EXTL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.40823930
2hemidesmosome assembly (GO:0031581)4.38641302
3postsynaptic membrane organization (GO:0001941)4.28364867
4synaptic vesicle maturation (GO:0016188)4.15003450
5sodium ion export (GO:0071436)4.12693439
6planar cell polarity pathway involved in neural tube closure (GO:0090179)4.07853113
7locomotory exploration behavior (GO:0035641)3.96120345
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80423238
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.74945747
10cell communication by electrical coupling (GO:0010644)3.72074214
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.69136119
12presynaptic membrane assembly (GO:0097105)3.66663187
13regulation of gene silencing by RNA (GO:0060966)3.63211220
14regulation of posttranscriptional gene silencing (GO:0060147)3.63211220
15regulation of gene silencing by miRNA (GO:0060964)3.63211220
16layer formation in cerebral cortex (GO:0021819)3.61694755
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.61284774
18convergent extension (GO:0060026)3.48895699
19mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.43250588
20cellular potassium ion homeostasis (GO:0030007)3.34309856
21activation of protein kinase A activity (GO:0034199)3.32663142
22regulation of synapse structural plasticity (GO:0051823)3.27428168
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26500025
24camera-type eye morphogenesis (GO:0048593)3.24718692
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.23131166
26glutamate secretion (GO:0014047)3.17565572
27presynaptic membrane organization (GO:0097090)3.14815334
28proline transport (GO:0015824)3.10789220
29alanine transport (GO:0032328)3.08426030
30notochord development (GO:0030903)3.07536474
31plasma membrane repair (GO:0001778)3.05259251
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05100721
33G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.05075880
34establishment of nucleus localization (GO:0040023)3.04962428
35pyrimidine nucleobase catabolic process (GO:0006208)3.03037694
36neuronal stem cell maintenance (GO:0097150)3.02580921
37insulin-like growth factor receptor signaling pathway (GO:0048009)2.97962282
38vocalization behavior (GO:0071625)2.96999661
39neural tube development (GO:0021915)2.95382362
40stress fiber assembly (GO:0043149)2.94966621
41neuron recognition (GO:0008038)2.94338735
42Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.92919537
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91753363
44synaptic vesicle exocytosis (GO:0016079)2.91625362
45morphogenesis of an epithelial sheet (GO:0002011)2.86327296
46lung-associated mesenchyme development (GO:0060484)2.83045502
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82338853
48regulation of glutamate receptor signaling pathway (GO:1900449)2.81888983
49cell migration involved in sprouting angiogenesis (GO:0002042)2.81322175
50establishment of tissue polarity (GO:0007164)2.80879127
51establishment of planar polarity (GO:0001736)2.80879127
52amino acid import (GO:0043090)2.78275745
53regulation of establishment of planar polarity (GO:0090175)2.77886078
54regulation of ARF protein signal transduction (GO:0032012)2.77479191
55regulation of synaptic vesicle exocytosis (GO:2000300)2.77156433
56cell-substrate junction assembly (GO:0007044)2.76564594
57cell communication involved in cardiac conduction (GO:0086065)2.74227555
58cellular sodium ion homeostasis (GO:0006883)2.73898340
59establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.73477586
60neuromuscular process controlling balance (GO:0050885)2.67922613
61semaphorin-plexin signaling pathway (GO:0071526)2.67549599
62apical protein localization (GO:0045176)2.67433078
63potassium ion import (GO:0010107)2.66934836
64exploration behavior (GO:0035640)2.66153150
65regulation of cell fate specification (GO:0042659)2.63682334
66regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.63203038
67neuron cell-cell adhesion (GO:0007158)2.62906509
68dermatan sulfate biosynthetic process (GO:0030208)2.62551855
69regulation of axon extension involved in axon guidance (GO:0048841)2.62264609
70neuromuscular junction development (GO:0007528)2.62047412
71negative regulation of chondrocyte differentiation (GO:0032331)2.61264252
72myelination in peripheral nervous system (GO:0022011)2.60584067
73peripheral nervous system axon ensheathment (GO:0032292)2.60584067
74neuron projection extension (GO:1990138)2.60533026
75dendrite morphogenesis (GO:0048813)2.59629345
76positive regulation of glycogen biosynthetic process (GO:0045725)2.58653559
77establishment or maintenance of bipolar cell polarity (GO:0061245)2.58375256
78establishment or maintenance of apical/basal cell polarity (GO:0035088)2.58375256
79negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57659650
80lateral sprouting from an epithelium (GO:0060601)2.57520974
81regulation of NFAT protein import into nucleus (GO:0051532)2.57299963
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55830466
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55499020
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.54837225
85non-canonical Wnt signaling pathway (GO:0035567)2.54366514
86positive regulation of synapse maturation (GO:0090129)2.54013900
87positive regulation of fibroblast migration (GO:0010763)2.51705980
88apoptotic cell clearance (GO:0043277)2.50773032
89regulation of hippo signaling (GO:0035330)2.50367552
90neurotransmitter secretion (GO:0007269)2.49850420
91regulation of axon guidance (GO:1902667)2.49201735
92regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48671523
93ventricular trabecula myocardium morphogenesis (GO:0003222)2.47979286
94negative regulation of cell size (GO:0045792)2.47398934
95polarized epithelial cell differentiation (GO:0030859)2.46938032
96outer ear morphogenesis (GO:0042473)2.46308399
97calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46123129
98glycine transport (GO:0015816)2.45936861
99atrial septum morphogenesis (GO:0060413)2.45516536
100regulation of catenin import into nucleus (GO:0035412)2.44982504
101axon extension involved in axon guidance (GO:0048846)2.44618479
102neuron projection extension involved in neuron projection guidance (GO:1902284)2.44618479
103developmental cell growth (GO:0048588)2.44300828
104regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.44129970
105dendritic spine morphogenesis (GO:0060997)2.43842997
106regulation of ARF GTPase activity (GO:0032312)2.41690632
107ephrin receptor signaling pathway (GO:0048013)2.41428085
108protein localization to endosome (GO:0036010)2.40939013
109somatic stem cell division (GO:0048103)2.39810632
110dorsal/ventral axis specification (GO:0009950)2.39586605
111regulation of fatty acid beta-oxidation (GO:0031998)2.39313406
112regulation of synaptic vesicle transport (GO:1902803)2.37974553
113regulation of neuronal synaptic plasticity (GO:0048168)2.37888298
114negative regulation of fatty acid transport (GO:2000192)2.36863285
115mesenchymal to epithelial transition (GO:0060231)2.36299477
116positive regulation of synapse assembly (GO:0051965)2.35662120
117Notch signaling involved in heart development (GO:0061314)2.35423476
118adherens junction organization (GO:0034332)2.34966068
119membrane repolarization (GO:0086009)2.34898594
120innervation (GO:0060384)2.34342254
121negative regulation of potassium ion transmembrane transport (GO:1901380)2.33673197
122protein heterotrimerization (GO:0070208)2.33556459
123pre-miRNA processing (GO:0031054)2.33381886
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.33266311
125cardiac myofibril assembly (GO:0055003)2.33020024
126dermatan sulfate metabolic process (GO:0030205)2.32702932
127lymphangiogenesis (GO:0001946)2.32134455
128protein targeting to plasma membrane (GO:0072661)2.31799916
129L-amino acid import (GO:0043092)2.30368955
130negative regulation of catenin import into nucleus (GO:0035414)2.30036107
131generation of neurons (GO:0048699)2.30025094
132positive regulation of catenin import into nucleus (GO:0035413)2.29853873
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.29757557
134focal adhesion assembly (GO:0048041)2.29702796
135cell-substrate adherens junction assembly (GO:0007045)2.29702796
136negative regulation of sodium ion transport (GO:0010766)2.29578011
137regulation of long-term neuronal synaptic plasticity (GO:0048169)2.29399821
138regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.29042288
139mating behavior (GO:0007617)2.28878833
140negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.28381550
141cochlea morphogenesis (GO:0090103)2.28302111
142regulation of membrane repolarization (GO:0060306)2.28187785
143positive regulation of axon extension (GO:0045773)2.27871429
144nerve growth factor signaling pathway (GO:0038180)2.27676908
145cell migration in hindbrain (GO:0021535)2.27077108
146heterochromatin organization (GO:0070828)2.27072639
147cell surface receptor signaling pathway involved in heart development (GO:0061311)2.27005592
148gap junction assembly (GO:0016264)2.26848435
149positive regulation of SMAD protein import into nucleus (GO:0060391)2.26737924
150protein localization to synapse (GO:0035418)2.26447297
151positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.26043266
152heart valve formation (GO:0003188)2.25807654
153hippo signaling (GO:0035329)2.25717033
154negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.25601311
155spinal cord development (GO:0021510)2.25194341
156adherens junction assembly (GO:0034333)2.24373329
157establishment of apical/basal cell polarity (GO:0035089)2.24154330
158cerebellar Purkinje cell layer development (GO:0021680)2.23662736
159regulation of clathrin-mediated endocytosis (GO:2000369)2.23182858
160membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.22147824
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.20939136
162potassium ion homeostasis (GO:0055075)2.20174375
163axon extension (GO:0048675)2.19659597
164regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.17809012
165positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.17698170
166regulation of glycogen (starch) synthase activity (GO:2000465)2.16326233
167cerebellar Purkinje cell differentiation (GO:0021702)2.16222718
168positive regulation of glycogen metabolic process (GO:0070875)2.15970735
169positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.15483182
170membrane depolarization during action potential (GO:0086010)2.15287385
171G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.14808748
172regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.14329596
173positive regulation of potassium ion transmembrane transport (GO:1901381)2.12949999
174clathrin coat assembly (GO:0048268)2.10643311
175positive regulation of glucose import (GO:0046326)2.10161626
176regulation of tight junction assembly (GO:2000810)2.10138670
177regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.09825149
178neurotransmitter-gated ion channel clustering (GO:0072578)2.08855648
179gamma-aminobutyric acid transport (GO:0015812)2.06741014
180axonal fasciculation (GO:0007413)2.06445890
181positive regulation of fatty acid oxidation (GO:0046321)2.06428863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.11985444
2EZH2_22144423_ChIP-Seq_EOC_Human2.82587764
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56818131
4DROSHA_22980978_ChIP-Seq_HELA_Human2.27251655
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27136223
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27049690
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24470483
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22413636
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22413636
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11524805
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06342796
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03209696
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.01970694
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.99031722
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94545338
16KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92346718
17RARB_27405468_Chip-Seq_BRAIN_Mouse1.91179091
18* KDM2B_26808549_Chip-Seq_K562_Human1.91053269
19ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90901792
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.89394561
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86677130
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86657600
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84605922
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82318136
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80652403
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79839035
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.76675115
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76408825
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75602433
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72959975
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.69403712
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67280247
33* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65273053
34* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.62629370
35KDM2B_26808549_Chip-Seq_DND41_Human1.61351134
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.61217326
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.59738251
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.57451813
39CLOCK_20551151_ChIP-Seq_293T_Human1.57293366
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56199439
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56148254
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55512449
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54860767
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54278923
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.53658573
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.51775292
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50182548
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.49732523
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.49251719
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47789030
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47015668
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45227928
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45007502
54AR_21572438_ChIP-Seq_LNCaP_Human1.43852176
55LXR_22292898_ChIP-Seq_THP-1_Human1.43838208
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.40246515
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40146544
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.40133671
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.37955249
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35633428
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32629794
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32629794
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32629794
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30503985
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29578404
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25937594
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25825503
68GBX2_23144817_ChIP-Seq_PC3_Human1.24645118
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.24597708
70* REST_21632747_ChIP-Seq_MESCs_Mouse1.21672143
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21530761
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20917311
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20657061
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.20552986
75* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20116700
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20094696
77TP53_23651856_ChIP-Seq_MEFs_Mouse1.20094691
78PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.18506482
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16275162
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15390168
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.15194682
82AR_19668381_ChIP-Seq_PC3_Human1.14454936
83AHR_22903824_ChIP-Seq_MCF-7_Human1.12815512
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.12641661
85POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12234865
86* REST_18959480_ChIP-ChIP_MESCs_Mouse1.11997852
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11795840
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11023543
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10830892
90* TBX20_22080862_ChIP-Seq_HEART_Mouse1.10478942
91* TBX20_22328084_ChIP-Seq_HEART_Mouse1.10478942
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10150694
93TP53_22127205_ChIP-Seq_IMR90_Human1.09726698
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09465924
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.09073298
96* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08500526
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08472890
98ZNF263_19887448_ChIP-Seq_K562_Human1.07342543
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07239543
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07067443
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06533142
102CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05671303
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.05605040
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05348694
105CTCF_27219007_Chip-Seq_Bcells_Human1.05231178
106* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03719390
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03166924
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02984216
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.01789523
110CREB1_26743006_Chip-Seq_LNCaP_Human1.01777936
111ISL1_27105846_Chip-Seq_CPCs_Mouse1.01585103
112SOX2_21211035_ChIP-Seq_LN229_Gbm1.01227926
113RXR_22108803_ChIP-Seq_LS180_Human1.01027499
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.00484230
115RING1B_27294783_Chip-Seq_NPCs_Mouse0.99515710
116NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99390691
117CBX2_27304074_Chip-Seq_ESCs_Mouse0.99296329
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99075735
119* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98967481
120TCF7_22412390_ChIP-Seq_EML_Mouse0.97997480
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97732771
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97317699
123TP53_16413492_ChIP-PET_HCT116_Human0.96987208
124TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96813252
125RACK7_27058665_Chip-Seq_MCF-7_Human0.96686049
126TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96617286
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.95504018
128TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94767352
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94265956
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94265956
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94031780
132TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93678146
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.93290913
134STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92709284
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.92396964
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.92137507
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92044915
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91572611
139* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90046162
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89491091
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.88533091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.54784158
2MP0003705_abnormal_hypodermis_morpholog3.51693124
3MP0008438_abnormal_cutaneous_collagen3.35510678
4MP0010030_abnormal_orbit_morphology2.85250704
5MP0004858_abnormal_nervous_system2.77950990
6MP0004130_abnormal_muscle_cell2.64292474
7MP0000579_abnormal_nail_morphology2.58984658
8MP0009780_abnormal_chondrocyte_physiolo2.57961451
9MP0000751_myopathy2.48043764
10MP0003635_abnormal_synaptic_transmissio2.31391438
11MP0009053_abnormal_anal_canal2.26684002
12MP0005670_abnormal_white_adipose2.26010362
13MP0005623_abnormal_meninges_morphology2.14247015
14MP0000537_abnormal_urethra_morphology2.07347681
15MP0004270_analgesia2.07314636
16MP0008961_abnormal_basal_metabolism2.06852802
17MP0001849_ear_inflammation1.98089378
18MP0004233_abnormal_muscle_weight1.97196243
19MP0005257_abnormal_intraocular_pressure1.96992353
20MP0005409_darkened_coat_color1.91322226
21MP0002837_dystrophic_cardiac_calcinosis1.86777093
22MP0005275_abnormal_skin_tensile1.86182019
23MP0000013_abnormal_adipose_tissue1.82113443
24MP0004084_abnormal_cardiac_muscle1.80806248
25MP0005666_abnormal_adipose_tissue1.76985244
26MP0003279_aneurysm1.76462043
27MP0000566_synostosis1.75505440
28MP0004185_abnormal_adipocyte_glucose1.74394027
29MP0003941_abnormal_skin_development1.71576900
30MP0002697_abnormal_eye_size1.70442894
31MP0004272_abnormal_basement_membrane1.69492728
32MP0003045_fibrosis1.68056733
33MP0002063_abnormal_learning/memory/cond1.66762857
34MP0002653_abnormal_ependyma_morphology1.65236948
35MP0003136_yellow_coat_color1.65121634
36MP0000049_abnormal_middle_ear1.64352005
37MP0005375_adipose_tissue_phenotype1.63805110
38MP0002909_abnormal_adrenal_gland1.62621058
39MP0003942_abnormal_urinary_system1.58698605
40MP0000003_abnormal_adipose_tissue1.57274463
41MP0003937_abnormal_limbs/digits/tail_de1.54668739
42MP0000428_abnormal_craniofacial_morphol1.54526757
43MP0003283_abnormal_digestive_organ1.53790461
44MP0003119_abnormal_digestive_system1.51847960
45MP0000762_abnormal_tongue_morphology1.50970207
46MP0003300_gastrointestinal_ulcer1.48163038
47MP0002064_seizures1.47798282
48MP0004087_abnormal_muscle_fiber1.47513268
49MP0002249_abnormal_larynx_morphology1.47189543
50MP0000569_abnormal_digit_pigmentation1.42067393
51MP0001293_anophthalmia1.41069701
52MP0003861_abnormal_nervous_system1.41045167
53MP0003329_amyloid_beta_deposits1.40066516
54MP0003385_abnormal_body_wall1.39302190
55MP0002254_reproductive_system_inflammat1.38946664
56MP0009745_abnormal_behavioral_response1.38124232
57MP0004215_abnormal_myocardial_fiber1.37506857
58MP0003690_abnormal_glial_cell1.31864321
59MP0001299_abnormal_eye_distance/1.31077434
60MP0003755_abnormal_palate_morphology1.29642206
61MP0001958_emphysema1.28972504
62MP0001968_abnormal_touch/_nociception1.28889182
63MP0003566_abnormal_cell_adhesion1.27191459
64MP0004133_heterotaxia1.25504794
65MP0000747_muscle_weakness1.22325931
66MP0002233_abnormal_nose_morphology1.21718436
67MP0004145_abnormal_muscle_electrophysio1.21425659
68MP0005167_abnormal_blood-brain_barrier1.21171858
69MP0004885_abnormal_endolymph1.20588789
70MP0004036_abnormal_muscle_relaxation1.20362525
71MP0003091_abnormal_cell_migration1.19823790
72MP0006138_congestive_heart_failure1.19773198
73MP0004811_abnormal_neuron_physiology1.18999886
74MP0009046_muscle_twitch1.18489928
75MP0003075_altered_response_to1.17841608
76MP0008775_abnormal_heart_ventricle1.17289464
77MP0005620_abnormal_muscle_contractility1.15977406
78MP0002152_abnormal_brain_morphology1.15466099
79MP0006292_abnormal_olfactory_placode1.14446019
80MP0000750_abnormal_muscle_regeneration1.14418058
81MP0003935_abnormal_craniofacial_develop1.13961246
82MP0002092_abnormal_eye_morphology1.13227484
83MP0008569_lethality_at_weaning1.13191754
84MP0009384_cardiac_valve_regurgitation1.12845263
85MP0002972_abnormal_cardiac_muscle1.12243426
86MP0003122_maternal_imprinting1.12061922
87MP0000733_abnormal_muscle_development1.11072574
88MP0001501_abnormal_sleep_pattern1.09931801
89MP0003633_abnormal_nervous_system1.09861079
90MP0002116_abnormal_craniofacial_bone1.08865664
91MP0002572_abnormal_emotion/affect_behav1.08263206
92MP0009672_abnormal_birth_weight1.08144356
93MP0002734_abnormal_mechanical_nocicepti1.07203259
94MP0005503_abnormal_tendon_morphology1.06308842
95MP0002089_abnormal_postnatal_growth/wei1.06155993
96MP0005248_abnormal_Harderian_gland1.06134857
97MP0000759_abnormal_skeletal_muscle1.05978359
98MP0010630_abnormal_cardiac_muscle1.05803006
99MP0000432_abnormal_head_morphology1.05025253
100MP0005394_taste/olfaction_phenotype1.04408211
101MP0005499_abnormal_olfactory_system1.04408211
102MP0000534_abnormal_ureter_morphology1.03286647
103MP0002090_abnormal_vision1.02441644
104MP0010234_abnormal_vibrissa_follicle1.00542970
105MP0005076_abnormal_cell_differentiation1.00374516
106MP0002084_abnormal_developmental_patter1.00068256
107MP0003172_abnormal_lysosome_physiology0.99259958
108MP0003880_abnormal_central_pattern0.99019360
109MP0002234_abnormal_pharynx_morphology0.98333221
110MP0002085_abnormal_embryonic_tissue0.96409598
111MP0004085_abnormal_heartbeat0.96080558
112MP0003137_abnormal_impulse_conducting0.95660376
113MP0009250_abnormal_appendicular_skeleto0.95653400
114MP0005385_cardiovascular_system_phenoty0.95168374
115MP0001544_abnormal_cardiovascular_syste0.95168374
116MP0002269_muscular_atrophy0.95023332
117MP0002081_perinatal_lethality0.94462333
118MP0002733_abnormal_thermal_nociception0.94429090
119MP0003938_abnormal_ear_development0.93740616
120MP0001486_abnormal_startle_reflex0.93264078
121MP0000467_abnormal_esophagus_morphology0.92822617
122MP0005330_cardiomyopathy0.92445453
123MP0002108_abnormal_muscle_morphology0.92235661
124MP0000955_abnormal_spinal_cord0.92172762
125MP0001286_abnormal_eye_development0.91351858
126MP0005423_abnormal_somatic_nervous0.91054620
127MP0004197_abnormal_fetal_growth/weight/0.91024600
128MP0002111_abnormal_tail_morphology0.89746317
129MP0002882_abnormal_neuron_morphology0.88704694
130MP0000749_muscle_degeneration0.86974087
131MP0001915_intracranial_hemorrhage0.86634670
132MP0008789_abnormal_olfactory_epithelium0.86442874
133MP0002896_abnormal_bone_mineralization0.85828699
134MP0000778_abnormal_nervous_system0.85120719
135MP0005377_hearing/vestibular/ear_phenot0.85065966
136MP0003878_abnormal_ear_physiology0.85065966
137MP0000604_amyloidosis0.84915508
138MP0004484_altered_response_of0.84852880
139MP0002736_abnormal_nociception_after0.84143934
140MP0002822_catalepsy0.83374944
141MP0003303_peritoneal_inflammation0.82163279
142MP0001984_abnormal_olfaction0.82044682
143MP0003890_abnormal_embryonic-extraembry0.81869857
144MP0004510_myositis0.81078593
145MP0005197_abnormal_uvea_morphology0.80956010
146MP0010368_abnormal_lymphatic_system0.80339077
147MP0003634_abnormal_glial_cell0.80153942
148MP0002932_abnormal_joint_morphology0.79801555
149MP0005187_abnormal_penis_morphology0.78870847
150MP0001970_abnormal_pain_threshold0.78678432
151MP0000767_abnormal_smooth_muscle0.78376637
152MP0005508_abnormal_skeleton_morphology0.77889960
153MP0002272_abnormal_nervous_system0.77623893
154MP0002106_abnormal_muscle_physiology0.77496774
155MP0002971_abnormal_brown_adipose0.77143826
156MP0002184_abnormal_innervation0.76615739
157MP0003115_abnormal_respiratory_system0.74845612
158MP0005369_muscle_phenotype0.74371211
159MP0002114_abnormal_axial_skeleton0.72946950
160MP0001177_atelectasis0.72685521
161MP0002925_abnormal_cardiovascular_devel0.70924445

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.83698243
2Shallow orbits (HP:0000586)3.40564891
3Protrusio acetabuli (HP:0003179)3.38508935
4Broad metatarsal (HP:0001783)3.18048563
5Myokymia (HP:0002411)2.72950825
6Action tremor (HP:0002345)2.71823109
7Aortic aneurysm (HP:0004942)2.70611755
8Coronal craniosynostosis (HP:0004440)2.67975346
9Cutaneous finger syndactyly (HP:0010554)2.63933428
10Mitral valve prolapse (HP:0001634)2.58377550
11Premature rupture of membranes (HP:0001788)2.57009642
12Ulnar bowing (HP:0003031)2.56701678
13Striae distensae (HP:0001065)2.55250540
14Cutaneous syndactyly (HP:0012725)2.53882509
15Urethral obstruction (HP:0000796)2.53714682
16Hyperacusis (HP:0010780)2.53045644
17Aortic dissection (HP:0002647)2.50078313
18Bladder diverticulum (HP:0000015)2.47621187
19Distal upper limb amyotrophy (HP:0007149)2.47582524
20Upper limb amyotrophy (HP:0009129)2.47582524
21Focal seizures (HP:0007359)2.45747507
22Bronchomalacia (HP:0002780)2.44092343
23Dilatation of the ascending aorta (HP:0005111)2.41830118
24Difficulty running (HP:0009046)2.40446429
25Vertebral arch anomaly (HP:0008438)2.38278042
26Hemiplegia (HP:0002301)2.36971756
27Aneurysm (HP:0002617)2.31600537
28Arterial tortuosity (HP:0005116)2.31532659
29Ankle contracture (HP:0006466)2.31308732
30Dysmetric saccades (HP:0000641)2.29594120
31Abnormality of the lower motor neuron (HP:0002366)2.24728023
32Visual hallucinations (HP:0002367)2.24025777
33Broad thumb (HP:0011304)2.24010331
34Enlarged penis (HP:0000040)2.23679338
35Increased variability in muscle fiber diameter (HP:0003557)2.23315882
36Insomnia (HP:0100785)2.21723501
37Vascular tortuosity (HP:0004948)2.21467037
38Bowel diverticulosis (HP:0005222)2.21216235
39High anterior hairline (HP:0009890)2.20345472
40Preaxial foot polydactyly (HP:0001841)2.19688097
41Sudden death (HP:0001699)2.19543141
42Elfin facies (HP:0004428)2.16386108
43Overriding aorta (HP:0002623)2.15953272
44Macroorchidism (HP:0000053)2.15667264
45Supranuclear gaze palsy (HP:0000605)2.15640676
46Lymphangioma (HP:0100764)2.14693250
47Hyporeflexia of lower limbs (HP:0002600)2.14390462
48Focal motor seizures (HP:0011153)2.14283855
49Partial duplication of thumb phalanx (HP:0009944)2.14225390
50Increased connective tissue (HP:0009025)2.14013145
51Hand muscle atrophy (HP:0009130)2.12683018
52Vitreoretinal degeneration (HP:0000655)2.12055027
53Type 1 muscle fiber predominance (HP:0003803)2.09836636
54Trigonocephaly (HP:0000243)2.09785922
55Achilles tendon contracture (HP:0001771)2.08807063
56Pointed chin (HP:0000307)2.08682286
57Bundle branch block (HP:0011710)2.08010208
58Difficulty climbing stairs (HP:0003551)2.07000550
59Depression (HP:0000716)2.05448311
60Partial duplication of the phalanx of hand (HP:0009999)2.03335507
61Genu recurvatum (HP:0002816)2.02099039
62Buphthalmos (HP:0000557)2.01371467
63Insidious onset (HP:0003587)1.99770286
64Termporal pattern (HP:0011008)1.99770286
65Choanal stenosis (HP:0000452)1.99185202
66Abnormality of the distal phalanx of the thumb (HP:0009617)1.99146019
67Ventricular fibrillation (HP:0001663)1.97372540
68Turricephaly (HP:0000262)1.96190583
69Neoplasm of the heart (HP:0100544)1.95865801
70Mutism (HP:0002300)1.95483754
71Renal duplication (HP:0000075)1.94390287
72Vertebral clefting (HP:0008428)1.93495955
73Ankle clonus (HP:0011448)1.92886768
74Lower limb amyotrophy (HP:0007210)1.92635031
75Broad long bones (HP:0005622)1.92240907
76Broad finger (HP:0001500)1.92060060
77Broad phalanges of the hand (HP:0009768)1.91813943
78Hypercortisolism (HP:0001578)1.91382066
79Cortical dysplasia (HP:0002539)1.91133654
80Abnormality of the phalanges of the hallux (HP:0010057)1.91067478
81Abnormality of dentin (HP:0010299)1.90953392
82Renovascular hypertension (HP:0100817)1.90149499
83Abnormality of the aortic arch (HP:0012303)1.89837032
84Scapular winging (HP:0003691)1.88637950
85Postural instability (HP:0002172)1.88431654
86Abnormality of the Achilles tendon (HP:0005109)1.88219440
87Atrophic scars (HP:0001075)1.87757131
88Neonatal short-limb short stature (HP:0008921)1.87117339
89Abnormality of the 4th metacarpal (HP:0010012)1.87047324
90Thin ribs (HP:0000883)1.86841221
91Morphological abnormality of the middle ear (HP:0008609)1.86167986
92Abnormality of skeletal muscle fiber size (HP:0012084)1.85373351
93Rapidly progressive (HP:0003678)1.84832738
94Deviation of the hallux (HP:0010051)1.84789576
95Skull defect (HP:0001362)1.83936969
96Exercise-induced myalgia (HP:0003738)1.83601769
97Broad phalanx (HP:0006009)1.83353074
98Abnormal social behavior (HP:0012433)1.82131407
99Impaired social interactions (HP:0000735)1.82131407
100Split foot (HP:0001839)1.80674081
101Overgrowth (HP:0001548)1.80291779
102Wide anterior fontanel (HP:0000260)1.79648169
103Myelomeningocele (HP:0002475)1.79075328
104Cerebral inclusion bodies (HP:0100314)1.79006561
105Impaired vibration sensation in the lower limbs (HP:0002166)1.78631646
106Long toe (HP:0010511)1.78133734
107Hallux valgus (HP:0001822)1.77879769
108Hypoventilation (HP:0002791)1.77715025
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77592473
110Short 4th metacarpal (HP:0010044)1.77592473
111Disproportionate tall stature (HP:0001519)1.77335645
112Hyperextensible skin (HP:0000974)1.77107310
113Resting tremor (HP:0002322)1.76639141
114Asymmetric septal hypertrophy (HP:0001670)1.76230967
115Urinary bladder sphincter dysfunction (HP:0002839)1.76220779
116Flat cornea (HP:0007720)1.75224362
117Peritonitis (HP:0002586)1.75214945
118Milia (HP:0001056)1.74846313
119Mildly elevated creatine phosphokinase (HP:0008180)1.74434016
120Myotonia (HP:0002486)1.74270759
121Fragile skin (HP:0001030)1.73219635
122Spinal rigidity (HP:0003306)1.73016269
123Megalencephaly (HP:0001355)1.72886980
124Hepatoblastoma (HP:0002884)1.72794939
125Septo-optic dysplasia (HP:0100842)1.72290713
126Genetic anticipation (HP:0003743)1.71829680
127Duplication of thumb phalanx (HP:0009942)1.70846794
128Obstructive sleep apnea (HP:0002870)1.70789607
129Prolonged QT interval (HP:0001657)1.69636352
130Neurofibrillary tangles (HP:0002185)1.69301463
131Tracheomalacia (HP:0002779)1.68911935
132Arnold-Chiari malformation (HP:0002308)1.68379546
133Abnormality of the diencephalon (HP:0010662)1.67745833
134Megalocornea (HP:0000485)1.67602865
135Poor eye contact (HP:0000817)1.66567573
136Papilledema (HP:0001085)1.66566135
137Hammertoe (HP:0001765)1.66383722
138Exercise-induced muscle cramps (HP:0003710)1.65263473
139Urinary urgency (HP:0000012)1.64992481
140Narrow palate (HP:0000189)1.64764543
141Abnormal eating behavior (HP:0100738)1.64608549
142Aplasia of the phalanges of the hand (HP:0009802)1.64061510
143Aplasia involving bones of the extremities (HP:0009825)1.64061510
144Aplasia involving bones of the upper limbs (HP:0009823)1.64061510
145Bilateral microphthalmos (HP:0007633)1.63438650
146Torticollis (HP:0000473)1.63432630
147Fragile nails (HP:0001808)1.62165978
148Spina bifida occulta (HP:0003298)1.61981204
149Abnormality of the ischium (HP:0003174)1.60756424
150Drooling (HP:0002307)1.59377994
151Bowed forearm bones (HP:0003956)1.56137292
152Bowing of the arm (HP:0006488)1.56137292
153Esophageal atresia (HP:0002032)1.55273689
154Abnormality of the calcaneus (HP:0008364)1.54843455
155Limited hip movement (HP:0008800)1.53908497
156Mitral regurgitation (HP:0001653)1.53793793
157Selective tooth agenesis (HP:0001592)1.52449896
158Broad distal phalanx of finger (HP:0009836)1.50892338
159Shawl scrotum (HP:0000049)1.49032098
160Anophthalmia (HP:0000528)1.48712727
161Anterior segment dysgenesis (HP:0007700)1.47884797
162Excessive salivation (HP:0003781)1.45147374
163Omphalocele (HP:0001539)1.44660939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.37696217
2MAP3K92.88921048
3PKN22.77533065
4RIPK12.63764941
5CASK2.22050394
6PRKD32.21996349
7PAK62.12301421
8CAMK1G2.10919248
9NTRK32.09104750
10PDGFRA2.05047998
11KSR22.03984999
12CAMK1D2.01802150
13CAMKK11.94621329
14DAPK21.93518580
15CDK121.89365326
16LMTK21.89270293
17LATS21.84542165
18EPHA41.84075140
19TTN1.69963011
20NTRK11.69372597
21SIK11.69008458
22MINK11.52707196
23PHKG21.50998452
24PHKG11.50998452
25RET1.49519061
26CDK191.44791374
27DMPK1.43680370
28DDR21.43520348
29MAP3K41.38965409
30ERN11.36662349
31EEF2K1.36256628
32TAOK11.35799764
33TYRO31.35316647
34MARK11.34790765
35STK381.25754446
36PRKCH1.24991025
37SCYL21.22847457
38NTRK21.19851265
39MET1.18149803
40TGFBR21.17672889
41EPHB11.11221736
42MAP3K71.10292466
43KSR11.09256249
44ERBB41.08744255
45NEK11.07460707
46MAP2K41.07415402
47PTK61.05574934
48SIK21.01176971
49ALK0.99617647
50TIE10.98294223
51DYRK20.95655042
52SMG10.94953044
53MAP3K20.94212391
54PAK20.94055252
55BMX0.94032168
56CDK50.92922869
57ICK0.92640801
58NEK20.92045393
59PAK30.90875266
60PTK2B0.89666869
61STK38L0.88521380
62DYRK1B0.88288636
63CAMKK20.85864178
64ROCK20.85801031
65PDGFRB0.85694314
66PNCK0.85651837
67LATS10.84367083
68FGFR20.83904384
69SGK30.80167407
70FER0.79850260
71CDC42BPA0.79246262
72UHMK10.78857582
73BRD40.78091110
74PTK20.77484486
75FGFR10.76513794
76MARK20.76229813
77TNIK0.75874107
78MTOR0.75812805
79MAP3K100.74997280
80MOS0.73032805
81FGFR30.69198472
82MAP2K10.69108558
83EPHB20.67142667
84PDPK10.66401784
85PDK10.65923120
86PRKD10.65888844
87STK110.65785190
88DYRK1A0.65680729
89CAMK10.65519940
90CAMK40.65064934
91MAPK120.64435693
92RPS6KL10.64062400
93RPS6KC10.64062400
94RPS6KA60.61791689
95DAPK10.59331076
96JAK10.59286079
97ERBB20.56527574
98ROCK10.55715200
99MAPK100.54106233
100SGK20.54082075
101ARAF0.53503380
102RPS6KA20.53191776
103CDK11A0.52956284
104MAP3K10.52790738
105CDK150.49140518
106STK30.48772733
107CDK140.48522049
108DAPK30.48485549
109FGFR40.47535864
110CDK180.45063964
111PLK20.44825726
112PAK40.44189408
113RPS6KA10.43865113
114SRC0.43620277
115JAK20.43550020
116RPS6KA30.43525038
117NEK90.42938305
118WNK10.42907474
119PRKAA10.42635745
120STK240.42052018
121GRK50.41788971
122ILK0.41643852
123DYRK30.41263353
124FYN0.41193642
125FLT30.40808535
126PRKCG0.40421924
127PRKD20.39817719
128EPHA30.39807581
129LIMK10.38821278
130SGK4940.38766024
131SGK2230.38766024
132SGK10.38510704
133MAP3K130.38341065
134PRKCZ0.38162195

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.32932047
2Basal cell carcinoma_Homo sapiens_hsa052172.09351858
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89652567
4Notch signaling pathway_Homo sapiens_hsa043301.79257414
5Hedgehog signaling pathway_Homo sapiens_hsa043401.72021707
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.71035953
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59263519
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55912279
9Synaptic vesicle cycle_Homo sapiens_hsa047211.54844345
10Dilated cardiomyopathy_Homo sapiens_hsa054141.52136414
11Circadian entrainment_Homo sapiens_hsa047131.48576616
12Salivary secretion_Homo sapiens_hsa049701.43944627
13Olfactory transduction_Homo sapiens_hsa047401.43475449
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41712532
15Long-term potentiation_Homo sapiens_hsa047201.40322594
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39498797
17Gastric acid secretion_Homo sapiens_hsa049711.37685773
18Glioma_Homo sapiens_hsa052141.35269182
19Renin secretion_Homo sapiens_hsa049241.33248830
20GABAergic synapse_Homo sapiens_hsa047271.32222407
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31726561
22Wnt signaling pathway_Homo sapiens_hsa043101.30936768
23Insulin secretion_Homo sapiens_hsa049111.30270670
24MicroRNAs in cancer_Homo sapiens_hsa052061.30076887
25Oxytocin signaling pathway_Homo sapiens_hsa049211.27808610
26Lysine degradation_Homo sapiens_hsa003101.25241168
27Type II diabetes mellitus_Homo sapiens_hsa049301.23027399
28Glutamatergic synapse_Homo sapiens_hsa047241.22949385
29Tight junction_Homo sapiens_hsa045301.21665114
30Cholinergic synapse_Homo sapiens_hsa047251.19739434
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19293978
32mTOR signaling pathway_Homo sapiens_hsa041501.19017846
33Morphine addiction_Homo sapiens_hsa050321.18948926
34Pancreatic secretion_Homo sapiens_hsa049721.18793882
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18750661
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15741058
37Estrogen signaling pathway_Homo sapiens_hsa049151.15135853
38Nicotine addiction_Homo sapiens_hsa050331.14828699
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13778069
40GnRH signaling pathway_Homo sapiens_hsa049121.11455658
41Focal adhesion_Homo sapiens_hsa045101.11054729
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10786224
43Dopaminergic synapse_Homo sapiens_hsa047281.10646417
44Gap junction_Homo sapiens_hsa045401.10055897
45Fatty acid biosynthesis_Homo sapiens_hsa000611.09588465
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08731383
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06106109
48Amphetamine addiction_Homo sapiens_hsa050311.05455646
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04696331
50cAMP signaling pathway_Homo sapiens_hsa040241.03037866
51Insulin signaling pathway_Homo sapiens_hsa049101.02819343
52Bladder cancer_Homo sapiens_hsa052191.00849300
53Protein digestion and absorption_Homo sapiens_hsa049741.00827152
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.00639932
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98374632
56Proteoglycans in cancer_Homo sapiens_hsa052050.97243061
57Pathways in cancer_Homo sapiens_hsa052000.96512750
58Endometrial cancer_Homo sapiens_hsa052130.94741675
59* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93867360
60Dorso-ventral axis formation_Homo sapiens_hsa043200.93825028
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93586882
62Calcium signaling pathway_Homo sapiens_hsa040200.93089204
63Melanoma_Homo sapiens_hsa052180.92841185
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.92438428
65Cocaine addiction_Homo sapiens_hsa050300.91652315
66ErbB signaling pathway_Homo sapiens_hsa040120.91475096
67VEGF signaling pathway_Homo sapiens_hsa043700.91452258
68Ras signaling pathway_Homo sapiens_hsa040140.91272731
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.90738255
70Small cell lung cancer_Homo sapiens_hsa052220.89542458
71Insulin resistance_Homo sapiens_hsa049310.89456527
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.88860819
73ECM-receptor interaction_Homo sapiens_hsa045120.88852034
74Melanogenesis_Homo sapiens_hsa049160.88416736
75Axon guidance_Homo sapiens_hsa043600.87815932
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87445392
77Chronic myeloid leukemia_Homo sapiens_hsa052200.87079988
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84779427
79Glucagon signaling pathway_Homo sapiens_hsa049220.84539313
80AMPK signaling pathway_Homo sapiens_hsa041520.83665531
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82325421
82Renal cell carcinoma_Homo sapiens_hsa052110.81860310
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81481967
84Non-small cell lung cancer_Homo sapiens_hsa052230.80246183
85Rap1 signaling pathway_Homo sapiens_hsa040150.79970186
86Long-term depression_Homo sapiens_hsa047300.79107449
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77919817
88Adherens junction_Homo sapiens_hsa045200.76696881
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76645517
90Amoebiasis_Homo sapiens_hsa051460.75731395
91Bile secretion_Homo sapiens_hsa049760.75338449
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74115059
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73792532
94TGF-beta signaling pathway_Homo sapiens_hsa043500.73488661
95PPAR signaling pathway_Homo sapiens_hsa033200.72655469
96Prostate cancer_Homo sapiens_hsa052150.72287664
97Colorectal cancer_Homo sapiens_hsa052100.72271634
98Thyroid cancer_Homo sapiens_hsa052160.72152288
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70843805
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.70737273
101Endocytosis_Homo sapiens_hsa041440.69954604
102Prion diseases_Homo sapiens_hsa050200.68806267
103MAPK signaling pathway_Homo sapiens_hsa040100.66278207
104Pancreatic cancer_Homo sapiens_hsa052120.65786083
105Viral myocarditis_Homo sapiens_hsa054160.65059022
106Taste transduction_Homo sapiens_hsa047420.64919815
107Inositol phosphate metabolism_Homo sapiens_hsa005620.64872312
108Glycerolipid metabolism_Homo sapiens_hsa005610.64234488
109Platelet activation_Homo sapiens_hsa046110.63953113
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62691165
111Choline metabolism in cancer_Homo sapiens_hsa052310.62339564
112HIF-1 signaling pathway_Homo sapiens_hsa040660.61938043
113Thyroid hormone synthesis_Homo sapiens_hsa049180.61695464
114Hippo signaling pathway_Homo sapiens_hsa043900.61321989
115Serotonergic synapse_Homo sapiens_hsa047260.61037348
116FoxO signaling pathway_Homo sapiens_hsa040680.60886461
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59591806
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58711655
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58590514
120Fatty acid metabolism_Homo sapiens_hsa012120.58532136
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58197091
122Arginine biosynthesis_Homo sapiens_hsa002200.57418718
123Prolactin signaling pathway_Homo sapiens_hsa049170.52626669
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.50846340
125Ovarian steroidogenesis_Homo sapiens_hsa049130.50745422
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50357525
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.50110635

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