EZR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.27093399
2cilium or flagellum-dependent cell motility (GO:0001539)6.40787122
3motile cilium assembly (GO:0044458)5.66807948
4cilium movement (GO:0003341)5.10415754
5hepatocyte apoptotic process (GO:0097284)4.47085805
6hemidesmosome assembly (GO:0031581)4.45395393
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.35874204
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.35874204
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.34289468
10diterpenoid biosynthetic process (GO:0016102)4.29164814
11antigen processing and presentation of endogenous antigen (GO:0019883)4.28250070
12desmosome organization (GO:0002934)4.25023264
13Golgi transport vesicle coating (GO:0048200)4.23290462
14COPI coating of Golgi vesicle (GO:0048205)4.23290462
15interferon-gamma secretion (GO:0072643)4.22814504
16keratinocyte development (GO:0003334)4.21068111
17keratinocyte proliferation (GO:0043616)3.98100934
18vitamin transmembrane transport (GO:0035461)3.80565342
19epithelial cilium movement (GO:0003351)3.78301173
20ribosome assembly (GO:0042255)3.76016521
21primary alcohol catabolic process (GO:0034310)3.67705874
22bundle of His cell to Purkinje myocyte communication (GO:0086069)3.65494167
23pyrimidine-containing compound transmembrane transport (GO:0072531)3.61405735
24trophectodermal cell differentiation (GO:0001829)3.57853842
25regulation of gamma-delta T cell differentiation (GO:0045586)3.53009602
26sphingomyelin metabolic process (GO:0006684)3.50691137
27intestinal epithelial cell development (GO:0060576)3.47136895
28establishment of skin barrier (GO:0061436)3.46430373
29axoneme assembly (GO:0035082)3.32966608
30regulation of translational termination (GO:0006449)3.31741174
31positive regulation of gamma-delta T cell activation (GO:0046645)3.23511590
32activation of Rac GTPase activity (GO:0032863)3.22583280
33regulation of gamma-delta T cell activation (GO:0046643)3.18746408
34ER overload response (GO:0006983)3.17633062
35regulation of hippo signaling (GO:0035330)3.13868819
36mammary gland epithelial cell proliferation (GO:0033598)3.12705920
37calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.05816306
38positive thymic T cell selection (GO:0045059)3.05422148
39negative regulation of T cell differentiation in thymus (GO:0033085)3.04575427
40hypotonic response (GO:0006971)2.99958783
41regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.99585147
42water homeostasis (GO:0030104)2.98449027
43regulation of metalloenzyme activity (GO:0048552)2.96163843
44establishment of integrated proviral latency (GO:0075713)2.94276069
45epithelial cell-cell adhesion (GO:0090136)2.93394525
46regulation of keratinocyte differentiation (GO:0045616)2.91278503
47dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.90624849
48tolerance induction (GO:0002507)2.86640897
49viral transcription (GO:0019083)2.86416995
50positive regulation of epidermal cell differentiation (GO:0045606)2.80867541
51membrane raft organization (GO:0031579)2.78488483
52negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.77225072
53negative regulation of keratinocyte proliferation (GO:0010839)2.77176394
54gap junction assembly (GO:0016264)2.76257137
55angiotensin maturation (GO:0002003)2.76176700
56apoptotic process involved in morphogenesis (GO:0060561)2.74931951
57positive regulation of glycoprotein metabolic process (GO:1903020)2.74566162
58terpenoid biosynthetic process (GO:0016114)2.73133527
59thymic T cell selection (GO:0045061)2.72460817
60translational termination (GO:0006415)2.72326121
61cell differentiation involved in embryonic placenta development (GO:0060706)2.71026008
62cell-cell junction assembly (GO:0007043)2.70807608
63lung epithelium development (GO:0060428)2.70615565
64regulation of water loss via skin (GO:0033561)2.70521443
65regulation of interleukin-12 biosynthetic process (GO:0045075)2.69956910
66regulation of podosome assembly (GO:0071801)2.69680613
67negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.67222909
68ethanol metabolic process (GO:0006067)2.66863673
69regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.65295665
70positive regulation of glycoprotein biosynthetic process (GO:0010560)2.65176076
71cell-substrate junction assembly (GO:0007044)2.64460253
72peptide catabolic process (GO:0043171)2.63964215
73proline biosynthetic process (GO:0006561)2.63161550
74regulation of transforming growth factor beta2 production (GO:0032909)2.62314819
75regulation of chemokine secretion (GO:0090196)2.61708724
76regulation of interleukin-13 production (GO:0032656)2.60357248
77positive regulation of cytokinesis (GO:0032467)2.60317129
78nuclear pore organization (GO:0006999)2.59847808
79regulation of interleukin-5 production (GO:0032674)2.57381795
80epithelial structure maintenance (GO:0010669)2.56975804
81protein autoprocessing (GO:0016540)2.55715819
82regulation of transforming growth factor beta1 production (GO:0032908)2.54747782
83positive regulation of histone deacetylation (GO:0031065)2.52471197
84positive T cell selection (GO:0043368)2.52463031
85positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.49972404
86mitotic sister chromatid cohesion (GO:0007064)2.49920274
87nucleotide-sugar biosynthetic process (GO:0009226)2.49834416
88chemical homeostasis within a tissue (GO:0048875)2.49631503
89mesodermal cell differentiation (GO:0048333)2.49217480
90left/right pattern formation (GO:0060972)2.48561074
91notochord development (GO:0030903)2.48359749
92branching involved in labyrinthine layer morphogenesis (GO:0060670)2.47104800
93epithelial cell differentiation involved in prostate gland development (GO:0060742)2.46667761
94regulation of cardioblast differentiation (GO:0051890)2.46255299
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46018399
96maintenance of gastrointestinal epithelium (GO:0030277)2.44788275
97epidermal cell differentiation (GO:0009913)2.44739029
98natural killer cell mediated cytotoxicity (GO:0042267)2.43736902
99natural killer cell mediated immunity (GO:0002228)2.43736902
100negative T cell selection (GO:0043383)2.43591654
101positive regulation of pseudopodium assembly (GO:0031274)2.43248961
102T cell selection (GO:0045058)2.42970068
103morphogenesis of an endothelium (GO:0003159)2.41944623
104endothelial tube morphogenesis (GO:0061154)2.41944623
105actin filament depolymerization (GO:0030042)2.41758906
106positive regulation of tolerance induction (GO:0002645)2.40548253
107hippo signaling (GO:0035329)2.40363416
108nephron tubule formation (GO:0072079)2.38376377
109establishment of viral latency (GO:0019043)2.38150362
110regulation of T cell tolerance induction (GO:0002664)2.37746407
111branching involved in mammary gland duct morphogenesis (GO:0060444)2.37607306
112positive regulation of Cdc42 GTPase activity (GO:0043089)2.35532316
113negative regulation of mRNA metabolic process (GO:1903312)2.35375694
114translational elongation (GO:0006414)2.35297332
115ear development (GO:0043583)2.34334421
116activation of Rho GTPase activity (GO:0032862)2.32663168
117retinol metabolic process (GO:0042572)2.32166127
118cellular response to epidermal growth factor stimulus (GO:0071364)2.31948082
119heterochromatin organization (GO:0070828)2.31872201
120positive regulation of chromosome segregation (GO:0051984)2.31824000
121positive regulation of cell size (GO:0045793)2.31638046
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.31303995
123nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.30643927
124interferon-gamma production (GO:0032609)2.30634631
125negative regulation of humoral immune response (GO:0002921)2.30566144
126viral life cycle (GO:0019058)2.30038383
127response to laminar fluid shear stress (GO:0034616)2.29958683
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.28779220
129mitotic chromosome condensation (GO:0007076)2.28470488
130antigen processing and presentation via MHC class Ib (GO:0002475)2.28053708
131ribosomal small subunit assembly (GO:0000028)2.27925323
132negative thymic T cell selection (GO:0045060)2.27860509
133embryonic process involved in female pregnancy (GO:0060136)2.27398021
134negative regulation of execution phase of apoptosis (GO:1900118)2.27019602
135negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.26894793
136regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.26662730
137UDP-N-acetylglucosamine metabolic process (GO:0006047)2.26551049
138vitamin A metabolic process (GO:0006776)2.26270195
139positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.26255125
140negative regulation of stress fiber assembly (GO:0051497)2.25922393
141nuclear pore complex assembly (GO:0051292)2.23876503
142hormone catabolic process (GO:0042447)2.23852932
143O-glycan processing (GO:0016266)2.23298725
144glomerular visceral epithelial cell development (GO:0072015)2.22709984
145intestinal absorption (GO:0050892)2.22282154
146regulation of apoptotic process involved in morphogenesis (GO:1902337)2.21952940
147keratinocyte differentiation (GO:0030216)2.21543288
148regulation of translational fidelity (GO:0006450)2.20731123
149leukocyte aggregation (GO:0070486)2.19908155
150DNA unwinding involved in DNA replication (GO:0006268)2.19243660
151renal absorption (GO:0070293)2.18493750
152glomerular epithelial cell development (GO:0072310)2.18312071
153lymphocyte apoptotic process (GO:0070227)2.17624011
154phospholipid scrambling (GO:0017121)2.15843798
155antimicrobial humoral response (GO:0019730)2.13903180
156SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.13354416
157establishment of apical/basal cell polarity (GO:0035089)2.12849331
158positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.12626196
159surfactant homeostasis (GO:0043129)2.12372891
160ribosomal small subunit biogenesis (GO:0042274)2.11842144
161maternal placenta development (GO:0001893)2.11493088
162protein localization to endosome (GO:0036010)2.10654358
163multicellular organismal water homeostasis (GO:0050891)2.10325351
164cellular protein complex disassembly (GO:0043624)2.09949067
165T cell apoptotic process (GO:0070231)2.09430693
166tight junction assembly (GO:0070830)2.09370388
167skin morphogenesis (GO:0043589)2.08247642
168protein targeting to ER (GO:0045047)2.08125176
169regulation of T cell receptor signaling pathway (GO:0050856)2.07679243
170cell adhesion mediated by integrin (GO:0033627)2.07306798
171translational initiation (GO:0006413)2.07243318
172positive regulation of interleukin-8 secretion (GO:2000484)2.05518598
173positive regulation of actin filament depolymerization (GO:0030836)2.05333405
174RNA stabilization (GO:0043489)2.05252418
175mRNA stabilization (GO:0048255)2.05252418
176regulation of tolerance induction (GO:0002643)2.04866532
177atrioventricular valve morphogenesis (GO:0003181)2.03901784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.35925441
2E2F7_22180533_ChIP-Seq_HELA_Human4.46958349
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.57257483
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.19491729
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94671368
6MYC_22102868_ChIP-Seq_BL_Human2.68630200
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58627958
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57394757
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.45873107
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09037739
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.08501182
12* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.95137387
13VDR_21846776_ChIP-Seq_THP-1_Human1.85017436
14HIF1A_21447827_ChIP-Seq_MCF-7_Human1.83984607
15CDX2_20551321_ChIP-Seq_CACO-2_Human1.81949959
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.77624511
17SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76699823
18GATA6_25053715_ChIP-Seq_YYC3_Human1.74167564
19AR_21909140_ChIP-Seq_LNCAP_Human1.73145291
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71915258
21MAF_26560356_Chip-Seq_TH1_Human1.71061359
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.70546589
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69517716
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.69319082
25GATA3_24758297_ChIP-Seq_MCF-7_Human1.68116686
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67587751
27TCF7_22412390_ChIP-Seq_EML_Mouse1.65443817
28CLOCK_20551151_ChIP-Seq_293T_Human1.62736024
29ZNF263_19887448_ChIP-Seq_K562_Human1.62129587
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.61817555
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61591667
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.59582082
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59211002
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59064987
35* MYB_26560356_Chip-Seq_TH2_Human1.57737178
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.57427507
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.57046109
38* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56471774
39* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56471774
40ATF3_27146783_Chip-Seq_COLON_Human1.55574006
41* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54581277
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.54504913
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52356209
44* RACK7_27058665_Chip-Seq_MCF-7_Human1.51712421
45FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.47915213
46UTX_26944678_Chip-Seq_JUKART_Human1.47434846
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46359419
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45760965
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42556629
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41606912
51MYB_26560356_Chip-Seq_TH1_Human1.41288385
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.40232706
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40183648
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38825034
55GATA4_25053715_ChIP-Seq_YYC3_Human1.38563372
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37711215
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34115802
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33014416
59* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32945654
60ELF5_23300383_ChIP-Seq_T47D_Human1.32312663
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32045487
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31250398
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29487819
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29187568
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29104650
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28905518
67* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28426572
68KDM2B_26808549_Chip-Seq_DND41_Human1.27494466
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26765042
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26736717
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26348002
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26196058
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26110488
74* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25514139
75VDR_24763502_ChIP-Seq_THP-1_Human1.25251406
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23693844
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23594234
78DCP1A_22483619_ChIP-Seq_HELA_Human1.23513089
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23115392
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22741081
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20800486
82RUNX_20019798_ChIP-Seq_JUKART_Human1.20117503
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19945779
84AHR_22903824_ChIP-Seq_MCF-7_Human1.19361875
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18666424
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18523860
87* RUNX1_22412390_ChIP-Seq_EML_Mouse1.18278714
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17955645
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17104328
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16866191
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.15937792
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15330849
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14954800
94NCOR1_26117541_ChIP-Seq_K562_Human1.14632131
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13477691
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12910315
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12910315
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12910315
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11230971
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10956111
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10645340
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10609227
103MYC_18555785_ChIP-Seq_MESCs_Mouse1.09687219
104* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07822079
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07138339
106E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07052341
107P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07045685
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06762252
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05761511
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04619932
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04308131
112SOX2_20726797_ChIP-Seq_SW620_Human1.03856529
113* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02600042
114CHD1_26751641_Chip-Seq_LNCaP_Human1.02312048
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01946476
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01334357
117MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00874462
118NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00516965
119TP63_23658742_ChIP-Seq_EP156T_Human1.00044094
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99312418
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98173974
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97070519
123LXR_22292898_ChIP-Seq_THP-1_Human0.96417402
124KLF5_25053715_ChIP-Seq_YYC3_Human0.95500393
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95318410
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95281682
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94704285
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94643804
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94602487
130MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93788643
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93629834
132SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93205843
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93014616
134MAF_26560356_Chip-Seq_TH2_Human0.92885928
135* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92782549
136UBF1/2_26484160_Chip-Seq_HMECs_Human0.92263556
137ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90883068
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90514221
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89582714
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88122894
141E2F1_21310950_ChIP-Seq_MCF-7_Human0.87648759
142KDM5A_27292631_Chip-Seq_BREAST_Human0.84243827
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83915452
144FOXA1_25552417_ChIP-Seq_VCAP_Human0.81923432
145TFEB_21752829_ChIP-Seq_HELA_Human0.79842319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.38129268
2MP0010352_gastrointestinal_tract_polyps3.31783069
3MP0003300_gastrointestinal_ulcer2.78738934
4MP0004264_abnormal_extraembryonic_tissu2.63177023
5MP0002796_impaired_skin_barrier2.41553908
6MP0000537_abnormal_urethra_morphology2.31299384
7MP0003705_abnormal_hypodermis_morpholog2.25944323
8MP0001873_stomach_inflammation2.20841601
9MP0004947_skin_inflammation2.20345125
10MP0003566_abnormal_cell_adhesion2.16435972
11MP0009780_abnormal_chondrocyte_physiolo2.15086566
12MP0008057_abnormal_DNA_replication2.03189893
13MP0005076_abnormal_cell_differentiation1.97511825
14MP0003453_abnormal_keratinocyte_physiol1.96417192
15MP0010155_abnormal_intestine_physiology1.94615176
16MP0003763_abnormal_thymus_physiology1.89603053
17MP0002166_altered_tumor_susceptibility1.87347319
18MP0010678_abnormal_skin_adnexa1.83825349
19MP0005501_abnormal_skin_physiology1.83534159
20MP0002254_reproductive_system_inflammat1.77167705
21MP0000490_abnormal_crypts_of1.76676984
22MP0003866_abnormal_defecation1.74052546
23MP0004782_abnormal_surfactant_physiolog1.67735843
24MP0000685_abnormal_immune_system1.67052929
25MP0004019_abnormal_vitamin_homeostasis1.65766758
26MP0008875_abnormal_xenobiotic_pharmacok1.65049410
27MP0002006_tumorigenesis1.64778347
28MP0005023_abnormal_wound_healing1.61350700
29MP0001216_abnormal_epidermal_layer1.61279080
30MP0006054_spinal_hemorrhage1.59163768
31MP0003941_abnormal_skin_development1.49796252
32MP0003693_abnormal_embryo_hatching1.48678041
33MP0000383_abnormal_hair_follicle1.46665369
34MP0003950_abnormal_plasma_membrane1.44204956
35MP0002098_abnormal_vibrissa_morphology1.42929462
36MP0001849_ear_inflammation1.40252552
37MP0004185_abnormal_adipocyte_glucose1.36987652
38MP0004957_abnormal_blastocyst_morpholog1.36589516
39MP0000858_altered_metastatic_potential1.36144752
40MP0001790_abnormal_immune_system1.35050361
41MP0005387_immune_system_phenotype1.35050361
42MP0008004_abnormal_stomach_pH1.34454854
43MP0003303_peritoneal_inflammation1.34004084
44MP0001800_abnormal_humoral_immune1.33111506
45MP0003786_premature_aging1.31623730
46MP0003436_decreased_susceptibility_to1.29060162
47MP0009278_abnormal_bone_marrow1.28262735
48MP0001835_abnormal_antigen_presentation1.28210660
49MP0008961_abnormal_basal_metabolism1.28126371
50MP0002405_respiratory_system_inflammati1.25638355
51MP0000377_abnormal_hair_follicle1.24502563
52MP0002060_abnormal_skin_morphology1.24059885
53* MP0000477_abnormal_intestine_morphology1.22706473
54MP0010094_abnormal_chromosome_stability1.21661643
55MP0002452_abnormal_antigen_presenting1.20509618
56MP0005310_abnormal_salivary_gland1.17286253
57MP0002136_abnormal_kidney_physiology1.17022213
58MP0002396_abnormal_hematopoietic_system1.15933976
59MP0001348_abnormal_lacrimal_gland1.13505440
60MP0003718_maternal_effect1.13447811
61MP0002420_abnormal_adaptive_immunity1.12298321
62MP0010307_abnormal_tumor_latency1.12232979
63MP0002877_abnormal_melanocyte_morpholog1.12141791
64MP0001819_abnormal_immune_cell1.11758891
65MP0002398_abnormal_bone_marrow1.10823221
66MP0001666_abnormal_nutrient_absorption1.10155689
67MP0003448_altered_tumor_morphology1.08770445
68MP0001765_abnormal_ion_homeostasis1.08142227
69MP0000465_gastrointestinal_hemorrhage1.07487774
70MP0000427_abnormal_hair_cycle1.07373078
71MP0009333_abnormal_splenocyte_physiolog1.07311517
72MP0002009_preneoplasia1.06922910
73MP0000762_abnormal_tongue_morphology1.06584032
74MP0000613_abnormal_salivary_gland1.05210685
75MP0000678_abnormal_parathyroid_gland1.04385512
76MP0001663_abnormal_digestive_system1.04329938
77MP0002722_abnormal_immune_system1.03072753
78MP0005000_abnormal_immune_tolerance1.02146029
79MP0005671_abnormal_response_to1.01435285
80MP0002723_abnormal_immune_serum1.00535705
81MP0001881_abnormal_mammary_gland0.99729054
82MP0001346_abnormal_lacrimal_gland0.99344453
83MP0000350_abnormal_cell_proliferation0.98949666
84MP0000703_abnormal_thymus_morphology0.96915305
85MP0000716_abnormal_immune_system0.96865692
86MP0001845_abnormal_inflammatory_respons0.96653894
87MP0005025_abnormal_response_to0.96434894
88MP0002086_abnormal_extraembryonic_tissu0.96053782
89MP0003077_abnormal_cell_cycle0.95782158
90MP0000566_synostosis0.94611531
91MP0009643_abnormal_urine_homeostasis0.92452796
92MP0000647_abnormal_sebaceous_gland0.91418222
93MP0000689_abnormal_spleen_morphology0.90940926
94MP0000627_abnormal_mammary_gland0.90794145
95MP0002019_abnormal_tumor_incidence0.90573600
96MP0004808_abnormal_hematopoietic_stem0.90498865
97MP0005397_hematopoietic_system_phenotyp0.90213127
98MP0001545_abnormal_hematopoietic_system0.90213127
99MP0009785_altered_susceptibility_to0.90108826
100MP0010771_integument_phenotype0.90107506
101MP0003191_abnormal_cellular_cholesterol0.90085268
102MP0001730_embryonic_growth_arrest0.89135266
103MP0001191_abnormal_skin_condition0.89085869
104MP0005275_abnormal_skin_tensile0.88968315
105MP0005377_hearing/vestibular/ear_phenot0.88583133
106MP0003878_abnormal_ear_physiology0.88583133
107MP0005395_other_phenotype0.88488258
108MP0003091_abnormal_cell_migration0.88276080
109MP0001853_heart_inflammation0.88023749
110MP0000467_abnormal_esophagus_morphology0.87923557
111MP0005165_increased_susceptibility_to0.86797911
112MP0002429_abnormal_blood_cell0.86397303
113MP0009053_abnormal_anal_canal0.86388581
114MP0000579_abnormal_nail_morphology0.85971608
115MP0003943_abnormal_hepatobiliary_system0.85258184
116MP0005381_digestive/alimentary_phenotyp0.83787048
117MP0000470_abnormal_stomach_morphology0.83441215
118MP0002132_abnormal_respiratory_system0.83189271
119MP0009931_abnormal_skin_appearance0.82683434
120MP0002148_abnormal_hypersensitivity_rea0.82580061
121MP0003183_abnormal_peptide_metabolism0.82540650
122MP0001672_abnormal_embryogenesis/_devel0.82069013
123MP0005380_embryogenesis_phenotype0.82069013
124MP0002909_abnormal_adrenal_gland0.79602723
125MP0005621_abnormal_cell_physiology0.79315589
126MP0002080_prenatal_lethality0.79040859
127MP0000003_abnormal_adipose_tissue0.77454334
128MP0002138_abnormal_hepatobiliary_system0.76824842
129MP0004197_abnormal_fetal_growth/weight/0.74049338
130MP0001958_emphysema0.73964309
131MP0008058_abnormal_DNA_repair0.73901696
132MP0003111_abnormal_nucleus_morphology0.73743142
133MP0004043_abnormal_pH_regulation0.73178337
134MP0008007_abnormal_cellular_replicative0.72807003
135MP0003984_embryonic_growth_retardation0.72564173
136MP0002084_abnormal_developmental_patter0.72537787
137MP0005451_abnormal_body_composition0.70973037
138MP0001697_abnormal_embryo_size0.69803106
139MP0002088_abnormal_embryonic_growth/wei0.68464795
140MP0005248_abnormal_Harderian_gland0.67348959
141MP0000367_abnormal_coat/_hair0.67337817

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.75273622
2Abnormal respiratory motile cilium physiology (HP:0012261)6.93566798
3Chronic bronchitis (HP:0004469)6.88160103
4Rhinitis (HP:0012384)6.84670578
5Abnormal respiratory motile cilium morphology (HP:0005938)6.54480692
6Abnormal respiratory epithelium morphology (HP:0012253)6.54480692
7Abnormal ciliary motility (HP:0012262)6.31291312
8Dynein arm defect of respiratory motile cilia (HP:0012255)6.23888534
9Absent/shortened dynein arms (HP:0200106)6.23888534
10Bronchiectasis (HP:0002110)5.83942468
11Right ventricular cardiomyopathy (HP:0011663)4.18448744
12Recurrent otitis media (HP:0000403)3.63595549
13Interstitial pulmonary disease (HP:0006530)3.61571716
14Recurrent sinusitis (HP:0011108)3.60190075
15Milia (HP:0001056)3.60144648
16Onycholysis (HP:0001806)3.57544305
17Male infertility (HP:0003251)3.51157099
18Chronic sinusitis (HP:0011109)3.42240338
19Pustule (HP:0200039)3.11629565
20Pili torti (HP:0003777)3.06922214
21Glucose intolerance (HP:0000833)2.99694697
22Increased IgE level (HP:0003212)2.83863305
23Infertility (HP:0000789)2.75112858
24Fragile nails (HP:0001808)2.71167285
25Woolly hair (HP:0002224)2.70023163
26Alopecia of scalp (HP:0002293)2.62608384
27Hyperactive renin-angiotensin system (HP:0000841)2.61350611
28Autoimmune thrombocytopenia (HP:0001973)2.53151380
29Micronodular cirrhosis (HP:0001413)2.52368421
30Abnormality of the gastric mucosa (HP:0004295)2.52165475
31Biliary tract neoplasm (HP:0100574)2.49798983
32Nasal polyposis (HP:0100582)2.49692667
33Plantar hyperkeratosis (HP:0007556)2.49346971
34Rectal prolapse (HP:0002035)2.46102897
35Abnormal glucose tolerance (HP:0001952)2.44963338
36Flat acetabular roof (HP:0003180)2.44536481
37T lymphocytopenia (HP:0005403)2.41901852
38Malnutrition (HP:0004395)2.39490850
39Recurrent viral infections (HP:0004429)2.37664317
40Sparse eyelashes (HP:0000653)2.35168459
41IgM deficiency (HP:0002850)2.32780163
42Abnormality of the fingertips (HP:0001211)2.32565275
43Abnormality of chloride homeostasis (HP:0011422)2.31965396
44Short nail (HP:0001799)2.30827776
45Abnormality of T cell number (HP:0011839)2.28585330
46Abnormality of the distal phalanges of the toes (HP:0010182)2.28374727
47Atrophic scars (HP:0001075)2.23084965
48Abnormality of the nasal mucosa (HP:0000433)2.22675055
49Mesangial abnormality (HP:0001966)2.20731323
50Vascular calcification (HP:0004934)2.18389940
51Ulnar bowing (HP:0003031)2.18132939
52Progressive hearing impairment (HP:0001730)2.17789932
53Subacute progressive viral hepatitis (HP:0006572)2.16716196
54Nail dystrophy (HP:0008404)2.16058676
55Abnormal foot bone ossification (HP:0010675)2.14685684
56Recurrent fungal infections (HP:0002841)2.13151694
57Ureteral stenosis (HP:0000071)2.12112533
58Renal salt wasting (HP:0000127)2.10760704
59Chronic otitis media (HP:0000389)2.10650878
60Abnormality of the dental root (HP:0006486)2.10364122
61Taurodontia (HP:0000679)2.10364122
62Abnormality of permanent molar morphology (HP:0011071)2.10364122
63Lip pit (HP:0100267)2.09837520
64Recurrent bronchitis (HP:0002837)2.09566769
65Blepharitis (HP:0000498)2.09262663
66Cone-rod dystrophy (HP:0000548)2.06708006
67Malignant gastrointestinal tract tumors (HP:0006749)2.03665907
68Gastrointestinal carcinoma (HP:0002672)2.03665907
69Focal segmental glomerulosclerosis (HP:0000097)2.02785137
70Dehydration (HP:0001944)2.02702174
71Curly hair (HP:0002212)2.02212920
72Palmoplantar hyperkeratosis (HP:0000972)2.01634173
73Posterior subcapsular cataract (HP:0007787)2.01074116
74Abnormal vertebral ossification (HP:0100569)2.00921431
75Distal lower limb muscle weakness (HP:0009053)1.97778264
76Reticulocytopenia (HP:0001896)1.96829177
77Ureteral obstruction (HP:0006000)1.96292129
78Progressive sensorineural hearing impairment (HP:0000408)1.94651549
79Selective tooth agenesis (HP:0001592)1.94417534
80Abnormality of nail color (HP:0100643)1.93922933
81B lymphocytopenia (HP:0010976)1.92516543
82Abnormality of B cell number (HP:0010975)1.92516543
83Entropion (HP:0000621)1.92459503
84Hematochezia (HP:0002573)1.91401802
85Esophageal atresia (HP:0002032)1.91320293
86Palmar hyperkeratosis (HP:0010765)1.90069175
87Eczematoid dermatitis (HP:0000976)1.89993659
88Combined immunodeficiency (HP:0005387)1.88402517
89Hyponatremia (HP:0002902)1.88103692
90Abnormal hair laboratory examination (HP:0003328)1.87144813
91Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84448688
92Aortic aneurysm (HP:0004942)1.83951080
93Diaphragmatic weakness (HP:0009113)1.83664717
94Gastrointestinal inflammation (HP:0004386)1.82677580
95Inflammation of the large intestine (HP:0002037)1.82618793
96Trismus (HP:0000211)1.82456201
97Abnormality of the dental pulp (HP:0006479)1.82442700
98Vertebral hypoplasia (HP:0008417)1.82296673
99Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82296673
100Abnormality of molar morphology (HP:0011070)1.81808791
101Abnormality of molar (HP:0011077)1.81808791
102Autoimmune hemolytic anemia (HP:0001890)1.81591893
103Verrucae (HP:0200043)1.80624257
104Papilloma (HP:0012740)1.80624257
105IgA deficiency (HP:0002720)1.78590956
106Cardiovascular calcification (HP:0011915)1.78471359
107Hyperaldosteronism (HP:0000859)1.77331025
108Hypoalbuminemia (HP:0003073)1.77264586
109Abnormal albumin level (HP:0012116)1.77264586
110Deviation of the thumb (HP:0009603)1.77164640
111Natal tooth (HP:0000695)1.76551853
112Abnormality of T cells (HP:0002843)1.76140838
113Abnormal blistering of the skin (HP:0008066)1.76096990
114Skin ulcer (HP:0200042)1.76030284
115Abnormality of small intestinal villus morphology (HP:0011472)1.75476421
116Villous atrophy (HP:0011473)1.75476421
117Colitis (HP:0002583)1.73886515
118Uterine neoplasm (HP:0010784)1.73305842
119Thick nail (HP:0001805)1.73001469
120Glomerulosclerosis (HP:0000096)1.72832320
121Abnormality of the salivary glands (HP:0010286)1.72468723
122Eosinophilia (HP:0001880)1.72100636
123Cellulitis (HP:0100658)1.71424815
124Lymphopenia (HP:0001888)1.70866121
125Abnormality of cells of the lymphoid lineage (HP:0012140)1.70482297
126Chronic diarrhea (HP:0002028)1.70296815
127Abdominal distention (HP:0003270)1.70110310
128Atelectasis (HP:0100750)1.69591718
129Abnormality of cells of the erythroid lineage (HP:0012130)1.68714502
130Hypoplasia of dental enamel (HP:0006297)1.68673336
131Hyperkalemia (HP:0002153)1.68624129
132Abnormality of proline metabolism (HP:0010907)1.68500607
133Hydroxyprolinuria (HP:0003080)1.68500607
134Aplasia cutis congenita (HP:0001057)1.67822172
135Abnormal hemoglobin (HP:0011902)1.67682537
136Persistence of primary teeth (HP:0006335)1.67474960
137Increased density of long bones (HP:0006392)1.65928585
138Progressive external ophthalmoplegia (HP:0000590)1.65752215
139Colon cancer (HP:0003003)1.65055685
140Metaphyseal cupping (HP:0003021)1.64445833
141Emphysema (HP:0002097)1.62408753
142Severe combined immunodeficiency (HP:0004430)1.62112720
143Abnormal tarsal ossification (HP:0008369)1.61176463
144Popliteal pterygium (HP:0009756)1.61107114
145Bronchitis (HP:0012387)1.61015910
146Esophageal varix (HP:0002040)1.60850365
147Occipital encephalocele (HP:0002085)1.60309623
148Abnormality of renin-angiotensin system (HP:0000847)1.59831249
149Elevated erythrocyte sedimentation rate (HP:0003565)1.59749057
150Abnormal biliary tract morphology (HP:0012440)1.59693256
151Abnormality of monocarboxylic acid metabolism (HP:0010996)1.59021138
152Osteolytic defects of the hand bones (HP:0009699)1.58663128
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.58663128
154Thrombocytosis (HP:0001894)1.57581692
155Decreased circulating renin level (HP:0003351)1.56754444
156Advanced eruption of teeth (HP:0006288)1.55701276
157Gastrointestinal stroma tumor (HP:0100723)1.55204164
158Subcapsular cataract (HP:0000523)1.55047959
159Erythema (HP:0010783)1.54443787
160Palpitations (HP:0001962)1.54256656
161Congenital ichthyosiform erythroderma (HP:0007431)1.53773606
162Bronchomalacia (HP:0002780)1.50498118
163Hypotrichosis (HP:0001006)1.48107702
164Ureteral duplication (HP:0000073)1.46838660
165Tubular atrophy (HP:0000092)1.45569093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.04498390
2EEF2K2.93850274
3MAP4K12.88349128
4MAPK152.79165591
5MAP3K102.58998051
6RPS6KB22.48271525
7TRIB32.44421988
8ERN12.38137594
9GRK62.36631026
10SMG12.33260258
11PBK2.30639932
12TSSK62.30015270
13CDK122.20543734
14PKN22.17137415
15MAP3K122.13328060
16EIF2AK32.12981614
17PTK62.08599085
18SIK31.90969479
19MAP3K31.89354183
20FRK1.85846767
21* STK101.78287262
22MST1R1.70867129
23BUB11.69042987
24BRSK21.60092348
25MAPKAPK31.51807524
26LMTK21.51527206
27MAP2K21.50952297
28EPHB11.50326159
29EIF2AK11.49068683
30BCR1.47496614
31TESK11.46199334
32PAK41.45726321
33* LRRK21.40915224
34RIPK11.39549067
35WEE11.36393825
36JAK31.33548793
37NME11.33361045
38TTN1.28102106
39ZAP701.27870533
40ITK1.26570162
41RPS6KA41.25542872
42TYK21.24680167
43MAP3K21.19349186
44STK38L1.19269939
45FER1.14234824
46CSK1.12866956
47TRIM281.11654935
48SCYL21.10094033
49TESK21.10078746
50FGFR41.09135930
51CDK61.08106012
52LATS11.07994772
53PRKG21.04701980
54TBK11.04399184
55MAP3K141.03453128
56SIK11.02982180
57TRPM71.01476323
58BTK1.00610282
59BMPR20.99845806
60FGFR30.99374258
61PIM10.98135778
62NEK60.96714545
63NLK0.94581118
64TGFBR20.94189700
65PTK20.94045302
66ERBB40.93095247
67ERBB30.92975684
68CHUK0.92654384
69NEK20.84727485
70BMX0.83120987
71TAOK10.82157813
72ICK0.81134269
73MAP2K30.80132691
74AURKB0.80066337
75BLK0.78359078
76MAP3K70.78001583
77BRD40.77006599
78JAK10.76433910
79MET0.72846955
80ALK0.72684720
81EPHB20.72265493
82MAP3K110.71846520
83CDK40.71501408
84STK30.70379971
85* MAP3K80.69818600
86STK40.69012136
87MELK0.69003453
88MARK30.67436450
89IKBKE0.66056948
90MATK0.64392452
91CDK70.64257272
92TXK0.62870478
93BRSK10.62805000
94PDGFRB0.62060537
95OXSR10.61475913
96IKBKB0.61461305
97DMPK0.61198822
98TGFBR10.60938621
99PAK20.60019551
100MAPKAPK20.59961739
101STK240.58813223
102DYRK1B0.58187801
103MAP3K90.57795553
104LATS20.57554175
105PLK10.55565925
106* PRKCI0.55354070
107MTOR0.55293591
108CDK90.53140583
109PDGFRA0.52315283
110PASK0.51583315
111HCK0.50853133
112NME20.49756534
113JAK20.49749490
114FLT30.48797655
115NEK10.48612408
116SRPK10.48333361
117STK390.48165101
118IRAK30.48124878
119CHEK10.47425597
120MYLK0.47419724
121RPS6KA10.46423311
122TTK0.44850595
123CDC70.43866350
124PIM20.43209324
125FGFR10.42775585
126WNK40.42721062
127STK380.42311934
128* LCK0.42062272
129CSF1R0.41696609
130* MST40.41437961
131TNIK0.40886254
132NEK90.40608709
133DAPK10.38799594
134MKNK20.37959388
135EPHA30.37041713
136MAPK110.36980873
137EIF2AK20.36775506
138SYK0.36071089
139CDK80.35711522
140TEC0.35169653
141MAP3K130.33795338
142ILK0.28475904
143HIPK20.26486215
144YES10.25591068

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.33997174
2Phenylalanine metabolism_Homo sapiens_hsa003602.21676409
3Proteasome_Homo sapiens_hsa030502.10975963
4Histidine metabolism_Homo sapiens_hsa003401.99536087
5Small cell lung cancer_Homo sapiens_hsa052221.97876825
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96250713
7Sphingolipid metabolism_Homo sapiens_hsa006001.95120366
8Antigen processing and presentation_Homo sapiens_hsa046121.90984116
9Adherens junction_Homo sapiens_hsa045201.90503609
10Renin-angiotensin system_Homo sapiens_hsa046141.89106285
11* Leukocyte transendothelial migration_Homo sapiens_hsa046701.88157801
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87866399
13Fructose and mannose metabolism_Homo sapiens_hsa000511.72087009
14Mineral absorption_Homo sapiens_hsa049781.71985208
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61226497
16Thyroid cancer_Homo sapiens_hsa052161.58339615
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56954979
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56494241
19Hematopoietic cell lineage_Homo sapiens_hsa046401.55409393
20Toxoplasmosis_Homo sapiens_hsa051451.54261135
21Bladder cancer_Homo sapiens_hsa052191.53423123
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.50505055
23Chronic myeloid leukemia_Homo sapiens_hsa052201.48126107
24B cell receptor signaling pathway_Homo sapiens_hsa046621.47247884
25Leishmaniasis_Homo sapiens_hsa051401.42597241
26T cell receptor signaling pathway_Homo sapiens_hsa046601.37993165
27* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37734248
28Acute myeloid leukemia_Homo sapiens_hsa052211.35140562
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33614833
30Pentose phosphate pathway_Homo sapiens_hsa000301.32124989
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31492929
32Vitamin B6 metabolism_Homo sapiens_hsa007501.30409943
33Viral myocarditis_Homo sapiens_hsa054161.28032620
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27386433
35Chemical carcinogenesis_Homo sapiens_hsa052041.27183479
36Tight junction_Homo sapiens_hsa045301.25995376
37Apoptosis_Homo sapiens_hsa042101.25898452
38Measles_Homo sapiens_hsa051621.21484216
39Osteoclast differentiation_Homo sapiens_hsa043801.21381779
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.18510226
41Tyrosine metabolism_Homo sapiens_hsa003501.16497950
42p53 signaling pathway_Homo sapiens_hsa041151.16092658
43Pancreatic cancer_Homo sapiens_hsa052121.15811747
44ECM-receptor interaction_Homo sapiens_hsa045121.15325771
45Ribosome_Homo sapiens_hsa030101.14804577
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14648443
47Nucleotide excision repair_Homo sapiens_hsa034201.13760520
48Folate biosynthesis_Homo sapiens_hsa007901.13481453
49Shigellosis_Homo sapiens_hsa051311.12129998
50* Proteoglycans in cancer_Homo sapiens_hsa052051.11552356
51DNA replication_Homo sapiens_hsa030301.10591925
52Hippo signaling pathway_Homo sapiens_hsa043901.10521177
53mRNA surveillance pathway_Homo sapiens_hsa030151.10264291
54Legionellosis_Homo sapiens_hsa051341.10046933
55Caffeine metabolism_Homo sapiens_hsa002321.09509796
56Endometrial cancer_Homo sapiens_hsa052131.09310464
57Protein digestion and absorption_Homo sapiens_hsa049741.09193053
58Fat digestion and absorption_Homo sapiens_hsa049751.07318368
59HTLV-I infection_Homo sapiens_hsa051661.07162963
60Focal adhesion_Homo sapiens_hsa045101.06845010
61Herpes simplex infection_Homo sapiens_hsa051681.06148400
62Circadian rhythm_Homo sapiens_hsa047101.06063179
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05740451
64Viral carcinogenesis_Homo sapiens_hsa052031.05299342
65* MicroRNAs in cancer_Homo sapiens_hsa052061.04681425
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.04518421
67Hepatitis C_Homo sapiens_hsa051601.03748287
68Influenza A_Homo sapiens_hsa051641.02976734
69TNF signaling pathway_Homo sapiens_hsa046681.01998190
70Jak-STAT signaling pathway_Homo sapiens_hsa046301.00851180
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99358158
72Hepatitis B_Homo sapiens_hsa051610.97578685
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95073618
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94523401
75Colorectal cancer_Homo sapiens_hsa052100.94067173
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93287328
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90869339
78Galactose metabolism_Homo sapiens_hsa000520.88682963
79Prostate cancer_Homo sapiens_hsa052150.88046132
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87871171
81Salmonella infection_Homo sapiens_hsa051320.85650386
82Vitamin digestion and absorption_Homo sapiens_hsa049770.84384809
83Non-small cell lung cancer_Homo sapiens_hsa052230.83986519
84Notch signaling pathway_Homo sapiens_hsa043300.83808133
85Amoebiasis_Homo sapiens_hsa051460.83034578
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82654647
87N-Glycan biosynthesis_Homo sapiens_hsa005100.81321061
88VEGF signaling pathway_Homo sapiens_hsa043700.80362268
89Pathways in cancer_Homo sapiens_hsa052000.79428330
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.78745097
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78313314
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78209059
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78009305
94Starch and sucrose metabolism_Homo sapiens_hsa005000.76944115
95Mismatch repair_Homo sapiens_hsa034300.76407162
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75954746
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75935410
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75533787
99* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75322905
100Sulfur metabolism_Homo sapiens_hsa009200.74930704
101Retinol metabolism_Homo sapiens_hsa008300.74425732
102Glutathione metabolism_Homo sapiens_hsa004800.73831787
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73176601
104Arginine biosynthesis_Homo sapiens_hsa002200.72836368
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72518870
106Other glycan degradation_Homo sapiens_hsa005110.72515648
107Cell cycle_Homo sapiens_hsa041100.70089623
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69995290
109TGF-beta signaling pathway_Homo sapiens_hsa043500.69485908
110Autoimmune thyroid disease_Homo sapiens_hsa053200.68074406
111Spliceosome_Homo sapiens_hsa030400.67730308
112Basal cell carcinoma_Homo sapiens_hsa052170.65825610
113Platelet activation_Homo sapiens_hsa046110.65018552
114Pyrimidine metabolism_Homo sapiens_hsa002400.64039590
115Arginine and proline metabolism_Homo sapiens_hsa003300.63490035
116Biosynthesis of amino acids_Homo sapiens_hsa012300.63313847
117mTOR signaling pathway_Homo sapiens_hsa041500.63164020
118Tuberculosis_Homo sapiens_hsa051520.62990431
119Inositol phosphate metabolism_Homo sapiens_hsa005620.62784148
120Base excision repair_Homo sapiens_hsa034100.62725550
121Selenocompound metabolism_Homo sapiens_hsa004500.62724360
122HIF-1 signaling pathway_Homo sapiens_hsa040660.62587075
123Renal cell carcinoma_Homo sapiens_hsa052110.62410406
124Epstein-Barr virus infection_Homo sapiens_hsa051690.62362520
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.61638640
126Non-homologous end-joining_Homo sapiens_hsa034500.59079673
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58766497
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58362280
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58242734
130Endocytosis_Homo sapiens_hsa041440.58161932
131Prolactin signaling pathway_Homo sapiens_hsa049170.57813445
132beta-Alanine metabolism_Homo sapiens_hsa004100.56860590
133Pertussis_Homo sapiens_hsa051330.56455675
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56320459
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55763113
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.55220116
137RNA degradation_Homo sapiens_hsa030180.54941893
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.53153181
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52818667
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52678177
141Vibrio cholerae infection_Homo sapiens_hsa051100.52246413
142FoxO signaling pathway_Homo sapiens_hsa040680.51339442
143RNA transport_Homo sapiens_hsa030130.50755847
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50104959
145Allograft rejection_Homo sapiens_hsa053300.49929005
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.49690956
147Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47497840

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