ETF1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic chromosome segregation (GO:0045132)5.82240765
2regulation of memory T cell differentiation (GO:0043380)5.14259505
3rRNA catabolic process (GO:0016075)5.11055420
4C-terminal protein lipidation (GO:0006501)4.90967943
5preassembly of GPI anchor in ER membrane (GO:0016254)4.80127690
6C-terminal protein amino acid modification (GO:0018410)4.64811770
7cell wall macromolecule catabolic process (GO:0016998)4.61092401
8protein K11-linked deubiquitination (GO:0035871)4.51848094
9fatty acid elongation (GO:0030497)4.22873699
10adenosine metabolic process (GO:0046085)4.21939036
11peptidyl-threonine dephosphorylation (GO:0035970)4.20257386
12positive regulation of T cell cytokine production (GO:0002726)4.13205781
13positive regulation of prostaglandin secretion (GO:0032308)4.03953971
14cell wall macromolecule metabolic process (GO:0044036)4.03144934
15regulation of transmission of nerve impulse (GO:0051969)3.85695558
16protein deneddylation (GO:0000338)3.84340246
17ncRNA catabolic process (GO:0034661)3.82473435
18snRNA processing (GO:0016180)3.78369039
19cullin deneddylation (GO:0010388)3.76327961
20peptidyl-histidine modification (GO:0018202)3.69542712
21rRNA methylation (GO:0031167)3.69182567
22reciprocal meiotic recombination (GO:0007131)3.60406817
23reciprocal DNA recombination (GO:0035825)3.60406817
24regulation of meiosis I (GO:0060631)3.58875468
25mitochondrial RNA metabolic process (GO:0000959)3.58469009
26tryptophan catabolic process (GO:0006569)3.57106284
27indole-containing compound catabolic process (GO:0042436)3.57106284
28indolalkylamine catabolic process (GO:0046218)3.57106284
29negative regulation of DNA recombination (GO:0045910)3.56209714
30regulation of axon regeneration (GO:0048679)3.53727209
31regulation of neuron projection regeneration (GO:0070570)3.53727209
32histone mRNA metabolic process (GO:0008334)3.51975149
33acrosome assembly (GO:0001675)3.30831209
34mitochondrion degradation (GO:0000422)3.30270237
35iron-sulfur cluster assembly (GO:0016226)3.30119421
36metallo-sulfur cluster assembly (GO:0031163)3.30119421
37histone H2A acetylation (GO:0043968)3.28455974
38mismatch repair (GO:0006298)3.27893844
39rRNA modification (GO:0000154)3.26419521
40tryptophan metabolic process (GO:0006568)3.21314137
41regulation of prostaglandin secretion (GO:0032306)3.21040344
42kynurenine metabolic process (GO:0070189)3.16987650
43positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.14588551
44positive regulation of oligodendrocyte differentiation (GO:0048714)3.14131319
45response to pheromone (GO:0019236)3.10126699
46cornea development in camera-type eye (GO:0061303)3.09057866
47snRNA metabolic process (GO:0016073)3.08851951
48regulation of heat generation (GO:0031650)3.07930764
49lysine catabolic process (GO:0006554)3.07681275
50lysine metabolic process (GO:0006553)3.07681275
51intraciliary transport (GO:0042073)3.06999198
52signal peptide processing (GO:0006465)2.98695304
53resolution of meiotic recombination intermediates (GO:0000712)2.98302668
54somite development (GO:0061053)2.95361561
55GPI anchor metabolic process (GO:0006505)2.94858983
56L-fucose catabolic process (GO:0042355)2.93751330
57fucose catabolic process (GO:0019317)2.93751330
58L-fucose metabolic process (GO:0042354)2.93751330
59RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91715324
60mRNA cleavage (GO:0006379)2.84606790
61indolalkylamine metabolic process (GO:0006586)2.83842585
62somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82729520
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.82729520
64male meiosis (GO:0007140)2.82215831
65negative regulation of DNA-dependent DNA replication (GO:2000104)2.81830133
66folic acid metabolic process (GO:0046655)2.81751610
67termination of RNA polymerase I transcription (GO:0006363)2.77124981
68negative regulation of meiosis (GO:0045835)2.76132034
69detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.75846130
70DNA double-strand break processing (GO:0000729)2.75663421
71DNA ligation (GO:0006266)2.75034346
72negative regulation of defense response to virus (GO:0050687)2.74394561
73sleep (GO:0030431)2.73865667
74positive regulation of histone H3-K4 methylation (GO:0051571)2.73454574
75granulocyte differentiation (GO:0030851)2.71806778
76microtubule depolymerization (GO:0007019)2.71640693
77receptor recycling (GO:0001881)2.70616941
78somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67464973
79isotype switching (GO:0045190)2.67464973
80somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67464973
81monoubiquitinated protein deubiquitination (GO:0035520)2.67028282
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63922612
83regulation of mitotic spindle checkpoint (GO:1903504)2.63922612
84cilium morphogenesis (GO:0060271)2.63387333
85protein neddylation (GO:0045116)2.63261812
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63017726
87synapsis (GO:0007129)2.61304250
88auditory receptor cell stereocilium organization (GO:0060088)2.59280844
89GPI anchor biosynthetic process (GO:0006506)2.57105578
90positive regulation of heat generation (GO:0031652)2.56831873
91nephron tubule formation (GO:0072079)2.56812130
92aspartate family amino acid catabolic process (GO:0009068)2.53938477
93auditory behavior (GO:0031223)2.51468580
94spliceosomal snRNP assembly (GO:0000387)2.50580920
95meiosis I (GO:0007127)2.48429235
96phosphatidylinositol acyl-chain remodeling (GO:0036149)2.48008199
97negative regulation of B cell apoptotic process (GO:0002903)2.47390343
98coenzyme catabolic process (GO:0009109)2.47192918
99maturation of 5.8S rRNA (GO:0000460)2.46518422
100exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45406296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.10729270
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.68176367
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40168890
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.18979707
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.03241132
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.02232737
7ZNF274_21170338_ChIP-Seq_K562_Hela2.95702559
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65520239
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60439094
10EWS_26573619_Chip-Seq_HEK293_Human2.55536748
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34044374
12TAF15_26573619_Chip-Seq_HEK293_Human2.29832262
13ELK1_19687146_ChIP-ChIP_HELA_Human2.27621588
14VDR_23849224_ChIP-Seq_CD4+_Human2.27377282
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18725228
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.16478199
17FUS_26573619_Chip-Seq_HEK293_Human2.14488242
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.06841111
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.02616137
20PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94477785
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87298750
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77420701
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77007212
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75409979
25FOXP3_21729870_ChIP-Seq_TREG_Human1.73895279
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.73555121
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71771129
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68347875
29VDR_22108803_ChIP-Seq_LS180_Human1.64632987
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61335540
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57795516
32CIITA_25753668_ChIP-Seq_RAJI_Human1.52089559
33MYC_18940864_ChIP-ChIP_HL60_Human1.51797679
34P300_19829295_ChIP-Seq_ESCs_Human1.51251043
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.50617570
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.50422349
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48042036
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43541526
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41152792
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.40377633
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.38874008
42CBP_20019798_ChIP-Seq_JUKART_Human1.38845113
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38845113
44TP53_22573176_ChIP-Seq_HFKS_Human1.38718293
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37640925
46IRF1_19129219_ChIP-ChIP_H3396_Human1.36845753
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35731541
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34632056
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33103033
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32485151
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30990500
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30990500
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.30549462
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30101797
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25086314
56ER_23166858_ChIP-Seq_MCF-7_Human1.25049560
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24652198
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23845770
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23731703
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22540467
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21701014
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21275436
63GABP_19822575_ChIP-Seq_HepG2_Human1.19739265
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17168852
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.17158222
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16595404
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16352856
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15540481
69SOX2_19829295_ChIP-Seq_ESCs_Human1.15496268
70NANOG_19829295_ChIP-Seq_ESCs_Human1.15496268
71RBPJ_21746931_ChIP-Seq_IB4_Human1.14827423
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14759437
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.14759437
74DCP1A_22483619_ChIP-Seq_HELA_Human1.14667185
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14243465
76TCF4_23295773_ChIP-Seq_U87_Human1.13889319
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13784548
78GBX2_23144817_ChIP-Seq_PC3_Human1.13520324
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12756443
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12631681
81HTT_18923047_ChIP-ChIP_STHdh_Human1.12515289
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10490031
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10234396
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10094048
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05549304
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.05184872
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.04126324
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01046912
89GATA3_26560356_Chip-Seq_TH2_Human0.99802199
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99564380
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.98796585
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97189602
93LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96812815
94PHF8_20622853_ChIP-Seq_HELA_Human0.94074834
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93833983
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92804580
97MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92427158
98AR_20517297_ChIP-Seq_VCAP_Human0.92216550
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.91861478
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91129645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.16423880
2MP0005075_abnormal_melanosome_morpholog3.13038118
3MP0004782_abnormal_surfactant_physiolog3.05333945
4MP0000372_irregular_coat_pigmentation3.00508155
5MP0002736_abnormal_nociception_after2.80482641
6MP0004147_increased_porphyrin_level2.79319423
7MP0002254_reproductive_system_inflammat2.67932583
8MP0008058_abnormal_DNA_repair2.57261373
9MP0004381_abnormal_hair_follicle2.40328244
10MP0003806_abnormal_nucleotide_metabolis2.22329780
11MP0003786_premature_aging2.20270327
12MP0001986_abnormal_taste_sensitivity2.19220589
13MP0002102_abnormal_ear_morphology2.14054607
14MP0001968_abnormal_touch/_nociception2.01629468
15MP0001984_abnormal_olfaction1.92216067
16MP0004043_abnormal_pH_regulation1.84239201
17MP0005551_abnormal_eye_electrophysiolog1.82453604
18MP0006054_spinal_hemorrhage1.78485041
19MP0005310_abnormal_salivary_gland1.77975193
20MP0009697_abnormal_copulation1.77272788
21MP0005360_urolithiasis1.76999248
22MP0003011_delayed_dark_adaptation1.72206091
23MP0005408_hypopigmentation1.66191021
24MP0002876_abnormal_thyroid_physiology1.64267078
25MP0008875_abnormal_xenobiotic_pharmacok1.60645708
26MP0008995_early_reproductive_senescence1.58645942
27MP0010094_abnormal_chromosome_stability1.56877049
28MP0003718_maternal_effect1.56479030
29MP0005253_abnormal_eye_physiology1.51859819
30MP0003221_abnormal_cardiomyocyte_apopto1.47717568
31MP0001764_abnormal_homeostasis1.46302099
32MP0001502_abnormal_circadian_rhythm1.43915722
33MP0004484_altered_response_of1.40601901
34MP0002090_abnormal_vision1.38653391
35MP0000631_abnormal_neuroendocrine_gland1.36791569
36MP0002928_abnormal_bile_duct1.36675898
37MP0004957_abnormal_blastocyst_morpholog1.36443111
38MP0005671_abnormal_response_to1.33621036
39MP0001188_hyperpigmentation1.30305363
40MP0001727_abnormal_embryo_implantation1.27991494
41MP0005410_abnormal_fertilization1.26636947
42MP0000685_abnormal_immune_system1.23833136
43MP0003195_calcinosis1.21285173
44MP0008872_abnormal_physiological_respon1.21082899
45MP0004215_abnormal_myocardial_fiber1.19126345
46MP0009384_cardiac_valve_regurgitation1.18149974
47MP0001929_abnormal_gametogenesis1.14391666
48MP0003186_abnormal_redox_activity1.12847439
49MP0002638_abnormal_pupillary_reflex1.11099416
50MP0005332_abnormal_amino_acid1.09563819
51MP0008007_abnormal_cellular_replicative1.08449157
52MP0008961_abnormal_basal_metabolism1.07889771
53MP0003111_abnormal_nucleus_morphology1.07701416
54MP0001486_abnormal_startle_reflex1.05070798
55MP0003698_abnormal_male_reproductive1.03749976
56MP0004742_abnormal_vestibular_system1.03748777
57MP0004145_abnormal_muscle_electrophysio1.01458893
58MP0006035_abnormal_mitochondrial_morpho1.01252462
59MP0005646_abnormal_pituitary_gland1.00754935
60MP0002277_abnormal_respiratory_mucosa0.99448406
61MP0006072_abnormal_retinal_apoptosis0.98553655
62MP0005085_abnormal_gallbladder_physiolo0.98064516
63MP0000647_abnormal_sebaceous_gland0.93000898
64MP0002405_respiratory_system_inflammati0.92368656
65MP0003693_abnormal_embryo_hatching0.92295075
66MP0002166_altered_tumor_susceptibility0.91469524
67MP0001324_abnormal_eye_pigmentation0.91231119
68MP0005084_abnormal_gallbladder_morpholo0.89474616
69MP0002006_tumorigenesis0.88025050
70MP0000569_abnormal_digit_pigmentation0.87948079
71MP0003136_yellow_coat_color0.87599503
72MP0002210_abnormal_sex_determination0.86328354
73MP0008877_abnormal_DNA_methylation0.84355097
74MP0004133_heterotaxia0.84035587
75MP0002163_abnormal_gland_morphology0.83386506
76MP0009764_decreased_sensitivity_to0.83213439
77MP0003880_abnormal_central_pattern0.81652846
78MP0008260_abnormal_autophagy0.81372903
79MP0005167_abnormal_blood-brain_barrier0.81364990
80MP0000015_abnormal_ear_pigmentation0.81096282
81MP0005266_abnormal_metabolism0.79577897
82MP0001119_abnormal_female_reproductive0.79329377
83MP0000653_abnormal_sex_gland0.79020761
84MP0006276_abnormal_autonomic_nervous0.77527689
85MP0008932_abnormal_embryonic_tissue0.77444777
86MP0008873_increased_physiological_sensi0.77247310
87MP0002751_abnormal_autonomic_nervous0.76412885
88MP0004085_abnormal_heartbeat0.75940874
89MP0006036_abnormal_mitochondrial_physio0.75757977
90MP0002938_white_spotting0.74349607
91MP0002229_neurodegeneration0.73488838
92MP0001835_abnormal_antigen_presentation0.73109568
93MP0003724_increased_susceptibility_to0.72912001
94MP0001501_abnormal_sleep_pattern0.71335454
95MP0009115_abnormal_fat_cell0.71051046
96MP0002272_abnormal_nervous_system0.70996249
97MP0001485_abnormal_pinna_reflex0.69328473
98MP0001346_abnormal_lacrimal_gland0.68687579
99MP0002095_abnormal_skin_pigmentation0.67483555
100MP0000427_abnormal_hair_cycle0.67163527

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.38972541
2Septo-optic dysplasia (HP:0100842)4.32817194
3Pancreatic fibrosis (HP:0100732)4.05710824
4Medial flaring of the eyebrow (HP:0010747)3.87901246
5True hermaphroditism (HP:0010459)3.87603224
6Congenital primary aphakia (HP:0007707)3.77437120
7Gait imbalance (HP:0002141)3.67765110
8Abnormality of alanine metabolism (HP:0010916)3.55356587
9Hyperalaninemia (HP:0003348)3.55356587
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.55356587
11Bile duct proliferation (HP:0001408)3.42525750
12Abnormal biliary tract physiology (HP:0012439)3.42525750
13Nephrogenic diabetes insipidus (HP:0009806)3.39152712
14Abnormality of midbrain morphology (HP:0002418)3.21663688
15Molar tooth sign on MRI (HP:0002419)3.21663688
16Nephronophthisis (HP:0000090)3.19769514
17Attenuation of retinal blood vessels (HP:0007843)3.14872777
18Chronic hepatic failure (HP:0100626)3.10623708
19Renal cortical cysts (HP:0000803)3.00152129
20Occipital encephalocele (HP:0002085)2.95910084
21Abnormality of the renal cortex (HP:0011035)2.93908100
22Poor coordination (HP:0002370)2.92730997
23Optic nerve hypoplasia (HP:0000609)2.92352283
24Vaginal atresia (HP:0000148)2.86642583
25Severe combined immunodeficiency (HP:0004430)2.86622130
26Genital tract atresia (HP:0001827)2.84373519
27Chronic bronchitis (HP:0004469)2.78053099
28Cerebellar dysplasia (HP:0007033)2.75953088
29Tubular atrophy (HP:0000092)2.60923695
30Type II lissencephaly (HP:0007260)2.60772304
31Biliary tract neoplasm (HP:0100574)2.59298648
32Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.58773496
33Postaxial foot polydactyly (HP:0001830)2.58715500
34Abnormality of B cell number (HP:0010975)2.55820737
35Abnormality of the renal medulla (HP:0100957)2.49905963
36Cystic liver disease (HP:0006706)2.45897640
37Combined immunodeficiency (HP:0005387)2.39039973
38Decreased circulating renin level (HP:0003351)2.37472692
39Atonic seizures (HP:0010819)2.36019902
40Alveolar cell carcinoma (HP:0006519)2.32944723
41Decreased central vision (HP:0007663)2.32099089
42Thyroiditis (HP:0100646)2.30268899
43Clumsiness (HP:0002312)2.28750346
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.28462110
45IgG deficiency (HP:0004315)2.28196581
463-Methylglutaconic aciduria (HP:0003535)2.27909427
47Absent septum pellucidum (HP:0001331)2.26598638
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25615213
49Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25615213
50B lymphocytopenia (HP:0010976)2.25095395
51Broad-based gait (HP:0002136)2.23893814
52Abnormality of the septum pellucidum (HP:0007375)2.23018712
53Abnormality of the sella turcica (HP:0002679)2.22461558
54Sclerocornea (HP:0000647)2.21104364
55Bronchitis (HP:0012387)2.17143300
56Supernumerary spleens (HP:0009799)2.15842310
57Neoplasm of the tracheobronchial system (HP:0100552)2.14101879
58Abnormality of T cell number (HP:0011839)2.13827011
59Hypoplasia of the thymus (HP:0000778)2.13231986
60Broad foot (HP:0001769)2.12084218
61Rhinitis (HP:0012384)2.09612511
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08898171
63Abnormality of serum amino acid levels (HP:0003112)2.08860413
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06881590
65Ependymoma (HP:0002888)2.05348084
66Abnormal drinking behavior (HP:0030082)2.03690154
67Polydipsia (HP:0001959)2.03690154
68Gaze-evoked nystagmus (HP:0000640)2.02565588
69Anencephaly (HP:0002323)2.01365662
70Abnormality of eosinophils (HP:0001879)2.00639114
71Abnormal rod and cone electroretinograms (HP:0008323)1.98702095
72Specific learning disability (HP:0001328)1.96546759
73Hypoproteinemia (HP:0003075)1.96527035
74Postaxial hand polydactyly (HP:0001162)1.93154351
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92163049
76Progressive inability to walk (HP:0002505)1.91642961
77Aplasia/Hypoplasia of the tibia (HP:0005772)1.90950068
78Hypomagnesemia (HP:0002917)1.90697812
79Aplasia/Hypoplasia of the lens (HP:0008063)1.90120025
80Retinitis pigmentosa (HP:0000510)1.89554211
81Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89102943
82Abnormal delayed hypersensitivity skin test (HP:0002963)1.88483142
83Stomach cancer (HP:0012126)1.87117170
84Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85863038
85Primary adrenal insufficiency (HP:0008207)1.85358885
86Constricted visual fields (HP:0001133)1.84937548
87Increased serum lactate (HP:0002151)1.83663140
88Flat occiput (HP:0005469)1.80261879
89Abnormality of T cell physiology (HP:0011840)1.79918493
90Bony spicule pigmentary retinopathy (HP:0007737)1.77686296
91Congenital hepatic fibrosis (HP:0002612)1.77094040
92Neoplasm of the rectum (HP:0100743)1.75530609
93Recurrent bronchitis (HP:0002837)1.75267813
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73686887
95Furrowed tongue (HP:0000221)1.73337284
96Hyperventilation (HP:0002883)1.73228390
97Congenital stationary night blindness (HP:0007642)1.73018718
98Oculomotor apraxia (HP:0000657)1.72786829
99Astigmatism (HP:0000483)1.72698209
100Abnormality of the anterior horn cell (HP:0006802)1.69808732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.85485248
2MAP4K23.82319762
3CASK3.52453126
4DYRK33.29130833
5NUAK12.94233203
6MKNK22.87154369
7FRK2.66945708
8PRKD32.41561382
9MKNK12.38921239
10BLK2.38006296
11TAOK32.20974824
12BCR2.18909825
13ACVR1B2.14677390
14FES2.04901433
15MST41.87221953
16MAPKAPK31.81350104
17EIF2AK31.78790298
18SRPK11.76227461
19TLK11.61874359
20MAPK131.53851621
21MAP3K51.52039458
22BMPR1B1.48195675
23PBK1.47573356
24ADRBK21.42905793
25MAP2K71.39336964
26NEK21.39251221
27RPS6KA41.32516976
28NEK11.27934335
29PLK31.24976772
30WNK41.24521479
31MAP3K41.20391278
32WNK31.19392072
33BMPR21.11419727
34ERBB41.07834906
35TRIM281.07758716
36BUB11.02704545
37VRK11.00664320
38PINK10.96335761
39CSNK1G30.94256491
40LATS10.94036456
41ATR0.93060178
42TXK0.88061616
43STK160.87456449
44CCNB10.87172287
45PLK10.86011683
46TTK0.80125312
47CSNK1G20.78096084
48CSNK1G10.77467473
49WEE10.76426967
50TNIK0.74833496
51EPHA40.73758547
52OXSR10.72360968
53PLK40.72116449
54PLK20.69231985
55GRK10.69202481
56MARK30.66203744
57STK38L0.65566587
58CSNK1A1L0.65133685
59TSSK60.64245000
60CDK190.64148151
61ERBB30.62490185
62AKT30.61365325
63NLK0.59871618
64PRKCQ0.59805508
65INSRR0.58439657
66ERBB20.56695420
67MATK0.56373316
68PKN10.54163322
69SIK30.51846530
70IKBKB0.50985155
71CAMK1D0.49145861
72STK390.47629918
73RPS6KA50.45802034
74CAMK40.45090666
75FER0.44743978
76BMX0.43254688
77MAPKAPK50.42355017
78FLT30.41503176
79MARK10.40898843
80DYRK20.39851380
81PIK3CG0.39668204
82CSNK1A10.39462650
83AURKB0.39037215
84BRD40.37709580
85TNK20.37327181
86ATM0.36960017
87PIM10.36455653
88MAP3K90.34833311
89CAMK2A0.34681757
90PRKACB0.34031384
91CSNK2A10.33906143
92CHUK0.33206614
93NEK60.33164652
94PDK10.32138541
95CSNK1E0.31316618
96PRKCE0.31164102
97MAP3K60.30935217
98PAK30.29561415
99ABL20.29111668
100CAMK10.28952371

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.85799289
2Proteasome_Homo sapiens_hsa030503.42105293
3Non-homologous end-joining_Homo sapiens_hsa034503.02388489
4Regulation of autophagy_Homo sapiens_hsa041402.98674588
5Selenocompound metabolism_Homo sapiens_hsa004502.96308356
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73288086
7Basal transcription factors_Homo sapiens_hsa030222.44075784
8Systemic lupus erythematosus_Homo sapiens_hsa053222.29898681
9Propanoate metabolism_Homo sapiens_hsa006402.22229654
10One carbon pool by folate_Homo sapiens_hsa006702.20729732
11RNA polymerase_Homo sapiens_hsa030202.12288234
12Mismatch repair_Homo sapiens_hsa034302.07651646
13Primary immunodeficiency_Homo sapiens_hsa053401.92078652
14Sulfur metabolism_Homo sapiens_hsa009201.90303614
15Nitrogen metabolism_Homo sapiens_hsa009101.84104988
16Olfactory transduction_Homo sapiens_hsa047401.74895845
17Protein export_Homo sapiens_hsa030601.72851429
18Linoleic acid metabolism_Homo sapiens_hsa005911.69104095
19RNA degradation_Homo sapiens_hsa030181.65140104
20Fatty acid elongation_Homo sapiens_hsa000621.61927529
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61264124
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55112304
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.53605304
24Alcoholism_Homo sapiens_hsa050341.50842228
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.49481694
26Homologous recombination_Homo sapiens_hsa034401.45112564
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37345923
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35456320
29RNA transport_Homo sapiens_hsa030131.35173784
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34338704
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34091965
32Phototransduction_Homo sapiens_hsa047441.32082027
33Base excision repair_Homo sapiens_hsa034101.26825990
34Spliceosome_Homo sapiens_hsa030401.25994334
35Caffeine metabolism_Homo sapiens_hsa002321.25359673
36Nicotine addiction_Homo sapiens_hsa050331.25155916
37Ether lipid metabolism_Homo sapiens_hsa005651.18471656
38Graft-versus-host disease_Homo sapiens_hsa053321.18127351
39Fanconi anemia pathway_Homo sapiens_hsa034601.16874731
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10302223
41Fatty acid metabolism_Homo sapiens_hsa012121.09870235
42Tryptophan metabolism_Homo sapiens_hsa003801.08932422
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08704889
44Allograft rejection_Homo sapiens_hsa053301.07937230
45Autoimmune thyroid disease_Homo sapiens_hsa053201.06858924
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06361511
47Fat digestion and absorption_Homo sapiens_hsa049751.00683725
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99806027
49Steroid biosynthesis_Homo sapiens_hsa001000.99423810
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92842736
51Pyruvate metabolism_Homo sapiens_hsa006200.91804320
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.91774440
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90696370
54Fatty acid degradation_Homo sapiens_hsa000710.87596425
55Pyrimidine metabolism_Homo sapiens_hsa002400.87385966
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86619866
57mRNA surveillance pathway_Homo sapiens_hsa030150.86542686
58Herpes simplex infection_Homo sapiens_hsa051680.83392595
59Purine metabolism_Homo sapiens_hsa002300.82162197
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77757981
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77214662
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.76374643
63Circadian rhythm_Homo sapiens_hsa047100.76109633
64Sulfur relay system_Homo sapiens_hsa041220.74766311
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.74527216
66Nucleotide excision repair_Homo sapiens_hsa034200.73181153
67Viral carcinogenesis_Homo sapiens_hsa052030.71979526
68Fatty acid biosynthesis_Homo sapiens_hsa000610.71392581
69p53 signaling pathway_Homo sapiens_hsa041150.67422545
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65500713
71Oxidative phosphorylation_Homo sapiens_hsa001900.64261566
72Butanoate metabolism_Homo sapiens_hsa006500.61261132
73Peroxisome_Homo sapiens_hsa041460.58205791
74Morphine addiction_Homo sapiens_hsa050320.54530255
75Taste transduction_Homo sapiens_hsa047420.54297328
76Huntingtons disease_Homo sapiens_hsa050160.53446287
77Type I diabetes mellitus_Homo sapiens_hsa049400.52872315
78Lysine degradation_Homo sapiens_hsa003100.51261165
79Oocyte meiosis_Homo sapiens_hsa041140.50600083
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49432609
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49378424
82Cell cycle_Homo sapiens_hsa041100.47291164
83Arachidonic acid metabolism_Homo sapiens_hsa005900.45529943
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45335035
85DNA replication_Homo sapiens_hsa030300.43891102
86Parkinsons disease_Homo sapiens_hsa050120.43793710
87Metabolic pathways_Homo sapiens_hsa011000.43163364
88Antigen processing and presentation_Homo sapiens_hsa046120.42631144
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40412072
90Epstein-Barr virus infection_Homo sapiens_hsa051690.37921598
91Renin-angiotensin system_Homo sapiens_hsa046140.37507955
92Chemical carcinogenesis_Homo sapiens_hsa052040.36083345
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.32322971
94Measles_Homo sapiens_hsa051620.31883521
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30331627
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30044108
97Glutathione metabolism_Homo sapiens_hsa004800.29846442
98PPAR signaling pathway_Homo sapiens_hsa033200.29053497
99Retinol metabolism_Homo sapiens_hsa008300.28987745
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28767614

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