ETV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)6.61276078
2axon ensheathment in central nervous system (GO:0032291)6.33703575
3central nervous system myelination (GO:0022010)6.33703575
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76456514
5neuronal action potential propagation (GO:0019227)4.72524523
6auditory behavior (GO:0031223)4.29994247
7neurotransmitter-gated ion channel clustering (GO:0072578)4.20783338
8glycine transport (GO:0015816)4.16931498
9ionotropic glutamate receptor signaling pathway (GO:0035235)3.97160059
10cerebellar granule cell differentiation (GO:0021707)3.91104921
11synaptic vesicle exocytosis (GO:0016079)3.87258051
12glutamate receptor signaling pathway (GO:0007215)3.78607330
13negative regulation of neurotransmitter transport (GO:0051589)3.77763058
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.75770708
15neuron cell-cell adhesion (GO:0007158)3.75521862
16regulation of synaptic vesicle exocytosis (GO:2000300)3.74747642
17synaptic vesicle maturation (GO:0016188)3.74014938
18synaptic transmission, glutamatergic (GO:0035249)3.69257435
19C4-dicarboxylate transport (GO:0015740)3.68959582
20locomotory exploration behavior (GO:0035641)3.68692887
21presynaptic membrane organization (GO:0097090)3.60680299
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.54369843
23negative regulation of protein localization to cell surface (GO:2000009)3.53721921
24long-chain fatty acid biosynthetic process (GO:0042759)3.51891292
25cellular potassium ion homeostasis (GO:0030007)3.51001908
26L-amino acid import (GO:0043092)3.50418649
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.48856388
28glutamate secretion (GO:0014047)3.48070163
29neuron-neuron synaptic transmission (GO:0007270)3.47499198
30myelination (GO:0042552)3.45317969
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43644772
32ensheathment of neurons (GO:0007272)3.41775342
33axon ensheathment (GO:0008366)3.41775342
34establishment of mitochondrion localization (GO:0051654)3.37466936
35regulation of short-term neuronal synaptic plasticity (GO:0048172)3.35458293
36adult walking behavior (GO:0007628)3.34824898
37membrane assembly (GO:0071709)3.32876639
38* mechanosensory behavior (GO:0007638)3.30952033
39presynaptic membrane assembly (GO:0097105)3.29993348
40vocalization behavior (GO:0071625)3.29978717
41fatty acid elongation (GO:0030497)3.26731324
42regulation of synaptic vesicle transport (GO:1902803)3.26644058
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25723789
44astrocyte differentiation (GO:0048708)3.25327197
45dermatan sulfate biosynthetic process (GO:0030208)3.23702421
46innervation (GO:0060384)3.23087102
47neuron recognition (GO:0008038)3.22716600
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21476111
49response to methylmercury (GO:0051597)3.19259177
50cerebellar Purkinje cell differentiation (GO:0021702)3.18053948
51gamma-aminobutyric acid transport (GO:0015812)3.18019844
52response to auditory stimulus (GO:0010996)3.16276454
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15902963
54transmission of nerve impulse (GO:0019226)3.13164558
55neuromuscular process controlling posture (GO:0050884)3.11201464
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10680005
57axonal fasciculation (GO:0007413)3.09913424
58regulation of neuronal synaptic plasticity (GO:0048168)3.09881431
59protein localization to synapse (GO:0035418)3.07177821
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05440241
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04419693
62regulation of synapse structural plasticity (GO:0051823)3.04193069
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02323436
64long-term memory (GO:0007616)3.01288992
65negative regulation of neurotransmitter secretion (GO:0046929)3.01067003
66regulation of amyloid precursor protein catabolic process (GO:1902991)2.98512841
67amino acid import (GO:0043090)2.97785102
68regulation of glutamate receptor signaling pathway (GO:1900449)2.97375186
69synapse assembly (GO:0007416)2.97031040
70regulation of vesicle fusion (GO:0031338)2.96276052
71detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.95707133
72detection of temperature stimulus involved in sensory perception (GO:0050961)2.95707133
73cellular sodium ion homeostasis (GO:0006883)2.93879813
74regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93189197
75cell differentiation in hindbrain (GO:0021533)2.91899543
76regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90975518
77long-term synaptic potentiation (GO:0060291)2.90331505
78cell communication by electrical coupling (GO:0010644)2.88960584
79dendritic spine morphogenesis (GO:0060997)2.88803241
80potassium ion import (GO:0010107)2.88007683
81dermatan sulfate metabolic process (GO:0030205)2.87227996
82negative regulation of execution phase of apoptosis (GO:1900118)2.87189900
83neurotransmitter secretion (GO:0007269)2.86933632
84pyrimidine nucleobase catabolic process (GO:0006208)2.85520806
85neuronal ion channel clustering (GO:0045161)2.83979943
86potassium ion homeostasis (GO:0055075)2.83512227
87regulation of cardiac muscle cell contraction (GO:0086004)2.82773827
88acidic amino acid transport (GO:0015800)2.81770004
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.80841944
90exploration behavior (GO:0035640)2.80142459
91oligodendrocyte differentiation (GO:0048709)2.79854125
92synaptic vesicle endocytosis (GO:0048488)2.78525922
93positive regulation of synapse assembly (GO:0051965)2.76005529
94apical protein localization (GO:0045176)2.75945633
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74823836
96regulation of beta-amyloid formation (GO:1902003)2.74489982
97photoreceptor cell differentiation (GO:0046530)2.74011608
98eye photoreceptor cell differentiation (GO:0001754)2.74011608
99positive regulation of potassium ion transport (GO:0043268)2.73813325
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.73412257
101regulation of postsynaptic membrane potential (GO:0060078)2.73383559
102suckling behavior (GO:0001967)2.73151159
103dendrite morphogenesis (GO:0048813)2.72235921
104neuron remodeling (GO:0016322)2.71613998
105myelin maintenance (GO:0043217)2.71212795
106positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70720664
107neurotransmitter uptake (GO:0001504)2.70177300
108regulation of voltage-gated calcium channel activity (GO:1901385)2.70176282
109membrane depolarization during action potential (GO:0086010)2.69709708
110regulation of respiratory system process (GO:0044065)2.69619364
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.69124254
112neurotransmitter transport (GO:0006836)2.69122340
113regulation of synaptic plasticity (GO:0048167)2.67404075
114cerebellar Purkinje cell layer development (GO:0021680)2.67387752
115response to dietary excess (GO:0002021)2.66951452
116mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.65369852
117organelle transport along microtubule (GO:0072384)2.64289035
118central nervous system projection neuron axonogenesis (GO:0021952)2.63611294
119regulation of calcium ion-dependent exocytosis (GO:0017158)2.62848979
120sodium ion export (GO:0071436)2.62561504
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62483150
122membrane depolarization (GO:0051899)2.60997136
123cellular response to cholesterol (GO:0071397)2.59818960
124layer formation in cerebral cortex (GO:0021819)2.58465142
125cranial nerve development (GO:0021545)2.58370005
126chondroitin sulfate catabolic process (GO:0030207)2.57153422
127cerebral cortex radially oriented cell migration (GO:0021799)2.56265782
128long term synaptic depression (GO:0060292)2.55979179
129L-glutamate transport (GO:0015813)2.55765201
130positive regulation of potassium ion transmembrane transport (GO:1901381)2.55190460
131vesicle transport along microtubule (GO:0047496)2.55118684
132regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.54625935
133regulation of neurotransmitter secretion (GO:0046928)2.54511817
134synapse organization (GO:0050808)2.52369865
135retinal ganglion cell axon guidance (GO:0031290)2.52217602
136regulation of dendritic spine morphogenesis (GO:0061001)2.51095227
137positive regulation of membrane potential (GO:0045838)2.49256540
138positive regulation of synapse maturation (GO:0090129)2.48318263
139regulation of neurotransmitter uptake (GO:0051580)2.47622079
140regulation of neurotransmitter transport (GO:0051588)2.47091100
141nonmotile primary cilium assembly (GO:0035058)2.46558893
142regulation of dendritic spine development (GO:0060998)2.46305953
143regulation of respiratory gaseous exchange (GO:0043576)2.44433172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.39858594
2GBX2_23144817_ChIP-Seq_PC3_Human3.63604741
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96891081
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91132927
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71507976
6SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49927584
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.46889323
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42637129
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42637129
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41829681
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41166710
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.38082564
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38065149
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33978961
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.30854229
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30439146
17REST_21632747_ChIP-Seq_MESCs_Mouse2.12017683
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.09555935
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.07379190
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03293288
21DROSHA_22980978_ChIP-Seq_HELA_Human2.01479695
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01352737
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.99631797
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96038404
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91962425
26* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89277574
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89271211
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83578910
29AR_21572438_ChIP-Seq_LNCaP_Human1.83032208
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.78483378
31* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75282565
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.74858041
33* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73744840
34TAF15_26573619_Chip-Seq_HEK293_Human1.73115767
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67091853
36SMAD4_21799915_ChIP-Seq_A2780_Human1.66974071
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60768557
38* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58269424
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54032669
40* P300_19829295_ChIP-Seq_ESCs_Human1.52773129
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51285004
42* PIAS1_25552417_ChIP-Seq_VCAP_Human1.49410728
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46133675
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44523871
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.42654032
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42479005
47* STAT3_23295773_ChIP-Seq_U87_Human1.41143225
48EWS_26573619_Chip-Seq_HEK293_Human1.40819176
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40628286
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40277878
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.39363937
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38526602
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37933367
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37933367
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36836876
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36731820
57ZNF274_21170338_ChIP-Seq_K562_Hela1.34320217
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33544056
59IGF1R_20145208_ChIP-Seq_DFB_Human1.33471200
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33331348
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32694652
62FUS_26573619_Chip-Seq_HEK293_Human1.32004617
63SOX9_26525672_Chip-Seq_HEART_Mouse1.31943230
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30784651
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28465818
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28305002
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27935681
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27564532
69TP53_16413492_ChIP-PET_HCT116_Human1.26560156
70* VDR_22108803_ChIP-Seq_LS180_Human1.26351324
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24297350
72* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22376298
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21194113
74* TCF4_23295773_ChIP-Seq_U87_Human1.19503098
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18069990
76ER_23166858_ChIP-Seq_MCF-7_Human1.17558702
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16721988
78* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15398177
79* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13032408
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12805812
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.12765855
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11334209
83* AR_25329375_ChIP-Seq_VCAP_Human1.11302969
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10518844
85* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10033731
86AR_19668381_ChIP-Seq_PC3_Human1.10009754
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09681733
88RNF2_27304074_Chip-Seq_NSC_Mouse1.09574033
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09231407
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.07978606
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07283661
92BCAT_22108803_ChIP-Seq_LS180_Human1.05882790
93* RING1B_27294783_Chip-Seq_ESCs_Mouse1.05089910
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.04852129
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.04397402
96JUN_21703547_ChIP-Seq_K562_Human1.04361373
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04151675
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03915330
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03806274
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03685393
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03395679
102TCF4_22108803_ChIP-Seq_LS180_Human1.03141710
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02911317
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02211080
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.01886330
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01601379
107* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00223640
108* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00080045
109AHR_22903824_ChIP-Seq_MCF-7_Human0.99595686
110* PRDM14_20953172_ChIP-Seq_ESCs_Human0.99357088
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.99123699
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98583737
113RING1B_27294783_Chip-Seq_NPCs_Mouse0.97926772
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96456081
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96456081
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96287915
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95326600
118* EP300_21415370_ChIP-Seq_HL-1_Mouse0.95243082
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95067582
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93464370
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93314131
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.91533423
123* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91410290
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90255842
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.89919995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.17949275
2MP0003880_abnormal_central_pattern4.04749193
3MP0004270_analgesia3.97291335
4MP0003635_abnormal_synaptic_transmissio3.22142734
5MP0009046_muscle_twitch2.98726781
6* MP0002272_abnormal_nervous_system2.84857626
7MP0002064_seizures2.81255460
8MP0009745_abnormal_behavioral_response2.69717624
9MP0002734_abnormal_mechanical_nocicepti2.54545698
10MP0000920_abnormal_myelination2.50934702
11MP0001968_abnormal_touch/_nociception2.46958310
12MP0002063_abnormal_learning/memory/cond2.45604474
13MP0002572_abnormal_emotion/affect_behav2.37615604
14MP0001486_abnormal_startle_reflex2.33099760
15MP0005423_abnormal_somatic_nervous2.32708994
16MP0000013_abnormal_adipose_tissue2.24809832
17MP0003329_amyloid_beta_deposits2.20708530
18MP0008569_lethality_at_weaning2.18365995
19MP0002735_abnormal_chemical_nociception2.15151369
20MP0004145_abnormal_muscle_electrophysio2.14767537
21MP0002067_abnormal_sensory_capabilities2.05196022
22MP0000778_abnormal_nervous_system2.02963593
23MP0004142_abnormal_muscle_tone2.01393448
24MP0002736_abnormal_nociception_after1.97749262
25MP0002733_abnormal_thermal_nociception1.95703516
26MP0001440_abnormal_grooming_behavior1.92559424
27MP0001970_abnormal_pain_threshold1.92249815
28MP0004885_abnormal_endolymph1.91665210
29MP0005645_abnormal_hypothalamus_physiol1.88916859
30MP0001529_abnormal_vocalization1.85964615
31MP0004742_abnormal_vestibular_system1.77928349
32MP0005171_absent_coat_pigmentation1.75883303
33* MP0002184_abnormal_innervation1.72798618
34MP0002837_dystrophic_cardiac_calcinosis1.69641557
35MP0000955_abnormal_spinal_cord1.68978788
36MP0003123_paternal_imprinting1.68154398
37MP0002653_abnormal_ependyma_morphology1.62163417
38MP0004043_abnormal_pH_regulation1.58495112
39MP0003633_abnormal_nervous_system1.57379758
40MP0003183_abnormal_peptide_metabolism1.52030931
41MP0003122_maternal_imprinting1.51551995
42MP0002909_abnormal_adrenal_gland1.51011967
43MP0001501_abnormal_sleep_pattern1.50612066
44MP0004924_abnormal_behavior1.45996939
45MP0005386_behavior/neurological_phenoty1.45996939
46MP0002557_abnormal_social/conspecific_i1.45622814
47MP0003634_abnormal_glial_cell1.44263822
48MP0003631_nervous_system_phenotype1.42422904
49MP0003690_abnormal_glial_cell1.42350422
50MP0001485_abnormal_pinna_reflex1.39734939
51* MP0002066_abnormal_motor_capabilities/c1.39719241
52* MP0002882_abnormal_neuron_morphology1.38705446
53MP0006276_abnormal_autonomic_nervous1.35690054
54MP0002229_neurodegeneration1.33897487
55MP0001905_abnormal_dopamine_level1.33224053
56MP0005187_abnormal_penis_morphology1.32943686
57MP0003632_abnormal_nervous_system1.32760847
58MP0000003_abnormal_adipose_tissue1.32038277
59MP0003195_calcinosis1.31195689
60MP0006292_abnormal_olfactory_placode1.29106235
61MP0003121_genomic_imprinting1.26220311
62MP0004811_abnormal_neuron_physiology1.25071716
63MP0008877_abnormal_DNA_methylation1.24665757
64MP0005253_abnormal_eye_physiology1.23224731
65MP0001299_abnormal_eye_distance/1.16770939
66MP0004858_abnormal_nervous_system1.16355668
67MP0009780_abnormal_chondrocyte_physiolo1.15419831
68MP0001502_abnormal_circadian_rhythm1.15007824
69MP0003787_abnormal_imprinting1.14848883
70MP0003861_abnormal_nervous_system1.13374674
71MP0003119_abnormal_digestive_system1.12002283
72MP0002233_abnormal_nose_morphology1.10841648
73MP0003937_abnormal_limbs/digits/tail_de1.09866648
74MP0005394_taste/olfaction_phenotype1.07463720
75MP0005499_abnormal_olfactory_system1.07463720
76MP0006072_abnormal_retinal_apoptosis1.06772601
77MP0000579_abnormal_nail_morphology1.05931359
78MP0003941_abnormal_skin_development1.05867536
79MP0002152_abnormal_brain_morphology1.05863589
80MP0005551_abnormal_eye_electrophysiolog1.04479054
81MP0003879_abnormal_hair_cell1.03803866
82MP0004133_heterotaxia1.02426634
83MP0000647_abnormal_sebaceous_gland1.02120250
84MP0001963_abnormal_hearing_physiology0.98205033
85MP0008789_abnormal_olfactory_epithelium0.94963558
86MP0005248_abnormal_Harderian_gland0.92898021
87MP0005379_endocrine/exocrine_gland_phen0.92477923
88MP0001188_hyperpigmentation0.91265845
89MP0000604_amyloidosis0.90550781
90MP0001293_anophthalmia0.90047980
91MP0003950_abnormal_plasma_membrane0.88138220
92MP0000049_abnormal_middle_ear0.86943305
93MP0000534_abnormal_ureter_morphology0.86448252
94MP0003136_yellow_coat_color0.85170909
95MP0003755_abnormal_palate_morphology0.84497179
96* MP0002752_abnormal_somatic_nervous0.83346067
97MP0000566_synostosis0.82979494
98MP0002938_white_spotting0.82256422
99MP0000631_abnormal_neuroendocrine_gland0.81196638
100MP0005646_abnormal_pituitary_gland0.80378136
101MP0002069_abnormal_eating/drinking_beha0.80163719
102MP0005409_darkened_coat_color0.79844826
103MP0002249_abnormal_larynx_morphology0.78284368
104MP0003283_abnormal_digestive_organ0.77521318
105MP0003137_abnormal_impulse_conducting0.76348670
106MP0000747_muscle_weakness0.75854705
107MP0003385_abnormal_body_wall0.75444104
108MP0005410_abnormal_fertilization0.75168877
109MP0010386_abnormal_urinary_bladder0.74754926
110MP0001984_abnormal_olfaction0.74700089
111MP0004085_abnormal_heartbeat0.74523934
112MP0001986_abnormal_taste_sensitivity0.74412081
113MP0004215_abnormal_myocardial_fiber0.73725446
114MP0003890_abnormal_embryonic-extraembry0.73273695
115MP0005167_abnormal_blood-brain_barrier0.72195061
116MP0002751_abnormal_autonomic_nervous0.71963661
117MP0005623_abnormal_meninges_morphology0.70862892
118MP0002638_abnormal_pupillary_reflex0.67261959
119MP0004134_abnormal_chest_morphology0.66278940
120MP0004036_abnormal_muscle_relaxation0.65275105
121MP0001177_atelectasis0.65143599
122MP0001943_abnormal_respiration0.63839616
123MP0002822_catalepsy0.63698355
124MP0004233_abnormal_muscle_weight0.62196638
125MP0000026_abnormal_inner_ear0.59281224
126MP0001765_abnormal_ion_homeostasis0.59238003
127MP0000751_myopathy0.58916381
128MP0004484_altered_response_of0.58694752

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.06938453
2Neurofibrillary tangles (HP:0002185)4.55710711
3Action tremor (HP:0002345)4.47440259
4Myokymia (HP:0002411)4.35550336
5Progressive cerebellar ataxia (HP:0002073)4.28175178
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.06035909
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.06035909
8Scanning speech (HP:0002168)3.92784652
9Focal seizures (HP:0007359)3.88491952
10Cerebral inclusion bodies (HP:0100314)3.77848400
11Supranuclear gaze palsy (HP:0000605)3.69453227
12Abnormality of the corticospinal tract (HP:0002492)3.69395142
13Visual hallucinations (HP:0002367)3.66952050
14Dysmetria (HP:0001310)3.47478264
15Hemiparesis (HP:0001269)3.41738164
16Epileptic encephalopathy (HP:0200134)3.39550433
17Insidious onset (HP:0003587)3.29848706
18Termporal pattern (HP:0011008)3.29848706
19Atonic seizures (HP:0010819)3.20131959
20Pheochromocytoma (HP:0002666)3.18855209
21Intention tremor (HP:0002080)3.15702442
22Ankle clonus (HP:0011448)3.12084936
23Gaze-evoked nystagmus (HP:0000640)3.11150072
24Dysdiadochokinesis (HP:0002075)3.08054318
25Retinal dysplasia (HP:0007973)3.04503381
26Peripheral hypomyelination (HP:0007182)3.01149355
27Spastic gait (HP:0002064)2.98687954
28Broad-based gait (HP:0002136)2.93097808
29Truncal ataxia (HP:0002078)2.91702351
30Agitation (HP:0000713)2.90645185
31Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.88751874
32Hepatoblastoma (HP:0002884)2.81585476
33Dialeptic seizures (HP:0011146)2.74532219
34Neuroendocrine neoplasm (HP:0100634)2.74033041
35Absence seizures (HP:0002121)2.67698824
36Abnormality of the diencephalon (HP:0010662)2.65105536
37Postural tremor (HP:0002174)2.64506074
38Anxiety (HP:0000739)2.57211154
39Onion bulb formation (HP:0003383)2.55295568
40Hyperventilation (HP:0002883)2.52828099
41Depression (HP:0000716)2.52077746
42Gait imbalance (HP:0002141)2.49625476
43Febrile seizures (HP:0002373)2.48596004
44Diplopia (HP:0000651)2.48279863
45Abnormality of binocular vision (HP:0011514)2.48279863
46Blue irides (HP:0000635)2.44662495
47Genetic anticipation (HP:0003743)2.42474723
48Generalized tonic-clonic seizures (HP:0002069)2.39839071
49Increased circulating renin level (HP:0000848)2.39689350
50Megalencephaly (HP:0001355)2.37879539
51Abnormality of the labia minora (HP:0012880)2.34536829
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.32742077
53Anteriorly placed anus (HP:0001545)2.31940595
54Epileptiform EEG discharges (HP:0011182)2.30065889
55Intestinal atresia (HP:0011100)2.28546130
56Segmental peripheral demyelination/remyelination (HP:0003481)2.25810945
57Impaired smooth pursuit (HP:0007772)2.25806645
58Abnormality of calcium-phosphate metabolism (HP:0100530)2.25229689
59Cerebral hypomyelination (HP:0006808)2.24063517
60EEG with generalized epileptiform discharges (HP:0011198)2.23127412
61Drooling (HP:0002307)2.19744958
62Excessive salivation (HP:0003781)2.19744958
63Alacrima (HP:0000522)2.18840685
64Thickened helices (HP:0000391)2.18162297
65Clumsiness (HP:0002312)2.17947778
66Retinal atrophy (HP:0001105)2.16441724
67Urinary urgency (HP:0000012)2.13197477
68Clonus (HP:0002169)2.13076302
69Oligodactyly (hands) (HP:0001180)2.12755871
70Hypsarrhythmia (HP:0002521)2.11236879
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11228776
72Gait ataxia (HP:0002066)2.10402135
73Lower limb muscle weakness (HP:0007340)2.10099638
74Type II lissencephaly (HP:0007260)2.09901128
75Status epilepticus (HP:0002133)2.09708000
76Congenital primary aphakia (HP:0007707)2.08908433
77Split foot (HP:0001839)2.08287536
78Morphological abnormality of the pyramidal tract (HP:0002062)2.07655287
79Colon cancer (HP:0003003)2.06125324
80Psychosis (HP:0000709)2.06063399
81Poor eye contact (HP:0000817)2.05988734
82Specific learning disability (HP:0001328)2.01149321
83Limb dystonia (HP:0002451)2.00709997
84Medial flaring of the eyebrow (HP:0010747)1.99945161
85Absent speech (HP:0001344)1.99128123
86Vaginal atresia (HP:0000148)1.99006756
87Abnormal auditory evoked potentials (HP:0006958)1.98805225
88Urinary bladder sphincter dysfunction (HP:0002839)1.96895367
89Restlessness (HP:0000711)1.95410130
90Dysautonomia (HP:0002459)1.94725842
91Impaired vibration sensation in the lower limbs (HP:0002166)1.93868498
92Septo-optic dysplasia (HP:0100842)1.93812635
93Abnormal eating behavior (HP:0100738)1.93420905
94Neuronal loss in central nervous system (HP:0002529)1.93404285
95True hermaphroditism (HP:0010459)1.92417625
96Cortical dysplasia (HP:0002539)1.91762131
97Abnormality of ocular smooth pursuit (HP:0000617)1.90876505
98Cutaneous finger syndactyly (HP:0010554)1.90273832
99Renal hypoplasia (HP:0000089)1.88964126
100Poor speech (HP:0002465)1.88522959
101White forelock (HP:0002211)1.86778053
102Nephrogenic diabetes insipidus (HP:0009806)1.86404293
103Menstrual irregularities (HP:0000858)1.86092227
104Hammertoe (HP:0001765)1.84878429
105Large for gestational age (HP:0001520)1.84418445
106Hemiplegia (HP:0002301)1.83862923
107Aplasia involving bones of the extremities (HP:0009825)1.83079741
108Aplasia involving bones of the upper limbs (HP:0009823)1.83079741
109Aplasia of the phalanges of the hand (HP:0009802)1.83079741
110Paraplegia (HP:0010550)1.82798073
111Gastrointestinal atresia (HP:0002589)1.82677206
112Anomalous pulmonary venous return (HP:0010772)1.82513480
113Polyphagia (HP:0002591)1.81853602
114Neoplasm of the oral cavity (HP:0100649)1.81094152
115Broad foot (HP:0001769)1.80164088
116Oligodactyly (HP:0012165)1.79480309
117Fibular hypoplasia (HP:0003038)1.78279650
118Cutaneous syndactyly (HP:0012725)1.77847664
119Metabolic alkalosis (HP:0200114)1.77076680
120Limb ataxia (HP:0002070)1.77010998
121Choreoathetosis (HP:0001266)1.76732327
122Sleep apnea (HP:0010535)1.76021718
123Glioma (HP:0009733)1.75504848
124Ulnar claw (HP:0001178)1.74934817
125Decreased lacrimation (HP:0000633)1.74891737
126Generalized myoclonic seizures (HP:0002123)1.74872628
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.74183686
128Abnormality of saccadic eye movements (HP:0000570)1.73226514
129Rib fusion (HP:0000902)1.73193753
130Anophthalmia (HP:0000528)1.72845297
131Genital tract atresia (HP:0001827)1.70933104
132Postural instability (HP:0002172)1.70769030
133Pancreatic islet-cell hyperplasia (HP:0004510)1.69586921
134Impaired social interactions (HP:0000735)1.69571154
135Abnormal social behavior (HP:0012433)1.69571154
136Hyperinsulinemic hypoglycemia (HP:0000825)1.69529397
137Optic nerve hypoplasia (HP:0000609)1.68728343
138Volvulus (HP:0002580)1.68673574
139Medulloblastoma (HP:0002885)1.68585316
140Hypoglycemic seizures (HP:0002173)1.66482119
141Astrocytoma (HP:0009592)1.66369528
142Abnormality of the astrocytes (HP:0100707)1.66369528
143Preaxial foot polydactyly (HP:0001841)1.65889865
144Postaxial hand polydactyly (HP:0001162)1.61446767
145Aqueductal stenosis (HP:0002410)1.57595733
146Pancreatic fibrosis (HP:0100732)1.57211285
147Neoplasm of the adrenal cortex (HP:0100641)1.56787469
148Short tibia (HP:0005736)1.56654451
149Spastic tetraplegia (HP:0002510)1.55262715
150Abnormality of the pulmonary veins (HP:0011718)1.54510750
151Poor coordination (HP:0002370)1.54213528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.63376041
2NTRK33.10882160
3STK393.04353110
4MAPK152.84066539
5OXSR12.57712908
6PNCK2.46312802
7WNK42.42725627
8CASK2.40282342
9MAP3K92.18437607
10WNK12.17595294
11UHMK12.13503939
12NTRK12.10475529
13MAP3K42.04677443
14MAPKAPK52.00167336
15CDK191.97757864
16STK38L1.91891449
17EPHA41.91241067
18MKNK21.77209167
19PAK61.67863004
20CAMKK21.67057539
21KSR21.64774702
22MINK11.63579120
23MAP2K71.62956501
24FRK1.62054136
25BCR1.58362288
26EPHB11.55045822
27CAMK2B1.54631619
28MARK11.52206015
29SGK4941.49754998
30SGK2231.49754998
31RIPK41.48326412
32DAPK21.44366164
33PRKD31.39270948
34PLK21.30983998
35ERBB41.30956931
36NTRK21.29668142
37PKN11.27040799
38TSSK61.26564836
39CAMK2D1.24217927
40CDK51.20968729
41CAMK2A1.18077871
42SGK21.16469820
43MKNK11.14548106
44MAP3K21.14413185
45MAP2K41.11288791
46ARAF1.06291229
47NEK61.00857455
48PAK31.00829186
49ROCK20.98634008
50CAMK2G0.95674656
51PLK30.95047394
52BMPR20.94656323
53LMTK20.91687597
54PIK3CG0.91448043
55GRK70.91103366
56GRK50.90470246
57PRKCG0.90004337
58CDK140.88179280
59KSR10.87222988
60MAP3K130.86699553
61DYRK1A0.86390122
62TNIK0.85796964
63MAPK130.85061430
64CDK30.82668323
65PRKCE0.81748654
66FGFR20.81715634
67EPHA30.81559224
68PRPF4B0.80956274
69WEE10.79858005
70ROCK10.79702203
71FER0.79359685
72CDK180.78467931
73CSNK1G20.78312289
74CDK150.77714537
75LIMK10.76755813
76MET0.75634307
77PTK2B0.75008764
78MARK20.71212107
79CSNK1A1L0.71195769
80PHKG10.70367187
81PHKG20.70367187
82CAMKK10.69206092
83CAMK1G0.68862996
84BMPR1B0.68527778
85INSRR0.68404415
86CDK11A0.68281852
87PRKCH0.67565639
88CSNK1G30.66702495
89PDGFRA0.65625861
90MAP4K20.65395306
91ERBB30.64751542
92TRIM280.64003982
93FGR0.63851822
94MAP3K120.63560235
95MAP3K10.63148912
96BRSK10.62086944
97HIPK20.61901630
98TYRO30.60198408
99SGK10.59834838
100CAMK10.58213466
101SGK30.57318031
102PINK10.56380424
103PDPK10.55463030
104ERBB20.54755410
105RET0.53779404
106PRKD10.53108861
107ADRBK20.52836897
108YES10.52164982
109CSNK1D0.52091570
110STK380.51428326
111LATS20.50560701
112FGFR10.50157255
113PBK0.49567765
114PRKG10.49255290
115MAPK100.49204418
116PTK20.48456394
117CSNK1A10.46764006
118PRKD20.45708038
119* PRKDC0.45128974
120CSNK1G10.44798267
121STK110.44128457
122CDC70.42631543
123CSNK1E0.42360418
124FYN0.42185024
125EPHB20.41718020
126SRPK10.41622898
127PRKACB0.40457688
128DMPK0.40369347
129PLK10.40274943
130TTK0.40076391
131TAF10.39985716
132CDC42BPA0.38157224
133PDK10.37703839
134DYRK20.36859426

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.24210867
2Glutamatergic synapse_Homo sapiens_hsa047242.63021265
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59901731
4GABAergic synapse_Homo sapiens_hsa047272.57336439
5Circadian entrainment_Homo sapiens_hsa047132.47584548
6Synaptic vesicle cycle_Homo sapiens_hsa047212.41027663
7Long-term potentiation_Homo sapiens_hsa047202.37970454
8Long-term depression_Homo sapiens_hsa047302.28798752
9Morphine addiction_Homo sapiens_hsa050322.24045256
10Insulin secretion_Homo sapiens_hsa049112.20706169
11Amphetamine addiction_Homo sapiens_hsa050312.14779741
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99819849
13Salivary secretion_Homo sapiens_hsa049701.97107406
14Taste transduction_Homo sapiens_hsa047421.96163920
15Dopaminergic synapse_Homo sapiens_hsa047281.91450110
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87307634
17Serotonergic synapse_Homo sapiens_hsa047261.85957552
18Vitamin B6 metabolism_Homo sapiens_hsa007501.79865159
19Gastric acid secretion_Homo sapiens_hsa049711.75436551
20Renin secretion_Homo sapiens_hsa049241.62489668
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56905441
22Collecting duct acid secretion_Homo sapiens_hsa049661.55520467
23Cocaine addiction_Homo sapiens_hsa050301.55313499
24Cholinergic synapse_Homo sapiens_hsa047251.49880126
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45781679
26Nitrogen metabolism_Homo sapiens_hsa009101.43098629
27Olfactory transduction_Homo sapiens_hsa047401.41821330
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36693782
29Vibrio cholerae infection_Homo sapiens_hsa051101.34178289
30Oxytocin signaling pathway_Homo sapiens_hsa049211.32372631
31Calcium signaling pathway_Homo sapiens_hsa040201.31418146
32Propanoate metabolism_Homo sapiens_hsa006401.29960498
33Fatty acid elongation_Homo sapiens_hsa000621.28824897
34Gap junction_Homo sapiens_hsa045401.27917615
35Ether lipid metabolism_Homo sapiens_hsa005651.27497561
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26275335
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20649925
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20209315
39cAMP signaling pathway_Homo sapiens_hsa040241.20030003
40Pancreatic secretion_Homo sapiens_hsa049721.19995895
41Axon guidance_Homo sapiens_hsa043601.18477200
42Butanoate metabolism_Homo sapiens_hsa006501.16769205
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.15350091
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15025772
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14924207
46Fatty acid metabolism_Homo sapiens_hsa012121.13544206
47Dorso-ventral axis formation_Homo sapiens_hsa043201.13152350
48Basal cell carcinoma_Homo sapiens_hsa052171.11637729
49GnRH signaling pathway_Homo sapiens_hsa049121.10762803
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.09890458
51Type II diabetes mellitus_Homo sapiens_hsa049301.09203026
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06654499
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06479364
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04941109
55Estrogen signaling pathway_Homo sapiens_hsa049151.03818892
56Hippo signaling pathway_Homo sapiens_hsa043901.03021705
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02994833
58Cardiac muscle contraction_Homo sapiens_hsa042601.02159257
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01775716
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97947483
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94566020
62Bile secretion_Homo sapiens_hsa049760.94556199
63beta-Alanine metabolism_Homo sapiens_hsa004100.93918393
64Oxidative phosphorylation_Homo sapiens_hsa001900.93141604
65Alzheimers disease_Homo sapiens_hsa050100.92396765
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91611699
67Melanogenesis_Homo sapiens_hsa049160.91511320
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90575787
69Thyroid hormone synthesis_Homo sapiens_hsa049180.89457253
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87996332
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84453094
72ErbB signaling pathway_Homo sapiens_hsa040120.82994055
73Steroid biosynthesis_Homo sapiens_hsa001000.82308271
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.80713448
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74744426
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74734783
77Fatty acid biosynthesis_Homo sapiens_hsa000610.72339260
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.70673902
79Renal cell carcinoma_Homo sapiens_hsa052110.70498728
80Sulfur metabolism_Homo sapiens_hsa009200.68427727
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67010686
82Sphingolipid metabolism_Homo sapiens_hsa006000.66891486
83Choline metabolism in cancer_Homo sapiens_hsa052310.65761211
84Pyruvate metabolism_Homo sapiens_hsa006200.64855999
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64200861
86Prion diseases_Homo sapiens_hsa050200.63700654
87Dilated cardiomyopathy_Homo sapiens_hsa054140.63522951
88Glioma_Homo sapiens_hsa052140.62918829
89Ras signaling pathway_Homo sapiens_hsa040140.61288730
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60131540
91Protein export_Homo sapiens_hsa030600.59781235
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58032253
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56882690
94Inositol phosphate metabolism_Homo sapiens_hsa005620.56429217
95Basal transcription factors_Homo sapiens_hsa030220.56395372
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56275906
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55157084
98Oocyte meiosis_Homo sapiens_hsa041140.54988039
99Endocytosis_Homo sapiens_hsa041440.53922494
100Parkinsons disease_Homo sapiens_hsa050120.53101173
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52862513
102MAPK signaling pathway_Homo sapiens_hsa040100.51969437
103Arginine and proline metabolism_Homo sapiens_hsa003300.51485925
104Phototransduction_Homo sapiens_hsa047440.51258395
105Circadian rhythm_Homo sapiens_hsa047100.51225441
106Hedgehog signaling pathway_Homo sapiens_hsa043400.49832162
107Histidine metabolism_Homo sapiens_hsa003400.49060866
108Notch signaling pathway_Homo sapiens_hsa043300.48750971
109Endometrial cancer_Homo sapiens_hsa052130.48685727
110Fatty acid degradation_Homo sapiens_hsa000710.48208364
111Linoleic acid metabolism_Homo sapiens_hsa005910.47997665
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47968199
113Tight junction_Homo sapiens_hsa045300.46014558
114Ovarian steroidogenesis_Homo sapiens_hsa049130.45880520
115Wnt signaling pathway_Homo sapiens_hsa043100.45841216
116Alcoholism_Homo sapiens_hsa050340.43942417
117Adherens junction_Homo sapiens_hsa045200.43525742
118Mineral absorption_Homo sapiens_hsa049780.43410587
119Folate biosynthesis_Homo sapiens_hsa007900.42892196
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42659013
121Rap1 signaling pathway_Homo sapiens_hsa040150.40495486
122MicroRNAs in cancer_Homo sapiens_hsa052060.39654162
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.39602652
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39304046
125TGF-beta signaling pathway_Homo sapiens_hsa043500.39282670
126Melanoma_Homo sapiens_hsa052180.37502136
127Lysine degradation_Homo sapiens_hsa003100.36773498
128Lysosome_Homo sapiens_hsa041420.36571125
129Glucagon signaling pathway_Homo sapiens_hsa049220.34486587
130Type I diabetes mellitus_Homo sapiens_hsa049400.34102210

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