EXTL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.64960060
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39116662
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.05715480
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.03583767
5vocalization behavior (GO:0071625)5.02050032
6regulation of synaptic vesicle exocytosis (GO:2000300)5.00568916
7glutamate secretion (GO:0014047)4.94112435
8synaptic vesicle maturation (GO:0016188)4.89609983
9locomotory exploration behavior (GO:0035641)4.84131040
10neuronal action potential propagation (GO:0019227)4.81197831
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.75063495
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73029095
13protein localization to synapse (GO:0035418)4.71552185
14regulation of glutamate receptor signaling pathway (GO:1900449)4.63640513
15neuron cell-cell adhesion (GO:0007158)4.63347634
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.62781917
17neurotransmitter secretion (GO:0007269)4.49878104
18neurotransmitter-gated ion channel clustering (GO:0072578)4.49202834
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.40885175
20neuron-neuron synaptic transmission (GO:0007270)4.37350044
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.36142173
22synaptic transmission, glutamatergic (GO:0035249)4.31640873
23regulation of synaptic vesicle transport (GO:1902803)4.29366879
24chromatin remodeling at centromere (GO:0031055)4.17159251
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.15965161
26glutamate receptor signaling pathway (GO:0007215)4.14046652
27presynaptic membrane assembly (GO:0097105)4.03381790
28CENP-A containing nucleosome assembly (GO:0034080)4.02862255
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96170725
30positive regulation of synapse maturation (GO:0090129)3.90139450
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.89968271
32postsynaptic membrane organization (GO:0001941)3.85836190
33gamma-aminobutyric acid transport (GO:0015812)3.85750189
34establishment of integrated proviral latency (GO:0075713)3.83343066
35exploration behavior (GO:0035640)3.80588705
36presynaptic membrane organization (GO:0097090)3.77551606
37long-term synaptic potentiation (GO:0060291)3.76941647
38cerebellar granule cell differentiation (GO:0021707)3.70111814
39neurotransmitter transport (GO:0006836)3.65608550
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.63772366
41cellular potassium ion homeostasis (GO:0030007)3.63051672
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62243376
43regulation of neuronal synaptic plasticity (GO:0048168)3.59358011
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59208768
45DNA double-strand break processing (GO:0000729)3.54602666
46positive regulation of membrane potential (GO:0045838)3.52530183
47long-term memory (GO:0007616)3.50218679
48regulation of synaptic transmission, glutamatergic (GO:0051966)3.49530893
49histone exchange (GO:0043486)3.47140390
50regulation of postsynaptic membrane potential (GO:0060078)3.46966370
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46009619
52regulation of neurotransmitter secretion (GO:0046928)3.45118063
53neuromuscular process controlling posture (GO:0050884)3.44210323
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42936841
55regulation of synapse structural plasticity (GO:0051823)3.37311450
56regulation of neurotransmitter levels (GO:0001505)3.36549551
57cerebellar Purkinje cell differentiation (GO:0021702)3.35316101
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.35253658
59response to histamine (GO:0034776)3.33678788
60regulation of neurotransmitter transport (GO:0051588)3.31635122
61startle response (GO:0001964)3.29506083
62synaptic vesicle endocytosis (GO:0048488)3.29357141
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27450890
64regulation of synaptic plasticity (GO:0048167)3.24292285
65ATP hydrolysis coupled proton transport (GO:0015991)3.23605346
66energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.23605346
67membrane hyperpolarization (GO:0060081)3.22507227
68response to pheromone (GO:0019236)3.22449833
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.21914480
70mitotic metaphase plate congression (GO:0007080)3.20224351
71transmission of nerve impulse (GO:0019226)3.19788251
72activation of protein kinase A activity (GO:0034199)3.18948709
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.18807830
74DNA replication-independent nucleosome assembly (GO:0006336)3.17923727
75DNA replication-independent nucleosome organization (GO:0034724)3.17923727
76regulation of voltage-gated calcium channel activity (GO:1901385)3.16721804
77regulation of vesicle fusion (GO:0031338)3.16675656
78membrane depolarization during action potential (GO:0086010)3.15729228
79DNA ligation (GO:0006266)3.14190734
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13713434
81behavioral response to cocaine (GO:0048148)3.13319030
82sodium ion export (GO:0071436)3.12927701
83membrane depolarization (GO:0051899)3.12625958
84synaptic transmission (GO:0007268)3.12180882
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11862502
86positive regulation of neurotransmitter transport (GO:0051590)3.10797806
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10731327
88striatum development (GO:0021756)3.10645383
89positive regulation of synaptic transmission (GO:0050806)3.08313480
90transferrin transport (GO:0033572)3.08290723
91regulation of synapse maturation (GO:0090128)3.07269710
92metaphase plate congression (GO:0051310)3.05575284
93proline transport (GO:0015824)3.04029276
94synapse assembly (GO:0007416)3.03785340
95protein localization to kinetochore (GO:0034501)3.03651913
96neuron recognition (GO:0008038)3.02090209
97layer formation in cerebral cortex (GO:0021819)3.01653152
98regulation of synaptic transmission, GABAergic (GO:0032228)3.01582897
99positive regulation of synapse assembly (GO:0051965)3.01264583
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.00411252
101innervation (GO:0060384)2.96163750
102negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93342425
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.93342425
104negative regulation of sister chromatid segregation (GO:0033046)2.93342425
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93342425
106negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93342425
107mechanosensory behavior (GO:0007638)2.93134582
108regulation of synaptic transmission (GO:0050804)2.92700242
109cullin deneddylation (GO:0010388)2.92405656
110auditory behavior (GO:0031223)2.92183836
111learning (GO:0007612)2.91641295
112spindle checkpoint (GO:0031577)2.91496376
113long term synaptic depression (GO:0060292)2.89649897
114trivalent inorganic cation transport (GO:0072512)2.89283528
115ferric iron transport (GO:0015682)2.89283528
116adult walking behavior (GO:0007628)2.89069177
117response to auditory stimulus (GO:0010996)2.89056069
118establishment of synaptic vesicle localization (GO:0097480)2.88822443
119synaptic vesicle transport (GO:0048489)2.88822443
120mitotic spindle checkpoint (GO:0071174)2.87753640
121negative regulation of chromosome segregation (GO:0051985)2.84463671
122detection of calcium ion (GO:0005513)2.84100292
123L-serine metabolic process (GO:0006563)2.79941014
124establishment of viral latency (GO:0019043)2.79745273
125negative regulation of DNA-dependent DNA replication (GO:2000104)2.78301375
126kinetochore organization (GO:0051383)2.78012103
127ATP synthesis coupled proton transport (GO:0015986)2.77938829
128energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77938829
129IMP biosynthetic process (GO:0006188)2.77794725
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.74861932
131mitotic spindle assembly checkpoint (GO:0007094)2.73230249
132chaperone-mediated protein transport (GO:0072321)2.73015110
133paraxial mesoderm development (GO:0048339)2.72403517
134spindle assembly checkpoint (GO:0071173)2.69332673
135protein neddylation (GO:0045116)2.68836659
136non-recombinational repair (GO:0000726)2.67341178
137double-strand break repair via nonhomologous end joining (GO:0006303)2.67341178
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66731912
139nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66083599
140regulation of centriole replication (GO:0046599)2.64774195
141replication fork processing (GO:0031297)2.63483586
142DNA damage response, detection of DNA damage (GO:0042769)2.62825954
143resolution of meiotic recombination intermediates (GO:0000712)2.60164200
144regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59785407
145regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59785407
146DNA replication checkpoint (GO:0000076)2.59371513
147regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58595557
148regulation of mitotic spindle checkpoint (GO:1903504)2.58595557
149negative regulation of DNA recombination (GO:0045910)2.57844185
150mitotic G2/M transition checkpoint (GO:0044818)2.57251188
151regulation of mitotic sister chromatid separation (GO:0010965)2.57082672
152regulation of mitotic sister chromatid segregation (GO:0033047)2.57082672
153regulation of sister chromatid segregation (GO:0033045)2.57082672
154proteasome assembly (GO:0043248)2.55199609
155kinetochore assembly (GO:0051382)2.55080408
156protein deneddylation (GO:0000338)2.54541796
157otic vesicle formation (GO:0030916)2.50944420
158purine nucleobase biosynthetic process (GO:0009113)2.48505911
159lateral sprouting from an epithelium (GO:0060601)2.47568985
160anterior/posterior axis specification, embryo (GO:0008595)2.46331012
161negative regulation of mitosis (GO:0045839)2.45594059
162IMP metabolic process (GO:0046040)2.43839765
163regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43448623
164DNA replication-dependent nucleosome assembly (GO:0006335)2.42247347
165DNA replication-dependent nucleosome organization (GO:0034723)2.42247347
166regulation of helicase activity (GO:0051095)2.41368996
167DNA strand elongation involved in DNA replication (GO:0006271)2.40784770
168DNA catabolic process, exonucleolytic (GO:0000738)2.37326162
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.37094681
170regulation of chromosome segregation (GO:0051983)2.37066728
171protein localization to chromosome, centromeric region (GO:0071459)2.36432982
172negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.35288455
173telomere maintenance via semi-conservative replication (GO:0032201)2.33377479
174ATP-dependent chromatin remodeling (GO:0043044)2.33316933
175regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.32856104
176somite development (GO:0061053)2.31863014
177ventricular cardiac muscle cell development (GO:0055015)2.30446175
178maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.29748213
179sister chromatid segregation (GO:0000819)2.29644158
180regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.29218413
181DNA strand elongation (GO:0022616)2.27995915
182intraciliary transport (GO:0042073)2.27391895
183mitotic sister chromatid segregation (GO:0000070)2.26284612
184somatic diversification of immune receptors via somatic mutation (GO:0002566)2.25162318
185somatic hypermutation of immunoglobulin genes (GO:0016446)2.25162318
186anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.24766228
187regulation of non-canonical Wnt signaling pathway (GO:2000050)2.24530956
188establishment of chromosome localization (GO:0051303)2.24467049
189response to X-ray (GO:0010165)2.23185027
190limb bud formation (GO:0060174)2.23008157
191nucleobase biosynthetic process (GO:0046112)2.21945334
192mitotic G2 DNA damage checkpoint (GO:0007095)2.21031409
193spliceosomal snRNP assembly (GO:0000387)2.19640644
194regulation of mitochondrial translation (GO:0070129)2.19346833
195mitotic recombination (GO:0006312)2.19059747
196negative regulation of nuclear division (GO:0051784)2.18150151
197protein-cofactor linkage (GO:0018065)2.15386127
198female gonad development (GO:0008585)2.15069307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22594059
2GBX2_23144817_ChIP-Seq_PC3_Human4.38146102
3E2F7_22180533_ChIP-Seq_HELA_Human3.38492775
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.23129199
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22803017
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07518756
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93875531
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.92569173
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80868363
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64143906
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63470876
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63470876
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60669245
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59754556
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59471738
16REST_21632747_ChIP-Seq_MESCs_Mouse2.58180168
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53431368
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51971310
19TAF15_26573619_Chip-Seq_HEK293_Human2.48007144
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.47053965
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46879112
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44443686
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.43196557
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41896958
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.41107176
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.35377343
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34288071
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.26829592
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.21692236
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19190501
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.17973783
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15614857
33* MYC_18555785_ChIP-Seq_MESCs_Mouse2.14936076
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.14675894
35EWS_26573619_Chip-Seq_HEK293_Human2.12541295
36SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12412917
37ELK1_19687146_ChIP-ChIP_HELA_Human2.10688380
38DROSHA_22980978_ChIP-Seq_HELA_Human2.08977141
39POU5F1_16153702_ChIP-ChIP_HESCs_Human2.06901035
40RNF2_27304074_Chip-Seq_ESCs_Mouse2.05968520
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01956597
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98403257
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97451437
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95244461
45SMAD4_21799915_ChIP-Seq_A2780_Human1.92646487
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92451398
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89035646
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88234512
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87998804
50AR_21572438_ChIP-Seq_LNCaP_Human1.87216354
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86155478
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85180191
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79097891
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74170279
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74073499
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73674788
57P300_19829295_ChIP-Seq_ESCs_Human1.72052300
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66173759
59AR_21909140_ChIP-Seq_LNCAP_Human1.64572733
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.62971039
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58106405
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.55659716
63* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54859252
64* NANOG_16153702_ChIP-ChIP_HESCs_Human1.50889393
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49283014
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48144347
67ZNF274_21170338_ChIP-Seq_K562_Hela1.47189856
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46745013
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45090821
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44018663
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.42525593
72IGF1R_20145208_ChIP-Seq_DFB_Human1.41694271
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.41476177
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40670735
75AR_25329375_ChIP-Seq_VCAP_Human1.40592886
76MYC_18940864_ChIP-ChIP_HL60_Human1.40541432
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.39698887
78* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38427374
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38317281
80FUS_26573619_Chip-Seq_HEK293_Human1.37567542
81VDR_22108803_ChIP-Seq_LS180_Human1.37114120
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36482074
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.36372763
84* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35007727
85STAT3_23295773_ChIP-Seq_U87_Human1.33294858
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33185273
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.31061960
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30599050
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28954213
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28656048
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27714756
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27083358
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27071584
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25994350
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25118295
96ER_23166858_ChIP-Seq_MCF-7_Human1.24896139
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24367203
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.20663506
99TCF4_23295773_ChIP-Seq_U87_Human1.19512252
100RNF2_27304074_Chip-Seq_NSC_Mouse1.19109560
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15983230
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15434513
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15181871
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14880565
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.14117190
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13749343
107* TTF2_22483619_ChIP-Seq_HELA_Human1.12510835
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.11961306
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11918035
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11884114
111AR_19668381_ChIP-Seq_PC3_Human1.11816441
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11594426
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11499398
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10476673
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10200139
116* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09296121
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08938203
118VDR_23849224_ChIP-Seq_CD4+_Human1.07190796
119JUN_21703547_ChIP-Seq_K562_Human1.06751906
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.06670949
121E2F1_21310950_ChIP-Seq_MCF-7_Human1.06369937
122* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06261657
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06150554
124RUNX2_22187159_ChIP-Seq_PCA_Human1.05304841
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04777412
126FOXP3_21729870_ChIP-Seq_TREG_Human1.04490658
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.03542151
128MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03252127
129YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03243441
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03104374
131E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03084781
132* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01292844
133EZH2_27294783_Chip-Seq_NPCs_Mouse1.00490574
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00472126
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99969537
136PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98541182
137WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97956579
138NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97900910
139BCAT_22108803_ChIP-Seq_LS180_Human0.97779245
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97578359
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97515420
142KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97334149
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97092922
144ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97020352
145TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96546470
146TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96073012
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96010847
148* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94067284
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94011730
150FLI1_21867929_ChIP-Seq_TH2_Mouse0.93519111
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.93492558
152ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93059382
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92663914
154AHR_22903824_ChIP-Seq_MCF-7_Human0.92453847
155SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91587880
156* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91364755
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91121210
158SOX9_26525672_Chip-Seq_HEART_Mouse0.90597656
159TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88091312
160MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86992413
161KDM2B_26808549_Chip-Seq_REH_Human0.86267645
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.85903082
163CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83479374
164RING1B_27294783_Chip-Seq_NPCs_Mouse0.83371990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.22143444
2MP0003880_abnormal_central_pattern4.87784333
3MP0003635_abnormal_synaptic_transmissio3.91351111
4MP0009046_muscle_twitch3.60160319
5MP0009745_abnormal_behavioral_response3.36655135
6MP0002064_seizures3.29124818
7MP0004270_analgesia3.15361308
8MP0002063_abnormal_learning/memory/cond3.07776677
9MP0001968_abnormal_touch/_nociception3.06886081
10MP0002272_abnormal_nervous_system2.89758174
11MP0002572_abnormal_emotion/affect_behav2.78703209
12MP0010030_abnormal_orbit_morphology2.71549246
13MP0002736_abnormal_nociception_after2.61316809
14MP0002734_abnormal_mechanical_nocicepti2.58627367
15MP0001486_abnormal_startle_reflex2.54504617
16MP0002735_abnormal_chemical_nociception2.40203308
17MP0005423_abnormal_somatic_nervous2.35064127
18MP0003136_yellow_coat_color2.34981748
19MP0002822_catalepsy2.24406038
20MP0001501_abnormal_sleep_pattern2.22258821
21MP0003941_abnormal_skin_development2.19207576
22MP0002067_abnormal_sensory_capabilities2.18232041
23MP0006292_abnormal_olfactory_placode2.16940339
24MP0008058_abnormal_DNA_repair2.16041373
25MP0001293_anophthalmia2.10706051
26MP0001440_abnormal_grooming_behavior2.06388179
27MP0005646_abnormal_pituitary_gland2.03625019
28MP0002938_white_spotting2.03132552
29MP0003890_abnormal_embryonic-extraembry2.01907991
30MP0010094_abnormal_chromosome_stability1.97202561
31MP0008569_lethality_at_weaning1.91251961
32MP0001984_abnormal_olfaction1.90847831
33MP0001970_abnormal_pain_threshold1.90467937
34MP0003937_abnormal_limbs/digits/tail_de1.87434815
35MP0002733_abnormal_thermal_nociception1.85112651
36MP0004957_abnormal_blastocyst_morpholog1.84907551
37MP0009780_abnormal_chondrocyte_physiolo1.81390480
38MP0008932_abnormal_embryonic_tissue1.81009093
39MP0000049_abnormal_middle_ear1.80516967
40MP0006276_abnormal_autonomic_nervous1.75642852
41MP0002909_abnormal_adrenal_gland1.74783479
42MP0002184_abnormal_innervation1.73084895
43MP0005551_abnormal_eye_electrophysiolog1.73078462
44MP0003879_abnormal_hair_cell1.72306479
45MP0009697_abnormal_copulation1.71993105
46MP0003567_abnormal_fetal_cardiomyocyte1.65975917
47MP0002102_abnormal_ear_morphology1.64271014
48MP0002557_abnormal_social/conspecific_i1.62828778
49MP0004924_abnormal_behavior1.61636159
50MP0005386_behavior/neurological_phenoty1.61636159
51MP0003121_genomic_imprinting1.61499962
52MP0008789_abnormal_olfactory_epithelium1.61085190
53MP0001529_abnormal_vocalization1.60980715
54MP0003329_amyloid_beta_deposits1.60747775
55MP0002233_abnormal_nose_morphology1.58489639
56MP0003122_maternal_imprinting1.58438633
57MP0004142_abnormal_muscle_tone1.55226705
58MP0003787_abnormal_imprinting1.52417336
59MP0004811_abnormal_neuron_physiology1.48163305
60MP0002697_abnormal_eye_size1.47637998
61MP0003111_abnormal_nucleus_morphology1.47633239
62MP0004133_heterotaxia1.46197355
63MP0003119_abnormal_digestive_system1.46117486
64MP0000566_synostosis1.43044225
65MP0008877_abnormal_DNA_methylation1.42386447
66MP0000955_abnormal_spinal_cord1.41727647
67MP0002837_dystrophic_cardiac_calcinosis1.41505802
68MP0001905_abnormal_dopamine_level1.39855081
69MP0001286_abnormal_eye_development1.39788815
70MP0000013_abnormal_adipose_tissue1.39369484
71MP0002066_abnormal_motor_capabilities/c1.38882864
72MP0002882_abnormal_neuron_morphology1.38565831
73MP0003077_abnormal_cell_cycle1.37983191
74MP0001188_hyperpigmentation1.37276755
75MP0010386_abnormal_urinary_bladder1.36262842
76MP0004858_abnormal_nervous_system1.34627677
77MP0003755_abnormal_palate_morphology1.33879517
78MP0003693_abnormal_embryo_hatching1.33842276
79MP0009250_abnormal_appendicular_skeleto1.33206702
80MP0000778_abnormal_nervous_system1.32969111
81MP0001502_abnormal_circadian_rhythm1.31755818
82MP0003633_abnormal_nervous_system1.30624457
83MP0003942_abnormal_urinary_system1.30308987
84MP0003385_abnormal_body_wall1.29598855
85MP0000751_myopathy1.26499855
86MP0002751_abnormal_autonomic_nervous1.24337645
87MP0004233_abnormal_muscle_weight1.22078396
88MP0004145_abnormal_muscle_electrophysio1.21786944
89MP0003718_maternal_effect1.19869198
90MP0002282_abnormal_trachea_morphology1.19599029
91MP0004885_abnormal_endolymph1.19231803
92MP0002090_abnormal_vision1.16351435
93MP0002229_neurodegeneration1.15243719
94MP0005645_abnormal_hypothalamus_physiol1.15193065
95MP0000428_abnormal_craniofacial_morphol1.15155862
96MP0002234_abnormal_pharynx_morphology1.15021848
97MP0002084_abnormal_developmental_patter1.14147268
98MP0003283_abnormal_digestive_organ1.12769643
99MP0003631_nervous_system_phenotype1.10986897
100MP0003183_abnormal_peptide_metabolism1.10244448
101MP0008007_abnormal_cellular_replicative1.10227884
102MP0002085_abnormal_embryonic_tissue1.09128209
103MP0004272_abnormal_basement_membrane1.07092072
104MP0003861_abnormal_nervous_system1.06368515
105MP0000537_abnormal_urethra_morphology1.06183798
106MP0005084_abnormal_gallbladder_morpholo1.05987860
107MP0002638_abnormal_pupillary_reflex1.05402699
108MP0002876_abnormal_thyroid_physiology1.03793490
109MP0004215_abnormal_myocardial_fiber1.02029506
110MP0003315_abnormal_perineum_morphology0.99882414
111MP0002152_abnormal_brain_morphology0.96171311
112MP0003935_abnormal_craniofacial_develop0.96007514
113MP0001963_abnormal_hearing_physiology0.95421456
114MP0004085_abnormal_heartbeat0.95359810
115MP0004742_abnormal_vestibular_system0.95334086
116MP0005187_abnormal_penis_morphology0.94959417
117MP0002111_abnormal_tail_morphology0.94814211
118MP0000762_abnormal_tongue_morphology0.94458440
119MP0003123_paternal_imprinting0.94090447
120MP0003634_abnormal_glial_cell0.93794158
121MP0004043_abnormal_pH_regulation0.93564532
122MP0006072_abnormal_retinal_apoptosis0.91376889
123MP0005391_vision/eye_phenotype0.90249697
124MP0005503_abnormal_tendon_morphology0.89377972
125MP0003938_abnormal_ear_development0.89351698
126MP0008057_abnormal_DNA_replication0.89237969
127MP0008872_abnormal_physiological_respon0.88364342
128MP0005171_absent_coat_pigmentation0.87702713
129MP0004036_abnormal_muscle_relaxation0.87050268
130MP0002160_abnormal_reproductive_system0.86826755
131MP0002752_abnormal_somatic_nervous0.86540786
132MP0002069_abnormal_eating/drinking_beha0.85926649
133MP0001346_abnormal_lacrimal_gland0.85580235
134MP0009053_abnormal_anal_canal0.84781695
135MP0009672_abnormal_birth_weight0.84261659
136MP0000432_abnormal_head_morphology0.83385463
137MP0000920_abnormal_myelination0.82869135
138MP0008874_decreased_physiological_sensi0.82112636
139MP0000647_abnormal_sebaceous_gland0.81883278
140MP0001672_abnormal_embryogenesis/_devel0.81821674
141MP0005380_embryogenesis_phenotype0.81821674
142MP0000631_abnormal_neuroendocrine_gland0.81503844
143MP0005535_abnormal_body_temperature0.81308435
144MP0000516_abnormal_urinary_system0.80787647
145MP0005367_renal/urinary_system_phenotyp0.80787647
146MP0004147_increased_porphyrin_level0.80686877
147MP0003632_abnormal_nervous_system0.80463275
148MP0003690_abnormal_glial_cell0.79545565
149MP0001697_abnormal_embryo_size0.78755315
150MP0001177_atelectasis0.78125051
151MP0000579_abnormal_nail_morphology0.78095269
152MP0002116_abnormal_craniofacial_bone0.77789669
153MP0005253_abnormal_eye_physiology0.77507985
154MP0004484_altered_response_of0.73434263
155MP0001986_abnormal_taste_sensitivity0.71674452
156MP0001299_abnormal_eye_distance/0.70978703
157MP0005499_abnormal_olfactory_system0.67595606
158MP0005394_taste/olfaction_phenotype0.67595606
159MP0001664_abnormal_digestion0.67542091
160MP0005623_abnormal_meninges_morphology0.66771280
161MP0000604_amyloidosis0.66253396
162MP0003172_abnormal_lysosome_physiology0.65183285
163MP0001943_abnormal_respiration0.59441953
164MP0003137_abnormal_impulse_conducting0.58779248
165MP0001485_abnormal_pinna_reflex0.58300533
166MP0000026_abnormal_inner_ear0.57756163
167MP0003646_muscle_fatigue0.57044343
168MP0004084_abnormal_cardiac_muscle0.51666936
169MP0002332_abnormal_exercise_endurance0.51464080

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.10500540
2Atonic seizures (HP:0010819)5.89676009
3Epileptic encephalopathy (HP:0200134)5.72680129
4Myokymia (HP:0002411)5.58892989
5Focal seizures (HP:0007359)5.43202126
6Febrile seizures (HP:0002373)5.29610649
7Visual hallucinations (HP:0002367)4.75099851
8Absence seizures (HP:0002121)4.69413738
9Progressive cerebellar ataxia (HP:0002073)4.45567610
10Dialeptic seizures (HP:0011146)4.27320605
11Hyperventilation (HP:0002883)3.79237905
12Generalized tonic-clonic seizures (HP:0002069)3.79034287
13Gaze-evoked nystagmus (HP:0000640)3.56300345
14Colon cancer (HP:0003003)3.47936187
15Action tremor (HP:0002345)3.37434699
16Abnormality of the labia minora (HP:0012880)3.37287556
17Broad-based gait (HP:0002136)3.26769422
18Pheochromocytoma (HP:0002666)3.22336687
19Truncal ataxia (HP:0002078)3.12370056
20Septo-optic dysplasia (HP:0100842)3.10639761
21Dysdiadochokinesis (HP:0002075)3.03130932
22Neuroendocrine neoplasm (HP:0100634)2.95775327
23Abnormal eating behavior (HP:0100738)2.95083448
24Depression (HP:0000716)2.89643282
25Scanning speech (HP:0002168)2.86664854
26Abnormal lung lobation (HP:0002101)2.84307969
27Dysmetria (HP:0001310)2.76391340
28Anxiety (HP:0000739)2.75116369
29Epileptiform EEG discharges (HP:0011182)2.70780149
30Impaired vibration sensation in the lower limbs (HP:0002166)2.70124285
31Supranuclear gaze palsy (HP:0000605)2.66376055
32Poor eye contact (HP:0000817)2.66058928
33Gait imbalance (HP:0002141)2.63501968
34Diplopia (HP:0000651)2.63107886
35Abnormality of binocular vision (HP:0011514)2.63107886
36Ankle clonus (HP:0011448)2.61056528
37True hermaphroditism (HP:0010459)2.58815560
38Bifid tongue (HP:0010297)2.55382713
39EEG with generalized epileptiform discharges (HP:0011198)2.49437486
40Hemiparesis (HP:0001269)2.49299344
41Abnormal social behavior (HP:0012433)2.44982035
42Impaired social interactions (HP:0000735)2.44982035
43Congenital primary aphakia (HP:0007707)2.43618148
44Impaired smooth pursuit (HP:0007772)2.42676224
45Abnormal hair whorl (HP:0010721)2.37713910
46Dysmetric saccades (HP:0000641)2.37451733
47Amblyopia (HP:0000646)2.36629349
48Urinary bladder sphincter dysfunction (HP:0002839)2.35619771
49Medial flaring of the eyebrow (HP:0010747)2.34208202
50Polyphagia (HP:0002591)2.33916723
51Hyperglycinemia (HP:0002154)2.33129012
52Genetic anticipation (HP:0003743)2.32002464
53Nephrogenic diabetes insipidus (HP:0009806)2.29462667
54Excessive salivation (HP:0003781)2.29026776
55Drooling (HP:0002307)2.29026776
56Hypsarrhythmia (HP:0002521)2.27783642
57Hemiplegia (HP:0002301)2.26024585
58Progressive inability to walk (HP:0002505)2.24518991
59Acute encephalopathy (HP:0006846)2.22568779
60Spastic gait (HP:0002064)2.21507276
61Absent speech (HP:0001344)2.19866093
62Abnormal mitochondria in muscle tissue (HP:0008316)2.19648452
63Central scotoma (HP:0000603)2.17163279
64Intestinal atresia (HP:0011100)2.17103367
65Abnormality of ocular smooth pursuit (HP:0000617)2.17081499
66Embryonal renal neoplasm (HP:0011794)2.16051990
67Postural instability (HP:0002172)2.15485560
68Medulloblastoma (HP:0002885)2.15327168
69Stenosis of the external auditory canal (HP:0000402)2.14987631
70Anophthalmia (HP:0000528)2.14941985
71Meckel diverticulum (HP:0002245)2.14296102
72Congenital stationary night blindness (HP:0007642)2.13983454
73Pancreatic fibrosis (HP:0100732)2.13863721
74Status epilepticus (HP:0002133)2.13756444
75Bradykinesia (HP:0002067)2.13387923
76Absent septum pellucidum (HP:0001331)2.13169791
77Failure to thrive in infancy (HP:0001531)2.11419724
78Esophageal atresia (HP:0002032)2.10897276
79Acute necrotizing encephalopathy (HP:0006965)2.10695028
80Increased hepatocellular lipid droplets (HP:0006565)2.09933670
81Generalized myoclonic seizures (HP:0002123)2.09155186
82Supernumerary spleens (HP:0009799)2.09040373
83Abnormality of the lower motor neuron (HP:0002366)2.08403929
84Short tibia (HP:0005736)2.08254538
85Limb dystonia (HP:0002451)2.07233811
86Resting tremor (HP:0002322)2.06634189
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.06532616
88Nephroblastoma (Wilms tumor) (HP:0002667)2.05563369
89Torticollis (HP:0000473)2.04688548
90Neoplasm of the peripheral nervous system (HP:0100007)2.04510048
91Volvulus (HP:0002580)2.04452615
92Narrow nasal bridge (HP:0000446)2.03210562
93Hypoventilation (HP:0002791)2.01754177
94Gait ataxia (HP:0002066)2.01733917
95Fetal akinesia sequence (HP:0001989)2.01646936
96Triphalangeal thumb (HP:0001199)2.01442670
97Abnormality of the ileum (HP:0001549)2.01232772
98Focal dystonia (HP:0004373)2.01049889
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00734728
100Optic nerve hypoplasia (HP:0000609)2.00342532
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.99943863
102Urinary urgency (HP:0000012)1.97850285
103Retinal dysplasia (HP:0007973)1.97411412
104Postural tremor (HP:0002174)1.97237824
105Gastrointestinal atresia (HP:0002589)1.96806323
106Blue irides (HP:0000635)1.96789727
107Mutism (HP:0002300)1.96782476
108Progressive macrocephaly (HP:0004481)1.96769593
109Termporal pattern (HP:0011008)1.96391721
110Insidious onset (HP:0003587)1.96391721
111Specific learning disability (HP:0001328)1.96124388
112Inability to walk (HP:0002540)1.95965936
113Spinal canal stenosis (HP:0003416)1.95922253
114Abnormality of macular pigmentation (HP:0008002)1.94931940
115Methylmalonic acidemia (HP:0002912)1.94805619
116Agitation (HP:0000713)1.93539258
117Coronal craniosynostosis (HP:0004440)1.92379245
118Impaired vibratory sensation (HP:0002495)1.91773439
119Vaginal atresia (HP:0000148)1.91517913
120Nephronophthisis (HP:0000090)1.90401068
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90235584
122Genital tract atresia (HP:0001827)1.90192125
123Broad foot (HP:0001769)1.89642687
124Protruding tongue (HP:0010808)1.89298126
125Preaxial foot polydactyly (HP:0001841)1.89123081
126Intention tremor (HP:0002080)1.88622627
127Glioma (HP:0009733)1.87184371
128Poor suck (HP:0002033)1.86934524
129Chromsome breakage (HP:0040012)1.86593979
130Stereotypic behavior (HP:0000733)1.85373081
131Abnormality of serum amino acid levels (HP:0003112)1.85260887
132Cortical dysplasia (HP:0002539)1.84817851
133Neoplasm of the oral cavity (HP:0100649)1.84553890
134Craniofacial dystonia (HP:0012179)1.83533512
135Ependymoma (HP:0002888)1.83087765
136Limb ataxia (HP:0002070)1.82182659
137Abnormality of midbrain morphology (HP:0002418)1.81770694
138Molar tooth sign on MRI (HP:0002419)1.81770694
139Abnormality of saccadic eye movements (HP:0000570)1.81058703
140Lipid accumulation in hepatocytes (HP:0006561)1.80664070
141Abnormality of the corticospinal tract (HP:0002492)1.80642761
142Incomplete penetrance (HP:0003829)1.79968778
143Abnormality of chromosome stability (HP:0003220)1.79329437
144Bilateral microphthalmos (HP:0007633)1.78305620
145Lower limb muscle weakness (HP:0007340)1.77459213
146Gonadotropin excess (HP:0000837)1.76582389
147Cutaneous finger syndactyly (HP:0010554)1.76565302
148Abnormality of the septum pellucidum (HP:0007375)1.76005890
149Hemivertebrae (HP:0002937)1.75959842
150Mitochondrial inheritance (HP:0001427)1.75508730
151Psychosis (HP:0000709)1.74922369
152Preaxial hand polydactyly (HP:0001177)1.74894809
153Hepatoblastoma (HP:0002884)1.74265860
154Cerebral edema (HP:0002181)1.74257300
155Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73445075
156Increased CSF lactate (HP:0002490)1.72346600
157Abnormality of the duodenum (HP:0002246)1.72258317
158Pancreatic cysts (HP:0001737)1.71922241
159Postaxial hand polydactyly (HP:0001162)1.70262719
160Renal hypoplasia (HP:0000089)1.70172426
161Aplasia/Hypoplasia of the tongue (HP:0010295)1.66855003
162Hypoplastic pelvis (HP:0008839)1.66468012
163Duodenal stenosis (HP:0100867)1.65423039
164Small intestinal stenosis (HP:0012848)1.65423039
165Abnormality of methionine metabolism (HP:0010901)1.63512983
166Myelomeningocele (HP:0002475)1.62116428
167Maternal diabetes (HP:0009800)1.62038208
168Abnormal number of incisors (HP:0011064)1.61630608
169Anencephaly (HP:0002323)1.60077761
170Median cleft lip (HP:0000161)1.59940091
171Dandy-Walker malformation (HP:0001305)1.59891549
172Postaxial foot polydactyly (HP:0001830)1.59746333
173Sclerocornea (HP:0000647)1.59634301
174Cutaneous syndactyly (HP:0012725)1.59214463
175Ectopic kidney (HP:0000086)1.56875771
176Small hand (HP:0200055)1.56384363
177Absent radius (HP:0003974)1.55053319
178Abnormality of the astrocytes (HP:0100707)1.54975358
179Astrocytoma (HP:0009592)1.54975358
180Postnatal microcephaly (HP:0005484)1.54521287
181Aplasia/Hypoplasia of the sternum (HP:0006714)1.53800322
182Occipital encephalocele (HP:0002085)1.52739230
183Pancreatic islet-cell hyperplasia (HP:0004510)1.50188461
184Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.49738504
185Abnormality of glycine metabolism (HP:0010895)1.48957039
186Abnormality of serine family amino acid metabolism (HP:0010894)1.48957039
187Aplasia involving forearm bones (HP:0009822)1.48938739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.47816201
2NTRK34.26311104
3EPHA43.44790121
4PBK3.27797861
5MAP3K43.22636492
6MAP2K72.95916968
7BUB12.85933238
8MAP3K122.69470009
9WEE12.67909572
10MAP3K92.62245237
11TTK2.60062095
12MINK12.53962510
13MKNK12.51866282
14PLK42.37297821
15MKNK22.36385798
16SRPK12.33245418
17CDK192.31771402
18CDC72.29698770
19PLK32.25610850
20DAPK22.13686562
21MAP2K42.13631395
22ZAK2.05880278
23VRK21.98937640
24PLK21.96343310
25ARAF1.90650694
26MARK11.83957417
27BRSK21.83245679
28BMPR1B1.78528371
29PRPF4B1.78011131
30PAK61.65441323
31DAPK11.64951201
32TAF11.63542637
33NTRK21.62944132
34OXSR11.62679942
35VRK11.55399352
36TRIM281.54652868
37CAMKK21.53635896
38NUAK11.51257418
39PRKD31.46473941
40AKT31.44160737
41PLK11.39616148
42NTRK11.38013963
43STK161.35566796
44CAMKK11.35385251
45GRK51.35127219
46FES1.34500693
47CDK51.33736165
48PRKCG1.31713936
49EPHB21.31508243
50SGK2231.26811188
51SGK4941.26811188
52KSR21.25625228
53MAPK131.25161190
54RIPK41.24400376
55STK38L1.19337179
56DYRK21.19042825
57CCNB11.16849049
58TNIK1.16746178
59CAMK2A1.14864806
60FGFR21.10605017
61MAP4K21.10560978
62CSNK1G11.10283301
63PHKG11.10213644
64PHKG21.10213644
65SGK21.08755995
66DYRK31.05899493
67KSR11.05374655
68CAMK2B1.03018297
69ERBB31.02130596
70STK381.01394201
71MST40.99619590
72PASK0.98507817
73TGFBR10.95735418
74BRSK10.95253942
75EIF2AK30.95010703
76EIF2AK10.94759535
77CDK140.92934591
78CDK180.92408696
79TIE10.91061846
80PDK40.90809059
81PDK30.90809059
82LATS10.90281216
83NEK20.89897026
84UHMK10.89679544
85MAP3K130.88614525
86CDK150.88078234
87PRKCE0.85858369
88BRAF0.85414266
89CHEK20.85054423
90CSNK1G30.83516650
91TSSK60.83355462
92PNCK0.83341319
93ERBB40.83187550
94CAMK2D0.82503091
95FGFR10.82431334
96NEK10.78374338
97WNK10.77782390
98NME10.77207929
99PRKCH0.77172968
100MAP3K20.77147765
101PTK2B0.76965713
102ATR0.76684184
103BCKDK0.76100827
104CAMK10.75807840
105STK30.74088666
106CDK11A0.73896698
107LMTK20.73221815
108FER0.73123351
109CSNK1A1L0.71866768
110CAMK2G0.71330830
111AURKB0.71032853
112BMPR20.70706126
113SGK30.67570512
114TAOK10.67092944
115CDK30.65953501
116ACVR1B0.65149703
117LATS20.64211708
118PINK10.61784403
119SIK30.61668588
120SGK10.61279877
121FRK0.61180533
122TNK20.60986350
123EIF2AK20.60867986
124ATM0.59972335
125STK390.59698912
126RET0.59463611
127GRK10.58131682
128PAK30.58089056
129NEK60.57901271
130LIMK10.56966558
131DYRK1A0.55366972
132CSNK1G20.54180725
133MAP3K10.53894370
134MAPKAPK50.53568889
135PDK10.52787592
136PDPK10.52667803
137MYLK0.51862875
138ADRBK20.50177407
139ADRBK10.50143869
140BCR0.49764705
141FLT30.49119037
142CSNK1E0.47554029
143RPS6KA40.47228471
144STK110.46859576
145DAPK30.46285915
146MUSK0.45761542
147ROCK20.45675735
148CHEK10.45380288
149PRKDC0.44851276
150RAF10.44302539
151GRK70.42923255
152WNK30.42904739
153PDK20.42776930
154RPS6KA30.42431318
155INSRR0.40628009
156SIK20.39776894
157MARK20.39586356
158TYRO30.39155408
159MAP2K10.38931174
160PRKACA0.38554951
161CDK10.36948639
162CSNK2A10.36677592

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.23220363
2Synaptic vesicle cycle_Homo sapiens_hsa047213.89927683
3GABAergic synapse_Homo sapiens_hsa047272.96796938
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92901986
5Mismatch repair_Homo sapiens_hsa034302.69925528
6Morphine addiction_Homo sapiens_hsa050322.67805739
7Protein export_Homo sapiens_hsa030602.66041494
8Circadian entrainment_Homo sapiens_hsa047132.63697884
9Collecting duct acid secretion_Homo sapiens_hsa049662.60715203
10Proteasome_Homo sapiens_hsa030502.56714533
11Olfactory transduction_Homo sapiens_hsa047402.51822648
12Non-homologous end-joining_Homo sapiens_hsa034502.43285971
13Long-term potentiation_Homo sapiens_hsa047202.42579574
14Glutamatergic synapse_Homo sapiens_hsa047242.41287310
15DNA replication_Homo sapiens_hsa030302.31190655
16Amphetamine addiction_Homo sapiens_hsa050312.30085407
17Homologous recombination_Homo sapiens_hsa034402.13295842
18Dopaminergic synapse_Homo sapiens_hsa047282.11701810
19Fanconi anemia pathway_Homo sapiens_hsa034602.08331597
20RNA polymerase_Homo sapiens_hsa030202.07386326
21Taste transduction_Homo sapiens_hsa047422.05365126
22Propanoate metabolism_Homo sapiens_hsa006402.04099964
23Ribosome_Homo sapiens_hsa030102.02633391
24Insulin secretion_Homo sapiens_hsa049112.02229657
25Salivary secretion_Homo sapiens_hsa049701.96251192
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96034112
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93233263
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90056931
29Spliceosome_Homo sapiens_hsa030401.82977365
30Vibrio cholerae infection_Homo sapiens_hsa051101.80626671
31RNA transport_Homo sapiens_hsa030131.79321449
32Basal cell carcinoma_Homo sapiens_hsa052171.76939193
33Steroid biosynthesis_Homo sapiens_hsa001001.76483033
34Cholinergic synapse_Homo sapiens_hsa047251.71291817
35RNA degradation_Homo sapiens_hsa030181.69989857
36Long-term depression_Homo sapiens_hsa047301.69861290
37Serotonergic synapse_Homo sapiens_hsa047261.69113022
38Renin secretion_Homo sapiens_hsa049241.65631544
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61686403
40Gastric acid secretion_Homo sapiens_hsa049711.61514580
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58306708
42Basal transcription factors_Homo sapiens_hsa030221.57838216
43Nucleotide excision repair_Homo sapiens_hsa034201.56293646
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55776953
45Cell cycle_Homo sapiens_hsa041101.54770281
46Calcium signaling pathway_Homo sapiens_hsa040201.54038209
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.54026536
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53428818
49Cocaine addiction_Homo sapiens_hsa050301.52822928
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49885452
51Oxytocin signaling pathway_Homo sapiens_hsa049211.43904753
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43829142
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41672284
54Hedgehog signaling pathway_Homo sapiens_hsa043401.41514960
55Base excision repair_Homo sapiens_hsa034101.40395636
56Oxidative phosphorylation_Homo sapiens_hsa001901.38006351
57Phototransduction_Homo sapiens_hsa047441.37834259
58Cardiac muscle contraction_Homo sapiens_hsa042601.30113128
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26777341
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24378213
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20592686
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19958921
63Selenocompound metabolism_Homo sapiens_hsa004501.18319069
64One carbon pool by folate_Homo sapiens_hsa006701.16943859
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15355469
66Fatty acid elongation_Homo sapiens_hsa000621.14249325
67Gap junction_Homo sapiens_hsa045401.14218981
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13766745
69cAMP signaling pathway_Homo sapiens_hsa040241.12293396
70Hippo signaling pathway_Homo sapiens_hsa043901.09403418
71GnRH signaling pathway_Homo sapiens_hsa049121.09038840
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02421855
73Alzheimers disease_Homo sapiens_hsa050101.02241133
74Pyrimidine metabolism_Homo sapiens_hsa002400.99586628
75Vitamin B6 metabolism_Homo sapiens_hsa007500.99545077
76Type II diabetes mellitus_Homo sapiens_hsa049300.99389328
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99330896
78mRNA surveillance pathway_Homo sapiens_hsa030150.96537503
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95701471
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95236805
81Purine metabolism_Homo sapiens_hsa002300.95082944
82Parkinsons disease_Homo sapiens_hsa050120.94400643
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91609586
84Biosynthesis of amino acids_Homo sapiens_hsa012300.89502302
85TGF-beta signaling pathway_Homo sapiens_hsa043500.87773317
86Estrogen signaling pathway_Homo sapiens_hsa049150.86577048
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.84524354
88Glutathione metabolism_Homo sapiens_hsa004800.84163383
89Dilated cardiomyopathy_Homo sapiens_hsa054140.82776084
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82168079
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79572149
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79136787
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78252266
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74691139
95Axon guidance_Homo sapiens_hsa043600.74505837
96Folate biosynthesis_Homo sapiens_hsa007900.74095959
97Peroxisome_Homo sapiens_hsa041460.73619606
98* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73332563
99Carbon metabolism_Homo sapiens_hsa012000.73124142
100Pancreatic secretion_Homo sapiens_hsa049720.73042116
101ErbB signaling pathway_Homo sapiens_hsa040120.72517977
102Melanogenesis_Homo sapiens_hsa049160.72344089
103Thyroid hormone synthesis_Homo sapiens_hsa049180.71712005
104Rheumatoid arthritis_Homo sapiens_hsa053230.71373360
105p53 signaling pathway_Homo sapiens_hsa041150.70660656
106Glioma_Homo sapiens_hsa052140.69476940
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68338893
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68214796
109Nitrogen metabolism_Homo sapiens_hsa009100.67778747
110N-Glycan biosynthesis_Homo sapiens_hsa005100.65236004
111Type I diabetes mellitus_Homo sapiens_hsa049400.63594084
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62213459
113Oocyte meiosis_Homo sapiens_hsa041140.61676343
114* Metabolic pathways_Homo sapiens_hsa011000.60805119
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60736966
116Glucagon signaling pathway_Homo sapiens_hsa049220.59087959
117Circadian rhythm_Homo sapiens_hsa047100.56063181
118MAPK signaling pathway_Homo sapiens_hsa040100.55980623
119Fatty acid metabolism_Homo sapiens_hsa012120.55765903
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54747122
121Huntingtons disease_Homo sapiens_hsa050160.54649267
122Phagosome_Homo sapiens_hsa041450.53526000
123beta-Alanine metabolism_Homo sapiens_hsa004100.51780810
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51182799
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50569620
126Sulfur relay system_Homo sapiens_hsa041220.48569742
127Arginine and proline metabolism_Homo sapiens_hsa003300.47659351
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.47593319
129Tight junction_Homo sapiens_hsa045300.46295130
130Retinol metabolism_Homo sapiens_hsa008300.45848574
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45813861
132Pyruvate metabolism_Homo sapiens_hsa006200.45336111
133ECM-receptor interaction_Homo sapiens_hsa045120.44430381
134Alcoholism_Homo sapiens_hsa050340.44281718
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43400764
136Inositol phosphate metabolism_Homo sapiens_hsa005620.41832695
137Ras signaling pathway_Homo sapiens_hsa040140.41348128
138Vitamin digestion and absorption_Homo sapiens_hsa049770.40788695
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.40230016
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39672857
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39008087
142Butanoate metabolism_Homo sapiens_hsa006500.38532270
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38412286
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37773610
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37755539
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37691353
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36548335
148Fatty acid degradation_Homo sapiens_hsa000710.36257508
149Adherens junction_Homo sapiens_hsa045200.35265576
150Choline metabolism in cancer_Homo sapiens_hsa052310.34680896
151Dorso-ventral axis formation_Homo sapiens_hsa043200.34279603
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33772038
153Rap1 signaling pathway_Homo sapiens_hsa040150.33113859
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.30969677
155Ovarian steroidogenesis_Homo sapiens_hsa049130.30602307
156Endocytosis_Homo sapiens_hsa041440.28338679
157Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28150288
158Neurotrophin signaling pathway_Homo sapiens_hsa047220.28117761
159Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27023075
160Insulin signaling pathway_Homo sapiens_hsa049100.25342587
161Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24943100
162Bile secretion_Homo sapiens_hsa049760.23193306
163Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23103701
164Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21663868
165Wnt signaling pathway_Homo sapiens_hsa043100.19699577
166Fructose and mannose metabolism_Homo sapiens_hsa000510.18825028

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