EXO5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.38668446
2DNA deamination (GO:0045006)4.88438612
3L-fucose catabolic process (GO:0042355)4.35374630
4fucose catabolic process (GO:0019317)4.35374630
5L-fucose metabolic process (GO:0042354)4.35374630
6viral transcription (GO:0019083)4.34573305
7DNA double-strand break processing (GO:0000729)4.25779157
8translational termination (GO:0006415)4.20952512
9DNA strand elongation involved in DNA replication (GO:0006271)4.13022948
10DNA replication initiation (GO:0006270)3.93825537
11DNA strand elongation (GO:0022616)3.92640505
12DNA unwinding involved in DNA replication (GO:0006268)3.92569952
13base-excision repair, AP site formation (GO:0006285)3.90316238
14telomere maintenance via semi-conservative replication (GO:0032201)3.86562430
15translational elongation (GO:0006414)3.82978409
16antigen processing and presentation via MHC class Ib (GO:0002475)3.79696450
17endosome to melanosome transport (GO:0035646)3.77593150
18endosome to pigment granule transport (GO:0043485)3.77593150
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.66727123
20ribosomal small subunit biogenesis (GO:0042274)3.63827015
21maturation of SSU-rRNA (GO:0030490)3.63326284
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.62738051
23translational initiation (GO:0006413)3.61542707
24purine nucleobase biosynthetic process (GO:0009113)3.60307782
25nucleobase biosynthetic process (GO:0046112)3.60068774
26formation of translation preinitiation complex (GO:0001731)3.59034945
27cotranslational protein targeting to membrane (GO:0006613)3.54412895
28protein targeting to ER (GO:0045047)3.53083268
29telomere maintenance via recombination (GO:0000722)3.51682313
30protein-cofactor linkage (GO:0018065)3.50175325
31CENP-A containing nucleosome assembly (GO:0034080)3.46961998
32regulation of cellular amino acid metabolic process (GO:0006521)3.44537576
33ubiquinone biosynthetic process (GO:0006744)3.43806272
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42417734
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42417734
36regulation of cilium movement (GO:0003352)3.40416547
37viral life cycle (GO:0019058)3.37270535
38DNA replication checkpoint (GO:0000076)3.35598383
39protein localization to endoplasmic reticulum (GO:0070972)3.33264527
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32244538
41protein deneddylation (GO:0000338)3.30975009
42mitotic recombination (GO:0006312)3.30941787
43ribonucleoprotein complex biogenesis (GO:0022613)3.30872840
44cellular protein complex disassembly (GO:0043624)3.30407860
45piRNA metabolic process (GO:0034587)3.29974994
46NADH dehydrogenase complex assembly (GO:0010257)3.29874141
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29874141
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.29874141
49DNA replication-independent nucleosome organization (GO:0034724)3.28933043
50DNA replication-independent nucleosome assembly (GO:0006336)3.28933043
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.28864536
52chromatin remodeling at centromere (GO:0031055)3.26942816
53ribosomal large subunit biogenesis (GO:0042273)3.26784759
54chaperone-mediated protein transport (GO:0072321)3.25450070
55ribosome biogenesis (GO:0042254)3.24781018
56pseudouridine synthesis (GO:0001522)3.23985184
57replication fork processing (GO:0031297)3.23369929
58kinetochore assembly (GO:0051382)3.18039146
59cullin deneddylation (GO:0010388)3.18024864
60establishment of integrated proviral latency (GO:0075713)3.17516312
61kinetochore organization (GO:0051383)3.15652942
62ubiquinone metabolic process (GO:0006743)3.14359928
63protein complex disassembly (GO:0043241)3.11759923
64proteasome assembly (GO:0043248)3.11365962
65protein complex biogenesis (GO:0070271)3.09453860
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08527647
67protein polyglutamylation (GO:0018095)3.06257796
68tRNA processing (GO:0008033)3.05850214
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05132053
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.03749811
71rRNA modification (GO:0000154)3.02210351
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01649289
73telomere maintenance via telomere lengthening (GO:0010833)3.01471463
74tryptophan catabolic process (GO:0006569)3.01068895
75indole-containing compound catabolic process (GO:0042436)3.01068895
76indolalkylamine catabolic process (GO:0046218)3.01068895
77nuclear-transcribed mRNA catabolic process (GO:0000956)2.99904918
78* DNA catabolic process, exonucleolytic (GO:0000738)2.99698456
79positive regulation of ligase activity (GO:0051351)2.99109892
80mitochondrial respiratory chain complex assembly (GO:0033108)2.99091106
81spliceosomal snRNP assembly (GO:0000387)2.98963075
82protein localization to kinetochore (GO:0034501)2.98550621
83negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.96883049
84macromolecular complex disassembly (GO:0032984)2.96181985
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96032031
86regulation of mitotic spindle checkpoint (GO:1903504)2.93523699
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93523699
88IMP biosynthetic process (GO:0006188)2.93167703
89rRNA processing (GO:0006364)2.92388844
90histone mRNA metabolic process (GO:0008334)2.91672704
91platelet dense granule organization (GO:0060155)2.91519023
92signal transduction involved in cell cycle checkpoint (GO:0072395)2.90285323
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89883499
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88755823
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.88755823
96metallo-sulfur cluster assembly (GO:0031163)2.87892435
97iron-sulfur cluster assembly (GO:0016226)2.87892435
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87805367
99DNA damage response, detection of DNA damage (GO:0042769)2.87433101
100mRNA catabolic process (GO:0006402)2.86293140
101tRNA metabolic process (GO:0006399)2.86174907
102maturation of 5.8S rRNA (GO:0000460)2.85947294
103respiratory chain complex IV assembly (GO:0008535)2.84616522
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83392209
105negative regulation of RNA splicing (GO:0033119)2.82947047
106rRNA metabolic process (GO:0016072)2.82428896
107RNA splicing, via transesterification reactions (GO:0000375)2.82257883
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80787769
109maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79802801
110mRNA splicing, via spliceosome (GO:0000398)2.79241016
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.79241016
112termination of RNA polymerase II transcription (GO:0006369)2.79073815
113mitotic nuclear envelope disassembly (GO:0007077)2.77308599
114RNA catabolic process (GO:0006401)2.76991304
115mismatch repair (GO:0006298)2.76115514
116pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76021242
117transcription-coupled nucleotide-excision repair (GO:0006283)2.75866897
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.75842328
119folic acid-containing compound biosynthetic process (GO:0009396)2.75517646
120DNA replication-dependent nucleosome assembly (GO:0006335)2.75051279
121DNA replication-dependent nucleosome organization (GO:0034723)2.75051279
122exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74354693
123regulation of double-strand break repair via homologous recombination (GO:0010569)2.72981413
124terpenoid biosynthetic process (GO:0016114)2.71551863
125viral mRNA export from host cell nucleus (GO:0046784)2.71463756
126negative regulation of ligase activity (GO:0051352)2.69586933
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69586933
128translation (GO:0006412)2.69002759
129mitotic sister chromatid segregation (GO:0000070)2.68900027
130regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.68461580
131tryptophan metabolic process (GO:0006568)2.68427919
132protein localization to chromosome, centromeric region (GO:0071459)2.67816788
133acrosome reaction (GO:0007340)2.67424766
134rRNA methylation (GO:0031167)2.66842075
135regulation of ubiquitin-protein transferase activity (GO:0051438)2.66270788
136histone exchange (GO:0043486)2.65029301
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64355224
1387-methylguanosine mRNA capping (GO:0006370)2.64057948
139fucosylation (GO:0036065)2.63050766
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.62504008
141protein neddylation (GO:0045116)2.61931614
142IMP metabolic process (GO:0046040)2.61642307
143somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61462951
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.61462951
145spliceosomal complex assembly (GO:0000245)2.61063379
146histone H2A acetylation (GO:0043968)2.60737109
147RNA capping (GO:0036260)2.60592973
1487-methylguanosine RNA capping (GO:0009452)2.60592973
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60439023
150centriole replication (GO:0007099)2.60266523
151regulation of ligase activity (GO:0051340)2.60235915
152quinone biosynthetic process (GO:1901663)2.60091503
153recombinational repair (GO:0000725)2.60061564
154ribosome assembly (GO:0042255)2.59412097
155peptidyl-histidine modification (GO:0018202)2.59331015
156multicellular organism reproduction (GO:0032504)2.59192311
157DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.58988816
158mitotic metaphase plate congression (GO:0007080)2.56709359
159double-strand break repair via homologous recombination (GO:0000724)2.56518878
160signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55649986
161intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55649986
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.54888329
163negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.54749069
164transcription elongation from RNA polymerase III promoter (GO:0006385)2.54702385
165termination of RNA polymerase III transcription (GO:0006386)2.54702385
166signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54209921
167signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54209921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.42611419
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.04571710
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.61774723
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.51046491
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.17410665
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.15719213
7ZNF274_21170338_ChIP-Seq_K562_Hela3.11391922
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03593629
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.97313411
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89160866
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.87984682
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.84462088
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78973908
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76048697
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73045777
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73027257
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67628826
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.64957536
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56655153
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45698137
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.40901992
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36511672
23VDR_23849224_ChIP-Seq_CD4+_Human2.36170784
24XRN2_22483619_ChIP-Seq_HELA_Human2.33103472
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.22550379
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17741080
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.10733615
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.10572948
29IGF1R_20145208_ChIP-Seq_DFB_Human2.09036909
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02257534
31MYC_22102868_ChIP-Seq_BL_Human2.01935184
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01834462
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01647052
34IRF1_19129219_ChIP-ChIP_H3396_Human2.01014830
35VDR_22108803_ChIP-Seq_LS180_Human1.99189006
36GABP_19822575_ChIP-Seq_HepG2_Human1.98919849
37CIITA_25753668_ChIP-Seq_RAJI_Human1.97524993
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94380684
39FOXP3_21729870_ChIP-Seq_TREG_Human1.90740968
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90173846
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89517061
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.88936460
43TTF2_22483619_ChIP-Seq_HELA_Human1.84891511
44DCP1A_22483619_ChIP-Seq_HELA_Human1.80435770
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80182391
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75480054
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74721908
48ELK1_19687146_ChIP-ChIP_HELA_Human1.74050553
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70240926
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70222521
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69382906
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.67797312
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67197329
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66959026
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66459890
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65357664
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61074920
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59495561
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58546061
60EWS_26573619_Chip-Seq_HEK293_Human1.57337913
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56399248
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.54772360
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.54600292
64VDR_21846776_ChIP-Seq_THP-1_Human1.54014066
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.51121767
66SPI1_23547873_ChIP-Seq_NB4_Human1.50333539
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48861192
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47530017
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.47330072
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43892237
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.39921733
72AR_21909140_ChIP-Seq_LNCAP_Human1.39849073
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38005743
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.37399597
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36904802
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36349388
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34651898
78FUS_26573619_Chip-Seq_HEK293_Human1.32190022
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31322281
80SCL_19346495_ChIP-Seq_HPC-7_Human1.27024149
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26911919
82TFEB_21752829_ChIP-Seq_HELA_Human1.25624814
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24662141
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22564913
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21421411
86KDM5A_27292631_Chip-Seq_BREAST_Human1.19298871
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.17737493
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17532019
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.16543833
90TP53_22573176_ChIP-Seq_HFKS_Human1.15821634
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13972695
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13494180
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12357635
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11437652
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10790046
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07015442
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06173474
98EZH2_22144423_ChIP-Seq_EOC_Human1.05838593
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04134204
100ER_23166858_ChIP-Seq_MCF-7_Human1.03801066
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03072791
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02842402
103P300_19829295_ChIP-Seq_ESCs_Human1.01746086
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01680508
105MYC_18940864_ChIP-ChIP_HL60_Human1.01479858
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00997658
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00789872
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98556318
109MYB_26560356_Chip-Seq_TH2_Human0.96032050
110RUNX1_22412390_ChIP-Seq_EML_Mouse0.95541898
111ELK1_22589737_ChIP-Seq_MCF10A_Human0.95419509
112BP1_19119308_ChIP-ChIP_Hs578T_Human0.95205684
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94809400
114FOXA1_25329375_ChIP-Seq_VCAP_Human0.93165879
115FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93165879
116PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92451654
117UTX_26944678_Chip-Seq_JUKART_Human0.92271903
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91056299
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90944938
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90801144
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90409090
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90365477
123CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89441780
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88849721
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88537041
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88237105
127GBX2_23144817_ChIP-Seq_PC3_Human0.87434862
128NCOR_22424771_ChIP-Seq_293T_Human0.86342042
129GATA6_21074721_ChIP-Seq_CACO-2_Human0.85820666
130DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85333364
131NANOG_20526341_ChIP-Seq_ESCs_Human0.84886064
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84604337
133PHF8_20622853_ChIP-Seq_HELA_Human0.84209166
134CBP_20019798_ChIP-Seq_JUKART_Human0.84041455
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84041455
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83172827
137GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82567123
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82237043
139ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82110402
140RBPJ_21746931_ChIP-Seq_IB4_Human0.81189944
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78341399
142GATA3_26560356_Chip-Seq_TH2_Human0.78276773
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77199848
144FOXH1_21741376_ChIP-Seq_EPCs_Human0.76726387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.60385081
2MP0010094_abnormal_chromosome_stability3.57676186
3MP0003077_abnormal_cell_cycle3.37006516
4MP0004957_abnormal_blastocyst_morpholog3.24979697
5MP0002396_abnormal_hematopoietic_system3.17543286
6MP0003111_abnormal_nucleus_morphology3.15795114
7MP0008058_abnormal_DNA_repair2.85014385
8MP0008877_abnormal_DNA_methylation2.84206500
9MP0008057_abnormal_DNA_replication2.75679602
10MP0008007_abnormal_cellular_replicative2.71653916
11MP0005394_taste/olfaction_phenotype2.54321807
12MP0005499_abnormal_olfactory_system2.54321807
13MP0001835_abnormal_antigen_presentation2.34423900
14MP0003763_abnormal_thymus_physiology2.24560057
15MP0001529_abnormal_vocalization2.18442912
16MP0000490_abnormal_crypts_of2.16821930
17MP0004808_abnormal_hematopoietic_stem2.16703074
18MP0010352_gastrointestinal_tract_polyps2.13913247
19MP0008875_abnormal_xenobiotic_pharmacok2.12435057
20MP0001545_abnormal_hematopoietic_system2.05069785
21MP0005397_hematopoietic_system_phenotyp2.05069785
22MP0003436_decreased_susceptibility_to2.00674051
23MP0006072_abnormal_retinal_apoptosis1.99952883
24MP0009333_abnormal_splenocyte_physiolog1.95640245
25MP0005671_abnormal_response_to1.94760826
26MP0008932_abnormal_embryonic_tissue1.86140089
27MP0002398_abnormal_bone_marrow1.85960425
28MP0003786_premature_aging1.82114638
29MP0006035_abnormal_mitochondrial_morpho1.81167553
30MP0000350_abnormal_cell_proliferation1.79563987
31MP0006054_spinal_hemorrhage1.76390814
32MP0003806_abnormal_nucleotide_metabolis1.72061297
33MP0006036_abnormal_mitochondrial_physio1.68327929
34MP0003136_yellow_coat_color1.63401193
35MP0001730_embryonic_growth_arrest1.60918518
36MP0005084_abnormal_gallbladder_morpholo1.59750418
37MP0000685_abnormal_immune_system1.59155303
38MP0001800_abnormal_humoral_immune1.58875360
39MP0001905_abnormal_dopamine_level1.58832449
40MP0002160_abnormal_reproductive_system1.55295070
41MP0002722_abnormal_immune_system1.53214697
42MP0001929_abnormal_gametogenesis1.53212610
43MP0000465_gastrointestinal_hemorrhage1.52614480
44MP0009785_altered_susceptibility_to1.49872990
45MP0000703_abnormal_thymus_morphology1.49017549
46MP0000313_abnormal_cell_death1.48719715
47MP0000689_abnormal_spleen_morphology1.47773167
48MP0002019_abnormal_tumor_incidence1.47561584
49MP0009046_muscle_twitch1.46028136
50MP0002452_abnormal_antigen_presenting1.45401287
51MP0002420_abnormal_adaptive_immunity1.45127857
52MP0001984_abnormal_olfaction1.44434830
53MP0005464_abnormal_platelet_physiology1.44251601
54MP0001819_abnormal_immune_cell1.43084790
55MP0005000_abnormal_immune_tolerance1.43009207
56MP0005410_abnormal_fertilization1.41914911
57MP0005646_abnormal_pituitary_gland1.40194134
58MP0000716_abnormal_immune_system1.40067451
59MP0002429_abnormal_blood_cell1.39955830
60MP0010030_abnormal_orbit_morphology1.39525890
61MP0005389_reproductive_system_phenotype1.39373228
62MP0005551_abnormal_eye_electrophysiolog1.38346779
63MP0010307_abnormal_tumor_latency1.36242285
64MP0005253_abnormal_eye_physiology1.34678489
65MP0002837_dystrophic_cardiac_calcinosis1.34213625
66MP0001986_abnormal_taste_sensitivity1.33602303
67MP0008995_early_reproductive_senescence1.33487526
68MP0005645_abnormal_hypothalamus_physiol1.32020941
69MP0009697_abnormal_copulation1.30718977
70MP0002723_abnormal_immune_serum1.29301075
71MP0002095_abnormal_skin_pigmentation1.28656382
72MP0001968_abnormal_touch/_nociception1.27210369
73MP0002405_respiratory_system_inflammati1.25935783
74MP0000427_abnormal_hair_cycle1.25820742
75MP0001764_abnormal_homeostasis1.25268178
76MP0002653_abnormal_ependyma_morphology1.24539779
77MP0005025_abnormal_response_to1.24261024
78MP0010155_abnormal_intestine_physiology1.21526612
79MP0002876_abnormal_thyroid_physiology1.18300511
80MP0000569_abnormal_digit_pigmentation1.17517520
81MP0002736_abnormal_nociception_after1.15660568
82MP0001919_abnormal_reproductive_system1.14193461
83MP0005174_abnormal_tail_pigmentation1.13397174
84MP0009278_abnormal_bone_marrow1.11344660
85MP0003698_abnormal_male_reproductive1.09027308
86MP0003718_maternal_effect1.08789276
87MP0002132_abnormal_respiratory_system1.08551552
88MP0002080_prenatal_lethality1.07902811
89MP0003567_abnormal_fetal_cardiomyocyte1.06336133
90MP0001697_abnormal_embryo_size1.05886401
91MP0006276_abnormal_autonomic_nervous1.05688676
92MP0003011_delayed_dark_adaptation1.05285415
93MP0008789_abnormal_olfactory_epithelium1.05252462
94MP0000653_abnormal_sex_gland1.05094333
95MP0000858_altered_metastatic_potential1.04902590
96MP0003221_abnormal_cardiomyocyte_apopto1.03892317
97MP0008872_abnormal_physiological_respon1.03295283
98MP0006292_abnormal_olfactory_placode1.03269897
99MP0002148_abnormal_hypersensitivity_rea1.01771663
100MP0003195_calcinosis1.01042558
101MP0002233_abnormal_nose_morphology0.99526021
102MP0003123_paternal_imprinting0.99401445
103MP0001145_abnormal_male_reproductive0.98401802
104MP0000049_abnormal_middle_ear0.98105882
105MP0005360_urolithiasis0.96147821
106MP0005075_abnormal_melanosome_morpholog0.95621439
107MP0001873_stomach_inflammation0.94119231
108MP0001119_abnormal_female_reproductive0.94046431
109MP0000372_irregular_coat_pigmentation0.93767351
110MP0003183_abnormal_peptide_metabolism0.92690279
111MP0003121_genomic_imprinting0.92217098
112MP0009764_decreased_sensitivity_to0.91906797
113MP0004742_abnormal_vestibular_system0.91458223
114MP0000631_abnormal_neuroendocrine_gland0.89972583
115MP0002163_abnormal_gland_morphology0.89829832
116MP0002085_abnormal_embryonic_tissue0.88050934
117MP0005380_embryogenesis_phenotype0.87845303
118MP0001672_abnormal_embryogenesis/_devel0.87845303
119MP0002102_abnormal_ear_morphology0.87586170
120MP0002075_abnormal_coat/hair_pigmentati0.87579651
121MP0004142_abnormal_muscle_tone0.87251585
122MP0002938_white_spotting0.87098955
123MP0005395_other_phenotype0.86398035
124MP0003890_abnormal_embryonic-extraembry0.85711708
125MP0000358_abnormal_cell_content/0.85576028
126MP0002210_abnormal_sex_determination0.85513040
127MP0002419_abnormal_innate_immunity0.85377596
128MP0002084_abnormal_developmental_patter0.84836750
129MP0005387_immune_system_phenotype0.84833659
130MP0001790_abnormal_immune_system0.84833659
131MP0001853_heart_inflammation0.84339369
132MP0003943_abnormal_hepatobiliary_system0.82241354
133MP0001845_abnormal_inflammatory_respons0.81644840
134MP0008260_abnormal_autophagy0.79554814
135MP0000371_diluted_coat_color0.77232538
136MP0002067_abnormal_sensory_capabilities0.77146877
137MP0005195_abnormal_posterior_eye0.75651077
138MP0004197_abnormal_fetal_growth/weight/0.75643986
139MP0001293_anophthalmia0.74977435
140MP0003186_abnormal_redox_activity0.74627831
141MP0000015_abnormal_ear_pigmentation0.74390458
142MP0004215_abnormal_myocardial_fiber0.74140815
143MP0000477_abnormal_intestine_morphology0.73496985
144MP0003315_abnormal_perineum_morphology0.73382030
145MP0000647_abnormal_sebaceous_gland0.73299581
146MP0004133_heterotaxia0.73201872
147MP0001270_distended_abdomen0.73086724
148MP0002638_abnormal_pupillary_reflex0.72574758
149MP0002138_abnormal_hepatobiliary_system0.71074839
150MP0005076_abnormal_cell_differentiation0.70920792
151MP0002272_abnormal_nervous_system0.69691221
152MP0005379_endocrine/exocrine_gland_phen0.69668267
153MP0003984_embryonic_growth_retardation0.68646872
154MP0001186_pigmentation_phenotype0.68120250
155MP0002088_abnormal_embryonic_growth/wei0.67942093
156MP0002735_abnormal_chemical_nociception0.67149351
157MP0002933_joint_inflammation0.66766273
158MP0002161_abnormal_fertility/fecundity0.66272297
159MP0002086_abnormal_extraembryonic_tissu0.66164888
160MP0002752_abnormal_somatic_nervous0.62293437
161MP0005647_abnormal_sex_gland0.61755146

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.96527195
2Reticulocytopenia (HP:0001896)4.54449690
3Aplastic anemia (HP:0001915)4.23704261
4Abnormality of cells of the erythroid lineage (HP:0012130)3.79124889
5Colon cancer (HP:0003003)3.70953833
6Molar tooth sign on MRI (HP:0002419)3.69949762
7Abnormality of midbrain morphology (HP:0002418)3.69949762
8Pancreatic cysts (HP:0001737)3.62362049
9Pancreatic fibrosis (HP:0100732)3.61735740
10Bile duct proliferation (HP:0001408)3.51003432
11Abnormal biliary tract physiology (HP:0012439)3.51003432
12IgM deficiency (HP:0002850)3.48783582
13Abnormal number of erythroid precursors (HP:0012131)3.44514613
14Acute necrotizing encephalopathy (HP:0006965)3.41208125
15Optic nerve coloboma (HP:0000588)3.40015876
16Patellar aplasia (HP:0006443)3.35531774
17Mitochondrial inheritance (HP:0001427)3.31453011
18Chromsome breakage (HP:0040012)3.19104633
19Increased CSF lactate (HP:0002490)3.10088137
20Aplasia/Hypoplasia of the patella (HP:0006498)3.09909682
21Abnormal mitochondria in muscle tissue (HP:0008316)3.02934841
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02932740
233-Methylglutaconic aciduria (HP:0003535)2.91835485
24Acute encephalopathy (HP:0006846)2.89723896
25Thrombocytosis (HP:0001894)2.86388155
26Oral leukoplakia (HP:0002745)2.86044507
27Progressive macrocephaly (HP:0004481)2.85823555
28Myelodysplasia (HP:0002863)2.77361479
29Type II lissencephaly (HP:0007260)2.76950457
30Nephronophthisis (HP:0000090)2.76504032
31Pallor (HP:0000980)2.75089026
32Microretrognathia (HP:0000308)2.72908670
33Breast hypoplasia (HP:0003187)2.70074294
34Abolished electroretinogram (ERG) (HP:0000550)2.66021153
35Chronic otitis media (HP:0000389)2.65048148
36Hepatocellular necrosis (HP:0001404)2.64920058
37Hepatic necrosis (HP:0002605)2.62774874
38Renal cortical cysts (HP:0000803)2.60671023
39Slender long bone (HP:0003100)2.59863919
40Chronic hepatic failure (HP:0100626)2.51316247
41Abnormal protein glycosylation (HP:0012346)2.51225243
42Abnormal glycosylation (HP:0012345)2.51225243
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51225243
44Abnormal protein N-linked glycosylation (HP:0012347)2.51225243
45Medulloblastoma (HP:0002885)2.44966849
46Abnormality of lateral ventricle (HP:0030047)2.44600273
47Pendular nystagmus (HP:0012043)2.44370977
48Increased serum lactate (HP:0002151)2.42307251
49Macrocytic anemia (HP:0001972)2.41668637
50Bone marrow hypocellularity (HP:0005528)2.40527708
51Abnormality of the renal cortex (HP:0011035)2.40394257
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40227673
53Progressive inability to walk (HP:0002505)2.38845951
54Progressive microcephaly (HP:0000253)2.37615421
55Premature graying of hair (HP:0002216)2.35154562
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.34287686
57Elevated erythrocyte sedimentation rate (HP:0003565)2.32762627
58Lymphoma (HP:0002665)2.32016023
59Type I transferrin isoform profile (HP:0003642)2.31772555
60Abnormality of the renal medulla (HP:0100957)2.31572197
61Inability to walk (HP:0002540)2.31531124
62Degeneration of anterior horn cells (HP:0002398)2.29096352
63Abnormality of the anterior horn cell (HP:0006802)2.29096352
64Poor head control (HP:0002421)2.28844361
65Abnormality of the preputium (HP:0100587)2.27570879
66Cerebellar dysplasia (HP:0007033)2.27229257
67Meckel diverticulum (HP:0002245)2.25677947
68Abnormality of cochlea (HP:0000375)2.25564733
69Abnormality of the labia minora (HP:0012880)2.24527885
70Agnosia (HP:0010524)2.23891038
71Petechiae (HP:0000967)2.23581098
72Microvesicular hepatic steatosis (HP:0001414)2.23133377
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22953623
74Neoplasm of the pancreas (HP:0002894)2.21221842
75Abnormality of DNA repair (HP:0003254)2.20701912
76Abnormality of the ileum (HP:0001549)2.19827206
77Poikiloderma (HP:0001029)2.18279031
78Retinal dysplasia (HP:0007973)2.18258828
79Abnormality of chromosome stability (HP:0003220)2.17394565
80Acute myeloid leukemia (HP:0004808)2.15732190
81Abnormality of the intervertebral disk (HP:0005108)2.14500747
82Lipid accumulation in hepatocytes (HP:0006561)2.14409276
83Optic disc pallor (HP:0000543)2.13664181
84Rough bone trabeculation (HP:0100670)2.13218917
85Medial flaring of the eyebrow (HP:0010747)2.12300181
86Hypoplasia of the pons (HP:0012110)2.11661936
87Lactic acidosis (HP:0003128)2.11411757
88Selective tooth agenesis (HP:0001592)2.10704338
89Carpal bone hypoplasia (HP:0001498)2.10179635
90Cutaneous melanoma (HP:0012056)2.10071380
91Opisthotonus (HP:0002179)2.09161342
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.08674777
93Pulmonary fibrosis (HP:0002206)2.08640006
94Aplasia/hypoplasia of the uterus (HP:0008684)2.06772091
95Amaurosis fugax (HP:0100576)2.06082015
96Sclerocornea (HP:0000647)2.06081024
97Absent thumb (HP:0009777)2.03854352
98Sloping forehead (HP:0000340)2.01529410
99Pancytopenia (HP:0001876)2.00805931
100Abnormal rod and cone electroretinograms (HP:0008323)1.99961312
101Myositis (HP:0100614)1.99247496
102Ependymoma (HP:0002888)1.98976889
103Cerebral edema (HP:0002181)1.98784345
104Recurrent bronchitis (HP:0002837)1.98599070
105Entropion (HP:0000621)1.97929270
106Abnormality of the prostate (HP:0008775)1.97462058
107Anencephaly (HP:0002323)1.96919148
108Nasal polyposis (HP:0100582)1.96904040
109Small intestinal stenosis (HP:0012848)1.95817103
110Duodenal stenosis (HP:0100867)1.95817103
111Tracheoesophageal fistula (HP:0002575)1.95132336
112Cellular immunodeficiency (HP:0005374)1.95111908
113Atresia of the external auditory canal (HP:0000413)1.94819858
114Abnormality of cells of the lymphoid lineage (HP:0012140)1.94123315
115Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93088276
116Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93088276
117Tubulointerstitial nephritis (HP:0001970)1.93011831
118Lymphopenia (HP:0001888)1.92773123
119Abnormality of the pons (HP:0007361)1.92344606
120Congenital stationary night blindness (HP:0007642)1.91685823
121Depressed nasal ridge (HP:0000457)1.91092721
122Abnormality of the renal collecting system (HP:0004742)1.90926617
123Type 2 muscle fiber atrophy (HP:0003554)1.90260742
124Ectopic kidney (HP:0000086)1.90052705
125Broad face (HP:0000283)1.88725438
126Recurrent abscess formation (HP:0002722)1.88313433
127Attenuation of retinal blood vessels (HP:0007843)1.86633109
128Cystic liver disease (HP:0006706)1.86448655
129Abnormal respiratory epithelium morphology (HP:0012253)1.86309942
130Abnormal respiratory motile cilium morphology (HP:0005938)1.86309942
131Congenital hepatic fibrosis (HP:0002612)1.86153899
132Muscle fiber atrophy (HP:0100295)1.84368751
133CNS hypomyelination (HP:0003429)1.83964521
134Prolonged bleeding time (HP:0003010)1.82957183
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.82715865
136Wrist flexion contracture (HP:0001239)1.82614049
137Cellulitis (HP:0100658)1.82145456
138Reduced antithrombin III activity (HP:0001976)1.82013914
139Hyperacusis (HP:0010780)1.80525068
140Abnormal number of incisors (HP:0011064)1.79943525
141Basal cell carcinoma (HP:0002671)1.79849488
142Increased nuchal translucency (HP:0010880)1.79646681
143Clubbing of toes (HP:0100760)1.78177565
14411 pairs of ribs (HP:0000878)1.76963395
145Postaxial foot polydactyly (HP:0001830)1.74872258
146Duplicated collecting system (HP:0000081)1.74326790
147Increased hepatocellular lipid droplets (HP:0006565)1.74110296
148IgG deficiency (HP:0004315)1.73007947
149Recurrent bacterial skin infections (HP:0005406)1.72608332
150Oligohydramnios (HP:0001562)1.72430434
151Optic nerve hypoplasia (HP:0000609)1.71411052
152Abnormality of T cell physiology (HP:0011840)1.70752317
153Pachygyria (HP:0001302)1.70511718
154Abnormality of the carotid arteries (HP:0005344)1.70508033
155Irregular epiphyses (HP:0010582)1.70240999
156Respiratory failure (HP:0002878)1.69947263
157True hermaphroditism (HP:0010459)1.68839740
158Mediastinal lymphadenopathy (HP:0100721)1.68589787
159Proximal placement of thumb (HP:0009623)1.66316771
160Atrophy/Degeneration involving motor neurons (HP:0007373)1.65581674
161Acute lymphatic leukemia (HP:0006721)1.65569144
162Deviation of the thumb (HP:0009603)1.64424599
163Abnormality of the nasal mucosa (HP:0000433)1.64260795
164Abnormal lung lobation (HP:0002101)1.64042709
165Abnormality of the duodenum (HP:0002246)1.63691038
166Abnormality of alanine metabolism (HP:0010916)1.60841801
167Hyperalaninemia (HP:0003348)1.60841801
168Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.60841801
169Panhypogammaglobulinemia (HP:0003139)1.58540476
170Recurrent viral infections (HP:0004429)1.57172319
171Horseshoe kidney (HP:0000085)1.57123408
172Aseptic necrosis (HP:0010885)1.56923402
173Neoplasm of the colon (HP:0100273)1.54584860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.48969372
2PINK13.40860995
3ZAK3.24963076
4ACVR1B3.14762668
5STK38L2.99048394
6FRK2.78198010
7TGFBR12.75878839
8ADRBK22.69032177
9WNK32.59193521
10STK162.50555434
11MAP4K22.50465703
12WEE12.49208929
13PIM22.38206912
14CDC72.25142874
15NME22.25019898
16EIF2AK12.09849133
17MAP2K72.02339151
18EEF2K1.96487142
19MAP4K11.95337254
20GRK11.94509642
21DYRK31.93259258
22CDK81.87912558
23BTK1.87059292
24NEK21.80427033
25PLK41.77829199
26SRPK11.71492910
27RPS6KB21.70379312
28PASK1.67404326
29MKNK11.67125916
30NUAK11.61991305
31VRK21.61446493
32DYRK21.61235655
33BMPR1B1.57720078
34RPS6KA41.57321878
35VRK11.54221557
36BCKDK1.51973238
37ATR1.50886433
38TLK11.45951533
39SIK31.45382195
40TSSK61.42393308
41MAP3K41.41768536
42KIT1.41256081
43CSNK1A1L1.40272317
44MARK31.38549998
45TEC1.31707179
46CDK71.31440619
47CSNK1G11.31116775
48SCYL21.30856785
49FLT31.28138481
50CSNK1G21.24824459
51TESK21.23997565
52AURKB1.22543209
53STK381.21816693
54PLK11.19202677
55CDK191.19112989
56MAPKAPK31.18530253
57ITK1.18063050
58NEK11.08340000
59LRRK21.06526698
60MAP3K121.04400174
61PBK1.02896077
62TTK1.02473212
63BLK1.01093559
64MAP3K111.00497968
65ILK0.97209711
66NME10.96373010
67IRAK40.96010741
68YES10.95933919
69TAOK30.94656037
70FGFR40.94377665
71AURKA0.91084825
72MST40.90670916
73ZAP700.90510880
74SYK0.90412018
75CAMKK20.89979145
76TIE10.88522852
77FGFR20.87789362
78STK100.86931857
79KDR0.86855493
80CDK40.86802793
81CHEK20.86593187
82PIM10.86207417
83MKNK20.85910810
84CSF1R0.85255258
85RPS6KA50.83284198
86INSRR0.82589699
87PAK40.82469213
88BRAF0.81903248
89CLK10.81563291
90MAP3K80.81093362
91ATM0.80391049
92CCNB10.78901500
93TAOK20.78795948
94EIF2AK30.77278958
95TRIB30.77058906
96MAPK130.76909324
97TBK10.75885296
98PLK20.75567524
99PLK30.74381431
100STK40.71807152
101SIK20.71665949
102LYN0.71110440
103TRIM280.68212132
104IKBKB0.67718943
105MAP3K60.64976228
106MELK0.64318941
107TNIK0.63934802
108CHEK10.63518306
109CSNK1G30.63361171
110TXK0.63110079
111MAP3K50.63009575
112MAP2K30.62374971
113MATK0.61377826
114PTK2B0.61303909
115TYK20.59732428
116IKBKE0.56949197
117PKN20.55488772
118GRK60.55223240
119BRSK20.54162693
120JAK30.51395148
121CSNK2A10.51234041
122CDK20.50558953
123NLK0.50464703
124PDGFRA0.50413186
125EIF2AK20.50310124
126CSNK1A10.50007804
127CDK60.49388961
128PRKCI0.48506072
129IRAK20.48208954
130CHUK0.47957584
131PRKCQ0.47094887
132WNK40.46698936
133LCK0.46323647
134ADRBK10.46196361
135DYRK1B0.45882244
136BRSK10.45768257
137BCR0.45506522
138CDK90.45503711
139CSNK1D0.44493488
140ABL20.44225959
141TESK10.43642689
142FGFR30.43144650
143CDK30.42083207
144CASK0.39667689
145GRK70.37174887
146CSNK2A20.34846536
147PRKCE0.33718910
148PRKCG0.32438908
149DAPK10.31964812
150PKN10.30846890

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46548293
2Ribosome_Homo sapiens_hsa030103.62774559
3Mismatch repair_Homo sapiens_hsa034303.53744752
4Spliceosome_Homo sapiens_hsa030403.24493003
5Base excision repair_Homo sapiens_hsa034103.02867057
6RNA polymerase_Homo sapiens_hsa030202.97367736
7Proteasome_Homo sapiens_hsa030502.90764136
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87172474
9Nucleotide excision repair_Homo sapiens_hsa034202.53128461
10Cell cycle_Homo sapiens_hsa041102.49909803
11Homologous recombination_Homo sapiens_hsa034402.45704892
12RNA transport_Homo sapiens_hsa030132.42387489
13Pyrimidine metabolism_Homo sapiens_hsa002402.36194977
14Oxidative phosphorylation_Homo sapiens_hsa001902.19416609
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08258058
16Basal transcription factors_Homo sapiens_hsa030222.06390873
17Parkinsons disease_Homo sapiens_hsa050122.03001619
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95403594
19Fanconi anemia pathway_Homo sapiens_hsa034601.88438914
20Non-homologous end-joining_Homo sapiens_hsa034501.87784941
21RNA degradation_Homo sapiens_hsa030181.78563144
22Phototransduction_Homo sapiens_hsa047441.72703612
23p53 signaling pathway_Homo sapiens_hsa041151.72579984
24One carbon pool by folate_Homo sapiens_hsa006701.67996202
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67119437
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66486436
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.64361809
28Fatty acid elongation_Homo sapiens_hsa000621.63927265
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57505650
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49390553
31mRNA surveillance pathway_Homo sapiens_hsa030151.45513336
32Huntingtons disease_Homo sapiens_hsa050161.44139127
33Butanoate metabolism_Homo sapiens_hsa006501.41133589
34Epstein-Barr virus infection_Homo sapiens_hsa051691.32914550
35Purine metabolism_Homo sapiens_hsa002301.31377719
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30913000
37Primary immunodeficiency_Homo sapiens_hsa053401.29716610
38Shigellosis_Homo sapiens_hsa051311.29567057
39Herpes simplex infection_Homo sapiens_hsa051681.27664217
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23534318
41Propanoate metabolism_Homo sapiens_hsa006401.15957403
42Caffeine metabolism_Homo sapiens_hsa002321.14970642
43Antigen processing and presentation_Homo sapiens_hsa046121.09872585
44Alzheimers disease_Homo sapiens_hsa050101.07742826
45Peroxisome_Homo sapiens_hsa041461.03344792
46Legionellosis_Homo sapiens_hsa051341.03068294
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.01012172
48Measles_Homo sapiens_hsa051620.99232228
49Sulfur metabolism_Homo sapiens_hsa009200.97007677
50N-Glycan biosynthesis_Homo sapiens_hsa005100.96350381
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95991768
52Tryptophan metabolism_Homo sapiens_hsa003800.94377293
53Protein export_Homo sapiens_hsa030600.92614645
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90838558
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90774776
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90741977
57Viral carcinogenesis_Homo sapiens_hsa052030.88783178
58Chronic myeloid leukemia_Homo sapiens_hsa052200.87708504
59B cell receptor signaling pathway_Homo sapiens_hsa046620.86561090
60Apoptosis_Homo sapiens_hsa042100.85769016
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.85646756
62Colorectal cancer_Homo sapiens_hsa052100.85509848
63Leishmaniasis_Homo sapiens_hsa051400.85377598
64HTLV-I infection_Homo sapiens_hsa051660.85124131
65Systemic lupus erythematosus_Homo sapiens_hsa053220.82867652
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82811962
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82402073
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82181817
69Linoleic acid metabolism_Homo sapiens_hsa005910.81564746
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79952056
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76093507
72Folate biosynthesis_Homo sapiens_hsa007900.75230145
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.75109630
74Metabolic pathways_Homo sapiens_hsa011000.74218153
75Pentose phosphate pathway_Homo sapiens_hsa000300.73700140
76Hepatitis B_Homo sapiens_hsa051610.73468000
77Hematopoietic cell lineage_Homo sapiens_hsa046400.71277292
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70642627
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70082946
80Nitrogen metabolism_Homo sapiens_hsa009100.69842635
81Steroid biosynthesis_Homo sapiens_hsa001000.69272835
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68748628
83Glutathione metabolism_Homo sapiens_hsa004800.68250821
84MicroRNAs in cancer_Homo sapiens_hsa052060.66054954
85T cell receptor signaling pathway_Homo sapiens_hsa046600.65667320
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65543580
87Influenza A_Homo sapiens_hsa051640.64664967
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63775692
89Small cell lung cancer_Homo sapiens_hsa052220.63586725
90Notch signaling pathway_Homo sapiens_hsa043300.63211659
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.61929721
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58349498
93Circadian rhythm_Homo sapiens_hsa047100.58252739
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.58109699
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57081494
96Pyruvate metabolism_Homo sapiens_hsa006200.57049030
97Sulfur relay system_Homo sapiens_hsa041220.56836201
98Pancreatic cancer_Homo sapiens_hsa052120.56633566
99Viral myocarditis_Homo sapiens_hsa054160.56157524
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.55546739
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55406003
102Non-small cell lung cancer_Homo sapiens_hsa052230.55318988
103Thyroid cancer_Homo sapiens_hsa052160.54243300
104Oocyte meiosis_Homo sapiens_hsa041140.53341396
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.52340958
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.50490292
107Acute myeloid leukemia_Homo sapiens_hsa052210.49797482
108Collecting duct acid secretion_Homo sapiens_hsa049660.49478725
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49340419
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47510270
111Cardiac muscle contraction_Homo sapiens_hsa042600.47307717
112Ether lipid metabolism_Homo sapiens_hsa005650.47144683
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45783435
114Selenocompound metabolism_Homo sapiens_hsa004500.45450158
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.45390004
116Olfactory transduction_Homo sapiens_hsa047400.44769520
117Toxoplasmosis_Homo sapiens_hsa051450.42626511
118Retinol metabolism_Homo sapiens_hsa008300.42284333
119Asthma_Homo sapiens_hsa053100.41341873
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40804302
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40465779
122Basal cell carcinoma_Homo sapiens_hsa052170.38832816
123Allograft rejection_Homo sapiens_hsa053300.38787840
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.38613224
125Pathways in cancer_Homo sapiens_hsa052000.38033164
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.37730591
127Chemical carcinogenesis_Homo sapiens_hsa052040.37716578
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37142009
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34961553
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33985126
131Fatty acid metabolism_Homo sapiens_hsa012120.33772048
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33748303
133Endometrial cancer_Homo sapiens_hsa052130.33496268
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33370482
135Type I diabetes mellitus_Homo sapiens_hsa049400.33341880
136Taste transduction_Homo sapiens_hsa047420.32673060
137Platelet activation_Homo sapiens_hsa046110.31766970
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31016317
139Alcoholism_Homo sapiens_hsa050340.30937421
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30578279
141Regulation of autophagy_Homo sapiens_hsa041400.29074108
142Graft-versus-host disease_Homo sapiens_hsa053320.29010360
143Rheumatoid arthritis_Homo sapiens_hsa053230.28192184
144Tuberculosis_Homo sapiens_hsa051520.27892098
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27735884
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27282529
147Autoimmune thyroid disease_Homo sapiens_hsa053200.26901104
148Pertussis_Homo sapiens_hsa051330.26874281
149TNF signaling pathway_Homo sapiens_hsa046680.26466957
150Osteoclast differentiation_Homo sapiens_hsa043800.26090141
151Hippo signaling pathway_Homo sapiens_hsa043900.26044327

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