FABP5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.04329787
2cytidine deamination (GO:0009972)6.75747130
3cytidine metabolic process (GO:0046087)6.75747130
4cytidine catabolic process (GO:0006216)6.75747130
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.63521820
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.79444190
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98925320
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.84320114
9proteasome assembly (GO:0043248)4.76394558
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.53084645
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.45399643
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.44264170
13regulation of cellular amino acid metabolic process (GO:0006521)4.37240065
14intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.34312227
15signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.34312227
16signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.32745983
17signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.32745983
18signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.32745983
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.23515842
20ATP synthesis coupled proton transport (GO:0015986)4.23515842
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22301607
22chaperone-mediated protein transport (GO:0072321)4.13943491
23signal transduction involved in DNA damage checkpoint (GO:0072422)4.11778124
24signal transduction involved in DNA integrity checkpoint (GO:0072401)4.11778124
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.11146560
26respiratory electron transport chain (GO:0022904)4.09577937
27negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.09181521
28negative regulation of ligase activity (GO:0051352)4.09181521
29signal transduction involved in cell cycle checkpoint (GO:0072395)4.05706060
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.03405115
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.03405115
32deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.01911371
33electron transport chain (GO:0022900)4.01113255
34protein complex biogenesis (GO:0070271)3.98377020
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.96679591
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.92441403
37negative regulation of B cell apoptotic process (GO:0002903)3.80446570
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.78330570
39mitochondrial respiratory chain complex assembly (GO:0033108)3.75392695
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.73551661
41sequestering of actin monomers (GO:0042989)3.68754780
42antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.68377407
43purine deoxyribonucleotide catabolic process (GO:0009155)3.63512163
44telomere maintenance via semi-conservative replication (GO:0032201)3.60566883
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.58838148
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.58838148
47NADH dehydrogenase complex assembly (GO:0010257)3.58838148
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.55638568
49negative regulation by host of viral transcription (GO:0043922)3.48420571
50DNA double-strand break processing (GO:0000729)3.44441912
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41289231
52positive regulation of ligase activity (GO:0051351)3.39200767
53DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.38374896
54purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.35399123
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33740637
56positive regulation of cell cycle arrest (GO:0071158)3.33373453
57purine nucleotide salvage (GO:0032261)3.32667063
58deoxyribonucleotide catabolic process (GO:0009264)3.28272355
59deoxyribose phosphate catabolic process (GO:0046386)3.24367510
60telomere maintenance via recombination (GO:0000722)3.23801392
61regulation of cellular amine metabolic process (GO:0033238)3.16716865
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.12956009
63deoxyribose phosphate biosynthetic process (GO:0046385)3.12121013
642-deoxyribonucleotide biosynthetic process (GO:0009265)3.12121013
65oxidative phosphorylation (GO:0006119)3.10818836
66actin nucleation (GO:0045010)3.10027471
67regulation of ubiquitin-protein transferase activity (GO:0051438)3.08367381
68purine-containing compound salvage (GO:0043101)3.07918220
69mitotic recombination (GO:0006312)3.05843582
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.02587212
71platelet dense granule organization (GO:0060155)3.02471397
72DNA strand elongation involved in DNA replication (GO:0006271)3.02161436
73nucleotide-excision repair, DNA gap filling (GO:0006297)2.96769084
74regulation of ligase activity (GO:0051340)2.96596503
752-deoxyribonucleotide metabolic process (GO:0009394)2.96064101
76DNA ligation (GO:0006266)2.94804030
77negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.93327377
78negative regulation of cell cycle G1/S phase transition (GO:1902807)2.93327377
79regulation of mitochondrial translation (GO:0070129)2.93269407
80regulation of penile erection (GO:0060405)2.92250351
81purine deoxyribonucleotide metabolic process (GO:0009151)2.90764074
82mismatch repair (GO:0006298)2.90127057
83antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.89787968
84deoxyribose phosphate metabolic process (GO:0019692)2.89470455
85DNA strand elongation (GO:0022616)2.88169901
86metallo-sulfur cluster assembly (GO:0031163)2.87958694
87iron-sulfur cluster assembly (GO:0016226)2.87958694
88pyrimidine nucleoside catabolic process (GO:0046135)2.86049747
89signal transduction in response to DNA damage (GO:0042770)2.84406694
90protein neddylation (GO:0045116)2.82140850
91negative regulation of protein ubiquitination (GO:0031397)2.81934540
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.80912019
93termination of RNA polymerase III transcription (GO:0006386)2.80912019
94deoxyribonucleotide biosynthetic process (GO:0009263)2.80383220
95regulation of cell cycle arrest (GO:0071156)2.78541131
96telomere maintenance via telomere lengthening (GO:0010833)2.75929617
97deoxyribonucleotide metabolic process (GO:0009262)2.75844341
98protein targeting to mitochondrion (GO:0006626)2.72741372
99purine nucleobase biosynthetic process (GO:0009113)2.72737512
100DNA demethylation (GO:0080111)2.71844270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.12879361
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.97043399
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71415355
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.04298755
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.96209374
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.92662232
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.52150101
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33116678
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32589087
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81509881
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.81023435
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.77034105
13VDR_23849224_ChIP-Seq_CD4+_Human2.72745117
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72551031
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.72042946
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66711504
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65062755
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.52619156
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42563499
20FOXP3_21729870_ChIP-Seq_TREG_Human2.31554910
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30753645
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.29339494
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27604345
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24135002
25ELK1_19687146_ChIP-ChIP_HELA_Human2.22563321
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17760290
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15105400
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09637730
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99376662
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94464381
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86235823
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85209957
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84706808
34IGF1R_20145208_ChIP-Seq_DFB_Human1.82590836
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79246272
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67181830
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.65088948
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63152980
39DCP1A_22483619_ChIP-Seq_HELA_Human1.61499775
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60139325
41GABP_19822575_ChIP-Seq_HepG2_Human1.56237787
42IRF1_19129219_ChIP-ChIP_H3396_Human1.54032726
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51418670
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48079601
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43478673
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.41323002
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38987220
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36836412
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36641729
50TTF2_22483619_ChIP-Seq_HELA_Human1.36128074
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36088404
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34899834
53MYB_26560356_Chip-Seq_TH2_Human1.34383167
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33157052
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30968325
56SPI1_23547873_ChIP-Seq_NB4_Human1.24509519
57MYC_18940864_ChIP-ChIP_HL60_Human1.22178518
58CIITA_25753668_ChIP-Seq_RAJI_Human1.19522873
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17889433
60TP53_22573176_ChIP-Seq_HFKS_Human1.13438539
61GATA3_26560356_Chip-Seq_TH2_Human1.12066956
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10684064
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10659683
64ZNF274_21170338_ChIP-Seq_K562_Hela1.09651323
65XRN2_22483619_ChIP-Seq_HELA_Human1.07072298
66VDR_22108803_ChIP-Seq_LS180_Human1.06259710
67KDM5A_27292631_Chip-Seq_BREAST_Human1.04512291
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04454565
69HTT_18923047_ChIP-ChIP_STHdh_Human1.02134997
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00764548
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.00201723
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99708256
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98948786
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98473284
75ERG_20517297_ChIP-Seq_VCAP_Human0.98153653
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97963637
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97355782
78POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96603096
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96600400
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95979886
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95335397
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93134600
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92603952
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92061068
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90982831
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.89937850
87GATA3_27048872_Chip-Seq_THYMUS_Human0.88150468
88EWS_26573619_Chip-Seq_HEK293_Human0.87966795
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87125218
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87115641
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.87115641
92E2F1_21310950_ChIP-Seq_MCF-7_Human0.84895096
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84662155
94MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83065394
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.82754230
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82626993
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81871797
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77604996
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77422626
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77036461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.66655536
2MP0003806_abnormal_nucleotide_metabolis3.36191924
3MP0003136_yellow_coat_color3.31608867
4MP0009697_abnormal_copulation3.05441319
5MP0010094_abnormal_chromosome_stability2.85714933
6MP0008058_abnormal_DNA_repair2.75602593
7MP0004147_increased_porphyrin_level2.63526639
8MP0001835_abnormal_antigen_presentation2.55275335
9MP0005084_abnormal_gallbladder_morpholo2.54327879
10MP0003786_premature_aging2.34040521
11MP0000372_irregular_coat_pigmentation2.27641169
12MP0003763_abnormal_thymus_physiology2.22530034
13MP0002102_abnormal_ear_morphology2.18503070
14MP0002148_abnormal_hypersensitivity_rea2.17145442
15MP0002166_altered_tumor_susceptibility2.16065590
16MP0009785_altered_susceptibility_to2.06145315
17MP0006036_abnormal_mitochondrial_physio2.03776126
18MP0008877_abnormal_DNA_methylation1.99998049
19MP0002006_tumorigenesis1.98667641
20MP0009333_abnormal_splenocyte_physiolog1.79592659
21MP0004957_abnormal_blastocyst_morpholog1.69769012
22MP0006082_CNS_inflammation1.69299647
23MP0005171_absent_coat_pigmentation1.66288310
24MP0009379_abnormal_foot_pigmentation1.66065102
25MP0005645_abnormal_hypothalamus_physiol1.65444393
26MP0003693_abnormal_embryo_hatching1.62785346
27MP0003718_maternal_effect1.60659458
28MP0001800_abnormal_humoral_immune1.60586116
29MP0005000_abnormal_immune_tolerance1.59369657
30MP0005075_abnormal_melanosome_morpholog1.58069074
31MP0002420_abnormal_adaptive_immunity1.57838753
32MP0001764_abnormal_homeostasis1.56446346
33MP0008789_abnormal_olfactory_epithelium1.56367451
34MP0002396_abnormal_hematopoietic_system1.55966794
35MP0000685_abnormal_immune_system1.54928318
36MP0001905_abnormal_dopamine_level1.52209571
37MP0002398_abnormal_bone_marrow1.51493043
38MP0005025_abnormal_response_to1.50850281
39MP0001819_abnormal_immune_cell1.49545071
40MP0008007_abnormal_cellular_replicative1.48739451
41MP0006072_abnormal_retinal_apoptosis1.47108134
42MP0002723_abnormal_immune_serum1.41216420
43MP0001529_abnormal_vocalization1.38219761
44MP0000716_abnormal_immune_system1.37061942
45MP0002452_abnormal_antigen_presenting1.34514566
46MP0002822_catalepsy1.34467503
47MP0005387_immune_system_phenotype1.32880545
48MP0001790_abnormal_immune_system1.32880545
49MP0004145_abnormal_muscle_electrophysio1.31469496
50MP0002234_abnormal_pharynx_morphology1.30945024
51MP0002163_abnormal_gland_morphology1.30502016
52MP0003186_abnormal_redox_activity1.27655867
53MP0002019_abnormal_tumor_incidence1.27096238
54MP0008932_abnormal_embryonic_tissue1.26942773
55MP0003111_abnormal_nucleus_morphology1.25926581
56MP0003077_abnormal_cell_cycle1.25538195
57MP0008872_abnormal_physiological_respon1.24661525
58MP0000689_abnormal_spleen_morphology1.24391316
59MP0002653_abnormal_ependyma_morphology1.22871520
60MP0006035_abnormal_mitochondrial_morpho1.18838030
61MP0002722_abnormal_immune_system1.18437783
62MP0002429_abnormal_blood_cell1.17917337
63MP0008873_increased_physiological_sensi1.14528081
64MP0008057_abnormal_DNA_replication1.14143341
65MP0008875_abnormal_xenobiotic_pharmacok1.13023241
66MP0005379_endocrine/exocrine_gland_phen1.12623231
67MP0003011_delayed_dark_adaptation1.10048221
68MP0001968_abnormal_touch/_nociception1.06155617
69MP0002095_abnormal_skin_pigmentation1.05023550
70MP0002405_respiratory_system_inflammati1.04407959
71MP0001853_heart_inflammation1.02199166
72MP0006292_abnormal_olfactory_placode0.99739494
73MP0002277_abnormal_respiratory_mucosa0.98013369
74MP0005389_reproductive_system_phenotype0.94174416
75MP0001485_abnormal_pinna_reflex0.94025170
76MP0000703_abnormal_thymus_morphology0.92992329
77MP0001919_abnormal_reproductive_system0.91710000
78MP0003866_abnormal_defecation0.91563135
79MP0005253_abnormal_eye_physiology0.91534859
80MP0005174_abnormal_tail_pigmentation0.90568945
81MP0009764_decreased_sensitivity_to0.89096778
82MP0002419_abnormal_innate_immunity0.88143424
83MP0002876_abnormal_thyroid_physiology0.87736083
84MP0000358_abnormal_cell_content/0.85264851
85MP0008995_early_reproductive_senescence0.84641608
86MP0000465_gastrointestinal_hemorrhage0.84623826
87MP0000490_abnormal_crypts_of0.82720199
88MP0001873_stomach_inflammation0.80288330
89MP0001845_abnormal_inflammatory_respons0.79221489
90MP0003252_abnormal_bile_duct0.78750977
91MP0004142_abnormal_muscle_tone0.78101275
92MP0002837_dystrophic_cardiac_calcinosis0.77673008
93MP0005266_abnormal_metabolism0.74730820
94MP0009763_increased_sensitivity_to0.73689181
95MP0008469_abnormal_protein_level0.73143163
96MP0001119_abnormal_female_reproductive0.72508691
97MP0005464_abnormal_platelet_physiology0.72017271
98MP0005410_abnormal_fertilization0.69309944
99MP0005636_abnormal_mineral_homeostasis0.69295427
100MP0010386_abnormal_urinary_bladder0.67782999

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.86724540
2Mitochondrial inheritance (HP:0001427)4.80440394
3Abnormal mitochondria in muscle tissue (HP:0008316)4.67166726
4Hepatocellular necrosis (HP:0001404)4.22931723
5Acute encephalopathy (HP:0006846)4.19106971
6Increased hepatocellular lipid droplets (HP:0006565)4.15889333
7Increased CSF lactate (HP:0002490)4.13134558
8Lipid accumulation in hepatocytes (HP:0006561)4.02379514
9Progressive macrocephaly (HP:0004481)3.98801139
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.98168723
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.98168723
12Abnormality of B cell number (HP:0010975)3.98163203
13Aplastic anemia (HP:0001915)3.82154239
14Hepatic necrosis (HP:0002605)3.80965633
15B lymphocytopenia (HP:0010976)3.79207507
16Increased intramyocellular lipid droplets (HP:0012240)3.75966450
17Severe combined immunodeficiency (HP:0004430)3.64095678
18Autoimmune hemolytic anemia (HP:0001890)3.45918102
19Increased IgM level (HP:0003496)3.45224837
20Renal Fanconi syndrome (HP:0001994)3.39209272
21Increased muscle lipid content (HP:0009058)3.37315692
22Cerebral edema (HP:0002181)3.23882788
23Autoimmune thrombocytopenia (HP:0001973)3.15465523
24Combined immunodeficiency (HP:0005387)3.09096024
25Agammaglobulinemia (HP:0004432)3.00674170
26Exertional dyspnea (HP:0002875)3.00227819
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.91930198
28IgG deficiency (HP:0004315)2.91428522
29Type I transferrin isoform profile (HP:0003642)2.87361292
303-Methylglutaconic aciduria (HP:0003535)2.84081276
31Abnormality of the prostate (HP:0008775)2.83207622
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.77783426
33Eosinophilia (HP:0001880)2.75694159
34Increased serum lactate (HP:0002151)2.74063461
35Lactic acidosis (HP:0003128)2.73904392
36Respiratory failure (HP:0002878)2.73285014
37Hypoproteinemia (HP:0003075)2.63047727
38Multiple enchondromatosis (HP:0005701)2.62418260
39Amyotrophic lateral sclerosis (HP:0007354)2.61762942
40Exercise intolerance (HP:0003546)2.60588864
41Thyroiditis (HP:0100646)2.59130884
42Elevated erythrocyte sedimentation rate (HP:0003565)2.54451957
43Dicarboxylic aciduria (HP:0003215)2.51736819
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51736819
45Abnormality of T cell number (HP:0011839)2.51018387
46Cerebral palsy (HP:0100021)2.49833352
47Optic disc pallor (HP:0000543)2.49156578
48Obstructive lung disease (HP:0006536)2.48327809
49Chronic obstructive pulmonary disease (HP:0006510)2.48327809
50Granulocytopenia (HP:0001913)2.44417995
51Abnormality of eosinophils (HP:0001879)2.43623083
52Pancytopenia (HP:0001876)2.40815673
53Abnormality of T cells (HP:0002843)2.38617243
54Generalized aminoaciduria (HP:0002909)2.34588818
55Oral leukoplakia (HP:0002745)2.32691479
56Leukodystrophy (HP:0002415)2.31535196
57Respiratory difficulties (HP:0002880)2.30102005
58Panhypogammaglobulinemia (HP:0003139)2.25230435
59T lymphocytopenia (HP:0005403)2.21284306
60Progressive microcephaly (HP:0000253)2.19688451
61CNS demyelination (HP:0007305)2.16141950
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15442017
63Abnormal protein N-linked glycosylation (HP:0012347)2.15442017
64Abnormal protein glycosylation (HP:0012346)2.15442017
65Abnormal glycosylation (HP:0012345)2.15442017
66Reduced antithrombin III activity (HP:0001976)2.14951833
67IgM deficiency (HP:0002850)2.09830692
68Colon cancer (HP:0003003)2.09340668
69Abnormality of T cell physiology (HP:0011840)2.08390896
70Neoplasm of the adrenal gland (HP:0100631)2.04622219
71Atrophy/Degeneration involving motor neurons (HP:0007373)2.04239095
72Abolished electroretinogram (ERG) (HP:0000550)2.01991657
73Lethargy (HP:0001254)2.01483632
74Mesangial abnormality (HP:0001966)1.96722291
75Hypergammaglobulinemia (HP:0010702)1.95796549
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95235810
77Meningitis (HP:0001287)1.94995262
78Microvesicular hepatic steatosis (HP:0001414)1.94682435
79Aplasia/Hypoplasia of the thymus (HP:0010515)1.89752522
80Neutropenia (HP:0001875)1.87985740
81Abnormality of urine glucose concentration (HP:0011016)1.87526034
82Glycosuria (HP:0003076)1.87526034
83Abnormality of renal resorption (HP:0011038)1.85644678
84Hyperglycinemia (HP:0002154)1.85553310
85Stomatitis (HP:0010280)1.84727969
86Meckel diverticulum (HP:0002245)1.84007095
87Recurrent viral infections (HP:0004429)1.83588485
88Spastic paraparesis (HP:0002313)1.83122687
89Abnormal delayed hypersensitivity skin test (HP:0002963)1.83032710
90Abnormality of male internal genitalia (HP:0000022)1.81667724
91Type 2 muscle fiber atrophy (HP:0003554)1.80316707
92Hyperphosphaturia (HP:0003109)1.77106293
93Amniotic constriction ring (HP:0009775)1.74322564
94Abnormality of placental membranes (HP:0011409)1.74322564
95Leukocytosis (HP:0001974)1.73745129
96Hypoplasia of the thymus (HP:0000778)1.71163152
97Abnormality of the ileum (HP:0001549)1.70537376
98Pulmonary fibrosis (HP:0002206)1.69833275
99Muscle fiber atrophy (HP:0100295)1.68854603
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.66321222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.49577010
2KDR4.79084166
3TESK23.47261641
4NUAK12.97318443
5VRK12.76020415
6SCYL22.47704856
7TESK12.22907562
8BUB12.19455515
9TXK2.06860488
10MST42.06647518
11EIF2AK32.05052299
12MAP4K22.03211329
13BCKDK1.94781509
14NEK11.93252128
15MAP3K121.91869668
16WEE11.85226162
17SRPK11.77537913
18KIT1.74538912
19LIMK11.66674506
20ZAK1.65777160
21TIE11.50541726
22NME21.48978843
23STK161.46992337
24BMPR21.31457991
25PBK1.30807344
26CDC71.29902183
27TAOK31.27016192
28CDK81.17538092
29EIF2AK11.16182302
30TAF11.14468190
31FLT31.13258885
32TSSK61.10854258
33BMPR1B1.09123224
34ADRBK21.06478568
35DAPK11.06394949
36CCNB11.04196252
37MAP3K110.97820057
38MAPK150.95924392
39PLK40.92139609
40PLK30.88925196
41DYRK20.87708172
42EIF2AK20.87337755
43GRK10.87047818
44CSNK1G30.86897949
45STK390.86612440
46MAP4K10.85397340
47SYK0.83634504
48PNCK0.82298464
49PIM20.82175994
50ATR0.78949814
51TNK20.78021808
52FES0.76668671
53OXSR10.74019026
54PLK10.73291897
55PRKCQ0.73181253
56ABL20.72182130
57CHEK20.70825945
58RPS6KA40.70810221
59AURKB0.70493112
60BCR0.70397779
61MAPKAPK50.69749407
62INSRR0.69539763
63CSNK1G10.68957733
64ITK0.67129318
65CASK0.66075126
66CSF1R0.64585092
67AURKA0.64270496
68CSNK1A1L0.61559784
69TEC0.59946318
70LYN0.59226015
71MAPKAPK30.58086077
72CSNK1G20.56806451
73GRK70.55765228
74GRK50.55618894
75PLK20.55457674
76STK38L0.55414353
77CSNK2A10.54796497
78NME10.52935296
79WNK40.51935165
80MAPK130.50808622
81LCK0.49934314
82WNK30.49453761
83MYLK0.49226254
84BRSK20.48332614
85MATK0.48241754
86RPS6KA50.47016238
87IKBKB0.46237371
88TLK10.44888875
89CSNK2A20.43379380
90BLK0.42892521
91CDK90.42252709
92DYRK30.41089635
93PDK20.33897039
94TTK0.31745082
95DAPK30.30803009
96MAP2K70.30170078
97CSNK1A10.29819090
98LRRK20.28508014
99BTK0.28186118
100MAPKAPK20.27356735

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.29343965
2Oxidative phosphorylation_Homo sapiens_hsa001903.46668842
3DNA replication_Homo sapiens_hsa030303.23757184
4Parkinsons disease_Homo sapiens_hsa050123.20773534
5Primary immunodeficiency_Homo sapiens_hsa053403.01476046
6Protein export_Homo sapiens_hsa030602.84973056
7Mismatch repair_Homo sapiens_hsa034302.60282228
8Homologous recombination_Homo sapiens_hsa034402.23638937
9Base excision repair_Homo sapiens_hsa034102.21065107
10RNA polymerase_Homo sapiens_hsa030202.17529136
11Graft-versus-host disease_Homo sapiens_hsa053322.12985599
12Asthma_Homo sapiens_hsa053102.05485746
13Allograft rejection_Homo sapiens_hsa053302.03434356
14Alzheimers disease_Homo sapiens_hsa050101.99703443
15Autoimmune thyroid disease_Homo sapiens_hsa053201.99236830
16Huntingtons disease_Homo sapiens_hsa050161.98117188
17Ribosome_Homo sapiens_hsa030101.90846432
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89070685
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83957005
20Antigen processing and presentation_Homo sapiens_hsa046121.82424334
21Nucleotide excision repair_Homo sapiens_hsa034201.80500673
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76197921
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74802894
24Fanconi anemia pathway_Homo sapiens_hsa034601.71497451
25Non-homologous end-joining_Homo sapiens_hsa034501.69410770
26Pyrimidine metabolism_Homo sapiens_hsa002401.66281114
27Type I diabetes mellitus_Homo sapiens_hsa049401.54924644
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.45553779
29Spliceosome_Homo sapiens_hsa030401.42521357
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38878585
31Propanoate metabolism_Homo sapiens_hsa006401.32198144
32One carbon pool by folate_Homo sapiens_hsa006701.31288401
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26133857
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22460656
35Rheumatoid arthritis_Homo sapiens_hsa053231.18607946
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16426280
37RNA degradation_Homo sapiens_hsa030181.14486772
38Cardiac muscle contraction_Homo sapiens_hsa042601.10876654
39Hematopoietic cell lineage_Homo sapiens_hsa046401.04676336
40Purine metabolism_Homo sapiens_hsa002301.02950031
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01135531
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99448094
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96320075
44Peroxisome_Homo sapiens_hsa041460.91730445
45Viral myocarditis_Homo sapiens_hsa054160.88611806
46RNA transport_Homo sapiens_hsa030130.88319281
47Basal transcription factors_Homo sapiens_hsa030220.84181749
48Pyruvate metabolism_Homo sapiens_hsa006200.80673433
49Butanoate metabolism_Homo sapiens_hsa006500.79440085
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75361382
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73089190
52Steroid biosynthesis_Homo sapiens_hsa001000.72807943
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.72227029
54Glutathione metabolism_Homo sapiens_hsa004800.72061371
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70679140
56Folate biosynthesis_Homo sapiens_hsa007900.69643774
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61543439
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61143516
59Sulfur relay system_Homo sapiens_hsa041220.60859647
60Carbon metabolism_Homo sapiens_hsa012000.60433861
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60421281
62Sulfur metabolism_Homo sapiens_hsa009200.59373025
63Metabolic pathways_Homo sapiens_hsa011000.58019198
64Fatty acid elongation_Homo sapiens_hsa000620.57992362
65Epstein-Barr virus infection_Homo sapiens_hsa051690.57990608
66Shigellosis_Homo sapiens_hsa051310.57930855
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.57799415
68Salmonella infection_Homo sapiens_hsa051320.55713922
69Systemic lupus erythematosus_Homo sapiens_hsa053220.53214134
70Caffeine metabolism_Homo sapiens_hsa002320.49927060
71Cell cycle_Homo sapiens_hsa041100.47724722
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47186311
73Fatty acid degradation_Homo sapiens_hsa000710.46724387
74Herpes simplex infection_Homo sapiens_hsa051680.42868456
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41871329
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40934810
77Staphylococcus aureus infection_Homo sapiens_hsa051500.40522635
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.38590006
79Phototransduction_Homo sapiens_hsa047440.38061675
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.36372140
81Fatty acid metabolism_Homo sapiens_hsa012120.36175650
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34496533
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.33936777
84mRNA surveillance pathway_Homo sapiens_hsa030150.33438590
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31505024
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30921340
87Olfactory transduction_Homo sapiens_hsa047400.30863112
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29246258
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26340345
90Measles_Homo sapiens_hsa051620.26183180
91p53 signaling pathway_Homo sapiens_hsa041150.26165585
92Collecting duct acid secretion_Homo sapiens_hsa049660.25781150
93Leishmaniasis_Homo sapiens_hsa051400.25448703
94Tryptophan metabolism_Homo sapiens_hsa003800.25169248
95Chemical carcinogenesis_Homo sapiens_hsa052040.24298263
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24166577
97N-Glycan biosynthesis_Homo sapiens_hsa005100.23947448
98Retinol metabolism_Homo sapiens_hsa008300.21926344
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20074699
100Legionellosis_Homo sapiens_hsa051340.19072752

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