EVL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.61166919
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.46762622
3antigen processing and presentation of endogenous antigen (GO:0019883)5.34254143
4negative regulation of cell killing (GO:0031342)5.31438594
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.31438594
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.22553515
7regulation of gamma-delta T cell activation (GO:0046643)4.97283076
8regulation of gamma-delta T cell differentiation (GO:0045586)4.94159526
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.85281960
10synaptic vesicle maturation (GO:0016188)4.77801141
11leukocyte aggregation (GO:0070486)4.43041239
12proline transport (GO:0015824)4.41965011
13layer formation in cerebral cortex (GO:0021819)4.41768761
14response to interleukin-15 (GO:0070672)4.38527017
15T cell migration (GO:0072678)4.36383147
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.16978552
17cellular response to interleukin-15 (GO:0071350)4.07798418
18B cell receptor signaling pathway (GO:0050853)4.07460882
19negative regulation of lymphocyte mediated immunity (GO:0002707)4.01708237
20negative regulation of T cell mediated immunity (GO:0002710)3.97515756
21tolerance induction (GO:0002507)3.73547508
22regulation of T cell tolerance induction (GO:0002664)3.69541102
23positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.68445879
24regulation of B cell differentiation (GO:0045577)3.67495175
25negative regulation of erythrocyte differentiation (GO:0045647)3.66820302
26negative regulation of leukocyte mediated immunity (GO:0002704)3.66148175
27locomotory exploration behavior (GO:0035641)3.66095411
28positive regulation of B cell differentiation (GO:0045579)3.62866060
29positive regulation by symbiont of host defense response (GO:0052509)3.62186410
30modulation by symbiont of host defense response (GO:0052031)3.62186410
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.62186410
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.62186410
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.62186410
34modulation by symbiont of host immune response (GO:0052553)3.62186410
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60464310
36regulation of short-term neuronal synaptic plasticity (GO:0048172)3.59962060
37interferon-gamma production (GO:0032609)3.58089448
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57615213
39cell migration in hindbrain (GO:0021535)3.56263214
40signal complex assembly (GO:0007172)3.56252321
41detection of bacterium (GO:0016045)3.55588596
42vocalization behavior (GO:0071625)3.45453693
43positive regulation of granulocyte differentiation (GO:0030854)3.42907096
44detection of other organism (GO:0098543)3.42732132
45antigen receptor-mediated signaling pathway (GO:0050851)3.38072582
46regulation of alpha-beta T cell proliferation (GO:0046640)3.37669497
47neuron cell-cell adhesion (GO:0007158)3.35622145
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.33678966
49regulation of natural killer cell mediated immunity (GO:0002715)3.33678966
50pre-miRNA processing (GO:0031054)3.31666672
51T cell receptor signaling pathway (GO:0050852)3.30008325
52regulation of interleukin-2 biosynthetic process (GO:0045076)3.27259646
53regulation of tolerance induction (GO:0002643)3.25309884
54maintenance of protein location in nucleus (GO:0051457)3.25297993
55synaptic vesicle exocytosis (GO:0016079)3.24297296
56dendritic spine morphogenesis (GO:0060997)3.23204641
57regulation of NFAT protein import into nucleus (GO:0051532)3.21251938
58macrophage activation involved in immune response (GO:0002281)3.17225602
59response to muramyl dipeptide (GO:0032495)3.16696068
60protein localization to synapse (GO:0035418)3.16476916
61regulation of glutamate receptor signaling pathway (GO:1900449)3.15963264
62negative regulation of microtubule polymerization (GO:0031115)3.15862699
63positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15650621
64negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09581337
65histone H4-K5 acetylation (GO:0043981)3.09342839
66histone H4-K8 acetylation (GO:0043982)3.09342839
67response to type I interferon (GO:0034340)3.04464713
68exploration behavior (GO:0035640)3.03705616
69type I interferon signaling pathway (GO:0060337)3.02395368
70cellular response to type I interferon (GO:0071357)3.02395368
71cellular extravasation (GO:0045123)3.02024663
72mannose metabolic process (GO:0006013)3.01099979
73regulation of synaptic vesicle exocytosis (GO:2000300)2.99764948
74neuron recognition (GO:0008038)2.98150139
75positive thymic T cell selection (GO:0045059)2.97363296
76T cell homeostasis (GO:0043029)2.97069476
77positive regulation of tolerance induction (GO:0002645)2.95519564
78mucosal-associated lymphoid tissue development (GO:0048537)2.93692568
79Peyers patch development (GO:0048541)2.93692568
80antigen processing and presentation via MHC class Ib (GO:0002475)2.93483274
81positive T cell selection (GO:0043368)2.93006511
82regulation of granulocyte differentiation (GO:0030852)2.92446579
83regulation of regulatory T cell differentiation (GO:0045589)2.92328032
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91737176
85glutamate secretion (GO:0014047)2.91650642
86regulation of isotype switching to IgG isotypes (GO:0048302)2.89515520
87regulation of T cell mediated cytotoxicity (GO:0001914)2.88937939
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88501358
89immunoglobulin mediated immune response (GO:0016064)2.88420449
90negative thymic T cell selection (GO:0045060)2.88375675
91thymic T cell selection (GO:0045061)2.87693607
92clathrin coat assembly (GO:0048268)2.86908303
93negative T cell selection (GO:0043383)2.86136469
94axonal fasciculation (GO:0007413)2.85370799
95lymphocyte migration (GO:0072676)2.84509912
96negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.83614966
97histone H4-K16 acetylation (GO:0043984)2.82754748
98mast cell activation (GO:0045576)2.81987716
99regulation of synapse structural plasticity (GO:0051823)2.81951907
100central nervous system projection neuron axonogenesis (GO:0021952)2.81761384
101regulation of interleukin-4 production (GO:0032673)2.81552941
102dendrite morphogenesis (GO:0048813)2.80882980
103T cell selection (GO:0045058)2.79913790
104interferon-gamma-mediated signaling pathway (GO:0060333)2.79900178
105regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79348630
106germinal center formation (GO:0002467)2.76180437
107negative regulation of interleukin-12 production (GO:0032695)2.75569695
108histone H4-K12 acetylation (GO:0043983)2.75277539
109positive regulation of interleukin-4 production (GO:0032753)2.74929811
110positive regulation of synapse maturation (GO:0090129)2.74720582
111regulation of defense response to virus by virus (GO:0050690)2.74364117
112cerebral cortex neuron differentiation (GO:0021895)2.74227627
113pyrimidine nucleobase catabolic process (GO:0006208)2.73702482
114positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73228448
115negative regulation of innate immune response (GO:0045824)2.72941254
116regulation of MHC class I biosynthetic process (GO:0045343)2.72316394
117ionotropic glutamate receptor signaling pathway (GO:0035235)2.69948567
118regulation of dendritic cell antigen processing and presentation (GO:0002604)2.69431845
119regulation of leukocyte mediated cytotoxicity (GO:0001910)2.68746427
120regulation of alpha-beta T cell activation (GO:0046634)2.68652307
121negative regulation of adaptive immune response (GO:0002820)2.67055855
122lymphocyte homeostasis (GO:0002260)2.66978453
123positive regulation of Rap GTPase activity (GO:0032854)2.66475638
124axon extension (GO:0048675)2.65874385
125polyketide metabolic process (GO:0030638)2.65315738
126doxorubicin metabolic process (GO:0044598)2.65315738
127daunorubicin metabolic process (GO:0044597)2.65315738
128B cell homeostasis (GO:0001782)2.65256738
129histone H3-K36 demethylation (GO:0070544)2.64437447
130regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63597727
131regulation of ARF protein signal transduction (GO:0032012)2.63184280
132positive regulation of antigen processing and presentation (GO:0002579)2.63156128
133myeloid cell activation involved in immune response (GO:0002275)2.62840231
134positive regulation of interleukin-2 production (GO:0032743)2.62633357
135natural killer cell differentiation (GO:0001779)2.61815793
136histone H3-K4 trimethylation (GO:0080182)2.59786333
137nerve growth factor signaling pathway (GO:0038180)2.59698387
138NIK/NF-kappaB signaling (GO:0038061)2.59381820
139positive regulation of axon extension (GO:0045773)2.57693531
140regulation of Rap GTPase activity (GO:0032317)2.56705159
141neurotransmitter secretion (GO:0007269)2.56346215
142somite rostral/caudal axis specification (GO:0032525)2.56220955
143adaptation of signaling pathway (GO:0023058)2.53173592
144positive regulation of histone deacetylation (GO:0031065)2.51264365
145regulation of synaptic vesicle transport (GO:1902803)2.50592905
146positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.48945200
147regulation of B cell receptor signaling pathway (GO:0050855)2.48893095
148tachykinin receptor signaling pathway (GO:0007217)2.47527807
149detection of temperature stimulus (GO:0016048)2.45534257
150regulation of long-term neuronal synaptic plasticity (GO:0048169)2.43055153
151intracellular estrogen receptor signaling pathway (GO:0030520)2.40611540
152response to nerve growth factor (GO:1990089)2.40154070
153cellular response to nerve growth factor stimulus (GO:1990090)2.40154070
154stress granule assembly (GO:0034063)2.39410088
155negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.39020065
156regulation of ARF GTPase activity (GO:0032312)2.38057275
157activation of protein kinase A activity (GO:0034199)2.37486338
158synaptic vesicle docking involved in exocytosis (GO:0016081)2.35224423
159activated T cell proliferation (GO:0050798)2.35143666
160positive regulation of gamma-delta T cell activation (GO:0046645)2.34696369
161dopamine receptor signaling pathway (GO:0007212)2.32794333
162peptidyl-threonine phosphorylation (GO:0018107)2.32545838
163regulation of telomere maintenance via telomerase (GO:0032210)2.32368508
164synaptic vesicle endocytosis (GO:0048488)2.31699920
165negative regulation of telomerase activity (GO:0051974)2.31197055
166regulation of neuronal synaptic plasticity (GO:0048168)2.31070752
167neuron projection extension (GO:1990138)2.30552582
168regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.29799540
169cerebellar Purkinje cell differentiation (GO:0021702)2.29099195
170positive regulation of filopodium assembly (GO:0051491)2.27961313
171auditory behavior (GO:0031223)2.26989911
172T cell costimulation (GO:0031295)2.25631540
173hippocampus development (GO:0021766)2.25421252
174sodium ion export (GO:0071436)2.25182937
175regulation of dendritic spine morphogenesis (GO:0061001)2.24741372
176establishment of nucleus localization (GO:0040023)2.24552547
177neuromuscular process controlling balance (GO:0050885)2.23912351
178glutamate receptor signaling pathway (GO:0007215)2.22607363
179response to auditory stimulus (GO:0010996)2.21437415
180lymphocyte costimulation (GO:0031294)2.21263415
181synaptic transmission, glutamatergic (GO:0035249)2.20880777
182negative regulation of potassium ion transmembrane transport (GO:1901380)2.20783808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.27725032
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.25847536
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.38962662
4IKZF1_21737484_ChIP-ChIP_HCT116_Human2.86082712
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.85714355
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62745205
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62198336
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.52998961
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.47603582
10MYC_22102868_ChIP-Seq_BL_Human2.37780100
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.25866704
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.25866704
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.25866704
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.23464031
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.21321924
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.17429456
17MAF_26560356_Chip-Seq_TH2_Human2.14550241
18* MYB_26560356_Chip-Seq_TH2_Human2.10830522
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08132602
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05933816
21* VDR_24763502_ChIP-Seq_THP-1_Human2.05264238
22REST_21632747_ChIP-Seq_MESCs_Mouse2.04504216
23SCL_19346495_ChIP-Seq_HPC-7_Human2.04041597
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.03698659
25KDM2B_26808549_Chip-Seq_K562_Human2.01909498
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01178249
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00952226
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00952226
29* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99095341
30* KDM2B_26808549_Chip-Seq_DND41_Human1.98660458
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97329764
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.93170573
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.90371753
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88540117
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88088056
36* MYB_26560356_Chip-Seq_TH1_Human1.85914110
37TCF7_22412390_ChIP-Seq_EML_Mouse1.84985048
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.84195274
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79672735
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78540637
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78188506
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.77148251
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76624722
44* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75380297
45* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75114920
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74415002
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.72736875
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70368295
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.70357846
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68127267
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65882494
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65615678
53* GATA3_27048872_Chip-Seq_THYMUS_Human1.64343996
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62969676
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61881263
56* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61309187
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61178936
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60405114
59DROSHA_22980978_ChIP-Seq_HELA_Human1.60068975
60* KDM2B_26808549_Chip-Seq_JURKAT_Human1.60052731
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58781263
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.57597683
63* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57322579
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55944620
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55705641
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54528982
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.53630677
68* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51490149
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.51198832
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50030662
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47107473
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46851573
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42667671
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42550079
75SPI1_23547873_ChIP-Seq_NB4_Human1.39895205
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39088284
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.39063940
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37686078
79LXR_22292898_ChIP-Seq_THP-1_Human1.37470492
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34934736
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34531690
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34278018
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30998588
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.30629368
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30596314
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29757801
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.29227488
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28890327
89P68_20966046_ChIP-Seq_HELA_Human1.28306384
90* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26488404
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25954772
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.25742278
93* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25198249
94BCL6_27268052_Chip-Seq_Bcells_Human1.24552898
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23591711
96* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23214813
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23107433
98RNF2_27304074_Chip-Seq_NSC_Mouse1.22974224
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21362920
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20683906
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19755385
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18873672
103CIITA_25753668_ChIP-Seq_RAJI_Human1.18116992
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18065991
105ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15499487
106BCOR_27268052_Chip-Seq_Bcells_Human1.14030000
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12516277
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12277149
109ELF1_20517297_ChIP-Seq_JURKAT_Human1.11263889
110VDR_21846776_ChIP-Seq_THP-1_Human1.10755698
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10690656
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09138009
113* UTX_26944678_Chip-Seq_JUKART_Human1.07726232
114ELK3_25401928_ChIP-Seq_HUVEC_Human1.06943840
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06184094
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05690973
117* SPI1_23127762_ChIP-Seq_K562_Human1.04133476
118OCT4_19829295_ChIP-Seq_ESCs_Human1.04068952
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03934789
120SMC4_20622854_ChIP-Seq_HELA_Human1.03875175
121GATA1_19941826_ChIP-Seq_K562_Human1.03842773
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03702829
123PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02445699
124* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02193144
125EGR1_19374776_ChIP-ChIP_THP-1_Human1.00991901
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00612455
127* VDR_24787735_ChIP-Seq_THP-1_Human1.00029879
128CTCF_27219007_Chip-Seq_Bcells_Human1.00014632
129MAF_26560356_Chip-Seq_TH1_Human0.99209427
130* RUNX_20019798_ChIP-Seq_JUKART_Human0.97753210
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96144147
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.95639387
133RACK7_27058665_Chip-Seq_MCF-7_Human0.94882046
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93539926
135* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93268061
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92586206
137PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.92214577
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92059261
139AR_19668381_ChIP-Seq_PC3_Human0.91879827
140POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91354856
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91019183
142AR_21572438_ChIP-Seq_LNCaP_Human0.90916176
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90815262
144SA1_27219007_Chip-Seq_Bcells_Human0.90483829
145E2F1_17053090_ChIP-ChIP_MCF-7_Human0.90238671
146EED_16625203_ChIP-ChIP_MESCs_Mouse0.89762692
147VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89567040
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89460114
149CREB1_26743006_Chip-Seq_LNCaP_Human0.89191289
150CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88758389
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88667392
152CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87376042
153DPY_21335234_ChIP-Seq_ESCs_Mouse0.87318343
154CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87169914
155CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86553022
156GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85485773
157CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84418315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.26161780
2MP0003436_decreased_susceptibility_to3.47711522
3MP0004858_abnormal_nervous_system3.25029040
4MP0003122_maternal_imprinting3.13616600
5MP0003724_increased_susceptibility_to3.00712016
6MP0000685_abnormal_immune_system2.78667845
7MP0003635_abnormal_synaptic_transmissio2.69587886
8MP0005025_abnormal_response_to2.54985947
9MP0005499_abnormal_olfactory_system2.49470602
10MP0005394_taste/olfaction_phenotype2.49470602
11MP0003880_abnormal_central_pattern2.43864684
12MP0008961_abnormal_basal_metabolism2.43719618
13MP0003787_abnormal_imprinting2.40312843
14MP0004381_abnormal_hair_follicle2.32800252
15MP0002419_abnormal_innate_immunity2.28990022
16MP0002063_abnormal_learning/memory/cond2.28381116
17MP0004270_analgesia2.24484294
18MP0005423_abnormal_somatic_nervous2.23480808
19MP0000778_abnormal_nervous_system2.16025202
20MP0009333_abnormal_splenocyte_physiolog2.13436615
21MP0003121_genomic_imprinting2.08215624
22MP0003866_abnormal_defecation2.03631278
23MP0002572_abnormal_emotion/affect_behav1.96540270
24MP0003300_gastrointestinal_ulcer1.93856399
25MP0009785_altered_susceptibility_to1.92327070
26MP0002064_seizures1.91748906
27MP0000569_abnormal_digit_pigmentation1.89546972
28MP0001873_stomach_inflammation1.88614358
29MP0002184_abnormal_innervation1.84145251
30MP0009745_abnormal_behavioral_response1.83982124
31MP0010155_abnormal_intestine_physiology1.82074234
32MP0006292_abnormal_olfactory_placode1.79295134
33MP0003303_peritoneal_inflammation1.71994253
34MP0000689_abnormal_spleen_morphology1.70823498
35MP0002653_abnormal_ependyma_morphology1.70740865
36MP0002733_abnormal_thermal_nociception1.70529368
37MP0002722_abnormal_immune_system1.69020811
38MP0004947_skin_inflammation1.68385097
39MP0009046_muscle_twitch1.63816823
40MP0003890_abnormal_embryonic-extraembry1.62122883
41MP0004811_abnormal_neuron_physiology1.62117695
42MP0002148_abnormal_hypersensitivity_rea1.60243028
43MP0002734_abnormal_mechanical_nocicepti1.59871633
44MP0001486_abnormal_startle_reflex1.56862846
45MP0006082_CNS_inflammation1.56763575
46MP0002429_abnormal_blood_cell1.56265039
47MP0005464_abnormal_platelet_physiology1.56229338
48MP0002909_abnormal_adrenal_gland1.52716012
49MP0000955_abnormal_spinal_cord1.50433508
50MP0004510_myositis1.49289529
51MP0001533_abnormal_skeleton_physiology1.48010265
52MP0001968_abnormal_touch/_nociception1.45262218
53MP0001845_abnormal_inflammatory_respons1.42669340
54MP0001970_abnormal_pain_threshold1.41990922
55MP0009278_abnormal_bone_marrow1.39690383
56MP0001986_abnormal_taste_sensitivity1.39608806
57MP0002396_abnormal_hematopoietic_system1.37180804
58MP0008260_abnormal_autophagy1.36510693
59MP0002933_joint_inflammation1.35854251
60MP0001348_abnormal_lacrimal_gland1.35361725
61MP0003690_abnormal_glial_cell1.33886772
62MP0002557_abnormal_social/conspecific_i1.30044960
63MP0004130_abnormal_muscle_cell1.28021807
64MP0005257_abnormal_intraocular_pressure1.27451841
65MP0002735_abnormal_chemical_nociception1.27446308
66MP0006276_abnormal_autonomic_nervous1.26828908
67MP0002822_catalepsy1.25296341
68MP0008789_abnormal_olfactory_epithelium1.23041951
69MP0003763_abnormal_thymus_physiology1.21944574
70MP0001440_abnormal_grooming_behavior1.21126543
71MP0002882_abnormal_neuron_morphology1.18590186
72MP0005671_abnormal_response_to1.17335407
73MP0001501_abnormal_sleep_pattern1.16922714
74MP0003123_paternal_imprinting1.15399715
75MP0000604_amyloidosis1.14052298
76MP0001851_eye_inflammation1.13273605
77MP0003861_abnormal_nervous_system1.12977686
78MP0003938_abnormal_ear_development1.11684702
79MP0002067_abnormal_sensory_capabilities1.10462070
80MP0002166_altered_tumor_susceptibility1.09222080
81MP0002152_abnormal_brain_morphology1.09121865
82MP0003172_abnormal_lysosome_physiology1.08831573
83MP0002998_abnormal_bone_remodeling1.06566530
84MP0002272_abnormal_nervous_system1.05453330
85MP0008569_lethality_at_weaning1.04458909
86MP0001800_abnormal_humoral_immune1.02557181
87MP0005386_behavior/neurological_phenoty1.01601593
88MP0004924_abnormal_behavior1.01601593
89MP0003183_abnormal_peptide_metabolism0.97459963
90MP0005248_abnormal_Harderian_gland0.95912725
91MP0008469_abnormal_protein_level0.95891963
92MP0005387_immune_system_phenotype0.94988655
93MP0001790_abnormal_immune_system0.94988655
94MP0001984_abnormal_olfaction0.94713241
95MP0000465_gastrointestinal_hemorrhage0.94033831
96MP0002751_abnormal_autonomic_nervous0.92951690
97MP0001835_abnormal_antigen_presentation0.91921138
98MP0002736_abnormal_nociception_after0.90681059
99MP0001663_abnormal_digestive_system0.89748629
100MP0003705_abnormal_hypodermis_morpholog0.89299881
101MP0000703_abnormal_thymus_morphology0.88598583
102MP0003045_fibrosis0.87658062
103MP0002254_reproductive_system_inflammat0.87407873
104MP0008874_decreased_physiological_sensi0.86571076
105MP0008770_decreased_survivor_rate0.86546717
106MP0002398_abnormal_bone_marrow0.86003025
107MP0002066_abnormal_motor_capabilities/c0.84982535
108MP0003011_delayed_dark_adaptation0.84867210
109MP0002332_abnormal_exercise_endurance0.84309624
110MP0003329_amyloid_beta_deposits0.83995872
111* MP0002420_abnormal_adaptive_immunity0.82636173
112MP0002081_perinatal_lethality0.82491100
113MP0005000_abnormal_immune_tolerance0.82481373
114MP0000631_abnormal_neuroendocrine_gland0.81968069
115MP0001849_ear_inflammation0.81954742
116* MP0001819_abnormal_immune_cell0.81876552
117MP0002009_preneoplasia0.81735826
118MP0005076_abnormal_cell_differentiation0.81073660
119MP0003119_abnormal_digestive_system0.80887550
120MP0002752_abnormal_somatic_nervous0.80798330
121MP0000858_altered_metastatic_potential0.78236106
122MP0004883_abnormal_blood_vessel0.77280543
123MP0005623_abnormal_meninges_morphology0.77045963
124MP0002452_abnormal_antigen_presenting0.76595289
125MP0005058_abnormal_lysosome_morphology0.75932591
126MP0002277_abnormal_respiratory_mucosa0.75790104
127MP0003634_abnormal_glial_cell0.74853486
128MP0003191_abnormal_cellular_cholesterol0.73437972
129MP0002132_abnormal_respiratory_system0.72991936
130MP0005075_abnormal_melanosome_morpholog0.72011745
131MP0000920_abnormal_myelination0.71793199
132MP0002138_abnormal_hepatobiliary_system0.71303832
133MP0000716_abnormal_immune_system0.71175984
134MP0002723_abnormal_immune_serum0.69961679
135MP0002127_abnormal_cardiovascular_syste0.68812498
136MP0003879_abnormal_hair_cell0.66956070
137MP0005645_abnormal_hypothalamus_physiol0.66435620
138MP0002932_abnormal_joint_morphology0.65600031
139MP0000015_abnormal_ear_pigmentation0.65356609
140MP0003283_abnormal_digestive_organ0.64965719
141MP0010352_gastrointestinal_tract_polyps0.64929603
142MP0003633_abnormal_nervous_system0.64713470
143MP0005166_decreased_susceptibility_to0.64311000
144MP0003137_abnormal_impulse_conducting0.64242521
145MP0003448_altered_tumor_morphology0.63762463
146MP0001545_abnormal_hematopoietic_system0.63526167
147MP0005397_hematopoietic_system_phenotyp0.63526167
148MP0005310_abnormal_salivary_gland0.63122164
149MP0002405_respiratory_system_inflammati0.62871082
150MP0004742_abnormal_vestibular_system0.61656967
151MP0009764_decreased_sensitivity_to0.61647987
152MP0004142_abnormal_muscle_tone0.58908468
153MP0005535_abnormal_body_temperature0.58226343
154MP0004808_abnormal_hematopoietic_stem0.56678239
155MP0000490_abnormal_crypts_of0.56553621
156MP0001853_heart_inflammation0.55891712
157MP0005409_darkened_coat_color0.55011199
158MP0002693_abnormal_pancreas_physiology0.54078666
159MP0009115_abnormal_fat_cell0.53988010
160MP0002928_abnormal_bile_duct0.53597235

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.67415210
2Panhypogammaglobulinemia (HP:0003139)4.40815213
3T lymphocytopenia (HP:0005403)4.34441484
4Amyotrophic lateral sclerosis (HP:0007354)4.32598540
5Recurrent bacterial skin infections (HP:0005406)4.30888178
6Recurrent abscess formation (HP:0002722)4.21016123
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.20418844
8Recurrent fungal infections (HP:0002841)4.03822742
9Meningitis (HP:0001287)3.99074757
10Myositis (HP:0100614)3.96273704
11Abnormality of T cell number (HP:0011839)3.95057587
12Bilateral microphthalmos (HP:0007633)3.91822339
13Abnormality of the lower motor neuron (HP:0002366)3.90067381
14Abnormality of macrophages (HP:0004311)3.86581399
15Agammaglobulinemia (HP:0004432)3.55767182
16Mediastinal lymphadenopathy (HP:0100721)3.54096336
17Pustule (HP:0200039)3.52115750
18Recurrent cutaneous fungal infections (HP:0011370)3.51524540
19Chronic mucocutaneous candidiasis (HP:0002728)3.51524540
20Hepatoblastoma (HP:0002884)3.47977326
21Stomatitis (HP:0010280)3.40930482
22Optic neuritis (HP:0100653)3.38529286
23Retrobulbar optic neuritis (HP:0100654)3.38529286
24Encephalitis (HP:0002383)3.35997380
25Orchitis (HP:0100796)3.34417934
26Spontaneous hematomas (HP:0007420)3.33079033
27Vasculitis (HP:0002633)3.32674245
28Increased IgE level (HP:0003212)3.30323761
29Gastrointestinal infarctions (HP:0005244)3.22740796
30Chronic obstructive pulmonary disease (HP:0006510)3.22413160
31Obstructive lung disease (HP:0006536)3.22413160
32Recurrent viral infections (HP:0004429)3.21825355
33Abnormality of T cells (HP:0002843)3.20557705
34Recurrent gram-negative bacterial infections (HP:0005420)3.17522843
35Recurrent skin infections (HP:0001581)3.15552839
36Colitis (HP:0002583)3.14927023
37Gastrointestinal inflammation (HP:0004386)3.08568392
38Inflammation of the large intestine (HP:0002037)3.07823901
39Amblyopia (HP:0000646)3.06548401
40Recurrent bronchitis (HP:0002837)3.04635123
41Lymphopenia (HP:0001888)3.04091994
42Focal seizures (HP:0007359)2.92156338
43Severe combined immunodeficiency (HP:0004430)2.88363886
44Myokymia (HP:0002411)2.85378651
45Abnormality of the fingertips (HP:0001211)2.81496444
46Gastrointestinal stroma tumor (HP:0100723)2.80193876
47Prolonged bleeding time (HP:0003010)2.79447643
48Generalized hypotonia (HP:0001290)2.78191007
49Renal duplication (HP:0000075)2.75504505
50Cellulitis (HP:0100658)2.75405946
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.75168828
52Gingivitis (HP:0000230)2.72773524
53Pulmonary infiltrates (HP:0002113)2.65907762
54Supranuclear gaze palsy (HP:0000605)2.65650934
55Apathy (HP:0000741)2.64163118
56Papilloma (HP:0012740)2.64013148
57Verrucae (HP:0200043)2.64013148
58Visual hallucinations (HP:0002367)2.63894182
59Chest pain (HP:0100749)2.63407318
60Hemiplegia (HP:0002301)2.62662624
61Mutism (HP:0002300)2.59480018
62Febrile seizures (HP:0002373)2.58511033
63Leukocytosis (HP:0001974)2.54575783
64Hemoptysis (HP:0002105)2.51129654
65Granulocytopenia (HP:0001913)2.51033435
66Neoplasm of the heart (HP:0100544)2.47410322
67Increased IgM level (HP:0003496)2.46156727
68IgM deficiency (HP:0002850)2.45347961
69IgG deficiency (HP:0004315)2.41845137
70Diminished motivation (HP:0000745)2.41842310
71Inappropriate behavior (HP:0000719)2.41646178
72Epileptic encephalopathy (HP:0200134)2.41052779
73Hyperacusis (HP:0010780)2.39758646
74Macroorchidism (HP:0000053)2.37792364
75Hypochromic anemia (HP:0001931)2.37023516
76Slow saccadic eye movements (HP:0000514)2.36085326
77Ependymoma (HP:0002888)2.32157920
78Keratoconjunctivitis sicca (HP:0001097)2.31431331
79Abnormality of the corticospinal tract (HP:0002492)2.30596855
80Abnormality of the astrocytes (HP:0100707)2.29499874
81Astrocytoma (HP:0009592)2.29499874
82Rib fusion (HP:0000902)2.29321179
83Pulmonary embolism (HP:0002204)2.29319164
84Recurrent sinusitis (HP:0011108)2.27908287
85Atrophy/Degeneration involving motor neurons (HP:0007373)2.23530051
86Epistaxis (HP:0000421)2.21030830
87Hemiparesis (HP:0001269)2.20007652
88Abnormality of eosinophils (HP:0001879)2.19937357
89Chronic otitis media (HP:0000389)2.19238579
90Autoimmune hemolytic anemia (HP:0001890)2.19203141
91Restrictive lung disease (HP:0002091)2.18487876
92Eosinophilia (HP:0001880)2.15184910
93Abnormality of T cell physiology (HP:0011840)2.15156993
94Hypochromic microcytic anemia (HP:0004840)2.15149576
95Failure to thrive in infancy (HP:0001531)2.15103264
96Emphysema (HP:0002097)2.13686523
97Atonic seizures (HP:0010819)2.13008481
98Papilledema (HP:0001085)2.12715049
99Excessive salivation (HP:0003781)2.12194891
100Drooling (HP:0002307)2.12194891
101Focal motor seizures (HP:0011153)2.11662924
102Keratoconjunctivitis (HP:0001096)2.09646011
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06996644
104Limb dystonia (HP:0002451)2.06670001
105Hypoplasia of the thymus (HP:0000778)2.06502578
106Dialeptic seizures (HP:0011146)2.06446698
107Open mouth (HP:0000194)2.05590850
108Sepsis (HP:0100806)2.05102180
109Elevated erythrocyte sedimentation rate (HP:0003565)2.04934240
110Hypergammaglobulinemia (HP:0010702)2.02357281
111Heterotopia (HP:0002282)2.01290853
112Neuronal loss in central nervous system (HP:0002529)1.99147096
113Joint swelling (HP:0001386)1.97354288
114Absence seizures (HP:0002121)1.97124612
115Urticaria (HP:0001025)1.96675094
116Multiple enchondromatosis (HP:0005701)1.96377652
117Basal cell carcinoma (HP:0002671)1.96318476
118Progressive cerebellar ataxia (HP:0002073)1.95030690
119Abnormality of glycolipid metabolism (HP:0010969)1.93169947
120Abnormality of liposaccharide metabolism (HP:0010968)1.93169947
121Abnormality of glycosphingolipid metabolism (HP:0004343)1.93169947
122Chronic diarrhea (HP:0002028)1.91585342
123Spinal canal stenosis (HP:0003416)1.91267388
124Urinary urgency (HP:0000012)1.91145164
125Ankle clonus (HP:0011448)1.89697952
126Pointed chin (HP:0000307)1.88133863
127Horizontal nystagmus (HP:0000666)1.87610191
128Nasal polyposis (HP:0100582)1.85520016
129Viral hepatitis (HP:0006562)1.84877170
130Osteomyelitis (HP:0002754)1.83604588
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82268588
132Disinhibition (HP:0000734)1.81928663
133Sacral dimple (HP:0000960)1.81765812
134Abnormality of the nasal mucosa (HP:0000433)1.80238514
135Tented upper lip vermilion (HP:0010804)1.79796383
136Abnormality of the pleura (HP:0002103)1.79447508
137Hand muscle atrophy (HP:0009130)1.78733401
138Abnormality of oral frenula (HP:0000190)1.78680689
139Abnormality of chromosome segregation (HP:0002916)1.78549675
140Arterial thrombosis (HP:0004420)1.77699486
141Combined immunodeficiency (HP:0005387)1.76948827
142Recurrent otitis media (HP:0000403)1.76239178
143Annular pancreas (HP:0001734)1.75860721
144Neoplasm of striated muscle (HP:0009728)1.75411397
145Autoimmune thrombocytopenia (HP:0001973)1.75204612
146Insidious onset (HP:0003587)1.75123852
147Termporal pattern (HP:0011008)1.75123852
148Generalized tonic-clonic seizures (HP:0002069)1.75087834
149Ankyloglossia (HP:0010296)1.74594341
150Abnormality of binocular vision (HP:0011514)1.73895193
151Diplopia (HP:0000651)1.73895193
152Ocular albinism (HP:0001107)1.73641015
153Hyperventilation (HP:0002883)1.72173154
154Gingival bleeding (HP:0000225)1.71891506
155Insomnia (HP:0100785)1.71865510
156Microcytic anemia (HP:0001935)1.71381770
157Obstructive sleep apnea (HP:0002870)1.70909595
158Large earlobe (HP:0009748)1.70009214
159Urinary bladder sphincter dysfunction (HP:0002839)1.69134543
160Uterine leiomyosarcoma (HP:0002891)1.68870914
161Leiomyosarcoma (HP:0100243)1.68870914
162Depression (HP:0000716)1.68433457
163Malignant neoplasm of the central nervous system (HP:0100836)1.66466602
164Genetic anticipation (HP:0003743)1.66141571
165Abnormality of the motor neurons (HP:0002450)1.64761537
166Abnormal neuron morphology (HP:0012757)1.64761537
167Transitional cell carcinoma of the bladder (HP:0006740)1.63288141
168Dislocated radial head (HP:0003083)1.60597116
169Absent frontal sinuses (HP:0002688)1.59894591
170Resting tremor (HP:0002322)1.59078854
171Bifid tongue (HP:0010297)1.58445919
172Intestinal fistula (HP:0100819)1.57494104
173Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.56747478
174Bladder carcinoma (HP:0002862)1.56306800
175Bladder neoplasm (HP:0009725)1.56306800
176Abnormality of the radial head (HP:0003995)1.55847693
177Rapidly progressive (HP:0003678)1.54031414
178Increased nuchal translucency (HP:0010880)1.53947376
179Inability to walk (HP:0002540)1.53209137
180Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.52977927
181Progressive inability to walk (HP:0002505)1.52879014
182Abnormality of the intervertebral disk (HP:0005108)1.52475967
183Elfin facies (HP:0004428)1.52459135
184Exotropia (HP:0000577)1.52050563
185Abnormality of the musculature of the hand (HP:0001421)1.51919106
186Stereotypic behavior (HP:0000733)1.51877065
187Aplasia/Hypoplasia of the sternum (HP:0006714)1.51734740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.26626239
2MARK14.07244366
3MAP3K93.23428035
4GRK53.16734265
5GRK63.05016982
6TYRO33.03119265
7SIK22.94058703
8MAP3K102.37161796
9TNK22.29982639
10NTRK22.24838409
11TYK22.21183302
12BTK1.86997491
13NTRK31.86697196
14MAP4K11.81182230
15NTRK11.64984014
16CSF1R1.61760962
17MARK21.60822061
18MAP3K41.55778216
19IKBKE1.54882666
20PAK61.54759133
21ERN11.50659915
22MINK11.49928435
23TGFBR21.43794081
24JAK31.42289719
25FGFR31.40278109
26ALK1.37783506
27TAOK11.31562170
28GRK71.30947606
29LATS21.29314678
30TAOK31.29267395
31IRAK41.28404574
32MAP2K41.27496716
33ADRBK21.23171861
34STK101.22419983
35SIK11.17588422
36EPHA41.17233124
37PRKCH1.16142053
38RIPK41.15144676
39MAP3K111.14631554
40MAP3K141.13038583
41DAPK21.12691683
42MAPK71.11831263
43KSR21.08929368
44MAPK131.08545497
45UHMK11.08489446
46LYN1.05624094
47CAMK41.05247417
48EPHB11.05115686
49KSR11.04114258
50CAMKK21.03904049
51TRIB31.03427815
52DYRK21.02332522
53MATK1.00727170
54ITK0.98661596
55RIPK10.98244285
56WNK10.95628843
57TBK10.95081041
58JAK20.93831811
59CDK50.93314526
60EEF2K0.93065289
61PKN20.92862888
62FES0.90939535
63MAP2K30.89088308
64GRK10.88525317
65HIPK20.87152599
66TEC0.86581517
67PRKCQ0.85437161
68PASK0.84872796
69MAPK120.83767352
70ICK0.81405891
71KIT0.81070859
72STK110.80822330
73PHKG20.80307333
74PHKG10.80307333
75HCK0.80230715
76MOS0.80093701
77CSK0.76615495
78NLK0.75741378
79CAMKK10.74255401
80SYK0.73830275
81SMG10.73259514
82DYRK1A0.72909126
83FGR0.72870283
84MAP3K70.72011607
85FGFR20.69513819
86PDPK10.68648167
87RET0.68562269
88CDK150.68210319
89TXK0.68105366
90PRKD30.67796832
91MAP3K10.67332153
92PDGFRA0.66965785
93CDK180.66522912
94IKBKB0.66137112
95SGK30.63869218
96PTK60.63306295
97SGK20.63240703
98FYN0.63003745
99CAMK1G0.61573747
100STK380.61565508
101CDK11A0.61304739
102MAP2K70.61050843
103DYRK1B0.60732231
104CDK140.60657626
105MAP3K130.60259103
106DAPK10.58106347
107PRKD20.56957523
108SGK4940.55599002
109SGK2230.55599002
110RPS6KL10.54919313
111RPS6KC10.54919313
112CSNK1G20.53150310
113MAP2K20.52137251
114PAK30.50646206
115JAK10.50490833
116MAPK110.49757744
117ADRBK10.49600764
118LRRK20.48745307
119PNCK0.48318296
120RPS6KA60.48070123
121LCK0.47087841
122PRKCG0.46904219
123CDK40.45341586
124MAP3K120.45223130
125PIM10.43771591
126MAPK40.42649576
127MAPK100.42233736
128PDK10.42076936
129NEK60.41479109
130ZAP700.41387877
131CAMK10.41292304
132FGFR40.40714737
133PRPF4B0.39177530
134RPS6KA20.38161363
135PRKCZ0.37513360
136BLK0.36407855
137PDGFRB0.36212711
138INSR0.36061615
139MAPK80.34357682
140MARK30.34054619
141MAP2K60.33709913
142SIK30.32735479
143CDC42BPA0.31852932

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.38050253
2Allograft rejection_Homo sapiens_hsa053302.30416718
3Autoimmune thyroid disease_Homo sapiens_hsa053202.25064589
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70496697
5Olfactory transduction_Homo sapiens_hsa047401.70081848
6Nicotine addiction_Homo sapiens_hsa050331.68918251
7Synaptic vesicle cycle_Homo sapiens_hsa047211.68643840
8Type I diabetes mellitus_Homo sapiens_hsa049401.67042508
9Staphylococcus aureus infection_Homo sapiens_hsa051501.64210466
10Long-term potentiation_Homo sapiens_hsa047201.63893255
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.63168050
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60933807
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60540003
14T cell receptor signaling pathway_Homo sapiens_hsa046601.56640571
15Glutamatergic synapse_Homo sapiens_hsa047241.53913892
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51813044
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50939370
18GABAergic synapse_Homo sapiens_hsa047271.48228517
19Hematopoietic cell lineage_Homo sapiens_hsa046401.48215188
20Antigen processing and presentation_Homo sapiens_hsa046121.46482885
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44868945
22B cell receptor signaling pathway_Homo sapiens_hsa046621.42872312
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.42588764
24Dopaminergic synapse_Homo sapiens_hsa047281.42277956
25Morphine addiction_Homo sapiens_hsa050321.41731505
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41531176
27Primary immunodeficiency_Homo sapiens_hsa053401.40408404
28Colorectal cancer_Homo sapiens_hsa052101.36145186
29Circadian entrainment_Homo sapiens_hsa047131.33102190
30Axon guidance_Homo sapiens_hsa043601.32947638
31mTOR signaling pathway_Homo sapiens_hsa041501.32105510
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30438173
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29977339
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29976793
35Neurotrophin signaling pathway_Homo sapiens_hsa047221.28113094
36Cholinergic synapse_Homo sapiens_hsa047251.25743033
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25070010
38GnRH signaling pathway_Homo sapiens_hsa049121.22472973
39VEGF signaling pathway_Homo sapiens_hsa043701.20186701
40Oxytocin signaling pathway_Homo sapiens_hsa049211.17917176
41Asthma_Homo sapiens_hsa053101.17688175
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.17349142
43Amphetamine addiction_Homo sapiens_hsa050311.15183450
44Long-term depression_Homo sapiens_hsa047301.13640560
45Glioma_Homo sapiens_hsa052141.13633568
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13078828
47Renin secretion_Homo sapiens_hsa049241.11966357
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11618853
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11371118
50Non-small cell lung cancer_Homo sapiens_hsa052231.10146340
51Cocaine addiction_Homo sapiens_hsa050301.09674231
52Salivary secretion_Homo sapiens_hsa049701.09216258
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09123013
54Endometrial cancer_Homo sapiens_hsa052131.08691154
55Influenza A_Homo sapiens_hsa051641.08249601
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08249540
57Dorso-ventral axis formation_Homo sapiens_hsa043201.05976794
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.05834298
59Gap junction_Homo sapiens_hsa045401.05787536
60Estrogen signaling pathway_Homo sapiens_hsa049151.05485643
61Serotonergic synapse_Homo sapiens_hsa047261.05445902
62ErbB signaling pathway_Homo sapiens_hsa040121.04271229
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02720603
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01653783
65Chemokine signaling pathway_Homo sapiens_hsa040621.01542824
66Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01529067
67Viral myocarditis_Homo sapiens_hsa054161.00515473
68Osteoclast differentiation_Homo sapiens_hsa043801.00057951
69Gastric acid secretion_Homo sapiens_hsa049710.99831494
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99397852
71Choline metabolism in cancer_Homo sapiens_hsa052310.98996600
72Taste transduction_Homo sapiens_hsa047420.98582599
73Herpes simplex infection_Homo sapiens_hsa051680.98345705
74Pancreatic cancer_Homo sapiens_hsa052120.97654772
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97160878
76Renal cell carcinoma_Homo sapiens_hsa052110.94831006
77Other glycan degradation_Homo sapiens_hsa005110.94614668
78TNF signaling pathway_Homo sapiens_hsa046680.93208920
79MAPK signaling pathway_Homo sapiens_hsa040100.92697084
80Rap1 signaling pathway_Homo sapiens_hsa040150.91250196
81Chronic myeloid leukemia_Homo sapiens_hsa052200.90757719
82Type II diabetes mellitus_Homo sapiens_hsa049300.89097306
83cAMP signaling pathway_Homo sapiens_hsa040240.86745595
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83947501
85Hepatitis C_Homo sapiens_hsa051600.83764542
86Insulin secretion_Homo sapiens_hsa049110.83247860
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.82819180
88Endocytosis_Homo sapiens_hsa041440.80021493
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79862579
90Acute myeloid leukemia_Homo sapiens_hsa052210.79213871
91Malaria_Homo sapiens_hsa051440.79177242
92Calcium signaling pathway_Homo sapiens_hsa040200.78560776
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76864726
94Prolactin signaling pathway_Homo sapiens_hsa049170.76014425
95Melanogenesis_Homo sapiens_hsa049160.75579631
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73906783
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73215775
98Ras signaling pathway_Homo sapiens_hsa040140.72583711
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70947384
100Notch signaling pathway_Homo sapiens_hsa043300.69928376
101Leishmaniasis_Homo sapiens_hsa051400.69605739
102Wnt signaling pathway_Homo sapiens_hsa043100.69269973
103Tuberculosis_Homo sapiens_hsa051520.68431144
104Inositol phosphate metabolism_Homo sapiens_hsa005620.68172742
105Rheumatoid arthritis_Homo sapiens_hsa053230.67574764
106Apoptosis_Homo sapiens_hsa042100.66881806
107Phagosome_Homo sapiens_hsa041450.66620520
108Platelet activation_Homo sapiens_hsa046110.65609686
109HTLV-I infection_Homo sapiens_hsa051660.65590138
110mRNA surveillance pathway_Homo sapiens_hsa030150.64758350
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64687707
112Dilated cardiomyopathy_Homo sapiens_hsa054140.63937777
113FoxO signaling pathway_Homo sapiens_hsa040680.63920289
114Epstein-Barr virus infection_Homo sapiens_hsa051690.61702081
115Oocyte meiosis_Homo sapiens_hsa041140.61315016
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.60162437
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.59526769
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59202610
119Toxoplasmosis_Homo sapiens_hsa051450.58789737
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.58314717
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58050558
122Salmonella infection_Homo sapiens_hsa051320.57830723
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55388387
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54853195
125Pathways in cancer_Homo sapiens_hsa052000.54445021
126Thyroid cancer_Homo sapiens_hsa052160.54426161
127Proteoglycans in cancer_Homo sapiens_hsa052050.54348180
128Hepatitis B_Homo sapiens_hsa051610.53104771
129Measles_Homo sapiens_hsa051620.52029075
130Viral carcinogenesis_Homo sapiens_hsa052030.50409782
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48062684
132Insulin resistance_Homo sapiens_hsa049310.47240070
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46100944
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.45839274

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