EXPH5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the synaptotagmin-like protein (Slp) family lacking a C2 domain. It contains an N-terminal synaptotagmin-like homology domain (SHD), and is a ras-related protein Rab-27B effector protein. This protein is thought to be involved in exosome secretion and intracellular vesicle trafficking. Reduced expression of this gene results in keratin filament defects. Mutations in this gene have been associated with some cases of epidermolysis bullosa, an inherited skin fragility disorder. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of sodium ion transport (GO:0010766)4.58705558
2presynaptic membrane assembly (GO:0097105)4.33074476
3cellular ketone body metabolic process (GO:0046950)4.25545854
4presynaptic membrane organization (GO:0097090)4.16371974
5regulation of action potential (GO:0098900)3.96316421
6desmosome organization (GO:0002934)3.92735064
7estrogen biosynthetic process (GO:0006703)3.92046372
8ketone body metabolic process (GO:1902224)3.87398686
9negative regulation of hormone biosynthetic process (GO:0032353)3.83972059
10response to pheromone (GO:0019236)3.72005647
11neuron cell-cell adhesion (GO:0007158)3.71410157
12establishment of skin barrier (GO:0061436)3.65705234
13keratinization (GO:0031424)3.64439734
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59240792
15prostate gland growth (GO:0060736)3.57507111
16otic vesicle formation (GO:0030916)3.56374994
17neuronal action potential propagation (GO:0019227)3.52079233
18regulation of heart rate by cardiac conduction (GO:0086091)3.49771907
19central nervous system myelination (GO:0022010)3.49357024
20axon ensheathment in central nervous system (GO:0032291)3.49357024
21postsynaptic membrane organization (GO:0001941)3.48678758
22nephron tubule morphogenesis (GO:0072078)3.42256336
23nephron epithelium morphogenesis (GO:0072088)3.42256336
24vocalization behavior (GO:0071625)3.41042189
25axoneme assembly (GO:0035082)3.32308554
26regulation of glucokinase activity (GO:0033131)3.29975276
27regulation of hexokinase activity (GO:1903299)3.29975276
28water-soluble vitamin biosynthetic process (GO:0042364)3.28272517
29negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.24690475
30L-fucose catabolic process (GO:0042355)3.21984257
31fucose catabolic process (GO:0019317)3.21984257
32L-fucose metabolic process (GO:0042354)3.21984257
33negative regulation of hormone metabolic process (GO:0032351)3.21445963
34establishment of protein localization to Golgi (GO:0072600)3.19041420
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.17538149
36respiratory chain complex IV assembly (GO:0008535)3.15049339
37glutamate receptor signaling pathway (GO:0007215)3.12426331
38intestinal epithelial cell development (GO:0060576)3.11908450
39transmission of nerve impulse (GO:0019226)3.11614585
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10358076
41cerebellar granule cell differentiation (GO:0021707)3.10335591
42bundle of His cell to Purkinje myocyte communication (GO:0086069)3.09081663
43magnesium ion transport (GO:0015693)3.08992707
44G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07317576
45phospholipid homeostasis (GO:0055091)3.02460833
46long-chain fatty acid biosynthetic process (GO:0042759)3.01533604
47regulation of timing of cell differentiation (GO:0048505)3.00410790
48relaxation of cardiac muscle (GO:0055119)2.98915982
49startle response (GO:0001964)2.98863055
50gamma-aminobutyric acid signaling pathway (GO:0007214)2.98760028
51phospholipid efflux (GO:0033700)2.97778554
52protein K11-linked deubiquitination (GO:0035871)2.96472981
53regulation of cell communication by electrical coupling (GO:0010649)2.94943520
54estrogen metabolic process (GO:0008210)2.92612609
55righting reflex (GO:0060013)2.88289205
56regulation of water loss via skin (GO:0033561)2.88109961
57lactate metabolic process (GO:0006089)2.86040437
58cardiac conduction (GO:0061337)2.85733535
59reverse cholesterol transport (GO:0043691)2.84469117
60limb bud formation (GO:0060174)2.83888652
61positive regulation of synapse assembly (GO:0051965)2.82908561
62* keratinocyte development (GO:0003334)2.82338934
63protein targeting to Golgi (GO:0000042)2.82309290
64glandular epithelial cell differentiation (GO:0002067)2.82247466
65platelet dense granule organization (GO:0060155)2.81470977
66cardiac right ventricle morphogenesis (GO:0003215)2.81143416
67opioid receptor signaling pathway (GO:0038003)2.80554521
68cilium or flagellum-dependent cell motility (GO:0001539)2.79847534
69nucleotide transmembrane transport (GO:1901679)2.77636640
70indolalkylamine metabolic process (GO:0006586)2.77621699
71positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77525764
72renal tubule morphogenesis (GO:0061333)2.75483706
73indole-containing compound catabolic process (GO:0042436)2.73996903
74indolalkylamine catabolic process (GO:0046218)2.73996903
75tryptophan catabolic process (GO:0006569)2.73996903
76positive regulation of glycolytic process (GO:0045821)2.73383013
77fatty acid elongation (GO:0030497)2.72134236
78reflex (GO:0060004)2.71302804
79preassembly of GPI anchor in ER membrane (GO:0016254)2.69306120
80synaptic transmission, glutamatergic (GO:0035249)2.68954608
81protein localization to Golgi apparatus (GO:0034067)2.67601299
82kidney morphogenesis (GO:0060993)2.67498159
83negative regulation of neurotransmitter transport (GO:0051589)2.66065783
84inner ear receptor cell development (GO:0060119)2.65230827
85high-density lipoprotein particle remodeling (GO:0034375)2.64801359
86neuron-neuron synaptic transmission (GO:0007270)2.64791901
87regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64032173
88detection of calcium ion (GO:0005513)2.62848054
89positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.61002056
90neuron remodeling (GO:0016322)2.60901190
91sphingoid metabolic process (GO:0046519)2.60376082
92signal transduction involved in regulation of gene expression (GO:0023019)2.60097158
93retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57589992
94regulation of hippo signaling (GO:0035330)2.57553851
95gamma-aminobutyric acid transport (GO:0015812)2.55955336
96cytochrome complex assembly (GO:0017004)2.55336068
97calcium ion import (GO:0070509)2.54964587
98regulation of type B pancreatic cell apoptotic process (GO:2000674)2.54619511
99regulation of sodium ion transmembrane transporter activity (GO:2000649)2.54224991
100thyroid hormone metabolic process (GO:0042403)2.53808422
101protein localization to cilium (GO:0061512)2.53384659
102somite rostral/caudal axis specification (GO:0032525)2.52800936
103negative regulation of neurotransmitter secretion (GO:0046929)2.52458387
104L-amino acid import (GO:0043092)2.51920585
105tryptophan metabolic process (GO:0006568)2.50570961
106mechanosensory behavior (GO:0007638)2.50216454
107axonemal dynein complex assembly (GO:0070286)2.50101421
108insulin secretion (GO:0030073)2.49919305
109cerebral cortex radially oriented cell migration (GO:0021799)2.49082048
110endocrine pancreas development (GO:0031018)2.47980246
111positive regulation of protein autophosphorylation (GO:0031954)2.47234123
112regulation of synapse assembly (GO:0051963)2.46773080
113prenylation (GO:0097354)2.46634212
114protein prenylation (GO:0018342)2.46634212
115photoreceptor cell maintenance (GO:0045494)2.46540819
116polyol transport (GO:0015791)2.45669755
117detection of light stimulus involved in visual perception (GO:0050908)2.45309883
118detection of light stimulus involved in sensory perception (GO:0050962)2.45309883
119regulation of mesoderm development (GO:2000380)2.44362110
120behavioral response to nicotine (GO:0035095)2.44306609
121positive regulation of action potential (GO:0045760)2.43926888
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43745090
123regulation of protein glycosylation (GO:0060049)2.43708920
124protein polyglutamylation (GO:0018095)2.42668888
125intraciliary transport (GO:0042073)2.42620351
126positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.41468573
127forebrain morphogenesis (GO:0048853)2.41210778
128hindbrain development (GO:0030902)2.41171124
129polyol catabolic process (GO:0046174)2.39645895
130regulation of development, heterochronic (GO:0040034)2.39610329
131import into cell (GO:0098657)2.39441483
132positive regulation of muscle hypertrophy (GO:0014742)2.38983434
133positive regulation of cardiac muscle hypertrophy (GO:0010613)2.38983434
134cerebellar Purkinje cell differentiation (GO:0021702)2.38820691
135positive regulation of glycoprotein biosynthetic process (GO:0010560)2.38754487
136dopamine biosynthetic process (GO:0042416)2.38737420
137DNA deamination (GO:0045006)2.38163818
138cornea development in camera-type eye (GO:0061303)2.38145957
139auditory behavior (GO:0031223)2.38024423
140cell differentiation in hindbrain (GO:0021533)2.37229211
141kynurenine metabolic process (GO:0070189)2.37201276
142retina layer formation (GO:0010842)2.36543828
143polarized epithelial cell differentiation (GO:0030859)2.36456560
144negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.36366478
145chemosensory behavior (GO:0007635)2.36263674
146cranial nerve development (GO:0021545)2.35114233
147negative regulation of keratinocyte proliferation (GO:0010839)2.33835636
148glycerophospholipid catabolic process (GO:0046475)2.31511658
149regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.31227772
150neuron recognition (GO:0008038)2.30488791
151regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29438356
152positive regulation of cellular amine metabolic process (GO:0033240)2.25468219
153dendritic spine morphogenesis (GO:0060997)2.25064888
154epithelial cilium movement (GO:0003351)2.24771443
155mesenchymal cell differentiation involved in kidney development (GO:0072161)2.22951818
156mesenchymal cell differentiation involved in renal system development (GO:2001012)2.22951818
157synapse assembly (GO:0007416)2.22743362
158regulation of phospholipase A2 activity (GO:0032429)2.21622352
159protein localization to synapse (GO:0035418)2.20899192
160cilium movement (GO:0003341)2.20661073
161eye photoreceptor cell differentiation (GO:0001754)2.20467817
162photoreceptor cell differentiation (GO:0046530)2.20467817
163regulation of postsynaptic membrane potential (GO:0060078)2.19964508
164auditory receptor cell stereocilium organization (GO:0060088)2.16817019
165regulation of respiratory system process (GO:0044065)2.16370947
166response to redox state (GO:0051775)2.15420561
167inner ear receptor stereocilium organization (GO:0060122)2.15200577
168superoxide anion generation (GO:0042554)2.14334902
169regulation of short-term neuronal synaptic plasticity (GO:0048172)2.14152396
170parturition (GO:0007567)2.13699767
171long-term memory (GO:0007616)2.12631980
172regulation of vesicle fusion (GO:0031338)2.11547392
173cochlea development (GO:0090102)2.11533973
174detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.11122641
175positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.11107752
176negative regulation of protein localization to cell surface (GO:2000009)2.10539899
177regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.10426415
178purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.09588058
1793-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.09588058
180cellular copper ion homeostasis (GO:0006878)2.07541323
181regulation of feeding behavior (GO:0060259)2.06537531
182neurotransmitter-gated ion channel clustering (GO:0072578)2.04843023
183GPI anchor metabolic process (GO:0006505)2.04724461
184regulation of respiratory gaseous exchange (GO:0043576)2.04370566
185adult walking behavior (GO:0007628)2.04346234
186regulation of glutamate receptor signaling pathway (GO:1900449)2.03382033
187adult behavior (GO:0030534)2.03100040
188pyrimidine-containing compound transmembrane transport (GO:0072531)2.02203573
189long-term synaptic potentiation (GO:0060291)2.02195445
190multicellular organismal signaling (GO:0035637)2.02046953
191neurotransmitter transport (GO:0006836)2.01902627
192cAMP-mediated signaling (GO:0019933)2.01890623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.66503255
2GBX2_23144817_ChIP-Seq_PC3_Human3.62926511
3ZNF274_21170338_ChIP-Seq_K562_Hela2.74821018
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45234067
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42571774
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41977828
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40508652
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37773689
9TAF15_26573619_Chip-Seq_HEK293_Human2.30359321
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.30061168
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25674316
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18574901
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16967559
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.14163374
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11814857
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06736463
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04499383
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98867767
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98731261
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98731261
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94394648
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89194554
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.87625209
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.86602707
25EWS_26573619_Chip-Seq_HEK293_Human1.83673162
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.83201691
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.83001192
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82872829
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77489992
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77096985
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76127670
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.75558894
33P300_19829295_ChIP-Seq_ESCs_Human1.75531843
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75029831
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72352495
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72352273
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71646153
38VDR_22108803_ChIP-Seq_LS180_Human1.70524804
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69700041
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66988712
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.66508518
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64923777
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.60550922
44* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58711403
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.57445401
46CDX2_22108803_ChIP-Seq_LS180_Human1.56966085
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.56156515
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53371444
49TCF4_22108803_ChIP-Seq_LS180_Human1.53030453
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52975430
51REST_21632747_ChIP-Seq_MESCs_Mouse1.51863267
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50746196
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47957533
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46842210
55CBP_20019798_ChIP-Seq_JUKART_Human1.46842210
56DROSHA_22980978_ChIP-Seq_HELA_Human1.46355551
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46193600
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.45789444
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.45587678
60AR_21572438_ChIP-Seq_LNCaP_Human1.45098542
61RNF2_27304074_Chip-Seq_NSC_Mouse1.41634821
62P53_22387025_ChIP-Seq_ESCs_Mouse1.41365615
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39886340
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38807358
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.37368919
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36308142
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35842713
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35731419
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34863219
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.34601998
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.33514617
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33018180
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32328505
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32159110
75NANOG_19829295_ChIP-Seq_ESCs_Human1.32064936
76SOX2_19829295_ChIP-Seq_ESCs_Human1.32064936
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31969335
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31437856
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30809185
80ER_23166858_ChIP-Seq_MCF-7_Human1.30498430
81IGF1R_20145208_ChIP-Seq_DFB_Human1.29880365
82P300_18555785_Chip-Seq_ESCs_Mouse1.28819405
83NMYC_18555785_Chip-Seq_ESCs_Mouse1.28359358
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27263416
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.27113666
86TP53_18474530_ChIP-ChIP_U2OS_Human1.26859784
87* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26492054
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.26408739
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26408739
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25813208
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25488462
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25388361
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.23936600
94* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23013118
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.22069876
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20400039
97STAT3_23295773_ChIP-Seq_U87_Human1.20323972
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20161893
99AR_25329375_ChIP-Seq_VCAP_Human1.19240793
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18135532
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.17867830
102RUNX2_22187159_ChIP-Seq_PCA_Human1.17729845
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17530857
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17222818
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.17130403
106TP53_16413492_ChIP-PET_HCT116_Human1.16982354
107RXR_22108803_ChIP-Seq_LS180_Human1.16395724
108KDM2B_26808549_Chip-Seq_REH_Human1.16130241
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16085471
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14677919
111PU1_27457419_Chip-Seq_LIVER_Mouse1.14642216
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.14581756
113AHR_22903824_ChIP-Seq_MCF-7_Human1.14104691
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.13998065
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13959198
116SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13495263
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12919074
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.12813063
119ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12467575
120TCF4_23295773_ChIP-Seq_U87_Human1.12127390
121FUS_26573619_Chip-Seq_HEK293_Human1.11546233
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10810928
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.10570191
124ZFX_18555785_Chip-Seq_ESCs_Mouse1.10405118
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.10097929
126GATA4_25053715_ChIP-Seq_YYC3_Human1.09712844
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09535596
128P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09204706
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07802331
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07213184
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06182715
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06182715
133CTCF_18555785_Chip-Seq_ESCs_Mouse1.06130695
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05816597
135NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05816597
136ESR1_20079471_ChIP-ChIP_T-47D_Human1.05195853
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.05104155
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04822549
139TP63_23658742_ChIP-Seq_EP156T_Human1.04795706
140* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03973727
141BCAT_22108803_ChIP-Seq_LS180_Human1.03343930
142* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03225727
143HTT_18923047_ChIP-ChIP_STHdh_Human1.02610314
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02169707

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.96851373
2MP0001188_hyperpigmentation2.88266817
3MP0000566_synostosis2.62138681
4MP0003136_yellow_coat_color2.60174232
5MP0008877_abnormal_DNA_methylation2.48535230
6MP0009046_muscle_twitch2.37713621
7MP0000427_abnormal_hair_cycle2.33816801
8MP0005423_abnormal_somatic_nervous2.33761481
9MP0005367_renal/urinary_system_phenotyp2.33357027
10MP0000516_abnormal_urinary_system2.33357027
11MP0004381_abnormal_hair_follicle2.33193811
12MP0001486_abnormal_startle_reflex2.31591587
13MP0004742_abnormal_vestibular_system2.21049922
14MP0005379_endocrine/exocrine_gland_phen2.21029329
15MP0009745_abnormal_behavioral_response2.18486262
16MP0004270_analgesia2.06591489
17MP0006292_abnormal_olfactory_placode2.04065644
18MP0002272_abnormal_nervous_system2.03606216
19MP0003635_abnormal_synaptic_transmissio1.97933079
20MP0000647_abnormal_sebaceous_gland1.92946468
21MP0005645_abnormal_hypothalamus_physiol1.90102081
22MP0001501_abnormal_sleep_pattern1.87414065
23MP0003890_abnormal_embryonic-extraembry1.86985205
24MP0002735_abnormal_chemical_nociception1.85958549
25MP0003195_calcinosis1.85397385
26MP0002572_abnormal_emotion/affect_behav1.85001708
27MP0002734_abnormal_mechanical_nocicepti1.84693039
28MP0005646_abnormal_pituitary_gland1.81974163
29MP0010234_abnormal_vibrissa_follicle1.81474930
30MP0001440_abnormal_grooming_behavior1.79925347
31MP0001968_abnormal_touch/_nociception1.76121711
32MP0002837_dystrophic_cardiac_calcinosis1.75318361
33MP0005409_darkened_coat_color1.73756967
34MP0002064_seizures1.73377914
35MP0001986_abnormal_taste_sensitivity1.72895239
36MP0002067_abnormal_sensory_capabilities1.72673881
37MP0000372_irregular_coat_pigmentation1.61734790
38MP0002557_abnormal_social/conspecific_i1.58898727
39MP0002138_abnormal_hepatobiliary_system1.58170603
40MP0010386_abnormal_urinary_bladder1.55651985
41MP0004859_abnormal_synaptic_plasticity1.55623345
42MP0008875_abnormal_xenobiotic_pharmacok1.55496191
43MP0006276_abnormal_autonomic_nervous1.54400170
44MP0002938_white_spotting1.54342716
45MP0010329_abnormal_lipoprotein_level1.53735458
46MP0002063_abnormal_learning/memory/cond1.52183349
47MP0001502_abnormal_circadian_rhythm1.52067759
48MP0002102_abnormal_ear_morphology1.48770589
49MP0002796_impaired_skin_barrier1.48649948
50MP0004142_abnormal_muscle_tone1.47512455
51MP0002876_abnormal_thyroid_physiology1.45790802
52MP0004264_abnormal_extraembryonic_tissu1.44579665
53MP0008057_abnormal_DNA_replication1.43230027
54MP0003191_abnormal_cellular_cholesterol1.42215361
55MP0005451_abnormal_body_composition1.41919497
56MP0008872_abnormal_physiological_respon1.41084967
57MP0009379_abnormal_foot_pigmentation1.40867984
58MP0001485_abnormal_pinna_reflex1.39830988
59MP0001984_abnormal_olfaction1.39740329
60MP0001963_abnormal_hearing_physiology1.39613319
61MP0004043_abnormal_pH_regulation1.39461479
62MP0002277_abnormal_respiratory_mucosa1.38966922
63MP0000026_abnormal_inner_ear1.38733044
64MP0002638_abnormal_pupillary_reflex1.37735714
65MP0000462_abnormal_digestive_system1.37284017
66MP0003879_abnormal_hair_cell1.36877619
67MP0000778_abnormal_nervous_system1.36634634
68MP0002160_abnormal_reproductive_system1.36170321
69MP0005171_absent_coat_pigmentation1.35294161
70MP0005551_abnormal_eye_electrophysiolog1.34760298
71MP0000383_abnormal_hair_follicle1.34499634
72MP0000569_abnormal_digit_pigmentation1.33976890
73MP0001905_abnormal_dopamine_level1.33746191
74MP0000579_abnormal_nail_morphology1.33201566
75MP0002736_abnormal_nociception_after1.32263332
76MP0003787_abnormal_imprinting1.30307574
77MP0008569_lethality_at_weaning1.28738235
78MP0002184_abnormal_innervation1.28404464
79MP0000537_abnormal_urethra_morphology1.26356626
80MP0005389_reproductive_system_phenotype1.25345819
81MP0002139_abnormal_hepatobiliary_system1.24251867
82MP0005085_abnormal_gallbladder_physiolo1.22403185
83MP0001346_abnormal_lacrimal_gland1.21627500
84MP0009697_abnormal_copulation1.20377926
85MP0004133_heterotaxia1.16827974
86MP0004147_increased_porphyrin_level1.16656352
87MP0001970_abnormal_pain_threshold1.16001147
88MP0009780_abnormal_chondrocyte_physiolo1.15617607
89MP0003941_abnormal_skin_development1.15325881
90MP0001919_abnormal_reproductive_system1.13557718
91MP0003283_abnormal_digestive_organ1.12172551
92MP0005636_abnormal_mineral_homeostasis1.12148961
93MP0000631_abnormal_neuroendocrine_gland1.11415929
94MP0001756_abnormal_urination1.11183992
95MP0003011_delayed_dark_adaptation1.10633216
96MP0000613_abnormal_salivary_gland1.10375492
97MP0000920_abnormal_myelination1.09123779
98MP0005365_abnormal_bile_salt1.07891000
99MP0005084_abnormal_gallbladder_morpholo1.05772621
100MP0004885_abnormal_endolymph1.05658135
101MP0002254_reproductive_system_inflammat1.04678268
102MP0001944_abnormal_pancreas_morphology1.04134983
103MP0005174_abnormal_tail_pigmentation1.04023581
104MP0003950_abnormal_plasma_membrane1.03226030
105MP0005220_abnormal_exocrine_pancreas1.02832765
106MP0003718_maternal_effect1.01851227
107MP0002909_abnormal_adrenal_gland1.01197819
108MP0001664_abnormal_digestion1.00288610
109MP0006072_abnormal_retinal_apoptosis0.99958696
110MP0004019_abnormal_vitamin_homeostasis0.99825911
111MP0005083_abnormal_biliary_tract0.98524322
112MP0002098_abnormal_vibrissa_morphology0.98484387
113MP0003119_abnormal_digestive_system0.97940844
114MP0002733_abnormal_thermal_nociception0.97003843
115MP0005075_abnormal_melanosome_morpholog0.96498791
116MP0005377_hearing/vestibular/ear_phenot0.96186525
117MP0003878_abnormal_ear_physiology0.96186525
118MP0004215_abnormal_myocardial_fiber0.94942720
119MP0005332_abnormal_amino_acid0.94926097
120MP0000639_abnormal_adrenal_gland0.93607398
121MP0002693_abnormal_pancreas_physiology0.93506867
122MP0005647_abnormal_sex_gland0.93159048
123MP0003183_abnormal_peptide_metabolism0.92283592
124MP0002229_neurodegeneration0.91549371
125MP0001529_abnormal_vocalization0.91453891
126MP0003646_muscle_fatigue0.90973021
127MP0004924_abnormal_behavior0.90165622
128MP0005386_behavior/neurological_phenoty0.90165622
129MP0010678_abnormal_skin_adnexa0.89862839
130MP0003868_abnormal_feces_composition0.87156061
131MP0002095_abnormal_skin_pigmentation0.86394186
132MP0002163_abnormal_gland_morphology0.86283535
133MP0000538_abnormal_urinary_bladder0.86220493
134MP0004782_abnormal_surfactant_physiolog0.85393432
135MP0001666_abnormal_nutrient_absorption0.85269379
136MP0003936_abnormal_reproductive_system0.85121557
137MP0003937_abnormal_limbs/digits/tail_de0.84084749
138MP0002882_abnormal_neuron_morphology0.83697865
139MP0003315_abnormal_perineum_morphology0.83056681
140MP0002066_abnormal_motor_capabilities/c0.82817834
141MP0004085_abnormal_heartbeat0.81892461
142MP0002752_abnormal_somatic_nervous0.81687030
143MP0008995_early_reproductive_senescence0.80637719
144MP0004145_abnormal_muscle_electrophysio0.80334666
145MP0003690_abnormal_glial_cell0.80236205
146MP0001661_extended_life_span0.80229228
147MP0000230_abnormal_systemic_arterial0.79768665
148MP0000678_abnormal_parathyroid_gland0.79322178
149MP0000377_abnormal_hair_follicle0.79258384
150MP0005499_abnormal_olfactory_system0.79067500
151MP0005394_taste/olfaction_phenotype0.79067500
152MP0005253_abnormal_eye_physiology0.78553265
153MP0001765_abnormal_ion_homeostasis0.77310948
154MP0002822_catalepsy0.75215560
155MP0005410_abnormal_fertilization0.73292525
156MP0002928_abnormal_bile_duct0.72108373

Predicted human phenotypes

RankGene SetZ-score
1Osteomalacia (HP:0002749)4.40494460
2Focal motor seizures (HP:0011153)4.27373494
3Febrile seizures (HP:0002373)3.86326390
4Hyperventilation (HP:0002883)3.85783117
5Abnormal pancreas size (HP:0012094)3.66957448
6Pancreatic cysts (HP:0001737)3.49184383
7Molar tooth sign on MRI (HP:0002419)3.35725829
8Abnormality of midbrain morphology (HP:0002418)3.35725829
9Conjugated hyperbilirubinemia (HP:0002908)3.20965718
10Hypophosphatemic rickets (HP:0004912)3.18416901
11Abnormality of the renal cortex (HP:0011035)3.17807837
12Broad-based gait (HP:0002136)3.15648203
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.15078904
14Absent/shortened dynein arms (HP:0200106)3.15078904
15Progressive cerebellar ataxia (HP:0002073)3.14773492
16Nephronophthisis (HP:0000090)3.11752100
17Prolonged partial thromboplastin time (HP:0003645)3.09256902
18Abnormal ciliary motility (HP:0012262)3.04199785
19Large for gestational age (HP:0001520)3.03646608
20Parakeratosis (HP:0001036)3.00020887
21Pancreatic fibrosis (HP:0100732)2.96170191
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.92955854
23True hermaphroditism (HP:0010459)2.90569962
24Congenital sensorineural hearing impairment (HP:0008527)2.86967803
25Upper limb muscle weakness (HP:0003484)2.83047120
26Epileptic encephalopathy (HP:0200134)2.82665962
27Atonic seizures (HP:0010819)2.82008966
28Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.79891672
29Ketoacidosis (HP:0001993)2.77591177
30Abnormality of the renal medulla (HP:0100957)2.77204899
31Hypothermia (HP:0002045)2.72289527
32Hyperglycemia (HP:0003074)2.55261165
33Hyperinsulinemic hypoglycemia (HP:0000825)2.52895760
34Abnormality of secondary sexual hair (HP:0009888)2.49974722
35Abnormality of the axillary hair (HP:0100134)2.49974722
36Hypoglycemic coma (HP:0001325)2.48994997
37Abnormal respiratory motile cilium physiology (HP:0012261)2.48595350
38Furrowed tongue (HP:0000221)2.43513829
39Fair hair (HP:0002286)2.42773377
40Focal seizures (HP:0007359)2.42563448
41Decreased central vision (HP:0007663)2.39965859
42Methylmalonic acidemia (HP:0002912)2.37862179
43Erythroderma (HP:0001019)2.36715454
44Metaphyseal irregularity (HP:0003025)2.34922680
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.34051783
46Symptomatic seizures (HP:0011145)2.33338364
47Submucous cleft hard palate (HP:0000176)2.30332523
48Action tremor (HP:0002345)2.29124496
49Generalized hypopigmentation of hair (HP:0011358)2.28437285
50Gaze-evoked nystagmus (HP:0000640)2.28273088
51Abnormality of the nasal septum (HP:0000419)2.28034165
52Abnormality of calcium-phosphate metabolism (HP:0100530)2.27515838
53Synostosis involving the elbow (HP:0003938)2.25649158
54Humeroradial synostosis (HP:0003041)2.25649158
55Ketosis (HP:0001946)2.21297327
56Aplasia/hypoplasia of the uterus (HP:0008684)2.21038908
57Joint hemorrhage (HP:0005261)2.19755122
58Tubular atrophy (HP:0000092)2.19511131
59Cystic liver disease (HP:0006706)2.17940597
60Prostate neoplasm (HP:0100787)2.17749386
61Congenital stationary night blindness (HP:0007642)2.17196502
62Rhinitis (HP:0012384)2.17157241
63Rickets (HP:0002748)2.16241019
64Septo-optic dysplasia (HP:0100842)2.15704852
65Intestinal atresia (HP:0011100)2.15297946
66Decreased circulating renin level (HP:0003351)2.14417766
67Hypoplastic labia majora (HP:0000059)2.14327968
68Abnormality of alanine metabolism (HP:0010916)2.13477356
69Hyperalaninemia (HP:0003348)2.13477356
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13477356
71Abnormal respiratory epithelium morphology (HP:0012253)2.12432492
72Abnormal respiratory motile cilium morphology (HP:0005938)2.12432492
73Renal cortical cysts (HP:0000803)2.12200160
74Aplasia cutis congenita (HP:0001057)2.12140190
75Nonprogressive disorder (HP:0003680)2.12117272
76Hypoplasia of the uterus (HP:0000013)2.11858397
77Hypoglycemic seizures (HP:0002173)2.10399083
78Generalized tonic-clonic seizures (HP:0002069)2.09463721
79Chronic bronchitis (HP:0004469)2.08456002
80Pancreatic islet-cell hyperplasia (HP:0004510)2.07420386
81Cupped ear (HP:0000378)2.07268083
82Distal lower limb muscle weakness (HP:0009053)2.06959191
83Hypoalphalipoproteinemia (HP:0003233)2.06654209
84Metabolic alkalosis (HP:0200114)2.06275018
85Hyperkalemia (HP:0002153)2.06211489
86Palmoplantar hyperkeratosis (HP:0000972)2.06166099
87Confusion (HP:0001289)2.04580605
88Congenital ichthyosiform erythroderma (HP:0007431)2.03980196
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02516933
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.02516933
91Abnormality of renin-angiotensin system (HP:0000847)2.01460089
92Congenital, generalized hypertrichosis (HP:0004540)2.01434794
93Palmar hyperkeratosis (HP:0010765)2.00333397
94Tubulointerstitial nephritis (HP:0001970)2.00026857
95Optic nerve hypoplasia (HP:0000609)1.99766724
96Abnormal drinking behavior (HP:0030082)1.99362372
97Polydipsia (HP:0001959)1.99362372
98Dialeptic seizures (HP:0011146)1.99126808
99Scanning speech (HP:0002168)1.98424749
100Hyperglycinemia (HP:0002154)1.98152441
101Drooling (HP:0002307)1.97730997
102Excessive salivation (HP:0003781)1.97730997
103Absence seizures (HP:0002121)1.97662392
104Protruding tongue (HP:0010808)1.97501541
105Congenital primary aphakia (HP:0007707)1.96125191
106Neoplasm of the adrenal cortex (HP:0100641)1.95300149
107Disproportionate short-trunk short stature (HP:0003521)1.95158521
108Hamartoma of the eye (HP:0010568)1.95142028
109Split foot (HP:0001839)1.94873490
110Hemiparesis (HP:0001269)1.93667052
111Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93505199
112Absent speech (HP:0001344)1.93293496
113Ectropion (HP:0000656)1.92931626
114Gait imbalance (HP:0002141)1.92788292
115Insulin-resistant diabetes mellitus (HP:0000831)1.91873793
116Intrahepatic cholestasis (HP:0001406)1.91538712
117Concave nail (HP:0001598)1.90888626
118Abnormality of the labia majora (HP:0012881)1.90608487
119Genital tract atresia (HP:0001827)1.89924672
120Cerebellar dysplasia (HP:0007033)1.89414140
121Blue irides (HP:0000635)1.88943011
122Abnormality of the renal collecting system (HP:0004742)1.88226380
123Woolly hair (HP:0002224)1.88222171
124Chronic hepatic failure (HP:0100626)1.87621737
125Mixed hearing impairment (HP:0000410)1.87078094
126Abnormality of the middle phalanges of the toes (HP:0010183)1.85105303
127Vaginal atresia (HP:0000148)1.85100767
128Abnormality of endocrine pancreas physiology (HP:0012093)1.84251938
129Abnormality of the pancreatic islet cells (HP:0006476)1.84251938
130Right ventricular cardiomyopathy (HP:0011663)1.83659232
131Stomach cancer (HP:0012126)1.83529248
132Fetal akinesia sequence (HP:0001989)1.83004282
133Neurofibrillary tangles (HP:0002185)1.82017718
134Short tibia (HP:0005736)1.81786010
135Bifid scrotum (HP:0000048)1.80789574
136Nephrogenic diabetes insipidus (HP:0009806)1.80519843
137Abnormal urine phosphate concentration (HP:0012599)1.80471327
138Lip pit (HP:0100267)1.80094971
139Absent eyebrow (HP:0002223)1.79961638
140Abnormality of vitamin B metabolism (HP:0004340)1.79461525
141Short hallux (HP:0010109)1.79357971
142Methylmalonic aciduria (HP:0012120)1.78304672
143Curly hair (HP:0002212)1.78129306
144Glycosuria (HP:0003076)1.78071620
145Abnormality of urine glucose concentration (HP:0011016)1.78071620
146Symphalangism affecting the phalanges of the hand (HP:0009773)1.77827647
147Oligodactyly (hands) (HP:0001180)1.77669399
148Hypoplasia of the fovea (HP:0007750)1.77345635
149Aplasia/Hypoplasia of the fovea (HP:0008060)1.77345635
150Aplasia involving bones of the extremities (HP:0009825)1.77290088
151Aplasia involving bones of the upper limbs (HP:0009823)1.77290088
152Aplasia of the phalanges of the hand (HP:0009802)1.77290088
153Medial flaring of the eyebrow (HP:0010747)1.76994529
154Tachypnea (HP:0002789)1.76909592
155Patchy hypopigmentation of hair (HP:0011365)1.76582070
156Increased circulating renin level (HP:0000848)1.76106365
157Hyperactive renin-angiotensin system (HP:0000841)1.75460760
158Abnormality of incisor morphology (HP:0011063)1.74851470
159Hypomagnesemia (HP:0002917)1.74646689
160Abnormality of salivation (HP:0100755)1.74518631
161Abnormality of the corticospinal tract (HP:0002492)1.74241045
162Attenuation of retinal blood vessels (HP:0007843)1.73803767
163Male pseudohermaphroditism (HP:0000037)1.73531660
164Hepatic necrosis (HP:0002605)1.72761678
165Conjunctival hamartoma (HP:0100780)1.71386158
166Abolished electroretinogram (ERG) (HP:0000550)1.71236663
167Abnormality of binocular vision (HP:0011514)1.71166817
168Diplopia (HP:0000651)1.71166817
169Abnormality of magnesium homeostasis (HP:0004921)1.71016092
170Nasolacrimal duct obstruction (HP:0000579)1.70784750
171Aplasia/Hypoplasia of the tongue (HP:0010295)1.70351946
172Hypophosphatemia (HP:0002148)1.69815387
173Duplicated collecting system (HP:0000081)1.68195032
174Chorioretinal atrophy (HP:0000533)1.67640185
175Adrenal hypoplasia (HP:0000835)1.66456115
176Aplasia/Hypoplasia of the hallux (HP:0008362)1.66313786
177Plantar hyperkeratosis (HP:0007556)1.65965686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.25553004
2INSRR3.86346010
3TNIK3.12579481
4TRIM282.90425616
5ACVR1B2.37043100
6NTRK32.22219623
7MAPK152.21419445
8ADRBK22.16460795
9OXSR12.02591270
10STK391.92878332
11AKT31.92703539
12STK31.89319217
13MAP2K71.85507574
14MAP4K21.75443124
15STK161.74119038
16BMPR1B1.71388671
17STK38L1.69557226
18IRAK31.60664009
19GRK11.57931859
20PRPF4B1.46998156
21BRSK21.46779759
22STK241.42880654
23PINK11.42605221
24PKN11.40882502
25PDK21.39854423
26NEK61.39462887
27TAOK31.37806023
28PAK31.32784055
29EIF2AK31.32493436
30EPHA41.29918464
31WNK11.28073218
32BMPR21.25964336
33WNK41.22529556
34TGFBR11.22415311
35GRK71.21452618
36CAMK2B1.16616394
37NEK91.15727002
38HIPK21.14968149
39MAPK131.13741209
40CDK31.13078126
41IRAK21.12550687
42SGK2231.10880088
43SGK4941.10880088
44MAP3K41.10457225
45MAP3K21.09956638
46BCR1.09884844
47PRKCE1.06848766
48PIK3CG1.05955271
49PNCK1.05748478
50RIPK41.05727669
51IRAK11.05271910
52DAPK21.05172718
53CAMKK21.04425599
54FRK1.02261826
55LATS11.01968171
56SGK21.01421466
57EIF2AK21.01380364
58YES11.00030255
59TRPM70.97670058
60CDK190.97605496
61MUSK0.97527237
62CAMK2A0.97445238
63MAPKAPK30.97277724
64MARK10.95029002
65MET0.94297420
66MAPKAPK50.94076306
67CAMK2D0.93678136
68NTRK20.92850083
69IRAK40.92134367
70NUAK10.91035144
71PRKD30.90716562
72NEK20.90464529
73EPHA30.88596216
74MAP3K140.88391427
75WEE10.87025632
76EPHB10.83092706
77UHMK10.83089555
78FGR0.80096182
79MST1R0.79456019
80CSNK1G10.76649018
81BLK0.76408073
82TLK10.76055431
83GRK50.75366776
84PHKG10.74634498
85PHKG20.74634498
86CAMK2G0.74524894
87PRKG10.72928050
88SGK10.71775568
89ERBB30.71612887
90MAP2K40.71087646
91PASK0.70719363
92PRKAA20.68988818
93PIK3CA0.68280790
94NLK0.68201204
95CDC42BPA0.65537349
96FES0.64232053
97WNK30.63292606
98CDK50.63128019
99ERBB40.62852051
100SIK20.62277497
101EPHA20.61929133
102FER0.61539455
103PTK2B0.60945639
104PRKCG0.60701357
105TNK20.59650855
106RPS6KB10.59097908
107DYRK1A0.58914208
108ZAK0.58632072
109CAMK10.58454472
110MST40.58333372
111TXK0.56522483
112MKNK20.55655363
113PRKACA0.55140535
114PLK20.52776786
115ADRBK10.52050466
116PBK0.51892598
117CHUK0.51506216
118FGFR20.50462163
119PLK30.49299185
120TEC0.49236272
121PRKCI0.48894629
122STK110.48653983
123MAPK70.47881715
124CSNK1A10.47806014
125PRKCH0.47359450
126MAP3K120.46591012
127PRKCQ0.46589034
128MAP2K60.46381430
129SIK30.45759597
130SGK30.44883512
131PRKCA0.44302230
132NME10.44059152
133MELK0.43208979
134PRKAA10.43085531
135CSNK1G20.42805522
136TAF10.42447886
137FGFR10.40125214
138NTRK10.39006004
139IKBKB0.37728939
140CSNK1A1L0.35575505
141CAMK40.33171596
142CSNK1D0.32906264
143CAMK1G0.32597527
144OBSCN0.31710874

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.47602710
2Nicotine addiction_Homo sapiens_hsa050333.35541501
3Sulfur metabolism_Homo sapiens_hsa009202.90035766
4Selenocompound metabolism_Homo sapiens_hsa004502.29914191
5Taste transduction_Homo sapiens_hsa047422.27060933
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23795976
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17352717
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03144112
9Nitrogen metabolism_Homo sapiens_hsa009101.95425191
10Glutamatergic synapse_Homo sapiens_hsa047241.88035151
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84885852
12Fatty acid elongation_Homo sapiens_hsa000621.81606060
13Propanoate metabolism_Homo sapiens_hsa006401.81051908
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76674350
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75506971
16Morphine addiction_Homo sapiens_hsa050321.68093216
17Histidine metabolism_Homo sapiens_hsa003401.67286917
18Serotonergic synapse_Homo sapiens_hsa047261.67040413
19Insulin secretion_Homo sapiens_hsa049111.65274876
20GABAergic synapse_Homo sapiens_hsa047271.63723274
21Phototransduction_Homo sapiens_hsa047441.62974520
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62180634
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.60405658
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.54231587
25Amphetamine addiction_Homo sapiens_hsa050311.53760083
26Steroid biosynthesis_Homo sapiens_hsa001001.53271566
27Sphingolipid metabolism_Homo sapiens_hsa006001.51110965
28ABC transporters_Homo sapiens_hsa020101.45259013
29Caffeine metabolism_Homo sapiens_hsa002321.42496189
30Circadian entrainment_Homo sapiens_hsa047131.41595472
31Collecting duct acid secretion_Homo sapiens_hsa049661.41001508
32Ether lipid metabolism_Homo sapiens_hsa005651.38590970
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37129374
34Salivary secretion_Homo sapiens_hsa049701.35922865
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34478770
36Oxidative phosphorylation_Homo sapiens_hsa001901.32339421
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29350276
38Basal transcription factors_Homo sapiens_hsa030221.21935385
39Synaptic vesicle cycle_Homo sapiens_hsa047211.21827516
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21569213
41Cocaine addiction_Homo sapiens_hsa050301.20703546
42Chemical carcinogenesis_Homo sapiens_hsa052041.18427043
43Long-term depression_Homo sapiens_hsa047301.17460818
44Retinol metabolism_Homo sapiens_hsa008301.17397911
45Homologous recombination_Homo sapiens_hsa034401.14412979
46Protein export_Homo sapiens_hsa030601.11062897
47Linoleic acid metabolism_Homo sapiens_hsa005911.10845782
48Pancreatic secretion_Homo sapiens_hsa049721.10005067
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05948655
50Butanoate metabolism_Homo sapiens_hsa006501.05439118
51Mineral absorption_Homo sapiens_hsa049781.05418186
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04455527
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02761017
54Calcium signaling pathway_Homo sapiens_hsa040201.01950509
55Long-term potentiation_Homo sapiens_hsa047201.00071752
56Fatty acid degradation_Homo sapiens_hsa000710.99180754
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95718237
58Circadian rhythm_Homo sapiens_hsa047100.95283302
59Vitamin digestion and absorption_Homo sapiens_hsa049770.95110540
60Alzheimers disease_Homo sapiens_hsa050100.93750500
61Phenylalanine metabolism_Homo sapiens_hsa003600.93457137
62Tryptophan metabolism_Homo sapiens_hsa003800.92256534
63Renin secretion_Homo sapiens_hsa049240.92228138
64TGF-beta signaling pathway_Homo sapiens_hsa043500.88289639
65Axon guidance_Homo sapiens_hsa043600.88244478
66Dopaminergic synapse_Homo sapiens_hsa047280.88147547
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86919317
68Type II diabetes mellitus_Homo sapiens_hsa049300.86394808
69RNA polymerase_Homo sapiens_hsa030200.85258145
70Tyrosine metabolism_Homo sapiens_hsa003500.84869149
71RNA degradation_Homo sapiens_hsa030180.84501574
72Cholinergic synapse_Homo sapiens_hsa047250.80506464
73Gastric acid secretion_Homo sapiens_hsa049710.78663173
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77906120
75Arachidonic acid metabolism_Homo sapiens_hsa005900.77528619
76Ovarian steroidogenesis_Homo sapiens_hsa049130.76739205
77Rheumatoid arthritis_Homo sapiens_hsa053230.76304368
78beta-Alanine metabolism_Homo sapiens_hsa004100.74193733
79Non-homologous end-joining_Homo sapiens_hsa034500.73113949
80Vibrio cholerae infection_Homo sapiens_hsa051100.73038540
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72899179
82Olfactory transduction_Homo sapiens_hsa047400.70667852
83Bile secretion_Homo sapiens_hsa049760.70040048
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.69647399
85cAMP signaling pathway_Homo sapiens_hsa040240.66880806
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65053255
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65007919
88Fanconi anemia pathway_Homo sapiens_hsa034600.64940318
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64293738
90Complement and coagulation cascades_Homo sapiens_hsa046100.63454856
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.63150526
92One carbon pool by folate_Homo sapiens_hsa006700.62793771
93Fatty acid metabolism_Homo sapiens_hsa012120.60534808
94Glycerolipid metabolism_Homo sapiens_hsa005610.58427543
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57033755
96Inositol phosphate metabolism_Homo sapiens_hsa005620.57017958
97Metabolic pathways_Homo sapiens_hsa011000.56726911
98Tight junction_Homo sapiens_hsa045300.54587544
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54325432
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54117015
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53558753
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53547003
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53501641
104Peroxisome_Homo sapiens_hsa041460.52913680
105Regulation of autophagy_Homo sapiens_hsa041400.50277703
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49399370
107Fat digestion and absorption_Homo sapiens_hsa049750.48879292
108Hedgehog signaling pathway_Homo sapiens_hsa043400.48463089
109Cardiac muscle contraction_Homo sapiens_hsa042600.48313799
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47773773
111Arginine and proline metabolism_Homo sapiens_hsa003300.46235644
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.45751265
113Melanogenesis_Homo sapiens_hsa049160.45137760
114Starch and sucrose metabolism_Homo sapiens_hsa005000.44860687
115Autoimmune thyroid disease_Homo sapiens_hsa053200.44135363
116African trypanosomiasis_Homo sapiens_hsa051430.43388389
117Vitamin B6 metabolism_Homo sapiens_hsa007500.42838825
118Lysine degradation_Homo sapiens_hsa003100.42575365
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41956711
120Glutathione metabolism_Homo sapiens_hsa004800.41801307
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41073245
122Glucagon signaling pathway_Homo sapiens_hsa049220.40914277
123Oxytocin signaling pathway_Homo sapiens_hsa049210.40881250
124PPAR signaling pathway_Homo sapiens_hsa033200.40767770
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40261460
126Type I diabetes mellitus_Homo sapiens_hsa049400.40020546
127Hippo signaling pathway_Homo sapiens_hsa043900.39111698
128Fatty acid biosynthesis_Homo sapiens_hsa000610.37997173
129Dorso-ventral axis formation_Homo sapiens_hsa043200.37514007
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37269653
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37222420
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37114367
133Huntingtons disease_Homo sapiens_hsa050160.34513288
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.34202376
135Purine metabolism_Homo sapiens_hsa002300.33862705

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