FADS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)5.79112786
2behavioral response to nicotine (GO:0035095)5.33119761
3tooth mineralization (GO:0034505)5.12651999
4protein heterotrimerization (GO:0070208)4.80775638
5regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.29674547
6regulation of sequestering of triglyceride (GO:0010889)4.22419229
7positive regulation of fatty acid beta-oxidation (GO:0032000)4.09706789
8triglyceride catabolic process (GO:0019433)4.00108378
9valine metabolic process (GO:0006573)3.93731205
10regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.90909932
11white fat cell differentiation (GO:0050872)3.88423642
12positive regulation of fatty acid oxidation (GO:0046321)3.87088822
13regulation of glomerulus development (GO:0090192)3.82286421
14angiogenesis involved in wound healing (GO:0060055)3.80134767
15negative regulation of response to food (GO:0032096)3.76213856
16negative regulation of appetite (GO:0032099)3.76213856
17monoubiquitinated protein deubiquitination (GO:0035520)3.76064186
18collagen fibril organization (GO:0030199)3.75985776
19water-soluble vitamin biosynthetic process (GO:0042364)3.75105210
20response to gravity (GO:0009629)3.68559379
21fatty acid transmembrane transport (GO:1902001)3.67394558
22neutral lipid catabolic process (GO:0046461)3.65136870
23acylglycerol catabolic process (GO:0046464)3.65136870
24retina vasculature morphogenesis in camera-type eye (GO:0061299)3.63285221
25cellular response to vitamin (GO:0071295)3.62051722
26lipid particle organization (GO:0034389)3.61544486
27regulation of fatty acid beta-oxidation (GO:0031998)3.59913734
28brown fat cell differentiation (GO:0050873)3.57149616
29fatty acid beta-oxidation (GO:0006635)3.55964427
30negative regulation of nitric-oxide synthase activity (GO:0051001)3.50074891
31positive regulation of glomerulus development (GO:0090193)3.49734116
32pharyngeal system development (GO:0060037)3.48432093
33middle ear morphogenesis (GO:0042474)3.47939750
34kidney mesenchyme development (GO:0072074)3.47335034
35positive regulation of metanephros development (GO:0072216)3.46932513
36endothelial cell morphogenesis (GO:0001886)3.44738068
37biotin metabolic process (GO:0006768)3.40348404
38carnitine shuttle (GO:0006853)3.37530527
39apoptotic cell clearance (GO:0043277)3.35606777
40lymphangiogenesis (GO:0001946)3.34211207
41plasma membrane repair (GO:0001778)3.32833912
42basement membrane organization (GO:0071711)3.32374015
43regulation of fatty acid oxidation (GO:0046320)3.29940776
44regulation of cholesterol storage (GO:0010885)3.25645136
45negative regulation of fatty acid transport (GO:2000192)3.24182396
46chondrocyte proliferation (GO:0035988)3.23343706
47sulfation (GO:0051923)3.21981121
48cellular response to ATP (GO:0071318)3.21234622
49fatty acid oxidation (GO:0019395)3.19491240
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18444464
51positive regulation of cellular response to insulin stimulus (GO:1900078)3.18111731
52regulation of tight junction assembly (GO:2000810)3.17250817
53cell adhesion mediated by integrin (GO:0033627)3.16677037
54epithelial cell-cell adhesion (GO:0090136)3.16199432
55metanephric mesenchyme development (GO:0072075)3.16130353
56cell migration involved in heart development (GO:0060973)3.14261781
57lipid oxidation (GO:0034440)3.12667163
58lung morphogenesis (GO:0060425)3.12346512
59vascular endothelial growth factor signaling pathway (GO:0038084)3.10445374
60skin morphogenesis (GO:0043589)3.08156233
61positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.07758027
62epoxygenase P450 pathway (GO:0019373)3.06257028
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05030599
64renal filtration (GO:0097205)3.04908845
65stress fiber assembly (GO:0043149)3.04100738
66carnitine transport (GO:0015879)3.02901091
67amino-acid betaine transport (GO:0015838)3.02901091
68negative regulation of systemic arterial blood pressure (GO:0003085)3.02728298
69positive regulation of triglyceride biosynthetic process (GO:0010867)3.01273079
70cell proliferation in forebrain (GO:0021846)3.00333594
71fatty acid catabolic process (GO:0009062)2.97566340
72lysine metabolic process (GO:0006553)2.97557790
73lysine catabolic process (GO:0006554)2.97557790
74tricarboxylic acid metabolic process (GO:0072350)2.96089108
75triglyceride biosynthetic process (GO:0019432)2.94187624
76positive regulation of endothelial cell apoptotic process (GO:2000353)2.93558283
77gamma-aminobutyric acid transport (GO:0015812)2.93117623
78serotonin metabolic process (GO:0042428)2.92585337
79cell-substrate junction assembly (GO:0007044)2.91551216
80aorta morphogenesis (GO:0035909)2.91425873
81ovulation from ovarian follicle (GO:0001542)2.88459277
82base-excision repair, AP site formation (GO:0006285)2.87768080
83branched-chain amino acid metabolic process (GO:0009081)2.85242860
84glomerular filtration (GO:0003094)2.84954230
85carnitine transmembrane transport (GO:1902603)2.84850536
86positive regulation of endothelial cell differentiation (GO:0045603)2.84398543
87acylglycerol biosynthetic process (GO:0046463)2.83644675
88neutral lipid biosynthetic process (GO:0046460)2.83644675
89endodermal cell differentiation (GO:0035987)2.83537008
90quaternary ammonium group transport (GO:0015697)2.82773389
913-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.82378817
92purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.82378817
93primary amino compound metabolic process (GO:1901160)2.81817311
94positive regulation of fatty acid metabolic process (GO:0045923)2.78969334
952-oxoglutarate metabolic process (GO:0006103)2.77616907
96metanephric tubule development (GO:0072170)2.77283019
97metanephric nephron tubule development (GO:0072234)2.77283019
98negative regulation of smooth muscle cell migration (GO:0014912)2.77241826
99growth hormone receptor signaling pathway (GO:0060396)2.76457240
100alpha-linolenic acid metabolic process (GO:0036109)2.75975643
101negative regulation of membrane potential (GO:0045837)2.75904342
102oxaloacetate metabolic process (GO:0006107)2.74630691
103metanephric nephron epithelium development (GO:0072243)2.74274726
104acetyl-CoA metabolic process (GO:0006084)2.73971775
105negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.71661245
106regulation of endothelial cell differentiation (GO:0045601)2.70416630
107axon extension involved in axon guidance (GO:0048846)2.69622083
108neuron projection extension involved in neuron projection guidance (GO:1902284)2.69622083
109regulation of phospholipid biosynthetic process (GO:0071071)2.67877946
110outer ear morphogenesis (GO:0042473)2.67250437
111embryonic skeletal joint morphogenesis (GO:0060272)2.66350687
112positive regulation of glucose import (GO:0046326)2.65693068
113insulin-like growth factor receptor signaling pathway (GO:0048009)2.65684184
114protein K48-linked deubiquitination (GO:0071108)2.65237665
115NADH metabolic process (GO:0006734)2.64222599
116endocardial cushion development (GO:0003197)2.62905251
117negative regulation of DNA biosynthetic process (GO:2000279)2.62316308
118positive regulation of glycogen biosynthetic process (GO:0045725)2.61844669
119positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61623375
120multicellular organismal macromolecule metabolic process (GO:0044259)2.59922584
121collagen metabolic process (GO:0032963)2.59320265
122venous blood vessel morphogenesis (GO:0048845)2.58566702
123regulation of hippo signaling (GO:0035330)2.57969080
124regulation of gonadotropin secretion (GO:0032276)2.56516512
125protein localization to cell surface (GO:0034394)2.56245331
126multicellular organismal metabolic process (GO:0044236)2.56209317
127response to BMP (GO:0071772)2.55728482
128cellular response to BMP stimulus (GO:0071773)2.55728482
129negative regulation of response to extracellular stimulus (GO:0032105)2.55428764
130negative regulation of response to nutrient levels (GO:0032108)2.55428764
131glomerular basement membrane development (GO:0032836)2.54959396
132branched-chain amino acid catabolic process (GO:0009083)2.54582996
133regulation of cell proliferation involved in kidney development (GO:1901722)2.54557905
134regulation of triglyceride biosynthetic process (GO:0010866)2.54172405
135positive regulation of insulin receptor signaling pathway (GO:0046628)2.53935091
136surfactant homeostasis (GO:0043129)2.52310925
137negative regulation of hormone biosynthetic process (GO:0032353)2.51367301
138regulation of cardioblast proliferation (GO:0003264)2.51238936
139regulation of secondary heart field cardioblast proliferation (GO:0003266)2.51238936
140regulation of receptor binding (GO:1900120)2.49584827
141regulation of p38MAPK cascade (GO:1900744)2.49482496
142collagen catabolic process (GO:0030574)2.49454344
143triglyceride metabolic process (GO:0006641)2.49063346
144negative regulation of protein localization to cell surface (GO:2000009)2.49034109
145behavioral response to pain (GO:0048266)2.48358861
146positive regulation of p38MAPK cascade (GO:1900745)2.48104910
147adherens junction assembly (GO:0034333)2.48066490
148hemidesmosome assembly (GO:0031581)2.47803203
149negative regulation of blood pressure (GO:0045776)2.47545446
150protein polyglutamylation (GO:0018095)2.47481918
151metanephric epithelium development (GO:0072207)2.46813917
152sequestering of extracellular ligand from receptor (GO:0035581)2.46189445
153positive regulation of lipid catabolic process (GO:0050996)2.46180644
154negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.46122297
155negative regulation of protein autophosphorylation (GO:0031953)2.45984466
156cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.44372921
157iron ion import (GO:0097286)2.43439611
158negative regulation of cardiac muscle tissue development (GO:0055026)2.43343734
159negative regulation of platelet activation (GO:0010544)2.43231626
160wound healing, spreading of epidermal cells (GO:0035313)2.42972460
161negative regulation of cell size (GO:0045792)2.42764272
162virion attachment to host cell (GO:0019062)2.42449459
163adhesion of symbiont to host cell (GO:0044650)2.42449459
164endocytic recycling (GO:0032456)2.42418667
165fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.42157477
166regulation of female receptivity (GO:0045924)2.40368829
167thyroid gland development (GO:0030878)2.39898453
168tricarboxylic acid cycle (GO:0006099)2.39657629
169regulation of DNA biosynthetic process (GO:2000278)2.38283635
170dermatan sulfate metabolic process (GO:0030205)2.37924006
171mesonephros development (GO:0001823)2.37345838
172regulation of metanephros development (GO:0072215)2.34905928
173negative regulation of lipid storage (GO:0010888)2.34673133
174regulation of appetite (GO:0032098)2.33978931
175regulation of response to food (GO:0032095)2.33563921
176ovulation cycle (GO:0042698)2.33411358
177transmission of nerve impulse (GO:0019226)2.31583736
178regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.29355963
179regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.29355963
180pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.28701344
181negative regulation of hormone metabolic process (GO:0032351)2.27390988
182positive regulation of action potential (GO:0045760)2.27316564
183negative regulation of axon extension involved in axon guidance (GO:0048843)2.26643200
184negative regulation of cardiac muscle tissue growth (GO:0055022)2.23798619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.74889958
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.64520179
3EZH2_22144423_ChIP-Seq_EOC_Human4.34511888
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.09009675
5CLOCK_20551151_ChIP-Seq_293T_Human3.86032589
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.83731702
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.58634900
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.10037893
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65325551
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.58303219
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.48165902
12SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41059446
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.37062895
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.35779682
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34985116
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.26933346
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21989871
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.18762026
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.05683894
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.05161574
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04460187
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.03066662
23* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.98622263
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97531748
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.97338053
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96979297
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95690637
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.95024760
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89001769
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.88990941
31CJUN_26792858_Chip-Seq_BT549_Human1.83471964
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77101213
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76593981
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73349299
35CTCF_27219007_Chip-Seq_Bcells_Human1.68965679
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.68631912
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65633863
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65478338
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65412346
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.65363606
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64901053
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.63294335
43ZNF263_19887448_ChIP-Seq_K562_Human1.60500865
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58412650
45* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.58179521
46SMC3_22415368_ChIP-Seq_MEFs_Mouse1.57648246
47* TBX20_22328084_ChIP-Seq_HEART_Mouse1.56472800
48* TBX20_22080862_ChIP-Seq_HEART_Mouse1.56472800
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50569202
50TP53_23651856_ChIP-Seq_MEFs_Mouse1.50219072
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.49673811
52* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48458648
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.47242383
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46979759
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46887580
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46683866
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43966283
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43966283
59* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43583409
60DROSHA_22980978_ChIP-Seq_HELA_Human1.42234723
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.40974921
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39333750
63* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36891276
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36537322
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.34925837
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.33965671
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33377396
68* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.31914512
69SOX2_20726797_ChIP-Seq_SW620_Human1.30642207
70* P68_20966046_ChIP-Seq_HELA_Human1.29338702
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.29318887
72ATF3_27146783_Chip-Seq_COLON_Human1.28059734
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28010510
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26279541
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25681372
76* RACK7_27058665_Chip-Seq_MCF-7_Human1.24864255
77CTCF_20526341_ChIP-Seq_ESCs_Human1.23528916
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23108226
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23079991
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22698340
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21902039
82* LXR_22292898_ChIP-Seq_THP-1_Human1.20103123
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19607728
84BCL6_27268052_Chip-Seq_Bcells_Human1.18906700
85* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.18504486
86* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18372506
87* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18372506
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18249855
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18249855
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17132315
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16426692
92REST_21632747_ChIP-Seq_MESCs_Mouse1.15651864
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15575425
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15334466
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14962990
96BRD4_25478319_ChIP-Seq_HGPS_Human1.13664316
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12878985
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12150080
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11016614
100SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09218577
101GBX2_23144817_ChIP-Seq_PC3_Human1.09026266
102E2F1_20622854_ChIP-Seq_HELA_Human1.08675213
103SA1_22415368_ChIP-Seq_MEFs_Mouse1.08599184
104ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08582775
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07234423
106TP53_16413492_ChIP-PET_HCT116_Human1.06415312
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05555160
108KDM2B_26808549_Chip-Seq_K562_Human1.05444505
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.05394730
110* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05070040
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05031734
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03929289
113ERA_21632823_ChIP-Seq_H3396_Human1.03662672
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03652400
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03393758
116SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00295214
117TP53_18474530_ChIP-ChIP_U2OS_Human1.00132132
118* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99723556
119MYC_27129775_Chip-Seq_CORNEA_Mouse0.99595981
120* TP63_22573176_ChIP-Seq_HFKS_Human0.99175147
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98406120
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98355741
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.96676788
124* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95803553
125RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95216989
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94812395
127IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94621641
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.94567174
129KLF4_19829295_ChIP-Seq_ESCs_Human0.94524127
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94422189
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93972253
132TAF2_19829295_ChIP-Seq_ESCs_Human0.93725782
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93704185
134UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93408321
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.92748799
136NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92546090
137STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92109044
138PHF8_20622854_ChIP-Seq_HELA_Human0.92024773
139AHR_22903824_ChIP-Seq_MCF-7_Human0.91998054
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91453468
141CTCF_26484167_Chip-Seq_Bcells_Mouse0.91356341
142GATA1_22025678_ChIP-Seq_K562_Human0.90995476
143RXR_22108803_ChIP-Seq_LS180_Human0.90626756
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.90452556
145* SMC4_20622854_ChIP-Seq_HELA_Human0.90441646
146* SA1_27219007_Chip-Seq_ERYTHROID_Human0.90323386
147EED_16625203_ChIP-ChIP_MESCs_Mouse0.89943205
148TP53_20018659_ChIP-ChIP_R1E_Mouse0.89021861
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88840751
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.88568493
151TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87500732
152RAC3_21632823_ChIP-Seq_H3396_Human0.87089324
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86587555
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85769753
155TP53_22127205_ChIP-Seq_IMR90_Human0.85688743
156* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85344029
157ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85180790
158SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85010140
159SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84941085
160UBF1/2_26484160_Chip-Seq_HMECs_Human0.84676288
161TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82720802
162* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81841919
163ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81766997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.30786172
2MP0003646_muscle_fatigue5.35973102
3MP0005670_abnormal_white_adipose4.24600413
4MP0005275_abnormal_skin_tensile4.08944599
5MP0003705_abnormal_hypodermis_morpholog3.69424700
6MP0005666_abnormal_adipose_tissue3.13242268
7MP0004130_abnormal_muscle_cell2.91730715
8MP0001958_emphysema2.87732656
9MP0004272_abnormal_basement_membrane2.77957067
10MP0002837_dystrophic_cardiac_calcinosis2.77732194
11MP0000013_abnormal_adipose_tissue2.68139981
12MP0004185_abnormal_adipocyte_glucose2.60494056
13MP0005375_adipose_tissue_phenotype2.56247102
14MP0003279_aneurysm2.51831740
15MP0004145_abnormal_muscle_electrophysio2.36641062
16MP0000751_myopathy2.22354673
17MP0005503_abnormal_tendon_morphology2.12185365
18MP0000003_abnormal_adipose_tissue2.09105649
19MP0003566_abnormal_cell_adhesion2.09029152
20MP0003011_delayed_dark_adaptation2.03722620
21MP0000049_abnormal_middle_ear2.02348566
22MP0001968_abnormal_touch/_nociception1.88634801
23MP0005623_abnormal_meninges_morphology1.75389029
24MP0003879_abnormal_hair_cell1.75203267
25MP0000678_abnormal_parathyroid_gland1.73831394
26MP0002736_abnormal_nociception_after1.68177210
27MP0000750_abnormal_muscle_regeneration1.65004683
28MP0009250_abnormal_appendicular_skeleto1.64134412
29MP0002971_abnormal_brown_adipose1.63969086
30MP0009384_cardiac_valve_regurgitation1.59209305
31MP0003191_abnormal_cellular_cholesterol1.51821496
32MP0010329_abnormal_lipoprotein_level1.49182684
33MP0001348_abnormal_lacrimal_gland1.48329816
34MP0002295_abnormal_pulmonary_circulatio1.48149544
35MP0005360_urolithiasis1.46918371
36MP0009115_abnormal_fat_cell1.46509666
37MP0010368_abnormal_lymphatic_system1.43564339
38MP0002060_abnormal_skin_morphology1.42996645
39MP0002876_abnormal_thyroid_physiology1.40853048
40MP0004084_abnormal_cardiac_muscle1.38084935
41MP0002139_abnormal_hepatobiliary_system1.37956183
42MP0004087_abnormal_muscle_fiber1.37794496
43MP0002933_joint_inflammation1.37553291
44MP0000749_muscle_degeneration1.37520797
45MP0009780_abnormal_chondrocyte_physiolo1.35648247
46MP0003091_abnormal_cell_migration1.34239130
47MP0006138_congestive_heart_failure1.34186630
48MP0006292_abnormal_olfactory_placode1.32104440
49MP0000537_abnormal_urethra_morphology1.31640324
50MP0008775_abnormal_heart_ventricle1.31025280
51MP0002160_abnormal_reproductive_system1.30739003
52MP0002108_abnormal_muscle_morphology1.24713752
53MP0000230_abnormal_systemic_arterial1.24201033
54MP0003959_abnormal_lean_body1.22414260
55MP0002249_abnormal_larynx_morphology1.20956031
56MP0005646_abnormal_pituitary_gland1.19961981
57MP0003942_abnormal_urinary_system1.19867003
58MP0005334_abnormal_fat_pad1.18923039
59MP0002168_other_aberrant_phenotype1.18682948
60MP0009053_abnormal_anal_canal1.18008051
61MP0006054_spinal_hemorrhage1.17004601
62MP0003045_fibrosis1.16836649
63MP0004133_heterotaxia1.15816437
64MP0005330_cardiomyopathy1.15675889
65MP0004215_abnormal_myocardial_fiber1.15548221
66MP0000759_abnormal_skeletal_muscle1.14903250
67MP0005620_abnormal_muscle_contractility1.14289765
68MP0000733_abnormal_muscle_development1.13340269
69MP0001879_abnormal_lymphatic_vessel1.11865671
70MP0002118_abnormal_lipid_homeostasis1.10788311
71MP0002970_abnormal_white_adipose1.10018725
72MP0002735_abnormal_chemical_nociception1.09384653
73MP0002733_abnormal_thermal_nociception1.07535655
74MP0002972_abnormal_cardiac_muscle1.06227399
75MP0005023_abnormal_wound_healing1.06090338
76MP0001853_heart_inflammation1.05396333
77MP0001905_abnormal_dopamine_level1.05121249
78MP0002896_abnormal_bone_mineralization1.04621620
79MP0001661_extended_life_span1.03309402
80MP0005332_abnormal_amino_acid1.02711286
81MP0003300_gastrointestinal_ulcer1.02274500
82MP0005385_cardiovascular_system_phenoty1.01789794
83MP0001544_abnormal_cardiovascular_syste1.01789794
84MP0001542_abnormal_bone_strength1.00425213
85MP0002932_abnormal_joint_morphology0.99777070
86MP0003137_abnormal_impulse_conducting0.99347782
87MP0004885_abnormal_endolymph0.98878620
88MP0003828_pulmonary_edema0.98730209
89MP0003283_abnormal_digestive_organ0.98531882
90MP0009643_abnormal_urine_homeostasis0.98270904
91MP0002272_abnormal_nervous_system0.97761502
92MP0001756_abnormal_urination0.95589520
93MP0010352_gastrointestinal_tract_polyps0.95306385
94MP0001970_abnormal_pain_threshold0.94995269
95MP0000747_muscle_weakness0.94636891
96MP0005164_abnormal_response_to0.93945961
97MP0000534_abnormal_ureter_morphology0.93262190
98MP0002877_abnormal_melanocyte_morpholog0.93146429
99MP0005508_abnormal_skeleton_morphology0.93016526
100MP0000538_abnormal_urinary_bladder0.92397957
101MP0005595_abnormal_vascular_smooth0.92158694
102MP0003252_abnormal_bile_duct0.91973196
103MP0004134_abnormal_chest_morphology0.91270115
104MP0002796_impaired_skin_barrier0.90731000
105MP0000681_abnormal_thyroid_gland0.89342637
106MP0010630_abnormal_cardiac_muscle0.85129781
107MP0005551_abnormal_eye_electrophysiolog0.84553180
108MP0005389_reproductive_system_phenotype0.84297805
109MP0004036_abnormal_muscle_relaxation0.83965597
110MP0001299_abnormal_eye_distance/0.82633432
111MP0000343_altered_response_to0.81791807
112MP0010030_abnormal_orbit_morphology0.81549920
113MP0000767_abnormal_smooth_muscle0.80977931
114MP0005388_respiratory_system_phenotype0.80802671
115MP0002133_abnormal_respiratory_system0.80802671
116MP0006276_abnormal_autonomic_nervous0.80569262
117MP0002734_abnormal_mechanical_nocicepti0.80171274
118MP0004085_abnormal_heartbeat0.78799354
119MP0002909_abnormal_adrenal_gland0.78684995
120MP0001177_atelectasis0.78198747
121MP0008004_abnormal_stomach_pH0.78008721
122MP0001440_abnormal_grooming_behavior0.77978210
123MP0000026_abnormal_inner_ear0.77386288
124MP0001243_abnormal_dermal_layer0.77152214
125MP0002653_abnormal_ependyma_morphology0.76963687
126MP0003724_increased_susceptibility_to0.75542309
127MP0000163_abnormal_cartilage_morphology0.75424495
128MP0005365_abnormal_bile_salt0.75365915
129MP0002269_muscular_atrophy0.75117673
130MP0002106_abnormal_muscle_physiology0.74530052
131MP0003950_abnormal_plasma_membrane0.74002325
132MP0010386_abnormal_urinary_bladder0.73210977
133MP0004233_abnormal_muscle_weight0.73202770
134MP0002128_abnormal_blood_circulation0.72635298
135MP0004484_altered_response_of0.71390847
136MP0003186_abnormal_redox_activity0.70363568
137MP0008961_abnormal_basal_metabolism0.69986362
138MP0001727_abnormal_embryo_implantation0.69805554
139MP0001502_abnormal_circadian_rhythm0.69473607
140MP0005535_abnormal_body_temperature0.69152128
141MP0005369_muscle_phenotype0.69105333
142MP0009745_abnormal_behavioral_response0.69063822
143MP0005390_skeleton_phenotype0.68792686
144MP0005448_abnormal_energy_balance0.67627602
145MP0000467_abnormal_esophagus_morphology0.67326378
146MP0005165_increased_susceptibility_to0.67074427
147MP0001963_abnormal_hearing_physiology0.66976734
148MP0000609_abnormal_liver_physiology0.66255144
149MP0005257_abnormal_intraocular_pressure0.65558177

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)6.34153717
2Premature rupture of membranes (HP:0001788)6.12690156
3Protrusio acetabuli (HP:0003179)5.72696806
4Increased connective tissue (HP:0009025)4.14858069
5Ankle contracture (HP:0006466)3.88476593
6Cerebral aneurysm (HP:0004944)3.67831077
7Type 1 muscle fiber predominance (HP:0003803)3.64100827
8Aortic dissection (HP:0002647)3.63838888
9Broad metatarsal (HP:0001783)3.52424816
10Shallow orbits (HP:0000586)3.49233726
11Acanthosis nigricans (HP:0000956)3.35819244
12Muscle fiber splitting (HP:0003555)3.34311144
13Atrophic scars (HP:0001075)3.29722645
14Spinal rigidity (HP:0003306)3.26916858
15Meningioma (HP:0002858)3.23331305
16Peritonitis (HP:0002586)3.21930477
17Increased variability in muscle fiber diameter (HP:0003557)3.14226302
18Short femoral neck (HP:0100864)3.13304960
19Mesomelia (HP:0003027)3.11962481
20Right ventricular cardiomyopathy (HP:0011663)3.05551568
21Joint stiffness (HP:0001387)3.05486727
22Aortic aneurysm (HP:0004942)3.04890702
23Oligomenorrhea (HP:0000876)3.02124284
24Radial bowing (HP:0002986)3.00518810
25Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.00339363
26Fragile skin (HP:0001030)2.99018022
27Soft skin (HP:0000977)2.94425832
28Morphological abnormality of the middle ear (HP:0008609)2.90523076
29Dilatation of the ascending aorta (HP:0005111)2.85210413
30Mildly elevated creatine phosphokinase (HP:0008180)2.83324388
31Abnormality of skeletal muscle fiber size (HP:0012084)2.82715175
32Difficulty running (HP:0009046)2.76974423
33Keratoconus (HP:0000563)2.73861094
34Increased corneal curvature (HP:0100692)2.73861094
35Mitral valve prolapse (HP:0001634)2.70747423
36Myotonia (HP:0002486)2.66098112
37Cervical subluxation (HP:0003308)2.65311068
38Decreased subcutaneous fat (HP:0001002)2.64969789
39Methylmalonic aciduria (HP:0012120)2.64884468
40Genetic anticipation (HP:0003743)2.62272760
41Difficulty climbing stairs (HP:0003551)2.60090668
42Neonatal short-limb short stature (HP:0008921)2.58878597
43Ulnar deviation of the wrist (HP:0003049)2.58459766
44Abnormality of the proximal phalanges of the hand (HP:0009834)2.57290865
45Aplasia/hypoplasia of the femur (HP:0005613)2.53744876
46Bladder diverticulum (HP:0000015)2.53314740
47Hyporeflexia of lower limbs (HP:0002600)2.52913402
48Follicular hyperkeratosis (HP:0007502)2.52274694
49Mesangial abnormality (HP:0001966)2.52227674
50Hyperglycinuria (HP:0003108)2.48770848
51Methylmalonic acidemia (HP:0002912)2.46932567
52Hypertriglyceridemia (HP:0002155)2.46647516
53Abnormality of the middle phalanges of the toes (HP:0010183)2.46534245
54Blue sclerae (HP:0000592)2.46120623
55Bowed forearm bones (HP:0003956)2.45291020
56Bowing of the arm (HP:0006488)2.45291020
57Limited hip movement (HP:0008800)2.44770652
58Hyperthyroidism (HP:0000836)2.44688765
59Abnormality of proline metabolism (HP:0010907)2.38552480
60Hydroxyprolinuria (HP:0003080)2.38552480
61Scapular winging (HP:0003691)2.38143313
62Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.37962772
63Bradycardia (HP:0001662)2.37454167
64Distal upper limb amyotrophy (HP:0007149)2.35457408
65Upper limb amyotrophy (HP:0009129)2.35457408
66Abnormality of binocular vision (HP:0011514)2.34888919
67Diplopia (HP:0000651)2.34888919
68Slender build (HP:0001533)2.32431460
69Genu recurvatum (HP:0002816)2.32054761
70Symphalangism affecting the phalanges of the hand (HP:0009773)2.32019021
71Congenital, generalized hypertrichosis (HP:0004540)2.30813122
72Infantile muscular hypotonia (HP:0008947)2.30551222
73Abnormality of the phalanges of the 2nd finger (HP:0009541)2.29300527
74Abnormality of subcutaneous fat tissue (HP:0001001)2.28926106
75Aneurysm (HP:0002617)2.27084286
76Abnormality of dentin (HP:0010299)2.25919287
77Short hallux (HP:0010109)2.24586453
78Lymphangioma (HP:0100764)2.21145933
79Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.20786509
80Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.20301786
81Coronal craniosynostosis (HP:0004440)2.19609916
82Porencephaly (HP:0002132)2.18366946
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17293909
84Ovoid vertebral bodies (HP:0003300)2.17264862
85Wormian bones (HP:0002645)2.16581732
86Irregular vertebral endplates (HP:0003301)2.16544158
87Thin bony cortex (HP:0002753)2.15441195
88Hemiplegia (HP:0002301)2.15132349
89Visual hallucinations (HP:0002367)2.13523956
90Round ear (HP:0100830)2.11732678
91Hyperextensible skin (HP:0000974)2.09979384
92Abnormality of glycine metabolism (HP:0010895)2.09866594
93Abnormality of serine family amino acid metabolism (HP:0010894)2.09866594
94Lipoatrophy (HP:0100578)2.09699607
95Hypoplasia of the uterus (HP:0000013)2.08623717
96Agitation (HP:0000713)2.08108944
97Abnormal cartilage morphology (HP:0002763)2.06786613
98Congenital stationary night blindness (HP:0007642)2.05800119
99Venous abnormality (HP:0002624)2.05237193
100Aortic regurgitation (HP:0001659)2.04765788
101Ketoacidosis (HP:0001993)2.04308246
102Adactyly (HP:0009776)2.04207764
103Aplasia/Hypoplasia of the hallux (HP:0008362)2.03078948
104Short 4th metacarpal (HP:0010044)2.02250682
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02250682
106Ectopia lentis (HP:0001083)2.01183344
107Myocardial infarction (HP:0001658)2.01103244
108Fused cervical vertebrae (HP:0002949)1.99840820
109Elbow flexion contracture (HP:0002987)1.99666198
110Pendular nystagmus (HP:0012043)1.99295286
111Long toe (HP:0010511)1.99250864
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.97661680
113Osteolytic defects of the hand bones (HP:0009699)1.97661680
114Camptodactyly of toe (HP:0001836)1.96521281
115Buphthalmos (HP:0000557)1.95882396
116Vertebral compression fractures (HP:0002953)1.95806296
117Wrist flexion contracture (HP:0001239)1.94687432
118Knee flexion contracture (HP:0006380)1.94228628
119Abnormality of the phalanges of the 5th finger (HP:0004213)1.94079245
120Abnormality of the vertebral endplates (HP:0005106)1.93441226
121Type II lissencephaly (HP:0007260)1.91641754
122Abnormal delivery (HP:0001787)1.91459322
123Aplasia of the musculature (HP:0100854)1.89122013
124Gout (HP:0001997)1.88999223
125Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88482183
126Overgrowth (HP:0001548)1.88393151
127Hyperglycinemia (HP:0002154)1.87378169
128Short nail (HP:0001799)1.87280589
129Synostosis of carpal bones (HP:0005048)1.86539521
130Hematochezia (HP:0002573)1.85094858
131Hand muscle atrophy (HP:0009130)1.84355087
132Biconcave vertebral bodies (HP:0004586)1.83382278
133Severe visual impairment (HP:0001141)1.82686861
134Bone cyst (HP:0012062)1.82565192
135Sudden death (HP:0001699)1.81168457
136Asymmetric septal hypertrophy (HP:0001670)1.80974354
137Confusion (HP:0001289)1.80631079
138Abnormality of the calf musculature (HP:0001430)1.79939976
139Abnormality of the neuromuscular junction (HP:0003398)1.79875254
140Fatigable weakness (HP:0003473)1.79875254
141Benign neoplasm of the central nervous system (HP:0100835)1.79798625
142Abnormality of the costochondral junction (HP:0000919)1.79385281
143Chondrocalcinosis (HP:0000934)1.78361223
144Chorioretinal atrophy (HP:0000533)1.78274609
145Vascular tortuosity (HP:0004948)1.78261018
146Xanthomatosis (HP:0000991)1.77941096
147Absent phalangeal crease (HP:0006109)1.77481839
148Hypoalphalipoproteinemia (HP:0003233)1.77311412
149Bowel diverticulosis (HP:0005222)1.76076253
150Waddling gait (HP:0002515)1.75832467
151Increased purine levels (HP:0004368)1.75403459
152Hyperuricemia (HP:0002149)1.75403459
153Myoglobinuria (HP:0002913)1.74695292
154Distal lower limb amyotrophy (HP:0008944)1.74649739
155Hip contracture (HP:0003273)1.74098545
156Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73702080
157Short 1st metacarpal (HP:0010034)1.73702080
158Wide anterior fontanel (HP:0000260)1.73544845
159Abnormality of the 4th metacarpal (HP:0010012)1.73005608
160Abnormality of the acetabulum (HP:0003170)1.72820427
161Achilles tendon contracture (HP:0001771)1.72126405
162Venous insufficiency (HP:0005293)1.71734028
163Ketosis (HP:0001946)1.71711868
164Turricephaly (HP:0000262)1.70510779
165Abnormality of the Achilles tendon (HP:0005109)1.70222881
166Generalized amyotrophy (HP:0003700)1.69479792
167Generalized muscle weakness (HP:0003324)1.69369864
168Bronchomalacia (HP:0002780)1.68276569
169Abnormality of fatty-acid metabolism (HP:0004359)1.67719447
170Enlarged penis (HP:0000040)1.66210323
171Tibial bowing (HP:0002982)1.65005599
172Osteopenia (HP:0000938)1.64298877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.82975701
2TTN3.42131389
3MAP3K133.27461992
4MUSK2.96570012
5SIK12.84770004
6CAMK1D2.81160173
7PDGFRA2.74684998
8PKN22.74397656
9DDR22.55076258
10ERN12.44641912
11GRK12.43501499
12RIPK12.37047269
13ADRBK22.36790025
14EPHB22.10397133
15LMTK22.04980854
16CAMK1G2.00742611
17LATS21.97309710
18BCKDK1.83365833
19PDK41.81098107
20PDK31.81098107
21TLK11.76808501
22MYLK1.76450796
23FER1.75268496
24MST1R1.74482578
25PINK11.70071164
26WNK41.48150472
27LATS11.41828663
28PTK2B1.41399469
29MAP2K11.41227372
30TAOK31.40435568
31ADRBK11.39299210
32MOS1.36512027
33FLT31.35437830
34TGFBR21.31154315
35PAK21.30401205
36TIE11.30214257
37LRRK21.28876143
38ILK1.27653652
39PTK21.23229867
40GRK51.22024543
41FRK1.20921325
42MAP3K111.18430689
43PTK61.15203576
44BMX1.13957895
45PIK3CA1.11762873
46PAK41.11139029
47KDR1.11114198
48DMPK1.11037142
49PAK31.07544299
50MAP2K21.07315286
51PDK21.04522989
52MARK11.03032062
53MAPK41.00165277
54PDGFRB0.99396456
55MET0.97228258
56GRK70.96138211
57MAP3K90.95779160
58PRKD30.93823510
59IKBKB0.93519828
60RET0.93502270
61ROCK10.92471811
62TXK0.91074625
63PHKG20.91000656
64PHKG10.91000656
65FGFR20.90987137
66TRPM70.89054734
67PRKAA20.89021650
68NEK90.88808682
69CAMK10.88256540
70CDK60.87286845
71MAP2K60.86044457
72NTRK30.84267377
73STK38L0.83936269
74ABL20.82242590
75KIT0.80580258
76EPHA20.78908620
77NTRK10.78736669
78PRKCH0.77190473
79RPS6KA60.76837878
80MTOR0.75898059
81DAPK30.75666125
82MAPK150.73308213
83PKN10.71667075
84PRKD10.70703470
85STK380.70533752
86ARAF0.69011838
87FGFR40.68872157
88PRKG20.67245552
89PIK3CG0.66975914
90FGFR30.65879843
91EEF2K0.64155288
92PDPK10.64053171
93PAK60.64031022
94EPHB10.62192375
95FGFR10.60592328
96PRKD20.58467649
97ROCK20.56305746
98MAP3K30.55717994
99RPS6KL10.55507006
100RPS6KC10.55507006
101CAMK2B0.55415197
102CDK90.53850693
103JAK10.53571300
104MAP2K30.53066271
105LIMK10.52457993
106MAP3K70.52424036
107CAMKK10.51895484
108MAPK130.51753623
109CAMKK20.51378884
110MAPKAPK50.49806120
111CAMK2G0.49296781
112GSK3A0.49227922
113NTRK20.48938951
114KSR20.48816538
115MAP4K20.48766497
116PRKCG0.48489644
117INSR0.48089541
118TESK10.47188483
119PRKAA10.46382427
120WNK10.45660811
121PRKCE0.45188403
122OXSR10.45181521
123MAPK120.45129301
124ERBB20.45089305
125WNK30.45069140
126JAK30.43811751
127PRKACA0.43417389
128MAPK70.43416715
129MAP3K60.42552156
130GRK60.41952229
131AURKA0.41507819
132SRC0.41207312
133NEK10.39249667
134PRKCA0.38651395
135PRKCZ0.38650957
136MAPKAPK30.38615756
137MAP3K20.38231276
138CAMK2A0.37751394
139PIM20.36986395
140STK110.35793651
141STK30.34603417
142TAOK10.34072793
143RPS6KA20.33533420
144DAPK20.33238961
145IGF1R0.32619620
146CDC42BPA0.31764070
147INSRR0.31590388
148RPS6KA40.31549384

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.17626858
2PPAR signaling pathway_Homo sapiens_hsa033203.05233694
3Propanoate metabolism_Homo sapiens_hsa006402.89660467
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.87748733
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.71242585
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56106063
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.50476213
8Fatty acid degradation_Homo sapiens_hsa000712.44841730
9Fatty acid metabolism_Homo sapiens_hsa012122.43986748
10ECM-receptor interaction_Homo sapiens_hsa045122.40353103
11Fatty acid biosynthesis_Homo sapiens_hsa000612.35714659
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.98406584
13Phototransduction_Homo sapiens_hsa047441.93719270
14Nicotine addiction_Homo sapiens_hsa050331.92507086
15Morphine addiction_Homo sapiens_hsa050321.87610608
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.81765030
17Pyruvate metabolism_Homo sapiens_hsa006201.80995178
18Focal adhesion_Homo sapiens_hsa045101.80088374
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79004832
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75348046
21Glycerolipid metabolism_Homo sapiens_hsa005611.72980718
22Butanoate metabolism_Homo sapiens_hsa006501.63714552
23Adipocytokine signaling pathway_Homo sapiens_hsa049201.60212390
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58004295
25Protein digestion and absorption_Homo sapiens_hsa049741.56891080
26Carbon metabolism_Homo sapiens_hsa012001.49232263
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45242840
28Dilated cardiomyopathy_Homo sapiens_hsa054141.45166147
29AMPK signaling pathway_Homo sapiens_hsa041521.40568447
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39782460
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34240728
32Nitrogen metabolism_Homo sapiens_hsa009101.29980243
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28058209
34beta-Alanine metabolism_Homo sapiens_hsa004101.27185941
35Type II diabetes mellitus_Homo sapiens_hsa049301.25170365
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20355803
37Peroxisome_Homo sapiens_hsa041461.18911996
38Tryptophan metabolism_Homo sapiens_hsa003801.18719975
39Calcium signaling pathway_Homo sapiens_hsa040201.15763920
40Ovarian steroidogenesis_Homo sapiens_hsa049131.14610682
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13788401
42GABAergic synapse_Homo sapiens_hsa047271.13778993
43Proteoglycans in cancer_Homo sapiens_hsa052051.12142804
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12132027
45Olfactory transduction_Homo sapiens_hsa047401.11954573
46Taste transduction_Homo sapiens_hsa047421.10312569
47Bladder cancer_Homo sapiens_hsa052191.08521221
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08282254
49Glutamatergic synapse_Homo sapiens_hsa047241.06922524
50Linoleic acid metabolism_Homo sapiens_hsa005911.05314130
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05179415
52Amoebiasis_Homo sapiens_hsa051461.03300705
53Insulin secretion_Homo sapiens_hsa049111.01914200
54Circadian entrainment_Homo sapiens_hsa047131.01404288
55Basal cell carcinoma_Homo sapiens_hsa052171.01033880
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00062828
57Insulin resistance_Homo sapiens_hsa049310.99806731
58Insulin signaling pathway_Homo sapiens_hsa049100.99624860
59Caffeine metabolism_Homo sapiens_hsa002320.96580309
60Retinol metabolism_Homo sapiens_hsa008300.95005198
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94057921
62cAMP signaling pathway_Homo sapiens_hsa040240.93680946
63Fat digestion and absorption_Homo sapiens_hsa049750.92812204
64Adherens junction_Homo sapiens_hsa045200.88580623
65Phenylalanine metabolism_Homo sapiens_hsa003600.88092387
66Bile secretion_Homo sapiens_hsa049760.87061718
67Serotonergic synapse_Homo sapiens_hsa047260.85095019
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84557116
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83559468
70Cocaine addiction_Homo sapiens_hsa050300.83152513
71Axon guidance_Homo sapiens_hsa043600.83106883
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82755249
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82218382
74MAPK signaling pathway_Homo sapiens_hsa040100.81595133
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80188246
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79385055
77ABC transporters_Homo sapiens_hsa020100.78853582
78Ras signaling pathway_Homo sapiens_hsa040140.78087660
79Small cell lung cancer_Homo sapiens_hsa052220.76481981
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.74948819
81Cholinergic synapse_Homo sapiens_hsa047250.74615560
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74117281
83Arginine biosynthesis_Homo sapiens_hsa002200.73305121
84Tight junction_Homo sapiens_hsa045300.73109782
85Synaptic vesicle cycle_Homo sapiens_hsa047210.72842469
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72363814
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71815496
88Glucagon signaling pathway_Homo sapiens_hsa049220.70447854
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.70010978
90Starch and sucrose metabolism_Homo sapiens_hsa005000.69265893
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69109825
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67813329
93Oxidative phosphorylation_Homo sapiens_hsa001900.66811062
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66120411
95Glioma_Homo sapiens_hsa052140.65446517
96Melanoma_Homo sapiens_hsa052180.65111744
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64815945
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.64791068
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64523287
100Renin-angiotensin system_Homo sapiens_hsa046140.64490880
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63496769
102Salivary secretion_Homo sapiens_hsa049700.63353201
103Ribosome_Homo sapiens_hsa030100.63262519
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63245374
105Hedgehog signaling pathway_Homo sapiens_hsa043400.59953994
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59663852
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59546429
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58325844
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.58222424
110Renin secretion_Homo sapiens_hsa049240.57348344
111Sulfur metabolism_Homo sapiens_hsa009200.57120424
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56934519
113Tyrosine metabolism_Homo sapiens_hsa003500.55257862
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55072066
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.55012472
116Lysine degradation_Homo sapiens_hsa003100.54363203
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54236269
118Viral myocarditis_Homo sapiens_hsa054160.53967433
119Oxytocin signaling pathway_Homo sapiens_hsa049210.52266228
120Complement and coagulation cascades_Homo sapiens_hsa046100.52198253
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51962193
122Chronic myeloid leukemia_Homo sapiens_hsa052200.51133811
123HIF-1 signaling pathway_Homo sapiens_hsa040660.50452557
124Biosynthesis of amino acids_Homo sapiens_hsa012300.49910034
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48907302
126Platelet activation_Homo sapiens_hsa046110.48389109
127Dopaminergic synapse_Homo sapiens_hsa047280.48375886
128Hippo signaling pathway_Homo sapiens_hsa043900.47472496
129Thyroid hormone synthesis_Homo sapiens_hsa049180.46886497
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46232568
131Alzheimers disease_Homo sapiens_hsa050100.45334055
132Gastric acid secretion_Homo sapiens_hsa049710.45269077
133Glutathione metabolism_Homo sapiens_hsa004800.44373776
134Sulfur relay system_Homo sapiens_hsa041220.44292595
135Rap1 signaling pathway_Homo sapiens_hsa040150.44128105
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.43416337
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43117074
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42645631
139TGF-beta signaling pathway_Homo sapiens_hsa043500.42324399
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41952752
141Chemical carcinogenesis_Homo sapiens_hsa052040.41905922
142Arachidonic acid metabolism_Homo sapiens_hsa005900.41439083
143Pathways in cancer_Homo sapiens_hsa052000.40977695
144Dorso-ventral axis formation_Homo sapiens_hsa043200.39366932
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38942336
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38780705
147Malaria_Homo sapiens_hsa051440.37904712
148Gap junction_Homo sapiens_hsa045400.36096426
149Cardiac muscle contraction_Homo sapiens_hsa042600.35907724
150mTOR signaling pathway_Homo sapiens_hsa041500.35765178
151VEGF signaling pathway_Homo sapiens_hsa043700.34756727
152Endometrial cancer_Homo sapiens_hsa052130.34677485
153Fatty acid elongation_Homo sapiens_hsa000620.34221882
154Pancreatic cancer_Homo sapiens_hsa052120.33140584
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.31096233
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.30898556

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