EXD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of telomere maintenance (GO:0032205)6.55068724
2negative regulation of telomerase activity (GO:0051974)5.00195798
3DNA damage induced protein phosphorylation (GO:0006975)4.58709767
4regulation of telomere maintenance via telomerase (GO:0032210)4.44954183
5snRNA processing (GO:0016180)4.30594322
6behavioral response to nicotine (GO:0035095)4.12774955
7positive regulation of protein kinase C signaling (GO:0090037)4.08171288
8positive regulation of triglyceride biosynthetic process (GO:0010867)4.05199011
9regulation of hydrogen peroxide metabolic process (GO:0010310)3.92582250
10snRNA metabolic process (GO:0016073)3.80981102
11axoneme assembly (GO:0035082)3.80293370
12phosphatidylglycerol biosynthetic process (GO:0006655)3.70317523
13L-fucose catabolic process (GO:0042355)3.67136543
14fucose catabolic process (GO:0019317)3.67136543
15L-fucose metabolic process (GO:0042354)3.67136543
16protein polyglutamylation (GO:0018095)3.48944118
17regulation of telomere maintenance (GO:0032204)3.48539303
18regulation of telomerase activity (GO:0051972)3.45118489
19lymphangiogenesis (GO:0001946)3.26761080
20cell migration in hindbrain (GO:0021535)3.25000867
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23204877
22dendritic spine morphogenesis (GO:0060997)3.22457329
23ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.19027730
24regulation of triglyceride biosynthetic process (GO:0010866)3.17320575
25interkinetic nuclear migration (GO:0022027)3.17110522
26histone H3-K4 trimethylation (GO:0080182)3.11589972
27glycerophospholipid catabolic process (GO:0046475)3.10569845
28nephron epithelium morphogenesis (GO:0072088)3.01646237
29nephron tubule morphogenesis (GO:0072078)3.01646237
30negative regulation of DNA biosynthetic process (GO:2000279)3.00425552
31auditory receptor cell stereocilium organization (GO:0060088)2.95191471
32positive regulation of triglyceride metabolic process (GO:0090208)2.93219354
33opioid receptor signaling pathway (GO:0038003)2.92294049
34epithelial cilium movement (GO:0003351)2.91052403
35cardiac right ventricle morphogenesis (GO:0003215)2.90115606
36arginine catabolic process (GO:0006527)2.86089361
37ventricular trabecula myocardium morphogenesis (GO:0003222)2.85957149
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.85340452
39cellular response to exogenous dsRNA (GO:0071360)2.81933471
40drug catabolic process (GO:0042737)2.78826781
41positive regulation of histone deacetylation (GO:0031065)2.78172528
42brain morphogenesis (GO:0048854)2.77280673
43central nervous system myelination (GO:0022010)2.75775525
44axon ensheathment in central nervous system (GO:0032291)2.75775525
45exogenous drug catabolic process (GO:0042738)2.73844976
46cerebral cortex neuron differentiation (GO:0021895)2.73723788
47endothelial cell differentiation (GO:0045446)2.72908399
48positive regulation of CREB transcription factor activity (GO:0032793)2.72644107
49negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.71607624
50meiotic chromosome segregation (GO:0045132)2.71120751
51activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.69448074
52cellular response to pH (GO:0071467)2.65449759
53indole-containing compound catabolic process (GO:0042436)2.64441331
54indolalkylamine catabolic process (GO:0046218)2.64441331
55tryptophan catabolic process (GO:0006569)2.64441331
56heart valve formation (GO:0003188)2.61630265
57cellular response to ATP (GO:0071318)2.58406148
58transmission of nerve impulse (GO:0019226)2.55691884
59positive regulation of fatty acid oxidation (GO:0046321)2.55185390
60preassembly of GPI anchor in ER membrane (GO:0016254)2.54134549
61positive regulation of DNA biosynthetic process (GO:2000573)2.50660334
62cilium movement (GO:0003341)2.48077923
63detection of light stimulus involved in sensory perception (GO:0050962)2.45989373
64detection of light stimulus involved in visual perception (GO:0050908)2.45989373
65inner ear receptor stereocilium organization (GO:0060122)2.44811640
66gamma-aminobutyric acid transport (GO:0015812)2.43542932
67C-terminal protein lipidation (GO:0006501)2.43309129
68sulfate transmembrane transport (GO:1902358)2.42383544
69positive regulation of fatty acid beta-oxidation (GO:0032000)2.41973072
70negative regulation of mast cell activation (GO:0033004)2.41885305
71negative regulation of cAMP-mediated signaling (GO:0043951)2.41360236
72regulation of synapse maturation (GO:0090128)2.40552532
73fucosylation (GO:0036065)2.40436942
74positive regulation of fatty acid transport (GO:2000193)2.38691574
75cell proliferation in forebrain (GO:0021846)2.37412255
76positive regulation of mitochondrial fission (GO:0090141)2.37230603
77peptide biosynthetic process (GO:0043043)2.36143177
78regulation of mitochondrial fission (GO:0090140)2.35842470
79mitochondrion degradation (GO:0000422)2.35664122
80retina development in camera-type eye (GO:0060041)2.35271709
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.35074413
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.35074413
83NADH dehydrogenase complex assembly (GO:0010257)2.35074413
84superoxide anion generation (GO:0042554)2.34772115
85behavioral response to ethanol (GO:0048149)2.34759195
86regulation of triglyceride metabolic process (GO:0090207)2.33336135
87basic amino acid transport (GO:0015802)2.33246615
88auditory behavior (GO:0031223)2.32782757
89fatty acid transmembrane transport (GO:1902001)2.32058496
90negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.31130510
91dermatan sulfate metabolic process (GO:0030205)2.30818082
92parturition (GO:0007567)2.30385582
93regulation of ruffle assembly (GO:1900027)2.29216930
94lytic vacuole organization (GO:0080171)2.28738009
95lysosome organization (GO:0007040)2.28738009
96base-excision repair, AP site formation (GO:0006285)2.26610788
97microtubule severing (GO:0051013)2.25394642
98regulation of synapse structural plasticity (GO:0051823)2.25342935
99positive regulation of defense response to virus by host (GO:0002230)2.24712364
100phosphatidylserine acyl-chain remodeling (GO:0036150)2.24651333

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.02213043
2EZH2_22144423_ChIP-Seq_EOC_Human3.24794788
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.20103687
4DROSHA_22980978_ChIP-Seq_HELA_Human3.02740516
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.23595849
6P68_20966046_ChIP-Seq_HELA_Human2.20693819
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15985897
8EZH2_27294783_Chip-Seq_ESCs_Mouse2.12401598
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08411516
10BCL6_27268052_Chip-Seq_Bcells_Human1.97841647
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96264523
12CTCF_27219007_Chip-Seq_Bcells_Human1.95609065
13SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94988350
14ZNF274_21170338_ChIP-Seq_K562_Hela1.94618887
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83434182
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80152884
17LXR_22292898_ChIP-Seq_THP-1_Human1.79452533
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79132358
19ERA_21632823_ChIP-Seq_H3396_Human1.74418647
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.73643921
21SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.70141050
22REST_21632747_ChIP-Seq_MESCs_Mouse1.69939876
23PHF8_20622854_ChIP-Seq_HELA_Human1.66403244
24E2F1_20622854_ChIP-Seq_HELA_Human1.65091641
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61836275
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58435881
27BCOR_27268052_Chip-Seq_Bcells_Human1.53964205
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53066232
29OCT4_19829295_ChIP-Seq_ESCs_Human1.52308296
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.50992285
31SMC4_20622854_ChIP-Seq_HELA_Human1.49386728
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48732659
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.48058003
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.40080347
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38950972
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.35259690
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.35153760
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.34188837
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33597740
40GBX2_23144817_ChIP-Seq_PC3_Human1.32467416
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32242261
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31844880
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.31678558
44SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30759888
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30044220
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29718871
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29589079
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28246952
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28196299
50MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27440333
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.27030253
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26359805
53P300_27268052_Chip-Seq_Bcells_Human1.25784848
54SA1_27219007_Chip-Seq_Bcells_Human1.25555100
55OCT4_20526341_ChIP-Seq_ESCs_Human1.25025560
56RARB_24833708_ChIP-Seq_LIVER_Mouse1.24228267
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22592332
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22038690
59CTCF_20526341_ChIP-Seq_ESCs_Human1.20856552
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19904727
61TAF2_19829295_ChIP-Seq_ESCs_Human1.19598651
62* TP63_22573176_ChIP-Seq_HFKS_Human1.19256259
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18342464
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.16817924
65P53_21459846_ChIP-Seq_SAOS-2_Human1.16259389
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.16143494
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.13196518
68TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13060015
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12323268
70VDR_22108803_ChIP-Seq_LS180_Human1.12134391
71RAC3_21632823_ChIP-Seq_H3396_Human1.10608927
72* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10377564
73P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.09890826
74MYC_19829295_ChIP-Seq_ESCs_Human1.08022120
75KDM2B_26808549_Chip-Seq_K562_Human1.07756321
76RARA_24833708_ChIP-Seq_LIVER_Mouse1.06981085
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.06481700
78CTCF_26484167_Chip-Seq_Bcells_Mouse1.06150201
79NANOG_20526341_ChIP-Seq_ESCs_Human1.06146914
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05097367
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.04325875
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.03606559
83KLF4_19829295_ChIP-Seq_ESCs_Human1.03171458
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03155116
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02964984
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.02633891
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02076727
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02076727
89CREB1_26743006_Chip-Seq_LNCaP_Human1.01309013
90RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00772501
91* FOXP1_21924763_ChIP-Seq_HESCs_Human1.00187587
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00062700
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99662574
94MYC_27129775_Chip-Seq_CORNEA_Mouse0.99431504
95WDR5_24793694_ChIP-Seq_LNCAP_Human0.98728123
96RING1B_27294783_Chip-Seq_ESCs_Mouse0.95242824
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95066873
98TP53_22573176_ChIP-Seq_HFKS_Human0.94631662
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94605841
100TP53_22127205_ChIP-Seq_IMR90_Human0.94482485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.66685926
2MP0003880_abnormal_central_pattern3.44306153
3MP0004133_heterotaxia2.81435359
4MP0002653_abnormal_ependyma_morphology2.58351654
5MP0006276_abnormal_autonomic_nervous2.39295659
6MP0005646_abnormal_pituitary_gland2.34460309
7MP0005167_abnormal_blood-brain_barrier2.24088344
8MP0004043_abnormal_pH_regulation2.20908325
9MP0001968_abnormal_touch/_nociception2.06463266
10MP0002876_abnormal_thyroid_physiology2.06440460
11MP0009384_cardiac_valve_regurgitation1.99088403
12MP0008875_abnormal_xenobiotic_pharmacok1.98800242
13MP0001986_abnormal_taste_sensitivity1.97064594
14MP0001502_abnormal_circadian_rhythm1.94001502
15MP0009745_abnormal_behavioral_response1.93597819
16MP0002822_catalepsy1.88257503
17MP0005551_abnormal_eye_electrophysiolog1.83381047
18MP0003787_abnormal_imprinting1.82383972
19MP0004145_abnormal_muscle_electrophysio1.78401670
20MP0006292_abnormal_olfactory_placode1.76421044
21MP0002249_abnormal_larynx_morphology1.75002672
22MP0003646_muscle_fatigue1.72688527
23MP0002735_abnormal_chemical_nociception1.64069647
24MP0000013_abnormal_adipose_tissue1.59733423
25MP0002572_abnormal_emotion/affect_behav1.52024966
26MP0002733_abnormal_thermal_nociception1.51913383
27MP0004270_analgesia1.51623436
28MP0001970_abnormal_pain_threshold1.51494405
29MP0003635_abnormal_synaptic_transmissio1.50382655
30MP0005645_abnormal_hypothalamus_physiol1.49779010
31MP0002837_dystrophic_cardiac_calcinosis1.48208809
32MP0002063_abnormal_learning/memory/cond1.47725375
33MP0008872_abnormal_physiological_respon1.45817592
34MP0005595_abnormal_vascular_smooth1.45694046
35MP0004147_increased_porphyrin_level1.42783479
36MP0008775_abnormal_heart_ventricle1.42274379
37MP0003172_abnormal_lysosome_physiology1.41440258
38MP0004381_abnormal_hair_follicle1.41384039
39MP0002064_seizures1.40808177
40MP0002557_abnormal_social/conspecific_i1.39226780
41MP0003879_abnormal_hair_cell1.38960352
42MP0002138_abnormal_hepatobiliary_system1.37755459
43MP0000631_abnormal_neuroendocrine_gland1.32770339
44MP0000778_abnormal_nervous_system1.32479608
45MP0002272_abnormal_nervous_system1.32261767
46MP0000015_abnormal_ear_pigmentation1.32038155
47MP0002234_abnormal_pharynx_morphology1.29907082
48MP0002127_abnormal_cardiovascular_syste1.29839802
49MP0000026_abnormal_inner_ear1.28795825
50MP0004859_abnormal_synaptic_plasticity1.25553664
51MP0003011_delayed_dark_adaptation1.25347522
52MP0003195_calcinosis1.23530561
53MP0005174_abnormal_tail_pigmentation1.21922047
54MP0000230_abnormal_systemic_arterial1.20440157
55MP0004885_abnormal_endolymph1.20346291
56MP0003137_abnormal_impulse_conducting1.19149339
57MP0002928_abnormal_bile_duct1.18983945
58MP0005670_abnormal_white_adipose1.18679607
59MP0002102_abnormal_ear_morphology1.17925760
60MP0005360_urolithiasis1.14502725
61MP0003938_abnormal_ear_development1.11745308
62MP0001501_abnormal_sleep_pattern1.10352722
63MP0000383_abnormal_hair_follicle1.10285624
64MP0005075_abnormal_melanosome_morpholog1.09118906
65MP0004130_abnormal_muscle_cell1.07721778
66MP0002933_joint_inflammation1.07149319
67MP0006072_abnormal_retinal_apoptosis1.05804152
68MP0002734_abnormal_mechanical_nocicepti1.05560170
69MP0001764_abnormal_homeostasis1.05345188
70MP0000427_abnormal_hair_cycle1.05320509
71MP0002163_abnormal_gland_morphology1.04436883
72MP0002932_abnormal_joint_morphology1.03891539
73MP0005448_abnormal_energy_balance1.02675948
74MP0004742_abnormal_vestibular_system1.00864941
75MP0000566_synostosis0.99990861
76MP0001486_abnormal_startle_reflex0.98048544
77MP0005195_abnormal_posterior_eye0.97728374
78MP0008995_early_reproductive_senescence0.95314975
79MP0002752_abnormal_somatic_nervous0.93172514
80MP0001963_abnormal_hearing_physiology0.92420582
81MP0002638_abnormal_pupillary_reflex0.90929178
82MP0005423_abnormal_somatic_nervous0.88011701
83MP0005377_hearing/vestibular/ear_phenot0.86222562
84MP0003878_abnormal_ear_physiology0.86222562
85MP0002882_abnormal_neuron_morphology0.85609701
86MP0001485_abnormal_pinna_reflex0.84535391
87MP0000003_abnormal_adipose_tissue0.83871517
88MP0009046_muscle_twitch0.82074216
89MP0008789_abnormal_olfactory_epithelium0.80416921
90MP0010329_abnormal_lipoprotein_level0.80087674
91MP0004142_abnormal_muscle_tone0.76953148
92MP0005253_abnormal_eye_physiology0.76077672
93MP0000681_abnormal_thyroid_gland0.76072156
94MP0005386_behavior/neurological_phenoty0.75756006
95MP0004924_abnormal_behavior0.75756006
96MP0002736_abnormal_nociception_after0.75249878
97MP0002184_abnormal_innervation0.75245235
98MP0001324_abnormal_eye_pigmentation0.74043086
99MP0000678_abnormal_parathyroid_gland0.73659491
100MP0005058_abnormal_lysosome_morphology0.73142576

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.33433159
2Molar tooth sign on MRI (HP:0002419)4.33433159
3Abnormality of the aortic arch (HP:0012303)3.90937731
4Chronic hepatic failure (HP:0100626)3.83307421
5Nephronophthisis (HP:0000090)3.76174311
6Pancreatic cysts (HP:0001737)3.70069137
7Cystic liver disease (HP:0006706)3.61613915
8Pancreatic fibrosis (HP:0100732)3.57089030
9Congenital stationary night blindness (HP:0007642)3.43612073
10J-shaped sella turcica (HP:0002680)3.40687264
11Delayed CNS myelination (HP:0002188)3.39618841
12True hermaphroditism (HP:0010459)3.37185846
13Bile duct proliferation (HP:0001408)3.20327856
14Abnormal biliary tract physiology (HP:0012439)3.20327856
15Abnormality of the renal medulla (HP:0100957)3.19159580
16Type II lissencephaly (HP:0007260)3.19025624
17Abnormal rod and cone electroretinograms (HP:0008323)3.14279004
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11793142
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.09020258
20Decreased circulating renin level (HP:0003351)3.04080455
21Occipital encephalocele (HP:0002085)3.03316106
22Lymphangioma (HP:0100764)2.99259222
23Hyperventilation (HP:0002883)2.95960752
24Esophageal atresia (HP:0002032)2.77021372
25Tubular atrophy (HP:0000092)2.75524346
26Polydipsia (HP:0001959)2.73922622
27Abnormal drinking behavior (HP:0030082)2.73922622
28Inability to walk (HP:0002540)2.70556661
29Adactyly (HP:0009776)2.70370275
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.60423081
31Congenital hepatic fibrosis (HP:0002612)2.56056304
32Sleep apnea (HP:0010535)2.50488076
33Clumsiness (HP:0002312)2.46709882
34Retinal dysplasia (HP:0007973)2.44949076
35Rectal prolapse (HP:0002035)2.44170232
36Prolonged QT interval (HP:0001657)2.44163112
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.42315502
38Decreased central vision (HP:0007663)2.38833469
39Obstructive sleep apnea (HP:0002870)2.37583556
40Concave nail (HP:0001598)2.32777917
41Attenuation of retinal blood vessels (HP:0007843)2.29063525
42Pendular nystagmus (HP:0012043)2.22557188
43Pigmentary retinal degeneration (HP:0001146)2.19387638
44Hypoplastic ischia (HP:0003175)2.15147991
45Tachypnea (HP:0002789)2.12834758
46Gastrointestinal atresia (HP:0002589)2.11110491
47Aplasia/Hypoplasia of the patella (HP:0006498)2.10781977
48Stridor (HP:0010307)2.10476974
49Intellectual disability, severe (HP:0010864)2.10159024
50Genetic anticipation (HP:0003743)2.10129050
51Abnormality of the renal cortex (HP:0011035)2.08579031
52Abolished electroretinogram (ERG) (HP:0000550)2.07846517
53Postaxial foot polydactyly (HP:0001830)2.05247019
54Cerebellar dysplasia (HP:0007033)2.05198090
55Absent speech (HP:0001344)2.04284449
56Hyperkalemia (HP:0002153)2.03090776
57Medial flaring of the eyebrow (HP:0010747)2.00907781
58Renal dysplasia (HP:0000110)2.00907162
59Severe muscular hypotonia (HP:0006829)1.99516239
60Polyuria (HP:0000103)1.98561180
61Dynein arm defect of respiratory motile cilia (HP:0012255)1.96648623
62Absent/shortened dynein arms (HP:0200106)1.96648623
63Increased cerebral lipofuscin (HP:0011813)1.93881538
64Optic nerve coloboma (HP:0000588)1.92312423
65Humeroradial synostosis (HP:0003041)1.91518047
66Synostosis involving the elbow (HP:0003938)1.91518047
67Anencephaly (HP:0002323)1.90891995
68Cerebral palsy (HP:0100021)1.90052610
69Vitreoretinal degeneration (HP:0000655)1.89608646
70Gait imbalance (HP:0002141)1.88906204
71Stage 5 chronic kidney disease (HP:0003774)1.88409050
72Severe Myopia (HP:0011003)1.86528717
73Aplasia/Hypoplasia of the spleen (HP:0010451)1.84614277
74Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.84217790
75Keratoconus (HP:0000563)1.83508085
76Increased corneal curvature (HP:0100692)1.83508085
77Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.83056154
78Patellar aplasia (HP:0006443)1.82125558
79Aplasia/hypoplasia of the femur (HP:0005613)1.81847420
80Broad-based gait (HP:0002136)1.81782927
81Mesangial abnormality (HP:0001966)1.79542078
82Progressive cerebellar ataxia (HP:0002073)1.78848116
83Retinitis pigmentosa (HP:0000510)1.77303091
84Abnormality of the femoral head (HP:0003368)1.76076015
85Bony spicule pigmentary retinopathy (HP:0007737)1.74811927
86Abnormality of renin-angiotensin system (HP:0000847)1.73864068
87Joint stiffness (HP:0001387)1.73266062
88Rib fusion (HP:0000902)1.70924033
89Spinal canal stenosis (HP:0003416)1.69609677
90Sclerocornea (HP:0000647)1.69136502
91Focal seizures (HP:0007359)1.68747323
92Thyroid-stimulating hormone excess (HP:0002925)1.68177890
93Lissencephaly (HP:0001339)1.67005787
94Severe visual impairment (HP:0001141)1.66477254
95Abnormal urine output (HP:0012590)1.66376989
96Retinal atrophy (HP:0001105)1.65015574
97Abnormal respiratory epithelium morphology (HP:0012253)1.64435135
98Abnormal respiratory motile cilium morphology (HP:0005938)1.64435135
99Protruding tongue (HP:0010808)1.64171231
100Progressive microcephaly (HP:0000253)1.63191789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK25.12340285
2MAP2K64.81644640
3TLK14.13342583
4SIK23.10851021
5MAP4K23.06055951
6FRK3.00471703
7WNK42.73935011
8MAPK152.52026462
9NME12.26910825
10TNK22.14907852
11ADRBK21.80293023
12SIK11.73893598
13MAPKAPK31.73077160
14MUSK1.72231225
15MAP3K71.69424386
16TIE11.67821891
17DAPK21.66806466
18BLK1.56569465
19NTRK31.48324201
20GRK11.35586808
21PINK11.28763397
22KDR1.28076056
23CASK1.27223852
24MAP3K51.24684416
25MARK11.23569163
26TAOK31.21137829
27TRIB31.19156527
28MAPK131.16777794
29INSRR1.16724262
30MARK21.15704565
31RIPK11.04861059
32HIPK21.04565514
33CAMK10.98447024
34PRKD20.95933843
35EPHA40.94271913
36NTRK20.91246335
37RPS6KA60.91129706
38CDK190.89365944
39RPS6KA20.89057008
40OXSR10.88943842
41ERBB20.88188610
42CAMKK10.86297060
43PTK2B0.85451812
44DYRK20.79416887
45MAP3K40.78345480
46PKN10.75622248
47PRKD30.73781142
48MAP3K60.73675357
49CAMK40.73033051
50BMX0.69972279
51PDPK10.67276012
52RPS6KL10.66832986
53RPS6KC10.66832986
54PRKAA10.66712422
55PIK3CA0.66548546
56ADRBK10.66368014
57CAMKK20.64008760
58STK110.63941418
59KIT0.62286558
60MAP2K40.61789125
61DYRK1B0.59841922
62PDK10.58249903
63BCKDK0.57874845
64PHKG10.57782039
65PHKG20.57782039
66IKBKB0.56656336
67TBK10.56187287
68EPHB20.55984337
69EPHA30.55119457
70PRKAA20.54315579
71PRKCI0.53738118
72PRKCZ0.52708863
73CHUK0.51679558
74MAP3K110.49101982
75PRKD10.47215132
76STK390.46348005
77EPHA20.46040704
78FGFR20.45195169
79MAP4K10.44842333
80MAPK70.44780410
81TXK0.43899675
82MAP2K20.43414681
83IKBKE0.42821381
84PTK60.41522959
85CAMK1D0.41302049
86BMPR1B0.40182011
87MAPK120.39504174
88WNK30.39124607
89CSF1R0.38700723
90FER0.38562344
91MAP2K70.38130697
92PRKCG0.37418546
93MARK30.36830754
94MAPKAPK50.36684625
95EPHB10.35492684
96EEF2K0.34756838
97PKN20.34638209
98PRKCQ0.31822629
99PRKCH0.31531768
100MAPK80.30281116

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.27446761
2Linoleic acid metabolism_Homo sapiens_hsa005912.94914486
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92401343
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.54062051
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.39361428
6Regulation of autophagy_Homo sapiens_hsa041402.26787697
7Phototransduction_Homo sapiens_hsa047442.24816321
8Sulfur relay system_Homo sapiens_hsa041222.08839196
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97090453
10Ether lipid metabolism_Homo sapiens_hsa005651.96275273
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.94067729
12Notch signaling pathway_Homo sapiens_hsa043301.86880730
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81629378
14ABC transporters_Homo sapiens_hsa020101.77803529
15Nicotine addiction_Homo sapiens_hsa050331.59461855
16Morphine addiction_Homo sapiens_hsa050321.57432767
17Butanoate metabolism_Homo sapiens_hsa006501.55191308
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53073926
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48310457
20Other glycan degradation_Homo sapiens_hsa005111.47380990
21Ovarian steroidogenesis_Homo sapiens_hsa049131.44721655
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44054332
23Arachidonic acid metabolism_Homo sapiens_hsa005901.42687302
24Caffeine metabolism_Homo sapiens_hsa002321.41094141
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.40832233
26Insulin secretion_Homo sapiens_hsa049111.38607848
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38204296
28Circadian entrainment_Homo sapiens_hsa047131.33957513
29Histidine metabolism_Homo sapiens_hsa003401.33800789
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.28616042
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.26126659
32Nitrogen metabolism_Homo sapiens_hsa009101.21306497
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21147822
34Cocaine addiction_Homo sapiens_hsa050301.18942917
35Taste transduction_Homo sapiens_hsa047421.15850643
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10573988
37Glutamatergic synapse_Homo sapiens_hsa047241.10251320
38GABAergic synapse_Homo sapiens_hsa047271.10143022
39Peroxisome_Homo sapiens_hsa041461.08833399
40Asthma_Homo sapiens_hsa053101.08819571
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08599784
42Salivary secretion_Homo sapiens_hsa049701.08108920
43GnRH signaling pathway_Homo sapiens_hsa049121.07446173
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01351093
45Axon guidance_Homo sapiens_hsa043601.01013913
46Dorso-ventral axis formation_Homo sapiens_hsa043200.97103440
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94582416
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93364061
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.92795683
50Tryptophan metabolism_Homo sapiens_hsa003800.90267234
51Glycerolipid metabolism_Homo sapiens_hsa005610.90113393
52Olfactory transduction_Homo sapiens_hsa047400.86571760
53Calcium signaling pathway_Homo sapiens_hsa040200.86130139
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84797983
55Collecting duct acid secretion_Homo sapiens_hsa049660.84052615
56Lysine degradation_Homo sapiens_hsa003100.81353659
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.79654222
58Chemical carcinogenesis_Homo sapiens_hsa052040.78689946
59Dopaminergic synapse_Homo sapiens_hsa047280.78001599
60Oxytocin signaling pathway_Homo sapiens_hsa049210.75012816
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67475070
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67025183
63Serotonergic synapse_Homo sapiens_hsa047260.66597383
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.66482227
65Cholinergic synapse_Homo sapiens_hsa047250.65199313
66Fat digestion and absorption_Homo sapiens_hsa049750.63667388
67PPAR signaling pathway_Homo sapiens_hsa033200.63030199
68Synaptic vesicle cycle_Homo sapiens_hsa047210.62381806
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60164953
70Retinol metabolism_Homo sapiens_hsa008300.59691968
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59062555
72MAPK signaling pathway_Homo sapiens_hsa040100.58081869
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57871234
74beta-Alanine metabolism_Homo sapiens_hsa004100.54498546
75Choline metabolism in cancer_Homo sapiens_hsa052310.54209267
76Lysosome_Homo sapiens_hsa041420.52929960
77AMPK signaling pathway_Homo sapiens_hsa041520.52054549
78Dilated cardiomyopathy_Homo sapiens_hsa054140.52035278
79Fanconi anemia pathway_Homo sapiens_hsa034600.49389335
80Cardiac muscle contraction_Homo sapiens_hsa042600.49380673
81Oxidative phosphorylation_Homo sapiens_hsa001900.49324890
82Bile secretion_Homo sapiens_hsa049760.48764789
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47770312
84cAMP signaling pathway_Homo sapiens_hsa040240.47250694
85Gastric acid secretion_Homo sapiens_hsa049710.46942498
86Ras signaling pathway_Homo sapiens_hsa040140.44969711
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44932251
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43176407
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.42234946
90Fatty acid degradation_Homo sapiens_hsa000710.42076384
91Fatty acid metabolism_Homo sapiens_hsa012120.41533187
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40613483
93Renin secretion_Homo sapiens_hsa049240.40066230
94Glucagon signaling pathway_Homo sapiens_hsa049220.39061262
95Long-term depression_Homo sapiens_hsa047300.38676457
96VEGF signaling pathway_Homo sapiens_hsa043700.37778742
97Circadian rhythm_Homo sapiens_hsa047100.37663491
98Selenocompound metabolism_Homo sapiens_hsa004500.34965881
99Metabolic pathways_Homo sapiens_hsa011000.34150709
100Insulin resistance_Homo sapiens_hsa049310.33569927

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