EVC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)8.14771510
2drug transmembrane transport (GO:0006855)6.66810525
3urate metabolic process (GO:0046415)6.31503060
4phosphate ion transport (GO:0006817)5.59961008
5drug transport (GO:0015893)5.51186050
6metanephric nephron tubule development (GO:0072234)5.38979506
7metanephric tubule development (GO:0072170)5.38979506
8organic cation transport (GO:0015695)5.20202785
9lysine catabolic process (GO:0006554)5.02226742
10lysine metabolic process (GO:0006553)5.02226742
11protein heterotrimerization (GO:0070208)4.99932210
12skin morphogenesis (GO:0043589)4.95464777
13metanephric nephron epithelium development (GO:0072243)4.84316352
14phosphate ion transmembrane transport (GO:0035435)4.58532567
15metanephric epithelium development (GO:0072207)4.48136152
16nephron tubule development (GO:0072080)4.38961377
17cell adhesion mediated by integrin (GO:0033627)4.24124255
18quaternary ammonium group transport (GO:0015697)4.23223488
19nephron epithelium morphogenesis (GO:0072088)4.20350044
20nephron tubule morphogenesis (GO:0072078)4.20350044
21renal absorption (GO:0070293)4.18550370
22excretion (GO:0007588)4.17781489
23hemidesmosome assembly (GO:0031581)4.15144043
24metanephric mesenchyme development (GO:0072075)4.09301266
25planar cell polarity pathway involved in neural tube closure (GO:0090179)4.06701759
26renal tubule morphogenesis (GO:0061333)4.03793094
27cell migration involved in heart development (GO:0060973)4.01210728
28paraxial mesoderm development (GO:0048339)3.99537317
29collagen fibril organization (GO:0030199)3.98710810
30extracellular matrix assembly (GO:0085029)3.98184409
31phosphate ion homeostasis (GO:0055062)3.97467345
32trivalent inorganic anion homeostasis (GO:0072506)3.97467345
33renal tubule development (GO:0061326)3.85582475
34chondrocyte proliferation (GO:0035988)3.84278215
35cell-substrate junction assembly (GO:0007044)3.83612303
36vascular endothelial growth factor signaling pathway (GO:0038084)3.80499396
37exocrine pancreas development (GO:0031017)3.80348514
38exogenous drug catabolic process (GO:0042738)3.77832090
39kidney mesenchyme development (GO:0072074)3.76935894
40tricarboxylic acid metabolic process (GO:0072350)3.76336982
41cellular response to vitamin D (GO:0071305)3.75590357
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.75079091
43extracellular fibril organization (GO:0043206)3.70054942
44glomerular basement membrane development (GO:0032836)3.68545295
45drug catabolic process (GO:0042737)3.65867780
46toxin transport (GO:1901998)3.63353564
47proline metabolic process (GO:0006560)3.63044601
48sequestering of extracellular ligand from receptor (GO:0035581)3.61458357
49response to mercury ion (GO:0046689)3.61064647
50keratan sulfate catabolic process (GO:0042340)3.60898419
51nephron epithelium development (GO:0072009)3.59597543
52neuron projection extension involved in neuron projection guidance (GO:1902284)3.59466071
53axon extension involved in axon guidance (GO:0048846)3.59466071
54cellular response to vitamin (GO:0071295)3.57506815
55regulation of hippo signaling (GO:0035330)3.54121954
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.49620975
57type B pancreatic cell proliferation (GO:0044342)3.47392804
58mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.46480165
59glyoxylate metabolic process (GO:0046487)3.44605889
60bone remodeling (GO:0046849)3.44115100
61cell migration involved in sprouting angiogenesis (GO:0002042)3.43712969
62negative regulation of fatty acid transport (GO:2000192)3.43145706
63substrate-dependent cell migration (GO:0006929)3.40518073
64extracellular matrix disassembly (GO:0022617)3.35216800
65mesenchymal-epithelial cell signaling (GO:0060638)3.34307730
66homocysteine metabolic process (GO:0050667)3.31375486
67adhesion of symbiont to host cell (GO:0044650)3.30646834
68virion attachment to host cell (GO:0019062)3.30646834
69bone trabecula formation (GO:0060346)3.30493538
70endothelial cell morphogenesis (GO:0001886)3.29951200
71vitamin D metabolic process (GO:0042359)3.29531730
72retina vasculature morphogenesis in camera-type eye (GO:0061299)3.29435864
73insulin-like growth factor receptor signaling pathway (GO:0048009)3.27823361
74positive regulation of blood vessel endothelial cell migration (GO:0043536)3.26421451
75regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.26262535
76fibril organization (GO:0097435)3.25963414
77collecting duct development (GO:0072044)3.24746144
78hypotonic response (GO:0006971)3.17462423
79endocardial cushion development (GO:0003197)3.17267329
80response to parathyroid hormone (GO:0071107)3.16190074
81protein localization to endosome (GO:0036010)3.15235610
82outer ear morphogenesis (GO:0042473)3.13519278
83adhesion of symbiont to host (GO:0044406)3.13272895
84adherens junction assembly (GO:0034333)3.11937972
85negative regulation of smooth muscle cell migration (GO:0014912)3.10774547
86aspartate family amino acid catabolic process (GO:0009068)3.10142157
87G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.08380110
88venous blood vessel morphogenesis (GO:0048845)3.08202189
89hippo signaling (GO:0035329)3.06954285
90branched-chain amino acid metabolic process (GO:0009081)3.06327375
91wound healing, spreading of epidermal cells (GO:0035313)3.05579085
92dermatan sulfate biosynthetic process (GO:0030208)3.05304339
93dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.04838380
94apoptotic cell clearance (GO:0043277)3.03166729
95positive regulation of endothelial cell apoptotic process (GO:2000353)3.02332615
96negative regulation of chondrocyte differentiation (GO:0032331)2.99905086
97regulation of apoptotic process involved in morphogenesis (GO:1902337)2.99870322
98response to magnesium ion (GO:0032026)2.99566830
99carnitine transport (GO:0015879)2.99137756
100amino-acid betaine transport (GO:0015838)2.99137756
101nephron tubule formation (GO:0072079)2.98693570
102endothelial cell chemotaxis (GO:0035767)2.98204422
103cell-substrate adherens junction assembly (GO:0007045)2.96324266
104focal adhesion assembly (GO:0048041)2.96324266
105extracellular matrix organization (GO:0030198)2.94081559
106blood vessel maturation (GO:0001955)2.93525406
107extracellular structure organization (GO:0043062)2.92959688
108Golgi transport vesicle coating (GO:0048200)2.92066809
109COPI coating of Golgi vesicle (GO:0048205)2.92066809
110valine metabolic process (GO:0006573)2.90607704
111peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.86535018
112cochlea morphogenesis (GO:0090103)2.86307232
113substrate adhesion-dependent cell spreading (GO:0034446)2.85670144
114pericardium development (GO:0060039)2.85123555
115short-chain fatty acid metabolic process (GO:0046459)2.84677681
116endodermal cell differentiation (GO:0035987)2.84152690
117lateral sprouting from an epithelium (GO:0060601)2.83859217
118vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.83690848
119positive regulation of respiratory burst (GO:0060267)2.83079457
120embryonic cranial skeleton morphogenesis (GO:0048701)2.82901350
121smooth muscle tissue development (GO:0048745)2.81833711
122regulation of axon extension involved in axon guidance (GO:0048841)2.81659610
123embryonic skeletal joint morphogenesis (GO:0060272)2.81353861
124collagen metabolic process (GO:0032963)2.80742197
125protein retention in ER lumen (GO:0006621)2.80472961
126Notch signaling involved in heart development (GO:0061314)2.80322952
127collagen catabolic process (GO:0030574)2.78951716
128heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.78795318
129mesodermal cell differentiation (GO:0048333)2.78682999
130negative regulation of osteoblast proliferation (GO:0033689)2.78235546
131blood vessel endothelial cell migration (GO:0043534)2.76381769
132regulation of extracellular matrix disassembly (GO:0010715)2.75794753
133cell proliferation involved in metanephros development (GO:0072203)2.74314359
134maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73263498
135basement membrane organization (GO:0071711)2.72858087
136dermatan sulfate metabolic process (GO:0030205)2.71450434
137cysteine metabolic process (GO:0006534)2.70755299
138stress fiber assembly (GO:0043149)2.70011886
139cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.69240422
140regulation of plasminogen activation (GO:0010755)2.69008787
141regulation of establishment of planar polarity (GO:0090175)2.68888462
142multicellular organismal macromolecule metabolic process (GO:0044259)2.68402676
143epithelial cell-cell adhesion (GO:0090136)2.68045844
144cell surface receptor signaling pathway involved in heart development (GO:0061311)2.67907689
145chondrocyte development (GO:0002063)2.65386608
146semaphorin-plexin signaling pathway (GO:0071526)2.63670871
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.61969540
148actin filament depolymerization (GO:0030042)2.61577909
149positive regulation of osteoblast proliferation (GO:0033690)2.61067179
150peptide catabolic process (GO:0043171)2.60867482
151regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.59572150
152multicellular organismal metabolic process (GO:0044236)2.59285544
153positive regulation of catenin import into nucleus (GO:0035413)2.59268128
154peptidyl-proline hydroxylation (GO:0019511)2.58920917
155tooth mineralization (GO:0034505)2.58734671
156multicellular organismal catabolic process (GO:0044243)2.58375703
157barbed-end actin filament capping (GO:0051016)2.58133220
158muscle cell migration (GO:0014812)2.55892563
159cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.55342879
160protein localization to cell surface (GO:0034394)2.55102686
161establishment of planar polarity (GO:0001736)2.54981013
162establishment of tissue polarity (GO:0007164)2.54981013
163Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54838058
164regulation of heart morphogenesis (GO:2000826)2.54160683
165regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54037004
166positive regulation of extracellular matrix organization (GO:1903055)2.54030985
1672-oxoglutarate metabolic process (GO:0006103)2.53150872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.76054702
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.35267568
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.76519859
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.25368308
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.85781127
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.84590073
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.81136546
8* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.79668406
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.61691392
10CLOCK_20551151_ChIP-Seq_293T_Human2.41034862
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.33393419
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.29572161
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.17334109
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16641706
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.14387808
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.10013143
17TP53_20018659_ChIP-ChIP_R1E_Mouse2.06599598
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05264755
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04462752
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.01380036
21CJUN_26792858_Chip-Seq_BT549_Human1.96932918
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.91109605
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88724214
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87158324
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87158324
26NFIB_24661679_ChIP-Seq_LUNG_Mouse1.77319492
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77258562
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.74427506
29AR_21909140_ChIP-Seq_LNCAP_Human1.74078787
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.70602658
31GBX2_23144817_ChIP-Seq_PC3_Human1.69959997
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.68940869
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68332859
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68132828
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65252434
36* TP53_22127205_ChIP-Seq_IMR90_Human1.64260925
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63461884
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57887853
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.56618667
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55687696
41* TP53_18474530_ChIP-ChIP_U2OS_Human1.50900495
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50850404
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50773967
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49647677
45* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48856678
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47891196
47JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46955909
48BRD4_25478319_ChIP-Seq_HGPS_Human1.46939614
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.45119730
50AR_21572438_ChIP-Seq_LNCaP_Human1.42087693
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41418009
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40829485
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.40618511
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.39985927
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38186823
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.35905761
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35213493
58TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.33930175
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33467486
60SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32185043
61KDM2B_26808549_Chip-Seq_K562_Human1.30745368
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30267996
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29661790
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29330708
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.28084526
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27531687
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27476669
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26939698
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.26888289
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26736288
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25738814
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24015036
73LXR_22292898_ChIP-Seq_THP-1_Human1.22776274
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22244652
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22244652
76NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22084043
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21267676
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.19084059
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18998964
80AHR_22903824_ChIP-Seq_MCF-7_Human1.18877768
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.18169118
82SMC3_22415368_ChIP-Seq_MEFs_Mouse1.18148051
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17958036
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17735188
85DROSHA_22980978_ChIP-Seq_HELA_Human1.17552217
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17512657
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16668934
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16650517
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16401546
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13101601
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.12734725
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.12734725
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12426201
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10107315
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09525334
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09309980
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08468255
98RACK7_27058665_Chip-Seq_MCF-7_Human1.08236805
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07759093
100SA1_22415368_ChIP-Seq_MEFs_Mouse1.06896088
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.06047673
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04484644
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04184982
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04184982
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04184982
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03751746
107TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03172825
108P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02989669
109TP53_23651856_ChIP-Seq_MEFs_Mouse1.02628883
110GATA1_22025678_ChIP-Seq_K562_Human1.02042858
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.01933191
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01588368
113TP53_16413492_ChIP-PET_HCT116_Human1.01453212
114PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01033710
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00860413
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00860413
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00538727
118EGR1_19374776_ChIP-ChIP_THP-1_Human1.00201187
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99986981
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.99297103
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98288980
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97802581
123RNF2_27304074_Chip-Seq_ESCs_Mouse0.96541428
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95460912
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.95281584
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95109221
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94840098
128ATF3_27146783_Chip-Seq_COLON_Human0.94002171
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.93966069
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.93602803
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93584240
132FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93512585
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92140063
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91982855
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91805869
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.91804714
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90798985
138FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90098440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.64025258
2MP0005503_abnormal_tendon_morphology5.37672842
3MP0005275_abnormal_skin_tensile4.05446165
4MP0001958_emphysema3.70412272
5MP0003705_abnormal_hypodermis_morpholog2.86871816
6MP0010368_abnormal_lymphatic_system2.80710114
7MP0004043_abnormal_pH_regulation2.72471989
8MP0002138_abnormal_hepatobiliary_system2.57614050
9MP0005360_urolithiasis2.53830274
10MP0010030_abnormal_orbit_morphology2.51985949
11MP0005623_abnormal_meninges_morphology2.40035031
12MP0004019_abnormal_vitamin_homeostasis2.35744560
13MP0004272_abnormal_basement_membrane2.34087797
14MP0002108_abnormal_muscle_morphology2.29003929
15MP0005332_abnormal_amino_acid2.16359147
16MP0003950_abnormal_plasma_membrane2.07097705
17MP0005257_abnormal_intraocular_pressure2.03770049
18MP0005084_abnormal_gallbladder_morpholo2.03075589
19MP0003195_calcinosis1.99417401
20MP0003283_abnormal_digestive_organ1.92250405
21MP0001542_abnormal_bone_strength1.90212711
22MP0005377_hearing/vestibular/ear_phenot1.86050107
23MP0003878_abnormal_ear_physiology1.86050107
24MP0003385_abnormal_body_wall1.86002209
25MP0003279_aneurysm1.85456603
26MP0005508_abnormal_skeleton_morphology1.82991521
27MP0003252_abnormal_bile_duct1.82875888
28MP0002877_abnormal_melanocyte_morpholog1.82316681
29MP0002249_abnormal_larynx_morphology1.75161781
30MP0009643_abnormal_urine_homeostasis1.73843167
31MP0004858_abnormal_nervous_system1.73298945
32MP0003941_abnormal_skin_development1.67243480
33MP0001756_abnormal_urination1.66336677
34MP0002896_abnormal_bone_mineralization1.64921430
35MP0002136_abnormal_kidney_physiology1.61406879
36MP0001765_abnormal_ion_homeostasis1.57220165
37MP0002168_other_aberrant_phenotype1.55166411
38MP0009250_abnormal_appendicular_skeleto1.52874508
39MP0000537_abnormal_urethra_morphology1.52629173
40MP0002089_abnormal_postnatal_growth/wei1.47511718
41MP0002928_abnormal_bile_duct1.47267428
42MP0000534_abnormal_ureter_morphology1.46176122
43MP0000751_myopathy1.45452730
44MP0003942_abnormal_urinary_system1.37605764
45MP0002282_abnormal_trachea_morphology1.37540098
46MP0000013_abnormal_adipose_tissue1.37398408
47MP0000538_abnormal_urinary_bladder1.37254159
48MP0000733_abnormal_muscle_development1.35949325
49MP0001293_anophthalmia1.30108690
50* MP0000163_abnormal_cartilage_morphology1.29853087
51* MP0002115_abnormal_skeleton_extremities1.29276226
52MP0002932_abnormal_joint_morphology1.26215382
53MP0001879_abnormal_lymphatic_vessel1.22803037
54MP0001849_ear_inflammation1.18739554
55MP0009384_cardiac_valve_regurgitation1.17034783
56MP0005171_absent_coat_pigmentation1.16729553
57MP0002060_abnormal_skin_morphology1.16352080
58MP0000566_synostosis1.16321131
59MP0004233_abnormal_muscle_weight1.16302877
60MP0009053_abnormal_anal_canal1.15495341
61MP0009780_abnormal_chondrocyte_physiolo1.15187429
62MP0006054_spinal_hemorrhage1.15063660
63MP0003566_abnormal_cell_adhesion1.13830853
64MP0000762_abnormal_tongue_morphology1.12940694
65MP0005595_abnormal_vascular_smooth1.12696398
66MP0001348_abnormal_lacrimal_gland1.12550362
67MP0005409_darkened_coat_color1.12014741
68MP0010352_gastrointestinal_tract_polyps1.10017708
69MP0005197_abnormal_uvea_morphology1.07756369
70MP0003755_abnormal_palate_morphology1.07269266
71MP0005670_abnormal_white_adipose1.07197086
72MP0003938_abnormal_ear_development1.06232601
73MP0003937_abnormal_limbs/digits/tail_de1.05884237
74MP0000428_abnormal_craniofacial_morphol1.05614222
75MP0000049_abnormal_middle_ear1.04364798
76MP0003300_gastrointestinal_ulcer1.04361345
77MP0005636_abnormal_mineral_homeostasis1.01024324
78MP0000003_abnormal_adipose_tissue1.00236076
79* MP0002113_abnormal_skeleton_development0.99082759
80MP0005076_abnormal_cell_differentiation0.98629546
81MP0001270_distended_abdomen0.97091319
82MP0002139_abnormal_hepatobiliary_system0.96797586
83MP0003115_abnormal_respiratory_system0.96290261
84MP0000749_muscle_degeneration0.96106695
85MP0000759_abnormal_skeletal_muscle0.93773540
86MP0005248_abnormal_Harderian_gland0.93578467
87MP0003123_paternal_imprinting0.93050319
88MP0002135_abnormal_kidney_morphology0.92498519
89MP0003045_fibrosis0.92412418
90* MP0000432_abnormal_head_morphology0.91178599
91* MP0002109_abnormal_limb_morphology0.87461096
92MP0001915_intracranial_hemorrhage0.87187458
93* MP0002116_abnormal_craniofacial_bone0.86791919
94MP0002128_abnormal_blood_circulation0.86005558
95MP0005023_abnormal_wound_healing0.85226249
96MP0002697_abnormal_eye_size0.84651638
97MP0001614_abnormal_blood_vessel0.84403890
98MP0000678_abnormal_parathyroid_gland0.83644922
99MP0004084_abnormal_cardiac_muscle0.82849535
100MP0003091_abnormal_cell_migration0.82801926
101MP0008961_abnormal_basal_metabolism0.82536657
102MP0003935_abnormal_craniofacial_develop0.82467093
103MP0003122_maternal_imprinting0.81916348
104MP0010386_abnormal_urinary_bladder0.81792024
105MP0002092_abnormal_eye_morphology0.80794540
106MP0004134_abnormal_chest_morphology0.78979179
107MP0006138_congestive_heart_failure0.78808136
108MP0002933_joint_inflammation0.78683526
109MP0002876_abnormal_thyroid_physiology0.78367610
110MP0002295_abnormal_pulmonary_circulatio0.77847874
111MP0002938_white_spotting0.76288941
112MP0005164_abnormal_response_to0.75987384
113MP0003315_abnormal_perineum_morphology0.75434573
114MP0000767_abnormal_smooth_muscle0.75223988
115MP0000750_abnormal_muscle_regeneration0.74937180
116MP0000467_abnormal_esophagus_morphology0.74635553
117MP0002925_abnormal_cardiovascular_devel0.74338245
118MP0000462_abnormal_digestive_system0.73578738
119MP0001299_abnormal_eye_distance/0.73550331
120MP0004133_heterotaxia0.73428370
121MP0005666_abnormal_adipose_tissue0.73214532
122* MP0002114_abnormal_axial_skeleton0.73074683
123MP0002233_abnormal_nose_morphology0.70664771
124MP0009840_abnormal_foam_cell0.69948108
125MP0002111_abnormal_tail_morphology0.68101457
126MP0002998_abnormal_bone_remodeling0.67647668
127MP0005193_abnormal_anterior_eye0.67600501
128MP0005058_abnormal_lysosome_morphology0.67408472
129MP0001243_abnormal_dermal_layer0.65137665
130MP0001175_abnormal_lung_morphology0.64849999
131MP0001177_atelectasis0.64661770
132MP0002102_abnormal_ear_morphology0.64470432
133MP0004087_abnormal_muscle_fiber0.64283790
134MP0000371_diluted_coat_color0.63801564
135MP0005390_skeleton_phenotype0.62917617
136MP0009703_decreased_birth_body0.62875146
137MP0003795_abnormal_bone_structure0.62540383
138MP0002177_abnormal_outer_ear0.58861591
139MP0005388_respiratory_system_phenotype0.58705896
140MP0002133_abnormal_respiratory_system0.58705896
141MP0003448_altered_tumor_morphology0.58265793
142MP0004036_abnormal_muscle_relaxation0.57119244
143MP0005369_muscle_phenotype0.55873104

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)5.56864049
2Metabolic alkalosis (HP:0200114)5.36248712
3Hypokalemic alkalosis (HP:0001949)5.17323874
4Polyuria (HP:0000103)4.95068523
5Hypomagnesemia (HP:0002917)4.87447917
6Hyperactive renin-angiotensin system (HP:0000841)4.64359073
7Protrusio acetabuli (HP:0003179)4.58356238
8Abnormal urine output (HP:0012590)4.58202245
9Vascular tortuosity (HP:0004948)4.43711550
10Abnormality of renal excretion (HP:0011036)4.26406098
11Gout (HP:0001997)4.16812197
12Premature rupture of membranes (HP:0001788)4.15615988
13Abnormality of chloride homeostasis (HP:0011422)4.05924597
14Arterial tortuosity (HP:0005116)4.00529489
15Abnormality of magnesium homeostasis (HP:0004921)3.94440133
16Abnormal drinking behavior (HP:0030082)3.90371454
17Polydipsia (HP:0001959)3.90371454
18Wormian bones (HP:0002645)3.57666959
19Ankle contracture (HP:0006466)3.48141613
20Vertebral compression fractures (HP:0002953)3.47109482
21Tetany (HP:0001281)3.44773306
22Hypercalciuria (HP:0002150)3.36670300
23Proximal tubulopathy (HP:0000114)3.30042623
24Cervical subluxation (HP:0003308)3.26755283
25Increased purine levels (HP:0004368)3.21139216
26Hyperuricemia (HP:0002149)3.21139216
27Hyperaldosteronism (HP:0000859)3.16973950
28Abnormality of renin-angiotensin system (HP:0000847)3.16070934
29Renal salt wasting (HP:0000127)3.12473572
30Type 1 muscle fiber predominance (HP:0003803)3.10058563
31Genu recurvatum (HP:0002816)3.08495797
32Shallow orbits (HP:0000586)3.04374390
33Renal tubular acidosis (HP:0001947)3.03835866
34Spondylolisthesis (HP:0003302)3.01624440
35Hypokalemia (HP:0002900)2.99515892
36Follicular hyperkeratosis (HP:0007502)2.94510444
37Alkalosis (HP:0001948)2.89325704
38Abnormality of glutamine family amino acid metabolism (HP:0010902)2.86718860
39Biconcave vertebral bodies (HP:0004586)2.85856166
40Aortic regurgitation (HP:0001659)2.79372564
41Aortic dissection (HP:0002647)2.76578800
42* Neonatal short-limb short stature (HP:0008921)2.76308866
43Thin bony cortex (HP:0002753)2.75859044
44Peritonitis (HP:0002586)2.70894520
45Joint laxity (HP:0001388)2.69336957
46Bowel diverticulosis (HP:0005222)2.67438307
47Cardiovascular calcification (HP:0011915)2.67068926
48Hip contracture (HP:0003273)2.66810011
49Broad metatarsal (HP:0001783)2.63198454
50Overgrowth (HP:0001548)2.63083618
51Increased variability in muscle fiber diameter (HP:0003557)2.61809748
52Osteolytic defects of the hand bones (HP:0009699)2.60883256
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.60883256
54Soft skin (HP:0000977)2.60138023
55Hyperextensible skin (HP:0000974)2.59957410
56Ketoacidosis (HP:0001993)2.59614637
57Ulnar bowing (HP:0003031)2.55836154
58Spinal rigidity (HP:0003306)2.52371753
59Bladder diverticulum (HP:0000015)2.51367120
60Hyperglycinuria (HP:0003108)2.50557496
61Short 4th metacarpal (HP:0010044)2.46975008
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46975008
63Mitral regurgitation (HP:0001653)2.46407178
64Abnormality of purine metabolism (HP:0004352)2.46121127
65Atrophic scars (HP:0001075)2.43886434
66Aneurysm (HP:0002617)2.39368138
67Elbow flexion contracture (HP:0002987)2.39284774
68Abnormality of the acetabulum (HP:0003170)2.38998581
69Abnormality of potassium homeostasis (HP:0011042)2.38683642
70Lymphangioma (HP:0100764)2.38442032
71Short nail (HP:0001799)2.37003009
72Elfin facies (HP:0004428)2.36678283
73Vascular calcification (HP:0004934)2.35356535
74Increased connective tissue (HP:0009025)2.35102511
75Delayed epiphyseal ossification (HP:0002663)2.33603230
76Mitral stenosis (HP:0001718)2.31437420
77Nephrocalcinosis (HP:0000121)2.31037356
78Metaphyseal cupping (HP:0003021)2.28944570
79Abnormality of dentin (HP:0010299)2.27577837
80Hydroxyprolinuria (HP:0003080)2.22519993
81Abnormality of proline metabolism (HP:0010907)2.22519993
82Aortic aneurysm (HP:0004942)2.21733856
83Abnormal delivery (HP:0001787)2.20720283
84Enlarged kidneys (HP:0000105)2.18606307
85Slender build (HP:0001533)2.17451276
86Disproportionate tall stature (HP:0001519)2.16137455
87* Advanced eruption of teeth (HP:0006288)2.14543131
88Abnormality of skeletal muscle fiber size (HP:0012084)2.14005288
89Camptodactyly of toe (HP:0001836)2.11304943
90Hypoventilation (HP:0002791)2.07531389
91Aortic valve stenosis (HP:0001650)2.06570673
92Mesomelia (HP:0003027)2.06305713
93Ileus (HP:0002595)2.05975622
94Limited hip movement (HP:0008800)2.05919238
95Abnormal ossification of hand bones (HP:0005921)2.05572657
96Enlarged penis (HP:0000040)2.05351264
97Tubular atrophy (HP:0000092)2.05103752
98Round ear (HP:0100830)2.03771634
99Abnormality of serine family amino acid metabolism (HP:0010894)2.03565136
100Abnormality of glycine metabolism (HP:0010895)2.03565136
101Absent frontal sinuses (HP:0002688)2.03246886
102Hyperacusis (HP:0010780)2.02346208
103Ectopia lentis (HP:0001083)2.02180069
104Joint stiffness (HP:0001387)1.97917133
105Rickets (HP:0002748)1.97862823
106Coronal craniosynostosis (HP:0004440)1.95976350
107Protruding ear (HP:0000411)1.95855835
108Knee flexion contracture (HP:0006380)1.95847799
109Blue sclerae (HP:0000592)1.95439391
110Hypoplasia of the iris (HP:0007676)1.94502065
111Abnormality of carpal bone ossification (HP:0006257)1.92785457
112Cerebral aneurysm (HP:0004944)1.92646013
113Broad face (HP:0000283)1.91330582
114Wide anterior fontanel (HP:0000260)1.91121174
115Abnormality of sodium homeostasis (HP:0010931)1.90410016
116Hypophosphatemic rickets (HP:0004912)1.90134204
117Wide cranial sutures (HP:0010537)1.88650821
118Generalized aminoaciduria (HP:0002909)1.88513606
119Nephrolithiasis (HP:0000787)1.87929274
120Abnormality of the 4th metacarpal (HP:0010012)1.87846161
121Spinal cord lesions (HP:0100561)1.87158228
122Syringomyelia (HP:0003396)1.87158228
123Femoral bowing (HP:0002980)1.87065075
124Bicornuate uterus (HP:0000813)1.86979318
125Mitral valve prolapse (HP:0001634)1.86839843
126Fragile skin (HP:0001030)1.85975153
127Mildly elevated creatine phosphokinase (HP:0008180)1.85756898
128Tibial bowing (HP:0002982)1.85551210
129Long toe (HP:0010511)1.85502344
130Bilateral sensorineural hearing impairment (HP:0008619)1.84487975
131Inguinal hernia (HP:0000023)1.84333936
132Widely patent fontanelles and sutures (HP:0004492)1.82913489
133Persistence of primary teeth (HP:0006335)1.82583372
134Wrist flexion contracture (HP:0001239)1.81921255
135Hypophosphatemia (HP:0002148)1.81525946
136Dilatation of the ascending aorta (HP:0005111)1.81163533
137Hepatoblastoma (HP:0002884)1.80762751
138Delayed cranial suture closure (HP:0000270)1.80683599
139Metaphyseal dysplasia (HP:0100255)1.79652068
140Coxa vara (HP:0002812)1.79217992
141Abnormality of Sharpey fibers (HP:0100685)1.78599883
142Chondrocalcinosis (HP:0000934)1.78582779
143Broad ribs (HP:0000885)1.77066520
144Generalized muscle weakness (HP:0003324)1.77066511
145Generalized amyotrophy (HP:0003700)1.75912502
146Breech presentation (HP:0001623)1.75718221
147Delayed closure of the anterior fontanelle (HP:0001476)1.75690687
148Infantile muscular hypotonia (HP:0008947)1.75103178
149Deviation of the hallux (HP:0010051)1.74230900
150Renal duplication (HP:0000075)1.74183550
151Osteoarthritis (HP:0002758)1.73932108
152Bowing of the arm (HP:0006488)1.73550262
153Bowed forearm bones (HP:0003956)1.73550262
154Flexion contracture of toe (HP:0005830)1.73142795
155Joint contractures involving the joints of the feet (HP:0100492)1.73142795
156Abnormality of skull ossification (HP:0002703)1.71898249
157Ovoid vertebral bodies (HP:0003300)1.70706587
158Sparse lateral eyebrow (HP:0005338)1.70285316
159Flat cornea (HP:0007720)1.70221551
160* Natal tooth (HP:0000695)1.69088189
161Morphological abnormality of the middle ear (HP:0008609)1.68057736
162Broad long bones (HP:0005622)1.67636148
163Achilles tendon contracture (HP:0001771)1.67621062
164Hallux valgus (HP:0001822)1.67268557
165Upper limb amyotrophy (HP:0009129)1.67208409
166Distal upper limb amyotrophy (HP:0007149)1.67208409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.79053919
2INSRR5.61463483
3WNK35.35513223
4OXSR14.44735828
5STK38L3.28634395
6LATS13.10301361
7PDGFRA3.06525228
8TTN2.93176516
9DDR22.81863961
10AKT32.27983869
11TRPM72.27604671
12ICK2.10906435
13ERN11.93795396
14MET1.91024522
15STK391.82592831
16LATS21.81156110
17EPHB21.65070770
18TRIB31.60763297
19SIK11.46874912
20MST1R1.43699679
21BMX1.41211359
22NEK11.39609187
23WNK11.30472887
24LIMK11.29286999
25RPS6KA21.28220973
26PAK41.19837397
27EPHA31.19468172
28TESK11.19191029
29PTK21.19140225
30TGFBR21.14807635
31PDK31.10880109
32PDK41.10880109
33PINK11.10866958
34MAP3K61.07726316
35FER1.07017726
36BCKDK1.06087507
37EPHB11.05464170
38SGK4941.05345438
39SGK2231.05345438
40LMTK21.05065764
41PAK21.02446916
42STK30.99237461
43MAP3K30.97170393
44SMG10.94406179
45MAPKAPK30.93679846
46IRAK30.93273745
47ZAK0.91771839
48STK380.90041052
49MKNK20.89080885
50FGFR40.88189920
51MAPK70.87933224
52PRKD30.87228227
53PKN20.87061903
54ABL20.86536474
55PIK3CG0.85889759
56SGK20.83897426
57RIPK10.82796778
58ROCK10.79868885
59MELK0.78166802
60MYLK0.77658530
61DMPK0.77592740
62SGK30.75978348
63CDK120.75389400
64MKNK10.74497595
65PIM20.73915045
66FGFR10.73431809
67ERBB30.72933614
68PTK60.71764936
69FLT30.70298185
70KIT0.67225640
71LRRK20.66954069
72PRKD20.65703717
73RPS6KL10.64666574
74RPS6KC10.64666574
75DAPK30.60692978
76RPS6KA40.59751641
77GSK3A0.59213201
78PDGFRB0.58854732
79PDK20.58762431
80MAP3K70.57987993
81TNK20.56293990
82MARK20.56071565
83OBSCN0.54704929
84TIE10.53825505
85JAK10.53058704
86PTK2B0.52647752
87NEK90.51741323
88CDK80.50196575
89MAP3K100.48959330
90RPS6KA60.48836099
91BRD40.48798886
92CAMK1D0.48643692
93INSR0.47611658
94AKT20.46362032
95MTOR0.44227252
96PRKCI0.43179827
97ROCK20.43172473
98NEK20.42053241
99STK240.41352308
100CDK90.41300829
101PRKG20.41014930
102RET0.40433988
103SGK10.40377502
104PAK30.39782919
105CAMK1G0.39481908
106DYRK1B0.39216680
107PRKD10.38881393
108PAK60.38482188
109EEF2K0.37538494
110CLK10.36511602
111TAOK20.35588982
112CDK70.35250557
113MAP2K10.34085038
114NTRK10.32406297
115FGFR20.30997178
116CCNB10.29805119
117TGFBR10.28539330
118TTK0.28082858
119PDPK10.27336013
120MAP2K30.27220747
121FRK0.27156873
122MAPK10.27147539
123MAP3K20.26808049
124MAPKAPK20.26716697
125ZAP700.26579951
126EPHA20.24986615
127SRC0.23627054
128CHUK0.22364848
129EIF2AK20.21601852
130MOS0.21410543
131PRKAA20.20754759
132ERBB40.18085495
133TLK10.17586155
134MAPK110.17392107
135CSK0.16806039
136PRPF4B0.16573953
137ILK0.16516278
138CDC42BPA0.16171826
139ADRBK10.15226069
140AKT10.13677230
141IGF1R0.13045480
142PRKCH0.12391475
143PIM10.12124343

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.40218905
2Protein digestion and absorption_Homo sapiens_hsa049743.11438089
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.02474671
4Butanoate metabolism_Homo sapiens_hsa006502.77232331
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65587389
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.61876981
7Propanoate metabolism_Homo sapiens_hsa006402.61068811
8ECM-receptor interaction_Homo sapiens_hsa045122.56066734
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49660122
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25628035
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25482258
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20195228
13Basal cell carcinoma_Homo sapiens_hsa052172.14750825
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14120274
15Lysine degradation_Homo sapiens_hsa003102.10584222
16Hedgehog signaling pathway_Homo sapiens_hsa043402.01239662
17Vitamin digestion and absorption_Homo sapiens_hsa049771.90480678
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88675280
19Focal adhesion_Homo sapiens_hsa045101.78803828
20Tryptophan metabolism_Homo sapiens_hsa003801.73346644
21Pyruvate metabolism_Homo sapiens_hsa006201.71390082
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.69411444
23Fatty acid degradation_Homo sapiens_hsa000711.67654124
24Peroxisome_Homo sapiens_hsa041461.56558509
25Arginine and proline metabolism_Homo sapiens_hsa003301.42812353
26Hippo signaling pathway_Homo sapiens_hsa043901.30768956
27Carbon metabolism_Homo sapiens_hsa012001.29621786
28Mineral absorption_Homo sapiens_hsa049781.28631037
29Adherens junction_Homo sapiens_hsa045201.28086882
30Fatty acid metabolism_Homo sapiens_hsa012121.26885353
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25828187
32Collecting duct acid secretion_Homo sapiens_hsa049661.24300880
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23500673
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23257747
35beta-Alanine metabolism_Homo sapiens_hsa004101.23130384
36Proteoglycans in cancer_Homo sapiens_hsa052051.22951275
37Glutathione metabolism_Homo sapiens_hsa004801.22644321
38Complement and coagulation cascades_Homo sapiens_hsa046101.21248953
39Small cell lung cancer_Homo sapiens_hsa052221.18245780
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16557892
41Prion diseases_Homo sapiens_hsa050201.14198316
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13808137
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13541365
44Bile secretion_Homo sapiens_hsa049761.12571997
45Other glycan degradation_Homo sapiens_hsa005111.11995652
46Starch and sucrose metabolism_Homo sapiens_hsa005001.10695662
47Melanoma_Homo sapiens_hsa052181.10432463
48One carbon pool by folate_Homo sapiens_hsa006701.05259829
49Renin-angiotensin system_Homo sapiens_hsa046141.04580223
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02501817
51Malaria_Homo sapiens_hsa051441.01907823
52PPAR signaling pathway_Homo sapiens_hsa033200.98840869
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98340606
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98070288
55MicroRNAs in cancer_Homo sapiens_hsa052060.97109869
56Pancreatic cancer_Homo sapiens_hsa052120.95463938
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94262831
58Bladder cancer_Homo sapiens_hsa052190.94090907
59Renal cell carcinoma_Homo sapiens_hsa052110.93050657
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.92354167
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91292077
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90462891
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90093002
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85535268
65Dilated cardiomyopathy_Homo sapiens_hsa054140.85302155
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.83445307
67Thyroid hormone synthesis_Homo sapiens_hsa049180.83365308
68Biosynthesis of amino acids_Homo sapiens_hsa012300.82949071
69Gap junction_Homo sapiens_hsa045400.82052015
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.81950983
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81726852
72Lysosome_Homo sapiens_hsa041420.81283367
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.78936335
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.78420715
75Amoebiasis_Homo sapiens_hsa051460.77159493
76TGF-beta signaling pathway_Homo sapiens_hsa043500.75482107
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75433342
78TNF signaling pathway_Homo sapiens_hsa046680.74637672
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74222104
80mTOR signaling pathway_Homo sapiens_hsa041500.74131128
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73794921
82Endometrial cancer_Homo sapiens_hsa052130.73562872
83N-Glycan biosynthesis_Homo sapiens_hsa005100.71607109
84Thyroid cancer_Homo sapiens_hsa052160.69947664
85Prostate cancer_Homo sapiens_hsa052150.68296149
86GnRH signaling pathway_Homo sapiens_hsa049120.67008786
87Endocytosis_Homo sapiens_hsa041440.65997338
88Sulfur metabolism_Homo sapiens_hsa009200.65223762
89Estrogen signaling pathway_Homo sapiens_hsa049150.64861669
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63002992
91Glioma_Homo sapiens_hsa052140.62435084
92Toxoplasmosis_Homo sapiens_hsa051450.60878059
93Pathways in cancer_Homo sapiens_hsa052000.60407378
94ErbB signaling pathway_Homo sapiens_hsa040120.59319103
95Platelet activation_Homo sapiens_hsa046110.59280042
96Tight junction_Homo sapiens_hsa045300.58628289
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58349712
98VEGF signaling pathway_Homo sapiens_hsa043700.57778356
99Non-small cell lung cancer_Homo sapiens_hsa052230.57499522
100Insulin signaling pathway_Homo sapiens_hsa049100.56911051
101Wnt signaling pathway_Homo sapiens_hsa043100.56743343
102Ras signaling pathway_Homo sapiens_hsa040140.56096173
103FoxO signaling pathway_Homo sapiens_hsa040680.55233740
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54853828
105Phenylalanine metabolism_Homo sapiens_hsa003600.54081398
106Notch signaling pathway_Homo sapiens_hsa043300.53414074
107Galactose metabolism_Homo sapiens_hsa000520.52898659
108Ovarian steroidogenesis_Homo sapiens_hsa049130.52704455
109MAPK signaling pathway_Homo sapiens_hsa040100.52677490
110Colorectal cancer_Homo sapiens_hsa052100.50921807
111Arachidonic acid metabolism_Homo sapiens_hsa005900.50919014
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50656819
113p53 signaling pathway_Homo sapiens_hsa041150.50215339
114Rap1 signaling pathway_Homo sapiens_hsa040150.47595444
115Shigellosis_Homo sapiens_hsa051310.47358064
116Fructose and mannose metabolism_Homo sapiens_hsa000510.46998358
117Hepatitis B_Homo sapiens_hsa051610.46706776
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46672810
119Pertussis_Homo sapiens_hsa051330.45229926
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45197263
121Vibrio cholerae infection_Homo sapiens_hsa051100.44453606
122Glucagon signaling pathway_Homo sapiens_hsa049220.43422810
123Salmonella infection_Homo sapiens_hsa051320.42427317
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41762268
125Sphingolipid metabolism_Homo sapiens_hsa006000.41150112
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40903158
127AMPK signaling pathway_Homo sapiens_hsa041520.38791701
128Prolactin signaling pathway_Homo sapiens_hsa049170.38109610
129Apoptosis_Homo sapiens_hsa042100.38049939
130Chronic myeloid leukemia_Homo sapiens_hsa052200.37655277
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.37189181
132Acute myeloid leukemia_Homo sapiens_hsa052210.36973551
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.36919463
134Melanogenesis_Homo sapiens_hsa049160.35620705
135Gastric acid secretion_Homo sapiens_hsa049710.34117132
136Axon guidance_Homo sapiens_hsa043600.33331452
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32939100
138Arginine biosynthesis_Homo sapiens_hsa002200.31618188
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31432766
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31119332
141Choline metabolism in cancer_Homo sapiens_hsa052310.31045315
142HIF-1 signaling pathway_Homo sapiens_hsa040660.30569600
143Viral myocarditis_Homo sapiens_hsa054160.30297478
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30272573
145Insulin resistance_Homo sapiens_hsa049310.29985602
146Tyrosine metabolism_Homo sapiens_hsa003500.28509048
147HTLV-I infection_Homo sapiens_hsa051660.27370377
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.26020161

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