F11R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)4.74468629
2hemidesmosome assembly (GO:0031581)4.17989011
3multicellular organismal water homeostasis (GO:0050891)4.01305511
4establishment of skin barrier (GO:0061436)3.96847191
5positive regulation of Cdc42 GTPase activity (GO:0043089)3.92534863
6sulfur amino acid catabolic process (GO:0000098)3.79312752
7establishment of apical/basal cell polarity (GO:0035089)3.79128264
8desmosome organization (GO:0002934)3.78454562
9calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.75655683
10regulation of posttranscriptional gene silencing (GO:0060147)3.67737706
11regulation of gene silencing by miRNA (GO:0060964)3.67737706
12regulation of gene silencing by RNA (GO:0060966)3.67737706
13primary alcohol catabolic process (GO:0034310)3.62857902
14cysteine metabolic process (GO:0006534)3.58199679
15epithelial cell differentiation involved in prostate gland development (GO:0060742)3.57664532
16surfactant homeostasis (GO:0043129)3.54183179
17interferon-gamma secretion (GO:0072643)3.52476249
18L-alpha-amino acid transmembrane transport (GO:1902475)3.47117668
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.43335306
20L-phenylalanine metabolic process (GO:0006558)3.43335306
21bile acid and bile salt transport (GO:0015721)3.42925311
22water homeostasis (GO:0030104)3.36918669
23L-phenylalanine catabolic process (GO:0006559)3.27710479
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.27710479
25negative regulation of keratinocyte proliferation (GO:0010839)3.25371581
26transcytosis (GO:0045056)3.20658550
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.19875489
28COPI coating of Golgi vesicle (GO:0048205)3.19632970
29Golgi transport vesicle coating (GO:0048200)3.19632970
30intestinal epithelial cell development (GO:0060576)3.19406819
31regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.14868741
32negative regulation of fibrinolysis (GO:0051918)3.12294626
33amino-acid betaine metabolic process (GO:0006577)3.11887150
34reverse cholesterol transport (GO:0043691)3.10393022
35vitamin transmembrane transport (GO:0035461)3.08967227
36positive regulation of triglyceride lipase activity (GO:0061365)3.08404356
37positive regulation of lipoprotein lipase activity (GO:0051006)3.08404356
38ethanol metabolic process (GO:0006067)3.06875340
39aromatic amino acid family catabolic process (GO:0009074)3.05222351
40protein carboxylation (GO:0018214)3.04694656
41peptidyl-glutamic acid carboxylation (GO:0017187)3.04694656
42regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.03786686
43high-density lipoprotein particle remodeling (GO:0034375)3.02325297
44homocysteine metabolic process (GO:0050667)3.01765991
45serine family amino acid catabolic process (GO:0009071)3.01267825
46urea cycle (GO:0000050)3.00997527
47urea metabolic process (GO:0019627)3.00997527
48glyoxylate metabolic process (GO:0046487)2.99099035
49proline biosynthetic process (GO:0006561)2.99068369
50endothelium development (GO:0003158)2.97797984
51pyrimidine-containing compound transmembrane transport (GO:0072531)2.96961126
52NADPH regeneration (GO:0006740)2.95663783
53drug catabolic process (GO:0042737)2.94717679
54peptide catabolic process (GO:0043171)2.93809141
55response to nitrosative stress (GO:0051409)2.92373855
56regulation of protein activation cascade (GO:2000257)2.92194518
57* tight junction assembly (GO:0070830)2.90980685
58flavonoid metabolic process (GO:0009812)2.90660589
59positive regulation of SMAD protein import into nucleus (GO:0060391)2.89282386
60tryptophan catabolic process (GO:0006569)2.89253555
61indole-containing compound catabolic process (GO:0042436)2.89253555
62indolalkylamine catabolic process (GO:0046218)2.89253555
63negative regulation of cell fate specification (GO:0009996)2.88971220
64basement membrane organization (GO:0071711)2.88305215
65plasma lipoprotein particle assembly (GO:0034377)2.88082108
66regulation of triglyceride catabolic process (GO:0010896)2.87775620
67tryptophan metabolic process (GO:0006568)2.87297448
68xenobiotic catabolic process (GO:0042178)2.84948721
69regulation of cholesterol homeostasis (GO:2000188)2.84329725
70vitamin transport (GO:0051180)2.82327891
71very-low-density lipoprotein particle assembly (GO:0034379)2.82106775
72urate metabolic process (GO:0046415)2.80556188
73regulation of complement activation (GO:0030449)2.80459548
74regulation of cardioblast differentiation (GO:0051890)2.80394667
75kynurenine metabolic process (GO:0070189)2.79742137
76phospholipid efflux (GO:0033700)2.79462925
77nitrogen cycle metabolic process (GO:0071941)2.78051007
78polarized epithelial cell differentiation (GO:0030859)2.77975131
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77657846
80pentose-phosphate shunt (GO:0006098)2.77494892
81cholesterol homeostasis (GO:0042632)2.77169103
82epithelial cell-cell adhesion (GO:0090136)2.76530521
83sterol homeostasis (GO:0055092)2.76406856
84complement activation, alternative pathway (GO:0006957)2.75437107
85pre-miRNA processing (GO:0031054)2.74679701
86triglyceride homeostasis (GO:0070328)2.74429012
87acylglycerol homeostasis (GO:0055090)2.74429012
88proline metabolic process (GO:0006560)2.74321940
89amyloid precursor protein catabolic process (GO:0042987)2.73959597
90histone H3-K36 demethylation (GO:0070544)2.73158011
91renal absorption (GO:0070293)2.72374231
92intestinal cholesterol absorption (GO:0030299)2.71744795
93alpha-linolenic acid metabolic process (GO:0036109)2.71696392
94nucleotide-sugar biosynthetic process (GO:0009226)2.69656168
95regulation of fibrinolysis (GO:0051917)2.69519891
96phospholipid homeostasis (GO:0055091)2.69344334
97trophectodermal cell differentiation (GO:0001829)2.69086888
98protein autoprocessing (GO:0016540)2.68773605
99protein complex localization (GO:0031503)2.67333616
100fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.66913863
101lysine metabolic process (GO:0006553)2.65335360
102lysine catabolic process (GO:0006554)2.65335360
103gap junction assembly (GO:0016264)2.64644179
104polyketide metabolic process (GO:0030638)2.64635744
105doxorubicin metabolic process (GO:0044598)2.64635744
106daunorubicin metabolic process (GO:0044597)2.64635744
107dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.62967727
108regulation of bile acid biosynthetic process (GO:0070857)2.62611057
109establishment or maintenance of monopolar cell polarity (GO:0061339)2.60769511
110establishment of monopolar cell polarity (GO:0061162)2.60769511
111glucuronate metabolic process (GO:0019585)2.60761080
112uronic acid metabolic process (GO:0006063)2.60761080
113embryonic process involved in female pregnancy (GO:0060136)2.60638155
114regulation of cell fate specification (GO:0042659)2.58859857
115glycine metabolic process (GO:0006544)2.58693950
116regulation of water loss via skin (GO:0033561)2.57975084
117chemical homeostasis within a tissue (GO:0048875)2.57957803
118keratinocyte proliferation (GO:0043616)2.57570496
119negative regulation of sterol transport (GO:0032372)2.57421546
120negative regulation of cholesterol transport (GO:0032375)2.57421546
121pantothenate metabolic process (GO:0015939)2.57122194
122L-ascorbic acid metabolic process (GO:0019852)2.56316791
123lipoprotein metabolic process (GO:0042157)2.54590264
124regulation of transforming growth factor beta production (GO:0071634)2.54384312
125fibrinolysis (GO:0042730)2.54279132
126biotin metabolic process (GO:0006768)2.53698555
127bile acid biosynthetic process (GO:0006699)2.53069304
128bile acid metabolic process (GO:0008206)2.52400065
129* cell-cell junction assembly (GO:0007043)2.51994019
130regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.51960331
131branching involved in labyrinthine layer morphogenesis (GO:0060670)2.51496693
132axonemal dynein complex assembly (GO:0070286)2.50989472
133cellular glucuronidation (GO:0052695)2.50491653
134exogenous drug catabolic process (GO:0042738)2.50176422
135regulation of cholesterol esterification (GO:0010872)2.49415220
136regulation of lipoprotein particle clearance (GO:0010984)2.48922828
137regulation of keratinocyte differentiation (GO:0045616)2.48668574
138glomerular epithelial cell development (GO:0072310)2.47647866
139carnitine metabolic process (GO:0009437)2.47332712
140O-glycan processing (GO:0016266)2.47276747
141regulation of keratinocyte proliferation (GO:0010837)2.45251059
142intestinal absorption (GO:0050892)2.45229926
143cell-substrate junction assembly (GO:0007044)2.44459085
144drug metabolic process (GO:0017144)2.44179516
145positive regulation of epidermal cell differentiation (GO:0045606)2.44061131
146hormone catabolic process (GO:0042447)2.43666864
147negative regulation of lipase activity (GO:0060192)2.42938141
148plasma lipoprotein particle clearance (GO:0034381)2.42394276
149sodium-independent organic anion transport (GO:0043252)2.41256317
150regulation of transforming growth factor beta1 production (GO:0032908)2.41028232
151establishment or maintenance of bipolar cell polarity (GO:0061245)2.40733728
152establishment or maintenance of apical/basal cell polarity (GO:0035088)2.40733728
153diterpenoid biosynthetic process (GO:0016102)2.40123535
154aromatic amino acid family metabolic process (GO:0009072)2.39702170
155serine family amino acid metabolic process (GO:0009069)2.39015904
156ethanol oxidation (GO:0006069)2.38889969
157glucose catabolic process (GO:0006007)2.38544996
158fatty acid beta-oxidation (GO:0006635)2.38434885
159protein-lipid complex assembly (GO:0065005)2.38086021
160acute-phase response (GO:0006953)2.37534637
161arginine metabolic process (GO:0006525)2.36942789
162cytoskeletal anchoring at plasma membrane (GO:0007016)2.36685726
163fatty acid oxidation (GO:0019395)2.36559848
164epoxygenase P450 pathway (GO:0019373)2.36347843
165sphingomyelin metabolic process (GO:0006684)2.36262270
166keratinocyte development (GO:0003334)2.36170145
167amyloid precursor protein metabolic process (GO:0042982)2.35287947
168iron ion import (GO:0097286)2.34524375
169regulation of transforming growth factor beta2 production (GO:0032909)2.33102976
170regulation of apoptotic cell clearance (GO:2000425)2.30980631
171negative regulation of cell fate commitment (GO:0010454)2.27141012
172paraxial mesoderm development (GO:0048339)2.26010197
173toxin transport (GO:1901998)2.25023910
174nodal signaling pathway (GO:0038092)2.24418620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.67594140
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.47212135
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.11936083
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.91423540
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.85225963
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.83162574
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.36741391
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.87462836
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81799684
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.75087312
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.56073390
12STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.42268702
13* CLOCK_20551151_ChIP-Seq_293T_Human2.40948633
14* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40353435
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.40067352
16GATA1_22025678_ChIP-Seq_K562_Human2.36688401
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.11752781
18ZNF263_19887448_ChIP-Seq_K562_Human2.10826372
19* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.06071066
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01746825
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92924461
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.92452819
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92285344
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.90625451
25* GATA4_25053715_ChIP-Seq_YYC3_Human1.89866170
26* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87474818
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80718077
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.77868249
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75625369
30SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74897290
31* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71402437
32* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67688292
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.67227166
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66170209
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66170209
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66170209
37* SOX2_20726797_ChIP-Seq_SW620_Human1.62965138
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60620886
39* GATA6_25053715_ChIP-Seq_YYC3_Human1.53209966
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52881410
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52599872
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52389887
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49948164
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.46142012
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43270551
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42173833
47* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40697916
48* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40697916
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39631501
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39163892
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38571969
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38387247
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36937723
54* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36663061
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.35498721
56RACK7_27058665_Chip-Seq_MCF-7_Human1.34522948
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.33037785
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.32478920
59* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31357230
60E2F7_22180533_ChIP-Seq_HELA_Human1.30839649
61ATF3_27146783_Chip-Seq_COLON_Human1.30066804
62* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24929263
63* CHD1_26751641_Chip-Seq_LNCaP_Human1.22371392
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20759946
65* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19178772
66* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18616944
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16367260
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.14855818
69* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14801286
70AR_21909140_ChIP-Seq_LNCAP_Human1.12877880
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12402105
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12032871
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11632092
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11572402
75TCF7_22412390_ChIP-Seq_EML_Mouse1.11395953
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11312975
77GATA3_24758297_ChIP-Seq_MCF-7_Human1.11152479
78KLF5_25053715_ChIP-Seq_YYC3_Human1.10278571
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08623998
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08491900
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08175487
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07268023
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06616910
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04860468
85* KAP1_27257070_Chip-Seq_ESCs_Mouse1.04029326
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.03343116
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03319986
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02424878
89* NCOR1_26117541_ChIP-Seq_K562_Human1.01977069
90LXR_22292898_ChIP-Seq_THP-1_Human1.01285344
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.00961253
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00452438
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99640148
94SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99471514
95SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96486363
96* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92997874
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92432050
98* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92051916
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91973006
100BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91780525
101* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90417081
102ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90296608
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89657201
104MYC_22102868_ChIP-Seq_BL_Human0.89374857
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89122463
106TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88285964
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88201227
108FOXA2_19822575_ChIP-Seq_HepG2_Human0.87801803
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87767165
110MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87041747
111* HNF4A_19822575_ChIP-Seq_HepG2_Human0.85641934
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85634433
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83446179
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82308513
115CJUN_26792858_Chip-Seq_BT549_Human0.79726913
116TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78433113
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78199089
118* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.75310150
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75039113
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.74817636
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.74817636
122UBF1/2_26484160_Chip-Seq_HMECs_Human0.74424967
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72100475
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72050733
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71882256
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71070307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.68840285
2MP0005360_urolithiasis3.62756506
3MP0005085_abnormal_gallbladder_physiolo3.50003378
4MP0010234_abnormal_vibrissa_follicle3.10116171
5MP0003191_abnormal_cellular_cholesterol3.09325271
6MP0005365_abnormal_bile_salt2.90991353
7MP0009840_abnormal_foam_cell2.67879589
8MP0008875_abnormal_xenobiotic_pharmacok2.45877155
9MP0003252_abnormal_bile_duct2.42778582
10MP0002254_reproductive_system_inflammat2.38772179
11MP0002138_abnormal_hepatobiliary_system2.28155725
12MP0003806_abnormal_nucleotide_metabolis2.08712714
13MP0000579_abnormal_nail_morphology2.06869474
14MP0008004_abnormal_stomach_pH2.05362667
15MP0010368_abnormal_lymphatic_system2.05059830
16MP0001666_abnormal_nutrient_absorption2.02177693
17MP0005167_abnormal_blood-brain_barrier1.98699715
18MP0002796_impaired_skin_barrier1.96289295
19MP0004019_abnormal_vitamin_homeostasis1.95254380
20MP0004264_abnormal_extraembryonic_tissu1.89265724
21MP0003878_abnormal_ear_physiology1.88129748
22MP0005377_hearing/vestibular/ear_phenot1.88129748
23MP0003941_abnormal_skin_development1.84175555
24MP0010329_abnormal_lipoprotein_level1.81787950
25MP0003566_abnormal_cell_adhesion1.74786273
26MP0003705_abnormal_hypodermis_morpholog1.63787728
27MP0004782_abnormal_surfactant_physiolog1.61113734
28MP0004272_abnormal_basement_membrane1.59075290
29MP0004957_abnormal_blastocyst_morpholog1.57982908
30MP0001879_abnormal_lymphatic_vessel1.57107218
31MP0005083_abnormal_biliary_tract1.51189234
32MP0002098_abnormal_vibrissa_morphology1.49788578
33MP0003453_abnormal_keratinocyte_physiol1.49386395
34MP0009643_abnormal_urine_homeostasis1.45753232
35MP0005332_abnormal_amino_acid1.45104164
36MP0010678_abnormal_skin_adnexa1.43960684
37MP0006054_spinal_hemorrhage1.42667453
38MP0000467_abnormal_esophagus_morphology1.37889799
39MP0000609_abnormal_liver_physiology1.37424160
40MP0003183_abnormal_peptide_metabolism1.36344567
41MP0000678_abnormal_parathyroid_gland1.30813150
42MP0008260_abnormal_autophagy1.26679053
43MP0003724_increased_susceptibility_to1.22647818
44MP0000383_abnormal_hair_follicle1.21913407
45MP0003195_calcinosis1.19038931
46MP0005319_abnormal_enzyme/_coenzyme1.18216991
47MP0005076_abnormal_cell_differentiation1.17370002
48MP0001730_embryonic_growth_arrest1.16990305
49MP0000858_altered_metastatic_potential1.16386874
50MP0005409_darkened_coat_color1.16385523
51MP0009053_abnormal_anal_canal1.13576924
52MP0003300_gastrointestinal_ulcer1.13155065
53MP0001756_abnormal_urination1.12915163
54MP0001216_abnormal_epidermal_layer1.12431143
55MP0003828_pulmonary_edema1.09612847
56MP0005501_abnormal_skin_physiology1.09378672
57MP0009672_abnormal_birth_weight1.08035357
58MP0000490_abnormal_crypts_of1.05979563
59MP0000537_abnormal_urethra_morphology1.05293416
60MP0003303_peritoneal_inflammation1.05283358
61MP0002118_abnormal_lipid_homeostasis1.04377536
62MP0005058_abnormal_lysosome_morphology1.03990808
63MP0001849_ear_inflammation1.01270741
64MP0005023_abnormal_wound_healing1.01131948
65MP0010771_integument_phenotype0.98919648
66MP0009931_abnormal_skin_appearance0.98590131
67MP0002060_abnormal_skin_morphology0.97937679
68MP0003890_abnormal_embryonic-extraembry0.97246079
69MP0003186_abnormal_redox_activity0.96216232
70MP0000465_gastrointestinal_hemorrhage0.95584610
71MP0002136_abnormal_kidney_physiology0.93917882
72MP0005647_abnormal_sex_gland0.91812499
73MP0010352_gastrointestinal_tract_polyps0.90165793
74MP0002132_abnormal_respiratory_system0.87867897
75MP0004947_skin_inflammation0.87505135
76MP0003984_embryonic_growth_retardation0.87403175
77MP0001672_abnormal_embryogenesis/_devel0.87279501
78MP0005380_embryogenesis_phenotype0.87279501
79MP0003693_abnormal_embryo_hatching0.87199291
80MP0005275_abnormal_skin_tensile0.85895189
81MP0005670_abnormal_white_adipose0.85203167
82MP0000598_abnormal_liver_morphology0.85164721
83MP0003718_maternal_effect0.84834263
84MP0006138_congestive_heart_failure0.84818357
85MP0002088_abnormal_embryonic_growth/wei0.84245844
86MP0010155_abnormal_intestine_physiology0.83564727
87MP0000767_abnormal_smooth_muscle0.80300443
88MP0000762_abnormal_tongue_morphology0.79919468
89MP0001542_abnormal_bone_strength0.78640331
90MP0001881_abnormal_mammary_gland0.77985271
91MP0001764_abnormal_homeostasis0.77043939
92MP0002089_abnormal_postnatal_growth/wei0.75151828
93MP0001853_heart_inflammation0.74218037
94MP0000627_abnormal_mammary_gland0.73034850
95MP0009384_cardiac_valve_regurgitation0.72907317
96MP0008469_abnormal_protein_level0.72904257
97MP0006082_CNS_inflammation0.72222557
98MP0000377_abnormal_hair_follicle0.72152200
99MP0002084_abnormal_developmental_patter0.72017137
100MP0009764_decreased_sensitivity_to0.71109583
101MP0001851_eye_inflammation0.70835516
102MP0004185_abnormal_adipocyte_glucose0.70757703
103MP0005395_other_phenotype0.70078984
104MP0005084_abnormal_gallbladder_morpholo0.69645800
105MP0005165_increased_susceptibility_to0.69513372
106MP0000343_altered_response_to0.68516314
107MP0003567_abnormal_fetal_cardiomyocyte0.67593856
108MP0001765_abnormal_ion_homeostasis0.67563643
109* MP0002080_prenatal_lethality0.67452126
110MP0003868_abnormal_feces_composition0.67373928
111MP0005666_abnormal_adipose_tissue0.66817862
112MP0005367_renal/urinary_system_phenotyp0.64412459
113MP0000516_abnormal_urinary_system0.64412459
114MP0000249_abnormal_blood_vessel0.64278472
115MP0005408_hypopigmentation0.63205030
116MP0001697_abnormal_embryo_size0.63014808
117MP0004084_abnormal_cardiac_muscle0.62974322
118MP0004883_abnormal_blood_vessel0.62884617
119MP0002085_abnormal_embryonic_tissue0.62683201
120MP0000477_abnormal_intestine_morphology0.62529783
121MP0001915_intracranial_hemorrhage0.62079795
122MP0002111_abnormal_tail_morphology0.61748548
123MP0005451_abnormal_body_composition0.61050987
124MP0003638_abnormal_response/metabolism_0.60124465
125MP0002135_abnormal_kidney_morphology0.59593087
126MP0001873_stomach_inflammation0.59452827
127MP0000566_synostosis0.59405054
128MP0005464_abnormal_platelet_physiology0.57577570
129MP0005636_abnormal_mineral_homeostasis0.57021002
130MP0001191_abnormal_skin_condition0.56236435
131MP0002697_abnormal_eye_size0.56166898
132MP0009785_altered_susceptibility_to0.55048404
133MP0005220_abnormal_exocrine_pancreas0.54908635
134MP0002086_abnormal_extraembryonic_tissu0.54749212
135MP0000367_abnormal_coat/_hair0.54744355

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.64798903
2Chronic bronchitis (HP:0004469)4.58151506
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.18773502
4Intrahepatic cholestasis (HP:0001406)3.97920212
5Onycholysis (HP:0001806)3.85223258
6Alopecia of scalp (HP:0002293)3.67432582
7Deep venous thrombosis (HP:0002625)3.60872390
8Complement deficiency (HP:0004431)3.58236269
9Esophageal varix (HP:0002040)3.52311664
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.43686908
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.39839256
12Abnormal hair laboratory examination (HP:0003328)3.37337513
13Xanthomatosis (HP:0000991)3.37015374
14Systemic lupus erythematosus (HP:0002725)3.30670834
15Abnormality of nail color (HP:0100643)3.29907315
16Hyperglycinuria (HP:0003108)3.27825655
17Gout (HP:0001997)3.25629421
18Pustule (HP:0200039)3.13571622
19Flat acetabular roof (HP:0003180)3.11761541
20Hypoglycemic coma (HP:0001325)3.11558759
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.08688793
22Hypobetalipoproteinemia (HP:0003563)3.06830547
23Thick nail (HP:0001805)3.05343058
24Hydroxyprolinuria (HP:0003080)2.94463188
25Abnormality of proline metabolism (HP:0010907)2.94463188
26Hyperglycinemia (HP:0002154)2.93794121
27Hyperammonemia (HP:0001987)2.93195635
28Plantar hyperkeratosis (HP:0007556)2.90257867
29Abnormality of the salivary glands (HP:0010286)2.84845506
30Glomerulonephritis (HP:0000099)2.75841055
31Hypolipoproteinemia (HP:0010981)2.75599595
32Vascular calcification (HP:0004934)2.74889259
33Milia (HP:0001056)2.73096786
34Fragile nails (HP:0001808)2.72918354
35Lip pit (HP:0100267)2.71523463
36Hypoalphalipoproteinemia (HP:0003233)2.70157860
37Abnormality of glycine metabolism (HP:0010895)2.68472484
38Abnormality of serine family amino acid metabolism (HP:0010894)2.68472484
39Curly hair (HP:0002212)2.68213889
40Polycythemia (HP:0001901)2.65424455
41Abnormality of complement system (HP:0005339)2.61270552
42Rhinitis (HP:0012384)2.57954034
43Fat malabsorption (HP:0002630)2.57223569
44Malnutrition (HP:0004395)2.54552283
45Abnormality of purine metabolism (HP:0004352)2.52411461
46Interstitial pulmonary disease (HP:0006530)2.51958532
47Hyperlipoproteinemia (HP:0010980)2.51913528
48Abnormality of permanent molar morphology (HP:0011071)2.49212758
49Abnormality of the dental root (HP:0006486)2.49212758
50Taurodontia (HP:0000679)2.49212758
51Bronchiectasis (HP:0002110)2.47608136
52Hematochezia (HP:0002573)2.46585196
53Ankyloglossia (HP:0010296)2.46004335
54Selective tooth agenesis (HP:0001592)2.43387698
55Cardiovascular calcification (HP:0011915)2.42913186
56Abnormality of fatty-acid metabolism (HP:0004359)2.41819123
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.41563069
58Prolonged partial thromboplastin time (HP:0003645)2.40563776
59Abnormality of the intrinsic pathway (HP:0010989)2.40450978
60Cheilitis (HP:0100825)2.40156371
61Abnormality of nucleobase metabolism (HP:0010932)2.38710531
62Abnormal respiratory motile cilium physiology (HP:0012261)2.34519612
63Nephritis (HP:0000123)2.33679778
64Woolly hair (HP:0002224)2.31410526
65Premature loss of primary teeth (HP:0006323)2.31253973
66Abnormal respiratory epithelium morphology (HP:0012253)2.29739560
67Abnormal respiratory motile cilium morphology (HP:0005938)2.29739560
68Hypoplasia of dental enamel (HP:0006297)2.26759333
69Abnormality of the dental pulp (HP:0006479)2.26533015
70Nausea (HP:0002018)2.23568826
71Absent eyelashes (HP:0000561)2.20754733
72Amelogenesis imperfecta (HP:0000705)2.19999909
73Hyperglycemia (HP:0003074)2.17301108
74Increased purine levels (HP:0004368)2.16588397
75Hyperuricemia (HP:0002149)2.16588397
76Atrophic scars (HP:0001075)2.15441832
77Hyperactive renin-angiotensin system (HP:0000841)2.14353895
78Abnormality of molar morphology (HP:0011070)2.13864659
79Abnormality of molar (HP:0011077)2.13864659
80Absent/shortened dynein arms (HP:0200106)2.13600393
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.13600393
82Focal segmental glomerulosclerosis (HP:0000097)2.13331599
83Abnormality of sulfur amino acid metabolism (HP:0004339)2.11966970
84Advanced eruption of teeth (HP:0006288)2.11620598
85Myocardial infarction (HP:0001658)2.11455962
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11380512
87Dicarboxylic aciduria (HP:0003215)2.11380512
88Abnormality of pyrimidine metabolism (HP:0004353)2.11308669
89Joint hemorrhage (HP:0005261)2.11220972
90Menorrhagia (HP:0000132)2.10223022
91Nail dystrophy (HP:0008404)2.09705645
92Conjugated hyperbilirubinemia (HP:0002908)2.09703846
93Abnormality of the common coagulation pathway (HP:0010990)2.08797420
94Abnormal blistering of the skin (HP:0008066)2.07426180
95Abnormal ciliary motility (HP:0012262)2.07378530
96Abnormality of chloride homeostasis (HP:0011422)2.06862839
97Polygenic inheritance (HP:0010982)2.05994623
98Nasal polyposis (HP:0100582)2.05806694
99Ventricular tachycardia (HP:0004756)2.03678051
100Palmoplantar hyperkeratosis (HP:0000972)2.03318303
101Unilateral renal agenesis (HP:0000122)2.02465850
102Eczematoid dermatitis (HP:0000976)2.02025557
103Rickets (HP:0002748)2.01961494
104Osteolytic defects of the hand bones (HP:0009699)1.99627643
105Osteolytic defects of the phalanges of the hand (HP:0009771)1.99627643
106Biliary tract neoplasm (HP:0100574)1.98646259
107Pili torti (HP:0003777)1.97551236
108Glomerulosclerosis (HP:0000096)1.96700032
109Steatorrhea (HP:0002570)1.95747667
110Bronchitis (HP:0012387)1.94746572
111Ketosis (HP:0001946)1.92282300
112Increased cerebral lipofuscin (HP:0011813)1.91610119
113Palmar hyperkeratosis (HP:0010765)1.91516978
114Ileus (HP:0002595)1.91478080
115Hypoplastic labia majora (HP:0000059)1.91101008
116Abnormality of the nasal mucosa (HP:0000433)1.90297599
117Hypotrichosis (HP:0001006)1.90233394
118Hypercholesterolemia (HP:0003124)1.89057762
119Pterygium (HP:0001059)1.88484060
120Vacuolated lymphocytes (HP:0001922)1.87698367
121Micronodular cirrhosis (HP:0001413)1.86625762
122Epidermoid cyst (HP:0200040)1.86461163
123Spastic diplegia (HP:0001264)1.85868960
124Proximal tubulopathy (HP:0000114)1.85037246
125Abdominal distention (HP:0003270)1.84562084
126Hepatocellular carcinoma (HP:0001402)1.84521345
127Abnormality of the lacrimal duct (HP:0011481)1.84444157
128Hypoglycemic seizures (HP:0002173)1.84345353
129Tetraparesis (HP:0002273)1.83934119
130Abnormal cartilage morphology (HP:0002763)1.83870931
131Congenital, generalized hypertrichosis (HP:0004540)1.82898996
132Abnormality of the gastric mucosa (HP:0004295)1.82693048
133Symptomatic seizures (HP:0011145)1.82021031
134Ridged nail (HP:0001807)1.81714427
135Abnormal enzyme/coenzyme activity (HP:0012379)1.81641224
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81084773
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80398353
138Increased neuronal autofluorescent lipopigment (HP:0002074)1.79973549
139Abnormality of the distal phalanges of the toes (HP:0010182)1.79598166
140Sparse eyelashes (HP:0000653)1.79591092
141Generalized aminoaciduria (HP:0002909)1.77693032
142Aortic aneurysm (HP:0004942)1.77421330
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77019609
144Hemorrhage of the eye (HP:0011885)1.76720109
145Abnormality of oral frenula (HP:0000190)1.76691984
146Blepharitis (HP:0000498)1.76364066
147Cerebral aneurysm (HP:0004944)1.75953453
148Abnormal hemoglobin (HP:0011902)1.75657074
149Gastrointestinal carcinoma (HP:0002672)1.75624383
150Malignant gastrointestinal tract tumors (HP:0006749)1.75624383
151Bronchomalacia (HP:0002780)1.74978573
152Bilateral sensorineural hearing impairment (HP:0008619)1.74805892
153Abnormality of macrophages (HP:0004311)1.74049150
154Absent eyebrow (HP:0002223)1.73761958
155Palpitations (HP:0001962)1.72526081
156Renal salt wasting (HP:0000127)1.72199762
157Neonatal death (HP:0003811)1.71900254
158Congenital ichthyosiform erythroderma (HP:0007431)1.71598975
159Abnormality of alkaline phosphatase activity (HP:0004379)1.71211813
160Abnormal vertebral ossification (HP:0100569)1.70408767
161Uterine neoplasm (HP:0010784)1.68575242
162Popliteal pterygium (HP:0009756)1.68157606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.29486119
2TGFBR23.94120455
3TIE13.16763392
4SMG12.94917329
5ERN12.84937979
6MAP3K32.67869766
7BCKDK2.58247665
8KDR2.37236472
9EEF2K2.19294889
10SIK12.16510857
11PBK2.12808538
12MAPK152.09417845
13PAK42.08627127
14LATS12.06546600
15PDK21.88898060
16MAP2K21.84406741
17MST41.81116226
18MAP2K31.78705295
19FGFR41.77744128
20TGFBR11.75990635
21PTK61.73523647
22MST1R1.72947571
23BMX1.70019676
24CDK121.58945406
25STK38L1.56229505
26FRK1.50145779
27FER1.49839167
28RPS6KB21.49409754
29NME11.47008002
30EPHB21.46565643
31IRAK31.43968174
32STK101.37139850
33RIPK11.33018461
34NEK91.24405479
35AKT31.23688570
36MYLK1.20274938
37LATS21.17877122
38PKN21.11291431
39MAP3K101.11084147
40PTK21.10274802
41RPS6KA41.08476090
42YES11.07993025
43STK31.06937760
44TYK21.05036238
45FGR1.04235197
46TRIB31.00946505
47EPHB11.00570583
48MAP3K120.96705332
49MAPKAPK30.96455888
50TSSK60.95907806
51MAP3K90.94044373
52FGFR30.92771289
53ACVR1B0.92743599
54SIK30.91405792
55MET0.88450583
56MAP3K140.87516672
57TBK10.85344336
58OXSR10.84492798
59TESK10.83374949
60MAP3K10.82724668
61RIPK40.81491049
62ALK0.80764958
63MAP3K20.75470440
64CHUK0.75217947
65BUB10.74864727
66CDK60.74639281
67MAP2K10.74295873
68PRPF4B0.73634442
69GRK10.72043787
70FGFR10.71447415
71MAP2K60.71275065
72MAP3K110.71165533
73TAOK10.71138768
74LRRK20.70673761
75MARK30.69283971
76MATK0.68298271
77FLT30.67032147
78PIK3CA0.66062781
79NUAK10.62988838
80MAP3K60.62899721
81PRKG20.62810469
82ICK0.62002782
83PIM20.59186579
84INSRR0.58977893
85STK240.58461446
86NEK60.56115733
87ZAP700.55922724
88ERBB20.55745311
89MAP3K80.55517651
90GRK70.54718649
91MAP3K130.53725992
92WEE10.53009411
93IKBKB0.52062787
94LMTK20.51000908
95STK390.50987177
96ZAK0.50950640
97TAOK30.50734293
98PIK3CG0.48348659
99MTOR0.47880699
100PRKAA20.47590598
101EPHA30.46705244
102CDC42BPA0.46507074
103GRK60.46150034
104SRPK10.45399512
105PDGFRA0.45294510
106DYRK1B0.45012594
107DYRK30.44419486
108NLK0.43756009
109TESK20.43357982
110CSK0.43224998
111EGFR0.43222574
112PAK20.42708359
113GSK3A0.42693465
114EIF2AK10.41252479
115PDPK10.41141509
116PRKCI0.40859669
117CAMK1D0.40611523
118TAF10.40153897
119TTK0.37327886
120MAPK110.37268463
121RET0.37197881
122FGFR20.37168518
123CDK70.37047382
124JAK20.35959882
125KSR20.35744174
126MAPKAPK20.35526469
127TTN0.34739947
128DMPK0.34551439
129ERBB40.32958712
130BRSK20.32232397
131BMPR1B0.32028959
132IRAK10.31769720
133AURKB0.30581102
134JAK30.30530574
135CDK40.30079654
136STK40.30043300
137RPS6KA20.30020007
138BRD40.28390610
139EIF2AK20.28176240
140IKBKE0.27952272
141NME20.26797049
142IGF1R0.26484019
143JAK10.26274939
144CSF1R0.26123727

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.91007682
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.58518925
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32693266
4Complement and coagulation cascades_Homo sapiens_hsa046102.30477166
5Fatty acid degradation_Homo sapiens_hsa000712.24265377
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12679936
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.12652578
8Nitrogen metabolism_Homo sapiens_hsa009102.12163267
9Tryptophan metabolism_Homo sapiens_hsa003802.06033085
10Vitamin digestion and absorption_Homo sapiens_hsa049772.05443888
11Arginine biosynthesis_Homo sapiens_hsa002202.04401972
12Caffeine metabolism_Homo sapiens_hsa002322.01293258
13Folate biosynthesis_Homo sapiens_hsa007901.99285825
14Chemical carcinogenesis_Homo sapiens_hsa052041.97881583
15Staphylococcus aureus infection_Homo sapiens_hsa051501.93360374
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92491701
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89371001
18Fat digestion and absorption_Homo sapiens_hsa049751.82459628
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80560444
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.80025954
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.78168085
22Histidine metabolism_Homo sapiens_hsa003401.77612112
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75882561
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.66769931
25Retinol metabolism_Homo sapiens_hsa008301.64042716
26PPAR signaling pathway_Homo sapiens_hsa033201.63883718
27Sphingolipid metabolism_Homo sapiens_hsa006001.56510133
28Sulfur metabolism_Homo sapiens_hsa009201.49463569
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.46021725
30Selenocompound metabolism_Homo sapiens_hsa004501.45284165
31beta-Alanine metabolism_Homo sapiens_hsa004101.43678607
32Peroxisome_Homo sapiens_hsa041461.37594832
33Propanoate metabolism_Homo sapiens_hsa006401.32008086
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31726513
35Glutathione metabolism_Homo sapiens_hsa004801.30758929
36Fatty acid metabolism_Homo sapiens_hsa012121.29614930
37Phenylalanine metabolism_Homo sapiens_hsa003601.25436320
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23842066
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18883044
40Steroid biosynthesis_Homo sapiens_hsa001001.17223115
41Starch and sucrose metabolism_Homo sapiens_hsa005001.14305235
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11710327
43Bile secretion_Homo sapiens_hsa049761.08570890
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07010814
45Mineral absorption_Homo sapiens_hsa049781.06590316
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06458273
47Sulfur relay system_Homo sapiens_hsa041221.00896398
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00506832
49ABC transporters_Homo sapiens_hsa020100.99383522
50Adherens junction_Homo sapiens_hsa045200.98840401
51Carbon metabolism_Homo sapiens_hsa012000.97060571
52Butanoate metabolism_Homo sapiens_hsa006500.96431215
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91597412
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91215186
55Tyrosine metabolism_Homo sapiens_hsa003500.85093370
56Arginine and proline metabolism_Homo sapiens_hsa003300.83622654
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82795211
58Notch signaling pathway_Homo sapiens_hsa043300.80398171
59Biosynthesis of amino acids_Homo sapiens_hsa012300.80377578
60Pentose phosphate pathway_Homo sapiens_hsa000300.80343024
61Galactose metabolism_Homo sapiens_hsa000520.79224079
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.78865505
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.78633538
64Other glycan degradation_Homo sapiens_hsa005110.76862314
65Lysosome_Homo sapiens_hsa041420.75289620
66N-Glycan biosynthesis_Homo sapiens_hsa005100.74906665
67Glycerolipid metabolism_Homo sapiens_hsa005610.73019806
68Legionellosis_Homo sapiens_hsa051340.72792341
69Fructose and mannose metabolism_Homo sapiens_hsa000510.72013587
70Arachidonic acid metabolism_Homo sapiens_hsa005900.71235964
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.70968986
72Vitamin B6 metabolism_Homo sapiens_hsa007500.70774305
73ECM-receptor interaction_Homo sapiens_hsa045120.70752130
74Endometrial cancer_Homo sapiens_hsa052130.70052654
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.69905313
76* Leukocyte transendothelial migration_Homo sapiens_hsa046700.69435482
77Small cell lung cancer_Homo sapiens_hsa052220.68373998
78Pyruvate metabolism_Homo sapiens_hsa006200.66740801
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65916746
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63831323
81Acute myeloid leukemia_Homo sapiens_hsa052210.62679789
82* Tight junction_Homo sapiens_hsa045300.59414349
83Chronic myeloid leukemia_Homo sapiens_hsa052200.58130102
84Antigen processing and presentation_Homo sapiens_hsa046120.58075684
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.57509799
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56169215
87Renin-angiotensin system_Homo sapiens_hsa046140.55315972
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55283674
89Lysine degradation_Homo sapiens_hsa003100.55048631
90Toxoplasmosis_Homo sapiens_hsa051450.54437063
91Linoleic acid metabolism_Homo sapiens_hsa005910.54046667
92Prostate cancer_Homo sapiens_hsa052150.52485142
93Fatty acid elongation_Homo sapiens_hsa000620.52383913
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51971331
95Proteoglycans in cancer_Homo sapiens_hsa052050.51545041
96One carbon pool by folate_Homo sapiens_hsa006700.51366079
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49993040
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49552735
99Pancreatic cancer_Homo sapiens_hsa052120.49124412
100Protein digestion and absorption_Homo sapiens_hsa049740.48791294
101Pertussis_Homo sapiens_hsa051330.46587532
102Bladder cancer_Homo sapiens_hsa052190.45223104
103Insulin signaling pathway_Homo sapiens_hsa049100.44148640
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44106391
105Prion diseases_Homo sapiens_hsa050200.43906029
106Insulin resistance_Homo sapiens_hsa049310.42798389
107Hepatitis C_Homo sapiens_hsa051600.42687821
108Hippo signaling pathway_Homo sapiens_hsa043900.42326249
109Amoebiasis_Homo sapiens_hsa051460.41981451
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41694172
111Ether lipid metabolism_Homo sapiens_hsa005650.41373997
112Renal cell carcinoma_Homo sapiens_hsa052110.40746358
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38469743
114Apoptosis_Homo sapiens_hsa042100.37673634
115TGF-beta signaling pathway_Homo sapiens_hsa043500.37614351
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36518627
117Shigellosis_Homo sapiens_hsa051310.36492307
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36076084
119Metabolic pathways_Homo sapiens_hsa011000.35908824
120p53 signaling pathway_Homo sapiens_hsa041150.34778700
121Fatty acid biosynthesis_Homo sapiens_hsa000610.33415487
122Influenza A_Homo sapiens_hsa051640.30644162
123Thyroid cancer_Homo sapiens_hsa052160.29990107
124Focal adhesion_Homo sapiens_hsa045100.29297973

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »