EXOSC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.00263073
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.90850551
3central nervous system myelination (GO:0022010)5.71179262
4axon ensheathment in central nervous system (GO:0032291)5.71179262
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.66945774
6ATP synthesis coupled proton transport (GO:0015986)5.66945774
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.06104501
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.99742256
9DNA replication checkpoint (GO:0000076)4.78341405
10viral transcription (GO:0019083)4.49575692
11establishment of integrated proviral latency (GO:0075713)4.47070483
12DNA strand elongation (GO:0022616)4.46715682
13protein neddylation (GO:0045116)4.39505334
14translational termination (GO:0006415)4.35435547
15maturation of SSU-rRNA (GO:0030490)4.27115716
16proteasome assembly (GO:0043248)4.20320072
17nucleobase biosynthetic process (GO:0046112)4.16545768
18telomere maintenance via semi-conservative replication (GO:0032201)4.16263714
19chaperone-mediated protein transport (GO:0072321)4.10488667
20respiratory electron transport chain (GO:0022904)4.06129531
21chromatin remodeling at centromere (GO:0031055)4.02599381
22nuclear pore complex assembly (GO:0051292)3.97595932
23electron transport chain (GO:0022900)3.95498421
24cotranslational protein targeting to membrane (GO:0006613)3.94328120
25transcription elongation from RNA polymerase III promoter (GO:0006385)3.91444031
26termination of RNA polymerase III transcription (GO:0006386)3.91444031
27CENP-A containing nucleosome assembly (GO:0034080)3.89944866
28nuclear pore organization (GO:0006999)3.89269068
29ribosome assembly (GO:0042255)3.84956426
30protein targeting to ER (GO:0045047)3.83916915
31establishment of viral latency (GO:0019043)3.83620588
32replication fork processing (GO:0031297)3.82741953
33long-chain fatty acid biosynthetic process (GO:0042759)3.82223179
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80576976
35mitotic sister chromatid segregation (GO:0000070)3.77473489
36purine nucleobase biosynthetic process (GO:0009113)3.70697696
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68442814
38pseudouridine synthesis (GO:0001522)3.66666319
39ribosomal large subunit biogenesis (GO:0042273)3.66089507
40telomere maintenance via recombination (GO:0000722)3.62882576
41protein localization to endoplasmic reticulum (GO:0070972)3.61978235
42DNA unwinding involved in DNA replication (GO:0006268)3.61686894
43mitotic metaphase plate congression (GO:0007080)3.59852456
44GTP biosynthetic process (GO:0006183)3.59031186
45positive regulation of protein homodimerization activity (GO:0090073)3.56182003
46cellular protein complex disassembly (GO:0043624)3.51453451
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.48419021
48viral life cycle (GO:0019058)3.48314817
49sister chromatid segregation (GO:0000819)3.48097312
50translational elongation (GO:0006414)3.47916449
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.47581957
52somatic diversification of immune receptors via somatic mutation (GO:0002566)3.47581957
53DNA damage response, detection of DNA damage (GO:0042769)3.47206685
54IMP biosynthetic process (GO:0006188)3.46712409
55mitochondrial RNA metabolic process (GO:0000959)3.46643585
56mitotic recombination (GO:0006312)3.46062905
57ribosomal small subunit assembly (GO:0000028)3.44999445
58ribosome biogenesis (GO:0042254)3.44908490
59protein localization to kinetochore (GO:0034501)3.44628633
60regulation of centriole replication (GO:0046599)3.41865055
61DNA replication-dependent nucleosome assembly (GO:0006335)3.41043110
62DNA replication-dependent nucleosome organization (GO:0034723)3.41043110
63kinetochore organization (GO:0051383)3.40039200
64RNA capping (GO:0036260)3.39898165
657-methylguanosine RNA capping (GO:0009452)3.39898165
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.39618202
67regulation of mitotic spindle checkpoint (GO:1903504)3.39618202
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.39079848
697-methylguanosine mRNA capping (GO:0006370)3.37458862
70meiotic chromosome segregation (GO:0045132)3.32686869
71non-recombinational repair (GO:0000726)3.31401436
72double-strand break repair via nonhomologous end joining (GO:0006303)3.31401436
73mitotic nuclear envelope disassembly (GO:0007077)3.31229777
74histone H2B ubiquitination (GO:0033523)3.29374896
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28718707
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.28718707
77NADH dehydrogenase complex assembly (GO:0010257)3.28718707
78cholesterol biosynthetic process (GO:0006695)3.28718532
79negative regulation of DNA-dependent DNA replication (GO:2000104)3.28551510
80translational initiation (GO:0006413)3.27396563
81regulation of translational fidelity (GO:0006450)3.25583647
82folic acid-containing compound biosynthetic process (GO:0009396)3.24042822
83UTP biosynthetic process (GO:0006228)3.23896038
84histone exchange (GO:0043486)3.23023396
85regulation of nuclear cell cycle DNA replication (GO:0033262)3.22344873
86neuron cell-cell adhesion (GO:0007158)3.21710842
87telomere maintenance via telomere lengthening (GO:0010833)3.21210647
88DNA replication-independent nucleosome assembly (GO:0006336)3.19957938
89DNA replication-independent nucleosome organization (GO:0034724)3.19957938
90metaphase plate congression (GO:0051310)3.19290987
91glycerophospholipid catabolic process (GO:0046475)3.18461531
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17317792
93translation (GO:0006412)3.17063911
94formation of translation preinitiation complex (GO:0001731)3.16817495
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15783763
96pore complex assembly (GO:0046931)3.15699719
97ribonucleoprotein complex biogenesis (GO:0022613)3.14864525
98transcription elongation from RNA polymerase I promoter (GO:0006362)3.14724072
99regulation of centrosome cycle (GO:0046605)3.12095212
100protein complex biogenesis (GO:0070271)3.11745202
101DNA catabolic process, exonucleolytic (GO:0000738)3.09138587
102spliceosomal complex assembly (GO:0000245)3.08628026
103positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.08619494
104myelination (GO:0042552)3.04587874
105isoprenoid biosynthetic process (GO:0008299)3.03806595
106protein localization to chromosome, centromeric region (GO:0071459)3.03488348
107kinetochore assembly (GO:0051382)3.01368524
108mitotic chromosome condensation (GO:0007076)3.00894143
109axon ensheathment (GO:0008366)3.00537393
110ensheathment of neurons (GO:0007272)3.00537393
111spliceosomal snRNP assembly (GO:0000387)2.99714484
112establishment of protein localization to mitochondrion (GO:0072655)2.99230219
113membrane disassembly (GO:0030397)2.99191468
114nuclear envelope disassembly (GO:0051081)2.99191468
115dopamine transport (GO:0015872)2.98064880
116DNA double-strand break processing (GO:0000729)2.97874327
117* ncRNA processing (GO:0034470)2.97425200
118protein targeting to mitochondrion (GO:0006626)2.96030730
119regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95141111
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94441198
121sterol biosynthetic process (GO:0016126)2.93684298
122peptidyl-histidine modification (GO:0018202)2.93648199
123IMP metabolic process (GO:0046040)2.93636295
124protein K6-linked ubiquitination (GO:0085020)2.91462551
125transcription from mitochondrial promoter (GO:0006390)2.91316480
126dopamine biosynthetic process (GO:0042416)2.91279756
127* ncRNA metabolic process (GO:0034660)2.91106190
128* rRNA processing (GO:0006364)2.90750115
129protein complex disassembly (GO:0043241)2.90606873
130mitochondrial respiratory chain complex assembly (GO:0033108)2.89888277
131tRNA methylation (GO:0030488)2.89803463
132cellular component biogenesis (GO:0044085)2.89780851
133negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89532928
134viral mRNA export from host cell nucleus (GO:0046784)2.89372197
135spindle checkpoint (GO:0031577)2.87711052
136amino acid activation (GO:0043038)2.87537023
137tRNA aminoacylation (GO:0043039)2.87537023
138tRNA metabolic process (GO:0006399)2.86895125
139termination of RNA polymerase I transcription (GO:0006363)2.86543781
140transcription-coupled nucleotide-excision repair (GO:0006283)2.86289769
141tRNA aminoacylation for protein translation (GO:0006418)2.83482288
142tRNA processing (GO:0008033)2.83426262
143negative regulation of ligase activity (GO:0051352)2.82746539
144negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82746539
145presynaptic membrane organization (GO:0097090)2.80698455
146maturation of 5.8S rRNA (GO:0000460)2.80071086
147presynaptic membrane assembly (GO:0097105)2.80003269
148fatty acid elongation (GO:0030497)2.79704022
149* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78636110
150substantia nigra development (GO:0021762)2.78444314
151* rRNA metabolic process (GO:0016072)2.77845041
152negative regulation of protein localization to cell surface (GO:2000009)2.77053627
153regulation of transmission of nerve impulse (GO:0051969)2.76385797
154regulation of cellular amino acid metabolic process (GO:0006521)2.75532327
155macromolecular complex disassembly (GO:0032984)2.75068176
156microtubule polymerization or depolymerization (GO:0031109)2.74808286
157purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74574293
158deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.71759562
159preassembly of GPI anchor in ER membrane (GO:0016254)2.69982922
160DNA ligation (GO:0006266)2.68029363
161transcription from RNA polymerase I promoter (GO:0006360)2.67467064
162regulation of mitochondrial translation (GO:0070129)2.67213317
163rRNA modification (GO:0000154)2.65137650
164purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64364391
165* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64308480
166DNA strand elongation involved in DNA replication (GO:0006271)2.61932986
167GPI anchor biosynthetic process (GO:0006506)2.60644181
168positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60333698
169DNA replication initiation (GO:0006270)2.60264714
170protein localization to mitochondrion (GO:0070585)2.60258162
171positive regulation of response to oxidative stress (GO:1902884)2.60231856
172positive regulation of cellular response to oxidative stress (GO:1900409)2.60231856
173guanosine-containing compound biosynthetic process (GO:1901070)2.59684496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.04212324
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14539138
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99392387
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.86536129
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.78163955
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.40124677
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.28447360
8* MYC_18555785_ChIP-Seq_MESCs_Mouse2.96430806
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88475442
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73954067
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71101021
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.69251678
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67245334
14E2F7_22180533_ChIP-Seq_HELA_Human2.60520775
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53781170
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.40282237
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37546315
18TAF15_26573619_Chip-Seq_HEK293_Human2.33386083
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24102251
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.18691025
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.18691025
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.18691025
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13384519
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09881115
25FUS_26573619_Chip-Seq_HEK293_Human2.09467299
26EZH2_22144423_ChIP-Seq_EOC_Human2.08984224
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07814016
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97440306
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95480040
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.91886138
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89945343
32* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89488487
33AR_21909140_ChIP-Seq_LNCAP_Human1.86150298
34ELK1_19687146_ChIP-ChIP_HELA_Human1.81758879
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.81549634
36VDR_23849224_ChIP-Seq_CD4+_Human1.73999969
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.72919397
38KDM5A_27292631_Chip-Seq_BREAST_Human1.72613326
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66968983
40VDR_22108803_ChIP-Seq_LS180_Human1.62358212
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60844192
42DCP1A_22483619_ChIP-Seq_HELA_Human1.57764367
43* XRN2_22483619_ChIP-Seq_HELA_Human1.57387935
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56254846
45* TTF2_22483619_ChIP-Seq_HELA_Human1.55482877
46ZNF274_21170338_ChIP-Seq_K562_Hela1.50211308
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48236545
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48009167
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46956320
50GBX2_23144817_ChIP-Seq_PC3_Human1.46852506
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.46614450
52EWS_26573619_Chip-Seq_HEK293_Human1.45469855
53* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43973730
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.43693343
55* YY1_21170310_ChIP-Seq_MESCs_Mouse1.43147602
56IRF1_19129219_ChIP-ChIP_H3396_Human1.43106851
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42375200
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.39723301
59RNF2_27304074_Chip-Seq_NSC_Mouse1.34339655
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34039990
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33743138
62FOXP3_21729870_ChIP-Seq_TREG_Human1.32240651
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30458127
64* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30089519
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29194340
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28255133
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.26710208
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.25140407
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22702044
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20691584
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19185651
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.18366342
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17989249
74* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17905798
75ER_23166858_ChIP-Seq_MCF-7_Human1.17316695
76* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16776474
77* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16290220
78MYC_18940864_ChIP-ChIP_HL60_Human1.14506211
79* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13895063
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13780095
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13477717
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12902034
83* CIITA_25753668_ChIP-Seq_RAJI_Human1.12093921
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12064790
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12062431
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10496482
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.09050586
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08422478
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07917633
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06813181
91BP1_19119308_ChIP-ChIP_Hs578T_Human1.05941296
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05586339
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05354999
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04188558
95IGF1R_20145208_ChIP-Seq_DFB_Human1.03919260
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03525455
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02845356
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.02638405
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01488878
100EED_16625203_ChIP-ChIP_MESCs_Mouse1.00580493
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99144079
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96858945
103P300_19829295_ChIP-Seq_ESCs_Human0.96780000
104PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95598722
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92355189
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91469875
107* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87904043
108SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86767190
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86744716
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85009281
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83719766
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83531071
113MYCN_18555785_ChIP-Seq_MESCs_Mouse0.83098605
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82652649
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.82531674
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82293926
117SMAD3_21741376_ChIP-Seq_EPCs_Human0.81725150
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81295374
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80161377
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.79284418
121* GABP_19822575_ChIP-Seq_HepG2_Human0.78998172
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78753327
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78655312
124HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78234034
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77861902
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77674339
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.77518965
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76852702
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73642644
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72710496
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69315317
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69314197
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68203376
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.67786731
135KLF4_18555785_ChIP-Seq_MESCs_Mouse0.66298042
136TFEB_21752829_ChIP-Seq_HELA_Human0.64005280
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.63483942
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.63431209
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.62663998
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61785923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.33349120
2MP0001529_abnormal_vocalization3.59472428
3MP0005409_darkened_coat_color3.56863403
4MP0009379_abnormal_foot_pigmentation3.56740851
5MP0008057_abnormal_DNA_replication3.39271694
6MP0001905_abnormal_dopamine_level3.08129748
7MP0003136_yellow_coat_color2.89230202
8MP0008007_abnormal_cellular_replicative2.79186110
9MP0009697_abnormal_copulation2.29687177
10MP0001188_hyperpigmentation2.29504725
11MP0006292_abnormal_olfactory_placode2.20361934
12MP0006276_abnormal_autonomic_nervous2.18737908
13MP0004270_analgesia2.07039827
14MP0005171_absent_coat_pigmentation2.05798877
15MP0004142_abnormal_muscle_tone2.02542769
16MP0002102_abnormal_ear_morphology1.96357373
17MP0005423_abnormal_somatic_nervous1.90477349
18MP0005645_abnormal_hypothalamus_physiol1.87909751
19MP0000920_abnormal_myelination1.85639530
20MP0000778_abnormal_nervous_system1.78632862
21MP0000566_synostosis1.78449988
22MP0004742_abnormal_vestibular_system1.77760683
23MP0002272_abnormal_nervous_system1.73049155
24MP0002938_white_spotting1.72645342
25MP0000350_abnormal_cell_proliferation1.72396943
26MP0001486_abnormal_startle_reflex1.71268872
27MP0001293_anophthalmia1.65905622
28MP0002734_abnormal_mechanical_nocicepti1.65456512
29MP0003938_abnormal_ear_development1.64932122
30MP0008877_abnormal_DNA_methylation1.63901423
31MP0001440_abnormal_grooming_behavior1.63653626
32MP0002064_seizures1.61478921
33MP0001730_embryonic_growth_arrest1.60018258
34MP0001727_abnormal_embryo_implantation1.57927601
35MP0010307_abnormal_tumor_latency1.56686407
36MP0001485_abnormal_pinna_reflex1.53257216
37MP0008932_abnormal_embryonic_tissue1.52974096
38MP0009745_abnormal_behavioral_response1.52701483
39MP0004381_abnormal_hair_follicle1.50489515
40MP0002572_abnormal_emotion/affect_behav1.50231825
41MP0001697_abnormal_embryo_size1.49002957
42MP0002736_abnormal_nociception_after1.48277934
43MP0008789_abnormal_olfactory_epithelium1.47381701
44MP0001968_abnormal_touch/_nociception1.46163315
45MP0001672_abnormal_embryogenesis/_devel1.45374107
46MP0005380_embryogenesis_phenotype1.45374107
47MP0003806_abnormal_nucleotide_metabolis1.45291836
48MP0002751_abnormal_autonomic_nervous1.43399504
49MP0003718_maternal_effect1.43119185
50MP0003567_abnormal_fetal_cardiomyocyte1.40545189
51MP0000462_abnormal_digestive_system1.38388415
52MP0006072_abnormal_retinal_apoptosis1.36296972
53MP0008058_abnormal_DNA_repair1.35209353
54MP0002084_abnormal_developmental_patter1.33491446
55MP0003635_abnormal_synaptic_transmissio1.33219607
56MP0002085_abnormal_embryonic_tissue1.32562246
57MP0002735_abnormal_chemical_nociception1.32230022
58MP0005379_endocrine/exocrine_gland_phen1.30575042
59MP0003950_abnormal_plasma_membrane1.30329217
60MP0004957_abnormal_blastocyst_morpholog1.30095084
61MP0002080_prenatal_lethality1.25775728
62MP0000313_abnormal_cell_death1.24215780
63MP0005394_taste/olfaction_phenotype1.23627958
64MP0005499_abnormal_olfactory_system1.23627958
65MP0010094_abnormal_chromosome_stability1.23308452
66MP0003122_maternal_imprinting1.23053200
67MP0004133_heterotaxia1.22586326
68MP0003984_embryonic_growth_retardation1.21520147
69MP0000026_abnormal_inner_ear1.20817814
70MP0002067_abnormal_sensory_capabilities1.20305914
71MP0002752_abnormal_somatic_nervous1.20022939
72MP0009046_muscle_twitch1.19855519
73MP0010030_abnormal_orbit_morphology1.19291528
74MP0002088_abnormal_embryonic_growth/wei1.18443806
75MP0006036_abnormal_mitochondrial_physio1.18408112
76MP0002184_abnormal_innervation1.17614940
77MP0001970_abnormal_pain_threshold1.17586790
78MP0004197_abnormal_fetal_growth/weight/1.17440473
79MP0001963_abnormal_hearing_physiology1.16982505
80MP0001929_abnormal_gametogenesis1.14484028
81MP0009672_abnormal_birth_weight1.13001842
82MP0003937_abnormal_limbs/digits/tail_de1.12413241
83MP0000631_abnormal_neuroendocrine_gland1.11320915
84MP0005386_behavior/neurological_phenoty1.10910456
85MP0004924_abnormal_behavior1.10910456
86MP0002822_catalepsy1.09602342
87MP0002396_abnormal_hematopoietic_system1.08319655
88MP0003890_abnormal_embryonic-extraembry1.08143534
89MP0001286_abnormal_eye_development1.08127775
90MP0001145_abnormal_male_reproductive1.07886540
91MP0005551_abnormal_eye_electrophysiolog1.06885585
92MP0002234_abnormal_pharynx_morphology1.05966781
93MP0002277_abnormal_respiratory_mucosa1.04684968
94MP0003693_abnormal_embryo_hatching1.04279861
95MP0000358_abnormal_cell_content/1.04232663
96MP0003186_abnormal_redox_activity1.04049852
97MP0003315_abnormal_perineum_morphology1.03346760
98MP0002882_abnormal_neuron_morphology1.02867658
99MP0002733_abnormal_thermal_nociception1.02326229
100MP0002063_abnormal_learning/memory/cond0.99563225
101MP0003121_genomic_imprinting0.98591540
102MP0004145_abnormal_muscle_electrophysio0.98380627
103MP0003077_abnormal_cell_cycle0.97769203
104MP0005410_abnormal_fertilization0.97765100
105MP0000653_abnormal_sex_gland0.97631574
106MP0002163_abnormal_gland_morphology0.96884328
107MP0002111_abnormal_tail_morphology0.96752787
108MP0002697_abnormal_eye_size0.95995350
109MP0001346_abnormal_lacrimal_gland0.95665799
110MP0003786_premature_aging0.95317916
111MP0003119_abnormal_digestive_system0.94479442
112MP0005408_hypopigmentation0.93478397
113MP0002160_abnormal_reproductive_system0.90935977
114MP0005389_reproductive_system_phenotype0.90755486
115MP0002019_abnormal_tumor_incidence0.88546955
116MP0003123_paternal_imprinting0.87363621
117MP0006035_abnormal_mitochondrial_morpho0.86190605
118MP0003111_abnormal_nucleus_morphology0.86184003
119MP0003634_abnormal_glial_cell0.85721323
120MP0002066_abnormal_motor_capabilities/c0.85553180
121MP0002229_neurodegeneration0.84480452
122MP0010352_gastrointestinal_tract_polyps0.83282845
123MP0005253_abnormal_eye_physiology0.83158613
124MP0002557_abnormal_social/conspecific_i0.82295099
125MP0008995_early_reproductive_senescence0.81969944
126MP0000762_abnormal_tongue_morphology0.81863228
127MP0005075_abnormal_melanosome_morpholog0.81495814
128MP0003632_abnormal_nervous_system0.80770162
129MP0000955_abnormal_spinal_cord0.80504253
130MP0000372_irregular_coat_pigmentation0.80048046
131MP0002233_abnormal_nose_morphology0.79894768
132MP0003861_abnormal_nervous_system0.79350407
133MP0002086_abnormal_extraembryonic_tissu0.78857037
134MP0002152_abnormal_brain_morphology0.78719595
135MP0003698_abnormal_male_reproductive0.77997059
136MP0000049_abnormal_middle_ear0.77577614
137MP0002210_abnormal_sex_determination0.76966271
138MP0001119_abnormal_female_reproductive0.76739025
139MP0000427_abnormal_hair_cycle0.75673393
140MP0001986_abnormal_taste_sensitivity0.75442146
141MP0003941_abnormal_skin_development0.75314033
142MP0003943_abnormal_hepatobiliary_system0.74948702
143MP0001919_abnormal_reproductive_system0.73797383
144MP0008872_abnormal_physiological_respon0.71476466
145MP0005391_vision/eye_phenotype0.69299049
146MP0009703_decreased_birth_body0.68378514
147MP0003755_abnormal_palate_morphology0.67252941
148MP0001661_extended_life_span0.67083206
149MP0000647_abnormal_sebaceous_gland0.66528278
150MP0001764_abnormal_homeostasis0.66175018
151MP0002095_abnormal_skin_pigmentation0.65810599
152MP0005395_other_phenotype0.65554160
153MP0000537_abnormal_urethra_morphology0.63644962
154MP0000490_abnormal_crypts_of0.63460358
155MP0002161_abnormal_fertility/fecundity0.61987901
156MP0004233_abnormal_muscle_weight0.61975930
157MP0003646_muscle_fatigue0.61803142
158MP0002009_preneoplasia0.57790589
159MP0004147_increased_porphyrin_level0.57771159
160MP0001324_abnormal_eye_pigmentation0.56329280

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.77350696
2Chromsome breakage (HP:0040012)4.41800768
3Acute necrotizing encephalopathy (HP:0006965)4.28565359
4Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.92513689
5Parakeratosis (HP:0001036)3.85439829
6Mitochondrial inheritance (HP:0001427)3.83331195
7Increased hepatocellular lipid droplets (HP:0006565)3.76947835
8Renal Fanconi syndrome (HP:0001994)3.60524482
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.59402423
10Colon cancer (HP:0003003)3.56664850
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.54691192
12Abnormality of cells of the erythroid lineage (HP:0012130)3.53196073
13Progressive macrocephaly (HP:0004481)3.49569669
14Cerebral hypomyelination (HP:0006808)3.46261233
15Abnormal mitochondria in muscle tissue (HP:0008316)3.45851384
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.42407520
17Meckel diverticulum (HP:0002245)3.42197836
183-Methylglutaconic aciduria (HP:0003535)3.36289164
19Abnormality of the ileum (HP:0001549)3.32033523
20Abnormality of the preputium (HP:0100587)3.29320801
21Abnormality of chromosome stability (HP:0003220)3.22133146
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.19833935
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.19833935
24Acute encephalopathy (HP:0006846)3.16996443
25Progressive external ophthalmoplegia (HP:0000590)3.15484743
26Macrocytic anemia (HP:0001972)3.15157955
27Reticulocytopenia (HP:0001896)3.09400897
28Increased CSF lactate (HP:0002490)3.08489027
29Lipid accumulation in hepatocytes (HP:0006561)3.02883875
30Abnormal number of erythroid precursors (HP:0012131)3.00720133
31Leukodystrophy (HP:0002415)3.00178645
32Increased serum pyruvate (HP:0003542)2.94287209
33Abnormality of glycolysis (HP:0004366)2.94287209
34Hepatocellular necrosis (HP:0001404)2.88288489
35Breast hypoplasia (HP:0003187)2.77868968
36Optic disc pallor (HP:0000543)2.77155242
37Sensory axonal neuropathy (HP:0003390)2.74480970
38Absent thumb (HP:0009777)2.65485009
39Abnormality of secondary sexual hair (HP:0009888)2.63361406
40Abnormality of the axillary hair (HP:0100134)2.63361406
41Abnormality of the carotid arteries (HP:0005344)2.62828406
42Ectopic kidney (HP:0000086)2.59367191
43Sloping forehead (HP:0000340)2.58346922
44Duodenal stenosis (HP:0100867)2.57615806
45Small intestinal stenosis (HP:0012848)2.57615806
46Congenital ichthyosiform erythroderma (HP:0007431)2.51760617
47Abnormality of alanine metabolism (HP:0010916)2.50258209
48Hyperalaninemia (HP:0003348)2.50258209
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50258209
50Ependymoma (HP:0002888)2.49898693
51Exercise intolerance (HP:0003546)2.49884893
52Exertional dyspnea (HP:0002875)2.47236252
53Triphalangeal thumb (HP:0001199)2.46960630
54Patellar aplasia (HP:0006443)2.43544164
55Peripheral hypomyelination (HP:0007182)2.41024806
56Abnormality of midbrain morphology (HP:0002418)2.37288247
57Molar tooth sign on MRI (HP:0002419)2.37288247
58Asplenia (HP:0001746)2.34621804
59Stenosis of the external auditory canal (HP:0000402)2.33383806
60Hypoplasia of the pons (HP:0012110)2.33353443
61Absent radius (HP:0003974)2.32719130
62Aplasia/Hypoplasia of the patella (HP:0006498)2.32559917
63Morphological abnormality of the inner ear (HP:0011390)2.32011582
64Pallor (HP:0000980)2.31629053
65Myelodysplasia (HP:0002863)2.31617953
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.28228791
67Abnormal ciliary motility (HP:0012262)2.27261644
68Abnormal respiratory motile cilium morphology (HP:0005938)2.27170222
69Abnormal respiratory epithelium morphology (HP:0012253)2.27170222
70Abnormality of the pons (HP:0007361)2.26272368
71Absent forearm bone (HP:0003953)2.25905274
72Aplasia involving forearm bones (HP:0009822)2.25905274
73Increased serum lactate (HP:0002151)2.25575625
74Microvesicular hepatic steatosis (HP:0001414)2.25239378
75Glioma (HP:0009733)2.25145606
76Abnormality of the duodenum (HP:0002246)2.22696409
77Abnormality of renal resorption (HP:0011038)2.21745484
78CNS hypomyelination (HP:0003429)2.20712101
79Increased intramyocellular lipid droplets (HP:0012240)2.17491503
80Birth length less than 3rd percentile (HP:0003561)2.17363785
81Clubbing of toes (HP:0100760)2.16629541
82Respiratory failure (HP:0002878)2.16479371
83Pendular nystagmus (HP:0012043)2.14654354
84Abnormality of the corticospinal tract (HP:0002492)2.13964177
85Aplasia/Hypoplasia of the spleen (HP:0010451)2.13719411
86Pancytopenia (HP:0001876)2.13493561
87Short thumb (HP:0009778)2.12269509
88Duplicated collecting system (HP:0000081)2.10564544
89Volvulus (HP:0002580)2.10200873
90Astrocytoma (HP:0009592)2.10069836
91Abnormality of the astrocytes (HP:0100707)2.10069836
92Abnormality of the labia minora (HP:0012880)2.09983046
93Hypoplastic pelvis (HP:0008839)2.07595111
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06649931
95Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06649931
96Limb dystonia (HP:0002451)2.06351139
97Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06012267
98Type I transferrin isoform profile (HP:0003642)2.05019099
99Pancreatic cysts (HP:0001737)2.04635821
100Autoamputation (HP:0001218)2.03704675
101Hypothermia (HP:0002045)2.03553260
102Abnormal number of incisors (HP:0011064)2.02874455
103Supernumerary spleens (HP:0009799)2.01431412
104Multiple enchondromatosis (HP:0005701)2.00901371
105Adrenal hypoplasia (HP:0000835)1.99924229
106Cupped ear (HP:0000378)1.97575261
107Hepatic necrosis (HP:0002605)1.97383102
108Microretrognathia (HP:0000308)1.96968453
109External ophthalmoplegia (HP:0000544)1.96619591
110Abnormality of the septum pellucidum (HP:0007375)1.95221787
111Squamous cell carcinoma (HP:0002860)1.95036506
112Pancreatic fibrosis (HP:0100732)1.94496197
113Abnormal hair whorl (HP:0010721)1.94222597
114Absent/shortened dynein arms (HP:0200106)1.93927008
115Dynein arm defect of respiratory motile cilia (HP:0012255)1.93927008
116Abnormality of DNA repair (HP:0003254)1.93348692
117Medial flaring of the eyebrow (HP:0010747)1.93242223
118Respiratory difficulties (HP:0002880)1.92689294
119Cerebral edema (HP:0002181)1.92491115
120Abnormality of serum amino acid levels (HP:0003112)1.88146335
121Abnormal glycosylation (HP:0012345)1.87338817
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87338817
123Abnormal protein N-linked glycosylation (HP:0012347)1.87338817
124Abnormal protein glycosylation (HP:0012346)1.87338817
125Horseshoe kidney (HP:0000085)1.85942629
126Delusions (HP:0000746)1.85800784
127Aplasia/hypoplasia of the uterus (HP:0008684)1.85791388
128Abnormal lung lobation (HP:0002101)1.85536948
129Abnormality of placental membranes (HP:0011409)1.85419788
130Amniotic constriction ring (HP:0009775)1.85419788
131Embryonal renal neoplasm (HP:0011794)1.85074343
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83841167
133Gait imbalance (HP:0002141)1.83331960
134Nephroblastoma (Wilms tumor) (HP:0002667)1.82717417
135Vaginal atresia (HP:0000148)1.81872630
136Lactic acidosis (HP:0003128)1.81729699
137Abnormality of the renal collecting system (HP:0004742)1.81527232
138Anomalous pulmonary venous return (HP:0010772)1.81343180
139Absent septum pellucidum (HP:0001331)1.81024005
140Aplastic anemia (HP:0001915)1.80332914
141Genital tract atresia (HP:0001827)1.80066573
142Hyperglycinemia (HP:0002154)1.80020819
143Anteriorly placed anus (HP:0001545)1.78290583
144Abnormal pupillary function (HP:0007686)1.77950182
145Optic nerve coloboma (HP:0000588)1.77512550
146Abnormality of cochlea (HP:0000375)1.76869928
147Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76803741
148Cleft eyelid (HP:0000625)1.76790067
149Preaxial hand polydactyly (HP:0001177)1.76706104
150Abnormality of homocysteine metabolism (HP:0010919)1.76272987
151Homocystinuria (HP:0002156)1.76272987
152Abnormality of methionine metabolism (HP:0010901)1.76146906
153Aplasia of the musculature (HP:0100854)1.76012365
154Septo-optic dysplasia (HP:0100842)1.75785830
155Abnormal respiratory motile cilium physiology (HP:0012261)1.75646952
156Congenital primary aphakia (HP:0007707)1.75600164
157Progressive muscle weakness (HP:0003323)1.75254277
158Nasolacrimal duct obstruction (HP:0000579)1.73206206
159Atonic seizures (HP:0010819)1.73063027
160Partial agenesis of the corpus callosum (HP:0001338)1.71898974
161Alacrima (HP:0000522)1.71710817
162Increased nuchal translucency (HP:0010880)1.70443871
163Overfolded helix (HP:0000396)1.69778835
164Duplication of thumb phalanx (HP:0009942)1.69170559
165Rhabdomyosarcoma (HP:0002859)1.68892354
166Neoplasm of the colon (HP:0100273)1.68598945
167Megaloblastic anemia (HP:0001889)1.65889195
168Irregular epiphyses (HP:0010582)1.65787600
169Neoplasm of the adrenal cortex (HP:0100641)1.65668528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.85382923
2STK163.85224537
3BUB13.27987010
4VRK23.10843988
5STK392.74265537
6CASK2.39178679
7NEK12.38541314
8TNIK2.29148780
9WEE12.15207888
10VRK12.14022054
11SRPK12.07526355
12NME12.07452907
13OXSR12.01979027
14NUAK11.98257160
15MARK11.96012496
16TLK11.94430162
17IRAK21.92466797
18TAF11.91004440
19TRIM281.75139843
20PLK41.72264418
21PBK1.70989014
22ATR1.67332848
23BCR1.66497111
24NME21.61189973
25IRAK31.59723397
26NEK21.56757413
27TSSK61.55372786
28MST41.48220255
29CSNK1G31.45013851
30IRAK41.43883550
31CDC71.40309971
32MKNK11.38062269
33BMPR1B1.37226960
34BRSK11.35180808
35MAPK131.35005680
36PKN11.32934331
37MAPKAPK51.30215703
38CDK81.27819731
39FGR1.26424395
40MUSK1.25440577
41MAP4K21.24354040
42WNK31.24086486
43UHMK11.17552771
44IRAK11.16905771
45DYRK21.14466601
46PASK1.14157218
47CAMK2B1.11439378
48ARAF1.09014545
49MKNK21.07089298
50EIF2AK31.07019094
51PDK21.06620354
52CDK191.05822770
53EPHA41.03624151
54CSNK1G11.02652935
55ATM1.01287527
56FES1.00782023
57FRK0.97611089
58PLK30.96665419
59NEK60.94917000
60GRK70.93828621
61ZAK0.92080273
62EIF2AK10.91924185
63CLK10.91102495
64CSNK1A1L0.90274521
65GRK10.88317172
66ADRBK20.87326623
67PLK20.86771105
68NTRK30.85135270
69TTK0.83920045
70LIMK10.83452891
71BRAF0.81612042
72MAPK150.80887250
73INSRR0.79514250
74SMG10.78523996
75MAP2K70.78426112
76ROCK20.77927164
77AURKA0.77166196
78CSNK1G20.76446629
79TGFBR10.75697278
80STK40.74561913
81GRK50.74293221
82RPS6KA50.72998944
83EPHA20.72615588
84STK30.70062106
85BMPR20.70003605
86CDK40.69943192
87EEF2K0.68139674
88PLK10.67866587
89CAMK2D0.67196750
90CAMK2A0.66919594
91WNK40.66857728
92RPS6KA40.66372365
93AKT30.66116015
94CDK10.65558589
95CSNK2A20.63408304
96CDK20.63024410
97DAPK10.62250626
98MAP3K120.60746070
99BRD40.56702121
100ABL20.55402024
101CAMK2G0.54739189
102CSNK1E0.52772700
103CDK30.52042591
104RPS6KB20.51932111
105MELK0.51751496
106CDK120.49782626
107BCKDK0.49222101
108CSNK2A10.47813770
109CHEK20.47483194
110PRKDC0.47446212
111CDK140.47163214
112ALK0.46747369
113MAP3K40.46512306
114YES10.45376296
115ERBB40.43961074
116PAK10.43434924
117MAP3K80.43242373
118CDK70.43188878
119DYRK30.42684591
120CCNB10.42573382
121EIF2AK20.42304029
122TESK20.42015808
123CDK150.41541932
124MAP2K20.41083863
125CDK11A0.41083038
126STK38L0.40515622
127CDK180.39778767
128ADRBK10.39772443
129CDK90.39436846
130PRKCI0.39342519
131LATS10.38726411
132AURKB0.38718690
133NTRK10.38339846
134PRKACA0.37663556
135BRSK20.37559035
136CHEK10.37234553
137PRKCE0.35555761
138MYLK0.34429779
139ACVR1B0.33833851
140PIM10.33085878
141FLT30.32743118
142CAMK1D0.30901235
143STK100.30056155
144MST1R0.29354296
145MAP3K100.28227507
146MAPK140.25018748
147FGFR10.24450645
148AKT20.23728445

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.55485311
2Oxidative phosphorylation_Homo sapiens_hsa001904.31215249
3Proteasome_Homo sapiens_hsa030503.67266997
4Parkinsons disease_Homo sapiens_hsa050123.58513780
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.54734485
6RNA polymerase_Homo sapiens_hsa030203.43897541
7Alzheimers disease_Homo sapiens_hsa050102.82260041
8Huntingtons disease_Homo sapiens_hsa050162.76087019
9DNA replication_Homo sapiens_hsa030302.35800756
10Spliceosome_Homo sapiens_hsa030402.33053721
11Mismatch repair_Homo sapiens_hsa034302.31775146
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31149501
13Protein export_Homo sapiens_hsa030602.19491730
14Steroid biosynthesis_Homo sapiens_hsa001002.02615211
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99794480
16Selenocompound metabolism_Homo sapiens_hsa004501.93773022
17Homologous recombination_Homo sapiens_hsa034401.91954223
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91110921
19Pyrimidine metabolism_Homo sapiens_hsa002401.84629808
20Basal transcription factors_Homo sapiens_hsa030221.83218774
21Nucleotide excision repair_Homo sapiens_hsa034201.69178646
22Ether lipid metabolism_Homo sapiens_hsa005651.63002969
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.59910227
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58731444
25Non-homologous end-joining_Homo sapiens_hsa034501.54774219
26Fanconi anemia pathway_Homo sapiens_hsa034601.54036963
27Fatty acid elongation_Homo sapiens_hsa000621.51437764
28Cardiac muscle contraction_Homo sapiens_hsa042601.43307112
29Nicotine addiction_Homo sapiens_hsa050331.43295660
30RNA transport_Homo sapiens_hsa030131.40178215
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27864984
32Sulfur relay system_Homo sapiens_hsa041221.24584515
33Phototransduction_Homo sapiens_hsa047441.23620442
34Purine metabolism_Homo sapiens_hsa002301.20781324
35Serotonergic synapse_Homo sapiens_hsa047261.20500877
36Collecting duct acid secretion_Homo sapiens_hsa049661.09970904
37Pyruvate metabolism_Homo sapiens_hsa006201.08543105
38* RNA degradation_Homo sapiens_hsa030181.06376795
39Propanoate metabolism_Homo sapiens_hsa006401.01417102
40Biosynthesis of amino acids_Homo sapiens_hsa012301.00575325
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97675752
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97091259
43Linoleic acid metabolism_Homo sapiens_hsa005910.95687273
44Sphingolipid metabolism_Homo sapiens_hsa006000.94787172
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93641645
46Long-term depression_Homo sapiens_hsa047300.92292777
47Base excision repair_Homo sapiens_hsa034100.90796754
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88274171
49Arachidonic acid metabolism_Homo sapiens_hsa005900.85299632
50Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85271292
51Axon guidance_Homo sapiens_hsa043600.84073817
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82000608
53Glutathione metabolism_Homo sapiens_hsa004800.81362748
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79796479
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79481380
56Cell cycle_Homo sapiens_hsa041100.78808399
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73536008
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73456777
59Glutamatergic synapse_Homo sapiens_hsa047240.71550657
60Carbon metabolism_Homo sapiens_hsa012000.70674768
61Lysine degradation_Homo sapiens_hsa003100.68133009
62Vibrio cholerae infection_Homo sapiens_hsa051100.66816366
63Systemic lupus erythematosus_Homo sapiens_hsa053220.66573191
64Taste transduction_Homo sapiens_hsa047420.66564798
65Metabolic pathways_Homo sapiens_hsa011000.65501015
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61885485
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61430568
68Rheumatoid arthritis_Homo sapiens_hsa053230.60073194
69One carbon pool by folate_Homo sapiens_hsa006700.58837027
70mRNA surveillance pathway_Homo sapiens_hsa030150.58371194
71Autoimmune thyroid disease_Homo sapiens_hsa053200.56854106
72Alcoholism_Homo sapiens_hsa050340.56136336
73GABAergic synapse_Homo sapiens_hsa047270.55824072
74Epstein-Barr virus infection_Homo sapiens_hsa051690.55434690
75Butanoate metabolism_Homo sapiens_hsa006500.52766904
76N-Glycan biosynthesis_Homo sapiens_hsa005100.51011857
77Nitrogen metabolism_Homo sapiens_hsa009100.50019265
78Morphine addiction_Homo sapiens_hsa050320.48706245
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48415744
80Oocyte meiosis_Homo sapiens_hsa041140.47888790
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46798510
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46392802
83Amphetamine addiction_Homo sapiens_hsa050310.45303068
84Basal cell carcinoma_Homo sapiens_hsa052170.43155304
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43054671
86Vitamin B6 metabolism_Homo sapiens_hsa007500.42802600
87Arginine and proline metabolism_Homo sapiens_hsa003300.41606984
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.41209134
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40554737
90Tryptophan metabolism_Homo sapiens_hsa003800.36842503
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.35933250
92Cocaine addiction_Homo sapiens_hsa050300.34537445
93p53 signaling pathway_Homo sapiens_hsa041150.34489600
94Dopaminergic synapse_Homo sapiens_hsa047280.33983575
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33408835
96Graft-versus-host disease_Homo sapiens_hsa053320.32273398
97Tyrosine metabolism_Homo sapiens_hsa003500.31997603
98TGF-beta signaling pathway_Homo sapiens_hsa043500.31456950
99Hippo signaling pathway_Homo sapiens_hsa043900.30728851
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30355343
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29576551
102Gap junction_Homo sapiens_hsa045400.28488509
103Allograft rejection_Homo sapiens_hsa053300.27367154
104Asthma_Homo sapiens_hsa053100.26788937
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26782819
106Viral carcinogenesis_Homo sapiens_hsa052030.26406983
107African trypanosomiasis_Homo sapiens_hsa051430.25842303
108Long-term potentiation_Homo sapiens_hsa047200.25715106
109Folate biosynthesis_Homo sapiens_hsa007900.24826924
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24074675
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23648633
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23551401
113Hedgehog signaling pathway_Homo sapiens_hsa043400.22979354
114Peroxisome_Homo sapiens_hsa041460.21722863
115Phagosome_Homo sapiens_hsa041450.20927074
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.20677121
117Histidine metabolism_Homo sapiens_hsa003400.19746196
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.19574237
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19571782
120Fatty acid metabolism_Homo sapiens_hsa012120.19012783
121Pentose phosphate pathway_Homo sapiens_hsa000300.19003979
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18356058
123Regulation of autophagy_Homo sapiens_hsa041400.18343093
124Sulfur metabolism_Homo sapiens_hsa009200.17363376
125Vitamin digestion and absorption_Homo sapiens_hsa049770.17356710
126Wnt signaling pathway_Homo sapiens_hsa043100.15927760
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.15526193
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14814658
129Calcium signaling pathway_Homo sapiens_hsa040200.14410278
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13415279
131Circadian entrainment_Homo sapiens_hsa047130.13412568
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13223265
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13086897
134Tight junction_Homo sapiens_hsa045300.12967888
135Cholinergic synapse_Homo sapiens_hsa047250.12022576
136Renin secretion_Homo sapiens_hsa049240.10135313
137Synaptic vesicle cycle_Homo sapiens_hsa047210.09822024
138Ras signaling pathway_Homo sapiens_hsa040140.09275375
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09215261
140Caffeine metabolism_Homo sapiens_hsa002320.08493340
141MicroRNAs in cancer_Homo sapiens_hsa052060.07836176
142Thyroid cancer_Homo sapiens_hsa052160.07571518
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07483763
144HTLV-I infection_Homo sapiens_hsa051660.07362922

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