EYA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.40874520
2cilium or flagellum-dependent cell motility (GO:0001539)7.40401957
3cilium movement (GO:0003341)7.06506777
4definitive hemopoiesis (GO:0060216)6.84618228
5ribosomal small subunit assembly (GO:0000028)6.60251961
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.37368932
7motile cilium assembly (GO:0044458)6.15600613
8ganglion development (GO:0061548)5.93635368
9epithelial cilium movement (GO:0003351)5.87355174
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.28897104
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.28897104
12sequestering of actin monomers (GO:0042989)4.81607358
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.81526857
14left/right pattern formation (GO:0060972)4.76439849
15antigen processing and presentation of endogenous antigen (GO:0019883)4.74620666
16negative regulation of erythrocyte differentiation (GO:0045647)4.58671218
17establishment of planar polarity (GO:0001736)4.45223078
18establishment of tissue polarity (GO:0007164)4.45223078
19cell migration in hindbrain (GO:0021535)4.40394628
20planar cell polarity pathway involved in neural tube closure (GO:0090179)4.31554831
21lung epithelium development (GO:0060428)4.27322640
22platelet dense granule organization (GO:0060155)4.27308182
23viral transcription (GO:0019083)4.24679445
24antigen processing and presentation via MHC class Ib (GO:0002475)4.14538520
25hepatocyte apoptotic process (GO:0097284)4.09352414
26megakaryocyte development (GO:0035855)4.05376725
27negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.99073621
28axoneme assembly (GO:0035082)3.98635482
29translational termination (GO:0006415)3.98397786
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.94028965
31negative regulation of transcription regulatory region DNA binding (GO:2000678)3.84873038
32establishment or maintenance of monopolar cell polarity (GO:0061339)3.83205777
33establishment of monopolar cell polarity (GO:0061162)3.83205777
34dosage compensation (GO:0007549)3.83014783
35microtubule bundle formation (GO:0001578)3.72506051
36negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.66725738
37establishment of apical/basal cell polarity (GO:0035089)3.56163262
38translational elongation (GO:0006414)3.55537138
39centriole replication (GO:0007099)3.54177380
40regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.53127618
41Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.50235687
42hemidesmosome assembly (GO:0031581)3.46792657
43apical protein localization (GO:0045176)3.46132966
44protein retention in ER lumen (GO:0006621)3.42749510
45ear development (GO:0043583)3.40298886
46ribosomal small subunit biogenesis (GO:0042274)3.39922490
47camera-type eye morphogenesis (GO:0048593)3.39061292
48regulation of respiratory burst (GO:0060263)3.35921372
49positive regulation of gamma-delta T cell activation (GO:0046645)3.33085374
50regulation of establishment of planar polarity (GO:0090175)3.30929471
51ventricular system development (GO:0021591)3.30025926
52eyelid development in camera-type eye (GO:0061029)3.28630573
53barbed-end actin filament capping (GO:0051016)3.27969307
54lymphoid progenitor cell differentiation (GO:0002320)3.26825282
55positive regulation of respiratory burst (GO:0060267)3.25958597
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25765920
57negative regulation of glial cell proliferation (GO:0060253)3.23994638
58lateral sprouting from an epithelium (GO:0060601)3.23596864
59glial cell proliferation (GO:0014009)3.21661723
60multicellular organismal water homeostasis (GO:0050891)3.20401943
61cotranslational protein targeting to membrane (GO:0006613)3.19715948
62response to interferon-beta (GO:0035456)3.19471870
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19471747
64sympathetic nervous system development (GO:0048485)3.18905555
65protein targeting to ER (GO:0045047)3.18515630
66mature B cell differentiation involved in immune response (GO:0002313)3.18334323
67diterpenoid biosynthetic process (GO:0016102)3.17352221
68intraciliary transport (GO:0042073)3.16358105
69desmosome organization (GO:0002934)3.15936756
70primary alcohol catabolic process (GO:0034310)3.11831140
71protein-DNA complex disassembly (GO:0032986)3.10156998
72nucleosome disassembly (GO:0006337)3.10156998
73phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.08999606
74viral life cycle (GO:0019058)3.07268696
75neural tube formation (GO:0001841)3.06563117
76homeostasis of number of cells within a tissue (GO:0048873)3.05566522
77regulation of secondary heart field cardioblast proliferation (GO:0003266)3.04096682
78regulation of cardioblast proliferation (GO:0003264)3.04096682
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03545437
80mesodermal cell differentiation (GO:0048333)3.03161137
81establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02737681
82response to interferon-alpha (GO:0035455)3.01835953
83neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.00746606
84substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.99701397
85substrate-independent telencephalic tangential migration (GO:0021826)2.99701397
86protein localization to endoplasmic reticulum (GO:0070972)2.99505302
87maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99403788
88mucosal-associated lymphoid tissue development (GO:0048537)2.98778512
89Peyers patch development (GO:0048541)2.98778512
90semaphorin-plexin signaling pathway (GO:0071526)2.98447554
91response to protozoan (GO:0001562)2.93746887
92centriole assembly (GO:0098534)2.93229834
93embryonic hemopoiesis (GO:0035162)2.93030967
94T cell differentiation in thymus (GO:0033077)2.90408634
95angiogenesis involved in wound healing (GO:0060055)2.90124500
96establishment or maintenance of apical/basal cell polarity (GO:0035088)2.89376015
97establishment or maintenance of bipolar cell polarity (GO:0061245)2.89376015
98regulation of natural killer cell differentiation (GO:0032823)2.86309306
99positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.85937093
100positive regulation of cell cycle G2/M phase transition (GO:1902751)2.85937093
101cellular protein complex disassembly (GO:0043624)2.85795931
102protein complex disassembly (GO:0043241)2.85209814
103paraxial mesoderm development (GO:0048339)2.83890979
104dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83486900
105T cell differentiation (GO:0030217)2.82293332
106positive regulation of smoothened signaling pathway (GO:0045880)2.82249110
107detection of bacterium (GO:0016045)2.82109146
108behavioral response to nicotine (GO:0035095)2.81322997
109asymmetric protein localization (GO:0008105)2.80799916
110hematopoietic stem cell differentiation (GO:0060218)2.79118258
111enteric nervous system development (GO:0048484)2.77950172
112T cell homeostasis (GO:0043029)2.77862393
113positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.77648718
114lymph node development (GO:0048535)2.76275006
115cilium assembly (GO:0042384)2.74954935
116negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.74738355
117negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.74011847
118regulation of gamma-delta T cell differentiation (GO:0045586)2.73301010
119regulation of cilium movement (GO:0003352)2.73013113
120secretory granule organization (GO:0033363)2.72290321
121cilium organization (GO:0044782)2.72242469
122macromolecular complex disassembly (GO:0032984)2.71740263
123phospholipid scrambling (GO:0017121)2.71450987
124left/right axis specification (GO:0070986)2.70971234
125negative regulation of phagocytosis (GO:0050765)2.70805075
126germ cell migration (GO:0008354)2.70356578
127blood vessel maturation (GO:0001955)2.70089088
128positive regulation of T cell mediated cytotoxicity (GO:0001916)2.69802491
129regulation of gamma-delta T cell activation (GO:0046643)2.69294206
130vitamin transmembrane transport (GO:0035461)2.68652061
131non-canonical Wnt signaling pathway (GO:0035567)2.67175714
132glucocorticoid receptor signaling pathway (GO:0042921)2.66769952
133maturation of SSU-rRNA (GO:0030490)2.66502756
134negative regulation of epidermal cell differentiation (GO:0045605)2.64921203
135regulation of chromatin binding (GO:0035561)2.64214337
136regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.63211745
137regulation of RIG-I signaling pathway (GO:0039535)2.62087215
138microtubule-based movement (GO:0007018)2.61629262
139water homeostasis (GO:0030104)2.61524648
140regulation of NFAT protein import into nucleus (GO:0051532)2.61512347
141cochlea morphogenesis (GO:0090103)2.60870742
142cranial nerve morphogenesis (GO:0021602)2.60469539
143nodal signaling pathway (GO:0038092)2.60156243
144lens morphogenesis in camera-type eye (GO:0002089)2.60082237
145neuron projection extension involved in neuron projection guidance (GO:1902284)2.59806685
146axon extension involved in axon guidance (GO:0048846)2.59806685
147cornea development in camera-type eye (GO:0061303)2.59634386
148face development (GO:0060324)2.57924652
149detection of other organism (GO:0098543)2.57697389
150regulation of glial cell proliferation (GO:0060251)2.57331308
151interferon-gamma secretion (GO:0072643)2.53399714
152mesenchyme development (GO:0060485)2.52306283
153positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.51849799
154stress granule assembly (GO:0034063)2.51164931
155regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.50982967
156facial nerve structural organization (GO:0021612)2.50872476
157surfactant homeostasis (GO:0043129)2.49803642
158production of molecular mediator of immune response (GO:0002440)2.49562856
159cytokine production involved in immune response (GO:0002367)2.49206879
160negative regulation of epidermis development (GO:0045683)2.48170770
161axonal fasciculation (GO:0007413)2.47521380
162negative regulation of glycoprotein biosynthetic process (GO:0010561)2.46735430
163epithelial cell maturation (GO:0002070)2.46720511
164regulation of necroptotic process (GO:0060544)2.46561617
165positive regulation of granulocyte differentiation (GO:0030854)2.46514455
166leukocyte aggregation (GO:0070486)2.46213286
167snRNA transcription (GO:0009301)2.44308669
168regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.44238303
169one-carbon compound transport (GO:0019755)2.42269980
170chemical homeostasis within a tissue (GO:0048875)2.40175557
171regulation of water loss via skin (GO:0033561)2.39836482
172ethanol metabolic process (GO:0006067)2.38788056
173neuronal ion channel clustering (GO:0045161)2.37030414
174eye morphogenesis (GO:0048592)2.36446298
175embryonic body morphogenesis (GO:0010172)2.36362696
176embryonic camera-type eye development (GO:0031076)2.35291003
177prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.34322938
178G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32702882
179cellular component assembly involved in morphogenesis (GO:0010927)2.31404566
180establishment of skin barrier (GO:0061436)2.30753833
181endothelial cell chemotaxis (GO:0035767)2.30727874
182lens fiber cell development (GO:0070307)2.29965360
183neural tube development (GO:0021915)2.29269155
184outflow tract septum morphogenesis (GO:0003148)2.28284930
185regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.26204804
186dopaminergic neuron differentiation (GO:0071542)2.24803000
187regulation of axon extension involved in axon guidance (GO:0048841)2.24372564
188embryonic retina morphogenesis in camera-type eye (GO:0060059)2.24359317
189cytoskeletal anchoring at plasma membrane (GO:0007016)2.22894400
190lateral ventricle development (GO:0021670)2.22582533
191appendage development (GO:0048736)2.22435658
192limb development (GO:0060173)2.22435658
193glandular epithelial cell differentiation (GO:0002067)2.22154775
194microtubule depolymerization (GO:0007019)2.21784117
195establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.20696895
196pre-miRNA processing (GO:0031054)2.19671168
197gonadal mesoderm development (GO:0007506)10.1170848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.16801710
2SCL_19346495_ChIP-Seq_HPC-7_Human5.53667307
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.62166139
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.59441799
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.37423587
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.20328561
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88054729
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.87769647
9DROSHA_22980978_ChIP-Seq_HELA_Human2.86718466
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.80948686
11* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.77976360
12RUNX_20019798_ChIP-Seq_JUKART_Human2.77399680
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.60285216
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59655179
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56178630
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55157401
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54227489
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.51155833
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.47079517
20MYC_22102868_ChIP-Seq_BL_Human2.45959040
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44384667
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.39188356
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34711228
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31165776
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24357965
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.23602988
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.22004934
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19261635
29TCF7_22412390_ChIP-Seq_EML_Mouse2.14883556
30MAF_26560356_Chip-Seq_TH1_Human2.14660314
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.09820916
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08664031
33MYB_26560356_Chip-Seq_TH2_Human2.07011763
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06241331
35RNF2_27304074_Chip-Seq_ESCs_Mouse2.05626423
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.05259107
37RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04228616
38EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04228616
39EED_16625203_ChIP-ChIP_MESCs_Mouse2.03277781
40VDR_24763502_ChIP-Seq_THP-1_Human2.02643903
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95260008
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94262285
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93953070
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92717413
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91381374
46VDR_21846776_ChIP-Seq_THP-1_Human1.89914984
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89453042
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.85089760
49UTX_26944678_Chip-Seq_JUKART_Human1.82067132
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81118208
51MYB_26560356_Chip-Seq_TH1_Human1.78789214
52ZNF263_19887448_ChIP-Seq_K562_Human1.78739180
53* RUNX1_22412390_ChIP-Seq_EML_Mouse1.78234729
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75369400
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70522319
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70518579
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.68233177
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.68069300
59* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66217214
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65953455
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65504290
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65490901
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63811829
64KDM2B_26808549_Chip-Seq_K562_Human1.63207325
65* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61367612
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58156098
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57100499
68* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56981969
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55706470
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55122254
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53911176
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.53547321
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52429350
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52099766
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51519579
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50944553
77* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50783361
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50661206
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50476463
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.49058545
81* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46827753
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46763533
83* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.46166132
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45940401
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45136193
86* AHR_22903824_ChIP-Seq_MCF-7_Human1.42907405
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.42336098
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42295652
89CTCF_27219007_Chip-Seq_Bcells_Human1.41981050
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40208772
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39674697
92SPI1_23547873_ChIP-Seq_NB4_Human1.39332828
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37813735
94LXR_22292898_ChIP-Seq_THP-1_Human1.37764200
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36924743
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36901914
97RACK7_27058665_Chip-Seq_MCF-7_Human1.36784988
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36729352
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.36027685
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35158939
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34586861
102CREB1_26743006_Chip-Seq_LNCaP_Human1.33782674
103* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33495192
104NCOR1_26117541_ChIP-Seq_K562_Human1.32877690
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.32660556
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30932232
107SMC4_20622854_ChIP-Seq_HELA_Human1.29932064
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29672315
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29672315
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28505774
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28078449
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27932818
113* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27358831
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25822865
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23087786
116SOX2_20726797_ChIP-Seq_SW620_Human1.22601119
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21594147
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21193951
119KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20488808
120GATA3_27048872_Chip-Seq_THYMUS_Human1.19862731
121TP63_22573176_ChIP-Seq_HFKS_Human1.19744667
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19555681
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19227212
124* KLF5_25053715_ChIP-Seq_YYC3_Human1.19147183
125ESR1_20079471_ChIP-ChIP_T-47D_Human1.18745535
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.18115168
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17826841
128SMAD_19615063_ChIP-ChIP_OVARY_Human1.16684764
129CDX2_20551321_ChIP-Seq_CACO-2_Human1.15757311
130CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15467325
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14159727
132* ARNT_22903824_ChIP-Seq_MCF-7_Human1.13834433
133TRIM28_21343339_ChIP-Seq_HEK293_Human1.13796039
134* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13751972
135SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10688190
136MAF_26560356_Chip-Seq_TH2_Human1.10052537
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08505308
138* REST_21632747_ChIP-Seq_MESCs_Mouse1.07675743
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07368525
140PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05150853
141FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04996067
142GATA1_19941826_ChIP-Seq_K562_Human1.04693749
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04591778
144* ISL1_27105846_Chip-Seq_CPCs_Mouse1.04140422
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03711644
146* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01519845
147BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01218686
148* RUNX1_27514584_Chip-Seq_MCF-7_Human1.00931516
149KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00877411
150AR_19668381_ChIP-Seq_PC3_Human1.00735652
151CLOCK_20551151_ChIP-Seq_293T_Human1.00690389
152RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00143825
153THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00032569
154P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97161358
155HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97090350
156* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96669329
157NOTCH1_21737748_ChIP-Seq_TLL_Human0.96429822
158STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96057286
159EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95542884
160GATA1_22025678_ChIP-Seq_K562_Human0.95071493
161* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94996925
162CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93794654
163P68_20966046_ChIP-Seq_HELA_Human0.93741027
164FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92190694
165TET1_21490601_ChIP-Seq_MESCs_Mouse0.91992811
166* GATA2_19941826_ChIP-Seq_K562_Human0.90506757
167* PIAS1_25552417_ChIP-Seq_VCAP_Human0.90414656
168* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90191141
169* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90071889
170TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90063742
171TP53_23651856_ChIP-Seq_MEFs_Mouse0.89392789
172MYC_27129775_Chip-Seq_CORNEA_Mouse0.89288109
173YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88896251
174TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88844743
175TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88130229
176BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87717238
177KDM2B_26808549_Chip-Seq_DND41_Human0.86973518
178GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86721297
179* SMAD3_21741376_ChIP-Seq_HESCs_Human0.83826345
180* RARB_27405468_Chip-Seq_BRAIN_Mouse0.82606669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium3.96056773
2MP0002653_abnormal_ependyma_morphology3.52268538
3MP0000685_abnormal_immune_system2.93145890
4MP0005499_abnormal_olfactory_system2.74069001
5MP0005394_taste/olfaction_phenotype2.74069001
6MP0010030_abnormal_orbit_morphology2.71241369
7MP0003763_abnormal_thymus_physiology2.53979882
8MP0003787_abnormal_imprinting2.39429386
9MP0004043_abnormal_pH_regulation2.36045331
10MP0002396_abnormal_hematopoietic_system2.34451435
11MP0002638_abnormal_pupillary_reflex2.32571699
12MP0002254_reproductive_system_inflammat2.26150489
13MP0002822_catalepsy2.25987273
14MP0009780_abnormal_chondrocyte_physiolo2.11219777
15MP0002132_abnormal_respiratory_system2.09091931
16MP0001849_ear_inflammation2.07570826
17MP0004808_abnormal_hematopoietic_stem2.02458479
18MP0003724_increased_susceptibility_to1.98254045
19MP0001873_stomach_inflammation1.93858456
20MP0009785_altered_susceptibility_to1.92789888
21MP0001835_abnormal_antigen_presentation1.92535269
22MP0000566_synostosis1.90256760
23MP0000579_abnormal_nail_morphology1.86417232
24MP0010386_abnormal_urinary_bladder1.82112753
25MP0003705_abnormal_hypodermis_morpholog1.80118884
26MP0005409_darkened_coat_color1.79683135
27MP0005671_abnormal_response_to1.78789831
28MP0001348_abnormal_lacrimal_gland1.77900332
29MP0002877_abnormal_melanocyte_morpholog1.77171857
30MP0002233_abnormal_nose_morphology1.76683245
31MP0000465_gastrointestinal_hemorrhage1.75008619
32MP0009053_abnormal_anal_canal1.69558775
33MP0005503_abnormal_tendon_morphology1.68645795
34MP0002796_impaired_skin_barrier1.67233998
35MP0001984_abnormal_olfaction1.67029662
36MP0001545_abnormal_hematopoietic_system1.65471574
37MP0005397_hematopoietic_system_phenotyp1.65471574
38MP0002909_abnormal_adrenal_gland1.63813040
39MP0010155_abnormal_intestine_physiology1.63673265
40MP0003866_abnormal_defecation1.62204865
41MP0004858_abnormal_nervous_system1.61978852
42MP0005076_abnormal_cell_differentiation1.59073228
43MP0006292_abnormal_olfactory_placode1.56655877
44MP0003941_abnormal_skin_development1.56324768
45MP0010234_abnormal_vibrissa_follicle1.52949479
46MP0001851_eye_inflammation1.52490858
47MP0002933_joint_inflammation1.50295200
48MP0009278_abnormal_bone_marrow1.49201049
49MP0001188_hyperpigmentation1.49062336
50MP0002398_abnormal_bone_marrow1.43733805
51MP0002938_white_spotting1.43209916
52MP0001790_abnormal_immune_system1.42683467
53MP0005387_immune_system_phenotype1.42683467
54MP0000383_abnormal_hair_follicle1.42144047
55MP0005025_abnormal_response_to1.41215802
56MP0002249_abnormal_larynx_morphology1.41137674
57MP0008877_abnormal_DNA_methylation1.41049292
58MP0008007_abnormal_cellular_replicative1.40835571
59MP0002405_respiratory_system_inflammati1.39398295
60MP0008058_abnormal_DNA_repair1.38323997
61MP0010678_abnormal_skin_adnexa1.37788328
62MP0004133_heterotaxia1.36796695
63MP0000778_abnormal_nervous_system1.36489127
64MP0002184_abnormal_innervation1.35838985
65MP0002734_abnormal_mechanical_nocicepti1.35676175
66MP0003861_abnormal_nervous_system1.34235946
67MP0001958_emphysema1.33820737
68MP0001270_distended_abdomen1.33216923
69MP0000703_abnormal_thymus_morphology1.32391909
70MP0002735_abnormal_chemical_nociception1.30831773
71MP0002420_abnormal_adaptive_immunity1.30701259
72MP0001346_abnormal_lacrimal_gland1.30511671
73MP0002116_abnormal_craniofacial_bone1.30415557
74MP0005670_abnormal_white_adipose1.28628382
75MP0005464_abnormal_platelet_physiology1.28408873
76MP0000716_abnormal_immune_system1.27819137
77MP0010352_gastrointestinal_tract_polyps1.27698887
78MP0000490_abnormal_crypts_of1.26973883
79MP0008004_abnormal_stomach_pH1.26352596
80MP0002098_abnormal_vibrissa_morphology1.26105667
81MP0001819_abnormal_immune_cell1.25452556
82MP0001800_abnormal_humoral_immune1.25216669
83MP0003890_abnormal_embryonic-extraembry1.25049987
84MP0002108_abnormal_muscle_morphology1.24557202
85MP0002452_abnormal_antigen_presenting1.23163366
86MP0000678_abnormal_parathyroid_gland1.22745266
87MP0002168_other_aberrant_phenotype1.22388070
88MP0005646_abnormal_pituitary_gland1.22122257
89MP0001853_heart_inflammation1.20692338
90MP0005623_abnormal_meninges_morphology1.20611186
91MP0001299_abnormal_eye_distance/1.20064191
92MP0006054_spinal_hemorrhage1.18722857
93MP0003937_abnormal_limbs/digits/tail_de1.18035739
94MP0004885_abnormal_endolymph1.17756147
95MP0003453_abnormal_keratinocyte_physiol1.17552920
96MP0002723_abnormal_immune_serum1.16983381
97MP0000955_abnormal_spinal_cord1.16314795
98MP0000733_abnormal_muscle_development1.15865810
99MP0010368_abnormal_lymphatic_system1.15595053
100MP0003942_abnormal_urinary_system1.15382273
101MP0000470_abnormal_stomach_morphology1.15223343
102MP0000689_abnormal_spleen_morphology1.14895414
103MP0003755_abnormal_palate_morphology1.13969199
104MP0003045_fibrosis1.13283471
105MP0000534_abnormal_ureter_morphology1.12978893
106MP0006276_abnormal_autonomic_nervous1.12260288
107MP0005508_abnormal_skeleton_morphology1.12094713
108MP0002722_abnormal_immune_system1.11799949
109MP0002160_abnormal_reproductive_system1.11224886
110MP0003878_abnormal_ear_physiology1.09661323
111MP0005377_hearing/vestibular/ear_phenot1.09661323
112MP0001293_anophthalmia1.09394882
113MP0000762_abnormal_tongue_morphology1.08492611
114MP0000537_abnormal_urethra_morphology1.08380449
115MP0003935_abnormal_craniofacial_develop1.07350529
116MP0002234_abnormal_pharynx_morphology1.06823841
117MP0003943_abnormal_hepatobiliary_system1.06278494
118MP0002429_abnormal_blood_cell1.05935635
119MP0002697_abnormal_eye_size1.05866151
120MP0004264_abnormal_extraembryonic_tissu1.04139445
121MP0000049_abnormal_middle_ear1.03076822
122MP0005257_abnormal_intraocular_pressure1.02149559
123MP0005248_abnormal_Harderian_gland1.02002742
124MP0002060_abnormal_skin_morphology1.01694739
125MP0000681_abnormal_thyroid_gland0.99816483
126MP0002932_abnormal_joint_morphology0.99021453
127MP0000631_abnormal_neuroendocrine_gland0.98855549
128MP0000432_abnormal_head_morphology0.98834033
129MP0000026_abnormal_inner_ear0.98738581
130MP0000613_abnormal_salivary_gland0.97976853
131MP0003879_abnormal_hair_cell0.97083670
132MP0003938_abnormal_ear_development0.96354099
133MP0003115_abnormal_respiratory_system0.95577516
134MP0005000_abnormal_immune_tolerance0.95302224
135MP0002896_abnormal_bone_mineralization0.94707869
136MP0009250_abnormal_appendicular_skeleto0.91812411
137MP0005501_abnormal_skin_physiology0.91654831
138MP0002882_abnormal_neuron_morphology0.91395424
139MP0009379_abnormal_foot_pigmentation0.90555558
140MP0005075_abnormal_melanosome_morpholog0.90195947
141MP0004134_abnormal_chest_morphology0.89022250
142MP0004859_abnormal_synaptic_plasticity0.88501665
143MP0002152_abnormal_brain_morphology0.88149329
144MP0005174_abnormal_tail_pigmentation0.87320922
145MP0005220_abnormal_exocrine_pancreas0.86895226
146MP0002277_abnormal_respiratory_mucosa0.86624976
147MP0001664_abnormal_digestion0.86506941
148MP0005023_abnormal_wound_healing0.86340313
149MP0002095_abnormal_skin_pigmentation0.86168680
150MP0003300_gastrointestinal_ulcer0.85604870
151MP0002089_abnormal_postnatal_growth/wei0.84955577
152MP0001879_abnormal_lymphatic_vessel0.84599969
153MP0006082_CNS_inflammation0.83951920
154MP0005275_abnormal_skin_tensile0.82820481
155MP0004811_abnormal_neuron_physiology0.82496096
156MP0002557_abnormal_social/conspecific_i0.82419284
157MP0000462_abnormal_digestive_system0.82044044
158MP0000538_abnormal_urinary_bladder0.81111740
159MP0002114_abnormal_axial_skeleton0.80715313
160MP0002752_abnormal_somatic_nervous0.80509581
161MP0002166_altered_tumor_susceptibility0.79639409
162MP0005423_abnormal_somatic_nervous0.79026217
163MP0000477_abnormal_intestine_morphology0.78744683
164MP0005197_abnormal_uvea_morphology0.77594208
165MP0000467_abnormal_esophagus_morphology0.77264346
166MP0001542_abnormal_bone_strength0.77017437
167MP0002419_abnormal_innate_immunity0.76199056
168MP0002111_abnormal_tail_morphology0.76094119
169MP0002085_abnormal_embryonic_tissue0.75883003
170MP0004147_increased_porphyrin_level0.75666444
171MP0002177_abnormal_outer_ear0.74939181
172MP0001216_abnormal_epidermal_layer0.73921660
173MP0000647_abnormal_sebaceous_gland0.73858479
174MP0000377_abnormal_hair_follicle0.73550506

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.91970247
2Abnormal respiratory motile cilium physiology (HP:0012261)6.99843368
3Abnormal ciliary motility (HP:0012262)6.77552596
4Abnormal respiratory epithelium morphology (HP:0012253)6.62847828
5Abnormal respiratory motile cilium morphology (HP:0005938)6.62847828
6Rhinitis (HP:0012384)6.19247213
7Chronic bronchitis (HP:0004469)6.11004916
8Dynein arm defect of respiratory motile cilia (HP:0012255)5.98685499
9Absent/shortened dynein arms (HP:0200106)5.98685499
10Bronchiectasis (HP:0002110)4.61119962
11Onycholysis (HP:0001806)4.60359704
12Thrombocytosis (HP:0001894)4.17008478
13Chronic otitis media (HP:0000389)4.06043718
14Aplastic anemia (HP:0001915)3.94381878
15Interstitial pulmonary disease (HP:0006530)3.92026891
16Hypothermia (HP:0002045)3.63963685
17Hyperactive renin-angiotensin system (HP:0000841)3.51944946
18Milia (HP:0001056)3.51208866
19Pili torti (HP:0003777)3.40929443
20IgM deficiency (HP:0002850)3.24211301
21Prolonged bleeding time (HP:0003010)3.22903828
22Elevated erythrocyte sedimentation rate (HP:0003565)3.21458463
23Type 2 muscle fiber atrophy (HP:0003554)3.16339323
24Lip pit (HP:0100267)3.14773028
25Abnormality of the intervertebral disk (HP:0005108)3.14278704
26Muscle fiber atrophy (HP:0100295)3.14147164
27Spontaneous hematomas (HP:0007420)3.10830261
28Myositis (HP:0100614)3.06371660
29Abnormality of the nasal mucosa (HP:0000433)2.92428747
30Infertility (HP:0000789)2.91236258
31Atrophic scars (HP:0001075)2.86500583
32Palpebral edema (HP:0100540)2.81705137
33Weak cry (HP:0001612)2.81071524
34Atelectasis (HP:0100750)2.80102014
35Recurrent bronchitis (HP:0002837)2.79619781
36Hypoplastic labia majora (HP:0000059)2.78762315
37Fragile nails (HP:0001808)2.76722167
38Obstructive sleep apnea (HP:0002870)2.74783436
39Male infertility (HP:0003251)2.66204728
40Syringomyelia (HP:0003396)2.64769857
41Spinal cord lesions (HP:0100561)2.64769857
42Abnormality of the distal phalanges of the toes (HP:0010182)2.62967267
43Recurrent otitis media (HP:0000403)2.61931734
44Hyperkalemia (HP:0002153)2.60058219
45Arterial tortuosity (HP:0005116)2.58962810
46Decreased circulating renin level (HP:0003351)2.58284943
47Abnormality of the labia majora (HP:0012881)2.48547374
48IgG deficiency (HP:0004315)2.47185258
49Esophageal atresia (HP:0002032)2.44050276
50Abnormality of permanent molar morphology (HP:0011071)2.37712450
51Abnormality of the dental root (HP:0006486)2.37712450
52Taurodontia (HP:0000679)2.37712450
53Nasal polyposis (HP:0100582)2.35565074
54Abnormality of T cell physiology (HP:0011840)2.35271080
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.30792346
56Asplenia (HP:0001746)2.30592137
57Pelvic girdle muscle weakness (HP:0003749)2.29800421
58Abnormality of molar (HP:0011077)2.28849309
59Abnormality of molar morphology (HP:0011070)2.28849309
60Micronodular cirrhosis (HP:0001413)2.28673558
61Tubulointerstitial nephritis (HP:0001970)2.27969029
62Stomach cancer (HP:0012126)2.23652187
63Periorbital edema (HP:0100539)2.23195487
64Orchitis (HP:0100796)2.22779012
65Asymmetry of the thorax (HP:0001555)2.22478088
66Vascular tortuosity (HP:0004948)2.22305657
67Slow-growing hair (HP:0002217)2.21975704
68Abnormality of hair growth rate (HP:0011363)2.21975704
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.19924767
70Genetic anticipation (HP:0003743)2.19772420
71Nonprogressive disorder (HP:0003680)2.19683828
72Short nail (HP:0001799)2.19498158
73Occipital encephalocele (HP:0002085)2.18448902
74Chronic sinusitis (HP:0011109)2.16614092
75Bowing of the arm (HP:0006488)2.16038730
76Bowed forearm bones (HP:0003956)2.16038730
77Right ventricular cardiomyopathy (HP:0011663)2.13726282
78Bell-shaped thorax (HP:0001591)2.13508177
79Abnormality of the dental pulp (HP:0006479)2.11495379
80Acute myeloid leukemia (HP:0004808)2.10597002
81Labial hypoplasia (HP:0000066)2.09508807
82Facial edema (HP:0000282)2.08896933
83Bronchitis (HP:0012387)2.08841705
84Popliteal pterygium (HP:0009756)2.08633456
85Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07866971
86Abnormality of cells of the erythroid lineage (HP:0012130)2.07732974
87Chronic hepatic failure (HP:0100626)2.07148999
88Abnormal platelet function (HP:0011869)2.06881553
89Impaired platelet aggregation (HP:0003540)2.06881553
90Petechiae (HP:0000967)2.06208480
91Cystic liver disease (HP:0006706)2.05891227
92White forelock (HP:0002211)2.05081082
93Natal tooth (HP:0000695)2.02675359
94Growth hormone excess (HP:0000845)2.02310826
95Panhypogammaglobulinemia (HP:0003139)2.01284549
96Epistaxis (HP:0000421)1.97302606
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96055132
98Broad face (HP:0000283)1.95928135
99Alacrima (HP:0000522)1.95649220
100Renal salt wasting (HP:0000127)1.95509864
101Aplasia cutis congenita (HP:0001057)1.94969572
102Hypoplastic female external genitalia (HP:0012815)1.94585161
103Beaking of vertebral bodies (HP:0004568)1.94339537
104Patchy hypopigmentation of hair (HP:0011365)1.94329951
105Radial bowing (HP:0002986)1.93653634
106Abnormality of the aortic arch (HP:0012303)1.93500314
107Abnormality of the hip-girdle musculature (HP:0001445)1.91900625
108Abnormality of the musculature of the pelvis (HP:0001469)1.91900625
109Abnormality of renin-angiotensin system (HP:0000847)1.91739565
110Wormian bones (HP:0002645)1.91389210
111Cutaneous finger syndactyly (HP:0010554)1.90903554
112Increased IgM level (HP:0003496)1.90631609
113Abnormality of chloride homeostasis (HP:0011422)1.90619283
114Abnormality of the gastric mucosa (HP:0004295)1.89983738
115Abnormal number of erythroid precursors (HP:0012131)1.89128420
116Abnormal delayed hypersensitivity skin test (HP:0002963)1.89118724
117Abnormality of T cells (HP:0002843)1.89058064
118Oligodontia (HP:0000677)1.89022721
119Spondylolisthesis (HP:0003302)1.88788919
120Flat acetabular roof (HP:0003180)1.87136989
121Aortic aneurysm (HP:0004942)1.86008732
122Aplasia of the phalanges of the hand (HP:0009802)1.84836989
123Aplasia involving bones of the extremities (HP:0009825)1.84836989
124Aplasia involving bones of the upper limbs (HP:0009823)1.84836989
125Germ cell neoplasia (HP:0100728)1.83569734
126Hyperacusis (HP:0010780)1.83149253
127IgA deficiency (HP:0002720)1.82136920
128Osteolytic defects of the hand bones (HP:0009699)1.76665242
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.76665242
130Eczematoid dermatitis (HP:0000976)1.76500307
131Recurrent sinusitis (HP:0011108)1.76342877
132Vertebral arch anomaly (HP:0008438)1.75956489
133Increased IgE level (HP:0003212)1.75379227
134Abnormal hair laboratory examination (HP:0003328)1.75063825
135Skin pits (HP:0100276)1.73891589
136Cutaneous syndactyly (HP:0012725)1.70697834
137Hyperaldosteronism (HP:0000859)1.69246198
138Hydroureter (HP:0000072)1.69233273
139Ureteral obstruction (HP:0006000)1.68925961
140Flat cornea (HP:0007720)1.67259267
141Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.67104946
142Abnormality of the parietal bone (HP:0002696)1.66933167
143Advanced eruption of teeth (HP:0006288)1.66606339
144Nasolacrimal duct obstruction (HP:0000579)1.66315896
145Vasculitis (HP:0002633)1.66043402
146Myokymia (HP:0002411)1.64926417
147Gastrointestinal stroma tumor (HP:0100723)1.64785513
148Abnormality of the phalanges of the hallux (HP:0010057)1.64580022
149Long eyelashes (HP:0000527)1.64303055
150Stomatitis (HP:0010280)1.64221561
151Persistence of primary teeth (HP:0006335)1.63889594
152Hypoproteinemia (HP:0003075)1.63750931
153Retrobulbar optic neuritis (HP:0100654)1.63457785
154Optic neuritis (HP:0100653)1.63457785
155Woolly hair (HP:0002224)1.62227962
156Neonatal short-limb short stature (HP:0008921)1.61810772
157Hepatitis (HP:0012115)1.61689121
158Stridor (HP:0010307)1.61595901
159Abnormality of the salivary glands (HP:0010286)1.61246679
160Recurrent fungal infections (HP:0002841)1.61209430
161Elfin facies (HP:0004428)1.60953261
162Portal hypertension (HP:0001409)1.60665046
163Abnormality of the distal phalanx of the thumb (HP:0009617)1.60589583
164Bifid scrotum (HP:0000048)1.58928402
165Nephronophthisis (HP:0000090)1.58821958
166Abnormality of the fingertips (HP:0001211)1.56297455
167Self-mutilation (HP:0000742)1.54591300
168Decreased lacrimation (HP:0000633)1.50417740
169Down-sloping shoulders (HP:0200021)1.50051544
170Partial duplication of thumb phalanx (HP:0009944)1.49309571
171Anomalous pulmonary venous return (HP:0010772)1.47959788
172Tubular atrophy (HP:0000092)1.46408092
173Hypoplasia of dental enamel (HP:0006297)1.45975605
174Abnormality of the columella (HP:0009929)1.45458663
175Laryngomalacia (HP:0001601)1.45212448
176Absent eyelashes (HP:0000561)1.44880332
177Abdominal situs inversus (HP:0003363)1.44543496
178Abnormality of abdominal situs (HP:0011620)1.44543496
179Renovascular hypertension (HP:0100817)1.43169837
180Spinal cord compression (HP:0002176)1.43004965
181Hypoventilation (HP:0002791)1.42689327
182Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.42223165
183Abnormality of incisor morphology (HP:0011063)1.41455984
184Spina bifida occulta (HP:0003298)1.41049314
185True hermaphroditism (HP:0010459)1.40695780
186Abnormality of the renal medulla (HP:0100957)1.39638623
187Dysmetric saccades (HP:0000641)1.39609641
188Partial duplication of the phalanx of hand (HP:0009999)1.39413725
189Sleep apnea (HP:0010535)1.39407187
190Abnormality of the lacrimal duct (HP:0011481)1.39157351
191Urethral obstruction (HP:0000796)1.39012477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB35.00360813
2CDK193.35806655
3PLK43.17361837
4TGFBR23.05512976
5CDK122.84270726
6TGFBR12.67074186
7BMPR22.62952589
8ICK2.53208655
9TIE12.50974326
10CAMK1G2.47849714
11NME12.38167875
12CAMK1D2.23384406
13TXK2.19276029
14ZAP702.12954318
15MAP3K122.10003376
16KIT2.06764508
17RPS6KB22.04984891
18SMG12.00479483
19MAP3K31.97462622
20BTK1.91501567
21MAPK151.91214154
22SIK21.90271635
23MAP4K11.89572644
24EPHB11.84935355
25EPHA21.80338107
26BLK1.79525134
27MAPKAPK31.72804925
28RIPK11.68682393
29MAP2K31.68033467
30CASK1.65255473
31NLK1.63401406
32IKBKE1.55073749
33LRRK21.53256199
34TEC1.52687981
35NUAK11.42989766
36JAK31.42971885
37SIK11.41525551
38MTOR1.39864148
39EPHA31.36700002
40MAP3K101.36289141
41STK161.33744746
42STK241.32694538
43MATK1.32408745
44PRKD31.28515567
45MAPKAPK51.27752076
46RPS6KA21.27691718
47EEF2K1.26635560
48VRK11.26583226
49MAP2K21.25852919
50NME21.25590754
51MAP3K91.23558170
52CAMKK11.20584354
53PNCK1.20519593
54IRAK41.15329205
55INSRR1.14643838
56STK101.14209535
57MST41.14080600
58NTRK11.13280117
59MAP3K21.12732013
60TBK11.10747566
61PTK21.10443188
62STK38L1.08437667
63TNIK1.07456919
64BCR1.04988318
65NTRK31.02950140
66MYLK1.00936253
67LATS21.00290897
68FGFR20.97560334
69TESK10.97411690
70PRKCH0.97021982
71PAK40.96795783
72PTK60.96338217
73CDK80.96224149
74TRIB30.96194478
75MINK10.95556324
76PDGFRA0.95061447
77MST1R0.94799697
78MKNK10.94147017
79CSF1R0.90301735
80ILK0.89594905
81HIPK20.87913003
82NEK90.85782049
83BRD40.84317359
84PIM20.83189623
85PKN20.82364060
86IRAK10.82082687
87BMPR1B0.81636692
88IKBKB0.81010796
89DYRK30.79624167
90PIK3CA0.77005199
91TSSK60.75971287
92OXSR10.75794991
93CDC42BPA0.75710411
94SGK4940.75553795
95SGK2230.75553795
96STK380.73694676
97NEK60.73047656
98LATS10.71980542
99CDK70.69279317
100PRKCI0.68880079
101LCK0.67358055
102MAP3K60.66884387
103ITK0.66485587
104TYK20.66114497
105NEK20.66009676
106TNK20.65487488
107AURKA0.65004217
108MELK0.64959010
109FGFR40.64081383
110NTRK20.63909403
111TYRO30.63365271
112MET0.61626082
113CHUK0.60146986
114CDK60.60113351
115PRPF4B0.58304910
116PRKAA10.54815644
117STK110.54798737
118FLT30.54286277
119CSNK1E0.53547898
120PASK0.53244822
121CAMK40.53021409
122TTK0.52833122
123MUSK0.52291328
124TRPM70.52030377
125CDK30.51706450
126CDK90.51444290
127PRKD20.50538869
128HCK0.50362193
129STK390.50272669
130RPS6KA40.50163143
131CSNK1G30.49933034
132PDGFRB0.49835876
133GSK3B0.49155600
134RPS6KA50.49099959
135MAPKAPK20.48693921
136MARK20.48219999
137RPS6KA60.47694008
138ERBB20.47353692
139RPS6KC10.45730974
140RPS6KL10.45730974
141FGFR30.45014996
142SGK20.44964081
143PRKG20.44666707
144PRKCZ0.44424076
145LMTK20.43592081
146SYK0.43381758
147RET0.42942096
148DDR20.42655175
149SGK30.42613391
150MAPK80.42329228
151MAP3K70.41648016
152CDK20.40998105
153CSNK1A1L0.40256812
154DMPK0.39849748
155AKT20.39654699
156SIK30.39388667
157SGK10.39129178
158CSNK1G10.39086056
159KDR0.38533734
160PAK20.37834160
161RPS6KB10.37631684
162MAPK30.37593933
163ARAF0.36865264
164MAPK140.36326999
165ACVR1B0.36103599
166EPHB20.35222908
167MAP3K140.34354803
168FER0.32925762
169MAPK40.32269127
170MAP2K60.30245985
171ERN10.29922609

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.96715064
2Primary immunodeficiency_Homo sapiens_hsa053402.89507694
3Phenylalanine metabolism_Homo sapiens_hsa003602.39867800
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.37916998
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.08347897
6Caffeine metabolism_Homo sapiens_hsa002322.05921302
7Histidine metabolism_Homo sapiens_hsa003402.02384718
8Non-homologous end-joining_Homo sapiens_hsa034502.02022560
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01891027
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.97846925
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.91437221
12Acute myeloid leukemia_Homo sapiens_hsa052211.90950384
13Base excision repair_Homo sapiens_hsa034101.83350626
14Axon guidance_Homo sapiens_hsa043601.76772667
15B cell receptor signaling pathway_Homo sapiens_hsa046621.68129453
16Hedgehog signaling pathway_Homo sapiens_hsa043401.66575815
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65594330
18Toxoplasmosis_Homo sapiens_hsa051451.63207412
19Chronic myeloid leukemia_Homo sapiens_hsa052201.55847367
20Tyrosine metabolism_Homo sapiens_hsa003501.55638337
21Notch signaling pathway_Homo sapiens_hsa043301.55567196
22T cell receptor signaling pathway_Homo sapiens_hsa046601.53395047
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53302373
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.52134957
25Measles_Homo sapiens_hsa051621.51750540
26Leishmaniasis_Homo sapiens_hsa051401.49681383
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49159383
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.48303931
29Nicotine addiction_Homo sapiens_hsa050331.47793196
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47189016
31Hematopoietic cell lineage_Homo sapiens_hsa046401.46593179
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.44700248
33Cholinergic synapse_Homo sapiens_hsa047251.41534050
34Hepatitis C_Homo sapiens_hsa051601.39936552
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39416008
36Pancreatic cancer_Homo sapiens_hsa052121.38809327
37Glioma_Homo sapiens_hsa052141.36437811
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35774041
39Melanogenesis_Homo sapiens_hsa049161.35344116
40DNA replication_Homo sapiens_hsa030301.34930171
41MicroRNAs in cancer_Homo sapiens_hsa052061.31972904
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30982645
43Herpes simplex infection_Homo sapiens_hsa051681.29902762
44Glutamatergic synapse_Homo sapiens_hsa047241.29621072
45Lysine degradation_Homo sapiens_hsa003101.28138949
46Thyroid cancer_Homo sapiens_hsa052161.27934579
47TNF signaling pathway_Homo sapiens_hsa046681.27383967
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26189173
49beta-Alanine metabolism_Homo sapiens_hsa004101.25007426
50Small cell lung cancer_Homo sapiens_hsa052221.24196319
51Cocaine addiction_Homo sapiens_hsa050301.23780809
52ErbB signaling pathway_Homo sapiens_hsa040121.23207306
53Choline metabolism in cancer_Homo sapiens_hsa052311.23133060
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22241312
55Autoimmune thyroid disease_Homo sapiens_hsa053201.22187956
56Colorectal cancer_Homo sapiens_hsa052101.21421470
57Platelet activation_Homo sapiens_hsa046111.21241266
58Allograft rejection_Homo sapiens_hsa053301.20757277
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20649536
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20038578
61ECM-receptor interaction_Homo sapiens_hsa045121.19748309
62Estrogen signaling pathway_Homo sapiens_hsa049151.19379428
63Prolactin signaling pathway_Homo sapiens_hsa049171.19378801
64Chemical carcinogenesis_Homo sapiens_hsa052041.18452148
65Hepatitis B_Homo sapiens_hsa051611.11590771
66Osteoclast differentiation_Homo sapiens_hsa043801.10300915
67Cyanoamino acid metabolism_Homo sapiens_hsa004601.09735804
68Renal cell carcinoma_Homo sapiens_hsa052111.09478339
69Antigen processing and presentation_Homo sapiens_hsa046121.09272924
70mTOR signaling pathway_Homo sapiens_hsa041501.08632259
71Apoptosis_Homo sapiens_hsa042101.08238661
72Adherens junction_Homo sapiens_hsa045201.07380585
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06111932
74Sphingolipid metabolism_Homo sapiens_hsa006001.04939825
75Shigellosis_Homo sapiens_hsa051311.04818315
76Asthma_Homo sapiens_hsa053101.03473509
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02902435
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02105579
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01862766
80Vibrio cholerae infection_Homo sapiens_hsa051101.01368082
81Dilated cardiomyopathy_Homo sapiens_hsa054141.00830749
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99236596
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.99015625
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98855476
85Malaria_Homo sapiens_hsa051440.98201444
86Melanoma_Homo sapiens_hsa052180.97751041
87HTLV-I infection_Homo sapiens_hsa051660.94619136
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93871620
89Taste transduction_Homo sapiens_hsa047420.93329648
90Gap junction_Homo sapiens_hsa045400.92990550
91Pathways in cancer_Homo sapiens_hsa052000.92210406
92Viral myocarditis_Homo sapiens_hsa054160.89914961
93RNA polymerase_Homo sapiens_hsa030200.88717632
94Influenza A_Homo sapiens_hsa051640.85418414
95Glutathione metabolism_Homo sapiens_hsa004800.84419119
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83515063
97Pertussis_Homo sapiens_hsa051330.83133645
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83062947
99Dopaminergic synapse_Homo sapiens_hsa047280.82576999
100AMPK signaling pathway_Homo sapiens_hsa041520.82111517
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81852714
102Circadian rhythm_Homo sapiens_hsa047100.81217807
103Focal adhesion_Homo sapiens_hsa045100.80777157
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79753068
105cAMP signaling pathway_Homo sapiens_hsa040240.79152221
106Synaptic vesicle cycle_Homo sapiens_hsa047210.78704463
107Spliceosome_Homo sapiens_hsa030400.78357626
108Endometrial cancer_Homo sapiens_hsa052130.77853813
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77556754
110FoxO signaling pathway_Homo sapiens_hsa040680.77406277
111Gastric acid secretion_Homo sapiens_hsa049710.77093282
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74910309
113Oxytocin signaling pathway_Homo sapiens_hsa049210.74542049
114Non-small cell lung cancer_Homo sapiens_hsa052230.74531952
115Rap1 signaling pathway_Homo sapiens_hsa040150.74303858
116Huntingtons disease_Homo sapiens_hsa050160.73010111
117Circadian entrainment_Homo sapiens_hsa047130.72607953
118Serotonergic synapse_Homo sapiens_hsa047260.72126333
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71940362
120Chemokine signaling pathway_Homo sapiens_hsa040620.71306813
121Arachidonic acid metabolism_Homo sapiens_hsa005900.70823890
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67513940
123Amoebiasis_Homo sapiens_hsa051460.67339677
124GABAergic synapse_Homo sapiens_hsa047270.67008381
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66636885
126Inositol phosphate metabolism_Homo sapiens_hsa005620.66095802
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64891599
128Proteoglycans in cancer_Homo sapiens_hsa052050.64729177
129Tight junction_Homo sapiens_hsa045300.64261969
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63589759
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.63422081
132Insulin signaling pathway_Homo sapiens_hsa049100.63395110
133Type II diabetes mellitus_Homo sapiens_hsa049300.62340260
134Salmonella infection_Homo sapiens_hsa051320.61453479
135Retinol metabolism_Homo sapiens_hsa008300.61225947
136Basal cell carcinoma_Homo sapiens_hsa052170.60593384
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60493826
138TGF-beta signaling pathway_Homo sapiens_hsa043500.60386063
139p53 signaling pathway_Homo sapiens_hsa041150.60360640
140Ras signaling pathway_Homo sapiens_hsa040140.60053996
141Phototransduction_Homo sapiens_hsa047440.57590580
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57083577
143GnRH signaling pathway_Homo sapiens_hsa049120.56283495
144Morphine addiction_Homo sapiens_hsa050320.56076916
145Salivary secretion_Homo sapiens_hsa049700.56030644
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55999417
147Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54364031
148Dorso-ventral axis formation_Homo sapiens_hsa043200.53875031
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.53173973
150Epstein-Barr virus infection_Homo sapiens_hsa051690.53102226
151Wnt signaling pathway_Homo sapiens_hsa043100.53097018
152Thyroid hormone synthesis_Homo sapiens_hsa049180.53078971
153Nucleotide excision repair_Homo sapiens_hsa034200.52517827
154Insulin secretion_Homo sapiens_hsa049110.52391301
155Pyrimidine metabolism_Homo sapiens_hsa002400.52212182
156Hippo signaling pathway_Homo sapiens_hsa043900.51945363
157Folate biosynthesis_Homo sapiens_hsa007900.51218407
158Bladder cancer_Homo sapiens_hsa052190.50306371
159Legionellosis_Homo sapiens_hsa051340.48383916
160N-Glycan biosynthesis_Homo sapiens_hsa005100.47250510
161Viral carcinogenesis_Homo sapiens_hsa052030.46988106
162Protein export_Homo sapiens_hsa030600.46742677
163VEGF signaling pathway_Homo sapiens_hsa043700.46549514
164Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45754425
165Prostate cancer_Homo sapiens_hsa052150.44131712
166Sulfur metabolism_Homo sapiens_hsa009200.44004685
167Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43603309

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