ETV7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type I interferon signaling pathway (GO:0060337)6.06735231
2cellular response to type I interferon (GO:0071357)6.06735231
3response to type I interferon (GO:0034340)5.97530317
4regulation of T-helper 1 cell differentiation (GO:0045625)5.15698034
5regulation of chronic inflammatory response (GO:0002676)4.91006953
6negative regulation of viral genome replication (GO:0045071)4.79344210
7regulation of interferon-alpha production (GO:0032647)4.65341157
8negative regulation of interleukin-12 production (GO:0032695)4.50135208
9interferon-gamma-mediated signaling pathway (GO:0060333)4.39920805
10immunoglobulin mediated immune response (GO:0016064)4.33944635
11positive regulation of interferon-alpha production (GO:0032727)4.19844116
12positive regulation of type 2 immune response (GO:0002830)4.13754768
13response to interferon-beta (GO:0035456)4.12235152
14regulation of dendritic cell antigen processing and presentation (GO:0002604)4.06130399
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02791700
16response to interferon-alpha (GO:0035455)3.98512500
17macrophage activation involved in immune response (GO:0002281)3.93127407
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91826010
19regulation of T cell tolerance induction (GO:0002664)3.86690535
20response to peptidoglycan (GO:0032494)3.85176445
21positive regulation of gamma-delta T cell activation (GO:0046645)3.81832518
22regulation of vitamin D biosynthetic process (GO:0060556)3.81743189
23antigen processing and presentation of endogenous antigen (GO:0019883)3.80590885
24defense response to protozoan (GO:0042832)3.79520050
25lipopolysaccharide-mediated signaling pathway (GO:0031663)3.70558297
26myeloid dendritic cell differentiation (GO:0043011)3.69698621
27positive regulation of cellular amide metabolic process (GO:0034250)3.68136173
28T-helper 1 type immune response (GO:0042088)3.65886589
29regulation of interferon-beta biosynthetic process (GO:0045357)3.58073918
30regulation of cytokine secretion involved in immune response (GO:0002739)3.57671973
31negative regulation of cell killing (GO:0031342)3.56876695
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56876695
33cellular response to interferon-alpha (GO:0035457)3.53882459
34cellular response to interferon-gamma (GO:0071346)3.53682328
35response to protozoan (GO:0001562)3.53297859
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51243179
37B cell mediated immunity (GO:0019724)3.50430342
38detection of other organism (GO:0098543)3.47470968
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46451228
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.46451228
41modulation by symbiont of host immune response (GO:0052553)3.46451228
42positive regulation by symbiont of host defense response (GO:0052509)3.46451228
43modulation by symbiont of host defense response (GO:0052031)3.46451228
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46451228
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.45151284
46positive regulation of antigen processing and presentation (GO:0002579)3.44694634
47response to interferon-gamma (GO:0034341)3.40596518
48regulation of type I interferon-mediated signaling pathway (GO:0060338)3.39949457
49germinal center formation (GO:0002467)3.39604151
50regulation of antigen processing and presentation (GO:0002577)3.39446961
51positive regulation of interferon-beta production (GO:0032728)3.37595543
52JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.32358184
53detection of bacterium (GO:0016045)3.32145041
54regulation of type 2 immune response (GO:0002828)3.32090813
55NIK/NF-kappaB signaling (GO:0038061)3.31243793
56regulation of viral genome replication (GO:0045069)3.30367389
57regulation of tolerance induction (GO:0002643)3.29603549
58defense response to virus (GO:0051607)3.28908756
59positive regulation of defense response to virus by host (GO:0002230)3.28542742
60myeloid dendritic cell activation (GO:0001773)3.26571543
61regulation of vitamin metabolic process (GO:0030656)3.25553625
62negative regulation of cytokine production involved in immune response (GO:0002719)3.24202009
63detection of molecule of bacterial origin (GO:0032490)3.23611055
64regulation of interleukin-12 production (GO:0032655)3.22375233
65regulation of regulatory T cell differentiation (GO:0045589)3.21517104
66negative regulation of viral process (GO:0048525)3.19718684
67regulation of T-helper cell differentiation (GO:0045622)3.19631449
68regulation of RIG-I signaling pathway (GO:0039535)3.17414432
69positive regulation of interleukin-1 beta secretion (GO:0050718)3.12135840
70positive regulation of toll-like receptor signaling pathway (GO:0034123)3.11300883
71interferon-gamma secretion (GO:0072643)3.10482131
72detection of external biotic stimulus (GO:0098581)3.06925851
73regulation of interleukin-1 beta secretion (GO:0050706)3.06486461
74cellular response to interferon-beta (GO:0035458)3.05815192
75T cell migration (GO:0072678)3.05015626
76production of molecular mediator involved in inflammatory response (GO:0002532)3.01367009
77positive regulation of NF-kappaB import into nucleus (GO:0042346)3.00803459
78regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.00386163
79neutrophil activation involved in immune response (GO:0002283)2.99459433
80lymphocyte chemotaxis (GO:0048247)2.99042377
81positive regulation of interleukin-12 production (GO:0032735)2.97046670
82negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.95664722
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94646204
84regulation of mononuclear cell migration (GO:0071675)2.93288050
85positive regulation of tolerance induction (GO:0002645)2.92462240
86positive regulation of interleukin-1 secretion (GO:0050716)2.92303087
87regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92078288
88dendritic cell differentiation (GO:0097028)2.91710760
89granulocyte activation (GO:0036230)2.91187184
90positive regulation of cAMP-mediated signaling (GO:0043950)2.86946456
91regulation of T-helper 1 type immune response (GO:0002825)2.86856396
92positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86727157
93regulation of inflammatory response to antigenic stimulus (GO:0002861)2.86348244
94positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.86152650
95positive regulation of T-helper cell differentiation (GO:0045624)2.86104408
96branching involved in labyrinthine layer morphogenesis (GO:0060670)2.85680900
97eosinophil chemotaxis (GO:0048245)2.85414799
98JAK-STAT cascade (GO:0007259)2.84845826
99positive regulation of chemokine biosynthetic process (GO:0045080)2.84680998
100negative regulation of T cell mediated immunity (GO:0002710)2.80410726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.55680202
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.40231098
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.83192577
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.23694905
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.67916446
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.38223992
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.63193978
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.52171404
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.47728408
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.01461349
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.95389513
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.92809889
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91531716
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69415619
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66556504
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24056074
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23645859
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16597114
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14399055
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.05476112
21GATA1_22025678_ChIP-Seq_K562_Human1.97087138
22MYB_26560356_Chip-Seq_TH2_Human1.92807759
23RUNX_20019798_ChIP-Seq_JUKART_Human1.91080989
24SPI1_23547873_ChIP-Seq_NB4_Human1.79115222
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73908731
26VDR_24787735_ChIP-Seq_THP-1_Human1.62048330
27MYB_26560356_Chip-Seq_TH1_Human1.55387780
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54077268
29GATA3_26560356_Chip-Seq_TH2_Human1.51599501
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49792214
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48708938
32MAF_26560356_Chip-Seq_TH1_Human1.46971164
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46962361
34EGR1_19032775_ChIP-ChIP_M12_Human1.42970713
35SPI1_23127762_ChIP-Seq_K562_Human1.41882352
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40635318
37PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40507969
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39934415
39GATA3_27048872_Chip-Seq_THYMUS_Human1.36671122
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35782485
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34728240
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33593053
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32085992
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.28067834
45VDR_24763502_ChIP-Seq_THP-1_Human1.27184826
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26552784
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26014281
48PU_27001747_Chip-Seq_BMDM_Mouse1.18844174
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12459383
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12211135
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10875065
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.07969857
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06939764
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.05061989
55CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04229525
56SCL_19346495_ChIP-Seq_HPC-7_Human1.03547706
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03220486
58MAF_26560356_Chip-Seq_TH2_Human1.02462968
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01113558
60UTX_26944678_Chip-Seq_JUKART_Human1.00560900
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99426815
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97354046
63EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96092942
64VDR_21846776_ChIP-Seq_THP-1_Human0.95808713
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95619626
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90048996
67GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88441905
68SOX2_20726797_ChIP-Seq_SW620_Human0.88159818
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86217652
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86070918
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85997459
72GATA1_19941827_ChIP-Seq_MEL_Mouse0.82553884
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80732847
74STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80714991
75STAT1_20625510_ChIP-Seq_HELA_Human0.80079253
76ESR1_21235772_ChIP-Seq_MCF-7_Human0.75358426
77BCL6_27268052_Chip-Seq_Bcells_Human0.73916084
78* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72954318
79RXR_22158963_ChIP-Seq_LIVER_Mouse0.71559510
80ESR2_21235772_ChIP-Seq_MCF-7_Human0.71553479
81PPARA_22158963_ChIP-Seq_LIVER_Mouse0.70599219
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68904609
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68653175
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.68532652
85LXR_22158963_ChIP-Seq_LIVER_Mouse0.67652330
86TP63_17297297_ChIP-ChIP_HaCaT_Human0.67565723
87* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67331407
88SMRT_27268052_Chip-Seq_Bcells_Human0.64970907
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64290384
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.64052200
91TFEB_21752829_ChIP-Seq_HELA_Human0.62967374
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62908516
93BCOR_27268052_Chip-Seq_Bcells_Human0.59577385
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.58537768
95* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.58129829
96TCF7_22412390_ChIP-Seq_EML_Mouse0.56857785
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.56607759
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56495685
99P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56252011
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.55437881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.57999673
2MP0003303_peritoneal_inflammation4.57086034
3MP0001835_abnormal_antigen_presentation3.91514777
4MP0009785_altered_susceptibility_to3.90189893
5MP0006082_CNS_inflammation3.63537695
6MP0002148_abnormal_hypersensitivity_rea3.55915605
7MP0005671_abnormal_response_to3.33169528
8MP0003436_decreased_susceptibility_to3.30679678
9MP0002138_abnormal_hepatobiliary_system3.02761009
10MP0001790_abnormal_immune_system3.00250943
11MP0005387_immune_system_phenotype3.00250943
12MP0005000_abnormal_immune_tolerance2.94303408
13MP0005025_abnormal_response_to2.88281649
14MP0001800_abnormal_humoral_immune2.74392749
15MP0002723_abnormal_immune_serum2.56438571
16MP0002419_abnormal_innate_immunity2.47933696
17MP0002452_abnormal_antigen_presenting2.42606689
18MP0004510_myositis2.38583816
19MP0000685_abnormal_immune_system2.37865432
20MP0003300_gastrointestinal_ulcer2.31854142
21MP0010155_abnormal_intestine_physiology2.28536845
22MP0009764_decreased_sensitivity_to2.15021886
23MP0001819_abnormal_immune_cell2.11914002
24MP0002420_abnormal_adaptive_immunity2.09580212
25MP0004947_skin_inflammation2.06631951
26MP0001845_abnormal_inflammatory_respons2.02985396
27MP0001533_abnormal_skeleton_physiology2.00506475
28MP0009333_abnormal_splenocyte_physiolog1.91661076
29MP0008469_abnormal_protein_level1.82096929
30MP0003806_abnormal_nucleotide_metabolis1.79252324
31MP0002139_abnormal_hepatobiliary_system1.77953928
32MP0005451_abnormal_body_composition1.76342795
33MP0005058_abnormal_lysosome_morphology1.73311695
34MP0003075_altered_response_to1.68357275
35MP0002405_respiratory_system_inflammati1.63589343
36MP0000716_abnormal_immune_system1.59342316
37MP0005310_abnormal_salivary_gland1.55905398
38MP0001853_heart_inflammation1.45360183
39MP0002332_abnormal_exercise_endurance1.44732001
40MP0003195_calcinosis1.44149705
41MP0008004_abnormal_stomach_pH1.43603084
42MP0002398_abnormal_bone_marrow1.43275169
43MP0003763_abnormal_thymus_physiology1.40855695
44MP0003172_abnormal_lysosome_physiology1.39422754
45MP0002254_reproductive_system_inflammat1.37799635
46MP0006054_spinal_hemorrhage1.37428398
47MP0003183_abnormal_peptide_metabolism1.29071865
48MP0009278_abnormal_bone_marrow1.28716854
49MP0003448_altered_tumor_morphology1.28389985
50MP0000343_altered_response_to1.27565648
51MP0005166_decreased_susceptibility_to1.26891323
52MP0009840_abnormal_foam_cell1.26255539
53MP0003191_abnormal_cellular_cholesterol1.25319513
54MP0000858_altered_metastatic_potential1.19615357
55MP0002429_abnormal_blood_cell1.18270983
56MP0001873_stomach_inflammation1.16761487
57MP0003453_abnormal_keratinocyte_physiol1.11419923
58MP0001545_abnormal_hematopoietic_system1.10576020
59MP0005397_hematopoietic_system_phenotyp1.10576020
60MP0000689_abnormal_spleen_morphology1.10445163
61MP0005464_abnormal_platelet_physiology1.09895007
62MP0002722_abnormal_immune_system1.06869916
63MP0005164_abnormal_response_to1.06445367
64MP0008260_abnormal_autophagy1.06203050
65MP0009763_increased_sensitivity_to1.03925770
66MP0002998_abnormal_bone_remodeling1.03669725
67MP0002277_abnormal_respiratory_mucosa0.98722600
68MP0003866_abnormal_defecation0.97425283
69MP0004883_abnormal_blood_vessel0.91707393
70MP0001663_abnormal_digestive_system0.85167113
71MP0000604_amyloidosis0.83029377
72MP0009765_abnormal_xenobiotic_induced0.79858765
73MP0005390_skeleton_phenotype0.79839988
74MP0005167_abnormal_blood-brain_barrier0.73938465
75MP0002166_altered_tumor_susceptibility0.72624745
76MP0003656_abnormal_erythrocyte_physiolo0.71203353
77MP0001851_eye_inflammation0.69148614
78MP0002006_tumorigenesis0.68462058
79MP0003690_abnormal_glial_cell0.68437316
80MP0003091_abnormal_cell_migration0.68327925
81MP0001501_abnormal_sleep_pattern0.68069773
82MP0005319_abnormal_enzyme/_coenzyme0.67824264
83MP0000490_abnormal_crypts_of0.67592430
84MP0002933_joint_inflammation0.66549947
85MP0005165_increased_susceptibility_to0.66358978
86MP0000465_gastrointestinal_hemorrhage0.66144128
87MP0000920_abnormal_myelination0.65744146
88MP0001542_abnormal_bone_strength0.65404173
89MP0008874_decreased_physiological_sensi0.61930776
90MP0000703_abnormal_thymus_morphology0.61044579
91MP0000249_abnormal_blood_vessel0.60289993
92MP0002693_abnormal_pancreas_physiology0.59079344
93MP0003045_fibrosis0.59064288
94MP0005365_abnormal_bile_salt0.56914072
95MP0000609_abnormal_liver_physiology0.54173792
96MP0005266_abnormal_metabolism0.53987852
97MP0009643_abnormal_urine_homeostasis0.52032469
98MP0005376_homeostasis/metabolism_phenot0.51291778
99MP0005535_abnormal_body_temperature0.49932626
100MP0003795_abnormal_bone_structure0.49325018

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)6.55986724
2Optic neuritis (HP:0100653)6.55986724
3Orchitis (HP:0100796)6.38138668
4Myositis (HP:0100614)5.77724642
5Stomatitis (HP:0010280)5.34907005
6Keratoconjunctivitis sicca (HP:0001097)4.61270938
7Eczematoid dermatitis (HP:0000976)4.43182097
8Recurrent bacterial skin infections (HP:0005406)4.37312736
9Abnormality of macrophages (HP:0004311)4.35227480
10Keratoconjunctivitis (HP:0001096)4.27586543
11Elevated erythrocyte sedimentation rate (HP:0003565)4.11210226
12Abnormality of liposaccharide metabolism (HP:0010968)4.10824626
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.10824626
14Abnormality of glycolipid metabolism (HP:0010969)4.10824626
15Recurrent abscess formation (HP:0002722)4.08188055
16Vasculitis (HP:0002633)3.89319403
17Mediastinal lymphadenopathy (HP:0100721)3.83495369
18Increased IgM level (HP:0003496)3.82380985
19Pulmonary infiltrates (HP:0002113)3.82274531
20Systemic lupus erythematosus (HP:0002725)3.76494950
21Gangrene (HP:0100758)3.66420333
22Autoimmune hemolytic anemia (HP:0001890)3.63597957
23Hemoptysis (HP:0002105)3.52121013
24Gastrointestinal infarctions (HP:0005244)3.47155321
25Abnormality of T cell number (HP:0011839)3.39617284
26Encephalitis (HP:0002383)3.36355165
27T lymphocytopenia (HP:0005403)3.31836637
28Recurrent fungal infections (HP:0002841)3.31539920
29Meningitis (HP:0001287)3.16027645
30Hypergammaglobulinemia (HP:0010702)3.15008246
31Recurrent viral infections (HP:0004429)3.09058192
32Loss of speech (HP:0002371)3.01648649
33Recurrent skin infections (HP:0001581)3.00592574
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.98333510
35Arterial thrombosis (HP:0004420)2.98238874
36Vacuolated lymphocytes (HP:0001922)2.95517622
37Recurrent gram-negative bacterial infections (HP:0005420)2.94552289
38Autoimmune thrombocytopenia (HP:0001973)2.92516355
39Anorexia (HP:0002039)2.86501466
40Abnormality of the pleura (HP:0002103)2.79023849
41Pulmonary embolism (HP:0002204)2.78966429
42Joint swelling (HP:0001386)2.77984545
43Chronic obstructive pulmonary disease (HP:0006510)2.75491334
44Obstructive lung disease (HP:0006536)2.75491334
45Chronic mucocutaneous candidiasis (HP:0002728)2.72210217
46Recurrent cutaneous fungal infections (HP:0011370)2.72210217
47Recurrent bronchitis (HP:0002837)2.69588071
48Abnormality of B cell number (HP:0010975)2.68096206
49Polyneuropathy (HP:0001271)2.62527302
50Chronic otitis media (HP:0000389)2.59883924
51Chronic diarrhea (HP:0002028)2.56559245
52Urticaria (HP:0001025)2.55542759
53Keratitis (HP:0000491)2.54605205
54Disinhibition (HP:0000734)2.53775803
55Malnutrition (HP:0004395)2.52464561
56Abnormality of the pericardium (HP:0001697)2.48824132
57Segmental peripheral demyelination/remyelination (HP:0003481)2.46281886
58Increased IgE level (HP:0003212)2.42706531
59Increased cerebral lipofuscin (HP:0011813)2.42208816
60Hematochezia (HP:0002573)2.39752566
61Dysostosis multiplex (HP:0000943)2.39439909
62Abnormality of T cells (HP:0002843)2.39140014
63B lymphocytopenia (HP:0010976)2.38212810
64Leukocytosis (HP:0001974)2.37955443
65Parakeratosis (HP:0001036)2.37368235
66Interstitial pulmonary disease (HP:0006530)2.36247701
67Gingivitis (HP:0000230)2.31420904
68IgA deficiency (HP:0002720)2.29180026
69Eosinophilia (HP:0001880)2.27674325
70Glomerulopathy (HP:0100820)2.26693209
71Episodic fever (HP:0001954)2.25949090
72Inflammation of the large intestine (HP:0002037)2.23948264
73Chest pain (HP:0100749)2.22401642
74Abnormality of the endocardium (HP:0004306)2.21397719
75Progressive neurologic deterioration (HP:0002344)2.20232296
76Granulocytopenia (HP:0001913)2.20148932
77IgG deficiency (HP:0004315)2.16751501
78Glomerulonephritis (HP:0000099)2.15503752
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13912697
80Abnormality of polysaccharide metabolism (HP:0011012)2.13912697
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13912697
82Pustule (HP:0200039)2.11896807
83Vertigo (HP:0002321)2.11271432
84Acne (HP:0001061)2.10284972
85Gastrointestinal inflammation (HP:0004386)2.08017755
86Increased CSF protein (HP:0002922)2.04779563
87Arthralgia (HP:0002829)2.03130445
88Nasal polyposis (HP:0100582)2.02357832
89Gastrointestinal stroma tumor (HP:0100723)2.02336666
90Amyloidosis (HP:0011034)2.01017372
91Increased serum ferritin (HP:0003281)2.00497415
92Peritonitis (HP:0002586)1.98330795
93Recurrent pneumonia (HP:0006532)1.97124347
94Urinary glycosaminoglycan excretion (HP:0003541)1.94316300
95Mucopolysacchariduria (HP:0008155)1.94316300
96Stomach cancer (HP:0012126)1.94287326
97Basal ganglia calcification (HP:0002135)1.92494986
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.92048175
99Muscle fibrillation (HP:0010546)1.91212909
100Abnormality of the prostate (HP:0008775)1.90129995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.69772167
2BLK3.67702738
3TXK3.39461088
4RIPK43.05738423
5IRAK42.92862247
6IKBKE2.92180254
7BMPR1B2.87764572
8JAK32.86726250
9MAP4K12.85855771
10TBK12.84807954
11GRK72.83193833
12MAP3K142.79349760
13IRAK32.71806313
14JAK12.28601740
15MATK2.27855007
16RIPK12.27116166
17CSK1.93939293
18CDK81.88433417
19IRAK11.86949583
20IKBKB1.86118572
21ERN11.78749921
22ZAP701.77870915
23TAOK21.71946252
24TGFBR11.67811657
25BMPR21.65180660
26FGFR41.63163380
27FGR1.58138692
28TAOK11.45869272
29KIT1.44580134
30JAK21.44196592
31PIM21.42278069
32PRPF4B1.40792248
33SIK31.39601352
34MAP3K31.33827280
35EPHA31.32676017
36SYK1.30317544
37ADRBK21.29286264
38LYN1.28248483
39DDR21.23224627
40MAP2K61.21620919
41MAP3K111.18237317
42LCK1.16994697
43FGFR31.06656516
44CHUK1.06613092
45TGFBR21.06145138
46BTK1.03449074
47ACVR1B0.98240663
48MAP2K30.95365651
49CDC42BPA0.94157939
50NME20.93480636
51EPHB10.93051103
52TEC0.91694893
53MOS0.90109610
54ITK0.87704689
55STK240.85691862
56HCK0.82942457
57MAP3K10.81509896
58CLK10.81199030
59IRAK20.80258654
60STK100.79227000
61TNK20.76686015
62CSF1R0.72336819
63DYRK30.71071694
64CDK90.69615658
65MARK30.67025252
66MAP3K50.67005773
67FES0.62245522
68HIPK20.59567429
69PKN10.58683047
70PIM10.56521388
71PRKCQ0.55558222
72MAPKAPK20.49632020
73TAOK30.41608072
74FYN0.39912307
75MAP3K130.39541357
76PRKCD0.35430741
77GRK60.34116433
78EGFR0.31857657
79DAPK10.30941502
80RPS6KA40.30677035
81PDK10.29772220
82TESK20.29373587
83ABL10.27886306
84MAPK70.27855860
85YES10.26358388
86EIF2AK20.25868344
87MAPKAPK30.24753789
88DAPK20.23673314
89STK380.22531549
90DAPK30.22386393
91MAP4K20.20894482
92RPS6KA50.20070044
93IGF1R0.19225030
94INSR0.19082894
95GRK50.18946754
96TLK10.18760423
97MAPK110.17482760
98TYRO30.15771379
99BCR0.14969206
100CDK60.14130467

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.63015373
2Autoimmune thyroid disease_Homo sapiens_hsa053203.13606613
3Graft-versus-host disease_Homo sapiens_hsa053323.09026641
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.91554199
5Asthma_Homo sapiens_hsa053102.91289668
6Staphylococcus aureus infection_Homo sapiens_hsa051502.80909420
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.71359178
8Leishmaniasis_Homo sapiens_hsa051402.70511824
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.61490326
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58991460
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.51493911
12Type I diabetes mellitus_Homo sapiens_hsa049402.44695841
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38321009
14Osteoclast differentiation_Homo sapiens_hsa043802.37380963
15Rheumatoid arthritis_Homo sapiens_hsa053232.29366836
16African trypanosomiasis_Homo sapiens_hsa051432.22430554
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18573204
18Measles_Homo sapiens_hsa051622.10787108
19Influenza A_Homo sapiens_hsa051642.09498843
20Primary immunodeficiency_Homo sapiens_hsa053402.00557190
21TNF signaling pathway_Homo sapiens_hsa046681.97430743
22Tuberculosis_Homo sapiens_hsa051521.92091412
23Malaria_Homo sapiens_hsa051441.88203114
24Antigen processing and presentation_Homo sapiens_hsa046121.83855298
25Hematopoietic cell lineage_Homo sapiens_hsa046401.81300514
26Herpes simplex infection_Homo sapiens_hsa051681.79344204
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.74323581
28Pertussis_Homo sapiens_hsa051331.72682786
29Legionellosis_Homo sapiens_hsa051341.71280977
30Toxoplasmosis_Homo sapiens_hsa051451.70606885
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.63999298
32Viral myocarditis_Homo sapiens_hsa054161.58359069
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54037031
34Hepatitis C_Homo sapiens_hsa051601.52407769
35Lysosome_Homo sapiens_hsa041421.28208182
36Salmonella infection_Homo sapiens_hsa051321.25884823
37Chemokine signaling pathway_Homo sapiens_hsa040621.25653976
38Other glycan degradation_Homo sapiens_hsa005111.24189259
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18556313
40Hepatitis B_Homo sapiens_hsa051611.08261885
41B cell receptor signaling pathway_Homo sapiens_hsa046621.07234832
42T cell receptor signaling pathway_Homo sapiens_hsa046601.04960602
43Phagosome_Homo sapiens_hsa041451.02647532
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93168278
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.93146832
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87155746
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84902747
48Apoptosis_Homo sapiens_hsa042100.83530489
49Prolactin signaling pathway_Homo sapiens_hsa049170.80287925
50Shigellosis_Homo sapiens_hsa051310.79143158
51Epstein-Barr virus infection_Homo sapiens_hsa051690.77607703
52Sulfur metabolism_Homo sapiens_hsa009200.74270762
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73402973
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67911839
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67171684
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56636100
57Complement and coagulation cascades_Homo sapiens_hsa046100.55918142
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.55614147
59Prion diseases_Homo sapiens_hsa050200.53395049
60Acute myeloid leukemia_Homo sapiens_hsa052210.51293564
61Amoebiasis_Homo sapiens_hsa051460.50852102
62Systemic lupus erythematosus_Homo sapiens_hsa053220.48623533
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45606280
64Type II diabetes mellitus_Homo sapiens_hsa049300.44528486
65Collecting duct acid secretion_Homo sapiens_hsa049660.42535092
66Tryptophan metabolism_Homo sapiens_hsa003800.42080739
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.38858051
68HTLV-I infection_Homo sapiens_hsa051660.36650114
69Arachidonic acid metabolism_Homo sapiens_hsa005900.35228197
70Sphingolipid metabolism_Homo sapiens_hsa006000.33959137
71* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33846616
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33846155
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32901488
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.31586079
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31373385
76Viral carcinogenesis_Homo sapiens_hsa052030.30680096
77Renin-angiotensin system_Homo sapiens_hsa046140.29586478
78Vitamin digestion and absorption_Homo sapiens_hsa049770.27395233
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26463861
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23609157
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.23375361
82Endocytosis_Homo sapiens_hsa041440.23272790
83Galactose metabolism_Homo sapiens_hsa000520.23024395
84Bladder cancer_Homo sapiens_hsa052190.20458171
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19435377
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18882167
87Fructose and mannose metabolism_Homo sapiens_hsa000510.18550372
88PPAR signaling pathway_Homo sapiens_hsa033200.15526287
89Pancreatic cancer_Homo sapiens_hsa052120.14687699
90Ether lipid metabolism_Homo sapiens_hsa005650.14122827
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.13809105
92VEGF signaling pathway_Homo sapiens_hsa043700.12704860
93Linoleic acid metabolism_Homo sapiens_hsa005910.12549648
94Insulin resistance_Homo sapiens_hsa049310.12268181
95Mineral absorption_Homo sapiens_hsa049780.11236959
96Platelet activation_Homo sapiens_hsa046110.06242383
97Caffeine metabolism_Homo sapiens_hsa002320.06145220
98HIF-1 signaling pathway_Homo sapiens_hsa040660.05781498
99Folate biosynthesis_Homo sapiens_hsa007900.05695313
100Peroxisome_Homo sapiens_hsa041460.04065211

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