F10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.93687475
2L-phenylalanine catabolic process (GO:0006559)6.93687475
3L-phenylalanine metabolic process (GO:0006558)6.58981409
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.58981409
5aromatic amino acid family catabolic process (GO:0009074)6.35796408
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.26203177
7tryptophan catabolic process (GO:0006569)5.84843661
8indole-containing compound catabolic process (GO:0042436)5.84843661
9indolalkylamine catabolic process (GO:0046218)5.84843661
10kynurenine metabolic process (GO:0070189)5.62414377
11complement activation, alternative pathway (GO:0006957)5.56379347
12high-density lipoprotein particle remodeling (GO:0034375)5.54272837
13urea metabolic process (GO:0019627)5.49688891
14urea cycle (GO:0000050)5.49688891
15tryptophan metabolic process (GO:0006568)5.48638901
16bile acid biosynthetic process (GO:0006699)5.48546781
17regulation of plasminogen activation (GO:0010755)5.43724063
18negative regulation of fibrinolysis (GO:0051918)5.36907190
19glyoxylate metabolic process (GO:0046487)5.30811150
20* protein carboxylation (GO:0018214)5.22957207
21* peptidyl-glutamic acid carboxylation (GO:0017187)5.22957207
22regulation of protein activation cascade (GO:2000257)5.22694663
23regulation of fibrinolysis (GO:0051917)5.18597670
24alpha-linolenic acid metabolic process (GO:0036109)5.06498023
25nitrogen cycle metabolic process (GO:0071941)5.03686355
26intestinal cholesterol absorption (GO:0030299)5.03465647
27negative regulation of protein activation cascade (GO:2000258)4.96858265
28regulation of cholesterol esterification (GO:0010872)4.93265790
29reverse cholesterol transport (GO:0043691)4.91127273
30epoxygenase P450 pathway (GO:0019373)4.88996952
31regulation of complement activation (GO:0030449)4.88800195
32plasma lipoprotein particle remodeling (GO:0034369)4.88044622
33protein-lipid complex remodeling (GO:0034368)4.88044622
34macromolecular complex remodeling (GO:0034367)4.88044622
35sulfur amino acid catabolic process (GO:0000098)4.80733461
36cysteine metabolic process (GO:0006534)4.78124412
37phospholipid efflux (GO:0033700)4.75033477
38plasma lipoprotein particle clearance (GO:0034381)4.75027226
39regulation of triglyceride catabolic process (GO:0010896)4.70531151
40bile acid metabolic process (GO:0008206)4.67203477
41serine family amino acid catabolic process (GO:0009071)4.62023000
42exogenous drug catabolic process (GO:0042738)4.58131765
43aromatic amino acid family metabolic process (GO:0009072)4.56492913
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.49733684
45tyrosine metabolic process (GO:0006570)4.41164126
46negative regulation of blood coagulation (GO:0030195)4.36985414
47negative regulation of hemostasis (GO:1900047)4.36985414
48homocysteine metabolic process (GO:0050667)4.36811907
49triglyceride homeostasis (GO:0070328)4.36089318
50acylglycerol homeostasis (GO:0055090)4.36089318
51negative regulation of cholesterol transport (GO:0032375)4.35770138
52negative regulation of sterol transport (GO:0032372)4.35770138
53cholesterol efflux (GO:0033344)4.34404107
54aldehyde catabolic process (GO:0046185)4.29037522
55low-density lipoprotein particle remodeling (GO:0034374)4.21799514
56negative regulation of complement activation (GO:0045916)4.20712487
57alpha-amino acid catabolic process (GO:1901606)4.18245142
58amine catabolic process (GO:0009310)4.14102170
59cellular biogenic amine catabolic process (GO:0042402)4.14102170
60indolalkylamine metabolic process (GO:0006586)4.12973197
61amino-acid betaine metabolic process (GO:0006577)4.12940052
62fibrinolysis (GO:0042730)4.08811718
63negative regulation of coagulation (GO:0050819)4.06634778
64plasma lipoprotein particle assembly (GO:0034377)4.04638254
65bile acid and bile salt transport (GO:0015721)4.01009800
66imidazole-containing compound metabolic process (GO:0052803)3.98653847
67negative regulation of wound healing (GO:0061045)3.98375272
68phenylpropanoid metabolic process (GO:0009698)3.98195461
69cellular ketone body metabolic process (GO:0046950)3.95708785
70cellular glucuronidation (GO:0052695)3.91728091
71omega-hydroxylase P450 pathway (GO:0097267)3.91484014
72arginine metabolic process (GO:0006525)3.88599129
73regulation of bile acid biosynthetic process (GO:0070857)3.87576301
74lysine metabolic process (GO:0006553)3.87541240
75lysine catabolic process (GO:0006554)3.87541240
76coenzyme catabolic process (GO:0009109)3.86981276
77cofactor catabolic process (GO:0051187)3.86745462
78glycine metabolic process (GO:0006544)3.85395684
79benzene-containing compound metabolic process (GO:0042537)3.83094035
80positive regulation of triglyceride lipase activity (GO:0061365)3.82946319
81positive regulation of lipoprotein lipase activity (GO:0051006)3.82946319
82acute-phase response (GO:0006953)3.81462275
83positive regulation of lipid catabolic process (GO:0050996)3.81314629
84plasma lipoprotein particle organization (GO:0071827)3.80523848
85cellular amino acid catabolic process (GO:0009063)3.80026642
86opsonization (GO:0008228)3.79699334
87positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.79481432
88regulation of humoral immune response (GO:0002920)3.78784100
89positive regulation of blood coagulation (GO:0030194)3.76687713
90positive regulation of hemostasis (GO:1900048)3.76687713
91drug metabolic process (GO:0017144)3.76231472
92phospholipid homeostasis (GO:0055091)3.76117225
93glutamate metabolic process (GO:0006536)3.74146406
94complement activation (GO:0006956)3.71992124
95regulation of apoptotic cell clearance (GO:2000425)3.71274079
96very-low-density lipoprotein particle assembly (GO:0034379)3.70718690
97cholesterol transport (GO:0030301)3.69338182
98sterol transport (GO:0015918)3.69338182
99ethanol metabolic process (GO:0006067)3.69330405
100* protein activation cascade (GO:0072376)3.68046622
101dicarboxylic acid biosynthetic process (GO:0043650)3.67467191
102NAD biosynthetic process (GO:0009435)3.67075976
103positive regulation of coagulation (GO:0050820)3.65823861
104serine family amino acid metabolic process (GO:0009069)3.64674224
105protein-lipid complex assembly (GO:0065005)3.64000119
106cholesterol homeostasis (GO:0042632)3.63862175
107complement activation, classical pathway (GO:0006958)3.59962591
108cellular modified amino acid catabolic process (GO:0042219)3.58990073
109protein-lipid complex subunit organization (GO:0071825)3.58483279
110uronic acid metabolic process (GO:0006063)3.58398324
111glucuronate metabolic process (GO:0019585)3.58398324
112ethanol oxidation (GO:0006069)3.58257499
113sterol homeostasis (GO:0055092)3.58122513
114pyridine nucleotide biosynthetic process (GO:0019363)3.54486971
115nicotinamide nucleotide biosynthetic process (GO:0019359)3.54486971
116negative regulation of lipase activity (GO:0060192)3.51887602
117drug catabolic process (GO:0042737)3.49815085
118* blood coagulation, intrinsic pathway (GO:0007597)3.49566256
119positive regulation of fatty acid biosynthetic process (GO:0045723)3.45345263
120positive regulation of steroid metabolic process (GO:0045940)3.44904025
121lipoprotein metabolic process (GO:0042157)3.43443606
122ketone body metabolic process (GO:1902224)3.40749007
123serine family amino acid biosynthetic process (GO:0009070)3.40496876
124organic acid catabolic process (GO:0016054)3.33140383
125regulation of lipoprotein particle clearance (GO:0010984)3.31975439
126proline metabolic process (GO:0006560)3.31440330
127oxidative demethylation (GO:0070989)3.30776597
128intestinal absorption (GO:0050892)3.24699646
129heme transport (GO:0015886)3.23411004
130negative regulation of humoral immune response (GO:0002921)3.16382706
131lipid homeostasis (GO:0055088)3.13580504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.66274291
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.78033608
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.55138194
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.99945713
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.87904752
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.87703923
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.30579581
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.76028356
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.57034774
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.88874068
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.47278375
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17191221
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.11593038
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9080034
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87497651
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83626973
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71638424
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66715785
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66288594
20* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65785887
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60191869
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.49928504
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.46838437
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46651095
25HTT_18923047_ChIP-ChIP_STHdh_Human1.44115686
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43089242
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41470836
28GATA1_22025678_ChIP-Seq_K562_Human1.40283225
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40199135
30* FOXA2_19822575_ChIP-Seq_HepG2_Human1.39492093
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38062037
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30982472
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.21800124
34* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21120236
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21092436
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17313042
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15575121
38RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13087265
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10162256
40CLOCK_20551151_ChIP-Seq_293T_Human1.09707023
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07168242
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00162320
43* GATA6_25053715_ChIP-Seq_YYC3_Human0.97214999
44TCF4_18268006_ChIP-ChIP_LS174T_Human0.97034616
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93720226
46NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90370384
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90370384
48KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89249457
49NFE2_27457419_Chip-Seq_LIVER_Mouse0.89032621
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88312613
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87487753
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86713677
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86383470
54SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85830209
55SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84437532
56BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81558102
57MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81107366
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80942001
59HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80932739
60EZH2_27294783_Chip-Seq_NPCs_Mouse0.79154256
61BCAT_22108803_ChIP-Seq_LS180_Human0.78927957
62GATA4_25053715_ChIP-Seq_YYC3_Human0.78617345
63* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77714507
64RARG_19884340_ChIP-ChIP_MEFs_Mouse0.77348459
65ZNF263_19887448_ChIP-Seq_K562_Human0.76575380
66EGR1_19032775_ChIP-ChIP_M12_Human0.75901018
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75583812
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75215519
69SMAD1_18555785_Chip-Seq_ESCs_Mouse0.74875345
70PIAS1_25552417_ChIP-Seq_VCAP_Human0.74713636
71EP300_21415370_ChIP-Seq_HL-1_Mouse0.72835076
72TP53_16413492_ChIP-PET_HCT116_Human0.71859698
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.70506571
74PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70459188
75CDX2_22108803_ChIP-Seq_LS180_Human0.69871859
76ZFX_18555785_Chip-Seq_ESCs_Mouse0.69518651
77ZNF217_24962896_ChIP-Seq_MCF-7_Human0.69310287
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68596243
79ESRRB_18555785_Chip-Seq_ESCs_Mouse0.68513483
80SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68418279
81GBX2_23144817_ChIP-Seq_PC3_Human0.67950640
82NFIB_24661679_ChIP-Seq_LUNG_Mouse0.67532474
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67321372
84RUNX1_27457419_Chip-Seq_LIVER_Mouse0.66953894
85* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66951113
86ESR1_20079471_ChIP-ChIP_T-47D_Human0.66724338
87MYC_19829295_ChIP-Seq_ESCs_Human0.66215507
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66043112
89CSB_26484114_Chip-Seq_FIBROBLAST_Human0.65297414
90OCT4_18555785_Chip-Seq_ESCs_Mouse0.64760495
91* RARA_24833708_ChIP-Seq_LIVER_Mouse0.64155122
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64058383
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63826139
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.63612451
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.63490839
96TP53_18474530_ChIP-ChIP_U2OS_Human0.62986928
97STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.61898816
98SOX2_21211035_ChIP-Seq_LN229_Human0.61658775
99* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61396243
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61334289
101CEBPB_22108803_ChIP-Seq_LS180_Human0.60742799
102* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60663397
103FOXH1_21741376_ChIP-Seq_EPCs_Human0.60544382
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.60355844
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.60148145
106GATA3_24758297_ChIP-Seq_MCF-7_Human0.59548178
107ETV2_25802403_ChIP-Seq_MESCs_Mouse0.59350748
108CTCF_18555785_Chip-Seq_ESCs_Mouse0.59345209
109RAC3_21632823_ChIP-Seq_H3396_Human0.59288792
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59235115
111NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.59232002
112PU1_27457419_Chip-Seq_LIVER_Mouse0.59219524
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.58507298
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.58303784
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.57883964
116STAT1_17558387_ChIP-Seq_HELA_Human0.57291475
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57095873
118GATA2_19941826_ChIP-Seq_K562_Human0.55650993
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.54703289
120* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.54357093
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54034160
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.52946859
123MYC_19915707_ChIP-ChIP_AK7_Human0.52633506
124AR_20517297_ChIP-Seq_VCAP_Human0.52255903
125GATA1_19941826_ChIP-Seq_K562_Human0.52165662
126* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.51701762
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.51032080
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.50060620
129SOX2_20726797_ChIP-Seq_SW620_Human0.50030945
130PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49904883
131VDR_24787735_ChIP-Seq_THP-1_Human0.49496419
132PU_27001747_Chip-Seq_BMDM_Mouse0.49207064
133ESET_19884257_ChIP-Seq_ESCs_Mouse0.47608692
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.46811491
135ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.46501908
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.46077481
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.46014418
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.45692034
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.44806790
140TAF2_19829295_ChIP-Seq_ESCs_Human0.44759993
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44727308
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.44403437
143LXR_22292898_ChIP-Seq_THP-1_Human0.44329339
144E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.44259140
145* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.44130305
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44119250
147STAT4_19710469_ChIP-ChIP_TH1__Mouse0.42909974
148* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.42730346
149TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.42320538
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42285444
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41577904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.60849401
2MP0005360_urolithiasis6.92639695
3MP0005085_abnormal_gallbladder_physiolo5.78236045
4MP0005365_abnormal_bile_salt5.51375249
5MP0008875_abnormal_xenobiotic_pharmacok4.54521388
6MP0003806_abnormal_nucleotide_metabolis3.90418977
7MP0009840_abnormal_foam_cell3.53363881
8MP0003252_abnormal_bile_duct3.46110085
9MP0010329_abnormal_lipoprotein_level3.35845522
10MP0003195_calcinosis2.98806655
11MP0005083_abnormal_biliary_tract2.90224566
12MP0003191_abnormal_cellular_cholesterol2.66034687
13MP0003122_maternal_imprinting2.59900325
14MP0005332_abnormal_amino_acid2.53062316
15MP0001666_abnormal_nutrient_absorption2.29187014
16MP0009780_abnormal_chondrocyte_physiolo2.18584359
17MP0002138_abnormal_hepatobiliary_system2.10183583
18MP0000609_abnormal_liver_physiology2.09969215
19MP0004019_abnormal_vitamin_homeostasis2.04349542
20MP0002118_abnormal_lipid_homeostasis1.98151303
21MP0005319_abnormal_enzyme/_coenzyme1.82228740
22MP0005451_abnormal_body_composition1.72658058
23MP0001764_abnormal_homeostasis1.66549855
24MP0003436_decreased_susceptibility_to1.61584132
25MP0003868_abnormal_feces_composition1.58230093
26MP0009764_decreased_sensitivity_to1.56024541
27MP0003186_abnormal_redox_activity1.55903774
28MP0005584_abnormal_enzyme/coenzyme_acti1.53637635
29MP0003011_delayed_dark_adaptation1.52292829
30MP0006054_spinal_hemorrhage1.51570887
31MP0009697_abnormal_copulation1.50536482
32MP0002909_abnormal_adrenal_gland1.48014538
33MP0005379_endocrine/exocrine_gland_phen1.47510402
34MP0003656_abnormal_erythrocyte_physiolo1.45583914
35MP0003724_increased_susceptibility_to1.39670862
36MP0000604_amyloidosis1.38066099
37MP0008469_abnormal_protein_level1.33514901
38MP0003123_paternal_imprinting1.27869489
39MP0009763_increased_sensitivity_to1.25632609
40MP0009785_altered_susceptibility_to1.23734394
41MP0006082_CNS_inflammation1.20125956
42MP0009643_abnormal_urine_homeostasis1.19738451
43MP0005464_abnormal_platelet_physiology1.19401263
44MP0000598_abnormal_liver_morphology1.17012136
45MP0001915_intracranial_hemorrhage1.16051216
46MP0001835_abnormal_antigen_presentation1.10981879
47MP0002419_abnormal_innate_immunity1.09240823
48MP0002254_reproductive_system_inflammat1.08139328
49MP0005647_abnormal_sex_gland1.06687023
50MP0003879_abnormal_hair_cell1.03916413
51MP0003690_abnormal_glial_cell1.03608769
52MP0000013_abnormal_adipose_tissue1.02346922
53MP0005025_abnormal_response_to1.02290306
54MP0004272_abnormal_basement_membrane1.02161615
55MP0002837_dystrophic_cardiac_calcinosis1.00978379
56MP0003705_abnormal_hypodermis_morpholog0.97826046
57MP0003075_altered_response_to0.96189864
58MP0000566_synostosis0.93890456
59MP0005058_abnormal_lysosome_morphology0.93529253
60MP0003303_peritoneal_inflammation0.90943681
61* MP0009642_abnormal_blood_homeostasis0.90264142
62MP0001944_abnormal_pancreas_morphology0.89590368
63MP0002089_abnormal_postnatal_growth/wei0.89118660
64MP0005408_hypopigmentation0.89057855
65MP0004782_abnormal_surfactant_physiolog0.84595280
66MP0000003_abnormal_adipose_tissue0.83956444
67MP0009765_abnormal_xenobiotic_induced0.83101674
68MP0001845_abnormal_inflammatory_respons0.81985697
69MP0008438_abnormal_cutaneous_collagen0.81917687
70MP0005376_homeostasis/metabolism_phenot0.80906331
71* MP0005636_abnormal_mineral_homeostasis0.79686868
72MP0001853_heart_inflammation0.78414328
73MP0002295_abnormal_pulmonary_circulatio0.76756651
74MP0005166_decreased_susceptibility_to0.74796457
75MP0005535_abnormal_body_temperature0.74625247
76MP0002148_abnormal_hypersensitivity_rea0.73233854
77MP0002876_abnormal_thyroid_physiology0.72205272
78MP0010368_abnormal_lymphatic_system0.70470867
79MP0001533_abnormal_skeleton_physiology0.69572523
80MP0002971_abnormal_brown_adipose0.69278476
81MP0002078_abnormal_glucose_homeostasis0.68634295
82MP0005000_abnormal_immune_tolerance0.67922209
83MP0005334_abnormal_fat_pad0.67831310
84MP0003953_abnormal_hormone_level0.67391123
85MP0000685_abnormal_immune_system0.66622968
86MP0004947_skin_inflammation0.65235583
87MP0005387_immune_system_phenotype0.64948139
88MP0001790_abnormal_immune_system0.64948139
89MP0004130_abnormal_muscle_cell0.64360808
90MP0002090_abnormal_vision0.63620774
91MP0005084_abnormal_gallbladder_morpholo0.63547959
92MP0009384_cardiac_valve_regurgitation0.62569707
93MP0005187_abnormal_penis_morphology0.62451300
94MP0005670_abnormal_white_adipose0.62434133
95MP0003329_amyloid_beta_deposits0.62230585
96MP0006036_abnormal_mitochondrial_physio0.62021324
97MP0002136_abnormal_kidney_physiology0.59781672
98MP0005257_abnormal_intraocular_pressure0.57664278
99MP0005164_abnormal_response_to0.56805018
100MP0001986_abnormal_taste_sensitivity0.56752060
101MP0001800_abnormal_humoral_immune0.56661434
102MP0005551_abnormal_eye_electrophysiolog0.55769983
103MP0008873_increased_physiological_sensi0.55449905
104MP0005409_darkened_coat_color0.54363856
105MP0002723_abnormal_immune_serum0.54056390
106MP0001756_abnormal_urination0.53427920
107MP0005220_abnormal_exocrine_pancreas0.53110331
108MP0000249_abnormal_blood_vessel0.53028460
109MP0005448_abnormal_energy_balance0.52974463
110MP0010386_abnormal_urinary_bladder0.52794822
111MP0003121_genomic_imprinting0.52582837
112MP0005167_abnormal_blood-brain_barrier0.51402776
113MP0005266_abnormal_metabolism0.50900188
114MP0002938_white_spotting0.50785620
115MP0004270_analgesia0.50681874
116MP0004883_abnormal_blood_vessel0.49700221
117MP0002168_other_aberrant_phenotype0.49510283
118MP0004381_abnormal_hair_follicle0.49334212
119MP0001661_extended_life_span0.48830684
120MP0004133_heterotaxia0.48733347
121MP0005395_other_phenotype0.48340957
122MP0003633_abnormal_nervous_system0.47998623
123MP0002452_abnormal_antigen_presenting0.47502259
124MP0002163_abnormal_gland_morphology0.46071440
125MP0005646_abnormal_pituitary_gland0.45585353
126MP0000639_abnormal_adrenal_gland0.45571749
127MP0003638_abnormal_response/metabolism_0.45198588
128MP0002132_abnormal_respiratory_system0.44014270
129MP0008874_decreased_physiological_sensi0.43868852
130MP0003718_maternal_effect0.42215599
131MP0009053_abnormal_anal_canal0.42165136
132MP0002693_abnormal_pancreas_physiology0.41177664
133MP0005248_abnormal_Harderian_gland0.39933321
134MP0002928_abnormal_bile_duct0.39006903
135MP0003172_abnormal_lysosome_physiology0.37993416
136MP0001270_distended_abdomen0.37929633
137MP0003632_abnormal_nervous_system0.36846292
138MP0002933_joint_inflammation0.36524035
139MP0005023_abnormal_wound_healing0.36475969

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.11408321
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.83638371
3Intrahepatic cholestasis (HP:0001406)6.73170398
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.25278640
5* Prolonged partial thromboplastin time (HP:0003645)6.20658307
6Xanthomatosis (HP:0000991)6.01254490
7Hypobetalipoproteinemia (HP:0003563)5.79762554
8Complement deficiency (HP:0004431)5.41404402
9Hyperlipoproteinemia (HP:0010980)5.27342685
10* Joint hemorrhage (HP:0005261)4.90508132
11Recurrent gram-negative bacterial infections (HP:0005420)4.42371221
12Hypolipoproteinemia (HP:0010981)4.41450129
13Epidermoid cyst (HP:0200040)4.32955756
14Abnormality of complement system (HP:0005339)4.21052301
15* Abnormality of the common coagulation pathway (HP:0010990)4.19321685
16Hyperammonemia (HP:0001987)4.13494153
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.10923638
18Abnormality of methionine metabolism (HP:0010901)4.02508613
19Systemic lupus erythematosus (HP:0002725)3.96930574
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.96701995
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.96555894
22Hypoalphalipoproteinemia (HP:0003233)3.94699232
23Fat malabsorption (HP:0002630)3.89100522
24Abnormality of pyrimidine metabolism (HP:0004353)3.82115679
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.78312144
26Hyperglycinemia (HP:0002154)3.68272602
27Ketosis (HP:0001946)3.65079440
28Hypercholesterolemia (HP:0003124)3.61109199
29Abnormality of the intrinsic pathway (HP:0010989)3.60792271
30Conjugated hyperbilirubinemia (HP:0002908)3.45850501
31Hypoglycemic coma (HP:0001325)3.41958926
32Hyperglycinuria (HP:0003108)3.30454244
33Abnormality of glycine metabolism (HP:0010895)3.28465838
34Abnormality of serine family amino acid metabolism (HP:0010894)3.28465838
35Myocardial infarction (HP:0001658)3.28209232
36Glomerulonephritis (HP:0000099)3.25706478
37Hyperbilirubinemia (HP:0002904)3.10056358
38Steatorrhea (HP:0002570)3.02772586
39Abnormality of fatty-acid metabolism (HP:0004359)3.02543806
40Spontaneous abortion (HP:0005268)3.01508578
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.01179640
42Abnormality of nucleobase metabolism (HP:0010932)2.95358130
43Hepatocellular carcinoma (HP:0001402)2.86740934
44Amyloidosis (HP:0011034)2.73639755
45Hypochromic microcytic anemia (HP:0004840)2.68044944
46Abnormality of serum amino acid levels (HP:0003112)2.65396181
47Arthropathy (HP:0003040)2.65142927
48Vascular calcification (HP:0004934)2.64687428
49Skin nodule (HP:0200036)2.59368947
50Delayed CNS myelination (HP:0002188)2.59216517
51Purpura (HP:0000979)2.55464759
52Abnormality of purine metabolism (HP:0004352)2.51979355
53Metabolic acidosis (HP:0001942)2.47526132
54Urinary glycosaminoglycan excretion (HP:0003541)2.47078748
55Mucopolysacchariduria (HP:0008155)2.47078748
56Mitral stenosis (HP:0001718)2.45996160
57Ketoacidosis (HP:0001993)2.42299246
58* Gingival bleeding (HP:0000225)2.39301086
59Acanthocytosis (HP:0001927)2.38718441
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38402298
61Abnormality of polysaccharide metabolism (HP:0011012)2.38402298
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38402298
63Esophageal varix (HP:0002040)2.38195384
64Thrombophlebitis (HP:0004418)2.37329624
65Eczematoid dermatitis (HP:0000976)2.34817601
66Cardiovascular calcification (HP:0011915)2.31377473
67Nephritis (HP:0000123)2.30597837
68Hemorrhage of the eye (HP:0011885)2.29992919
69Abnormal gallbladder morphology (HP:0012437)2.29492625
70Abnormality of the Achilles tendon (HP:0005109)2.29130933
71Hypoglycemic seizures (HP:0002173)2.25414462
72Retinal atrophy (HP:0001105)2.25354088
73Lethargy (HP:0001254)2.24634014
74Osteomalacia (HP:0002749)2.24450137
75Pancreatitis (HP:0001733)2.23775457
76Dicarboxylic aciduria (HP:0003215)2.22932852
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22932852
78Cholelithiasis (HP:0001081)2.20303111
79Spastic diplegia (HP:0001264)2.20282975
80Irritability (HP:0000737)2.20112915
81Late onset (HP:0003584)2.15964445
82Recurrent bacterial skin infections (HP:0005406)2.13202759
83* Menorrhagia (HP:0000132)2.12603759
84Proximal tubulopathy (HP:0000114)2.11164249
85Abnormality of iron homeostasis (HP:0011031)2.10785360
86Abnormality of vitamin metabolism (HP:0100508)2.10334978
87Pulmonary embolism (HP:0002204)2.09862109
88Cerebral edema (HP:0002181)2.08978765
89Abnormal delivery (HP:0001787)2.08555979
90Sensorimotor neuropathy (HP:0007141)2.07503572
91Glycosuria (HP:0003076)2.05931475
92Abnormality of urine glucose concentration (HP:0011016)2.05931475
93Cholecystitis (HP:0001082)2.05282089
94Abnormal gallbladder physiology (HP:0012438)2.05282089
95Axonal loss (HP:0003447)2.03006046
96Vacuolated lymphocytes (HP:0001922)2.00352857
97Opisthotonus (HP:0002179)1.99710329
98Abnormality of transition element cation homeostasis (HP:0011030)1.99592825
99Neonatal onset (HP:0003623)1.98988190
100Pancreatic islet-cell hyperplasia (HP:0004510)1.98722147
101Hypophosphatemic rickets (HP:0004912)1.98301052
102Abnormality of carpal bone ossification (HP:0006257)1.97832470
103Nausea (HP:0002018)1.95044256
104Back pain (HP:0003418)1.93876621
105Hypothermia (HP:0002045)1.93624843
106Generalized aminoaciduria (HP:0002909)1.92786362
107Poikilocytosis (HP:0004447)1.91050109
108Abnormal enzyme/coenzyme activity (HP:0012379)1.90805615
109Joint swelling (HP:0001386)1.90499663
110Pigmentary retinal degeneration (HP:0001146)1.89420291
111Hydroxyprolinuria (HP:0003080)1.89318029
112Abnormality of proline metabolism (HP:0010907)1.89318029
113Hyperglycemia (HP:0003074)1.88936393
114Vomiting (HP:0002013)1.88050915
115Rickets (HP:0002748)1.87664266
116Facial shape deformation (HP:0011334)1.86212019
117Potter facies (HP:0002009)1.86212019
118Gout (HP:0001997)1.85218548
119Abnormality of the gallbladder (HP:0005264)1.84345094
120Enlarged kidneys (HP:0000105)1.83772135
121Malnutrition (HP:0004395)1.82652195
122Elevated hepatic transaminases (HP:0002910)1.80654546
123Elevated alkaline phosphatase (HP:0003155)1.80242632
124Upper motor neuron abnormality (HP:0002127)1.79906186
125Abnormal tarsal ossification (HP:0008369)1.79667177
126Renal cortical cysts (HP:0000803)1.79504670
127Fair hair (HP:0002286)1.75759353
128Hyperphosphaturia (HP:0003109)1.68039092
129Increased serum pyruvate (HP:0003542)1.64528642
130Broad alveolar ridges (HP:0000187)1.63466105
131Abnormality of the vitreous humor (HP:0004327)1.62057373
132Reduced antithrombin III activity (HP:0001976)1.59453425
133Dysostosis multiplex (HP:0000943)1.54428184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.85786622
2ERN14.10751138
3FGFR43.66714237
4TAOK33.28528201
5SIK13.27202675
6MST1R3.05189001
7MAP3K143.03007642
8PBK2.86612879
9WNK42.86014997
10TYK22.58826784
11TBK12.57199248
12ERBB42.54288036
13BLK2.39647582
14INSRR2.30659210
15IRAK32.01300452
16NTRK32.00220554
17PIK3CA1.91673515
18ABL21.88098615
19CASK1.87625574
20RIPK41.78786739
21ICK1.74738633
22MYLK1.73555257
23MAP4K21.68231428
24IKBKE1.67364098
25PDGFRA1.67083793
26AKT31.66321571
27PDK21.65655915
28JAK11.63940062
29IRAK41.61982429
30PIK3CG1.56668810
31EIF2AK11.56408950
32EPHB11.54682573
33FGFR11.51543707
34MAP2K61.48423921
35PHKG21.48364367
36PHKG11.48364367
37DAPK21.44910928
38EPHA41.43800152
39CSK1.41759029
40JAK21.40122768
41NEK91.39811540
42MAPK111.36216467
43FLT31.35651241
44MAP2K41.35580263
45PKN21.28478979
46IKBKB1.25752269
47PRKCG1.25148651
48WNK31.22129239
49MAP4K11.15860300
50NLK1.11943445
51BMX1.11858331
52MAP3K111.11777808
53MET1.11659474
54PTK61.10520654
55MAP2K31.04070082
56TRIB31.03137433
57KDR1.00232992
58FER1.00079256
59WNK10.99693997
60MUSK0.99597731
61JAK30.98651174
62EPHA30.97358311
63PTK20.96244694
64MAPKAPK30.95320868
65MAP3K20.93922300
66GRK60.93242755
67DDR20.91491139
68RET0.88410636
69TRPM70.87567690
70KIT0.86716445
71ADRBK20.85588610
72MAP3K120.85566091
73TXK0.85331811
74CSF1R0.82987661
75PRKCE0.82978507
76MAPK40.82360347
77STK38L0.82281465
78CDC42BPA0.81829587
79TYRO30.80339667
80PRKAA10.78134919
81MAP3K130.76460336
82PRKG10.75478345
83PAK30.74023650
84PRKAA20.72405480
85CSNK1D0.72362207
86ACVR1B0.71964438
87CHUK0.70872081
88PRKCZ0.70562317
89LYN0.69493219
90ERBB20.69479722
91MAP3K30.69268865
92PRKCQ0.68943533
93STK380.67441884
94PINK10.67317199
95TAOK20.67245836
96IRAK10.67140229
97CSNK1E0.66885952
98CDK120.66597274
99SGK10.64844511
100ZAP700.64078678
101TGFBR20.63777308
102BTK0.62532746
103IRAK20.62402550
104PKN10.61871761
105PRKACG0.61774004
106LATS10.61576527
107PRKD30.61015078
108SYK0.60938354
109CSNK1G10.60770997
110CAMK1D0.59872356
111MAP3K50.59846606
112MAPK120.58795027
113FRK0.56435149
114CAMK2D0.55661396
115FGFR30.55570762
116PRKACB0.55499815
117EGFR0.55437293
118STK30.55101663
119SGK2230.54792686
120SGK4940.54792686
121GSK3A0.54403914
122HCK0.54337258
123PRKG20.54332121
124MAP3K100.53633887
125PDPK10.53598569
126RIPK10.52205297
127LMTK20.52071600
128MAP3K70.51850102
129ABL10.51189361
130CDK60.51013525
131PRKACA0.50464593
132PRKCD0.49444782
133CAMK2G0.47868999
134NEK10.47749297
135RPS6KB10.45543493
136IGF1R0.45438158
137GRK10.45335405
138MST40.45211072
139MAP3K10.44583468
140SRC0.42726583
141NME20.42391654
142TIE10.42201810
143EIF2AK20.40893554
144BMPR20.39993551
145FGFR20.39782892
146AKT20.38361945
147STK240.37954565
148CSNK1A10.37939776
149LCK0.37909734
150SGK30.37451508
151PRKCB0.36718856
152RPS6KA30.36711761
153CSNK1A1L0.36337791
154LIMK10.35772160
155PIM10.35545060
156FGR0.35444611
157DYRK1B0.35267695
158PDK10.34803034
159MAPK70.33996540
160MATK0.33165274
161STK40.33036582
162TEC0.32534726
163CDK40.30000706
164MAPK150.28801935

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48820580
2Nitrogen metabolism_Homo sapiens_hsa009103.42923497
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29213598
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27448322
5* Complement and coagulation cascades_Homo sapiens_hsa046103.10557559
6Arginine biosynthesis_Homo sapiens_hsa002203.08481785
7Staphylococcus aureus infection_Homo sapiens_hsa051502.64064551
8Tryptophan metabolism_Homo sapiens_hsa003802.60013280
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54814209
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41199399
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34450514
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34395503
13Fatty acid degradation_Homo sapiens_hsa000712.30935006
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17824797
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11329721
16Peroxisome_Homo sapiens_hsa041462.09693222
17Histidine metabolism_Homo sapiens_hsa003402.03446911
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.94285304
19Chemical carcinogenesis_Homo sapiens_hsa052041.94162849
20Butanoate metabolism_Homo sapiens_hsa006501.91065311
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90713994
22PPAR signaling pathway_Homo sapiens_hsa033201.83562548
23Caffeine metabolism_Homo sapiens_hsa002321.80630898
24Retinol metabolism_Homo sapiens_hsa008301.71165492
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.70139028
26beta-Alanine metabolism_Homo sapiens_hsa004101.69330617
27Propanoate metabolism_Homo sapiens_hsa006401.66987872
28Fatty acid metabolism_Homo sapiens_hsa012121.63294153
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56288591
30Phenylalanine metabolism_Homo sapiens_hsa003601.53962916
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52019319
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47830532
33Selenocompound metabolism_Homo sapiens_hsa004501.47745801
34Steroid biosynthesis_Homo sapiens_hsa001001.45371693
35Tyrosine metabolism_Homo sapiens_hsa003501.37058931
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36490829
37Bile secretion_Homo sapiens_hsa049761.33369967
38Sulfur metabolism_Homo sapiens_hsa009201.30102180
39Starch and sucrose metabolism_Homo sapiens_hsa005001.29274050
40Fatty acid elongation_Homo sapiens_hsa000621.26933827
41ABC transporters_Homo sapiens_hsa020101.23930270
42Folate biosynthesis_Homo sapiens_hsa007901.20172206
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19045579
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17100393
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.11065426
46Pyruvate metabolism_Homo sapiens_hsa006201.08432289
47Fat digestion and absorption_Homo sapiens_hsa049751.07897689
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05895547
49Biosynthesis of amino acids_Homo sapiens_hsa012301.00340013
50Vitamin digestion and absorption_Homo sapiens_hsa049770.95223766
51Carbon metabolism_Homo sapiens_hsa012000.93718707
52Arginine and proline metabolism_Homo sapiens_hsa003300.92978134
53Sulfur relay system_Homo sapiens_hsa041220.91303283
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86211207
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.85982052
56Vitamin B6 metabolism_Homo sapiens_hsa007500.81443426
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74372735
58One carbon pool by folate_Homo sapiens_hsa006700.66668471
59Lysine degradation_Homo sapiens_hsa003100.65871778
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.65796751
61Glutathione metabolism_Homo sapiens_hsa004800.64151278
62Glycerolipid metabolism_Homo sapiens_hsa005610.59826512
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59296942
64Pentose phosphate pathway_Homo sapiens_hsa000300.58572043
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56340586
66Prion diseases_Homo sapiens_hsa050200.51142873
67Sphingolipid metabolism_Homo sapiens_hsa006000.50109734
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48937497
69Renin-angiotensin system_Homo sapiens_hsa046140.47982900
70Glucagon signaling pathway_Homo sapiens_hsa049220.47527981
71Fatty acid biosynthesis_Homo sapiens_hsa000610.43686282
72Mineral absorption_Homo sapiens_hsa049780.42256042
73Metabolic pathways_Homo sapiens_hsa011000.40204044
74N-Glycan biosynthesis_Homo sapiens_hsa005100.37438502
75Pertussis_Homo sapiens_hsa051330.28301063
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.28055099
77Linoleic acid metabolism_Homo sapiens_hsa005910.28037623
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27696286
79Galactose metabolism_Homo sapiens_hsa000520.23965746
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23933300
81Malaria_Homo sapiens_hsa051440.23508608
82Leishmaniasis_Homo sapiens_hsa051400.22514125
83Insulin resistance_Homo sapiens_hsa049310.21948839
84African trypanosomiasis_Homo sapiens_hsa051430.21897319
85Legionellosis_Homo sapiens_hsa051340.21461107
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19311516
87Fructose and mannose metabolism_Homo sapiens_hsa000510.18928130
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18288874
89Thyroid hormone synthesis_Homo sapiens_hsa049180.18258929
90Graft-versus-host disease_Homo sapiens_hsa053320.18010174
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16582014
92Ether lipid metabolism_Homo sapiens_hsa005650.16092696
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.15561783
94Circadian rhythm_Homo sapiens_hsa047100.15351103
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13359475
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.10976505
97Lysosome_Homo sapiens_hsa041420.09138092
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.07166180
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.05189336
100Protein digestion and absorption_Homo sapiens_hsa049740.04410204
101ECM-receptor interaction_Homo sapiens_hsa045120.03299963
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.02999993
103Allograft rejection_Homo sapiens_hsa053300.02344874
104Hepatitis C_Homo sapiens_hsa051600.02091502
105AMPK signaling pathway_Homo sapiens_hsa041520.01480608
106Phagosome_Homo sapiens_hsa041450.01023655
107Other glycan degradation_Homo sapiens_hsa005110.00994886
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.00320475
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.00077944
110Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0409646
111Asthma_Homo sapiens_hsa05310-0.0336487
112NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0250474
113Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0245947
114Insulin secretion_Homo sapiens_hsa04911-0.0196289
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0162395
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0134851
117Tuberculosis_Homo sapiens_hsa05152-0.0001261

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »