FABP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.68616173
2spermatid development (GO:0007286)9.56475941
3piRNA metabolic process (GO:0034587)9.45155423
4reproduction (GO:0000003)9.39042985
5motile cilium assembly (GO:0044458)9.21762912
6male meiosis (GO:0007140)8.76245627
7synaptonemal complex organization (GO:0070193)8.39251313
8synaptonemal complex assembly (GO:0007130)8.16386599
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.13508933
10cilium movement (GO:0003341)8.03870369
11regulation of cilium movement (GO:0003352)7.58941173
12single fertilization (GO:0007338)7.51278176
13negative regulation of inclusion body assembly (GO:0090084)6.74427846
14fertilization (GO:0009566)6.53637209
15spermatogenesis (GO:0007283)6.48679114
16male gamete generation (GO:0048232)6.46405159
17sperm capacitation (GO:0048240)6.44221350
18DNA methylation involved in gamete generation (GO:0043046)6.27878362
19microtubule depolymerization (GO:0007019)5.96571978
20gamete generation (GO:0007276)5.94339136
21male meiosis I (GO:0007141)5.73292360
22chromosome organization involved in meiosis (GO:0070192)5.70474198
23organic cation transport (GO:0015695)5.64924386
24regulation of inclusion body assembly (GO:0090083)5.50551361
25germ cell development (GO:0007281)5.46578864
26* cellular process involved in reproduction in multicellular organism (GO:0022412)5.31666799
27ventricular system development (GO:0021591)5.12011046
28calcium ion-dependent exocytosis (GO:0017156)5.10762828
29seminiferous tubule development (GO:0072520)5.07062842
30meiotic nuclear division (GO:0007126)5.04366949
31cell recognition (GO:0008037)4.97700021
32multicellular organismal reproductive process (GO:0048609)4.66296413
33meiosis I (GO:0007127)4.62119157
34glycerol ether metabolic process (GO:0006662)4.59865170
35regulation of microtubule-based movement (GO:0060632)4.49922709
36microtubule severing (GO:0051013)4.39705025
37chromosome condensation (GO:0030261)4.26118137
38ether metabolic process (GO:0018904)4.24661210
39chaperone-mediated protein complex assembly (GO:0051131)4.22514225
40spermatid nucleus differentiation (GO:0007289)4.20388985
41genitalia morphogenesis (GO:0035112)4.19850457
42DNA packaging (GO:0006323)4.08986299
43meiotic cell cycle (GO:0051321)4.04867495
44monoubiquitinated protein deubiquitination (GO:0035520)4.03456010
45left/right pattern formation (GO:0060972)3.98846861
46protein localization to cilium (GO:0061512)3.93291661
47multicellular organismal development (GO:0007275)3.81317779
48sequestering of actin monomers (GO:0042989)3.79952019
49lactate metabolic process (GO:0006089)3.48981299
50synapsis (GO:0007129)3.45538047
51protein K11-linked deubiquitination (GO:0035871)3.43420447
52intraciliary transport (GO:0042073)3.38112807
53gene silencing by RNA (GO:0031047)3.37591158
54GTP biosynthetic process (GO:0006183)3.34039563
55meiotic cell cycle process (GO:1903046)3.30753930
56alditol metabolic process (GO:0019400)3.26593454
57protein polyglutamylation (GO:0018095)3.24961000
58polyol catabolic process (GO:0046174)3.24733704
59nucleoside diphosphate phosphorylation (GO:0006165)3.24127110
60regulation of spindle checkpoint (GO:0090231)3.16226760
61mitotic sister chromatid cohesion (GO:0007064)3.11613346
62protein refolding (GO:0042026)3.10156801
63amino-acid betaine transport (GO:0015838)3.09637373
64carnitine transport (GO:0015879)3.09637373
65single strand break repair (GO:0000012)3.08036600
66glycolytic process (GO:0006096)3.05703726
67microtubule polymerization or depolymerization (GO:0031109)3.02562309
68carnitine transmembrane transport (GO:1902603)3.01603273
69sexual reproduction (GO:0019953)3.00026256
70UTP biosynthetic process (GO:0006228)2.98896115
71axoneme assembly (GO:0035082)2.98130577
72microtubule-based movement (GO:0007018)2.95939089
73negative regulation of organelle assembly (GO:1902116)2.94043587
74regulation of meiosis I (GO:0060631)2.91491998
75cilium organization (GO:0044782)2.88513147
76glycerol metabolic process (GO:0006071)2.84058244
77cilium morphogenesis (GO:0060271)2.82164820
78nucleus organization (GO:0006997)2.80167895
79cilium assembly (GO:0042384)2.74001437
80UTP metabolic process (GO:0046051)2.72959842
81regulation of protein polyubiquitination (GO:1902914)2.72331314
82nuclear pore complex assembly (GO:0051292)2.66206510
83interferon-gamma secretion (GO:0072643)2.62264453
84* cellular component assembly involved in morphogenesis (GO:0010927)2.61567302
85gene silencing (GO:0016458)2.60788847
86regulation of centriole replication (GO:0046599)2.59363024
87centriole assembly (GO:0098534)2.51865502
88fusion of sperm to egg plasma membrane (GO:0007342)14.3802342
89sperm motility (GO:0030317)13.1562586
90sperm-egg recognition (GO:0035036)11.5150168
91cell wall macromolecule catabolic process (GO:0016998)11.4871870
92cell wall macromolecule metabolic process (GO:0044036)11.4871870
93cilium or flagellum-dependent cell motility (GO:0001539)11.2724481
94multicellular organism reproduction (GO:0032504)11.2161919
95acrosome reaction (GO:0007340)11.1361930
96plasma membrane fusion (GO:0045026)10.9513789
97binding of sperm to zona pellucida (GO:0007339)10.6976816
98* acrosome assembly (GO:0001675)10.5617645
99cell-cell recognition (GO:0009988)10.3126020
100axonemal dynein complex assembly (GO:0070286)10.1853843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.92849510
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.60500143
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.36355050
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.73593475
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68448245
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.48479248
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.48032419
8ZNF274_21170338_ChIP-Seq_K562_Hela2.38129335
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15050988
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.13968746
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.11310853
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06928912
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04450274
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6471313
15VDR_22108803_ChIP-Seq_LS180_Human1.94995634
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.93715459
17KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.85024394
18ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74774463
19RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.71900508
20TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70037678
21STAT1_17558387_ChIP-Seq_HELA_Human1.69071068
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.56375444
23GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.55388469
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55149536
25FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53306060
26KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51197854
27SOX2_22085726_ChIP-Seq_NPCs_Mouse1.48017381
28WDR5_24793694_ChIP-Seq_LNCAP_Human1.47066041
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.45891783
30KDM2B_26808549_Chip-Seq_REH_Human1.45673935
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.44781169
32GATA3_21867929_ChIP-Seq_CD8_Mouse1.44043586
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.43900020
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40862591
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40561703
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35047223
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33074117
38CBP_20019798_ChIP-Seq_JUKART_Human1.33074117
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32229003
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29419071
41LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.25500894
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.24000088
43FLI1_21867929_ChIP-Seq_TH2_Mouse1.23613542
44REST_21632747_ChIP-Seq_MESCs_Mouse1.23200541
45P53_21459846_ChIP-Seq_SAOS-2_Human1.21511643
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.17978944
47PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16694691
48CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16557762
49FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16321654
50RNF2_27304074_Chip-Seq_NSC_Mouse1.14996833
51CRX_20693478_ChIP-Seq_RETINA_Mouse1.14906328
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14604955
53SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14454503
54GF1_26923725_Chip-Seq_HPCs_Mouse1.13703995
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12218750
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10099639
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10099639
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09745351
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09578573
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09480894
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08543148
62RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07826826
63OCT4_18555785_Chip-Seq_ESCs_Mouse1.05791223
64TAF15_26573619_Chip-Seq_HEK293_Human1.05631037
65P53_22387025_ChIP-Seq_ESCs_Mouse1.05028476
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04420831
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01478158
68RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01090445
69SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00612526
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00124534
71ESET_19884257_ChIP-Seq_ESCs_Mouse0.99473623
72EZH2_27294783_Chip-Seq_NPCs_Mouse0.99217794
73CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98530114
74P300_18555785_Chip-Seq_ESCs_Mouse0.97238243
75CMYC_18555785_Chip-Seq_ESCs_Mouse0.97144449
76* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97111947
77OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95913302
78SPI1_26923725_Chip-Seq_HPCs_Mouse0.95544522
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93873490
80KLF4_18555785_Chip-Seq_ESCs_Mouse0.93232858
81* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92409158
82MYC_27129775_Chip-Seq_CORNEA_Mouse0.92224205
83LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91108950
84ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90913527
85RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90319506
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89352184
87* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89006446
88* ERG_20517297_ChIP-Seq_VCAP_Human0.88906637
89YY1_22570637_ChIP-Seq_MALME-3M_Human0.88775083
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88009314
91* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87543381
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87010733
93FLI1_21867929_ChIP-Seq_CD8_Mouse0.86771601
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86656197
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.86117055
96SOX9_26525672_Chip-Seq_HEART_Mouse0.85659689
97GF1B_26923725_Chip-Seq_HPCs_Mouse0.85312836
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.85202633
99PU1_27457419_Chip-Seq_LIVER_Mouse0.84473245
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84267922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08868670
2* MP0001929_abnormal_gametogenesis5.57890146
3MP0008877_abnormal_DNA_methylation5.35307812
4MP0002210_abnormal_sex_determination3.75646158
5MP0002161_abnormal_fertility/fecundity3.29217620
6MP0001145_abnormal_male_reproductive3.14666502
7MP0000653_abnormal_sex_gland2.73045505
8MP0002653_abnormal_ependyma_morphology2.22093139
9MP0005670_abnormal_white_adipose2.16782904
10MP0005410_abnormal_fertilization15.9290187
11MP0002160_abnormal_reproductive_system1.85382308
12MP0008057_abnormal_DNA_replication1.81464363
13MP0005623_abnormal_meninges_morphology1.48530549
14MP0003646_muscle_fatigue1.26569156
15MP0005647_abnormal_sex_gland1.22604113
16MP0002282_abnormal_trachea_morphology1.16007779
17MP0008058_abnormal_DNA_repair1.15097874
18MP0001765_abnormal_ion_homeostasis1.06730669
19MP0004233_abnormal_muscle_weight1.03780777
20MP0008995_early_reproductive_senescence1.02372858
21MP0001984_abnormal_olfaction0.95586470
22MP0003786_premature_aging0.94866936
23MP0003011_delayed_dark_adaptation0.93534314
24MP0010094_abnormal_chromosome_stability0.93460710
25MP0005389_reproductive_system_phenotype0.92281575
26MP0009046_muscle_twitch0.83083791
27MP0008007_abnormal_cellular_replicative0.82004633
28MP0002234_abnormal_pharynx_morphology0.73996564
29MP0004134_abnormal_chest_morphology0.73072506
30MP0000569_abnormal_digit_pigmentation0.72370636
31MP0003329_amyloid_beta_deposits0.57956669
32MP0005636_abnormal_mineral_homeostasis0.57646150
33MP0005377_hearing/vestibular/ear_phenot0.56497552
34MP0003878_abnormal_ear_physiology0.56497552
35MP0001545_abnormal_hematopoietic_system0.56345939
36MP0005397_hematopoietic_system_phenotyp0.56345939
37MP0010307_abnormal_tumor_latency0.51695356
38MP0000358_abnormal_cell_content/0.50596628
39MP0003699_abnormal_female_reproductive0.50471842
40MP0004036_abnormal_muscle_relaxation0.50338910
41MP0005666_abnormal_adipose_tissue0.49371636
42MP0003115_abnormal_respiratory_system0.48202909
43MP0004019_abnormal_vitamin_homeostasis0.45664978
44MP0004808_abnormal_hematopoietic_stem0.43534333
45MP0001324_abnormal_eye_pigmentation0.42609222
46MP0005253_abnormal_eye_physiology0.40874773
47MP0002928_abnormal_bile_duct0.40594492
48MP0009278_abnormal_bone_marrow0.39510487
49MP0003950_abnormal_plasma_membrane0.39476736
50MP0003111_abnormal_nucleus_morphology0.38710796
51MP0001119_abnormal_female_reproductive0.38401325
52MP0005551_abnormal_eye_electrophysiolog0.37292582
53MP0001764_abnormal_homeostasis0.37140722
54MP0001730_embryonic_growth_arrest0.35649468
55MP0001727_abnormal_embryo_implantation0.33883164
56MP0000604_amyloidosis0.32391718
57MP0002269_muscular_atrophy0.31703538
58MP0001293_anophthalmia0.31141318
59MP0006036_abnormal_mitochondrial_physio0.30181768
60MP0002139_abnormal_hepatobiliary_system0.29697477
61MP0005391_vision/eye_phenotype0.29497611
62MP0002736_abnormal_nociception_after0.28833673
63MP0009115_abnormal_fat_cell0.25832492
64MP0003879_abnormal_hair_cell0.25321965
65MP0002971_abnormal_brown_adipose0.25270133
66MP0006072_abnormal_retinal_apoptosis0.24154055
67MP0003633_abnormal_nervous_system0.24039958
68MP0004133_heterotaxia0.22675353
69MP0003077_abnormal_cell_cycle0.22585781
70MP0000313_abnormal_cell_death0.21605597
71MP0000427_abnormal_hair_cycle0.21325963
72MP0003631_nervous_system_phenotype0.19538480
73MP0001849_ear_inflammation0.19536202
74MP0004811_abnormal_neuron_physiology0.19182634
75MP0002169_no_abnormal_phenotype0.18953142
76MP0003861_abnormal_nervous_system0.18878003
77MP0002873_normal_phenotype0.18687648
78MP0002152_abnormal_brain_morphology0.17382414
79MP0000751_myopathy0.17290103
80MP0000534_abnormal_ureter_morphology0.16135614
81MP0002295_abnormal_pulmonary_circulatio0.15287034
82MP0002084_abnormal_developmental_patter0.15124970
83MP0003045_fibrosis0.14158424
84MP0002405_respiratory_system_inflammati0.13790052
85MP0003948_abnormal_gas_homeostasis0.13169775
86MP0001661_extended_life_span0.13129866
87MP0002092_abnormal_eye_morphology0.12777180
88MP0002102_abnormal_ear_morphology0.12722325
89MP0003942_abnormal_urinary_system0.12302077
90MP0000001_mammalian_phenotype0.12232419
91MP0001851_eye_inflammation0.12095385
92MP0003936_abnormal_reproductive_system0.11831192
93MP0002229_neurodegeneration0.10792210
94MP0005375_adipose_tissue_phenotype0.10791244
95MP0004084_abnormal_cardiac_muscle0.10788267
96MP0005380_embryogenesis_phenotype0.10634336
97MP0001672_abnormal_embryogenesis/_devel0.10634336
98MP0005365_abnormal_bile_salt0.10178900
99MP0002970_abnormal_white_adipose0.09844593
100MP0000432_abnormal_head_morphology0.09570286

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.72861415
2Abnormal respiratory motile cilium morphology (HP:0005938)9.23490821
3Abnormal respiratory epithelium morphology (HP:0012253)9.23490821
4Abnormal ciliary motility (HP:0012262)7.90309024
5Rhinitis (HP:0012384)7.77784879
6Chronic bronchitis (HP:0004469)7.77038519
7Infertility (HP:0000789)6.59428767
8Nasal polyposis (HP:0100582)6.33154264
9Abnormality of the nasal mucosa (HP:0000433)5.20573630
10Bronchitis (HP:0012387)4.46281659
11Bronchiectasis (HP:0002110)4.42201126
12Nephronophthisis (HP:0000090)4.18087092
13Male infertility (HP:0003251)3.89173673
14Recurrent sinusitis (HP:0011108)3.65785458
15Recurrent otitis media (HP:0000403)3.20648526
16Abnormal spermatogenesis (HP:0008669)3.20228552
17Abnormality of the renal medulla (HP:0100957)3.17146780
18Abnormality of the lower motor neuron (HP:0002366)2.97220689
19Gonadotropin excess (HP:0000837)2.91009006
20Tubulointerstitial nephritis (HP:0001970)2.84670858
21Molar tooth sign on MRI (HP:0002419)2.60901668
22Abnormality of midbrain morphology (HP:0002418)2.60901668
23Fibular hypoplasia (HP:0003038)2.52922853
24Tubular atrophy (HP:0000092)2.49152154
25Medial flaring of the eyebrow (HP:0010747)2.49079389
26Tubulointerstitial abnormality (HP:0001969)2.39596977
27Amyotrophic lateral sclerosis (HP:0007354)2.35307483
28Azoospermia (HP:0000027)2.27684587
29Recurrent bronchitis (HP:0002837)2.25777086
30Impulsivity (HP:0100710)2.05577942
31Dynein arm defect of respiratory motile cilia (HP:0012255)13.5343313
32Absent/shortened dynein arms (HP:0200106)13.5343313
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4786636
34Postaxial foot polydactyly (HP:0001830)1.93596672
35Tubulointerstitial fibrosis (HP:0005576)1.90412951
36Stage 5 chronic kidney disease (HP:0003774)1.89873325
37Impaired proprioception (HP:0010831)1.82349896
38Abnormality of the renal cortex (HP:0011035)1.77133917
39Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76514726
40Congenital hepatic fibrosis (HP:0002612)1.76060167
41Polydipsia (HP:0001959)1.70271540
42Abnormal drinking behavior (HP:0030082)1.70271540
43Upper motor neuron abnormality (HP:0002127)1.69015774
44Abnormality of the dental root (HP:0006486)1.68612092
45Taurodontia (HP:0000679)1.68612092
46Abnormality of permanent molar morphology (HP:0011071)1.68612092
47Oculomotor apraxia (HP:0000657)1.67512121
48Abnormality of dentin (HP:0010299)1.65844432
49Dyschromatopsia (HP:0007641)1.63761956
5011 pairs of ribs (HP:0000878)1.63363806
51Short ribs (HP:0000773)1.61154915
52Aplasia/Hypoplasia of the fibula (HP:0006492)1.59284960
53Abnormal gallbladder physiology (HP:0012438)1.58857841
54Cholecystitis (HP:0001082)1.58857841
55Abnormality of renal excretion (HP:0011036)1.58708311
56Abnormality of molar morphology (HP:0011070)1.56315619
57Abnormality of molar (HP:0011077)1.56315619
58Absent frontal sinuses (HP:0002688)1.55564859
59Abnormality of the dental pulp (HP:0006479)1.54782659
60Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53730339
61Renal dysplasia (HP:0000110)1.53045685
62Chronic sinusitis (HP:0011109)1.52757148
63Facial cleft (HP:0002006)1.50119602
64Postaxial hand polydactyly (HP:0001162)1.48178703
65Spastic tetraparesis (HP:0001285)1.46094493
66Abnormality of the anterior horn cell (HP:0006802)1.45634953
67Degeneration of anterior horn cells (HP:0002398)1.45634953
68Microglossia (HP:0000171)1.44810755
69Cystic liver disease (HP:0006706)1.44115396
70J-shaped sella turcica (HP:0002680)1.43865719
71Supernumerary spleens (HP:0009799)1.42469333
72Breast carcinoma (HP:0003002)1.41137780
73Absent epiphyses (HP:0010577)1.38275799
74Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38275799
75Congenital primary aphakia (HP:0007707)1.36788871
76Gait imbalance (HP:0002141)1.36468795
77Decreased central vision (HP:0007663)1.36023967
78Heterotopia (HP:0002282)1.34774432
79Large eyes (HP:0001090)1.34048179
80Aplasia/Hypoplasia of the tongue (HP:0010295)1.33500954
81Broad distal phalanx of finger (HP:0009836)1.33026009
82Abnormal biliary tract physiology (HP:0012439)1.32535135
83Bile duct proliferation (HP:0001408)1.32535135
84Aplasia/Hypoplasia of the lens (HP:0008063)1.31047100
85Bell-shaped thorax (HP:0001591)1.31035853
86Pancreatic fibrosis (HP:0100732)1.31028080
87Selective tooth agenesis (HP:0001592)1.30974828
88Hypoplasia of dental enamel (HP:0006297)1.27245748
89Choroideremia (HP:0001139)1.26301065
90Deformed sella turcica (HP:0002681)1.24413577
91Short thorax (HP:0010306)1.22857871
92Nephropathy (HP:0000112)1.22066016
93Median cleft lip (HP:0000161)1.21542688
94Abnormal urine output (HP:0012590)1.21376715
95Hemorrhage of the eye (HP:0011885)1.20085889
96Vascular calcification (HP:0004934)1.18484838
97True hermaphroditism (HP:0010459)1.17914686
98Nephrogenic diabetes insipidus (HP:0009806)1.14910333
99Short nail (HP:0001799)1.13123652
100Exercise-induced myalgia (HP:0003738)1.12716398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.34064890
2PDK49.34064890
3PDK26.08104672
4TESK14.53950707
5PRKD33.61667200
6ICK3.27054061
7PTK2B2.31546618
8WNK42.17995523
9STK392.10451242
10PNCK1.95984895
11NEK21.71386910
12STK381.33583857
13PDK11.06340463
14DYRK1B1.04446603
15TYRO30.92681674
16WNK10.90056272
17MAPK150.85681425
18PASK0.81907876
19DYRK30.80115558
20CCNB10.77897810
21STK30.77474225
22IRAK10.66667172
23TTK0.61319445
24CDC70.59668194
25PINK10.58065839
26MAP2K60.52985915
27TESK20.49111324
28PDPK10.48312525
29LMTK20.47503876
30CHEK20.47202246
31FRK0.46815432
32CHEK10.43765598
33ATR0.43712517
34WEE10.41866504
35EEF2K0.38128354
36CAMK1G0.37682936
37STK38L0.35377547
38NTRK20.33944296
39ATM0.30965415
40RIPK40.30896607
41PAK10.29255755
42PRKCG0.26252206
43MUSK0.22607236
44IRAK20.22531834
45MAPKAPK50.21857821
46PAK20.21482539
47PLK40.21361949
48CAMKK10.21361162
49MTOR0.21042672
50MAP3K100.20403438
51PLK10.19037953
52PRKAA10.17359527
53RPS6KB10.14133398
54CDK120.13653895
55BMPR1B0.11451620
56MARK20.10700285
57WNK30.10620632
58BRAF0.10236504
59NEK60.09240251
60CDK150.08844272
61BRSK20.08794173
62STK100.08601195
63PRKCZ0.08440028
64PRKG10.08075644
65CSNK2A10.06917660
66CDK180.06897306
67PRKCQ0.06885967
68PRKACG0.06577017
69PAK40.06166776
70PRKG20.05850778
71MAP3K40.05340207
72CDK11A0.05225645
73CSNK1D0.04874089
74CSF1R0.04793371
75MARK30.04011548
76RPS6KA10.03998196
77CDK10.03608547
78CDK140.02960041
79MAPK80.02658922
80GSK3B0.02300684
81CDK20.02245082
82PRKDC0.01067283
83PKN10.00765900
84PRKCB0.00486819
85PRKACB0.00317159
86PTK60.00123719
87RIPK1-0.0493505
88INSR-0.0460475
89BUB1-0.0398898
90PRKACA-0.0393394
91STK11-0.0379079
92PRKCD-0.0347345
93CAMK2A-0.0261085
94PAK6-0.0242370
95CSK-0.0236079
96RPS6KA3-0.0197044
97PRKCA-0.0183649
98EGFR-0.0171029
99BRSK1-0.0104450
100CSNK2A2-0.0002986

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.40029981
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.46399953
3Pyruvate metabolism_Homo sapiens_hsa006204.41165870
4Fatty acid biosynthesis_Homo sapiens_hsa000613.80020404
5Propanoate metabolism_Homo sapiens_hsa006403.57037818
6Glucagon signaling pathway_Homo sapiens_hsa049222.93709877
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.57384332
8Basal transcription factors_Homo sapiens_hsa030222.54084629
9Linoleic acid metabolism_Homo sapiens_hsa005912.49390217
10Selenocompound metabolism_Homo sapiens_hsa004502.39924937
11Pentose phosphate pathway_Homo sapiens_hsa000302.39251604
12Glycerolipid metabolism_Homo sapiens_hsa005611.97713800
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.92140182
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89758253
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.85316373
16Oocyte meiosis_Homo sapiens_hsa041141.84594000
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84593797
18Fanconi anemia pathway_Homo sapiens_hsa034601.80508235
19PPAR signaling pathway_Homo sapiens_hsa033201.79135248
20Dorso-ventral axis formation_Homo sapiens_hsa043201.75106258
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.69387663
22Amphetamine addiction_Homo sapiens_hsa050311.58784148
23Carbon metabolism_Homo sapiens_hsa012001.46025085
24Renin secretion_Homo sapiens_hsa049241.34625951
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33867786
26Fructose and mannose metabolism_Homo sapiens_hsa000511.31637964
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.28309274
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24814630
29Huntingtons disease_Homo sapiens_hsa050161.20906372
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18303012
31Fat digestion and absorption_Homo sapiens_hsa049751.17988356
32Cardiac muscle contraction_Homo sapiens_hsa042601.17920258
33Fatty acid metabolism_Homo sapiens_hsa012121.14985245
34Fatty acid degradation_Homo sapiens_hsa000711.12633835
35Antigen processing and presentation_Homo sapiens_hsa046121.08628387
36Mineral absorption_Homo sapiens_hsa049781.07593200
37Ether lipid metabolism_Homo sapiens_hsa005651.07186446
38mRNA surveillance pathway_Homo sapiens_hsa030151.04819595
39Biosynthesis of amino acids_Homo sapiens_hsa012301.01600411
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00402796
41Purine metabolism_Homo sapiens_hsa002300.96423541
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94797147
43RNA transport_Homo sapiens_hsa030130.94696208
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90326234
45Long-term potentiation_Homo sapiens_hsa047200.88154194
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84772507
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80587468
48Glutathione metabolism_Homo sapiens_hsa004800.80332281
49Collecting duct acid secretion_Homo sapiens_hsa049660.78415916
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74826254
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74154648
52Chemical carcinogenesis_Homo sapiens_hsa052040.71176582
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71024381
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67192620
55ABC transporters_Homo sapiens_hsa020100.64525821
56Estrogen signaling pathway_Homo sapiens_hsa049150.62356457
57VEGF signaling pathway_Homo sapiens_hsa043700.60951491
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.60904400
59Arachidonic acid metabolism_Homo sapiens_hsa005900.60432583
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56211154
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.54978292
62Hedgehog signaling pathway_Homo sapiens_hsa043400.54112711
63Legionellosis_Homo sapiens_hsa051340.52359841
64Calcium signaling pathway_Homo sapiens_hsa040200.51075699
65Insulin secretion_Homo sapiens_hsa049110.49730419
66Thyroid hormone synthesis_Homo sapiens_hsa049180.47729294
67Bile secretion_Homo sapiens_hsa049760.42931377
68Metabolic pathways_Homo sapiens_hsa011000.36187659
69AMPK signaling pathway_Homo sapiens_hsa041520.35374163
70B cell receptor signaling pathway_Homo sapiens_hsa046620.35040792
71Systemic lupus erythematosus_Homo sapiens_hsa053220.34878335
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31518632
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.31508974
74Endocytosis_Homo sapiens_hsa041440.29283137
75Pancreatic secretion_Homo sapiens_hsa049720.29103529
76Inositol phosphate metabolism_Homo sapiens_hsa005620.28311086
77Salivary secretion_Homo sapiens_hsa049700.27991966
78N-Glycan biosynthesis_Homo sapiens_hsa005100.27821187
79Synaptic vesicle cycle_Homo sapiens_hsa047210.27643359
80Renin-angiotensin system_Homo sapiens_hsa046140.27412545
81Protein digestion and absorption_Homo sapiens_hsa049740.26146611
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25926085
83Sulfur metabolism_Homo sapiens_hsa009200.23871785
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23155989
85Pyrimidine metabolism_Homo sapiens_hsa002400.22433392
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21929013
87Gastric acid secretion_Homo sapiens_hsa049710.19763747
88cAMP signaling pathway_Homo sapiens_hsa040240.18820208
89Wnt signaling pathway_Homo sapiens_hsa043100.18699711
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18566728
91Cell cycle_Homo sapiens_hsa041100.18424882
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18038097
93Circadian entrainment_Homo sapiens_hsa047130.13444183
94Homologous recombination_Homo sapiens_hsa034400.12231099
95Taste transduction_Homo sapiens_hsa047420.11629777
96Alcoholism_Homo sapiens_hsa050340.11608257
97Retinol metabolism_Homo sapiens_hsa008300.11031939
98Viral carcinogenesis_Homo sapiens_hsa052030.10643939
99Salmonella infection_Homo sapiens_hsa051320.08204444
100RNA degradation_Homo sapiens_hsa030180.06691990

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