FABP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of visible light (GO:0009584)9.72349913
2detection of light stimulus (GO:0009583)9.68194389
3regulation of guanylate cyclase activity (GO:0031282)9.41930648
4GMP metabolic process (GO:0046037)9.30410752
5protein-chromophore linkage (GO:0018298)9.17589314
6retinal rod cell development (GO:0046548)8.44367674
7visual perception (GO:0007601)8.33829921
8sensory perception of light stimulus (GO:0050953)8.24156727
9cellular response to light stimulus (GO:0071482)7.13062379
10photoreceptor cell differentiation (GO:0046530)6.86054958
11eye photoreceptor cell differentiation (GO:0001754)6.86054958
12detection of external stimulus (GO:0009581)6.77616180
13regulation of cGMP metabolic process (GO:0030823)6.66321993
14detection of abiotic stimulus (GO:0009582)6.64127470
15retina development in camera-type eye (GO:0060041)6.30350520
16positive regulation of cGMP biosynthetic process (GO:0030828)6.29314606
17regulation of cGMP biosynthetic process (GO:0030826)5.93245971
18detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.70990265
19positive regulation of cGMP metabolic process (GO:0030825)5.52063592
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.23286525
21receptor guanylyl cyclase signaling pathway (GO:0007168)4.87734557
22nonmotile primary cilium assembly (GO:0035058)4.81945621
23cellular response to radiation (GO:0071478)4.57529363
24positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.45697454
25cell morphogenesis involved in neuron differentiation (GO:0048667)4.31533811
26regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.16894524
27adaptation of signaling pathway (GO:0023058)4.13525190
28sensory perception (GO:0007600)3.89113656
29regulation of voltage-gated calcium channel activity (GO:1901385)3.83100810
30sperm motility (GO:0030317)3.80020926
31detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.76179348
32response to light stimulus (GO:0009416)3.71606885
33short-term memory (GO:0007614)3.69859669
34motile cilium assembly (GO:0044458)3.64539900
35prenylation (GO:0097354)3.64495464
36protein prenylation (GO:0018342)3.64495464
37cell wall macromolecule catabolic process (GO:0016998)3.51417195
38cell wall macromolecule metabolic process (GO:0044036)3.51417195
39detection of chemical stimulus involved in sensory perception (GO:0050907)3.50163688
40regulation of penile erection (GO:0060405)3.41325133
41retina layer formation (GO:0010842)3.39908044
42positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.37424779
43neuron development (GO:0048666)3.37202895
44CDP-diacylglycerol biosynthetic process (GO:0016024)3.34657794
45regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.33736012
46regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.33736012
47behavioral response to ethanol (GO:0048149)3.33063214
48estrogen biosynthetic process (GO:0006703)3.32197098
49protein localization to synapse (GO:0035418)3.24439971
50response to histamine (GO:0034776)3.20643590
51axoneme assembly (GO:0035082)3.18941905
52chemosensory behavior (GO:0007635)3.16443758
53retina homeostasis (GO:0001895)3.15261616
54regulation of cilium movement (GO:0003352)3.11774331
55CDP-diacylglycerol metabolic process (GO:0046341)3.07775874
56positive regulation of sodium ion transmembrane transport (GO:1902307)3.05326355
57regulation of clathrin-mediated endocytosis (GO:2000369)3.05148662
58positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.03498081
59acrosome reaction (GO:0007340)3.02634863
60fusion of sperm to egg plasma membrane (GO:0007342)3.00943834
61lipid translocation (GO:0034204)2.94188224
62phospholipid translocation (GO:0045332)2.94188224
63negative regulation of receptor-mediated endocytosis (GO:0048261)2.91046989
64acrosome assembly (GO:0001675)2.90644488
65membrane hyperpolarization (GO:0060081)2.90268049
66positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.85339053
67positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.85000482
68negative regulation of transcription regulatory region DNA binding (GO:2000678)2.84323908
69retinoid metabolic process (GO:0001523)2.81766457
70positive regulation of neurotransmitter transport (GO:0051590)2.79107209
71icosanoid secretion (GO:0032309)2.78988601
72arachidonic acid secretion (GO:0050482)2.78988601
73sperm-egg recognition (GO:0035036)2.77646521
74multicellular organism reproduction (GO:0032504)2.75139645
75epithelial cilium movement (GO:0003351)2.66809016
76positive regulation of ERBB signaling pathway (GO:1901186)2.64761234
77retinol metabolic process (GO:0042572)2.61439339
78diterpenoid metabolic process (GO:0016101)2.61172467
79response to radiation (GO:0009314)2.57765998
80positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.55813875
81lactate metabolic process (GO:0006089)2.55769185
82positive regulation of cyclase activity (GO:0031281)2.51684101
83peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.50834822
84spermatid development (GO:0007286)2.50371966
85plasma membrane fusion (GO:0045026)2.48570942
86positive regulation of lyase activity (GO:0051349)2.47201454
87behavioral response to cocaine (GO:0048148)2.46340707
88cell-cell recognition (GO:0009988)2.46149959
89binding of sperm to zona pellucida (GO:0007339)2.45026180
90regulation of rhodopsin mediated signaling pathway (GO:0022400)17.6004517
91rhodopsin mediated signaling pathway (GO:0016056)17.0639841
92retinal cone cell development (GO:0046549)15.7021359
93photoreceptor cell development (GO:0042461)11.8667682
94eye photoreceptor cell development (GO:0042462)11.4999547
95detection of light stimulus involved in sensory perception (GO:0050962)11.1586212
96detection of light stimulus involved in visual perception (GO:0050908)11.1586212
97photoreceptor cell maintenance (GO:0045494)11.1458233
98positive regulation of guanylate cyclase activity (GO:0031284)10.3811579
99phototransduction (GO:0007602)10.1288366
100phototransduction, visible light (GO:0007603)10.0471791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.12188062
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.48346838
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.47357475
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09531445
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.04882117
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67595632
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.04573104
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96122534
9GBX2_23144817_ChIP-Seq_PC3_Human1.85570400
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78974115
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78156472
12MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64330192
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62846071
14DROSHA_22980978_ChIP-Seq_HELA_Human1.61631901
15REST_21632747_ChIP-Seq_MESCs_Mouse1.61393452
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56430616
17NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.55746653
18WDR5_24793694_ChIP-Seq_LNCAP_Human1.51630423
19ELK4_26923725_Chip-Seq_MESODERM_Mouse1.49287667
20STAT1_17558387_ChIP-Seq_HELA_Human1.44259215
21TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.43591689
22MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.43141936
23SMAD3_21741376_ChIP-Seq_HESCs_Human1.41965346
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41683439
25CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36875856
26TBL1_22424771_ChIP-Seq_293T_Human1.34161143
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33267740
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.33117753
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33105698
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.32722509
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31979805
32TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29986589
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.29164818
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28551617
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.28384162
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27377825
37CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26895682
38GF1_26923725_Chip-Seq_HPCs_Mouse1.25962700
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.24482678
40BCAT_22108803_ChIP-Seq_LS180_Human1.22691106
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.21879083
42SMC4_20622854_ChIP-Seq_HELA_Human1.21296380
43TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19801446
44CBP_20019798_ChIP-Seq_JUKART_Human1.18711411
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18711411
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.17390152
47FLI1_21867929_ChIP-Seq_TH2_Mouse1.16861283
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.15495387
49CBP_21632823_ChIP-Seq_H3396_Human1.14772166
50* KDM2B_26808549_Chip-Seq_REH_Human1.14404870
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.14089600
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13779723
53SMAD4_21799915_ChIP-Seq_A2780_Human1.13482271
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.12366243
55CTCF_20526341_ChIP-Seq_ESCs_Human1.07958768
56* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07629076
57OCT1_27270436_Chip-Seq_PROSTATE_Human1.06443328
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04636626
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03591801
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03536148
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03482074
62LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.03461372
63NANOG_20526341_ChIP-Seq_ESCs_Human1.03336425
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03319085
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03293083
66* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03161392
67ERG_20517297_ChIP-Seq_VCAP_Human1.02628433
68P300_19829295_ChIP-Seq_ESCs_Human1.01866029
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01733727
70AR_19668381_ChIP-Seq_PC3_Human1.01625969
71NCOR_22424771_ChIP-Seq_293T_Human1.01524061
72CTCF_27219007_Chip-Seq_Bcells_Human1.01113310
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00683619
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00683619
75GF1B_26923725_Chip-Seq_HPCs_Mouse1.00168786
76IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99689680
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99637113
78NFE2_27457419_Chip-Seq_LIVER_Mouse0.99493480
79ZNF274_21170338_ChIP-Seq_K562_Hela0.99355184
80CMYC_18555785_Chip-Seq_ESCs_Mouse0.98640916
81* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96701689
82TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96628232
83HTT_18923047_ChIP-ChIP_STHdh_Human0.96627210
84RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96594639
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96171412
86STAT3_23295773_ChIP-Seq_U87_Human0.95243332
87* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93951352
88GATA3_21867929_ChIP-Seq_CD8_Mouse0.92370139
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92254925
90CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91743975
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91726264
92RARB_27405468_Chip-Seq_BRAIN_Mouse0.90502820
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90078979
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89820025
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89721324
96TCF4_23295773_ChIP-Seq_U87_Human0.89351590
97ER_23166858_ChIP-Seq_MCF-7_Human0.88921484
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88152662
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88092439
100CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87564205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.94846518
2MP0005253_abnormal_eye_physiology6.82727975
3MP0006072_abnormal_retinal_apoptosis6.35934680
4MP0003950_abnormal_plasma_membrane4.58374522
5MP0005195_abnormal_posterior_eye3.85749091
6MP0001324_abnormal_eye_pigmentation3.40316927
7MP0005391_vision/eye_phenotype3.31748068
8MP0002638_abnormal_pupillary_reflex2.91352834
9MP0002090_abnormal_vision2.79679359
10MP0005423_abnormal_somatic_nervous2.60093256
11MP0002229_neurodegeneration2.50517973
12MP0005410_abnormal_fertilization2.47243750
13MP0001764_abnormal_homeostasis2.44827174
14MP0001986_abnormal_taste_sensitivity2.23237409
15MP0003011_delayed_dark_adaptation10.3196767
16MP0002752_abnormal_somatic_nervous1.89465311
17MP0002653_abnormal_ependyma_morphology1.65413623
18MP0004019_abnormal_vitamin_homeostasis1.46668851
19MP0004233_abnormal_muscle_weight1.39829506
20MP0002882_abnormal_neuron_morphology1.28071196
21MP0001984_abnormal_olfaction1.24115861
22MP0003698_abnormal_male_reproductive1.04938575
23MP0001502_abnormal_circadian_rhythm1.02617921
24MP0004782_abnormal_surfactant_physiolog1.00824324
25MP0004885_abnormal_endolymph0.88087923
26MP0005197_abnormal_uvea_morphology0.84879282
27MP0002127_abnormal_cardiovascular_syste0.77317760
28MP0005187_abnormal_penis_morphology0.74772827
29MP0001929_abnormal_gametogenesis0.73982005
30MP0002332_abnormal_exercise_endurance0.72597776
31MP0003634_abnormal_glial_cell0.71643090
32MP0002272_abnormal_nervous_system0.64585475
33MP0001486_abnormal_startle_reflex0.64452300
34MP0005394_taste/olfaction_phenotype0.64137166
35MP0005499_abnormal_olfactory_system0.64137166
36MP0006292_abnormal_olfactory_placode0.61783237
37MP0008004_abnormal_stomach_pH0.61576456
38MP0005376_homeostasis/metabolism_phenot0.55017146
39MP0004270_analgesia0.54181268
40MP0009046_muscle_twitch0.54179161
41MP0002161_abnormal_fertility/fecundity0.51196615
42MP0001963_abnormal_hearing_physiology0.50100972
43MP0008789_abnormal_olfactory_epithelium0.49697321
44MP0001286_abnormal_eye_development0.42019586
45MP0003252_abnormal_bile_duct0.39722311
46MP0004145_abnormal_muscle_electrophysio0.37651772
47MP0001661_extended_life_span0.37562928
48MP0003646_muscle_fatigue0.37557728
49MP0002734_abnormal_mechanical_nocicepti0.37310096
50MP0002064_seizures0.36746716
51MP0008875_abnormal_xenobiotic_pharmacok0.35325011
52MP0005365_abnormal_bile_salt0.34003683
53MP0002067_abnormal_sensory_capabilities0.33733640
54MP0008058_abnormal_DNA_repair0.33417951
55MP0002572_abnormal_emotion/affect_behav0.31288919
56MP0003045_fibrosis0.31243288
57MP0000026_abnormal_inner_ear0.29687887
58MP0002210_abnormal_sex_determination0.29384018
59MP0002928_abnormal_bile_duct0.28949571
60MP0003635_abnormal_synaptic_transmissio0.28804800
61MP0005620_abnormal_muscle_contractility0.28629131
62MP0004085_abnormal_heartbeat0.28431255
63MP0001968_abnormal_touch/_nociception0.28351950
64MP0002063_abnormal_learning/memory/cond0.28268132
65MP0010386_abnormal_urinary_bladder0.28232751
66MP0003880_abnormal_central_pattern0.28042078
67MP0004043_abnormal_pH_regulation0.27620377
68MP0004215_abnormal_myocardial_fiber0.27543330
69MP0005670_abnormal_white_adipose0.26655931
70MP0000465_gastrointestinal_hemorrhage0.25049553
71MP0000631_abnormal_neuroendocrine_gland0.24942060
72MP0004036_abnormal_muscle_relaxation0.24839168
73MP0001145_abnormal_male_reproductive0.24580464
74MP0008877_abnormal_DNA_methylation0.23943759
75MP0005076_abnormal_cell_differentiation0.23701375
76MP0002108_abnormal_muscle_morphology0.23566686
77MP0000653_abnormal_sex_gland0.23457123
78MP0005595_abnormal_vascular_smooth0.21947983
79MP0005085_abnormal_gallbladder_physiolo0.19857800
80MP0004924_abnormal_behavior0.19083843
81MP0005386_behavior/neurological_phenoty0.19083843
82MP0009745_abnormal_behavioral_response0.18995543
83MP0004142_abnormal_muscle_tone0.18187439
84MP0008569_lethality_at_weaning0.18048962
85MP0002102_abnormal_ear_morphology0.17087190
86MP0001177_atelectasis0.16453379
87MP0000749_muscle_degeneration0.16277226
88MP0004742_abnormal_vestibular_system0.16250330
89MP0002066_abnormal_motor_capabilities/c0.15337730
90MP0002152_abnormal_brain_morphology0.14738506
91MP0010329_abnormal_lipoprotein_level0.14660014
92MP0002971_abnormal_brown_adipose0.13360665
93MP0000751_myopathy0.13312043
94MP0005360_urolithiasis0.13009953
95MP0003943_abnormal_hepatobiliary_system0.12830630
96MP0001905_abnormal_dopamine_level0.12793436
97MP0005319_abnormal_enzyme/_coenzyme0.12393717
98MP0010368_abnormal_lymphatic_system0.12290637
99MP0002234_abnormal_pharynx_morphology0.12180051
100MP0005646_abnormal_pituitary_gland0.11745775

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)9.92468335
2Dyschromatopsia (HP:0007641)9.54915216
3Pigmentary retinal degeneration (HP:0001146)9.25126489
4Chorioretinal atrophy (HP:0000533)8.48645685
5Attenuation of retinal blood vessels (HP:0007843)7.74428900
6Central scotoma (HP:0000603)7.63555768
7Abnormality of macular pigmentation (HP:0008002)7.62471468
8Pendular nystagmus (HP:0012043)7.48760090
9Scotoma (HP:0000575)6.88413569
10Decreased central vision (HP:0007663)6.56664578
11Abolished electroretinogram (ERG) (HP:0000550)6.33345455
12Photophobia (HP:0000613)5.73254901
13Type II diabetes mellitus (HP:0005978)5.65072754
14Vitreoretinal degeneration (HP:0000655)5.24651117
15Macular degeneration (HP:0000608)4.97521648
16Cone-rod dystrophy (HP:0000548)4.73271774
17Keratoconus (HP:0000563)4.69326288
18Increased corneal curvature (HP:0100692)4.69326288
19Choroideremia (HP:0001139)4.61270335
20Retinitis pigmentosa (HP:0000510)4.55196092
21Severe visual impairment (HP:0001141)4.55048166
22Constricted visual fields (HP:0001133)4.20127615
23Posterior subcapsular cataract (HP:0007787)3.98848261
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.56158986
25Retinal atrophy (HP:0001105)2.89616129
26Progressive visual loss (HP:0000529)2.82152020
27Gait imbalance (HP:0002141)2.80013263
28Congenital primary aphakia (HP:0007707)2.79332664
29Optic disc pallor (HP:0000543)2.75672310
30Medial flaring of the eyebrow (HP:0010747)2.63717608
31Subcapsular cataract (HP:0000523)2.63503996
32Congenital sensorineural hearing impairment (HP:0008527)2.51668257
33Wide nasal bridge (HP:0000431)2.49462558
34Nephrogenic diabetes insipidus (HP:0009806)2.46873892
35Poor coordination (HP:0002370)2.14493158
36Absent/shortened dynein arms (HP:0200106)2.06729148
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.06729148
38Congenital stationary night blindness (HP:0007642)14.6304803
39Bony spicule pigmentary retinopathy (HP:0007737)11.5320231
40Absent rod-and cone-mediated responses on ERG (HP:0007688)10.0314317
41Vaginal atresia (HP:0000148)1.96998614
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92465449
43Genital tract atresia (HP:0001827)1.89694530
44True hermaphroditism (HP:0010459)1.71197268
45Aplasia/Hypoplasia of the lens (HP:0008063)1.63999591
46Optic atrophy (HP:0000648)1.63760901
47Pancreatic fibrosis (HP:0100732)1.58905209
48Interstitial pulmonary disease (HP:0006530)1.54731250
49Horizontal nystagmus (HP:0000666)1.53088135
50Abnormal respiratory motile cilium physiology (HP:0012261)1.44858210
51Recurrent sinusitis (HP:0011108)1.43262218
52Severe Myopia (HP:0011003)1.41919385
53Polar cataract (HP:0010696)1.38372492
54Abnormal respiratory motile cilium morphology (HP:0005938)1.34745988
55Abnormal respiratory epithelium morphology (HP:0012253)1.34745988
56Dysdiadochokinesis (HP:0002075)1.32425707
57Astigmatism (HP:0000483)1.31040649
58Molar tooth sign on MRI (HP:0002419)1.25925013
59Abnormality of midbrain morphology (HP:0002418)1.25925013
60Cystic liver disease (HP:0006706)1.24479075
61Nephronophthisis (HP:0000090)1.22837769
62Pancreatic cysts (HP:0001737)1.22615162
63Cerebellar dysplasia (HP:0007033)1.21448238
64Abnormal ciliary motility (HP:0012262)1.17700791
65Broad foot (HP:0001769)1.13639914
66Retinal detachment (HP:0000541)1.12385392
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.10027277
68Left ventricular hypertrophy (HP:0001712)1.10023475
69Decreased testicular size (HP:0008734)1.09614633
70Rhinitis (HP:0012384)1.08978964
71Chronic hepatic failure (HP:0100626)1.07845074
72Epileptic encephalopathy (HP:0200134)1.07045023
73Specific learning disability (HP:0001328)1.06222226
74Asthma (HP:0002099)1.04029019
75Abnormality of the renal medulla (HP:0100957)1.03860219
76Abnormality of the fovea (HP:0000493)1.03281084
77Chronic bronchitis (HP:0004469)1.02676531
78Aplasia/Hypoplasia of the fovea (HP:0008060)1.01158791
79Hypoplasia of the fovea (HP:0007750)1.01158791
80Progressive cerebellar ataxia (HP:0002073)0.98141715
81Chorioretinal coloboma (HP:0000567)0.93859839
82Postaxial hand polydactyly (HP:0001162)0.92895368
83Partial agenesis of the corpus callosum (HP:0001338)0.92877518
84Congenital hepatic fibrosis (HP:0002612)0.92191869
85Truncal ataxia (HP:0002078)0.90963736
86Tubulointerstitial nephritis (HP:0001970)0.90882495
87Aplasia/Hypoplasia of the macula (HP:0008059)0.88739787
88Sclerocornea (HP:0000647)0.87193504
89Recurrent otitis media (HP:0000403)0.86815275
90Hypodontia (HP:0000668)0.83892453
91Postaxial foot polydactyly (HP:0001830)0.83606401
92Dental crowding (HP:0000678)0.83026330
93Febrile seizures (HP:0002373)0.82878141
94Infertility (HP:0000789)0.82764092
95Aplasia/Hypoplasia affecting the retina (HP:0008061)0.81541704
96Cholecystitis (HP:0001082)0.80944063
97Abnormal gallbladder physiology (HP:0012438)0.80944063
98Hypermetropia (HP:0000540)0.79717742
99Furrowed tongue (HP:0000221)0.79329799
100Abnormality of dental color (HP:0011073)0.73669013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.34829555
2PBK7.66115919
3PDK43.22718336
4PDK33.22718336
5PINK13.08343075
6PDK22.83220040
7ICK2.33405077
8PRKD32.27330995
9IRAK22.23135084
10STK381.69392071
11CCNB11.56491858
12ADRBK11.38784248
13TESK11.35250637
14MAPK71.29295228
15INSRR1.27328841
16PNCK1.17335064
17CAMK1G1.15027088
18TAOK31.14986435
19DYRK1B1.13455982
20SGK4941.11183655
21SGK2231.11183655
22AKT31.08425995
23MAPK121.06927283
24PRKCZ0.98280705
25TTK0.96166406
26SIK20.95991199
27SGK20.95812042
28WNK40.95544043
29CAMK1D0.92480261
30RPS6KA40.92355389
31MARK10.90075623
32WNK10.89810837
33NEK20.89395273
34PRKAA10.84082415
35CDK120.83786449
36STK390.83170504
37BRD40.83013278
38STK38L0.81625367
39LMTK20.81379476
40NEK10.79773120
41CSNK1D0.78705451
42NEK60.71428601
43SGK30.70896816
44MAP3K100.70497710
45CDK30.70063388
46DYRK1A0.65227082
47FRK0.64644120
48PRKAA20.62958957
49PHKG10.62461137
50PHKG20.62461137
51MAP3K40.62309218
52HIPK20.62003304
53PRKACG0.60345502
54MYLK0.58471836
55PAK60.58419964
56PRKCB0.55155325
57CAMKK10.52540597
58PRKCH0.52198929
59PRKCG0.51437215
60CAMK2D0.49640006
61ERBB20.48056248
62PTK2B0.47340223
63PKN10.47013982
64FGFR20.46319317
65PDK10.45818019
66RPS6KA30.43266379
67CHEK20.43009555
68IRAK10.42792941
69PLK30.40621177
70GSK3B0.37465871
71LATS10.36591672
72FES0.35576679
73PRKDC0.33892085
74CAMK10.33582978
75MAP2K70.33349560
76CAMK2A0.32676656
77PRKD20.32581807
78CASK0.31907096
79PRKACA0.31724684
80GRK50.30335013
81RPS6KB10.29904658
82PLK20.29818760
83SGK10.28847092
84CHEK10.27955123
85AKT20.27179472
86MAPK90.26407374
87PRKCA0.24939432
88CDK10.24363157
89MAPK100.24324857
90MAPK140.23671413
91PDPK10.22756827
92SIK10.21924536
93EPHA30.21652191
94ATM0.21009134
95STK110.20993698
96CDK50.20234267
97MAP3K70.16698000
98ATR0.16448821
99MKNK20.15855027
100CSNK1E0.15601081

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa0474415.8925661
2Synaptic vesicle cycle_Homo sapiens_hsa047211.45568642
3Olfactory transduction_Homo sapiens_hsa047401.25871089
4Retinol metabolism_Homo sapiens_hsa008301.03173817
5GABAergic synapse_Homo sapiens_hsa047271.00634541
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96366767
7Circadian rhythm_Homo sapiens_hsa047100.86502916
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78049023
9Caffeine metabolism_Homo sapiens_hsa002320.77360714
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74054463
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72829953
12Morphine addiction_Homo sapiens_hsa050320.71393989
13ABC transporters_Homo sapiens_hsa020100.71298969
14Cholinergic synapse_Homo sapiens_hsa047250.70963370
15Circadian entrainment_Homo sapiens_hsa047130.68120704
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66778496
17Dopaminergic synapse_Homo sapiens_hsa047280.62981069
18Glutamatergic synapse_Homo sapiens_hsa047240.62636455
19Purine metabolism_Homo sapiens_hsa002300.61974429
20Fructose and mannose metabolism_Homo sapiens_hsa000510.60137947
21Glycerolipid metabolism_Homo sapiens_hsa005610.52969569
22Insulin secretion_Homo sapiens_hsa049110.49996000
23Serotonergic synapse_Homo sapiens_hsa047260.49941671
24cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48019574
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47808927
26Nicotine addiction_Homo sapiens_hsa050330.47629081
27Glycerophospholipid metabolism_Homo sapiens_hsa005640.46536283
28Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45178194
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42777946
30Fatty acid biosynthesis_Homo sapiens_hsa000610.42578540
31Pyruvate metabolism_Homo sapiens_hsa006200.41798627
32Glucagon signaling pathway_Homo sapiens_hsa049220.41488129
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40870445
34Linoleic acid metabolism_Homo sapiens_hsa005910.40753722
35Fatty acid elongation_Homo sapiens_hsa000620.40631187
36Cardiac muscle contraction_Homo sapiens_hsa042600.40610265
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39612106
38Vitamin B6 metabolism_Homo sapiens_hsa007500.37699917
39Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37626262
40Biosynthesis of amino acids_Homo sapiens_hsa012300.37578171
41Inositol phosphate metabolism_Homo sapiens_hsa005620.36477680
42Arginine biosynthesis_Homo sapiens_hsa002200.31811866
43Drug metabolism - other enzymes_Homo sapiens_hsa009830.31716001
44Renin secretion_Homo sapiens_hsa049240.28394787
45Nitrogen metabolism_Homo sapiens_hsa009100.27943673
46Fat digestion and absorption_Homo sapiens_hsa049750.27807036
47Mineral absorption_Homo sapiens_hsa049780.27317922
48Oxytocin signaling pathway_Homo sapiens_hsa049210.26980151
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26978924
50cAMP signaling pathway_Homo sapiens_hsa040240.26616595
51Bile secretion_Homo sapiens_hsa049760.25381962
52Salivary secretion_Homo sapiens_hsa049700.23900943
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.23881561
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22706846
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.22661203
56Collecting duct acid secretion_Homo sapiens_hsa049660.21965099
57Carbon metabolism_Homo sapiens_hsa012000.21307844
58Dilated cardiomyopathy_Homo sapiens_hsa054140.20557278
59Fatty acid metabolism_Homo sapiens_hsa012120.20442442
60Gastric acid secretion_Homo sapiens_hsa049710.20142366
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19997373
62Galactose metabolism_Homo sapiens_hsa000520.19772886
63Pentose phosphate pathway_Homo sapiens_hsa000300.19242442
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19129030
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.19066482
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18776792
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17985242
68Calcium signaling pathway_Homo sapiens_hsa040200.17878504
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17505812
70Amphetamine addiction_Homo sapiens_hsa050310.17463803
71Ether lipid metabolism_Homo sapiens_hsa005650.17331226
72PPAR signaling pathway_Homo sapiens_hsa033200.16780426
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16727744
74AMPK signaling pathway_Homo sapiens_hsa041520.15738628
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15553633
76Alcoholism_Homo sapiens_hsa050340.14737795
77Vitamin digestion and absorption_Homo sapiens_hsa049770.14524942
78mRNA surveillance pathway_Homo sapiens_hsa030150.14044136
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13500876
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13304732
81Lysine degradation_Homo sapiens_hsa003100.12510789
82Cocaine addiction_Homo sapiens_hsa050300.12397226
83mTOR signaling pathway_Homo sapiens_hsa041500.12055904
84Pancreatic secretion_Homo sapiens_hsa049720.11604233
85Fatty acid degradation_Homo sapiens_hsa000710.10744024
86Long-term potentiation_Homo sapiens_hsa047200.10146201
87HIF-1 signaling pathway_Homo sapiens_hsa040660.09511145
88Propanoate metabolism_Homo sapiens_hsa006400.09234852
89Thyroid hormone synthesis_Homo sapiens_hsa049180.08743135
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.08704059
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.08306275
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07972610
93Taste transduction_Homo sapiens_hsa047420.07750218
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.07630406
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.07260456
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.06969136
97Type II diabetes mellitus_Homo sapiens_hsa049300.06328060
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06263144
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05857756
100Oocyte meiosis_Homo sapiens_hsa041140.04752670

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