F3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.72314136
2keratinocyte proliferation (GO:0043616)5.89180165
3cell-substrate junction assembly (GO:0007044)5.84927836
4mesodermal cell differentiation (GO:0048333)5.35024891
5regulation of tight junction assembly (GO:2000810)5.33741352
6negative regulation of keratinocyte proliferation (GO:0010839)5.23675991
7adenine nucleotide transport (GO:0051503)4.89330278
8purine ribonucleotide transport (GO:0015868)4.64173334
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.60631861
10L-serine transport (GO:0015825)4.60250261
11hypotonic response (GO:0006971)4.45514597
12regulation of glomerular filtration (GO:0003093)4.37708486
13alanine transport (GO:0032328)4.26746064
14regulation of metalloenzyme activity (GO:0048552)4.15609929
15regulation of keratinocyte proliferation (GO:0010837)4.07648858
16purine nucleotide transport (GO:0015865)4.04849505
17gap junction assembly (GO:0016264)4.04282913
18serine transport (GO:0032329)3.91921403
19protein localization to endosome (GO:0036010)3.91331586
20diterpenoid biosynthetic process (GO:0016102)3.90871686
21hemidesmosome assembly (GO:0031581)3.86825629
22renal system process involved in regulation of blood volume (GO:0001977)3.85838418
23membrane raft organization (GO:0031579)3.85590706
24positive regulation of cellular amide metabolic process (GO:0034250)3.73827011
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.68444543
26dermatan sulfate biosynthetic process (GO:0030208)3.65574276
27negative regulation of astrocyte differentiation (GO:0048712)3.64503284
28one-carbon compound transport (GO:0019755)3.62568709
29chondrocyte proliferation (GO:0035988)3.61905423
30branching involved in salivary gland morphogenesis (GO:0060445)3.58575609
31renal absorption (GO:0070293)3.55741274
32wound healing, spreading of epidermal cells (GO:0035313)3.54700840
33dermatan sulfate metabolic process (GO:0030205)3.53703104
34wound healing, spreading of cells (GO:0044319)3.50224850
35positive regulation of osteoblast proliferation (GO:0033690)3.44474889
36cell communication by electrical coupling (GO:0010644)3.44406224
37muscle cell migration (GO:0014812)3.40879329
38regulation of water loss via skin (GO:0033561)3.40302532
39substrate-dependent cell migration (GO:0006929)3.34762741
40negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.33638958
41renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.32561019
42establishment of skin barrier (GO:0061436)3.31682747
43ovulation cycle (GO:0042698)3.29266069
44G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.24142376
45hormone catabolic process (GO:0042447)3.23237197
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22576356
47regulation of phospholipase A2 activity (GO:0032429)3.21853270
48regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.18672430
49establishment of tissue polarity (GO:0007164)3.18514167
50establishment of planar polarity (GO:0001736)3.18514167
51negative regulation of heart growth (GO:0061117)3.18402281
52negative regulation of cardiac muscle tissue growth (GO:0055022)3.18402281
53regulation of transforming growth factor beta1 production (GO:0032908)3.15225556
54lung vasculature development (GO:0060426)3.12068783
55collagen fibril organization (GO:0030199)3.09144368
56atrial cardiac muscle cell action potential (GO:0086014)3.08531525
57glial cell proliferation (GO:0014009)3.08360388
58cellular response to vitamin (GO:0071295)3.06788640
59chemical homeostasis within a tissue (GO:0048875)3.06667614
60chronic inflammatory response (GO:0002544)3.05523323
61Golgi transport vesicle coating (GO:0048200)3.02919689
62COPI coating of Golgi vesicle (GO:0048205)3.02919689
63cellular response to vitamin D (GO:0071305)3.01730251
64wound healing (GO:0042060)3.01642320
65mammary gland epithelial cell proliferation (GO:0033598)3.01232075
66smooth muscle tissue development (GO:0048745)2.99696061
67skin morphogenesis (GO:0043589)2.97950679
68keratinocyte development (GO:0003334)2.97364219
69type B pancreatic cell proliferation (GO:0044342)2.97009828
70regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.96781168
71lens fiber cell development (GO:0070307)2.96230013
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96162534
73endodermal cell differentiation (GO:0035987)2.95538876
74negative regulation of anoikis (GO:2000811)2.95330674
75positive regulation of hair cycle (GO:0042635)2.94689103
76positive regulation of hair follicle development (GO:0051798)2.94689103
77negative regulation of stem cell proliferation (GO:2000647)2.94216516
78cell junction assembly (GO:0034329)2.93775865
79negative regulation of fatty acid transport (GO:2000192)2.93650807
80atrioventricular valve morphogenesis (GO:0003181)2.92609630
81extracellular matrix disassembly (GO:0022617)2.91420348
82regulation of hair follicle development (GO:0051797)2.88077684
83protein retention in ER lumen (GO:0006621)2.82436672
84positive regulation of epidermis development (GO:0045684)2.82435205
85amino acid import (GO:0043090)2.80668231
86response to gravity (GO:0009629)2.80626283
87low-density lipoprotein particle remodeling (GO:0034374)2.79875052
88extracellular matrix assembly (GO:0085029)2.77885700
89regulation of astrocyte differentiation (GO:0048710)2.77498511
90blood vessel maturation (GO:0001955)2.76118382
91polarized epithelial cell differentiation (GO:0030859)2.76056731
92epidermis development (GO:0008544)2.75933741
93regulation of vitamin D biosynthetic process (GO:0060556)2.75789286
94cell junction organization (GO:0034330)2.75500892
95positive regulation of extracellular matrix organization (GO:1903055)2.75350123
96chondroitin sulfate catabolic process (GO:0030207)2.75159518
97negative regulation of catenin import into nucleus (GO:0035414)2.75055759
98negative regulation of cartilage development (GO:0061037)2.74599727
99regulation of osteoblast proliferation (GO:0033688)2.74202179
100apoptotic cell clearance (GO:0043277)2.74147744
101cellular copper ion homeostasis (GO:0006878)2.73763276
102negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73427419
103peptidyl-proline hydroxylation (GO:0019511)2.73213037
104mesenchymal-epithelial cell signaling (GO:0060638)2.72688808
105terpenoid biosynthetic process (GO:0016114)2.72638292
106endothelium development (GO:0003158)2.72480588
107negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.71368747
108cell-substrate adherens junction assembly (GO:0007045)2.69790384
109focal adhesion assembly (GO:0048041)2.69790384
110chondroitin sulfate biosynthetic process (GO:0030206)2.68643917
111renal filtration (GO:0097205)2.68382862
112retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67894577
113intermediate filament organization (GO:0045109)2.67759925
114regulation of transforming growth factor beta2 production (GO:0032909)2.67315446
115regulation of integrin-mediated signaling pathway (GO:2001044)2.66821761
116gland morphogenesis (GO:0022612)2.66776863
117positive regulation of endothelial cell apoptotic process (GO:2000353)2.63703741
118positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62424893
119epithelial cell maturation (GO:0002070)2.62056809
120lateral sprouting from an epithelium (GO:0060601)2.61588490
121negative regulation of complement activation (GO:0045916)2.61062040
122regulation of transforming growth factor beta production (GO:0071634)2.59683910
123cellular potassium ion homeostasis (GO:0030007)2.59090301
124regulation of anoikis (GO:2000209)2.58884311
125cell adhesion mediated by integrin (GO:0033627)2.58717987
126virion attachment to host cell (GO:0019062)2.58383286
127keratinocyte differentiation (GO:0030216)2.57727082
128lung lobe morphogenesis (GO:0060463)2.57598347
129positive regulation of monocyte chemotaxis (GO:0090026)2.57544276
130positive regulation of cartilage development (GO:0061036)2.56619569
131epithelial cell-cell adhesion (GO:0090136)2.56159834
132sequestering of extracellular ligand from receptor (GO:0035581)2.55384420
133cellular response to cholesterol (GO:0071397)2.54209756
134nucleotide-sugar biosynthetic process (GO:0009226)2.53848145
135regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.53844023
136C4-dicarboxylate transport (GO:0015740)2.53524173
137regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.51887640
138regulation of vitamin metabolic process (GO:0030656)2.51868003
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.50246417
140heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.49782398
141negative regulation of leukocyte chemotaxis (GO:0002689)2.49451953
142positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.49203670
143negative regulation of response to reactive oxygen species (GO:1901032)2.49160488
144UDP-N-acetylglucosamine metabolic process (GO:0006047)2.48889186
145negative regulation of chondrocyte differentiation (GO:0032331)2.48573847
146decidualization (GO:0046697)2.48562066
147protein hydroxylation (GO:0018126)2.47985303
148nucleotide transport (GO:0006862)2.47380824
149substrate adhesion-dependent cell spreading (GO:0034446)2.46308685
150positive regulation of epidermal cell differentiation (GO:0045606)2.45487871
151positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45421032
152COPII vesicle coating (GO:0048208)2.44773291
153linoleic acid metabolic process (GO:0043651)2.44048138
154regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.43918975
155positive regulation of astrocyte differentiation (GO:0048711)2.43785128
156cytoskeletal anchoring at plasma membrane (GO:0007016)2.43170775
157cell aggregation (GO:0098743)2.41527088
158cartilage condensation (GO:0001502)2.41527088
159peripheral nervous system axon ensheathment (GO:0032292)2.40904384
160myelination in peripheral nervous system (GO:0022011)2.40904384
161adherens junction assembly (GO:0034333)2.38674103
162regulation of monocyte chemotaxis (GO:0090025)2.34707297
163regulation of skeletal muscle contraction (GO:0014819)2.34023009
164regulation of hydrogen peroxide-induced cell death (GO:1903205)2.33842114
165somatic stem cell division (GO:0048103)2.32691331
166basement membrane organization (GO:0071711)2.31995311
167surfactant homeostasis (GO:0043129)2.31274203
168endothelial cell morphogenesis (GO:0001886)2.30853263
169positive regulation of triglyceride biosynthetic process (GO:0010867)2.30599503
170multicellular organismal water homeostasis (GO:0050891)2.30540616
171sodium ion export (GO:0071436)2.30359752
172positive regulation of p38MAPK cascade (GO:1900745)2.30288617
173regulation of beta-amyloid formation (GO:1902003)2.30000685
174xenobiotic catabolic process (GO:0042178)2.26522680
175regulation of membrane protein ectodomain proteolysis (GO:0051043)2.25558903
176adhesion of symbiont to host cell (GO:0044650)2.25270345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.25879399
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.13295174
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.76833962
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.70114982
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.28819105
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.73078338
7CLOCK_20551151_ChIP-Seq_293T_Human2.50071797
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.38631222
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.32384960
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21117163
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.13937980
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09337627
13* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94555631
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94405197
15CJUN_26792858_Chip-Seq_BT549_Human1.86982620
16TP53_18474530_ChIP-ChIP_U2OS_Human1.85687045
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.81029327
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80883433
19RXR_22108803_ChIP-Seq_LS180_Human1.80371836
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80207914
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.80166858
22* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78263357
23* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.77489304
24* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.77489304
25AR_21572438_ChIP-Seq_LNCaP_Human1.75569441
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74408571
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68897563
28TP53_16413492_ChIP-PET_HCT116_Human1.62066916
29* UBF1/2_26484160_Chip-Seq_HMECs_Human1.61307463
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60425806
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60368723
32* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59552830
33* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58555406
34* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58555406
35* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58483748
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.58429581
37ATF3_27146783_Chip-Seq_COLON_Human1.55382884
38* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54396373
39* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.54270993
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51423421
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49696614
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.48806991
43SOX2_20726797_ChIP-Seq_SW620_Human1.47359544
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46247973
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46068730
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44812064
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44812064
48* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42725523
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41283470
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40528303
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38520460
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35073659
53* FOXO3_23340844_ChIP-Seq_DLD1_Human1.35055151
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.34182118
55ZNF263_19887448_ChIP-Seq_K562_Human1.33848696
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.32764918
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32678312
58* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32192087
59AR_21909140_ChIP-Seq_LNCAP_Human1.31335307
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30789088
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27794976
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25945833
63KLF5_25053715_ChIP-Seq_YYC3_Human1.25189348
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22834494
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.22722746
66* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21321431
67AHR_22903824_ChIP-Seq_MCF-7_Human1.20238249
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19964642
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19178281
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17783906
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17110284
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.16908812
73* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16738459
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14721824
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.14147119
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12735721
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11679302
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11615433
79* TP63_23658742_ChIP-Seq_EP156T_Human1.11203512
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09379325
81TP53_22127205_ChIP-Seq_IMR90_Human1.09012643
82* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06633877
83* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06321917
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05850399
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04945317
86* GATA4_25053715_ChIP-Seq_YYC3_Human1.04931649
87* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04242697
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04070658
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02808703
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.00723116
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.00651085
92* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99395562
93BCAT_22108803_ChIP-Seq_LS180_Human0.98971380
94* TBX20_22080862_ChIP-Seq_HEART_Mouse0.98158946
95* TBX20_22328084_ChIP-Seq_HEART_Mouse0.98158946
96BRD4_25478319_ChIP-Seq_HGPS_Human0.97291639
97EGR1_19374776_ChIP-ChIP_THP-1_Human0.96524273
98EZH2_27304074_Chip-Seq_ESCs_Mouse0.95886220
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94013868
100CDX2_20551321_ChIP-Seq_CACO-2_Human0.93738964
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93081006
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92841210
103IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92110372
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92069361
105RING1B_27294783_Chip-Seq_ESCs_Mouse0.91172304
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90623357
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90559942
108* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89446746
109GATA3_24758297_ChIP-Seq_MCF-7_Human0.88876157
110JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87310837
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.87195468
112DROSHA_22980978_ChIP-Seq_HELA_Human0.86960543
113CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86586234
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86557631
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86176047
116SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86106781
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86090967
118* EZH2_27294783_Chip-Seq_ESCs_Mouse0.84622878
119* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84464225
120RACK7_27058665_Chip-Seq_MCF-7_Human0.84356942
121* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.84242567
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84077776
123GATA6_25053715_ChIP-Seq_YYC3_Human0.83534200
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83421280
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.83292070
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83142333
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82855565
128* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81443479
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.75571127
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75130912
131* TP63_22573176_ChIP-Seq_HFKS_Human0.74916135
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.70272800
133TET1_21490601_ChIP-Seq_MESCs_Mouse0.69780915
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68454078
135MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.67924852
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67913478
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.66584714
138ELK1_22589737_ChIP-Seq_MCF10A_Human0.66020958
139NANOG_18692474_ChIP-Seq_MEFs_Mouse0.64923219
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.64655108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.16446100
2MP0009384_cardiac_valve_regurgitation5.12282738
3MP0003279_aneurysm4.39770981
4MP0008438_abnormal_cutaneous_collagen4.33562119
5MP0010234_abnormal_vibrissa_follicle3.85285121
6MP0009780_abnormal_chondrocyte_physiolo3.37698601
7MP0000566_synostosis3.18223060
8MP0001958_emphysema3.09807508
9MP0010030_abnormal_orbit_morphology2.96964249
10MP0005275_abnormal_skin_tensile2.93908376
11MP0003705_abnormal_hypodermis_morpholog2.83223140
12MP0004272_abnormal_basement_membrane2.77525754
13MP0010678_abnormal_skin_adnexa2.43382393
14MP0003566_abnormal_cell_adhesion2.30532762
15MP0001216_abnormal_epidermal_layer2.25062610
16MP0003941_abnormal_skin_development2.18142287
17MP0004858_abnormal_nervous_system2.17389120
18MP0003329_amyloid_beta_deposits2.09224776
19MP0003690_abnormal_glial_cell2.02662271
20MP0001542_abnormal_bone_strength1.98402853
21MP0002234_abnormal_pharynx_morphology1.98106737
22MP0001346_abnormal_lacrimal_gland1.94663346
23MP0005646_abnormal_pituitary_gland1.87222432
24MP0001849_ear_inflammation1.86520260
25MP0005508_abnormal_skeleton_morphology1.85287703
26MP0005503_abnormal_tendon_morphology1.83379095
27MP0000049_abnormal_middle_ear1.76287175
28MP0005623_abnormal_meninges_morphology1.65183106
29MP0002877_abnormal_melanocyte_morpholog1.64949699
30MP0006054_spinal_hemorrhage1.62701482
31MP0002060_abnormal_skin_morphology1.62252007
32MP0003191_abnormal_cellular_cholesterol1.61363131
33MP0005377_hearing/vestibular/ear_phenot1.56484773
34MP0003878_abnormal_ear_physiology1.56484773
35MP0003091_abnormal_cell_migration1.53383604
36MP0002796_impaired_skin_barrier1.53076306
37MP0005409_darkened_coat_color1.51731632
38MP0001853_heart_inflammation1.51641872
39MP0000762_abnormal_tongue_morphology1.47938267
40MP0002295_abnormal_pulmonary_circulatio1.46348544
41MP0009250_abnormal_appendicular_skeleto1.41905912
42MP0005023_abnormal_wound_healing1.33215199
43MP0003136_yellow_coat_color1.31843123
44MP0004264_abnormal_extraembryonic_tissu1.31612723
45MP0000604_amyloidosis1.30464085
46MP0000428_abnormal_craniofacial_morphol1.28683277
47MP0001299_abnormal_eye_distance/1.27118135
48MP0001879_abnormal_lymphatic_vessel1.22993433
49MP0005360_urolithiasis1.22580758
50MP0003075_altered_response_to1.21395391
51MP0000858_altered_metastatic_potential1.20114217
52MP0005171_absent_coat_pigmentation1.12364079
53MP0000750_abnormal_muscle_regeneration1.12194689
54MP0000537_abnormal_urethra_morphology1.12157961
55MP0000163_abnormal_cartilage_morphology1.11391976
56MP0005248_abnormal_Harderian_gland1.11332802
57MP0000377_abnormal_hair_follicle1.08909505
58* MP0005164_abnormal_response_to1.05098894
59MP0001177_atelectasis1.04262234
60MP0000681_abnormal_thyroid_gland1.03157684
61MP0002896_abnormal_bone_mineralization1.03032698
62MP0004947_skin_inflammation1.02467500
63MP0002089_abnormal_postnatal_growth/wei1.02242653
64MP0001881_abnormal_mammary_gland1.00342226
65MP0003448_altered_tumor_morphology0.98275674
66MP0000647_abnormal_sebaceous_gland0.94927271
67MP0005670_abnormal_white_adipose0.94352179
68MP0003115_abnormal_respiratory_system0.93873819
69MP0001243_abnormal_dermal_layer0.93553939
70MP0002998_abnormal_bone_remodeling0.93151162
71MP0002249_abnormal_larynx_morphology0.92700488
72MP0004885_abnormal_endolymph0.92081416
73MP0004782_abnormal_surfactant_physiolog0.91831862
74MP0008260_abnormal_autophagy0.91791134
75MP0005390_skeleton_phenotype0.90511936
76MP0004019_abnormal_vitamin_homeostasis0.89502992
77MP0003942_abnormal_urinary_system0.89256470
78MP0002332_abnormal_exercise_endurance0.89159949
79MP0000427_abnormal_hair_cycle0.88660856
80MP0000534_abnormal_ureter_morphology0.87809278
81MP0003315_abnormal_perineum_morphology0.86892672
82MP0002115_abnormal_skeleton_extremities0.86697599
83MP0002177_abnormal_outer_ear0.86660653
84MP0003011_delayed_dark_adaptation0.86153005
85MP0000467_abnormal_esophagus_morphology0.85383807
86MP0000003_abnormal_adipose_tissue0.84806148
87MP0009840_abnormal_foam_cell0.84789605
88MP0000013_abnormal_adipose_tissue0.84135602
89MP0001502_abnormal_circadian_rhythm0.83854089
90MP0000538_abnormal_urinary_bladder0.83613790
91MP0010368_abnormal_lymphatic_system0.83580680
92MP0003755_abnormal_palate_morphology0.83405705
93MP0003183_abnormal_peptide_metabolism0.83024244
94MP0008004_abnormal_stomach_pH0.81691267
95MP0000767_abnormal_smooth_muscle0.81521658
96MP0000613_abnormal_salivary_gland0.80539794
97MP0005388_respiratory_system_phenotype0.80523166
98MP0002133_abnormal_respiratory_system0.80523166
99* MP0005595_abnormal_vascular_smooth0.80106493
100MP0001348_abnormal_lacrimal_gland0.79894070
101MP0005501_abnormal_skin_physiology0.79112749
102MP0003937_abnormal_limbs/digits/tail_de0.78873085
103MP0002098_abnormal_vibrissa_morphology0.78389223
104MP0005165_increased_susceptibility_to0.78203372
105MP0000579_abnormal_nail_morphology0.77950655
106MP0005193_abnormal_anterior_eye0.77779106
107* MP0009931_abnormal_skin_appearance0.76240354
108MP0010771_integument_phenotype0.76149078
109MP0002282_abnormal_trachea_morphology0.74613125
110MP0000627_abnormal_mammary_gland0.74582721
111MP0003300_gastrointestinal_ulcer0.73792974
112MP0003828_pulmonary_edema0.73194040
113MP0010352_gastrointestinal_tract_polyps0.73144935
114MP0002116_abnormal_craniofacial_bone0.73113642
115MP0003045_fibrosis0.72914294
116MP0000678_abnormal_parathyroid_gland0.72768779
117MP0005197_abnormal_uvea_morphology0.72094346
118MP0000462_abnormal_digestive_system0.71671799
119MP0001191_abnormal_skin_condition0.71429994
120MP0009053_abnormal_anal_canal0.70749721
121MP0003453_abnormal_keratinocyte_physiol0.70393701
122MP0000383_abnormal_hair_follicle0.70268760
123MP0002233_abnormal_nose_morphology0.69382011
124* MP0004883_abnormal_blood_vessel0.69265022
125MP0001270_distended_abdomen0.68731470
126MP0005166_decreased_susceptibility_to0.68389073
127MP0003950_abnormal_plasma_membrane0.68291754
128MP0000733_abnormal_muscle_development0.67723832
129MP0002090_abnormal_vision0.67191722
130MP0000432_abnormal_head_morphology0.66884337
131MP0002113_abnormal_skeleton_development0.66762422
132MP0001340_abnormal_eyelid_morphology0.66681343
133MP0003634_abnormal_glial_cell0.66615454
134MP0002109_abnormal_limb_morphology0.65944261
135MP0005257_abnormal_intraocular_pressure0.65621637
136MP0000367_abnormal_coat/_hair0.64155952
137MP0001851_eye_inflammation0.60597030
138MP0005375_adipose_tissue_phenotype0.56498383
139MP0000751_myopathy0.56054021
140MP0002168_other_aberrant_phenotype0.55697033

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the phalanges of the hand (HP:0009802)7.07458712
2Aplasia involving bones of the extremities (HP:0009825)7.07458712
3Aplasia involving bones of the upper limbs (HP:0009823)7.07458712
4Plantar hyperkeratosis (HP:0007556)6.02750742
5Thick nail (HP:0001805)5.45199663
6Premature rupture of membranes (HP:0001788)4.82242287
7Nail dystrophy (HP:0008404)4.48933126
8Palmoplantar hyperkeratosis (HP:0000972)4.27805892
9Protrusio acetabuli (HP:0003179)4.16593183
10Onycholysis (HP:0001806)4.15484580
11Palmar hyperkeratosis (HP:0010765)4.04197524
12Ridged nail (HP:0001807)3.84606289
13Vascular tortuosity (HP:0004948)3.81759189
14Short hallux (HP:0010109)3.74529548
15Arterial tortuosity (HP:0005116)3.72239829
16Atrophic scars (HP:0001075)3.53642837
17Tetraparesis (HP:0002273)3.45963475
18Aortic dissection (HP:0002647)3.45953398
19Short middle phalanx of the 5th finger (HP:0004220)3.44495968
20Aplasia/Hypoplasia of the hallux (HP:0008362)3.42420347
21Natal tooth (HP:0000695)3.38812117
22Abnormal blistering of the skin (HP:0008066)3.38314216
23Mixed hearing impairment (HP:0000410)3.30503000
24Neonatal short-limb short stature (HP:0008921)3.23719763
25Pterygium (HP:0001059)3.22931322
26Shallow orbits (HP:0000586)3.09177430
27Humeroradial synostosis (HP:0003041)3.02584722
28Synostosis involving the elbow (HP:0003938)3.02584722
29Selective tooth agenesis (HP:0001592)2.94813602
30Ankyloglossia (HP:0010296)2.88859867
31Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.86828699
32Pili torti (HP:0003777)2.86469937
33Megalencephaly (HP:0001355)2.84237912
34Broad metatarsal (HP:0001783)2.83337241
35Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.78303050
36Long nose (HP:0003189)2.76585331
37Hypoplastic left heart (HP:0004383)2.73762299
38Aortic aneurysm (HP:0004942)2.71797693
39Abnormality of the middle phalanges of the toes (HP:0010183)2.69965110
40Cardiovascular calcification (HP:0011915)2.68537538
41Follicular hyperkeratosis (HP:0007502)2.68156552
42Cervical subluxation (HP:0003308)2.66788318
43Fragile nails (HP:0001808)2.66192478
44Vascular calcification (HP:0004934)2.65604993
45Abnormality of dentin (HP:0010299)2.61901984
46Fragile skin (HP:0001030)2.61742661
47Abnormality of oral frenula (HP:0000190)2.55873950
48Spondylolisthesis (HP:0003302)2.54144402
49Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.53708896
50Abnormal hair laboratory examination (HP:0003328)2.52378179
51Bronchomalacia (HP:0002780)2.51631374
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.50955632
53Osteolytic defects of the hand bones (HP:0009699)2.50955632
54Abnormality of the phalanges of the 5th finger (HP:0004213)2.48766897
55Popliteal pterygium (HP:0009756)2.46421730
56Short nail (HP:0001799)2.45823887
57Tarsal synostosis (HP:0008368)2.44828936
58Abnormality of the dental pulp (HP:0006479)2.42728445
59Sparse eyelashes (HP:0000653)2.42084701
60Abnormality of molar morphology (HP:0011070)2.41446024
61Abnormality of molar (HP:0011077)2.41446024
62Hypoplastic labia majora (HP:0000059)2.40341905
63Soft skin (HP:0000977)2.37612998
64Fibular aplasia (HP:0002990)2.34852635
65Amniotic constriction ring (HP:0009775)2.31775933
66Abnormality of placental membranes (HP:0011409)2.31775933
67Dilatation of the ascending aorta (HP:0005111)2.29468098
68Abnormality of the dental root (HP:0006486)2.27181727
69Taurodontia (HP:0000679)2.27181727
70Abnormality of permanent molar morphology (HP:0011071)2.27181727
71Synostosis involving bones of the feet (HP:0009140)2.24448306
72Synostosis involving bones of the lower limbs (HP:0009138)2.24448306
73Cerebral aneurysm (HP:0004944)2.24083692
74Narrow nasal bridge (HP:0000446)2.23204217
75Abnormality of the axillary hair (HP:0100134)2.23076453
76Abnormality of secondary sexual hair (HP:0009888)2.23076453
77Dry hair (HP:0011359)2.22867994
78Craniofacial hyperostosis (HP:0004493)2.22156839
79Advanced eruption of teeth (HP:0006288)2.21715728
80Aplasia cutis congenita (HP:0001057)2.20960086
81Lip pit (HP:0100267)2.17648468
82Alopecia of scalp (HP:0002293)2.15580754
83Right ventricular cardiomyopathy (HP:0011663)2.15363530
84Oligodontia (HP:0000677)2.14242896
85Broad face (HP:0000283)2.13614636
86Absent toe (HP:0010760)2.13514843
87Ankle contracture (HP:0006466)2.13270514
88Wormian bones (HP:0002645)2.12463317
89Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.11784914
90Bladder diverticulum (HP:0000015)2.11172013
91Hydroureter (HP:0000072)2.10932400
92Abnormality of the labia majora (HP:0012881)2.09763679
93Femoral bowing (HP:0002980)2.09099536
94Split foot (HP:0001839)2.07530787
95Hypodontia (HP:0000668)2.06686664
96Ulnar bowing (HP:0003031)2.06512332
97Hypotrichosis (HP:0001006)2.06245333
98Bowed forearm bones (HP:0003956)2.04433501
99Bowing of the arm (HP:0006488)2.04433501
100Bell-shaped thorax (HP:0001591)2.04245472
101Back pain (HP:0003418)2.02699637
102Abnormality of the distal phalanges of the toes (HP:0010182)2.01316202
103Hypoplastic heart (HP:0001961)2.00238374
104Abnormality of the phalanges of the 2nd finger (HP:0009541)1.99846999
105Trismus (HP:0000211)1.98839689
106Coronal craniosynostosis (HP:0004440)1.98593080
107Neurofibrillary tangles (HP:0002185)1.96647002
108Peritonitis (HP:0002586)1.95743900
109Xerostomia (HP:0000217)1.94623770
110Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.94487126
111Hoarse voice (HP:0001609)1.94378658
112Milia (HP:0001056)1.93660981
113Hypoalphalipoproteinemia (HP:0003233)1.92658593
114Corneal dystrophy (HP:0001131)1.92596078
115Axonal loss (HP:0003447)1.92361862
116Abnormality of nail color (HP:0100643)1.91537979
117Hypoplasia of dental enamel (HP:0006297)1.91485414
118Tibial bowing (HP:0002982)1.89884858
119Abnormality of the middle phalanges of the hand (HP:0009833)1.89057306
120Biconcave vertebral bodies (HP:0004586)1.88768142
121Median cleft lip (HP:0000161)1.88745727
122Reduced subcutaneous adipose tissue (HP:0003758)1.88526001
123Atrioventricular block (HP:0001678)1.87905082
124Abnormality of proline metabolism (HP:0010907)1.87003800
125Hydroxyprolinuria (HP:0003080)1.87003800
126Elbow flexion contracture (HP:0002987)1.86766165
127Stomach cancer (HP:0012126)1.85985522
128Sparse scalp hair (HP:0002209)1.83988873
129Absent eyelashes (HP:0000561)1.83909987
130Radial bowing (HP:0002986)1.83221901
131Broad long bones (HP:0005622)1.82730672
132Glucose intolerance (HP:0000833)1.82570296
133Short middle phalanx of finger (HP:0005819)1.82402538
134Woolly hair (HP:0002224)1.82280374
135Cranial hyperostosis (HP:0004437)1.81327334
136Vertebral compression fractures (HP:0002953)1.80809258
137Corneal erosion (HP:0200020)1.80779076
138Turricephaly (HP:0000262)1.80632326
139Abnormality of the proximal phalanges of the hand (HP:0009834)1.79287009
140Hyperhidrosis (HP:0000975)1.79102102
141Anonychia (HP:0001798)1.79051334
142Hypoplastic scapulae (HP:0000882)1.78883519
143Aplasia/Hypoplasia of the scapulae (HP:0006713)1.78883519
144Cheilitis (HP:0100825)1.78857634
145Cutaneous syndactyly (HP:0012725)1.78688372
146Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.78665015
147Blue sclerae (HP:0000592)1.78400940
148Carious teeth (HP:0000670)1.76918602
149Spinal rigidity (HP:0003306)1.75474252
150Periodontitis (HP:0000704)1.75209561
151Fatigable weakness (HP:0003473)1.74827339
152Abnormality of the neuromuscular junction (HP:0003398)1.74827339
153Erythema (HP:0010783)1.70648545
154Acanthosis nigricans (HP:0000956)1.68458385
155Interstitial pulmonary disease (HP:0006530)1.68162219
156Knee flexion contracture (HP:0006380)1.67367337
157Cerebral inclusion bodies (HP:0100314)1.66978891
158Neonatal death (HP:0003811)1.66633599
159Palmoplantar keratoderma (HP:0000982)1.65387107
160Oral leukoplakia (HP:0002745)1.64686077
161Abnormalities of placenta or umbilical cord (HP:0001194)1.64240573
162Focal segmental glomerulosclerosis (HP:0000097)1.61401605
163Mildly elevated creatine phosphokinase (HP:0008180)1.60239609
164Distal upper limb amyotrophy (HP:0007149)1.58097178
165Upper limb amyotrophy (HP:0009129)1.58097178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.44240771
2TRIB32.91554977
3MAP3K92.78491190
4DDR22.76345418
5LMTK22.69498641
6SIK12.62531824
7ARAF2.52750135
8MAP3K32.51698911
9STK242.35738217
10EPHB22.12736622
11MAP3K122.12600305
12TAOK22.11251650
13PTK21.98357014
14LATS21.92214138
15TTN1.90542353
16NEK61.89694102
17FER1.88776305
18LATS11.88638583
19TESK11.83368152
20GRK71.78495841
21PHKG21.77587035
22PHKG11.77587035
23ERN11.72441874
24FLT31.71177251
25PRKD31.67431209
26PDK21.64343104
27ERBB31.59745794
28PIM21.59686363
29PIK3CA1.59274832
30MST41.58850241
31EPHA31.56484258
32RIPK11.56411224
33MAPK71.54856238
34TRPM71.53764179
35MUSK1.51275253
36PDGFRA1.50307695
37PAK31.49257670
38MAP3K21.44033638
39LIMK11.42606339
40EPHB11.40350334
41STK38L1.38323666
42BMX1.35877818
43MAPK121.35703829
44MET1.34446120
45FGFR11.33802950
46EPHA41.29977457
47FGFR21.28498387
48TNIK1.28287607
49ERBB41.23543285
50IRAK31.19985674
51MST1R1.15043778
52PRKCE1.08837705
53MAPK151.08035028
54TGFBR21.07102277
55PTK61.04042031
56TAOK11.03023879
57DMPK0.99238933
58TGFBR10.96459982
59ABL20.96270425
60ROCK10.96265431
61MAP3K130.88459179
62CDK80.87425269
63SGK20.86541396
64MAP2K10.83275222
65BCR0.80692614
66PDGFRB0.80343665
67SGK30.78908067
68KSR10.78767257
69CDK60.78739259
70PBK0.77598154
71MYLK0.77199375
72PAK20.75280682
73PTK2B0.75139321
74STK100.74736084
75IGF1R0.72427085
76MOS0.71027249
77RPS6KB20.68359537
78GRK50.64610119
79PIK3CG0.64402183
80CDC42BPA0.63426969
81KSR20.63004160
82NEK90.61829426
83PDK30.59806707
84PDK40.59806707
85LRRK20.58608832
86SGK4940.58482107
87SGK2230.58482107
88BMPR1B0.57865379
89PRKG20.57136903
90NTRK20.56567791
91EIF2AK30.56307231
92ADRBK10.56057206
93STK380.55110310
94EIF2AK10.54831689
95MAPKAPK30.53272650
96FGFR30.52750461
97CAMK2G0.52301537
98NLK0.52293297
99NTRK10.50433955
100PRKD10.49621718
101SRC0.49529373
102ROCK20.49049501
103NEK10.48437668
104BRAF0.46258081
105PAK40.46120118
106SIK30.45484387
107ERBB20.44875371
108RPS6KA40.44536150
109PRKD20.43937798
110RPS6KA20.43424022
111ZAK0.43070758
112GSK3A0.41396544
113JAK10.41349121
114DAPK20.40979107
115INSR0.40526077
116MAP3K60.40517971
117ILK0.39891968
118FGFR40.38837308
119MAP3K80.37511873
120PRKCG0.36808519
121GRK10.36440364
122RAF10.36422806
123NME20.36174344
124MAP3K70.35895221
125BMPR20.35482889
126TBK10.34740820
127MAP3K140.34308226
128HIPK20.33278019
129PRKCI0.32269383
130STK30.31911167
131MAP3K10.31649758
132CASK0.30858427
133MAP2K20.30262672
134PKN20.29485929
135CAMK2B0.27885166
136PLK20.27317043
137STK390.26102368
138CAMK2D0.24433512
139ABL10.23720567
140TRIM280.23556487
141PAK10.22712909
142EIF2AK20.22079487
143MAPKAPK20.21673882

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.10659949
2Fatty acid biosynthesis_Homo sapiens_hsa000612.99978196
3Nitrogen metabolism_Homo sapiens_hsa009102.47147867
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.21576798
5Sulfur metabolism_Homo sapiens_hsa009202.01650668
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99424453
7Chemical carcinogenesis_Homo sapiens_hsa052041.88017512
8Circadian rhythm_Homo sapiens_hsa047101.83374090
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83210762
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80537399
11Malaria_Homo sapiens_hsa051441.80398347
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80227524
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.78768326
14Focal adhesion_Homo sapiens_hsa045101.72006549
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.66525616
16Fatty acid metabolism_Homo sapiens_hsa012121.59941158
17Fatty acid degradation_Homo sapiens_hsa000711.54447182
18Proteoglycans in cancer_Homo sapiens_hsa052051.53959281
19Sphingolipid metabolism_Homo sapiens_hsa006001.52514857
20Steroid biosynthesis_Homo sapiens_hsa001001.51187987
21Bladder cancer_Homo sapiens_hsa052191.51095949
22Pancreatic secretion_Homo sapiens_hsa049721.49766155
23Salmonella infection_Homo sapiens_hsa051321.46875572
24Adherens junction_Homo sapiens_hsa045201.46027677
25Mineral absorption_Homo sapiens_hsa049781.44551181
26Amoebiasis_Homo sapiens_hsa051461.44259789
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43819803
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38620378
29Shigellosis_Homo sapiens_hsa051311.38037681
30Small cell lung cancer_Homo sapiens_hsa052221.34435821
31Hippo signaling pathway_Homo sapiens_hsa043901.30901907
32Basal cell carcinoma_Homo sapiens_hsa052171.29059577
33Dilated cardiomyopathy_Homo sapiens_hsa054141.26504377
34Protein digestion and absorption_Homo sapiens_hsa049741.22931577
35Lysosome_Homo sapiens_hsa041421.21300941
36* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19966836
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19885983
38TGF-beta signaling pathway_Homo sapiens_hsa043501.19433490
39Galactose metabolism_Homo sapiens_hsa000521.18973797
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15998371
41p53 signaling pathway_Homo sapiens_hsa041151.15820872
42Glutathione metabolism_Homo sapiens_hsa004801.15091425
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10486781
44Vibrio cholerae infection_Homo sapiens_hsa051101.07044999
45PPAR signaling pathway_Homo sapiens_hsa033201.03850675
46Starch and sucrose metabolism_Homo sapiens_hsa005001.02770690
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01441512
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00273367
49Caffeine metabolism_Homo sapiens_hsa002321.00039211
50Other glycan degradation_Homo sapiens_hsa005110.94351283
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94080804
52Renal cell carcinoma_Homo sapiens_hsa052110.91903432
53Tight junction_Homo sapiens_hsa045300.90846890
54Pancreatic cancer_Homo sapiens_hsa052120.89768376
55Sulfur relay system_Homo sapiens_hsa041220.89465329
56ErbB signaling pathway_Homo sapiens_hsa040120.88980397
57Gastric acid secretion_Homo sapiens_hsa049710.88020807
58Chronic myeloid leukemia_Homo sapiens_hsa052200.85516478
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85510476
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85057198
61Pertussis_Homo sapiens_hsa051330.84858054
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84020248
63Endocytosis_Homo sapiens_hsa041440.83795494
64Toxoplasmosis_Homo sapiens_hsa051450.82292598
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79580641
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.79179320
67Fructose and mannose metabolism_Homo sapiens_hsa000510.78352239
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77721498
69Arginine and proline metabolism_Homo sapiens_hsa003300.77254590
70Hepatitis C_Homo sapiens_hsa051600.77222298
71Bile secretion_Homo sapiens_hsa049760.76077101
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76013629
73Retinol metabolism_Homo sapiens_hsa008300.74999350
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.74421837
75Thyroid cancer_Homo sapiens_hsa052160.74354223
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72399980
77Rap1 signaling pathway_Homo sapiens_hsa040150.68819787
78Thyroid hormone synthesis_Homo sapiens_hsa049180.67869811
79Melanogenesis_Homo sapiens_hsa049160.67015786
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66532706
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.66357893
82African trypanosomiasis_Homo sapiens_hsa051430.66225136
83Vitamin digestion and absorption_Homo sapiens_hsa049770.66076332
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66020088
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65938924
86Salivary secretion_Homo sapiens_hsa049700.65557098
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64544808
88Glioma_Homo sapiens_hsa052140.64422283
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63233719
90Rheumatoid arthritis_Homo sapiens_hsa053230.62627224
91Glycerolipid metabolism_Homo sapiens_hsa005610.62002481
92* Complement and coagulation cascades_Homo sapiens_hsa046100.60850858
93Hedgehog signaling pathway_Homo sapiens_hsa043400.60719790
94TNF signaling pathway_Homo sapiens_hsa046680.58303809
95Pathways in cancer_Homo sapiens_hsa052000.58204889
96Dorso-ventral axis formation_Homo sapiens_hsa043200.57978236
97Legionellosis_Homo sapiens_hsa051340.56712729
98Arachidonic acid metabolism_Homo sapiens_hsa005900.54320906
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51578764
100Prion diseases_Homo sapiens_hsa050200.50287927
101Wnt signaling pathway_Homo sapiens_hsa043100.49632955
102Histidine metabolism_Homo sapiens_hsa003400.47769150
103MicroRNAs in cancer_Homo sapiens_hsa052060.47254095
104Cocaine addiction_Homo sapiens_hsa050300.47146003
105Apoptosis_Homo sapiens_hsa042100.46769622
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45534843
107Melanoma_Homo sapiens_hsa052180.44324840
108Prostate cancer_Homo sapiens_hsa052150.44248858
109Axon guidance_Homo sapiens_hsa043600.42159747
110beta-Alanine metabolism_Homo sapiens_hsa004100.41921033
111Insulin secretion_Homo sapiens_hsa049110.41606880
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.39849676
113Gap junction_Homo sapiens_hsa045400.39224446
114Influenza A_Homo sapiens_hsa051640.38393343
115VEGF signaling pathway_Homo sapiens_hsa043700.35404171
116Estrogen signaling pathway_Homo sapiens_hsa049150.34699280
117Phagosome_Homo sapiens_hsa041450.34685291
118Peroxisome_Homo sapiens_hsa041460.33514721
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.33162826
120Phenylalanine metabolism_Homo sapiens_hsa003600.32970715
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32838878
122Insulin resistance_Homo sapiens_hsa049310.32651055
123Tyrosine metabolism_Homo sapiens_hsa003500.32490579
124N-Glycan biosynthesis_Homo sapiens_hsa005100.32172992
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31933970
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31784840
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31780656
128Endometrial cancer_Homo sapiens_hsa052130.31374709
129Pentose phosphate pathway_Homo sapiens_hsa000300.31227319

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