FABP5P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein-chromophore linkage (GO:0018298)6.55129114
2platelet dense granule organization (GO:0060155)5.75510012
3cullin deneddylation (GO:0010388)5.62303949
4water-soluble vitamin biosynthetic process (GO:0042364)5.33026671
5protein deneddylation (GO:0000338)5.24717253
6protein neddylation (GO:0045116)5.08590844
7behavioral response to nicotine (GO:0035095)5.00283801
8phosphorylated carbohydrate dephosphorylation (GO:0046838)4.22286863
9inositol phosphate dephosphorylation (GO:0046855)4.22286863
10proline transport (GO:0015824)4.21788430
11L-ascorbic acid metabolic process (GO:0019852)4.14242742
12inositol phosphate catabolic process (GO:0071545)3.80166379
13regulation of prostaglandin secretion (GO:0032306)3.75365445
14fucose catabolic process (GO:0019317)3.72271348
15L-fucose metabolic process (GO:0042354)3.72271348
16L-fucose catabolic process (GO:0042355)3.72271348
17rhodopsin mediated signaling pathway (GO:0016056)3.69497824
18exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.57102174
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51251086
20positive regulation of prostaglandin secretion (GO:0032308)3.43282272
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.36328826
22indolalkylamine metabolic process (GO:0006586)3.34413623
23dopamine transport (GO:0015872)3.34250793
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33190212
25phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.28889542
26early endosome to late endosome transport (GO:0045022)3.26643226
27DNA replication-dependent nucleosome assembly (GO:0006335)3.24373158
28DNA replication-dependent nucleosome organization (GO:0034723)3.24373158
29indole-containing compound catabolic process (GO:0042436)3.22592874
30indolalkylamine catabolic process (GO:0046218)3.22592874
31tryptophan catabolic process (GO:0006569)3.22592874
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21859393
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.21859393
34NADH dehydrogenase complex assembly (GO:0010257)3.21859393
35mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.20247743
36positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.20247743
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.17228495
38kynurenine metabolic process (GO:0070189)3.17046971
39establishment of protein localization to Golgi (GO:0072600)3.15761271
40ubiquinone metabolic process (GO:0006743)3.09663683
41protein targeting to Golgi (GO:0000042)3.08232465
42protein-cofactor linkage (GO:0018065)3.05550729
43response to misfolded protein (GO:0051788)3.05373214
44anterograde synaptic vesicle transport (GO:0048490)3.04023403
45ADP metabolic process (GO:0046031)3.01850091
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.01486183
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01486183
48negative regulation of heart rate (GO:0010459)3.00403515
49mitochondrial respiratory chain complex assembly (GO:0033108)3.00262122
50piRNA metabolic process (GO:0034587)2.98502640
51positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.97783757
52protein complex biogenesis (GO:0070271)2.93815095
53UTP metabolic process (GO:0046051)2.93358859
54regulation of vesicle fusion (GO:0031338)2.93133392
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91758598
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91758598
57regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.89435765
58ubiquinone biosynthetic process (GO:0006744)2.89252351
59DNA deamination (GO:0045006)2.86705637
60reflex (GO:0060004)2.84741843
61negative regulation of mast cell activation (GO:0033004)2.84268298
62regulation of sequestering of triglyceride (GO:0010889)2.79275072
63positive regulation of fatty acid transport (GO:2000193)2.78182180
64vitamin transmembrane transport (GO:0035461)2.76610381
65GTP biosynthetic process (GO:0006183)2.76577360
66maturation of 5.8S rRNA (GO:0000460)2.76195512
67regulation of memory T cell differentiation (GO:0043380)2.73621179
68protein localization to Golgi apparatus (GO:0034067)2.72701617
69photoreceptor cell maintenance (GO:0045494)2.72484138
70transepithelial transport (GO:0070633)2.69770707
71polyol catabolic process (GO:0046174)2.67602961
72regulation of isotype switching to IgG isotypes (GO:0048302)2.67143298
73postreplication repair (GO:0006301)2.65950573
74alanine transport (GO:0032328)2.65944089
75negative regulation of DNA-dependent DNA replication (GO:2000104)2.63575375
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63485751
77regulation of mitotic spindle checkpoint (GO:1903504)2.63485751
78regulation of action potential (GO:0098900)2.63407068
79retrograde transport, vesicle recycling within Golgi (GO:0000301)2.61402643
80UTP biosynthetic process (GO:0006228)2.59656082
81peptidyl-histidine modification (GO:0018202)2.58971366
82chaperone-mediated protein transport (GO:0072321)2.58054198
83regulation of cytokine production involved in inflammatory response (GO:1900015)2.57406638
84electron transport chain (GO:0022900)2.57345311
85DNA damage induced protein phosphorylation (GO:0006975)2.57009750
86primary amino compound metabolic process (GO:1901160)2.56554773
87axoneme assembly (GO:0035082)2.56192589
88serotonin metabolic process (GO:0042428)2.55149752
89respiratory chain complex IV assembly (GO:0008535)2.54192492
90respiratory electron transport chain (GO:0022904)2.53513035
91inositol metabolic process (GO:0006020)2.53395315
92anterograde axon cargo transport (GO:0008089)2.52621309
93proteasome assembly (GO:0043248)2.51588807
94indole-containing compound metabolic process (GO:0042430)2.49849633
95detection of light stimulus involved in sensory perception (GO:0050962)2.48932347
96detection of light stimulus involved in visual perception (GO:0050908)2.48932347
97aggressive behavior (GO:0002118)2.48849492
98epithelial cilium movement (GO:0003351)2.48796244
99positive regulation of icosanoid secretion (GO:0032305)2.48394439
100estrogen biosynthetic process (GO:0006703)2.44529794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.88643138
2VDR_22108803_ChIP-Seq_LS180_Human3.84121612
3IGF1R_20145208_ChIP-Seq_DFB_Human3.14516268
4ZNF274_21170338_ChIP-Seq_K562_Hela3.06793493
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.64207207
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.58466665
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57409757
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50597887
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48969367
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.39090326
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32845321
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28768083
13TAF15_26573619_Chip-Seq_HEK293_Human2.18041887
14EWS_26573619_Chip-Seq_HEK293_Human2.17646880
15FUS_26573619_Chip-Seq_HEK293_Human2.16729790
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15757659
17GBX2_23144817_ChIP-Seq_PC3_Human2.08406553
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08308558
19ER_23166858_ChIP-Seq_MCF-7_Human2.04457182
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03160209
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.02447892
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90721084
23EZH2_22144423_ChIP-Seq_EOC_Human1.90019164
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87243213
25ELK1_19687146_ChIP-ChIP_HELA_Human1.84469613
26P300_19829295_ChIP-Seq_ESCs_Human1.78914675
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73344885
28SOX2_19829295_ChIP-Seq_ESCs_Human1.67315408
29NANOG_19829295_ChIP-Seq_ESCs_Human1.67315408
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.65603316
31BCAT_22108803_ChIP-Seq_LS180_Human1.59529295
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59308431
33VDR_23849224_ChIP-Seq_CD4+_Human1.58974331
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58386305
35MYC_18940864_ChIP-ChIP_HL60_Human1.55671342
36TP53_22573176_ChIP-Seq_HFKS_Human1.53123602
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.52813753
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52394477
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.52394477
40IRF1_19129219_ChIP-ChIP_H3396_Human1.51620791
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.49429485
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47164852
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46698212
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45374210
45AR_21572438_ChIP-Seq_LNCaP_Human1.44253826
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40767829
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36972203
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33410535
49CRX_20693478_ChIP-Seq_RETINA_Mouse1.33384817
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.32998091
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31304687
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30572849
53TCF4_22108803_ChIP-Seq_LS180_Human1.30277946
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27489945
55AR_20517297_ChIP-Seq_VCAP_Human1.24052992
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22623701
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.21008865
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18179146
59FOXP3_21729870_ChIP-Seq_TREG_Human1.15852436
60STAT3_23295773_ChIP-Seq_U87_Human1.15459492
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14537492
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.14196745
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13597191
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.12771432
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12227220
66AR_25329375_ChIP-Seq_VCAP_Human1.12166005
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10929119
68NMYC_18555785_Chip-Seq_ESCs_Mouse1.10662871
69SMAD4_21799915_ChIP-Seq_A2780_Human1.10634106
70TCF4_23295773_ChIP-Seq_U87_Human1.10503809
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.09936547
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.09183926
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07946278
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.07574776
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07445818
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.06902016
77HTT_18923047_ChIP-ChIP_STHdh_Human1.05638961
78P53_22387025_ChIP-Seq_ESCs_Mouse1.05459777
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05308224
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.05266216
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.04984065
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04431352
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04038599
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03809401
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03588240
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03487251
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02267813
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02174148
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01773377
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01620102
91MYC_19829295_ChIP-Seq_ESCs_Human0.99939266
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99378470
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98837595
94ERG_20517297_ChIP-Seq_VCAP_Human0.98295428
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97966645
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97966645
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97935346
98SOX2_18555785_Chip-Seq_ESCs_Mouse0.97461531
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.95948554
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95893697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex6.62242582
2MP0003011_delayed_dark_adaptation6.08225563
3MP0005083_abnormal_biliary_tract5.87335831
4MP0005084_abnormal_gallbladder_morpholo5.23057940
5MP0005085_abnormal_gallbladder_physiolo3.68375988
6MP0005365_abnormal_bile_salt3.08767688
7MP0006072_abnormal_retinal_apoptosis2.52252711
8MP0002138_abnormal_hepatobiliary_system2.35077628
9MP0001502_abnormal_circadian_rhythm2.23125045
10MP0001764_abnormal_homeostasis2.17916241
11MP0005253_abnormal_eye_physiology2.14328454
12MP0002736_abnormal_nociception_after2.09755868
13MP0000569_abnormal_digit_pigmentation2.08103555
14MP0005379_endocrine/exocrine_gland_phen1.96897471
15MP0002928_abnormal_bile_duct1.93305722
16MP0005551_abnormal_eye_electrophysiolog1.92657541
17MP0005646_abnormal_pituitary_gland1.87685222
18MP0001968_abnormal_touch/_nociception1.85681004
19MP0006292_abnormal_olfactory_placode1.84346093
20MP0002102_abnormal_ear_morphology1.76580924
21MP0009046_muscle_twitch1.66760163
22MP0006276_abnormal_autonomic_nervous1.64604146
23MP0008058_abnormal_DNA_repair1.55170893
24MP0008875_abnormal_xenobiotic_pharmacok1.47234760
25MP0002160_abnormal_reproductive_system1.46368940
26MP0003195_calcinosis1.46346754
27MP0002837_dystrophic_cardiac_calcinosis1.42516684
28MP0008872_abnormal_physiological_respon1.42488636
29MP0001905_abnormal_dopamine_level1.40315967
30MP0003252_abnormal_bile_duct1.37340015
31MP0008877_abnormal_DNA_methylation1.37027522
32MP0001501_abnormal_sleep_pattern1.36230474
33MP0010386_abnormal_urinary_bladder1.34280950
34MP0006082_CNS_inflammation1.33209209
35MP0002909_abnormal_adrenal_gland1.31042517
36MP0000230_abnormal_systemic_arterial1.29066421
37MP0004145_abnormal_muscle_electrophysio1.21089599
38MP0009745_abnormal_behavioral_response1.19226439
39MP0002272_abnormal_nervous_system1.10281034
40MP0005075_abnormal_melanosome_morpholog1.04834022
41MP0003718_maternal_effect1.00607474
42MP0002572_abnormal_emotion/affect_behav0.99263944
43MP0001529_abnormal_vocalization0.98516233
44MP0005670_abnormal_white_adipose0.95912723
45MP0003693_abnormal_embryo_hatching0.95394345
46MP0002938_white_spotting0.93876764
47MP0003943_abnormal_hepatobiliary_system0.89381660
48MP0000372_irregular_coat_pigmentation0.88394292
49MP0005671_abnormal_response_to0.87708878
50MP0003303_peritoneal_inflammation0.86984153
51MP0002064_seizures0.85821628
52MP0005389_reproductive_system_phenotype0.85187064
53MP0004147_increased_porphyrin_level0.84952407
54MP0004215_abnormal_myocardial_fiber0.84064919
55MP0000427_abnormal_hair_cycle0.83732796
56MP0002163_abnormal_gland_morphology0.83244319
57MP0001835_abnormal_antigen_presentation0.82857089
58MP0001986_abnormal_taste_sensitivity0.82461277
59MP0000685_abnormal_immune_system0.80404171
60MP0004019_abnormal_vitamin_homeostasis0.80093552
61MP0004885_abnormal_endolymph0.79637182
62MP0005174_abnormal_tail_pigmentation0.79399294
63MP0003137_abnormal_impulse_conducting0.79076004
64MP0002693_abnormal_pancreas_physiology0.77438872
65MP0005595_abnormal_vascular_smooth0.77329611
66MP0004142_abnormal_muscle_tone0.76911655
67MP0002733_abnormal_thermal_nociception0.75127329
68MP0002184_abnormal_innervation0.73290286
69MP0005410_abnormal_fertilization0.72593206
70MP0003136_yellow_coat_color0.72152904
71MP0005195_abnormal_posterior_eye0.70635294
72MP0002229_neurodegeneration0.69869631
73MP0002752_abnormal_somatic_nervous0.69508474
74MP0005220_abnormal_exocrine_pancreas0.68192525
75MP0005391_vision/eye_phenotype0.68169570
76MP0001664_abnormal_digestion0.68059547
77MP0005645_abnormal_hypothalamus_physiol0.67772676
78MP0001970_abnormal_pain_threshold0.67674170
79MP0002557_abnormal_social/conspecific_i0.63310560
80MP0008775_abnormal_heart_ventricle0.62866118
81MP0001663_abnormal_digestive_system0.62323420
82MP0006036_abnormal_mitochondrial_physio0.61823351
83MP0000639_abnormal_adrenal_gland0.61410160
84MP0002090_abnormal_vision0.59900160
85MP0000631_abnormal_neuroendocrine_gland0.58894870
86MP0009764_decreased_sensitivity_to0.56841298
87MP0002234_abnormal_pharynx_morphology0.56002659
88MP0005187_abnormal_penis_morphology0.55249334
89MP0002210_abnormal_sex_determination0.54678646
90MP0004133_heterotaxia0.54551669
91MP0004043_abnormal_pH_regulation0.53785379
92MP0001440_abnormal_grooming_behavior0.53172947
93MP0005167_abnormal_blood-brain_barrier0.52952023
94MP0009765_abnormal_xenobiotic_induced0.52609527
95MP0004742_abnormal_vestibular_system0.52505291
96MP0008873_increased_physiological_sensi0.52089220
97MP0010094_abnormal_chromosome_stability0.51278473
98MP0003890_abnormal_embryonic-extraembry0.50934628
99MP0005636_abnormal_mineral_homeostasis0.50807897
100MP0001119_abnormal_female_reproductive0.50529131

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.72968924
2Acute necrotizing encephalopathy (HP:0006965)3.53372451
3Nephronophthisis (HP:0000090)3.40698805
4Azoospermia (HP:0000027)3.38370654
5Congenital stationary night blindness (HP:0007642)3.28870103
6Abolished electroretinogram (ERG) (HP:0000550)3.18184857
7Increased CSF lactate (HP:0002490)3.17930754
8Mitochondrial inheritance (HP:0001427)3.14796073
9Pendular nystagmus (HP:0012043)3.12028206
10Abnormality of midbrain morphology (HP:0002418)3.07712244
11Molar tooth sign on MRI (HP:0002419)3.07712244
12Pancreatic fibrosis (HP:0100732)3.07026389
13Stomatitis (HP:0010280)3.05494802
14Abnormality of the renal cortex (HP:0011035)2.98432674
15Acute encephalopathy (HP:0006846)2.97963302
16Abnormal mitochondria in muscle tissue (HP:0008316)2.95335877
17Progressive macrocephaly (HP:0004481)2.94595119
18Abnormal rod and cone electroretinograms (HP:0008323)2.89583560
19True hermaphroditism (HP:0010459)2.80191188
20Hyperventilation (HP:0002883)2.79814376
21Abnormality of the renal medulla (HP:0100957)2.72321216
22Hepatic necrosis (HP:0002605)2.72059396
23Hepatocellular necrosis (HP:0001404)2.69694767
24Abnormal spermatogenesis (HP:0008669)2.68840623
25Attenuation of retinal blood vessels (HP:0007843)2.65681910
26Abnormal hair whorl (HP:0010721)2.59109309
27Congenital, generalized hypertrichosis (HP:0004540)2.51559288
28Distal arthrogryposis (HP:0005684)2.50359486
29Tubular atrophy (HP:0000092)2.48484482
30Bile duct proliferation (HP:0001408)2.46487815
31Abnormal biliary tract physiology (HP:0012439)2.46487815
32Hypoplasia of the fovea (HP:0007750)2.37253003
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.37253003
34Abnormality of alanine metabolism (HP:0010916)2.27742974
35Hyperalaninemia (HP:0003348)2.27742974
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27742974
37Abnormality of the pons (HP:0007361)2.26164576
38Abnormal respiratory epithelium morphology (HP:0012253)2.25339850
39Abnormal respiratory motile cilium morphology (HP:0005938)2.25339850
40Microretrognathia (HP:0000308)2.23049155
41Colon cancer (HP:0003003)2.20690551
42Diastasis recti (HP:0001540)2.19035212
43Type II lissencephaly (HP:0007260)2.15868977
44Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.15309118
45Short 1st metacarpal (HP:0010034)2.15309118
46Mesangial abnormality (HP:0001966)2.14445850
47Hypoproteinemia (HP:0003075)2.13099059
48CNS demyelination (HP:0007305)2.12610033
49Medial flaring of the eyebrow (HP:0010747)2.11793802
50Increased hepatocellular lipid droplets (HP:0006565)2.11629233
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.10343140
52Absent/shortened dynein arms (HP:0200106)2.10343140
53Inability to walk (HP:0002540)2.09864397
54Hypoplasia of the pons (HP:0012110)2.08105891
55Abnormal ciliary motility (HP:0012262)2.07983857
56Cerebral edema (HP:0002181)2.06912292
57Tetraplegia (HP:0002445)2.06836670
583-Methylglutaconic aciduria (HP:0003535)2.06699722
59Renal cortical cysts (HP:0000803)2.06247950
60Decreased central vision (HP:0007663)2.06097545
61Limb dystonia (HP:0002451)2.05557912
62Bony spicule pigmentary retinopathy (HP:0007737)2.04193187
63Progressive inability to walk (HP:0002505)2.03500409
64Stomach cancer (HP:0012126)2.00887133
65Genetic anticipation (HP:0003743)2.00386538
66Lipid accumulation in hepatocytes (HP:0006561)1.98385079
67Aplasia/Hypoplasia of the tibia (HP:0005772)1.98309672
68Increased corneal curvature (HP:0100692)1.98139857
69Keratoconus (HP:0000563)1.98139857
70Abnormal drinking behavior (HP:0030082)1.97560928
71Polydipsia (HP:0001959)1.97560928
72Sclerocornea (HP:0000647)1.97304695
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96791463
74Constricted visual fields (HP:0001133)1.94802490
75Progressive microcephaly (HP:0000253)1.94515949
76Increased serum lactate (HP:0002151)1.94263601
77Anencephaly (HP:0002323)1.93192634
78Renal Fanconi syndrome (HP:0001994)1.92857814
79IgG deficiency (HP:0004315)1.91959241
80Generalized aminoaciduria (HP:0002909)1.89104585
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.89025473
82Abnormality of the 1st metacarpal (HP:0010009)1.88462704
83Abnormality of renal resorption (HP:0011038)1.86353024
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85689088
85Pachygyria (HP:0001302)1.84904704
86Abnormal respiratory motile cilium physiology (HP:0012261)1.83148842
87Broad hallux (HP:0010055)1.83057059
88Abnormality of the corticospinal tract (HP:0002492)1.82601941
89Adactyly (HP:0009776)1.81190880
90Thyroid-stimulating hormone excess (HP:0002925)1.80741712
91Lethargy (HP:0001254)1.80512806
92Optic disc pallor (HP:0000543)1.79396347
93Methylmalonic acidemia (HP:0002912)1.79062184
94Short tibia (HP:0005736)1.78351556
95Cystic liver disease (HP:0006706)1.77964843
96Hypothermia (HP:0002045)1.77534476
97Abnormality of the phalanges of the 5th finger (HP:0004213)1.77005165
98Poor speech (HP:0002465)1.76353213
99Progressive cerebellar ataxia (HP:0002073)1.75810142
100Cortical visual impairment (HP:0100704)1.74402714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME17.12764473
2ZAK4.13816311
3MAP4K23.74085891
4FRK3.46511997
5PINK13.31482951
6NUAK12.90705349
7TIE12.45126390
8GRK12.40485392
9PIK3CG2.30637180
10ADRBK21.86984399
11TLK11.83313295
12WNK41.75405700
13OXSR11.73190486
14MST41.65899844
15CSNK1G31.63988695
16EIF2AK11.61763398
17WNK31.57877405
18EIF2AK31.54901006
19CSNK1G11.49408163
20BMPR1B1.43906837
21CSNK1G21.37784568
22TSSK61.35748759
23TEC1.32670761
24ACVR1B1.31182037
25STK391.27830037
26MAPKAPK31.18293987
27TXK1.17109444
28PHKG11.12614455
29PHKG21.12614455
30DYRK21.10617935
31MAPK131.10451454
32MAP2K71.03485259
33MAP3K41.02362462
34MAP2K60.99931995
35VRK20.99834421
36PLK30.93217097
37SRPK10.90344169
38TNK20.88858790
39EIF2AK20.85147152
40TAOK30.77084170
41CDK190.76607879
42ERBB30.75212545
43PBK0.73984289
44RPS6KA50.72962295
45LATS10.71882762
46VRK10.67162693
47ITK0.66041970
48INSRR0.64495213
49PRKCG0.64414477
50NTRK20.63744180
51TTK0.63073214
52STK30.60479353
53PIK3CA0.57513786
54PRKCQ0.57251371
55TRIM280.57044648
56BCR0.56720738
57IKBKB0.56460357
58PLK40.54823496
59PTK2B0.54480852
60NEK10.54048697
61ADRBK10.52995121
62PRKCE0.52964203
63MAP3K120.52506126
64NEK90.52149555
65BUB10.50692229
66PLK20.49446914
67CSNK1A1L0.49275528
68RPS6KA40.48899165
69DAPK20.48793563
70CSNK1A10.48311060
71PLK10.47982623
72MKNK20.46149398
73TGFBR10.45320466
74NTRK30.45167755
75MINK10.43728466
76WEE10.43322750
77IKBKE0.42355726
78TNIK0.39518260
79PRKACA0.37767872
80CSNK2A10.36990272
81CAMK2A0.36511175
82PIM20.36315998
83RPS6KB10.36286568
84PKN10.36237154
85BCKDK0.36075817
86CSNK1E0.35266535
87STK160.35038167
88PAK30.34853387
89MKNK10.34767536
90MYLK0.33266081
91AURKA0.31667339
92CASK0.30935848
93FLT30.30019750
94OBSCN0.29646573
95CHEK20.29180171
96TAF10.26830806
97RPS6KA60.25857594
98ATR0.25121659
99STK38L0.25039463
100CAMK10.24982986

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.83309672
2Proteasome_Homo sapiens_hsa030502.61415703
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.41654431
4Parkinsons disease_Homo sapiens_hsa050122.38130097
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.35476790
6Phototransduction_Homo sapiens_hsa047442.15436121
7Linoleic acid metabolism_Homo sapiens_hsa005912.06396491
8Nitrogen metabolism_Homo sapiens_hsa009101.99708949
9Protein export_Homo sapiens_hsa030601.99509366
10Selenocompound metabolism_Homo sapiens_hsa004501.99080866
11Asthma_Homo sapiens_hsa053101.91036456
12One carbon pool by folate_Homo sapiens_hsa006701.90981726
13RNA polymerase_Homo sapiens_hsa030201.83300030
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82872127
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.82030574
16Homologous recombination_Homo sapiens_hsa034401.69604981
17Huntingtons disease_Homo sapiens_hsa050161.68689290
18Basal transcription factors_Homo sapiens_hsa030221.68331799
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64833397
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63044038
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58415870
22Mismatch repair_Homo sapiens_hsa034301.58223366
23Fanconi anemia pathway_Homo sapiens_hsa034601.56354216
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55874768
25Tryptophan metabolism_Homo sapiens_hsa003801.52048136
26Regulation of autophagy_Homo sapiens_hsa041401.51612915
27RNA degradation_Homo sapiens_hsa030181.43693459
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.43612176
29Retinol metabolism_Homo sapiens_hsa008301.41272564
30Butanoate metabolism_Homo sapiens_hsa006501.40825741
31Alzheimers disease_Homo sapiens_hsa050101.38181906
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34557798
33Cardiac muscle contraction_Homo sapiens_hsa042601.33544286
34Allograft rejection_Homo sapiens_hsa053301.31006741
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29838378
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24231151
37Purine metabolism_Homo sapiens_hsa002301.23166777
38Ether lipid metabolism_Homo sapiens_hsa005651.21959924
39Pyrimidine metabolism_Homo sapiens_hsa002401.20441824
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17848110
41Circadian rhythm_Homo sapiens_hsa047101.17757701
42Arachidonic acid metabolism_Homo sapiens_hsa005901.16424874
43Autoimmune thyroid disease_Homo sapiens_hsa053201.15677178
44Nucleotide excision repair_Homo sapiens_hsa034201.12631600
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10548907
46Type I diabetes mellitus_Homo sapiens_hsa049401.09881036
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07680103
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04956287
49Nicotine addiction_Homo sapiens_hsa050331.03599327
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02390831
51Propanoate metabolism_Homo sapiens_hsa006401.00550617
52Primary immunodeficiency_Homo sapiens_hsa053400.99655867
53RNA transport_Homo sapiens_hsa030130.99602153
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98788734
55DNA replication_Homo sapiens_hsa030300.95507781
56Base excision repair_Homo sapiens_hsa034100.95288923
57Steroid biosynthesis_Homo sapiens_hsa001000.92290199
58beta-Alanine metabolism_Homo sapiens_hsa004100.91586666
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90232519
60Caffeine metabolism_Homo sapiens_hsa002320.87430135
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84458827
62Olfactory transduction_Homo sapiens_hsa047400.84203615
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83758000
64Chemical carcinogenesis_Homo sapiens_hsa052040.83602012
65Glycerolipid metabolism_Homo sapiens_hsa005610.82807120
66Metabolic pathways_Homo sapiens_hsa011000.81166098
67Non-homologous end-joining_Homo sapiens_hsa034500.80919453
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.80546889
69Rheumatoid arthritis_Homo sapiens_hsa053230.79920804
70Glutathione metabolism_Homo sapiens_hsa004800.77834178
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.76569186
72Ribosome_Homo sapiens_hsa030100.75818031
73Morphine addiction_Homo sapiens_hsa050320.74299557
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71102648
75Taste transduction_Homo sapiens_hsa047420.69893942
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69314747
77Salivary secretion_Homo sapiens_hsa049700.69276026
78Sulfur metabolism_Homo sapiens_hsa009200.67936421
79Peroxisome_Homo sapiens_hsa041460.67193408
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64288755
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62682556
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61530168
83Graft-versus-host disease_Homo sapiens_hsa053320.58936794
84Vitamin digestion and absorption_Homo sapiens_hsa049770.56754916
85Serotonergic synapse_Homo sapiens_hsa047260.56544313
86Histidine metabolism_Homo sapiens_hsa003400.54529151
87Collecting duct acid secretion_Homo sapiens_hsa049660.54058579
88Fat digestion and absorption_Homo sapiens_hsa049750.53616757
89Circadian entrainment_Homo sapiens_hsa047130.52279760
90Hematopoietic cell lineage_Homo sapiens_hsa046400.52110971
91Vitamin B6 metabolism_Homo sapiens_hsa007500.49052778
92Pyruvate metabolism_Homo sapiens_hsa006200.44401523
93PPAR signaling pathway_Homo sapiens_hsa033200.44362851
94Systemic lupus erythematosus_Homo sapiens_hsa053220.39981130
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39287695
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38571169
97Fatty acid biosynthesis_Homo sapiens_hsa000610.37940373
98Spliceosome_Homo sapiens_hsa030400.37095236
99Ovarian steroidogenesis_Homo sapiens_hsa049130.36832109
100GABAergic synapse_Homo sapiens_hsa047270.34596893

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