F13A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil mediated immunity (GO:0002446)6.36247966
2negative regulation of phagocytosis (GO:0050765)6.34380851
3respiratory burst (GO:0045730)6.18147066
4neutrophil activation involved in immune response (GO:0002283)6.10628587
5cellular extravasation (GO:0045123)5.34372444
6positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.30608419
7modulation of growth of symbiont involved in interaction with host (GO:0044144)5.23503765
8regulation of growth of symbiont in host (GO:0044126)5.23503765
9negative regulation of growth of symbiont in host (GO:0044130)5.23503765
10negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.23503765
11adenosine receptor signaling pathway (GO:0001973)5.20974215
12positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.19886204
13pinocytosis (GO:0006907)4.95482031
14positive regulation of mast cell activation involved in immune response (GO:0033008)4.94428217
15positive regulation of mast cell degranulation (GO:0043306)4.94428217
16angiogenesis involved in wound healing (GO:0060055)4.86046916
17mast cell activation (GO:0045576)4.79951486
18myeloid leukocyte mediated immunity (GO:0002444)4.77432004
19mast cell activation involved in immune response (GO:0002279)4.71867684
20mast cell degranulation (GO:0043303)4.71867684
21negative regulation of granulocyte differentiation (GO:0030853)4.63504114
22lipoxygenase pathway (GO:0019372)4.53394727
23positive regulation of monocyte chemotaxis (GO:0090026)4.38776113
24reactive oxygen species biosynthetic process (GO:1903409)4.36117832
25response to peptidoglycan (GO:0032494)4.34174252
26regulation of lymphocyte chemotaxis (GO:1901623)4.33212756
27T cell migration (GO:0072678)4.31414268
28regulation of platelet activation (GO:0010543)4.31309708
29response to fungus (GO:0009620)4.30687737
30positive regulation of B cell differentiation (GO:0045579)4.29818881
31regulation of integrin-mediated signaling pathway (GO:2001044)4.26782519
32myeloid cell activation involved in immune response (GO:0002275)4.24774650
33thrombin receptor signaling pathway (GO:0070493)4.23350977
34positive regulation of receptor recycling (GO:0001921)4.21265203
35regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.20618517
36low-density lipoprotein particle remodeling (GO:0034374)4.20617616
37regulation of B cell receptor signaling pathway (GO:0050855)4.16790640
38regulation of platelet aggregation (GO:0090330)4.15607686
39virion attachment to host cell (GO:0019062)4.14477777
40adhesion of symbiont to host cell (GO:0044650)4.14477777
41positive regulation of gamma-delta T cell activation (GO:0046645)4.11610558
42leukocyte degranulation (GO:0043299)4.09752026
43neutrophil activation (GO:0042119)4.07881600
44positive regulation of mast cell activation (GO:0033005)3.99392064
45disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.98345246
46killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.98345246
47production of molecular mediator involved in inflammatory response (GO:0002532)3.97807561
48positive regulation of T cell chemotaxis (GO:0010820)3.92798845
49regulation of T cell chemotaxis (GO:0010819)3.92798845
50immunoglobulin mediated immune response (GO:0016064)3.91417450
51adhesion of symbiont to host (GO:0044406)3.90212684
52regulation of mast cell activation (GO:0033003)3.85524723
53positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.84971365
54leukocyte migration involved in inflammatory response (GO:0002523)3.83918065
55lymphocyte chemotaxis (GO:0048247)3.78375369
56positive regulation of leukocyte degranulation (GO:0043302)3.78136512
57dendritic cell chemotaxis (GO:0002407)3.75933593
58granulocyte activation (GO:0036230)3.74658958
59defense response to fungus (GO:0050832)3.68257568
60G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.66082404
61negative regulation of mast cell activation (GO:0033004)3.65525168
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.65064699
63leukocyte mediated cytotoxicity (GO:0001909)3.64988772
64microglial cell activation (GO:0001774)3.63693559
65antigen processing and presentation of endogenous antigen (GO:0019883)3.62457650
66eosinophil chemotaxis (GO:0048245)3.62087572
67macrophage activation involved in immune response (GO:0002281)3.59490483
68leukotriene biosynthetic process (GO:0019370)3.59226273
69phagocytosis, engulfment (GO:0006911)3.57360691
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.56207532
71regulation of leukocyte degranulation (GO:0043300)3.54125751
72dendritic cell migration (GO:0036336)3.50815556
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49784020
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49784020
75regulation of interferon-beta biosynthetic process (GO:0045357)3.49082482
76negative regulation of B cell proliferation (GO:0030889)3.48245669
77regulation of monocyte chemotaxis (GO:0090025)3.47437059
78leukotriene metabolic process (GO:0006691)3.47153696
79cellular response to zinc ion (GO:0071294)3.46308971
80eosinophil migration (GO:0072677)3.45227375
81negative regulation of interleukin-17 production (GO:0032700)3.42662579
82regulation of interleukin-8 biosynthetic process (GO:0045414)3.42128532
83negative regulation of erythrocyte differentiation (GO:0045647)3.36616908
84B cell receptor signaling pathway (GO:0050853)3.36125262
85regulation of macrophage chemotaxis (GO:0010758)3.35711749
86platelet aggregation (GO:0070527)3.35500955
87Arp2/3 complex-mediated actin nucleation (GO:0034314)3.35210215
88positive regulation by symbiont of host defense response (GO:0052509)3.35001709
89modulation by symbiont of host defense response (GO:0052031)3.35001709
90modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35001709
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35001709
92positive regulation by organism of defense response of other organism involved in symbiotic interact3.35001709
93modulation by symbiont of host immune response (GO:0052553)3.35001709
94regulation of T-helper 2 cell differentiation (GO:0045628)3.32960816
95regulation of mast cell degranulation (GO:0043304)3.23677212
96G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.23450494
97negative regulation of homotypic cell-cell adhesion (GO:0034111)3.22950861
98regulation of lymphocyte migration (GO:2000401)3.22390058
99regulation of MHC class II biosynthetic process (GO:0045346)3.21092542
100positive regulation of cellular amide metabolic process (GO:0034250)3.19409596
101megakaryocyte development (GO:0035855)3.18821354
102regulation of B cell differentiation (GO:0045577)3.18645502
103heart contraction (GO:0060047)3.15941405
104heart process (GO:0003015)3.15941405
105mannose metabolic process (GO:0006013)3.14233126
106histamine secretion (GO:0001821)3.13533625
107macrophage activation (GO:0042116)3.09843726
108N-acetylneuraminate metabolic process (GO:0006054)3.09241104
109protein neddylation (GO:0045116)3.08605335
110positive regulation of lymphocyte migration (GO:2000403)3.08332351
111positive regulation of macrophage differentiation (GO:0045651)3.08263596
112negative regulation of platelet activation (GO:0010544)3.04168364
113regulation of phagocytosis (GO:0050764)3.02929806
114myeloid leukocyte activation (GO:0002274)3.01342777
115detection of other organism (GO:0098543)3.00407367
116regulation of early endosome to late endosome transport (GO:2000641)3.00178649
117regulation of regulated secretory pathway (GO:1903305)2.99913954
118detection of molecule of bacterial origin (GO:0032490)2.99606498
119purinergic receptor signaling pathway (GO:0035587)2.99229641
120regulation of apoptotic cell clearance (GO:2000425)2.98731285
121negative regulation of protein localization to plasma membrane (GO:1903077)2.98478777
122regulation of mast cell activation involved in immune response (GO:0033006)2.91377699
123positive regulation of T cell migration (GO:2000406)2.91013787
124B cell mediated immunity (GO:0019724)2.90371700
125regulation of inositol phosphate biosynthetic process (GO:0010919)2.90313934
126negative regulation of interleukin-12 production (GO:0032695)2.89924524
127regulation of mononuclear cell migration (GO:0071675)2.89524518
128negative regulation of cell killing (GO:0031342)2.87921094
129negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87921094
130positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.87295063
131hepatocyte apoptotic process (GO:0097284)2.86050728
132positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85680291
133detection of external biotic stimulus (GO:0098581)2.85447121
134cellular response to thyroid hormone stimulus (GO:0097067)2.84733200
135positive regulation of interleukin-1 beta secretion (GO:0050718)2.84487601
136positive regulation of tumor necrosis factor production (GO:0032760)2.84346340
137killing of cells of other organism (GO:0031640)2.84320791
138disruption of cells of other organism (GO:0044364)2.84320791
139amino sugar catabolic process (GO:0046348)2.83063689
140negative regulation of T-helper cell differentiation (GO:0045623)2.82578335
141negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82578335
142negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.82552117
143negative regulation of myeloid cell apoptotic process (GO:0033033)2.77982132
144response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77674387
145response to host immune response (GO:0052572)2.77674387
146negative regulation of type 2 immune response (GO:0002829)2.76988793
147positive regulation of type 2 immune response (GO:0002830)2.74761596
148regulation of gamma-delta T cell activation (GO:0046643)2.74760295
149positive regulation of regulated secretory pathway (GO:1903307)2.74650670
150positive regulation of chemokine secretion (GO:0090197)2.69315622
151actin filament polymerization (GO:0030041)2.68723923
152regulation of homotypic cell-cell adhesion (GO:0034110)2.67798913
153positive regulation of B cell mediated immunity (GO:0002714)2.66750149
154positive regulation of immunoglobulin mediated immune response (GO:0002891)2.66750149
155regulation of receptor recycling (GO:0001919)2.65133683
156negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.64072452
157positive regulation of blood coagulation (GO:0030194)2.63845275
158positive regulation of hemostasis (GO:1900048)2.63845275
159peptide catabolic process (GO:0043171)2.63746319
160membrane invagination (GO:0010324)2.61278322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.66741045
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.57184277
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.21121976
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.95222020
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.92579274
6MYB_21317192_ChIP-Seq_ERMYB_Mouse3.91307491
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.76029714
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.61213590
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.41154246
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.34171192
11SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.18744484
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89079706
13VDR_21846776_ChIP-Seq_THP-1_Human2.81450631
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.77992825
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75375135
16SCL_19346495_ChIP-Seq_HPC-7_Human2.72673400
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.70498805
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63514626
19SPI1_23547873_ChIP-Seq_NB4_Human2.62281167
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.61440711
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53177885
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49502227
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.37599368
24VDR_24763502_ChIP-Seq_THP-1_Human2.29741177
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22420069
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13708513
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11946706
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.06354583
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03384122
30GATA1_22025678_ChIP-Seq_K562_Human2.00698356
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00570419
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95119794
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90812931
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85679538
35SPI1_23127762_ChIP-Seq_K562_Human1.83673129
36MYB_26560356_Chip-Seq_TH2_Human1.80142699
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79082518
38* PU_27001747_Chip-Seq_BMDM_Mouse1.70380917
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67745079
40MAF_26560356_Chip-Seq_TH1_Human1.66727927
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65221609
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63621889
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58920496
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56929166
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55584414
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53667514
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53446136
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52043206
49MYC_22102868_ChIP-Seq_BL_Human1.51823420
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51132234
51MYB_26560356_Chip-Seq_TH1_Human1.47990903
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47793612
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40353546
54* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40049477
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38627078
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35659889
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34962221
58UTX_26944678_Chip-Seq_JUKART_Human1.32778223
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32082352
60GATA1_19941827_ChIP-Seq_MEL86_Mouse1.30709175
61RUNX_20019798_ChIP-Seq_JUKART_Human1.28918518
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27303852
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25455522
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24454489
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24017061
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.23370829
67GATA3_26560356_Chip-Seq_TH2_Human1.20302421
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18816662
69* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18303536
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17956657
71ELK4_26923725_Chip-Seq_MESODERM_Mouse1.17510816
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16733872
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14593259
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14221264
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10847453
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10771683
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10706997
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10614710
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.08415241
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07917949
81TCF7_22412390_ChIP-Seq_EML_Mouse1.05178284
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04579915
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04301620
84VDR_24787735_ChIP-Seq_THP-1_Human1.03935532
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03814453
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03075330
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03075330
88AR_21909140_ChIP-Seq_LNCAP_Human1.01647536
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01400561
90SPI1_20517297_ChIP-Seq_HL60_Human0.99658815
91KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99469923
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98690801
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96784042
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96149493
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93485660
96KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92011087
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.91020056
98GATA3_27048872_Chip-Seq_THYMUS_Human0.90117141
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87983690
100RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87208178
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.85448192
102EST1_17652178_ChIP-ChIP_JURKAT_Human0.85403253
103* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84948185
104CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81728536
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81214049
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79947741
107NCOR1_26117541_ChIP-Seq_K562_Human0.79709747
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.77661221
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77140472
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.76629046
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76140087
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76031318
113TFEB_21752829_ChIP-Seq_HELA_Human0.75062305
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72969130
115GATA2_19941826_ChIP-Seq_K562_Human0.71922618
116* HTT_18923047_ChIP-ChIP_STHdh_Human0.71818556
117SALL4_22934838_ChIP-ChIP_CD34+_Human0.71750274
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71676055
119GATA1_19941826_ChIP-Seq_K562_Human0.71123685
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70301795
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.69963122
122STAT1_20625510_ChIP-Seq_HELA_Human0.69871284
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69785584
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69698663
125GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68325368
126ESR1_20079471_ChIP-ChIP_T-47D_Human0.68283720
127* SMRT_27268052_Chip-Seq_Bcells_Human0.68007043
128CIITA_25753668_ChIP-Seq_RAJI_Human0.67551738
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66875157
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.66766592
131CLOCK_20551151_ChIP-Seq_293T_Human0.63645599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH4.29902301
2MP0001835_abnormal_antigen_presentation3.95180103
3MP0003436_decreased_susceptibility_to3.79556300
4MP0002419_abnormal_innate_immunity3.29964177
5MP0002148_abnormal_hypersensitivity_rea3.27259360
6MP0005058_abnormal_lysosome_morphology3.26283637
7MP0002396_abnormal_hematopoietic_system3.12326260
8MP0003724_increased_susceptibility_to3.06743609
9MP0009785_altered_susceptibility_to2.74558458
10MP0005000_abnormal_immune_tolerance2.68637131
11MP0005025_abnormal_response_to2.61134939
12MP0004510_myositis2.52639814
13MP0006054_spinal_hemorrhage2.52618460
14MP0002166_altered_tumor_susceptibility2.51526642
15MP0005464_abnormal_platelet_physiology2.32589997
16MP0003172_abnormal_lysosome_physiology2.31467199
17MP0009840_abnormal_foam_cell2.25035805
18MP0002452_abnormal_antigen_presenting2.24280599
19MP0001533_abnormal_skeleton_physiology2.24193486
20* MP0000343_altered_response_to2.22010997
21MP0001800_abnormal_humoral_immune2.19798782
22MP0003690_abnormal_glial_cell2.15529535
23MP0003191_abnormal_cellular_cholesterol2.15075362
24MP0005671_abnormal_response_to2.07672021
25MP0002420_abnormal_adaptive_immunity2.07244030
26MP0000604_amyloidosis2.06717992
27MP0003075_altered_response_to2.04336906
28MP0001819_abnormal_immune_cell2.03376429
29MP0002723_abnormal_immune_serum1.98237043
30MP0002006_tumorigenesis1.90123840
31MP0001790_abnormal_immune_system1.81766609
32MP0005387_immune_system_phenotype1.81766609
33MP0002405_respiratory_system_inflammati1.80284179
34MP0008057_abnormal_DNA_replication1.78859913
35MP0005174_abnormal_tail_pigmentation1.77526914
36MP0003303_peritoneal_inflammation1.77267017
37MP0005167_abnormal_blood-brain_barrier1.75692828
38MP0001845_abnormal_inflammatory_respons1.68605615
39MP0008438_abnormal_cutaneous_collagen1.65231426
40MP0003183_abnormal_peptide_metabolism1.64809979
41MP0009333_abnormal_splenocyte_physiolog1.64364292
42MP0000465_gastrointestinal_hemorrhage1.58580036
43MP0004084_abnormal_cardiac_muscle1.54850493
44MP0005164_abnormal_response_to1.54458288
45MP0000858_altered_metastatic_potential1.53408760
46MP0005397_hematopoietic_system_phenotyp1.53206327
47MP0001545_abnormal_hematopoietic_system1.53206327
48MP0000716_abnormal_immune_system1.51650654
49MP0010307_abnormal_tumor_latency1.51134130
50MP0010155_abnormal_intestine_physiology1.50367890
51MP0002398_abnormal_bone_marrow1.49134888
52MP0001853_heart_inflammation1.47791494
53MP0003448_altered_tumor_morphology1.47160676
54MP0000689_abnormal_spleen_morphology1.45535959
55MP0000685_abnormal_immune_system1.41915416
56MP0004808_abnormal_hematopoietic_stem1.40957219
57MP0008469_abnormal_protein_level1.35858080
58MP0002429_abnormal_blood_cell1.33763762
59MP0004130_abnormal_muscle_cell1.31474120
60MP0009764_decreased_sensitivity_to1.31094434
61MP0003300_gastrointestinal_ulcer1.30273089
62MP0002722_abnormal_immune_system1.28828638
63MP0008260_abnormal_autophagy1.25445516
64MP0002009_preneoplasia1.21685521
65MP0004883_abnormal_blood_vessel1.21594107
66MP0005083_abnormal_biliary_tract1.20818910
67MP0000490_abnormal_crypts_of1.15325001
68MP0003638_abnormal_response/metabolism_1.14972450
69MP0003828_pulmonary_edema1.13369051
70MP0005166_decreased_susceptibility_to1.12965345
71MP0000569_abnormal_digit_pigmentation1.12930515
72MP0003866_abnormal_defecation1.12793569
73MP0001915_intracranial_hemorrhage1.09240867
74MP0003656_abnormal_erythrocyte_physiolo1.08457468
75MP0010094_abnormal_chromosome_stability1.07664890
76MP0000249_abnormal_blood_vessel1.07265053
77MP0004147_increased_porphyrin_level1.05454157
78MP0003329_amyloid_beta_deposits1.04765433
79MP0002132_abnormal_respiratory_system1.03508754
80MP0003091_abnormal_cell_migration1.03221831
81MP0000230_abnormal_systemic_arterial0.99087766
82MP0002998_abnormal_bone_remodeling0.98560038
83MP0004782_abnormal_surfactant_physiolog0.97971777
84MP0005409_darkened_coat_color0.97565024
85MP0008873_increased_physiological_sensi0.96238416
86MP0000015_abnormal_ear_pigmentation0.95394998
87MP0005390_skeleton_phenotype0.94455689
88* MP0009763_increased_sensitivity_to0.94249497
89MP0005310_abnormal_salivary_gland0.92302083
90MP0004036_abnormal_muscle_relaxation0.91540951
91MP0003279_aneurysm0.91227450
92MP0006082_CNS_inflammation0.86781383
93MP0001663_abnormal_digestive_system0.86368401
94MP0003763_abnormal_thymus_physiology0.85824839
95MP0002019_abnormal_tumor_incidence0.85257270
96MP0003453_abnormal_keratinocyte_physiol0.84211220
97MP0008007_abnormal_cellular_replicative0.83467751
98MP0003111_abnormal_nucleus_morphology0.83146757
99MP0001851_eye_inflammation0.82296175
100MP0001958_emphysema0.82173877
101MP0003186_abnormal_redox_activity0.82020266
102MP0002933_joint_inflammation0.79746563
103MP0001542_abnormal_bone_strength0.78180663
104MP0003693_abnormal_embryo_hatching0.78092278
105MP0010352_gastrointestinal_tract_polyps0.78080325
106MP0005647_abnormal_sex_gland0.77387097
107MP0008874_decreased_physiological_sensi0.76511180
108MP0000703_abnormal_thymus_morphology0.76008576
109MP0005165_increased_susceptibility_to0.75576977
110MP0005023_abnormal_wound_healing0.74676849
111MP0009278_abnormal_bone_marrow0.73982195
112MP0002095_abnormal_skin_pigmentation0.73344840
113MP0003879_abnormal_hair_cell0.73304582
114MP0008775_abnormal_heart_ventricle0.72452772
115MP0009765_abnormal_xenobiotic_induced0.71640794
116MP0003566_abnormal_cell_adhesion0.70845071
117MP0003795_abnormal_bone_structure0.70712671
118MP0001727_abnormal_embryo_implantation0.70272211
119MP0003077_abnormal_cell_cycle0.69850880
120MP0004947_skin_inflammation0.69801931
121MP0005084_abnormal_gallbladder_morpholo0.69611690
122MP0000920_abnormal_myelination0.69100273
123MP0002254_reproductive_system_inflammat0.68786646
124MP0002877_abnormal_melanocyte_morpholog0.68547297
125MP0005584_abnormal_enzyme/coenzyme_acti0.68346684
126MP0005666_abnormal_adipose_tissue0.67159831
127MP0002971_abnormal_brown_adipose0.67133118
128MP0005365_abnormal_bile_salt0.66844800
129MP0010368_abnormal_lymphatic_system0.63645548
130MP0004484_altered_response_of0.62870943

Predicted human phenotypes

RankGene SetZ-score
1Purpura (HP:0000979)6.56979437
2Recurrent abscess formation (HP:0002722)6.51720135
3Recurrent bacterial skin infections (HP:0005406)6.24826558
4Systemic lupus erythematosus (HP:0002725)6.22125620
5Increased mean platelet volume (HP:0011877)6.19463243
6Menorrhagia (HP:0000132)5.73788181
7Eczematoid dermatitis (HP:0000976)5.29974999
8* Epistaxis (HP:0000421)5.23621743
9Gingival bleeding (HP:0000225)5.22907334
10Glomerulonephritis (HP:0000099)4.63511346
11Myositis (HP:0100614)4.56814683
12Thrombocytosis (HP:0001894)4.38796517
13Recurrent gram-negative bacterial infections (HP:0005420)4.30759744
14Papilledema (HP:0001085)4.24309701
15Elevated erythrocyte sedimentation rate (HP:0003565)4.11389087
16Abnormality of complement system (HP:0005339)4.01871510
17Vacuolated lymphocytes (HP:0001922)3.97651743
18Orchitis (HP:0100796)3.92636194
19Abnormal platelet function (HP:0011869)3.91490235
20Impaired platelet aggregation (HP:0003540)3.91490235
21Complement deficiency (HP:0004431)3.77381861
22* Spontaneous hematomas (HP:0007420)3.62510324
23Abnormality of the prostate (HP:0008775)3.58776736
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.52855560
25Chronic obstructive pulmonary disease (HP:0006510)3.52704753
26Obstructive lung disease (HP:0006536)3.52704753
27Increased cerebral lipofuscin (HP:0011813)3.49123264
28Agnosia (HP:0010524)3.45854275
29Recurrent skin infections (HP:0001581)3.40960254
30Periodontitis (HP:0000704)3.38001037
31Abnormality of the vasculature of the conjunctiva (HP:0008054)3.36137547
32Mutism (HP:0002300)3.32667421
33Keratoconjunctivitis sicca (HP:0001097)3.30978783
34Optic neuritis (HP:0100653)3.29909837
35Retrobulbar optic neuritis (HP:0100654)3.29909837
36IgM deficiency (HP:0002850)3.17884606
37Abnormality of macrophages (HP:0004311)3.17276992
38Cellulitis (HP:0100658)3.16082891
39Gingivitis (HP:0000230)3.14261994
40Meningitis (HP:0001287)3.14109235
41Conjunctival telangiectasia (HP:0000524)3.03113032
42Recurrent viral infections (HP:0004429)3.02815253
43Stomatitis (HP:0010280)3.00188217
44Keratoconjunctivitis (HP:0001096)2.96714642
45Petechiae (HP:0000967)2.96129965
46Mediastinal lymphadenopathy (HP:0100721)2.92980547
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.92054550
48Eosinophilia (HP:0001880)2.91103607
49Dysostosis multiplex (HP:0000943)2.88018200
50Hyperlipoproteinemia (HP:0010980)2.86303980
51Abnormality of T cell physiology (HP:0011840)2.81604503
52Pulmonary infiltrates (HP:0002113)2.76979098
53Hepatosplenomegaly (HP:0001433)2.75487660
54Nephritis (HP:0000123)2.67847677
55Recurrent fungal infections (HP:0002841)2.67468575
56J-shaped sella turcica (HP:0002680)2.66965570
57Disinhibition (HP:0000734)2.64903740
58Granulocytopenia (HP:0001913)2.62050613
59Chronic otitis media (HP:0000389)2.60297362
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58712707
61Osteomyelitis (HP:0002754)2.58249422
62Chest pain (HP:0100749)2.50322524
63Thick nail (HP:0001805)2.47035198
64Mucopolysacchariduria (HP:0008155)2.46407476
65Urinary glycosaminoglycan excretion (HP:0003541)2.46407476
66Cutaneous melanoma (HP:0012056)2.44795096
67Axonal loss (HP:0003447)2.44643509
68Recurrent pneumonia (HP:0006532)2.43719943
69* Bruising susceptibility (HP:0000978)2.43136180
70Leukocytosis (HP:0001974)2.42895773
71Peritonitis (HP:0002586)2.38432309
72Amyloidosis (HP:0011034)2.35919038
73Abnormality of the pleura (HP:0002103)2.34259278
74Abnormality of liposaccharide metabolism (HP:0010968)2.30342096
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.30342096
76Abnormality of glycolipid metabolism (HP:0010969)2.30342096
77Loss of speech (HP:0002371)2.25904316
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.24775160
79Osteolytic defects of the hand bones (HP:0009699)2.24775160
80Pustule (HP:0200039)2.21462615
81Vertigo (HP:0002321)2.19096539
82Vasculitis (HP:0002633)2.17441429
83Arterial thrombosis (HP:0004420)2.17301812
84Abnormality of iron homeostasis (HP:0011031)2.17156604
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14093499
86Abnormality of polysaccharide metabolism (HP:0011012)2.14093499
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14093499
88Thoracic kyphosis (HP:0002942)2.13639573
89Inflammation of the large intestine (HP:0002037)2.12101496
90Spinal muscular atrophy (HP:0007269)2.11821143
91Dyschromatopsia (HP:0007641)2.09668089
92Hematochezia (HP:0002573)2.08861685
93Abnormality of B cell number (HP:0010975)2.08624075
94B lymphocytopenia (HP:0010976)2.08624075
95Poikilocytosis (HP:0004447)2.08348575
96Premature loss of primary teeth (HP:0006323)2.06564199
97Encephalitis (HP:0002383)2.06502757
98Keratitis (HP:0000491)2.06255274
99Urticaria (HP:0001025)2.06073622
100Nuclear cataract (HP:0100018)2.05442732
101Hemoptysis (HP:0002105)2.04962413
102Myocardial infarction (HP:0001658)2.04774235
103Increased serum ferritin (HP:0003281)2.03886928
104Abnormality of eosinophils (HP:0001879)2.03406715
105Panhypogammaglobulinemia (HP:0003139)2.02808224
106Increased density of long bones (HP:0006392)2.02623199
107Sepsis (HP:0100806)2.00441455
108Basal ganglia calcification (HP:0002135)1.99839201
109Mucosal telangiectasiae (HP:0100579)1.99145116
110Gangrene (HP:0100758)1.98376212
111Skin ulcer (HP:0200042)1.97884082
112Nonimmune hydrops fetalis (HP:0001790)1.97404258
113Joint swelling (HP:0001386)1.96692698
114Ventricular fibrillation (HP:0001663)1.96495495
115Abnormality of the lumbar spine (HP:0100712)1.95906292
116Chromsome breakage (HP:0040012)1.95897600
117Abnormal pupillary function (HP:0007686)1.93811393
118Gastrointestinal inflammation (HP:0004386)1.92531714
119Abnormality of T cells (HP:0002843)1.92384788
120Recurrent lower respiratory tract infections (HP:0002783)1.91666144
121Acanthocytosis (HP:0001927)1.91240789
122Prolonged bleeding time (HP:0003010)1.89451952
123Prostate neoplasm (HP:0100787)1.89232101
124Deformed sella turcica (HP:0002681)1.88820888
125Asymmetric septal hypertrophy (HP:0001670)1.88699154
126Abnormality of the thoracic spine (HP:0100711)1.88265949
127Recurrent bronchitis (HP:0002837)1.88214431
128Interstitial pulmonary disease (HP:0006530)1.85505418
129Paralysis (HP:0003470)1.85468202
130Episodic fever (HP:0001954)1.84952997
131Upper motor neuron abnormality (HP:0002127)1.83722099
132Hypergammaglobulinemia (HP:0010702)1.82086031
133Abnormality of pyrimidine metabolism (HP:0004353)1.81118290
134Gastrointestinal infarctions (HP:0005244)1.79733050
135Pulmonary embolism (HP:0002204)1.79707898
136Abnormal platelet volume (HP:0011876)1.79463828
137Tetraparesis (HP:0002273)1.78676679
138Abnormality of transition element cation homeostasis (HP:0011030)1.77280140
139Amaurosis fugax (HP:0100576)1.75573406
140Abnormality of lateral ventricle (HP:0030047)1.74519220
141Polycythemia (HP:0001901)1.74189756
142Neuronal loss in central nervous system (HP:0002529)1.70703590
143T lymphocytopenia (HP:0005403)1.68219435
144Thrombophlebitis (HP:0004418)1.67258093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.37641275
2IRAK43.83245866
3TEC3.74979761
4TYK23.10281128
5MAP3K143.07011630
6BTK2.81953969
7KIT2.76068531
8TAOK32.51337567
9CLK12.41346251
10ERN12.25731371
11BMX2.13104227
12EIF2AK12.11543815
13ITK2.08087225
14TGFBR22.01760399
15EPHB12.00349836
16STK101.93236155
17EEF2K1.88933797
18MAP2K31.85034734
19RIPK41.76814025
20CSF1R1.73934154
21FGR1.70722749
22IRAK31.67828277
23SCYL21.62831374
24MST41.61906433
25MAP4K11.60117857
26BMPR21.58637755
27PIK3CG1.58352897
28GRK71.52884801
29SYK1.52726798
30FES1.43760010
31TRPM71.39839700
32PTK2B1.36783789
33TNK21.35084182
34LYN1.34133963
35HCK1.32462355
36JAK11.30037554
37ZAP701.26960221
38MATK1.18335441
39NEK91.17432565
40JAK21.12733249
41IKBKE1.10185197
42CSK1.07896964
43TTN1.06916870
44PDK11.02215002
45PAK41.00497353
46IKBKB1.00167179
47MAP3K60.99925591
48CAMK1G0.98883111
49TSSK60.97237974
50PDPK10.96741926
51TESK20.96633240
52STK160.94849952
53PIM20.94559543
54TBK10.93835907
55RPS6KL10.92818795
56RPS6KC10.92818795
57LCK0.92732789
58FLT30.91581432
59LRRK20.88525282
60NEK10.88216843
61MAP3K50.88121371
62GRK50.87530201
63MAP3K10.87071165
64RPS6KA60.85997210
65CDK60.85825999
66EIF2AK20.85386453
67RPS6KA20.85331008
68MAPKAPK30.84756086
69ZAK0.83071413
70ABL20.82529853
71IRAK10.82227111
72TXK0.80818322
73STK40.80376405
74MAPK120.80168171
75STK30.80085474
76EPHA30.78528772
77ARAF0.77698830
78TGFBR10.77248488
79MAP3K130.76436235
80ADRBK20.74652670
81PIM10.73122791
82TAOK20.72773230
83ATR0.72421389
84MARK30.72046789
85SIK30.70999777
86DAPK10.70626362
87STK240.67957835
88PRKD10.66711786
89PRKCD0.65545227
90MAP3K110.65317063
91PASK0.64542248
92ADRBK10.64343543
93RET0.63905178
94JAK30.63430527
95TAOK10.62738039
96CAMK1D0.61770592
97ILK0.60108559
98VRK10.59974297
99PDGFRB0.59954850
100YES10.59452624
101SGK30.58930562
102BUB10.58658947
103FER0.58648585
104CDC42BPA0.58203332
105PAK10.57269156
106ACVR1B0.54983741
107MAP3K30.52317253
108GRK60.52304721
109EIF2AK30.52055925
110DAPK20.51103245
111MAPK40.50971510
112MAP3K80.50567414
113ABL10.50131890
114SGK20.50004878
115TESK10.48511403
116IRAK20.48035386
117CAMKK20.47801029
118TTK0.47712291
119CHUK0.47305854
120BRSK20.46322268
121MAPKAPK20.45966426
122NEK20.45820451
123MAPK70.45273012
124FGFR30.45003736
125KSR20.44901716
126PRKCQ0.44063497
127DDR20.43342920
128MAPKAPK50.43195348
129MARK20.42512540
130RPS6KB10.41965261
131MAP3K120.41853599
132TRIB30.38589125
133IGF1R0.38427361
134MYLK0.38360496
135PRPF4B0.38194584
136DAPK30.37980464
137PRKACG0.36787909
138FRK0.36447717
139PRKG10.35504765
140FYN0.34697069
141TLK10.33828347
142PLK30.32595957
143CDK40.27592649
144CDC70.26614111
145RPS6KA40.25748881
146HIPK20.24980234
147MOS0.24660854

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.65801307
2Leishmaniasis_Homo sapiens_hsa051403.22530761
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.18727632
4Other glycan degradation_Homo sapiens_hsa005113.16221104
5DNA replication_Homo sapiens_hsa030303.06738858
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.68068238
7Pertussis_Homo sapiens_hsa051332.58123259
8Lysosome_Homo sapiens_hsa041422.47324122
9Osteoclast differentiation_Homo sapiens_hsa043802.40782770
10Legionellosis_Homo sapiens_hsa051342.15263102
11Non-homologous end-joining_Homo sapiens_hsa034501.93555742
12Phagosome_Homo sapiens_hsa041451.92466628
13Tuberculosis_Homo sapiens_hsa051521.89291452
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85870948
15Mismatch repair_Homo sapiens_hsa034301.81498500
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.81231038
17Graft-versus-host disease_Homo sapiens_hsa053321.81222293
18Base excision repair_Homo sapiens_hsa034101.74463705
19Autoimmune thyroid disease_Homo sapiens_hsa053201.74382436
20Measles_Homo sapiens_hsa051621.66904246
21Antigen processing and presentation_Homo sapiens_hsa046121.66043448
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.65545557
23B cell receptor signaling pathway_Homo sapiens_hsa046621.61141487
24Toxoplasmosis_Homo sapiens_hsa051451.57308288
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55312708
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54480754
27Malaria_Homo sapiens_hsa051441.44599484
28Pentose phosphate pathway_Homo sapiens_hsa000301.42741402
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36413207
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.35085677
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34962159
32Chemokine signaling pathway_Homo sapiens_hsa040621.32134164
33Salmonella infection_Homo sapiens_hsa051321.29930499
34Type I diabetes mellitus_Homo sapiens_hsa049401.19996637
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19884763
36Primary immunodeficiency_Homo sapiens_hsa053401.19220971
37Influenza A_Homo sapiens_hsa051641.18934878
38Apoptosis_Homo sapiens_hsa042101.18643087
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17716329
40* Complement and coagulation cascades_Homo sapiens_hsa046101.12179823
41Herpes simplex infection_Homo sapiens_hsa051681.10624749
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09898479
43Homologous recombination_Homo sapiens_hsa034401.07345367
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07020036
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04401538
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04208614
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.04073267
48N-Glycan biosynthesis_Homo sapiens_hsa005100.99678734
49Asthma_Homo sapiens_hsa053100.97708465
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96981900
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96801594
52Collecting duct acid secretion_Homo sapiens_hsa049660.96499218
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95726147
54Viral myocarditis_Homo sapiens_hsa054160.95335955
55ABC transporters_Homo sapiens_hsa020100.95119340
56Renin-angiotensin system_Homo sapiens_hsa046140.94962761
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94506041
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.93485747
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.92359973
60Arachidonic acid metabolism_Homo sapiens_hsa005900.91574882
61Caffeine metabolism_Homo sapiens_hsa002320.90411264
62Gap junction_Homo sapiens_hsa045400.89219447
63Hepatitis B_Homo sapiens_hsa051610.88236874
64Hematopoietic cell lineage_Homo sapiens_hsa046400.84884748
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84041342
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83893543
67Shigellosis_Homo sapiens_hsa051310.83485993
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81536416
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80009095
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78476196
71Platelet activation_Homo sapiens_hsa046110.78408998
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.76631748
73Renal cell carcinoma_Homo sapiens_hsa052110.76093796
74ECM-receptor interaction_Homo sapiens_hsa045120.75718668
75Galactose metabolism_Homo sapiens_hsa000520.73815401
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73159013
77One carbon pool by folate_Homo sapiens_hsa006700.72413466
78Nucleotide excision repair_Homo sapiens_hsa034200.69894526
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68834444
80Systemic lupus erythematosus_Homo sapiens_hsa053220.66745183
81Chronic myeloid leukemia_Homo sapiens_hsa052200.65838352
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65507950
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64386158
84Pancreatic cancer_Homo sapiens_hsa052120.63763551
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63663032
86Focal adhesion_Homo sapiens_hsa045100.62274682
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61658034
88Starch and sucrose metabolism_Homo sapiens_hsa005000.60841219
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.60186529
90Serotonergic synapse_Homo sapiens_hsa047260.59626877
91Acute myeloid leukemia_Homo sapiens_hsa052210.59390376
92Rap1 signaling pathway_Homo sapiens_hsa040150.59229204
93VEGF signaling pathway_Homo sapiens_hsa043700.58722879
94Long-term depression_Homo sapiens_hsa047300.53705688
95HIF-1 signaling pathway_Homo sapiens_hsa040660.53147307
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51791480
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51645406
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51636012
99Renin secretion_Homo sapiens_hsa049240.51344998
100Hepatitis C_Homo sapiens_hsa051600.50470578
101Pancreatic secretion_Homo sapiens_hsa049720.49835525
102Choline metabolism in cancer_Homo sapiens_hsa052310.49755392
103Protein export_Homo sapiens_hsa030600.49578691
104Cell cycle_Homo sapiens_hsa041100.48751177
105Ras signaling pathway_Homo sapiens_hsa040140.48668407
106Glioma_Homo sapiens_hsa052140.47410604
107p53 signaling pathway_Homo sapiens_hsa041150.46304193
108Endometrial cancer_Homo sapiens_hsa052130.45900706
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45888596
110Rheumatoid arthritis_Homo sapiens_hsa053230.45508909
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.45376512
112Dilated cardiomyopathy_Homo sapiens_hsa054140.44741398
113Prolactin signaling pathway_Homo sapiens_hsa049170.43805047
114GnRH signaling pathway_Homo sapiens_hsa049120.42833475
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42163768
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39408299
117Endocytosis_Homo sapiens_hsa041440.36752353
118Viral carcinogenesis_Homo sapiens_hsa052030.36388799
119Sphingolipid metabolism_Homo sapiens_hsa006000.35895962
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35815514
121TNF signaling pathway_Homo sapiens_hsa046680.35752757
122Small cell lung cancer_Homo sapiens_hsa052220.35072218
123Non-small cell lung cancer_Homo sapiens_hsa052230.34516192
124Amoebiasis_Homo sapiens_hsa051460.34189894
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33954692
126Epstein-Barr virus infection_Homo sapiens_hsa051690.33509114
127Prion diseases_Homo sapiens_hsa050200.32777051
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.29432156
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.29160667
130Allograft rejection_Homo sapiens_hsa053300.28294836
131Fanconi anemia pathway_Homo sapiens_hsa034600.25488186
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24482669
133T cell receptor signaling pathway_Homo sapiens_hsa046600.22298405

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