FABP5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.74217153
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.85461119
3proteasome assembly (GO:0043248)5.52053697
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.24378186
5somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.80875755
6isotype switching (GO:0045190)4.80875755
7somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.80875755
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.79445276
9regulation of mitotic spindle checkpoint (GO:1903504)4.79445276
10rRNA modification (GO:0000154)4.49460545
11water-soluble vitamin biosynthetic process (GO:0042364)4.48114345
12cytidine metabolic process (GO:0046087)4.33933494
13cytidine catabolic process (GO:0006216)4.33933494
14cytidine deamination (GO:0009972)4.33933494
15cullin deneddylation (GO:0010388)4.23360177
16regulation of immunoglobulin secretion (GO:0051023)4.15083789
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.00680307
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.00680307
19ribosomal small subunit assembly (GO:0000028)3.95209002
20protein deneddylation (GO:0000338)3.84738590
21platelet dense granule organization (GO:0060155)3.82685915
22pseudouridine synthesis (GO:0001522)3.73362684
23chaperone-mediated protein transport (GO:0072321)3.72222456
24protein neddylation (GO:0045116)3.71941544
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69681578
26negative regulation of transcription regulatory region DNA binding (GO:2000678)3.67432661
27protein targeting to mitochondrion (GO:0006626)3.63184803
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.62739601
29ATP synthesis coupled proton transport (GO:0015986)3.62739601
30mannosylation (GO:0097502)3.54114107
31somatic diversification of immunoglobulins (GO:0016445)3.50711137
32ribosome biogenesis (GO:0042254)3.46258513
33rRNA methylation (GO:0031167)3.45180708
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.41736616
35tongue development (GO:0043586)3.39179384
36pyrimidine ribonucleoside catabolic process (GO:0046133)3.37697919
37DNA damage induced protein phosphorylation (GO:0006975)3.35401605
38establishment of protein localization to mitochondrion (GO:0072655)3.34487930
39somatic recombination of immunoglobulin gene segments (GO:0016447)3.33449197
40regulation of mitochondrial translation (GO:0070129)3.31047506
41maturation of 5.8S rRNA (GO:0000460)3.27676085
42regulation of cellular amino acid metabolic process (GO:0006521)3.26771005
43GTP biosynthetic process (GO:0006183)3.25334587
44protein localization to mitochondrion (GO:0070585)3.25161677
45radial glial cell differentiation (GO:0060019)3.24371384
46protein complex biogenesis (GO:0070271)3.22215022
47DNA damage response, detection of DNA damage (GO:0042769)3.20448999
48transcription elongation from RNA polymerase I promoter (GO:0006362)3.20181062
49peptidyl-cysteine modification (GO:0018198)3.17207513
50negative regulation of calcium ion transport into cytosol (GO:0010523)3.15626418
51DNA double-strand break processing (GO:0000729)3.12467029
52outer ear morphogenesis (GO:0042473)3.11680155
53response to nitrosative stress (GO:0051409)3.07302833
54respiratory electron transport chain (GO:0022904)3.03951441
55electron transport chain (GO:0022900)3.02686185
56cellular component biogenesis (GO:0044085)3.01373291
57termination of RNA polymerase I transcription (GO:0006363)3.00073276
58positive regulation of endothelial cell apoptotic process (GO:2000353)3.00027000
59regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.98584172
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98098162
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96498791
62ribonucleoprotein complex biogenesis (GO:0022613)2.95469797
63negative regulation of heart rate (GO:0010459)2.93555493
64mitochondrial respiratory chain complex assembly (GO:0033108)2.92193812
65piRNA metabolic process (GO:0034587)2.91813076
66tRNA processing (GO:0008033)2.90213806
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88541193
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88219668
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88219668
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88219668
71regulation of spindle checkpoint (GO:0090231)2.87319478
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86728045
73ribosomal large subunit biogenesis (GO:0042273)2.86351318
74maturation of SSU-rRNA (GO:0030490)2.83497574
75neuron fate determination (GO:0048664)2.83284938
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81631613
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80967569
78mitochondrial respiratory chain complex I assembly (GO:0032981)2.80967569
79NADH dehydrogenase complex assembly (GO:0010257)2.80967569
80regulation of cofactor metabolic process (GO:0051193)2.80020692
81regulation of coenzyme metabolic process (GO:0051196)2.80020692
82intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79439189
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79439189
84inner mitochondrial membrane organization (GO:0007007)2.79133226
85protein maturation by protein folding (GO:0022417)2.75848684
86oxidative phosphorylation (GO:0006119)2.75770077
87UTP biosynthetic process (GO:0006228)2.75346511
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75315737
89branched-chain amino acid catabolic process (GO:0009083)2.75203224
90glyoxylate metabolic process (GO:0046487)2.75134852
91olfactory bulb development (GO:0021772)2.72326046
92cellular ketone body metabolic process (GO:0046950)2.72306247
93intracellular protein transmembrane import (GO:0044743)2.69864680
94negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.69566009
95tachykinin receptor signaling pathway (GO:0007217)2.68793497
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.68695468
97signal transduction involved in DNA integrity checkpoint (GO:0072401)2.68645267
98signal transduction involved in DNA damage checkpoint (GO:0072422)2.68645267
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65792734
100positive regulation of T cell migration (GO:2000406)2.65064406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.09840412
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.69671117
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19744544
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.32341996
5VDR_22108803_ChIP-Seq_LS180_Human3.18648503
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.11244978
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77149723
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77105971
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.74148055
10ZNF274_21170338_ChIP-Seq_K562_Hela2.27338590
11ELK1_19687146_ChIP-ChIP_HELA_Human2.26489257
12EZH2_22144423_ChIP-Seq_EOC_Human2.24851445
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19946573
14VDR_23849224_ChIP-Seq_CD4+_Human2.14873903
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11625473
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08513588
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.08023345
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.97375771
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96279052
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95299729
21EWS_26573619_Chip-Seq_HEK293_Human1.93723648
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90498468
23IRF1_19129219_ChIP-ChIP_H3396_Human1.78950192
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78426295
25FUS_26573619_Chip-Seq_HEK293_Human1.77690470
26TP53_22573176_ChIP-Seq_HFKS_Human1.75432303
27FOXP3_21729870_ChIP-Seq_TREG_Human1.75366667
28MYC_18940864_ChIP-ChIP_HL60_Human1.73002519
29DCP1A_22483619_ChIP-Seq_HELA_Human1.68637621
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.66251318
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.62064413
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58692251
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58185115
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56182481
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55219610
36GABP_19822575_ChIP-Seq_HepG2_Human1.52973237
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.52664901
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47446739
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46704124
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.45207109
41BCAT_22108803_ChIP-Seq_LS180_Human1.41587092
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40620644
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37724489
44ERG_20517297_ChIP-Seq_VCAP_Human1.36404950
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31391312
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28105744
47P300_19829295_ChIP-Seq_ESCs_Human1.27941951
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27820370
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27534018
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25285724
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24939764
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23812386
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22161831
54CBP_20019798_ChIP-Seq_JUKART_Human1.22161831
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20549403
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19572619
57IGF1R_20145208_ChIP-Seq_DFB_Human1.18786097
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16514223
59TTF2_22483619_ChIP-Seq_HELA_Human1.15668868
60NCOR_22424771_ChIP-Seq_293T_Human1.12676887
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12185814
62KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11905895
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11716610
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11357351
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10437315
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08805696
67HTT_18923047_ChIP-ChIP_STHdh_Human1.07946808
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07505995
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06714245
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.06216724
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.05894881
72MYC_19030024_ChIP-ChIP_MESCs_Mouse1.05855977
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.05145907
74TCF4_22108803_ChIP-Seq_LS180_Human1.04781381
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03922094
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.03580736
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.03441154
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02584518
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02358107
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01714668
81MYC_19829295_ChIP-Seq_ESCs_Human1.01223966
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99952465
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.99952465
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99565762
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.97912909
86GBX2_23144817_ChIP-Seq_PC3_Human0.96433977
87KDM5A_27292631_Chip-Seq_BREAST_Human0.96173984
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95120413
89AR_20517297_ChIP-Seq_VCAP_Human0.94931177
90NANOG_19829295_ChIP-Seq_ESCs_Human0.94618035
91SOX2_19829295_ChIP-Seq_ESCs_Human0.94618035
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93331719
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89005878
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88574507
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.87349860
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86688674
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.86170328
98TAF15_26573619_Chip-Seq_HEK293_Human0.85384815
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85217976
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84559829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.14181832
2MP0008789_abnormal_olfactory_epithelium4.54703312
3MP0005394_taste/olfaction_phenotype4.24630768
4MP0005499_abnormal_olfactory_system4.24630768
5MP0003136_yellow_coat_color3.06855479
6MP0006276_abnormal_autonomic_nervous2.74931923
7MP0000566_synostosis2.61267534
8MP0005645_abnormal_hypothalamus_physiol2.59527457
9MP0005408_hypopigmentation2.57161930
10MP0002102_abnormal_ear_morphology2.50545993
11MP0001529_abnormal_vocalization2.34664924
12MP0003693_abnormal_embryo_hatching2.30351465
13MP0003195_calcinosis2.16442119
14MP0003890_abnormal_embryonic-extraembry2.00053571
15MP0002234_abnormal_pharynx_morphology1.97689674
16MP0003880_abnormal_central_pattern1.88250936
17MP0008877_abnormal_DNA_methylation1.87758553
18MP0002938_white_spotting1.86632855
19MP0003011_delayed_dark_adaptation1.71259654
20MP0002736_abnormal_nociception_after1.70190256
21MP0000372_irregular_coat_pigmentation1.67856580
22MP0000604_amyloidosis1.61479945
23MP0002233_abnormal_nose_morphology1.59345015
24MP0005551_abnormal_eye_electrophysiolog1.56050641
25MP0005085_abnormal_gallbladder_physiolo1.49740116
26MP0009053_abnormal_anal_canal1.46522752
27MP0003315_abnormal_perineum_morphology1.46240026
28MP0002254_reproductive_system_inflammat1.46226539
29MP0008995_early_reproductive_senescence1.44286455
30MP0006035_abnormal_mitochondrial_morpho1.37188683
31MP0002095_abnormal_skin_pigmentation1.36203383
32MP0010030_abnormal_orbit_morphology1.34198886
33MP0002653_abnormal_ependyma_morphology1.33017799
34MP0004133_heterotaxia1.31337932
35MP0003718_maternal_effect1.30398267
36MP0000049_abnormal_middle_ear1.30168737
37MP0003122_maternal_imprinting1.29464857
38MP0001968_abnormal_touch/_nociception1.28939570
39MP0003329_amyloid_beta_deposits1.28165388
40MP0000631_abnormal_neuroendocrine_gland1.27948001
41MP0001986_abnormal_taste_sensitivity1.27442870
42MP0006036_abnormal_mitochondrial_physio1.27286257
43MP0008875_abnormal_xenobiotic_pharmacok1.25376823
44MP0001293_anophthalmia1.24048124
45MP0006072_abnormal_retinal_apoptosis1.22217801
46MP0002277_abnormal_respiratory_mucosa1.21749243
47MP0000427_abnormal_hair_cycle1.21552502
48MP0008872_abnormal_physiological_respon1.18724835
49MP0004147_increased_porphyrin_level1.17262470
50MP0004142_abnormal_muscle_tone1.16122869
51MP0004957_abnormal_blastocyst_morpholog1.15041694
52MP0002160_abnormal_reproductive_system1.14259729
53MP0005671_abnormal_response_to1.12490776
54MP0005379_endocrine/exocrine_gland_phen1.10794125
55MP0005410_abnormal_fertilization1.08598186
56MP0000778_abnormal_nervous_system1.08062767
57MP0005075_abnormal_melanosome_morpholog1.06826871
58MP0008058_abnormal_DNA_repair1.05549325
59MP0001984_abnormal_olfaction1.03542896
60MP0002272_abnormal_nervous_system1.03022679
61MP0002184_abnormal_innervation0.99979546
62MP0000639_abnormal_adrenal_gland0.99624057
63MP0002210_abnormal_sex_determination0.96720319
64MP0002163_abnormal_gland_morphology0.95480720
65MP0005195_abnormal_posterior_eye0.95202256
66MP0002752_abnormal_somatic_nervous0.94519877
67MP0005174_abnormal_tail_pigmentation0.93473417
68MP0009379_abnormal_foot_pigmentation0.92481277
69MP0001929_abnormal_gametogenesis0.91659748
70MP0008932_abnormal_embryonic_tissue0.91461352
71MP0004215_abnormal_myocardial_fiber0.91402943
72MP0002751_abnormal_autonomic_nervous0.89478778
73MP0000685_abnormal_immune_system0.88855172
74MP0002638_abnormal_pupillary_reflex0.82825735
75MP0002229_neurodegeneration0.81702572
76MP0005389_reproductive_system_phenotype0.81251921
77MP0002733_abnormal_thermal_nociception0.78240219
78MP0003121_genomic_imprinting0.76736661
79MP0005395_other_phenotype0.75953767
80MP0001905_abnormal_dopamine_level0.73956718
81MP0003937_abnormal_limbs/digits/tail_de0.72661838
82MP0004145_abnormal_muscle_electrophysio0.72601770
83MP0002249_abnormal_larynx_morphology0.72383479
84MP0005253_abnormal_eye_physiology0.71986371
85MP0003252_abnormal_bile_duct0.71350740
86MP0000647_abnormal_sebaceous_gland0.71205590
87MP0000026_abnormal_inner_ear0.70537290
88MP0001485_abnormal_pinna_reflex0.70324059
89MP0003698_abnormal_male_reproductive0.69622449
90MP0001970_abnormal_pain_threshold0.69539929
91MP0005646_abnormal_pituitary_gland0.69339317
92MP0010329_abnormal_lipoprotein_level0.67967098
93MP0003632_abnormal_nervous_system0.67862696
94MP0002006_tumorigenesis0.67503704
95MP0000653_abnormal_sex_gland0.67477359
96MP0005636_abnormal_mineral_homeostasis0.66639566
97MP0001145_abnormal_male_reproductive0.65597025
98MP0004019_abnormal_vitamin_homeostasis0.64480421
99MP0001963_abnormal_hearing_physiology0.64394616
100MP0009250_abnormal_appendicular_skeleto0.64229747

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)6.60577092
2Stomatitis (HP:0010280)6.44219499
3Abnormality of alanine metabolism (HP:0010916)3.85618663
4Hyperalaninemia (HP:0003348)3.85618663
5Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.85618663
6Multiple enchondromatosis (HP:0005701)3.44026924
73-Methylglutaconic aciduria (HP:0003535)3.37322614
8Abnormality of incisor morphology (HP:0011063)3.37068132
9Aplasia/Hypoplasia of the tongue (HP:0010295)3.32518381
10Medial flaring of the eyebrow (HP:0010747)3.20771893
11Nephronophthisis (HP:0000090)3.08431596
12Acute necrotizing encephalopathy (HP:0006965)2.98194553
13Mitochondrial inheritance (HP:0001427)2.96232169
14Increased CSF lactate (HP:0002490)2.90013990
15IgG deficiency (HP:0004315)2.84636632
16Abnormal hair whorl (HP:0010721)2.82760229
17Increased hepatocellular lipid droplets (HP:0006565)2.80557887
18Hepatocellular necrosis (HP:0001404)2.77240030
19Lipid accumulation in hepatocytes (HP:0006561)2.77097538
20Abnormal mitochondria in muscle tissue (HP:0008316)2.69890887
21Hypoplasia of the fovea (HP:0007750)2.66290362
22Aplasia/Hypoplasia of the fovea (HP:0008060)2.66290362
23Molar tooth sign on MRI (HP:0002419)2.64830986
24Abnormality of midbrain morphology (HP:0002418)2.64830986
25Pancreatic cysts (HP:0001737)2.60274273
26Abnormality of the aortic arch (HP:0012303)2.56587019
27Aplastic anemia (HP:0001915)2.55491165
28IgA deficiency (HP:0002720)2.52926080
29Congenital stationary night blindness (HP:0007642)2.52243103
30Intestinal atresia (HP:0011100)2.50334261
31Acute encephalopathy (HP:0006846)2.48016209
32Sensorimotor neuropathy (HP:0007141)2.46439171
33Abnormal drinking behavior (HP:0030082)2.45734980
34Polydipsia (HP:0001959)2.45734980
35Hepatic necrosis (HP:0002605)2.45398108
36True hermaphroditism (HP:0010459)2.44597931
37Respiratory difficulties (HP:0002880)2.43665103
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39452934
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39452934
40Abnormality of the labia minora (HP:0012880)2.35521356
41Abnormality of the renal medulla (HP:0100957)2.35203920
42Retinal atrophy (HP:0001105)2.33804963
43Oligomenorrhea (HP:0000876)2.31415840
44Increased serum pyruvate (HP:0003542)2.30169529
45Adrenal hypoplasia (HP:0000835)2.29776220
46Abnormality of the renal cortex (HP:0011035)2.28238977
47Chronic hepatic failure (HP:0100626)2.27655465
48Progressive macrocephaly (HP:0004481)2.27037421
49Enlarged kidneys (HP:0000105)2.26825923
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26745279
51Gait imbalance (HP:0002141)2.22796882
52Tubular atrophy (HP:0000092)2.21974754
53Rib fusion (HP:0000902)2.20600389
54Pancreatic fibrosis (HP:0100732)2.19686436
55Increased serum lactate (HP:0002151)2.18694662
56Abnormality of the metopic suture (HP:0005556)2.18333302
57Congenital primary aphakia (HP:0007707)2.13400546
58Microglossia (HP:0000171)2.11955736
59Reticulocytopenia (HP:0001896)2.11486632
60Limb dystonia (HP:0002451)2.11307453
61Abnormality of the fovea (HP:0000493)2.11096274
62Abnormality of the ileum (HP:0001549)2.09360345
63Meckel diverticulum (HP:0002245)2.06894028
64Abnormality of T cell physiology (HP:0011840)2.05491117
65Type 2 muscle fiber atrophy (HP:0003554)2.02225209
66Lactic acidosis (HP:0003128)2.00476732
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00339549
68Renal cortical cysts (HP:0000803)1.98378123
69Aplasia/hypoplasia of the uterus (HP:0008684)1.96453145
70Growth hormone deficiency (HP:0000824)1.95475122
71Abnormality of serum amino acid levels (HP:0003112)1.95215385
72Muscle fiber atrophy (HP:0100295)1.93437972
73Poor coordination (HP:0002370)1.93098802
74Sex reversal (HP:0012245)1.86334572
75Abnormal sex determination (HP:0012244)1.86334572
76Nephrogenic diabetes insipidus (HP:0009806)1.85322999
77Abnormality of the nasal septum (HP:0000419)1.83756118
78Male pseudohermaphroditism (HP:0000037)1.83169885
79Respiratory failure (HP:0002878)1.81204191
80Abnormality of the lower motor neuron (HP:0002366)1.81145417
81Hypergammaglobulinemia (HP:0010702)1.79640349
82Polyuria (HP:0000103)1.78182314
83Abnormality of glycolysis (HP:0004366)1.76841853
84Cerebral edema (HP:0002181)1.76625828
85Adactyly (HP:0009776)1.75080933
86Type II lissencephaly (HP:0007260)1.74574244
87Increased intramyocellular lipid droplets (HP:0012240)1.73743088
88Mesangial abnormality (HP:0001966)1.72620069
89Optic disc pallor (HP:0000543)1.72128159
90Absent thumb (HP:0009777)1.71287113
91Oligodactyly (HP:0012165)1.70406025
92Glycosuria (HP:0003076)1.68609785
93Abnormality of urine glucose concentration (HP:0011016)1.68609785
94Sclerocornea (HP:0000647)1.68184305
95Hypoplasia of the uterus (HP:0000013)1.67382111
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.66293622
97Neutropenia (HP:0001875)1.66201602
98Progressive inability to walk (HP:0002505)1.64211167
99Renal Fanconi syndrome (HP:0001994)1.64029273
100Abnormality of the vocal cords (HP:0008777)1.63772869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K26.17161027
2TRIM284.63518300
3ZAK4.49721389
4WNK42.59982399
5TSSK62.46511752
6PBK2.34215006
7SRPK12.28507844
8MKNK22.21795188
9NUAK12.21099330
10PDK22.18648342
11WNK32.16020313
12TLK12.02397979
13TESK21.98723102
14MST41.84609117
15GRK11.78050462
16BMPR1B1.78029879
17VRK21.68520086
18VRK11.67209795
19ADRBK21.51230809
20MKNK11.49281226
21BRSK21.44754096
22AKT31.43913557
23EPHB21.39916499
24STK391.37713596
25RPS6KA41.36414717
26DYRK21.27197465
27RPS6KA51.25342172
28EIF2AK11.23785551
29NME11.21373231
30PINK11.16270855
31BCR1.15531501
32TESK11.14633729
33KDR1.09599997
34FRK1.07681041
35PLK31.05186115
36LIMK11.03788981
37EIF2AK31.01236780
38ACVR1B0.95209225
39PHKG20.94073202
40PHKG10.94073202
41SGK4940.92072614
42SGK2230.92072614
43TGFBR10.85942055
44STK160.84878747
45WEE10.84171247
46OXSR10.83424824
47PAK30.82563279
48SGK20.81209263
49PIK3CA0.77743050
50BRSK10.73762528
51BUB10.72436150
52WNK10.71758536
53MAP3K120.70332012
54PTK2B0.70038144
55PRKCG0.68410923
56TIE10.65156721
57CSNK1G10.61283578
58DAPK10.60702299
59GRK50.60466868
60PRKCE0.57748067
61TNIK0.57441162
62CSNK1A10.56469009
63BCKDK0.54977808
64SCYL20.53787049
65TXK0.52966566
66PLK40.49816102
67EPHA40.49396815
68FGFR10.47921758
69PLK10.47669439
70EPHA30.47154982
71PNCK0.45929904
72TAOK20.45404181
73CSNK1G30.44113433
74NEK10.44095821
75ALK0.43553073
76IKBKB0.42463239
77PLK20.40503115
78CSNK1G20.40341503
79ADRBK10.40201966
80SIK30.39513945
81MAP3K80.38213550
82PIK3CG0.38043491
83CAMK2G0.38042438
84ATR0.36830218
85MINK10.36339010
86PRKD30.35966434
87IKBKE0.34392348
88RIPK40.33234245
89CHUK0.32816943
90PASK0.32706972
91CSNK1E0.32626649
92MAP2K60.31968639
93TTK0.31402768
94PRKCI0.31205770
95LATS10.30397258
96CSNK2A20.29888604
97STK30.29608393
98CAMK2A0.29448857
99CSNK2A10.27699104
100PRKG10.27589090

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.40492206
2Proteasome_Homo sapiens_hsa030503.96373960
3Oxidative phosphorylation_Homo sapiens_hsa001903.07853233
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03979293
5Parkinsons disease_Homo sapiens_hsa050122.80801627
6Protein export_Homo sapiens_hsa030602.53378010
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39096301
8Ribosome_Homo sapiens_hsa030102.36567984
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.29503600
10Basal transcription factors_Homo sapiens_hsa030222.26806227
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09090640
12Primary immunodeficiency_Homo sapiens_hsa053401.96567866
13Huntingtons disease_Homo sapiens_hsa050161.86951851
14RNA polymerase_Homo sapiens_hsa030201.84619945
15Phototransduction_Homo sapiens_hsa047441.82891121
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77937704
17Non-homologous end-joining_Homo sapiens_hsa034501.76147450
18Caffeine metabolism_Homo sapiens_hsa002321.67406832
19Alzheimers disease_Homo sapiens_hsa050101.62342916
20Sulfur metabolism_Homo sapiens_hsa009201.62333378
21RNA degradation_Homo sapiens_hsa030181.55008217
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49350082
23Propanoate metabolism_Homo sapiens_hsa006401.36074197
24Linoleic acid metabolism_Homo sapiens_hsa005911.35861160
25Cardiac muscle contraction_Homo sapiens_hsa042601.34049667
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24316069
27RNA transport_Homo sapiens_hsa030131.23756652
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22151207
29Fat digestion and absorption_Homo sapiens_hsa049751.22146487
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19283809
31Peroxisome_Homo sapiens_hsa041461.17449058
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16159502
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14593016
34Retinol metabolism_Homo sapiens_hsa008301.12192318
35Butanoate metabolism_Homo sapiens_hsa006501.10224324
36Steroid biosynthesis_Homo sapiens_hsa001001.09049092
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07966873
38Regulation of autophagy_Homo sapiens_hsa041401.06197278
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03002091
40Autoimmune thyroid disease_Homo sapiens_hsa053201.02181519
41Fatty acid degradation_Homo sapiens_hsa000711.01915404
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01132491
43Glutathione metabolism_Homo sapiens_hsa004800.96123756
44Nitrogen metabolism_Homo sapiens_hsa009100.93589275
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.93096379
46Allograft rejection_Homo sapiens_hsa053300.90015916
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89485970
48Homologous recombination_Homo sapiens_hsa034400.89011637
49Chemical carcinogenesis_Homo sapiens_hsa052040.88081894
50Pyruvate metabolism_Homo sapiens_hsa006200.84096085
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82880146
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81803688
53Selenocompound metabolism_Homo sapiens_hsa004500.80878177
54Asthma_Homo sapiens_hsa053100.79573664
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79573428
56Spliceosome_Homo sapiens_hsa030400.78039471
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.77746673
58Fatty acid metabolism_Homo sapiens_hsa012120.77246115
59Collecting duct acid secretion_Homo sapiens_hsa049660.75920678
60Metabolic pathways_Homo sapiens_hsa011000.75883015
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75789219
62Carbon metabolism_Homo sapiens_hsa012000.74121688
63Arachidonic acid metabolism_Homo sapiens_hsa005900.67814287
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.65527530
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64621042
66mRNA surveillance pathway_Homo sapiens_hsa030150.62358875
67Biosynthesis of amino acids_Homo sapiens_hsa012300.62082086
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61497210
69Nucleotide excision repair_Homo sapiens_hsa034200.61416115
70Purine metabolism_Homo sapiens_hsa002300.61269475
71Fanconi anemia pathway_Homo sapiens_hsa034600.61129290
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59107056
73Tryptophan metabolism_Homo sapiens_hsa003800.57783200
74PPAR signaling pathway_Homo sapiens_hsa033200.55699856
75Ether lipid metabolism_Homo sapiens_hsa005650.53306749
76Pyrimidine metabolism_Homo sapiens_hsa002400.52950572
77One carbon pool by folate_Homo sapiens_hsa006700.51390038
78Mismatch repair_Homo sapiens_hsa034300.50459530
79Hedgehog signaling pathway_Homo sapiens_hsa043400.47672588
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45540300
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.45509414
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44509859
83Vitamin digestion and absorption_Homo sapiens_hsa049770.43270684
84N-Glycan biosynthesis_Homo sapiens_hsa005100.42686718
85Base excision repair_Homo sapiens_hsa034100.41609614
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40810495
87Fatty acid elongation_Homo sapiens_hsa000620.39997986
88Olfactory transduction_Homo sapiens_hsa047400.39223711
89Circadian rhythm_Homo sapiens_hsa047100.38446165
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37919616
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37257572
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36093937
93Nicotine addiction_Homo sapiens_hsa050330.34972838
94TGF-beta signaling pathway_Homo sapiens_hsa043500.34631237
95Arginine and proline metabolism_Homo sapiens_hsa003300.34627955
96beta-Alanine metabolism_Homo sapiens_hsa004100.34585975
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.34515797
98Sphingolipid metabolism_Homo sapiens_hsa006000.34163378
99Arginine biosynthesis_Homo sapiens_hsa002200.32895930
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32408800

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