69CAMK2G0.71511114
70PDPK10.71162211
71MAP3K110.70973835
72RET0.70202066
73NEK10.69424188
74LIMK10.68891751
75NEK60.68335293
76PTK2B0.66403421
77CAMK2D0.66151315
78MARK20.63492330
79DYRK1A0.63045429
80SGK10.62318632
81CDC42BPA0.60773425
82MAP3K70.55890892
83CSNK1G20.55237082
84BRSK10.53641144
85FGFR20.53161301
86RPS6KA30.52954710
87CAMK40.52258766
88CAMK1G0.51305763
89TESK10.49056515
90MAPK100.49045954
91FER0.48560406
92MAPKAPK50.48047188
93ROCK20.47113196
94DAPK30.46792975
95PRKCE0.43482620
96BMPR20.43418063
97PRKCZ0.43407120
98FYN0.42125433
99PRKG20.41842185
100BRAF0.40369260
101STK390.39023645
102MUSK0.33225577
103PRKCA0.32830506
104PRKCB0.32372845
105MAP2K10.32214101
106CCNB10.29831713
107ROCK10.29188747
108MOS0.28654840
109ERBB20.28144045
110BMX0.28040141
111PRKG10.26763506
112MAPK80.26276443
113SRC0.25362686
114MAP2K60.24038397
115JAK20.23030073

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82356419
2Synaptic vesicle cycle_Homo sapiens_hsa047213.65203797
3Olfactory transduction_Homo sapiens_hsa047402.99819551
4GABAergic synapse_Homo sapiens_hsa047272.90529693
5Circadian entrainment_Homo sapiens_hsa047132.68662092
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65522999
7Glutamatergic synapse_Homo sapiens_hsa047242.54645220
8Morphine addiction_Homo sapiens_hsa050322.54502712
9Long-term potentiation_Homo sapiens_hsa047202.45203434
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39424093
11Amphetamine addiction_Homo sapiens_hsa050312.30493395
12Salivary secretion_Homo sapiens_hsa049702.24352069
13Insulin secretion_Homo sapiens_hsa049112.09904920
14Dopaminergic synapse_Homo sapiens_hsa047282.03842105
15Gastric acid secretion_Homo sapiens_hsa049711.98677721
16Cholinergic synapse_Homo sapiens_hsa047251.84457921
17Taste transduction_Homo sapiens_hsa047421.79953383
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79592579
19Nitrogen metabolism_Homo sapiens_hsa009101.73713669
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66684180
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66074161
22Collecting duct acid secretion_Homo sapiens_hsa049661.61022097
23Long-term depression_Homo sapiens_hsa047301.60367477
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59645081
25Cocaine addiction_Homo sapiens_hsa050301.58364149
26Serotonergic synapse_Homo sapiens_hsa047261.57544325
27Vitamin B6 metabolism_Homo sapiens_hsa007501.56046902
28Oxytocin signaling pathway_Homo sapiens_hsa049211.55239861
29Calcium signaling pathway_Homo sapiens_hsa040201.54992056
30Renin secretion_Homo sapiens_hsa049241.54389555
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43981656
32GnRH signaling pathway_Homo sapiens_hsa049121.39388038
33cAMP signaling pathway_Homo sapiens_hsa040241.30421709
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26507185
35Gap junction_Homo sapiens_hsa045401.25237154
36Type II diabetes mellitus_Homo sapiens_hsa049301.15169627
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12949413
38Estrogen signaling pathway_Homo sapiens_hsa049151.08448119
39Vibrio cholerae infection_Homo sapiens_hsa051101.05006766
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01381644
41Cardiac muscle contraction_Homo sapiens_hsa042600.97681838
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97150355
43Glioma_Homo sapiens_hsa052140.95914010
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91995474
45Pancreatic secretion_Homo sapiens_hsa049720.91695339
46Melanogenesis_Homo sapiens_hsa049160.91473295
47ErbB signaling pathway_Homo sapiens_hsa040120.89831534
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.88683470
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88525260
50Axon guidance_Homo sapiens_hsa043600.87210228
51Thyroid hormone synthesis_Homo sapiens_hsa049180.86251401
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.83703140
53Dorso-ventral axis formation_Homo sapiens_hsa043200.80143458
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79474322
55Oocyte meiosis_Homo sapiens_hsa041140.77720115
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77186806
57Phototransduction_Homo sapiens_hsa047440.76226184
58Dilated cardiomyopathy_Homo sapiens_hsa054140.73104451
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72118502
60Bile secretion_Homo sapiens_hsa049760.70809915
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67880834
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65643806
63MAPK signaling pathway_Homo sapiens_hsa040100.64747635
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63233835
65Choline metabolism in cancer_Homo sapiens_hsa052310.61143618
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59629515
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.54466465
68Inositol phosphate metabolism_Homo sapiens_hsa005620.53503343
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51909937
70Endocytosis_Homo sapiens_hsa041440.51812549
71Type I diabetes mellitus_Homo sapiens_hsa049400.50785340
72Glucagon signaling pathway_Homo sapiens_hsa049220.50048733
73Ras signaling pathway_Homo sapiens_hsa040140.49679838
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49522046
75Arginine and proline metabolism_Homo sapiens_hsa003300.47736313
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47577352
77Prion diseases_Homo sapiens_hsa050200.45520482
78Rap1 signaling pathway_Homo sapiens_hsa040150.45338332
79Alcoholism_Homo sapiens_hsa050340.45075547
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.44891215
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44870816
82VEGF signaling pathway_Homo sapiens_hsa043700.43261194
83Circadian rhythm_Homo sapiens_hsa047100.40715336
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39706732
85Ovarian steroidogenesis_Homo sapiens_hsa049130.39066370
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38419370
87Histidine metabolism_Homo sapiens_hsa003400.38233893
88mTOR signaling pathway_Homo sapiens_hsa041500.37390478
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35085402
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.33458154
91Arginine biosynthesis_Homo sapiens_hsa002200.33377270
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32798499
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32112597
94Alzheimers disease_Homo sapiens_hsa050100.32091476
95Insulin signaling pathway_Homo sapiens_hsa049100.31652223
96Fatty acid biosynthesis_Homo sapiens_hsa000610.31137696
97Chemokine signaling pathway_Homo sapiens_hsa040620.30419370
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29319944
99Mineral absorption_Homo sapiens_hsa049780.29107235
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28191367
101Non-small cell lung cancer_Homo sapiens_hsa052230.27581430
102Renal cell carcinoma_Homo sapiens_hsa052110.27523557
103Wnt signaling pathway_Homo sapiens_hsa043100.25954138
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25676428
105Endometrial cancer_Homo sapiens_hsa052130.24689488
106HIF-1 signaling pathway_Homo sapiens_hsa040660.23546027
107beta-Alanine metabolism_Homo sapiens_hsa004100.23290641
108Rheumatoid arthritis_Homo sapiens_hsa053230.22315681
109AMPK signaling pathway_Homo sapiens_hsa041520.20543896
110Tight junction_Homo sapiens_hsa045300.19420505
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19152235
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16713097

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