F5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.42769331
2L-phenylalanine catabolic process (GO:0006559)7.42769331
3L-phenylalanine metabolic process (GO:0006558)7.07488679
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.07488679
5aromatic amino acid family catabolic process (GO:0009074)6.70519877
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.24856261
7tryptophan catabolic process (GO:0006569)6.06077900
8indole-containing compound catabolic process (GO:0042436)6.06077900
9indolalkylamine catabolic process (GO:0046218)6.06077900
10complement activation, alternative pathway (GO:0006957)6.05601074
11kynurenine metabolic process (GO:0070189)5.94304212
12bile acid biosynthetic process (GO:0006699)5.89871863
13urea metabolic process (GO:0019627)5.74792706
14urea cycle (GO:0000050)5.74792706
15regulation of protein activation cascade (GO:2000257)5.73049414
16tryptophan metabolic process (GO:0006568)5.72237494
17alpha-linolenic acid metabolic process (GO:0036109)5.68674958
18negative regulation of fibrinolysis (GO:0051918)5.63720143
19glyoxylate metabolic process (GO:0046487)5.63344098
20peptidyl-glutamic acid carboxylation (GO:0017187)5.57151178
21protein carboxylation (GO:0018214)5.57151178
22negative regulation of protein activation cascade (GO:2000258)5.53504047
23high-density lipoprotein particle remodeling (GO:0034375)5.46626370
24regulation of fibrinolysis (GO:0051917)5.44715014
25regulation of complement activation (GO:0030449)5.40592383
26intestinal cholesterol absorption (GO:0030299)5.35451095
27regulation of plasminogen activation (GO:0010755)5.29177950
28nitrogen cycle metabolic process (GO:0071941)5.26606568
29regulation of apoptotic cell clearance (GO:2000425)5.21979702
30sulfur amino acid catabolic process (GO:0000098)5.20210751
31cysteine metabolic process (GO:0006534)5.20119015
32bile acid metabolic process (GO:0008206)5.05620710
33serine family amino acid catabolic process (GO:0009071)4.98173544
34regulation of humoral immune response (GO:0002920)4.97501069
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.92973605
36epoxygenase P450 pathway (GO:0019373)4.90616255
37aromatic amino acid family metabolic process (GO:0009072)4.84511586
38reverse cholesterol transport (GO:0043691)4.83261708
39regulation of cholesterol esterification (GO:0010872)4.76762746
40homocysteine metabolic process (GO:0050667)4.76732064
41tyrosine metabolic process (GO:0006570)4.74193432
42exogenous drug catabolic process (GO:0042738)4.73291414
43protein-lipid complex remodeling (GO:0034368)4.72447960
44macromolecular complex remodeling (GO:0034367)4.72447960
45plasma lipoprotein particle remodeling (GO:0034369)4.72447960
46regulation of triglyceride catabolic process (GO:0010896)4.72301652
47negative regulation of complement activation (GO:0045916)4.70871529
48positive regulation of hemostasis (GO:1900048)4.63313354
49positive regulation of blood coagulation (GO:0030194)4.63313354
50protein-lipid complex subunit organization (GO:0071825)4.62577018
51phospholipid efflux (GO:0033700)4.57664890
52negative regulation of blood coagulation (GO:0030195)4.54042663
53negative regulation of hemostasis (GO:1900047)4.54042663
54amino-acid betaine metabolic process (GO:0006577)4.53892753
55alpha-amino acid catabolic process (GO:1901606)4.53532741
56acylglycerol homeostasis (GO:0055090)4.52674181
57triglyceride homeostasis (GO:0070328)4.52674181
58negative regulation of sterol transport (GO:0032372)4.50145496
59negative regulation of cholesterol transport (GO:0032375)4.50145496
60lysine catabolic process (GO:0006554)4.47173601
61lysine metabolic process (GO:0006553)4.47173601
62plasma lipoprotein particle clearance (GO:0034381)4.44334072
63bile acid and bile salt transport (GO:0015721)4.42889254
64imidazole-containing compound metabolic process (GO:0052803)4.34894832
65positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.33500211
66indolalkylamine metabolic process (GO:0006586)4.28173529
67glycine metabolic process (GO:0006544)4.27862472
68cellular ketone body metabolic process (GO:0046950)4.26583260
69positive regulation of coagulation (GO:0050820)4.25832877
70cholesterol efflux (GO:0033344)4.25176031
71cellular glucuronidation (GO:0052695)4.23854345
72coenzyme catabolic process (GO:0009109)4.23149618
73omega-hydroxylase P450 pathway (GO:0097267)4.18961252
74cellular amino acid catabolic process (GO:0009063)4.16330744
75amine catabolic process (GO:0009310)4.16314114
76cellular biogenic amine catabolic process (GO:0042402)4.16314114
77glutamate metabolic process (GO:0006536)4.14396209
78complement activation (GO:0006956)4.13657195
79negative regulation of coagulation (GO:0050819)4.12813408
80fibrinolysis (GO:0042730)4.07760000
81low-density lipoprotein particle remodeling (GO:0034374)4.07523522
82ethanol oxidation (GO:0006069)4.07140066
83complement activation, classical pathway (GO:0006958)4.04608929
84plasma lipoprotein particle assembly (GO:0034377)4.03445316
85serine family amino acid metabolic process (GO:0009069)4.02249274
86benzene-containing compound metabolic process (GO:0042537)4.01857248
87protein activation cascade (GO:0072376)3.99689547
88cellular modified amino acid catabolic process (GO:0042219)3.99536386
89dicarboxylic acid biosynthetic process (GO:0043650)3.98061078
90negative regulation of wound healing (GO:0061045)3.95982493
91opsonization (GO:0008228)3.91113940
92arginine metabolic process (GO:0006525)3.90449649
93positive regulation of extracellular matrix organization (GO:1903055)3.88521180
94negative regulation of humoral immune response (GO:0002921)3.87409408
95aldehyde catabolic process (GO:0046185)3.86538951
96blood coagulation, intrinsic pathway (GO:0007597)3.83853350
97phospholipid homeostasis (GO:0055091)3.83278688
98serine family amino acid biosynthetic process (GO:0009070)3.82688651
99drug catabolic process (GO:0042737)3.77594972
100positive regulation of lipid catabolic process (GO:0050996)3.76666919
101uronic acid metabolic process (GO:0006063)3.73838691
102glucuronate metabolic process (GO:0019585)3.73838691
103cholesterol homeostasis (GO:0042632)3.72851792
104very-low-density lipoprotein particle assembly (GO:0034379)3.71669225
105cofactor catabolic process (GO:0051187)3.68999090
106positive regulation of triglyceride lipase activity (GO:0061365)3.68531095
107positive regulation of lipoprotein lipase activity (GO:0051006)3.68531095
108ketone body metabolic process (GO:1902224)3.68066510
109lipoprotein metabolic process (GO:0042157)3.66794715
110sterol homeostasis (GO:0055092)3.66680277
111regulation of bile acid biosynthetic process (GO:0070857)3.66617563
112positive regulation of fatty acid biosynthetic process (GO:0045723)3.65962059
113regulation of cholesterol homeostasis (GO:2000188)3.65023824
114carboxylic acid catabolic process (GO:0046395)3.64229938
115organic acid catabolic process (GO:0016054)3.64229938
116protein-lipid complex assembly (GO:0065005)3.63448399
117negative regulation of lipase activity (GO:0060192)3.63439485
118cytolysis (GO:0019835)3.63267006
119plasma lipoprotein particle organization (GO:0071827)3.62756179
120acetyl-CoA metabolic process (GO:0006084)3.57974555
121ethanol metabolic process (GO:0006067)3.57196483
122acute-phase response (GO:0006953)3.54559787
123killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.52986862
124disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.52986862
125positive regulation of fatty acid beta-oxidation (GO:0032000)3.52494784
126acute inflammatory response (GO:0002526)3.48551883
127intestinal absorption (GO:0050892)3.47895415
128sterol transport (GO:0015918)3.41492544
129cholesterol transport (GO:0030301)3.41492544
130regulation of acute inflammatory response (GO:0002673)3.36275574
131regulation of cholesterol biosynthetic process (GO:0045540)3.33924915
132drug metabolic process (GO:0017144)3.27614949
133positive regulation of steroid metabolic process (GO:0045940)3.26510711
134diacylglycerol metabolic process (GO:0046339)3.25162411
135regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.18429587
136response to mercury ion (GO:0046689)3.15275345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.28112482
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.06355085
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.89760296
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.49142950
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.20388944
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.92486654
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.57758413
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.08360789
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.86005083
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04412472
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7696221
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91716914
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82868038
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81731683
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78632209
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.66809378
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64434779
18HTT_18923047_ChIP-ChIP_STHdh_Human1.54837769
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53587538
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51518305
21CLOCK_20551151_ChIP-Seq_293T_Human1.49954184
22TCF4_18268006_ChIP-ChIP_LS174T_Human1.49278085
23GATA1_22025678_ChIP-Seq_K562_Human1.42724954
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39168758
25RUNX_20019798_ChIP-Seq_JUKART_Human1.25694651
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20073218
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.19499921
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15263589
29RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13305031
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08425358
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05399402
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.04137898
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02293714
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99105023
35CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99017752
36* IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93567732
37CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93157967
38RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92338561
39* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90773409
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90217440
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87477454
42* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86939804
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86922753
44CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85433306
45MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83003016
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82957992
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82609649
48NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82565932
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82145489
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80541918
51GATA4_25053715_ChIP-Seq_YYC3_Human0.79910225
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79233336
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78064258
54GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77121325
55PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77115224
56AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76766084
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75375039
58NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75375039
59* SOX2_20726797_ChIP-Seq_SW620_Human0.75333626
60HIF1A_21447827_ChIP-Seq_MCF-7_Human0.75304586
61GATA2_21666600_ChIP-Seq_HMVEC_Human0.74735311
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73632104
63POU5F1_16518401_ChIP-PET_MESCs_Mouse0.73603447
64TCF7_22412390_ChIP-Seq_EML_Mouse0.73453791
65IRF8_21731497_ChIP-ChIP_J774_Mouse0.72868727
66SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72635608
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71740108
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.71323053
69ESR2_21235772_ChIP-Seq_MCF-7_Human0.70749974
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70518154
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70371646
72SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70027656
73* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68797276
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68134432
75SPI1_23127762_ChIP-Seq_K562_Human0.67223332
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.67130118
77* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66715470
78RARA_24833708_ChIP-Seq_LIVER_Mouse0.66404420
79KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65968297
80STAT4_19710469_ChIP-ChIP_TH1__Mouse0.64850694
81* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.64351260
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.63732597
83STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.63657248
84* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63565475
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.62799522
86TP53_16413492_ChIP-PET_HCT116_Human0.62765304
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.61878624
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.61120811
89* PU_27001747_Chip-Seq_BMDM_Mouse0.60274913
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.59559060
91VDR_24787735_ChIP-Seq_THP-1_Human0.59353552
92GATA2_22383799_ChIP-Seq_G1ME_Mouse0.59159045
93LXR_22292898_ChIP-Seq_THP-1_Human0.57142300
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.56445524
95RARB_24833708_ChIP-Seq_LIVER_Mouse0.56290111
96FOXA1_25552417_ChIP-Seq_VCAP_Human0.55291233
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.54927336
98EGR1_19032775_ChIP-ChIP_M12_Human0.54740069
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54421816
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.54301810
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53158682
102GATA2_19941826_ChIP-Seq_K562_Human0.52788724
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.52769136
104* CEBPB_22108803_ChIP-Seq_LS180_Human0.52710895
105ZNF263_19887448_ChIP-Seq_K562_Human0.52450123
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.51153283
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.50462968
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.50368077
109GATA1_19941826_ChIP-Seq_K562_Human0.50184070
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.48983715
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.48826967
112MYC_19915707_ChIP-ChIP_AK7_Human0.48724142
113ESET_19884257_ChIP-Seq_ESCs_Mouse0.48326082
114PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48257889
115FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47959024
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.47379406
117AR_20517297_ChIP-Seq_VCAP_Human0.47349334
118BCAT_22108803_ChIP-Seq_LS180_Human0.47278661
119STAT1_17558387_ChIP-Seq_HELA_Human0.46888674
120* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.45053810
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43363693
122* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43167498
123CBP_21632823_ChIP-Seq_H3396_Human0.42618844
124* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.42227251
125IRF8_27001747_Chip-Seq_BMDM_Mouse0.42219196
126P53_21459846_ChIP-Seq_SAOS-2_Human0.42093454
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.41929321
128BRD4_27068464_Chip-Seq_AML-cells_Mouse0.41783216
129TAF15_26573619_Chip-Seq_HEK293_Human0.41525938
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.40941378
131* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39996911
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.39580306
133GATA6_25053715_ChIP-Seq_YYC3_Human0.39500424
134TAF2_19829295_ChIP-Seq_ESCs_Human0.38866878
135MYC_27129775_Chip-Seq_CORNEA_Mouse0.38107907
136CDX2_22108803_ChIP-Seq_LS180_Human0.37959236
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.37729525
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.37483452
139BP1_19119308_ChIP-ChIP_Hs578T_Human0.37153697
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.35721046
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.35615528
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.35088091
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.34944632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.14409985
2MP0005360_urolithiasis7.48028282
3MP0005085_abnormal_gallbladder_physiolo6.38148650
4MP0005365_abnormal_bile_salt6.09558671
5MP0008875_abnormal_xenobiotic_pharmacok5.04445173
6MP0003806_abnormal_nucleotide_metabolis4.06006683
7MP0003252_abnormal_bile_duct3.95110069
8MP0010329_abnormal_lipoprotein_level3.58875471
9MP0009840_abnormal_foam_cell3.35510095
10MP0003122_maternal_imprinting3.07448270
11MP0005083_abnormal_biliary_tract3.05254486
12MP0005332_abnormal_amino_acid2.69987093
13MP0003195_calcinosis2.68456678
14MP0001666_abnormal_nutrient_absorption2.56234412
15MP0003191_abnormal_cellular_cholesterol2.32865634
16MP0000609_abnormal_liver_physiology2.17071231
17MP0004019_abnormal_vitamin_homeostasis2.13898695
18MP0002118_abnormal_lipid_homeostasis2.07820134
19MP0002138_abnormal_hepatobiliary_system1.92397489
20MP0003868_abnormal_feces_composition1.92198791
21MP0003172_abnormal_lysosome_physiology1.85095797
22MP0005319_abnormal_enzyme/_coenzyme1.79745187
23MP0001764_abnormal_homeostasis1.59716379
24MP0005584_abnormal_enzyme/coenzyme_acti1.54960470
25MP0009697_abnormal_copulation1.50574850
26MP0003011_delayed_dark_adaptation1.37097223
27MP0002089_abnormal_postnatal_growth/wei1.32289709
28MP0003705_abnormal_hypodermis_morpholog1.31419554
29MP0005451_abnormal_body_composition1.29650987
30MP0003656_abnormal_erythrocyte_physiolo1.28682584
31* MP0001915_intracranial_hemorrhage1.27144247
32MP0009643_abnormal_urine_homeostasis1.22292268
33* MP0000598_abnormal_liver_morphology1.18351863
34MP0003186_abnormal_redox_activity1.16220958
35MP0010368_abnormal_lymphatic_system1.14000338
36MP0005647_abnormal_sex_gland1.11866096
37MP0000604_amyloidosis1.11414989
38MP0009763_increased_sensitivity_to1.11058467
39MP0009764_decreased_sensitivity_to1.09686096
40MP0002254_reproductive_system_inflammat1.08126843
41MP0005164_abnormal_response_to1.01491684
42MP0000685_abnormal_immune_system0.99979729
43MP0003183_abnormal_peptide_metabolism0.99111745
44MP0009785_altered_susceptibility_to0.95641743
45MP0003123_paternal_imprinting0.94271741
46MP0008469_abnormal_protein_level0.93534269
47MP0009642_abnormal_blood_homeostasis0.86562509
48MP0005409_darkened_coat_color0.86274684
49MP0005670_abnormal_white_adipose0.86178783
50MP0008260_abnormal_autophagy0.85866320
51MP0005220_abnormal_exocrine_pancreas0.84784831
52MP0005636_abnormal_mineral_homeostasis0.83894264
53MP0000566_synostosis0.82192688
54MP0005408_hypopigmentation0.81591061
55MP0002933_joint_inflammation0.80402426
56MP0001661_extended_life_span0.80142489
57MP0002419_abnormal_innate_immunity0.79277867
58MP0003303_peritoneal_inflammation0.78708001
59MP0005167_abnormal_blood-brain_barrier0.78349234
60MP0003879_abnormal_hair_cell0.78210996
61MP0005025_abnormal_response_to0.77591492
62MP0009765_abnormal_xenobiotic_induced0.76874969
63MP0009053_abnormal_anal_canal0.75635856
64MP0002971_abnormal_brown_adipose0.75446896
65MP0005376_homeostasis/metabolism_phenot0.74050397
66MP0004264_abnormal_extraembryonic_tissu0.73901681
67MP0002078_abnormal_glucose_homeostasis0.73839197
68MP0000858_altered_metastatic_potential0.73009157
69MP0002166_altered_tumor_susceptibility0.72729027
70MP0003724_increased_susceptibility_to0.71767647
71MP0003690_abnormal_glial_cell0.71362987
72MP0005334_abnormal_fat_pad0.69723908
73MP0006054_spinal_hemorrhage0.69406599
74MP0005084_abnormal_gallbladder_morpholo0.68960315
75MP0001533_abnormal_skeleton_physiology0.68571995
76MP0003436_decreased_susceptibility_to0.68498163
77MP0002876_abnormal_thyroid_physiology0.68494865
78MP0004130_abnormal_muscle_cell0.68078623
79MP0000639_abnormal_adrenal_gland0.67822173
80MP0009333_abnormal_splenocyte_physiolog0.66816738
81MP0005535_abnormal_body_temperature0.66564165
82MP0005464_abnormal_platelet_physiology0.66219370
83MP0000920_abnormal_myelination0.66089067
84MP0003878_abnormal_ear_physiology0.65545375
85MP0005377_hearing/vestibular/ear_phenot0.65545375
86MP0005076_abnormal_cell_differentiation0.65019899
87MP0006036_abnormal_mitochondrial_physio0.64530928
88MP0005248_abnormal_Harderian_gland0.62815467
89MP0003632_abnormal_nervous_system0.59900372
90MP0003121_genomic_imprinting0.58933391
91MP0001756_abnormal_urination0.57568483
92MP0003329_amyloid_beta_deposits0.57379881
93MP0002909_abnormal_adrenal_gland0.56632096
94MP0003638_abnormal_response/metabolism_0.55442534
95MP0005448_abnormal_energy_balance0.55250302
96MP0005266_abnormal_metabolism0.54896255
97MP0003075_altered_response_to0.54812052
98MP0003866_abnormal_defecation0.54197684
99MP0005395_other_phenotype0.53424799
100MP0002928_abnormal_bile_duct0.53093432
101MP0002405_respiratory_system_inflammati0.50360353
102MP0001790_abnormal_immune_system0.49786590
103MP0005387_immune_system_phenotype0.49786590
104MP0001800_abnormal_humoral_immune0.49627240
105MP0002168_other_aberrant_phenotype0.48235468
106MP0003943_abnormal_hepatobiliary_system0.48172562
107MP0002136_abnormal_kidney_physiology0.47803487
108MP0001851_eye_inflammation0.47654409
109MP0000579_abnormal_nail_morphology0.46883475
110MP0008874_decreased_physiological_sensi0.44188338
111MP0008873_increased_physiological_sensi0.43381478
112MP0005058_abnormal_lysosome_morphology0.42875326
113MP0005166_decreased_susceptibility_to0.42493281
114MP0004381_abnormal_hair_follicle0.41512978
115MP0000249_abnormal_blood_vessel0.41011196
116MP0006035_abnormal_mitochondrial_morpho0.40969255
117MP0004782_abnormal_surfactant_physiolog0.40488774
118MP0001243_abnormal_dermal_layer0.39148351
119MP0005187_abnormal_penis_morphology0.38805648
120MP0001853_heart_inflammation0.38275835
121MP0005666_abnormal_adipose_tissue0.37648608
122MP0004883_abnormal_blood_vessel0.37594808
123MP0003953_abnormal_hormone_level0.35960764
124MP0001845_abnormal_inflammatory_respons0.35874842
125MP0009672_abnormal_birth_weight0.34613266
126MP0000427_abnormal_hair_cycle0.34284923
127MP0009115_abnormal_fat_cell0.33198693
128MP0002132_abnormal_respiratory_system0.33134401
129MP0003718_maternal_effect0.32758840
130MP0006082_CNS_inflammation0.31968313
131MP0009384_cardiac_valve_regurgitation0.31808625
132MP0005023_abnormal_wound_healing0.31165784
133MP0000230_abnormal_systemic_arterial0.30832249
134MP0002970_abnormal_white_adipose0.28980723
135MP0004947_skin_inflammation0.28818026
136MP0003300_gastrointestinal_ulcer0.28775758
137MP0002135_abnormal_kidney_morphology0.27964364
138MP0001881_abnormal_mammary_gland0.27816638

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.35197609
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.29515281
3* Deep venous thrombosis (HP:0002625)7.26736986
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.69549213
5Hypobetalipoproteinemia (HP:0003563)6.42790760
6* Prolonged partial thromboplastin time (HP:0003645)6.40552085
7Xanthomatosis (HP:0000991)6.37549508
8Complement deficiency (HP:0004431)6.13196106
9Hyperlipoproteinemia (HP:0010980)5.51851226
10Joint hemorrhage (HP:0005261)5.04147048
11Hypolipoproteinemia (HP:0010981)4.83041374
12Abnormality of complement system (HP:0005339)4.63203225
13Epidermoid cyst (HP:0200040)4.62625536
14Hyperammonemia (HP:0001987)4.53097243
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42195205
16* Abnormality of the common coagulation pathway (HP:0010990)4.33000059
17Hyperglycinemia (HP:0002154)4.29344867
18Abnormality of methionine metabolism (HP:0010901)4.28110332
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.26124132
20Hypoalphalipoproteinemia (HP:0003233)4.23425881
21Ketosis (HP:0001946)4.15875687
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12012310
23Fat malabsorption (HP:0002630)4.11678127
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09295575
25Systemic lupus erythematosus (HP:0002725)3.82807102
26Abnormality of pyrimidine metabolism (HP:0004353)3.80140559
27Abnormality of the intrinsic pathway (HP:0010989)3.78833556
28Hypoglycemic coma (HP:0001325)3.78015775
29Conjugated hyperbilirubinemia (HP:0002908)3.77084175
30Hypercholesterolemia (HP:0003124)3.74557922
31Abnormality of glycine metabolism (HP:0010895)3.74084532
32Abnormality of serine family amino acid metabolism (HP:0010894)3.74084532
33Hyperglycinuria (HP:0003108)3.73341642
34Purpura (HP:0000979)3.46191519
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29640696
36Hyperbilirubinemia (HP:0002904)3.29513717
37Delayed CNS myelination (HP:0002188)3.24548887
38Glomerulonephritis (HP:0000099)3.22626167
39Abnormality of fatty-acid metabolism (HP:0004359)3.21392386
40Myocardial infarction (HP:0001658)3.08337564
41Steatorrhea (HP:0002570)3.03069634
42Abnormality of nucleobase metabolism (HP:0010932)3.02834948
43Spontaneous abortion (HP:0005268)3.02736673
44Hypochromic microcytic anemia (HP:0004840)2.96849708
45Abnormality of serum amino acid levels (HP:0003112)2.95606159
46Recurrent gram-negative bacterial infections (HP:0005420)2.95082841
47Hepatocellular carcinoma (HP:0001402)2.94813416
48Osteomalacia (HP:0002749)2.93347406
49Arthropathy (HP:0003040)2.89172322
50Ketoacidosis (HP:0001993)2.87150733
51Skin nodule (HP:0200036)2.85226016
52Vascular calcification (HP:0004934)2.64811339
53Abnormality of purine metabolism (HP:0004352)2.64182142
54Acanthocytosis (HP:0001927)2.64044130
55Metabolic acidosis (HP:0001942)2.60937595
56Mitral stenosis (HP:0001718)2.60188967
57Retrobulbar optic neuritis (HP:0100654)2.52447469
58Optic neuritis (HP:0100653)2.52447469
59Abnormality of carpal bone ossification (HP:0006257)2.48994931
60Gingival bleeding (HP:0000225)2.45271847
61Abnormal tarsal ossification (HP:0008369)2.44526878
62Dicarboxylic aciduria (HP:0003215)2.44254291
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44254291
64Hypoglycemic seizures (HP:0002173)2.43611621
65Orchitis (HP:0100796)2.42598669
66Lethargy (HP:0001254)2.42504726
67Spastic diplegia (HP:0001264)2.40809955
68Abnormal gallbladder morphology (HP:0012437)2.39963354
69Cardiovascular calcification (HP:0011915)2.38199015
70Cholelithiasis (HP:0001081)2.33605283
71Amyloidosis (HP:0011034)2.31576242
72Irritability (HP:0000737)2.31415564
73Abnormal gallbladder physiology (HP:0012438)2.30037070
74Cholecystitis (HP:0001082)2.30037070
75Joint swelling (HP:0001386)2.28558598
76Gangrene (HP:0100758)2.26348825
77Flat acetabular roof (HP:0003180)2.24441712
78Gout (HP:0001997)2.23376892
79Neonatal onset (HP:0003623)2.21446201
80Nephritis (HP:0000123)2.19152294
81Cerebral edema (HP:0002181)2.17644088
82Thrombophlebitis (HP:0004418)2.16831536
83Asymmetry of the thorax (HP:0001555)2.15783148
84* Epistaxis (HP:0000421)2.12650390
85Malnutrition (HP:0004395)2.12432128
86Small epiphyses (HP:0010585)2.11578937
87Sensorimotor neuropathy (HP:0007141)2.08701557
88Broad alveolar ridges (HP:0000187)2.08306731
89Myositis (HP:0100614)2.06638510
90Pancreatitis (HP:0001733)2.05901575
91Hemorrhage of the eye (HP:0011885)2.04283215
92Enlarged kidneys (HP:0000105)2.02322136
93Late onset (HP:0003584)2.01646391
94Poikilocytosis (HP:0004447)2.01268893
95Hypochromic anemia (HP:0001931)1.97586568
96Opisthotonus (HP:0002179)1.95970254
97Pancreatic islet-cell hyperplasia (HP:0004510)1.94732835
98Brushfield spots (HP:0001088)1.94653880
99Abnormality of the gallbladder (HP:0005264)1.93675021
100Vomiting (HP:0002013)1.93589323
101Hyperinsulinemic hypoglycemia (HP:0000825)1.93121854
102Abnormality of the lumbar spine (HP:0100712)1.90314019
103Generalized aminoaciduria (HP:0002909)1.89646269
104Facial shape deformation (HP:0011334)1.89422447
105Potter facies (HP:0002009)1.89422447
106Abnormality of iron homeostasis (HP:0011031)1.87826698
107Increased serum ferritin (HP:0003281)1.87800266
108Rickets (HP:0002748)1.86369767
109* Menorrhagia (HP:0000132)1.85175624
110Abnormal hand bone ossification (HP:0010660)1.84306563
111* Esophageal varix (HP:0002040)1.84280625
112Abnormality of the nasal septum (HP:0000419)1.83814764
113Abnormality of transition element cation homeostasis (HP:0011030)1.83742716
114Broad palm (HP:0001169)1.83557971
115Arterial thrombosis (HP:0004420)1.83389377
116Turricephaly (HP:0000262)1.82011505
117Abnormal cartilage morphology (HP:0002763)1.81447361
118Abnormal ossification of hand bones (HP:0005921)1.80844984
119Abnormal enzyme/coenzyme activity (HP:0012379)1.80465721
120Hydroxyprolinuria (HP:0003080)1.79829077
121Abnormality of proline metabolism (HP:0010907)1.79829077
122Vaginal fistula (HP:0004320)1.78449391
123Pulmonary embolism (HP:0002204)1.77618022
124Hyperglycemia (HP:0003074)1.76327492
125Widely patent fontanelles and sutures (HP:0004492)1.74582303
126Hypophosphatemic rickets (HP:0004912)1.74080258
127Renal cortical cysts (HP:0000803)1.73012702
128Status epilepticus (HP:0002133)1.72527970
129Abnormality of vitamin metabolism (HP:0100508)1.70551725
130Mucopolysacchariduria (HP:0008155)1.69483040
131Urinary glycosaminoglycan excretion (HP:0003541)1.69483040
132Abnormal foot bone ossification (HP:0010675)1.68940408
133Scanning speech (HP:0002168)1.66349451
134Abnormality of the Achilles tendon (HP:0005109)1.66062292
135Polycythemia (HP:0001901)1.64616220
136Keratoconjunctivitis sicca (HP:0001097)1.62248264
137Epiphyseal dysplasia (HP:0002656)1.61042042
138Flared iliac wings (HP:0002869)1.60611838
139Abnormality of the wing of the ilium (HP:0011867)1.60336019
140Anorexia (HP:0002039)1.59928436
141Elevated alkaline phosphatase (HP:0003155)1.58579672
142Abnormal platelet volume (HP:0011876)1.57536364
143Episodic fever (HP:0001954)1.57274128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.98874170
2ERN14.46403023
3SIK14.46055727
4FGFR44.23108887
5TAOK33.39551818
6MST1R3.18082730
7CDK122.98806504
8INSRR2.94986061
9ERBB42.55915744
10PKN22.23238314
11MAP2K42.16329092
12WNK42.15708451
13FGFR22.04815473
14LATS11.91130234
15WNK11.83979431
16TYK21.81327939
17TRIB31.80328280
18TYRO31.78943683
19DAPK21.73874277
20MAPK111.69067437
21FLT31.68607122
22PIK3CG1.64078190
23CAMK1D1.58450963
24PTK61.56111546
25AKT31.49822254
26RIPK41.47667486
27MAP3K21.46017965
28FGR1.43662188
29SIK21.43524226
30NEK91.38712005
31FRK1.37387182
32MAP3K71.32545305
33EPHB11.28430828
34MET1.27259986
35JAK21.26907032
36JAK11.22947819
37ABL21.22449798
38RIPK11.21777726
39PDGFRA1.18460997
40MAP2K31.18295239
41PRKAA21.13961717
42GRK61.13751317
43KDR1.12483150
44EPHA31.05179816
45MAP3K101.04652795
46TBK11.04405083
47CAMK1G1.03170666
48TGFBR20.96408799
49MAP3K140.95591086
50MAPK40.95045009
51ERBB20.94465569
52KSR20.94383805
53ITK0.90571474
54CSK0.90078352
55IRAK40.84836838
56PRKCZ0.82756381
57TNK20.82732809
58PRPF4B0.82555140
59MAPK120.82516143
60YES10.81722384
61MAP3K30.81554654
62MAP3K110.80639641
63BMX0.79685385
64MATK0.79542282
65TXK0.75838947
66FGFR30.75709570
67SGK10.75315302
68CSF1R0.74749620
69SGK30.73278205
70CDK60.73213016
71CDC42BPA0.72629268
72MAPK150.71582661
73MARK20.70798407
74BRD40.68869140
75PINK10.67456391
76PRKACG0.66996499
77GSK3A0.65644546
78EIF2AK10.65487107
79LCK0.65380356
80JAK30.64863957
81TAOK10.62584228
82SYK0.62127703
83MAPK70.61050159
84PTK20.59055128
85PRKAA10.58708179
86IGF1R0.58629331
87IRAK30.57953448
88CAMKK20.57379563
89FGFR10.56938711
90IKBKE0.56044583
91RPS6KB10.55623049
92PRKCQ0.54342721
93DYRK1B0.52444911
94MAP2K60.51736840
95STK38L0.51693516
96MAP3K130.51012823
97HCK0.50394379
98LYN0.49230659
99RET0.49167296
100FES0.49049211
101NTRK30.48879928
102PDPK10.48750721
103TIE10.47975229
104DDR20.47840160
105CAMK2G0.47374644
106PDGFRB0.46774523
107SGK20.46219975
108CDK40.45649682
109STK380.45632079
110MAP3K60.45373411
111BLK0.45257887
112CAMK40.44978106
113MAP4K10.44800856
114EEF2K0.44664253
115EGFR0.42415167
116MTOR0.40856802
117IRAK10.39014978
118FYN0.38429009
119MAP3K50.38389804
120MAP3K10.34764511
121CSNK1G10.34065877
122PKN10.33218199
123GRK10.32080980
124STK30.31864171
125NLK0.30585864
126PDK10.30170081
127ICK0.29976361
128NUAK10.29858514
129TAOK20.29657822
130PIK3CA0.28596882
131PRKCH0.28369597
132ZAP700.26833759
133CHUK0.26354014
134IRAK20.25380197
135KIT0.25154682
136SGK2230.23649296
137SGK4940.23649296
138ABL10.23626698

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.53707154
2Nitrogen metabolism_Homo sapiens_hsa009103.83061557
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38195098
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37277692
5Arginine biosynthesis_Homo sapiens_hsa002203.07398374
6* Complement and coagulation cascades_Homo sapiens_hsa046103.00513906
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66716543
8Tryptophan metabolism_Homo sapiens_hsa003802.65507094
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53958011
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46530166
11Fatty acid degradation_Homo sapiens_hsa000712.44711335
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31785438
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30454571
14Staphylococcus aureus infection_Homo sapiens_hsa051502.28428178
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09182142
16Butanoate metabolism_Homo sapiens_hsa006502.06516878
17Peroxisome_Homo sapiens_hsa041462.03544399
18Histidine metabolism_Homo sapiens_hsa003401.92896094
19Chemical carcinogenesis_Homo sapiens_hsa052041.90825457
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.90547507
21Caffeine metabolism_Homo sapiens_hsa002321.89361158
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87558921
23Propanoate metabolism_Homo sapiens_hsa006401.86038669
24PPAR signaling pathway_Homo sapiens_hsa033201.85563838
25Fatty acid metabolism_Homo sapiens_hsa012121.76839117
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.75427912
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70819235
28Retinol metabolism_Homo sapiens_hsa008301.70593450
29beta-Alanine metabolism_Homo sapiens_hsa004101.69863579
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62502016
31Selenocompound metabolism_Homo sapiens_hsa004501.54421944
32Phenylalanine metabolism_Homo sapiens_hsa003601.53452555
33Bile secretion_Homo sapiens_hsa049761.51242017
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47033341
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41554112
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40294891
37Tyrosine metabolism_Homo sapiens_hsa003501.39722330
38Starch and sucrose metabolism_Homo sapiens_hsa005001.32176540
39Pyruvate metabolism_Homo sapiens_hsa006201.28798860
40ABC transporters_Homo sapiens_hsa020101.28405262
41Sulfur metabolism_Homo sapiens_hsa009201.26191806
42Fatty acid elongation_Homo sapiens_hsa000621.25800642
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.22931662
44Folate biosynthesis_Homo sapiens_hsa007901.17052019
45Steroid biosynthesis_Homo sapiens_hsa001001.14967702
46Biosynthesis of amino acids_Homo sapiens_hsa012301.13319162
47Fat digestion and absorption_Homo sapiens_hsa049751.13106874
48Carbon metabolism_Homo sapiens_hsa012001.04580770
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95154336
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.95069687
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93300445
52Arginine and proline metabolism_Homo sapiens_hsa003300.89741473
53Vitamin digestion and absorption_Homo sapiens_hsa049770.89690809
54Lysine degradation_Homo sapiens_hsa003100.89004553
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.87055741
56Sulfur relay system_Homo sapiens_hsa041220.86696764
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86129097
58Vitamin B6 metabolism_Homo sapiens_hsa007500.85292112
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80088016
60One carbon pool by folate_Homo sapiens_hsa006700.69662801
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65302877
62Glycerolipid metabolism_Homo sapiens_hsa005610.64785353
63Glutathione metabolism_Homo sapiens_hsa004800.57620448
64Pentose phosphate pathway_Homo sapiens_hsa000300.53784771
65Fatty acid biosynthesis_Homo sapiens_hsa000610.52327053
66Prion diseases_Homo sapiens_hsa050200.46290611
67Metabolic pathways_Homo sapiens_hsa011000.41446138
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39283964
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34652052
70Insulin resistance_Homo sapiens_hsa049310.27968055
71Linoleic acid metabolism_Homo sapiens_hsa005910.27938481
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.26746548
73Galactose metabolism_Homo sapiens_hsa000520.24339645
74Non-small cell lung cancer_Homo sapiens_hsa052230.19777157
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18373780
76N-Glycan biosynthesis_Homo sapiens_hsa005100.18137648
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18063011
78Fructose and mannose metabolism_Homo sapiens_hsa000510.17854509
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.13271183
80Leishmaniasis_Homo sapiens_hsa051400.12165975
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.11977399
82Glucagon signaling pathway_Homo sapiens_hsa049220.10387948
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09602926
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.08461327
85Osteoclast differentiation_Homo sapiens_hsa043800.06857867
86Mineral absorption_Homo sapiens_hsa049780.05778357
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.05745587
88AMPK signaling pathway_Homo sapiens_hsa041520.03203141
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.01804493
90FoxO signaling pathway_Homo sapiens_hsa040680.00932932
91HIF-1 signaling pathway_Homo sapiens_hsa040660.00462672
92Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2067214
93Malaria_Homo sapiens_hsa05144-0.1970607
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1962173
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1952587
96Lysosome_Homo sapiens_hsa04142-0.1925957
97Regulation of autophagy_Homo sapiens_hsa04140-0.1703049
98African trypanosomiasis_Homo sapiens_hsa05143-0.1525579
99Hepatitis C_Homo sapiens_hsa05160-0.1442085
100Amoebiasis_Homo sapiens_hsa05146-0.1279648
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1261636
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1139196
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1050778
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1020659
105Other glycan degradation_Homo sapiens_hsa00511-0.0948227
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0884300
107Insulin signaling pathway_Homo sapiens_hsa04910-0.0876502
108Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0656084
109Pertussis_Homo sapiens_hsa05133-0.0609220
110Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0560714
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0378579
112Platelet activation_Homo sapiens_hsa04611-0.0190683
113Measles_Homo sapiens_hsa05162-0.0163213
114Circadian rhythm_Homo sapiens_hsa04710-0.0132450

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