EVI2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.89045107
2regulation of B cell receptor signaling pathway (GO:0050855)4.89672075
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.81021364
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.81021364
5detection of bacterium (GO:0016045)4.73747307
6leukocyte aggregation (GO:0070486)4.72289818
7detection of molecule of bacterial origin (GO:0032490)4.71343654
8antigen processing and presentation of endogenous antigen (GO:0019883)4.62238348
9detection of external biotic stimulus (GO:0098581)4.51549878
10immunoglobulin mediated immune response (GO:0016064)4.41675233
11positive regulation of gamma-delta T cell activation (GO:0046645)4.40217169
12neutrophil activation involved in immune response (GO:0002283)4.39597472
13positive regulation of B cell differentiation (GO:0045579)4.32936678
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.27521869
15response to interleukin-15 (GO:0070672)4.26933635
16negative regulation of lymphocyte mediated immunity (GO:0002707)4.26693912
17microglial cell activation (GO:0001774)4.19151356
18respiratory burst (GO:0045730)4.12366711
19regulation of B cell differentiation (GO:0045577)4.04929736
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.03824218
21positive regulation by organism of defense response of other organism involved in symbiotic interact4.03824218
22modulation by symbiont of host immune response (GO:0052553)4.03824218
23positive regulation by symbiont of host defense response (GO:0052509)4.03824218
24modulation by symbiont of host defense response (GO:0052031)4.03824218
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.03824218
26response to peptidoglycan (GO:0032494)4.02777062
27cellular response to interleukin-15 (GO:0071350)4.02254139
28negative regulation of phagocytosis (GO:0050765)3.99386787
29detection of biotic stimulus (GO:0009595)3.98818273
30regulation of interferon-beta biosynthetic process (GO:0045357)3.95117196
31Arp2/3 complex-mediated actin nucleation (GO:0034314)3.94922080
32negative regulation of T cell mediated immunity (GO:0002710)3.85310856
33defense response to protozoan (GO:0042832)3.84039404
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.76696085
35negative regulation of leukocyte mediated immunity (GO:0002704)3.74627866
36mast cell activation (GO:0045576)3.73943523
37antigen processing and presentation via MHC class Ib (GO:0002475)3.71822366
38macrophage activation (GO:0042116)3.71777522
39response to protozoan (GO:0001562)3.67076177
40ribosomal small subunit assembly (GO:0000028)3.66527648
41leukocyte migration involved in inflammatory response (GO:0002523)3.63780398
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.60412717
43B cell receptor signaling pathway (GO:0050853)3.56767918
44cellular extravasation (GO:0045123)3.52570697
45negative T cell selection (GO:0043383)3.52449628
46negative thymic T cell selection (GO:0045060)3.49427399
47neutrophil mediated immunity (GO:0002446)3.48576144
48neutrophil activation (GO:0042119)3.47740191
49B cell mediated immunity (GO:0019724)3.44129769
50positive thymic T cell selection (GO:0045059)3.43225865
51regulation of mast cell activation (GO:0033003)3.42280469
52positive regulation of interferon-alpha production (GO:0032727)3.41055284
53regulation of tolerance induction (GO:0002643)3.38506460
54regulation of T cell tolerance induction (GO:0002664)3.38115709
55production of molecular mediator involved in inflammatory response (GO:0002532)3.35514134
56granulocyte activation (GO:0036230)3.30213506
57positive regulation of mast cell activation (GO:0033005)3.27554714
58myeloid cell activation involved in immune response (GO:0002275)3.23915850
59regulation of interferon-alpha production (GO:0032647)3.22375581
60activated T cell proliferation (GO:0050798)3.18748551
61regulation of mast cell degranulation (GO:0043304)3.18440067
62regulation of alpha-beta T cell proliferation (GO:0046640)3.14047089
63response to interferon-beta (GO:0035456)3.13899528
64regulation of leukocyte degranulation (GO:0043300)3.13656374
65dendritic cell migration (GO:0036336)3.13195971
66cellular response to type I interferon (GO:0071357)3.12722382
67type I interferon signaling pathway (GO:0060337)3.12722382
68positive T cell selection (GO:0043368)3.11959933
69response to type I interferon (GO:0034340)3.11836569
70regulation of T cell mediated cytotoxicity (GO:0001914)3.10459446
71tolerance induction (GO:0002507)3.10064946
72negative regulation of cell killing (GO:0031342)3.10014571
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10014571
74dendritic cell chemotaxis (GO:0002407)3.09453862
75megakaryocyte development (GO:0035855)3.07882749
76T cell migration (GO:0072678)3.07641548
77negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06442548
78negative regulation of T-helper cell differentiation (GO:0045623)3.06442548
79response to host immune response (GO:0052572)3.06175161
80response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06175161
81germinal center formation (GO:0002467)3.05563956
82T cell selection (GO:0045058)3.05549074
83leukocyte degranulation (GO:0043299)3.04827908
84regulation of regulatory T cell differentiation (GO:0045589)3.04636166
85definitive hemopoiesis (GO:0060216)3.02029207
86actin nucleation (GO:0045010)3.01814126
87myeloid dendritic cell activation (GO:0001773)3.01190842
88positive regulation of T cell mediated cytotoxicity (GO:0001916)3.00701859
89negative regulation of erythrocyte differentiation (GO:0045647)3.00304626
90interferon-gamma-mediated signaling pathway (GO:0060333)2.98724564
91regulation of gamma-delta T cell differentiation (GO:0045586)2.97817647
92lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97174558
93negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.96946726
94regulation of T-helper 2 cell differentiation (GO:0045628)2.96321618
95regulation of natural killer cell mediated immunity (GO:0002715)2.95974921
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.95974921
97macrophage activation involved in immune response (GO:0002281)2.94932135
98response to fungus (GO:0009620)2.94800266
99regulation of mast cell activation involved in immune response (GO:0033006)2.94559634
100pinocytosis (GO:0006907)2.94460624
101regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94281407
102regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93327659
103positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.93055831
104mast cell activation involved in immune response (GO:0002279)2.92912639
105mast cell degranulation (GO:0043303)2.92912639
106regulation of gamma-delta T cell activation (GO:0046643)2.90082785
107interferon-gamma production (GO:0032609)2.87975887
108positive regulation of mast cell degranulation (GO:0043306)2.82685398
109positive regulation of mast cell activation involved in immune response (GO:0033008)2.82685398
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.82010403
111response to host (GO:0075136)2.82010403
112response to host defenses (GO:0052200)2.82010403
113regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78005459
114cellular response to interferon-beta (GO:0035458)2.77317903
115cellular response to zinc ion (GO:0071294)2.76875067
116positive regulation of antigen processing and presentation (GO:0002579)2.74690617
117regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74183671
118leukocyte cell-cell adhesion (GO:0007159)2.73347642
119regulation of interleukin-12 biosynthetic process (GO:0045075)2.72945110
120myeloid leukocyte mediated immunity (GO:0002444)2.71916466
121leukocyte mediated cytotoxicity (GO:0001909)2.71084062
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.70704104
123positive regulation of interferon-beta production (GO:0032728)2.69619676
124myeloid dendritic cell differentiation (GO:0043011)2.67763606
125myeloid leukocyte activation (GO:0002274)2.67723320
126detection of other organism (GO:0098543)2.67626824
127T cell homeostasis (GO:0043029)2.65875749
128defense response to fungus (GO:0050832)2.63267704
129negative regulation of interleukin-12 production (GO:0032695)2.63048952
130response to muramyl dipeptide (GO:0032495)2.62907403
131mature B cell differentiation (GO:0002335)2.62612635
132response to interferon-alpha (GO:0035455)2.62502977
133necroptotic process (GO:0070266)2.62394759
134positive regulation of macrophage differentiation (GO:0045651)2.62118554
135regulation of growth of symbiont in host (GO:0044126)2.61494678
136negative regulation of growth of symbiont in host (GO:0044130)2.61494678
137negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.61494678
138modulation of growth of symbiont involved in interaction with host (GO:0044144)2.61494678
139negative regulation of mast cell activation (GO:0033004)2.57530216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.75515091
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.53207937
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.52439691
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.88982575
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.81992846
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73301136
7SCL_19346495_ChIP-Seq_HPC-7_Human3.38963193
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23263246
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.21999889
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.18097328
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11315055
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.94120203
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89319241
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.86301006
15* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.84298930
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.71523469
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69882700
18SPI1_23547873_ChIP-Seq_NB4_Human2.67756907
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.55319024
20VDR_21846776_ChIP-Seq_THP-1_Human2.46489228
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41614639
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.38699530
23MYB_26560356_Chip-Seq_TH2_Human2.29464294
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29273217
25MYC_22102868_ChIP-Seq_BL_Human2.24798086
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21988292
27* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.14702433
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13473696
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.08771523
30VDR_24763502_ChIP-Seq_THP-1_Human2.06987871
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01962701
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00840714
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00181846
34MAF_26560356_Chip-Seq_TH1_Human1.99671102
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96880313
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96344404
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.93262965
38RUNX_20019798_ChIP-Seq_JUKART_Human1.93032372
39* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92836586
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.92303582
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.91774031
42* MYB_26560356_Chip-Seq_TH1_Human1.90515136
43VDR_24787735_ChIP-Seq_THP-1_Human1.84366973
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82689695
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.79287286
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.77523511
47* UTX_26944678_Chip-Seq_JUKART_Human1.70414805
48SPI1_23127762_ChIP-Seq_K562_Human1.70023035
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69881200
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65238728
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61294173
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60167951
53GATA1_22025678_ChIP-Seq_K562_Human1.55994249
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.54296559
55GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.50461630
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48635494
57KDM2B_26808549_Chip-Seq_DND41_Human1.46116723
58TCF7_22412390_ChIP-Seq_EML_Mouse1.45645802
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44685827
60* PU_27001747_Chip-Seq_BMDM_Mouse1.44376926
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43284798
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.33997214
63CIITA_25753668_ChIP-Seq_RAJI_Human1.32656031
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32571887
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32347186
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31430442
67* GATA3_27048872_Chip-Seq_THYMUS_Human1.30635945
68VDR_23849224_ChIP-Seq_CD4+_Human1.30332940
69* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24670073
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23190139
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22701673
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21207172
73* MAF_26560356_Chip-Seq_TH2_Human1.20083970
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18388504
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16791544
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16247923
77FOXP3_21729870_ChIP-Seq_TREG_Human1.14512946
78GATA3_26560356_Chip-Seq_TH2_Human1.13811611
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.12732499
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.11575025
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11461097
82* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08223101
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.07746623
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.07432529
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07377546
86MYC_18555785_ChIP-Seq_MESCs_Mouse1.07186126
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06668399
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06354127
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06345334
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05687949
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05589132
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05044279
93* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04176281
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03867614
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02747738
96ELK1_19687146_ChIP-ChIP_HELA_Human1.01387723
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.00609387
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.00391674
99* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99968274
100GATA1_19941826_ChIP-Seq_K562_Human0.99215639
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98210420
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.98081555
103* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94126185
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93349109
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90700527
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90586428
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90367871
108MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90196974
109TFEB_21752829_ChIP-Seq_HELA_Human0.89513094
110BCL6_27268052_Chip-Seq_Bcells_Human0.88123178
111ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87792960
112RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87675433
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87293211
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87190304
115GATA2_19941826_ChIP-Seq_K562_Human0.86197171
116SRF_21415370_ChIP-Seq_HL-1_Mouse0.85222074
117* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84028083
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82410067
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82156516
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.78049171
121NCOR1_26117541_ChIP-Seq_K562_Human0.77701105
122BCOR_27268052_Chip-Seq_Bcells_Human0.77537498
123JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.77006663
124SMRT_27268052_Chip-Seq_Bcells_Human0.76754281
125LXR_22292898_ChIP-Seq_THP-1_Human0.76460037
126SPI1_20517297_ChIP-Seq_HL60_Human0.75330669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.56172867
2MP0009785_altered_susceptibility_to3.53532827
3MP0003436_decreased_susceptibility_to3.40259244
4MP0005671_abnormal_response_to3.15546337
5MP0002396_abnormal_hematopoietic_system3.00540623
6MP0002419_abnormal_innate_immunity2.92392952
7MP0000685_abnormal_immune_system2.92247598
8MP0005000_abnormal_immune_tolerance2.90613880
9MP0005025_abnormal_response_to2.90509312
10MP0001800_abnormal_humoral_immune2.85698223
11MP0002148_abnormal_hypersensitivity_rea2.73164742
12MP0002452_abnormal_antigen_presenting2.71800094
13MP0005387_immune_system_phenotype2.67452027
14MP0001790_abnormal_immune_system2.67452027
15MP0002723_abnormal_immune_serum2.59544097
16MP0002420_abnormal_adaptive_immunity2.58877733
17MP0005464_abnormal_platelet_physiology2.58704305
18MP0001819_abnormal_immune_cell2.57386906
19MP0003303_peritoneal_inflammation2.48787898
20MP0003724_increased_susceptibility_to2.45960943
21MP0002398_abnormal_bone_marrow2.32308782
22MP0001853_heart_inflammation2.29880294
23MP0005397_hematopoietic_system_phenotyp2.24752823
24MP0001545_abnormal_hematopoietic_system2.24752823
25MP0004808_abnormal_hematopoietic_stem2.14417549
26MP0000716_abnormal_immune_system2.12671470
27MP0003763_abnormal_thymus_physiology2.12471458
28MP0002166_altered_tumor_susceptibility2.10332590
29MP0002405_respiratory_system_inflammati2.09732005
30MP0006082_CNS_inflammation2.04591162
31MP0005174_abnormal_tail_pigmentation2.03635283
32MP0000689_abnormal_spleen_morphology1.97344849
33MP0009278_abnormal_bone_marrow1.92913505
34MP0009333_abnormal_splenocyte_physiolog1.87331232
35MP0002006_tumorigenesis1.84812944
36MP0002722_abnormal_immune_system1.84538731
37MP0002429_abnormal_blood_cell1.83806031
38MP0008260_abnormal_autophagy1.83092772
39MP0010155_abnormal_intestine_physiology1.81277365
40MP0001845_abnormal_inflammatory_respons1.80813748
41MP0003172_abnormal_lysosome_physiology1.76949451
42MP0005058_abnormal_lysosome_morphology1.76467370
43MP0000465_gastrointestinal_hemorrhage1.75163641
44MP0001533_abnormal_skeleton_physiology1.59699708
45MP0001873_stomach_inflammation1.57649241
46MP0002277_abnormal_respiratory_mucosa1.53593480
47MP0005451_abnormal_body_composition1.49586012
48MP0000490_abnormal_crypts_of1.49532007
49MP0004381_abnormal_hair_follicle1.47874206
50MP0008469_abnormal_protein_level1.47715512
51MP0000343_altered_response_to1.45878725
52MP0004947_skin_inflammation1.45582482
53MP0000858_altered_metastatic_potential1.41850162
54MP0009764_decreased_sensitivity_to1.40494483
55MP0003866_abnormal_defecation1.38116121
56MP0000703_abnormal_thymus_morphology1.37288941
57MP0003300_gastrointestinal_ulcer1.36098093
58MP0003183_abnormal_peptide_metabolism1.33404966
59MP0008057_abnormal_DNA_replication1.30578315
60MP0005075_abnormal_melanosome_morpholog1.28462861
61MP0004510_myositis1.23671923
62MP0003191_abnormal_cellular_cholesterol1.22988450
63MP0000015_abnormal_ear_pigmentation1.20832190
64MP0003448_altered_tumor_morphology1.20157221
65MP0005310_abnormal_salivary_gland1.15760572
66MP0002095_abnormal_skin_pigmentation1.15494369
67MP0003693_abnormal_embryo_hatching1.14736569
68MP0003656_abnormal_erythrocyte_physiolo1.11440699
69MP0002933_joint_inflammation1.06057575
70MP0003690_abnormal_glial_cell1.04243808
71MP0002019_abnormal_tumor_incidence1.03605585
72MP0003075_altered_response_to1.02752230
73MP0002132_abnormal_respiratory_system1.00158873
74MP0010094_abnormal_chromosome_stability0.99058024
75MP0000569_abnormal_digit_pigmentation0.97457685
76MP0001851_eye_inflammation0.97037869
77MP0006054_spinal_hemorrhage0.92980618
78MP0003828_pulmonary_edema0.92177857
79MP0003045_fibrosis0.91411777
80MP0008007_abnormal_cellular_replicative0.90892592
81MP0010307_abnormal_tumor_latency0.90158833
82MP0003077_abnormal_cell_cycle0.86318645
83MP0009763_increased_sensitivity_to0.85219585
84MP0001986_abnormal_taste_sensitivity0.84744935
85MP0002009_preneoplasia0.82655679
86MP0008004_abnormal_stomach_pH0.82238558
87MP0000604_amyloidosis0.79651302
88MP0005166_decreased_susceptibility_to0.78009652
89MP0003111_abnormal_nucleus_morphology0.73716139
90MP0000371_diluted_coat_color0.72021118
91MP0008058_abnormal_DNA_repair0.71922232
92MP0001663_abnormal_digestive_system0.70155276
93MP0002998_abnormal_bone_remodeling0.69331845
94MP0000313_abnormal_cell_death0.69079117
95MP0002138_abnormal_hepatobiliary_system0.67768831
96MP0004147_increased_porphyrin_level0.66590850
97MP0003186_abnormal_redox_activity0.66569508
98MP0003943_abnormal_hepatobiliary_system0.65894363
99MP0005390_skeleton_phenotype0.64943403
100MP0003806_abnormal_nucleotide_metabolis0.64913895
101MP0000249_abnormal_blood_vessel0.62798305
102MP0004130_abnormal_muscle_cell0.62374490
103MP0008874_decreased_physiological_sensi0.61357013
104MP0009840_abnormal_foam_cell0.60214190
105MP0010352_gastrointestinal_tract_polyps0.58954967
106MP0003221_abnormal_cardiomyocyte_apopto0.58525076
107MP0005409_darkened_coat_color0.56645874
108MP0008873_increased_physiological_sensi0.55589276
109MP0003252_abnormal_bile_duct0.53170795
110MP0005164_abnormal_response_to0.51645316
111MP0009765_abnormal_xenobiotic_induced0.51311597
112MP0002928_abnormal_bile_duct0.50714191
113MP0004883_abnormal_blood_vessel0.50476044
114MP0005388_respiratory_system_phenotype0.49973705
115MP0002133_abnormal_respiratory_system0.49973705
116MP0003795_abnormal_bone_structure0.49925909
117MP0005023_abnormal_wound_healing0.49820543
118MP0004484_altered_response_of0.49295372
119MP0005319_abnormal_enzyme/_coenzyme0.49146118
120MP0002693_abnormal_pancreas_physiology0.46389722
121MP0000920_abnormal_myelination0.45641970

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.67261225
2Recurrent bacterial skin infections (HP:0005406)5.97057590
3Eczematoid dermatitis (HP:0000976)5.53651011
4Myositis (HP:0100614)4.36708346
5Gastrointestinal infarctions (HP:0005244)4.30865955
6IgM deficiency (HP:0002850)4.23360115
7Recurrent gram-negative bacterial infections (HP:0005420)4.22579720
8Elevated erythrocyte sedimentation rate (HP:0003565)4.20278035
9Chronic otitis media (HP:0000389)4.14980443
10Mediastinal lymphadenopathy (HP:0100721)3.97793213
11Recurrent fungal infections (HP:0002841)3.95066270
12Chronic obstructive pulmonary disease (HP:0006510)3.94954702
13Obstructive lung disease (HP:0006536)3.94954702
14Abnormality of macrophages (HP:0004311)3.90494577
15Recurrent skin infections (HP:0001581)3.86426031
16Thrombocytosis (HP:0001894)3.82936925
17Recurrent viral infections (HP:0004429)3.82143547
18Meningitis (HP:0001287)3.63499095
19Keratoconjunctivitis (HP:0001096)3.58441355
20Cellulitis (HP:0100658)3.53595680
21Hypochromic microcytic anemia (HP:0004840)3.51016160
22Petechiae (HP:0000967)3.39516573
23Vacuolated lymphocytes (HP:0001922)3.31997019
24Prolonged bleeding time (HP:0003010)3.26514688
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.22646209
26Vasculitis (HP:0002633)3.20588365
27Gingivitis (HP:0000230)3.16588495
28Orchitis (HP:0100796)3.16397466
29Increased cerebral lipofuscin (HP:0011813)3.11568020
30Spontaneous hematomas (HP:0007420)3.11238380
31Hypochromic anemia (HP:0001931)3.06921077
32Stomatitis (HP:0010280)3.06824933
33Panhypogammaglobulinemia (HP:0003139)3.04572901
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.03036940
35Abnormality of T cell physiology (HP:0011840)3.02000663
36Recurrent bronchitis (HP:0002837)3.00024898
37Recurrent cutaneous fungal infections (HP:0011370)2.96929307
38Chronic mucocutaneous candidiasis (HP:0002728)2.96929307
39Optic neuritis (HP:0100653)2.91237434
40Retrobulbar optic neuritis (HP:0100654)2.91237434
41Episodic fever (HP:0001954)2.91133874
42Abnormality of the prostate (HP:0008775)2.90821745
43Periodontitis (HP:0000704)2.89380309
44Epistaxis (HP:0000421)2.86117797
45Pulmonary embolism (HP:0002204)2.85980070
46Abnormality of T cells (HP:0002843)2.81680676
47Anorexia (HP:0002039)2.77601752
48Lymphopenia (HP:0001888)2.76512914
49Increased IgM level (HP:0003496)2.76298622
50Agammaglobulinemia (HP:0004432)2.76133724
51Peritonitis (HP:0002586)2.75442166
52Inflammation of the large intestine (HP:0002037)2.71623943
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.68079935
54Autoimmune thrombocytopenia (HP:0001973)2.67792506
55Gastrointestinal inflammation (HP:0004386)2.67202950
56Pustule (HP:0200039)2.66385976
57Amyloidosis (HP:0011034)2.58750338
58Gangrene (HP:0100758)2.55487152
59Osteomyelitis (HP:0002754)2.54985800
60Abnormality of the pleura (HP:0002103)2.53790628
61IgG deficiency (HP:0004315)2.52836964
62Aplastic anemia (HP:0001915)2.50396650
63Gingival bleeding (HP:0000225)2.47219880
64Impaired platelet aggregation (HP:0003540)2.46735683
65Abnormal platelet function (HP:0011869)2.46735683
66Encephalitis (HP:0002383)2.44854368
67Gastrointestinal stroma tumor (HP:0100723)2.44578809
68Agnosia (HP:0010524)2.43461531
69Recurrent pneumonia (HP:0006532)2.43050893
70Urticaria (HP:0001025)2.42485294
71B lymphocytopenia (HP:0010976)2.41424631
72Abnormality of B cell number (HP:0010975)2.41424631
73Leukocytosis (HP:0001974)2.39170219
74Reticulocytopenia (HP:0001896)2.36354888
75Chest pain (HP:0100749)2.36213404
76Nasal polyposis (HP:0100582)2.36159824
77Microcytic anemia (HP:0001935)2.34737595
78Hemoptysis (HP:0002105)2.34327471
79Arterial thrombosis (HP:0004420)2.33872558
80Pulmonary infiltrates (HP:0002113)2.33642918
81Colitis (HP:0002583)2.33419248
82T lymphocytopenia (HP:0005403)2.31964738
83Lymphoma (HP:0002665)2.29973292
84Abnormality of the peritoneum (HP:0002585)2.29653375
85Abnormality of T cell number (HP:0011839)2.28604924
86Interstitial pulmonary disease (HP:0006530)2.27158125
87Abnormal number of erythroid precursors (HP:0012131)2.26804560
88Abnormality of the nasal mucosa (HP:0000433)2.24714156
89Thyroiditis (HP:0100646)2.23983983
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23251136
91Glomerulopathy (HP:0100820)2.23195480
92Recurrent lower respiratory tract infections (HP:0002783)2.22958398
93Autoimmune hemolytic anemia (HP:0001890)2.20919158
94Hypergammaglobulinemia (HP:0010702)2.20124456
95Abnormality of cells of the erythroid lineage (HP:0012130)2.20057637
96Keratoconjunctivitis sicca (HP:0001097)2.18258984
97Eosinophilia (HP:0001880)2.16976749
98Loss of speech (HP:0002371)2.16339470
99Granulocytopenia (HP:0001913)2.15974392
100Sepsis (HP:0100806)2.14005642
101Increased IgE level (HP:0003212)2.13399300
102Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11645045
103Recurrent sinusitis (HP:0011108)2.11138062
104Abnormality of the endocardium (HP:0004306)2.10395548
105Vertigo (HP:0002321)2.09477464
106Poikiloderma (HP:0001029)2.08961882
107Acute myeloid leukemia (HP:0004808)2.08417511
108Skin ulcer (HP:0200042)2.07625566
109Reduced antithrombin III activity (HP:0001976)2.07103178
110Amaurosis fugax (HP:0100576)2.06832979
111IgA deficiency (HP:0002720)2.05745950
112Purpura (HP:0000979)2.03682955
113Abnormality of the fingertips (HP:0001211)2.03452143
114Neutropenia (HP:0001875)2.03439793
115Viral hepatitis (HP:0006562)2.03269438
116Acute hepatic failure (HP:0006554)2.02883747
117Slow saccadic eye movements (HP:0000514)2.02181203
118Abnormality of eosinophils (HP:0001879)2.01810339
119Keratitis (HP:0000491)2.01666013
120Chronic diarrhea (HP:0002028)2.01645217
121Skin rash (HP:0000988)2.00457675
122Papilledema (HP:0001085)1.98620450
123Dysostosis multiplex (HP:0000943)1.98566691
124Basal ganglia calcification (HP:0002135)1.98331521
125Albinism (HP:0001022)1.97795487
126Myelodysplasia (HP:0002863)1.97040820
127Abnormality of the pericardium (HP:0001697)1.96675944
128Polyneuropathy (HP:0001271)1.96246971
129Acne (HP:0001061)1.94594495
130Premature loss of primary teeth (HP:0006323)1.90750999
131Abnormal platelet volume (HP:0011876)1.88475864
132Thrombophlebitis (HP:0004418)1.88142394
133Joint swelling (HP:0001386)1.87892433
134Hepatosplenomegaly (HP:0001433)1.86529364
135Increased serum ferritin (HP:0003281)1.83406285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.43918283
2IRAK43.25634801
3KIT3.17610083
4TEC2.87825156
5BTK2.73491535
6TXK2.72062987
7BLK2.69917875
8RIPK42.22322457
9TYK22.18803912
10ZAP702.17479806
11PRPF4B2.15769482
12MAP3K142.11416916
13TBK12.04981102
14CSF1R2.03699710
15SYK1.97221403
16JAK31.88970890
17TAOK31.83867770
18FLT31.79574341
19MAP3K121.79415910
20IKBKE1.71658807
21FES1.71518859
22ERN11.68091377
23ITK1.64617994
24IRAK31.62557384
25STK101.59602805
26MAP2K31.56270634
27MAP3K31.55695277
28IKBKB1.47736312
29TAOK11.45219954
30LYN1.44577062
31HCK1.42872892
32CSK1.41782456
33CLK11.37853253
34NME21.35456731
35MATK1.34401000
36PIM21.32740928
37LCK1.30988488
38GRK61.29257946
39LRRK21.29082544
40PIM11.23722999
41BMPR21.22247409
42TGFBR21.21791895
43EEF2K1.18383567
44MAP3K11.18308578
45JAK11.17356083
46KSR21.16511311
47IRAK11.07881401
48STK161.02757990
49TRPM70.98408028
50EPHB10.98372993
51IRAK20.93705077
52KDR0.93502086
53PDK10.90450178
54RPS6KA40.88428144
55STK40.85657653
56VRK10.85593985
57TNK20.82006250
58CHUK0.81443040
59MAP3K130.80471596
60MARK20.79447062
61TGFBR10.77098749
62MAP3K20.76732106
63TESK20.76550659
64PKN20.76297228
65NEK20.76292590
66EIF2AK30.74452744
67CDK190.70056685
68JAK20.70010686
69PTK60.69430374
70FYN0.69258224
71PDPK10.69000721
72SIK30.68779830
73WEE10.67951876
74YES10.66551222
75PRKD20.66419535
76MAPK120.63831588
77PAK40.61828306
78ATR0.61779548
79MAPK70.61164861
80EIF2AK10.58981766
81PRKG20.58364918
82CAMKK20.57267367
83SIK20.57217262
84MAP3K50.56763365
85MAP3K70.56655099
86RPS6KA60.56337045
87NLK0.55980874
88MAPK40.55809553
89DYRK1B0.54015547
90GRK70.53461953
91ABL10.53158791
92STK240.52689482
93MARK30.52664773
94HIPK20.52653862
95TNIK0.52024132
96CDK70.51881607
97PTK2B0.50864179
98PRKCD0.50206265
99MAP2K40.49456685
100STK110.49429451
101CAMKK10.48887381
102ADRBK20.48461811
103CDK40.48225175
104EPHA30.47978846
105MAP3K110.46787848
106CDC70.46486286
107MAP2K60.46289941
108RAF10.45766071
109NEK90.45451839
110SGK30.45084139
111PRKCQ0.44125096
112FGFR30.43999078
113TRIB30.43722745
114RPS6KC10.43693494
115RPS6KL10.43693494
116EIF2AK20.43509677
117RPS6KB20.43289245
118TAOK20.42743065
119CDC42BPA0.41768435
120RET0.41055356
121CDK60.39408893
122ACVR1B0.37799163
123FGFR40.36492622
124PIK3CG0.36372344
125BRD40.36084527
126MAPKAPK20.35834199
127MAP3K80.35047370
128SMG10.34772452
129MST40.34046592
130KSR10.33292255
131MAP3K60.32762713
132SGK20.31860863
133STK380.31315695
134DAPK20.31210557
135SCYL20.31126684
136BRSK20.31089167
137WNK10.30918127
138MAPK110.30282537
139FGR0.30043090

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.06073358
2Primary immunodeficiency_Homo sapiens_hsa053402.84567601
3B cell receptor signaling pathway_Homo sapiens_hsa046622.39785584
4DNA replication_Homo sapiens_hsa030302.39532196
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27307804
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.24282404
7Osteoclast differentiation_Homo sapiens_hsa043802.12491101
8Measles_Homo sapiens_hsa051622.12477796
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.09393468
10Hematopoietic cell lineage_Homo sapiens_hsa046402.07511821
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04803054
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01708697
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01242834
14Staphylococcus aureus infection_Homo sapiens_hsa051502.00204111
15Antigen processing and presentation_Homo sapiens_hsa046121.95400079
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89520030
17Asthma_Homo sapiens_hsa053101.89452015
18Ribosome_Homo sapiens_hsa030101.84861928
19Herpes simplex infection_Homo sapiens_hsa051681.83339845
20Allograft rejection_Homo sapiens_hsa053301.81579424
21Legionellosis_Homo sapiens_hsa051341.76064496
22Other glycan degradation_Homo sapiens_hsa005111.69591477
23Mismatch repair_Homo sapiens_hsa034301.68992811
24Pertussis_Homo sapiens_hsa051331.68853570
25Base excision repair_Homo sapiens_hsa034101.64931665
26Graft-versus-host disease_Homo sapiens_hsa053321.63197634
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59279269
28Tuberculosis_Homo sapiens_hsa051521.58464907
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53331167
30Malaria_Homo sapiens_hsa051441.51213168
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50894784
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.46570683
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.43836450
34Shigellosis_Homo sapiens_hsa051311.43575921
35Influenza A_Homo sapiens_hsa051641.42488628
36Homologous recombination_Homo sapiens_hsa034401.38128157
37Toxoplasmosis_Homo sapiens_hsa051451.35715895
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26347100
39Hepatitis B_Homo sapiens_hsa051611.24218459
40Salmonella infection_Homo sapiens_hsa051321.23436794
41Caffeine metabolism_Homo sapiens_hsa002321.22884183
42Chemokine signaling pathway_Homo sapiens_hsa040621.21115849
43T cell receptor signaling pathway_Homo sapiens_hsa046601.20564434
44Lysosome_Homo sapiens_hsa041421.19272385
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.17340069
46Apoptosis_Homo sapiens_hsa042101.16470371
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12070210
48Platelet activation_Homo sapiens_hsa046111.09735794
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09463866
50Acute myeloid leukemia_Homo sapiens_hsa052211.08600119
51TNF signaling pathway_Homo sapiens_hsa046681.06523260
52Viral myocarditis_Homo sapiens_hsa054161.05898824
53Non-homologous end-joining_Homo sapiens_hsa034501.03076033
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94413399
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93493411
56Epstein-Barr virus infection_Homo sapiens_hsa051690.92225688
57Spliceosome_Homo sapiens_hsa030400.88992765
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87804977
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86216462
60Nucleotide excision repair_Homo sapiens_hsa034200.85898186
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84479750
62Phagosome_Homo sapiens_hsa041450.84077261
63Pyrimidine metabolism_Homo sapiens_hsa002400.82536287
64Renal cell carcinoma_Homo sapiens_hsa052110.79694072
65African trypanosomiasis_Homo sapiens_hsa051430.77846157
66Hepatitis C_Homo sapiens_hsa051600.76343153
67Rheumatoid arthritis_Homo sapiens_hsa053230.75177170
68Pentose phosphate pathway_Homo sapiens_hsa000300.74815272
69Fanconi anemia pathway_Homo sapiens_hsa034600.73836984
70Pancreatic cancer_Homo sapiens_hsa052120.72926051
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72249092
72Autoimmune thyroid disease_Homo sapiens_hsa053200.71138715
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70976493
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70471262
75Endocytosis_Homo sapiens_hsa041440.70203293
76Chronic myeloid leukemia_Homo sapiens_hsa052200.70201789
77Viral carcinogenesis_Homo sapiens_hsa052030.70187283
78p53 signaling pathway_Homo sapiens_hsa041150.69913532
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66863999
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66472431
81Cell cycle_Homo sapiens_hsa041100.66341305
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64939018
83Type I diabetes mellitus_Homo sapiens_hsa049400.62746912
84FoxO signaling pathway_Homo sapiens_hsa040680.62272836
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60865979
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.59819400
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59562086
88N-Glycan biosynthesis_Homo sapiens_hsa005100.59403822
89RNA polymerase_Homo sapiens_hsa030200.59345840
90Dorso-ventral axis formation_Homo sapiens_hsa043200.58146248
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58031510
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55676334
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.54742060
94RNA degradation_Homo sapiens_hsa030180.54651567
95Amoebiasis_Homo sapiens_hsa051460.53356019
96Choline metabolism in cancer_Homo sapiens_hsa052310.52579950
97GnRH signaling pathway_Homo sapiens_hsa049120.52533249
98Endometrial cancer_Homo sapiens_hsa052130.52285451
99HTLV-I infection_Homo sapiens_hsa051660.50017535
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.49074156
101Regulation of autophagy_Homo sapiens_hsa041400.48797589
102Proteasome_Homo sapiens_hsa030500.48659675
103HIF-1 signaling pathway_Homo sapiens_hsa040660.47798445
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46664037
105Colorectal cancer_Homo sapiens_hsa052100.45908594
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45758062
107Systemic lupus erythematosus_Homo sapiens_hsa053220.45390346
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45333070
109Inositol phosphate metabolism_Homo sapiens_hsa005620.44028020
110mTOR signaling pathway_Homo sapiens_hsa041500.43381640
111Renin-angiotensin system_Homo sapiens_hsa046140.43271689
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43176045
113Insulin resistance_Homo sapiens_hsa049310.42842810
114MAPK signaling pathway_Homo sapiens_hsa040100.42723001
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42407739
116Non-small cell lung cancer_Homo sapiens_hsa052230.42271141
117Small cell lung cancer_Homo sapiens_hsa052220.37558697
118Type II diabetes mellitus_Homo sapiens_hsa049300.36142142
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.35705041
120Rap1 signaling pathway_Homo sapiens_hsa040150.34860397
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.33338649
122ErbB signaling pathway_Homo sapiens_hsa040120.33066557
123VEGF signaling pathway_Homo sapiens_hsa043700.31769770
124Protein export_Homo sapiens_hsa030600.31329030
125Prostate cancer_Homo sapiens_hsa052150.31279716
126Prolactin signaling pathway_Homo sapiens_hsa049170.30468755
127Notch signaling pathway_Homo sapiens_hsa043300.28925518
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28096286
129RNA transport_Homo sapiens_hsa030130.26822293

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