ETF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.28351214
2nuclear pore complex assembly (GO:0051292)5.17508541
3folic acid-containing compound biosynthetic process (GO:0009396)4.63265649
4protein localization to kinetochore (GO:0034501)4.57755450
5ribosome assembly (GO:0042255)4.41049149
6mitotic nuclear envelope disassembly (GO:0007077)4.36770680
7cellular protein complex localization (GO:0034629)4.27071648
8DNA unwinding involved in DNA replication (GO:0006268)4.25021040
9establishment of integrated proviral latency (GO:0075713)4.20753095
10mitotic metaphase plate congression (GO:0007080)4.18277482
11membrane disassembly (GO:0030397)4.14918504
12nuclear envelope disassembly (GO:0051081)4.14918504
13Golgi transport vesicle coating (GO:0048200)4.10019740
14COPI coating of Golgi vesicle (GO:0048205)4.10019740
15formation of translation preinitiation complex (GO:0001731)4.09273721
16protein complex localization (GO:0031503)4.07964162
17IMP biosynthetic process (GO:0006188)4.03442639
18nucleobase biosynthetic process (GO:0046112)3.97140123
19DNA replication-dependent nucleosome assembly (GO:0006335)3.96462320
20DNA replication-dependent nucleosome organization (GO:0034723)3.96462320
21pore complex assembly (GO:0046931)3.89203713
22regulation of gene silencing by RNA (GO:0060966)3.83228709
23regulation of posttranscriptional gene silencing (GO:0060147)3.83228709
24regulation of gene silencing by miRNA (GO:0060964)3.83228709
25protein localization to chromosome, centromeric region (GO:0071459)3.79683302
26regulation of spindle organization (GO:0090224)3.76722696
27purine nucleobase biosynthetic process (GO:0009113)3.73347826
28IMP metabolic process (GO:0046040)3.66938153
29DNA replication initiation (GO:0006270)3.66121669
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59466211
31heterochromatin organization (GO:0070828)3.56229892
32metaphase plate congression (GO:0051310)3.51515682
33mitotic chromosome condensation (GO:0007076)3.51360649
34positive regulation of chromosome segregation (GO:0051984)3.45144634
35pre-miRNA processing (GO:0031054)3.44958505
36regulation of translational fidelity (GO:0006450)3.41626171
37nucleobase-containing small molecule interconversion (GO:0015949)3.40716755
38regulation of mitotic spindle organization (GO:0060236)3.39447254
39ribosome biogenesis (GO:0042254)3.36835653
40mitotic sister chromatid cohesion (GO:0007064)3.36193313
41maturation of SSU-rRNA (GO:0030490)3.36164181
42DNA duplex unwinding (GO:0032508)3.36076125
43folic acid metabolic process (GO:0046655)3.35642471
44DNA geometric change (GO:0032392)3.35394328
45nuclear envelope organization (GO:0006998)3.32618100
46regulation of RNA export from nucleus (GO:0046831)3.30877467
47DNA replication checkpoint (GO:0000076)3.23173745
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20254843
49regulation of histone H3-K9 methylation (GO:0051570)3.18674440
50negative regulation of histone methylation (GO:0031061)3.17508644
51establishment of viral latency (GO:0019043)3.16636981
52histone H2A monoubiquitination (GO:0035518)3.15103767
53protein export from nucleus (GO:0006611)3.15016611
54regulation of nucleobase-containing compound transport (GO:0032239)3.14284073
55sister chromatid segregation (GO:0000819)3.13590878
56DNA strand elongation involved in DNA replication (GO:0006271)3.13121038
57mitotic sister chromatid segregation (GO:0000070)3.11861826
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.08278595
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08278595
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08278595
61chaperone-mediated protein complex assembly (GO:0051131)3.04057577
62establishment of chromosome localization (GO:0051303)3.02727632
63regulation of centrosome cycle (GO:0046605)3.00635726
64chromatin assembly (GO:0031497)2.99993806
65regulation of helicase activity (GO:0051095)2.97142779
66positive regulation of SMAD protein import into nucleus (GO:0060391)2.96694146
67regulation of sister chromatid cohesion (GO:0007063)2.95694971
68DNA strand elongation (GO:0022616)2.93167023
69regulation of chromosome segregation (GO:0051983)2.91147920
70telomere maintenance via semi-conservative replication (GO:0032201)2.91017838
71spliceosomal tri-snRNP complex assembly (GO:0000244)2.90524455
72chromatin remodeling at centromere (GO:0031055)2.88218177
73ribonucleoprotein complex biogenesis (GO:0022613)2.88135182
74ribosomal large subunit biogenesis (GO:0042273)2.86110025
75chromatin assembly or disassembly (GO:0006333)2.85962144
76protein localization to chromosome (GO:0034502)2.85829769
77negative regulation of DNA repair (GO:0045738)2.85573818
78negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83843766
79paraxial mesoderm development (GO:0048339)2.83811682
80monoubiquitinated protein deubiquitination (GO:0035520)2.83199622
81chromosome condensation (GO:0030261)2.82065073
82DNA topological change (GO:0006265)2.81638724
83spindle checkpoint (GO:0031577)2.81123500
84DNA replication-independent nucleosome assembly (GO:0006336)2.80831728
85DNA replication-independent nucleosome organization (GO:0034724)2.80831728
86tetrahydrofolate metabolic process (GO:0046653)2.77933126
87attachment of spindle microtubules to kinetochore (GO:0008608)2.77159660
88double-strand break repair via nonhomologous end joining (GO:0006303)2.74266397
89non-recombinational repair (GO:0000726)2.74266397
90CENP-A containing nucleosome assembly (GO:0034080)2.74173185
91embryonic process involved in female pregnancy (GO:0060136)2.73770263
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73457317
93NLS-bearing protein import into nucleus (GO:0006607)2.72583553
94translational initiation (GO:0006413)2.71738123
95negative regulation of translational initiation (GO:0045947)2.71553707
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70876831
97mRNA stabilization (GO:0048255)2.70575459
98RNA stabilization (GO:0043489)2.70575459
99mitotic spindle checkpoint (GO:0071174)2.70482484
100negative regulation of chromosome segregation (GO:0051985)2.69898041
101protein localization to endosome (GO:0036010)2.69833490
102dosage compensation (GO:0007549)2.68217114
103proline biosynthetic process (GO:0006561)2.68203525
104histone H2B ubiquitination (GO:0033523)2.67288321
105protein K6-linked ubiquitination (GO:0085020)2.66517947
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.65442894
107regulation of SMAD protein import into nucleus (GO:0060390)2.64721011
108spindle assembly checkpoint (GO:0071173)2.64347488
109DNA conformation change (GO:0071103)2.64228250
110negative regulation of mitotic sister chromatid separation (GO:2000816)2.63332134
111negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63332134
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.63332134
113negative regulation of sister chromatid segregation (GO:0033046)2.63332134
114regulation of centriole replication (GO:0046599)2.63048128
115histone-serine phosphorylation (GO:0035404)2.62624757
116mitotic spindle assembly checkpoint (GO:0007094)2.61967190
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61165759
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.61165759
119mRNA transport (GO:0051028)2.61057735
120tRNA aminoacylation for protein translation (GO:0006418)2.61004077
121regulation of translation in response to stress (GO:0043555)2.59133718
122histone exchange (GO:0043486)2.58029972
123regulation of translational elongation (GO:0006448)2.57875757
124pinocytosis (GO:0006907)2.55747892
125negative regulation of mRNA metabolic process (GO:1903312)2.54009231
126tRNA aminoacylation (GO:0043039)2.53210154
127amino acid activation (GO:0043038)2.53210154
128telomere maintenance via recombination (GO:0000722)2.50120860
129ribosomal small subunit biogenesis (GO:0042274)2.46985457
130DNA packaging (GO:0006323)2.46099402
131nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.45626559
132negative regulation of mRNA processing (GO:0050686)2.45158931
133mitotic recombination (GO:0006312)2.44319676
134COPII vesicle coating (GO:0048208)2.43716328
135mitotic nuclear envelope reassembly (GO:0007084)2.40927344
136nuclear envelope reassembly (GO:0031468)2.40927344
137regulation of histone H3-K27 methylation (GO:0061085)2.39188713
138protein localization to microtubule (GO:0035372)2.37890455
139mitochondrial DNA metabolic process (GO:0032042)2.37815249
140regulation of mammary gland epithelial cell proliferation (GO:0033599)2.35427275
141regulation of translational initiation (GO:0006446)2.35103768
142trophoblast giant cell differentiation (GO:0060707)2.32951330
1433-UTR-mediated mRNA stabilization (GO:0070935)2.31571884
144hemidesmosome assembly (GO:0031581)2.30477659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23530780
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.38686962
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.86021238
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30110238
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.23801729
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08140314
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87459536
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76877653
9AR_21909140_ChIP-Seq_LNCAP_Human2.50054716
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49414736
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28099348
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27053128
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19846059
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10859140
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.08943812
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06960203
17MYC_22102868_ChIP-Seq_BL_Human1.98503013
18E2F1_21310950_ChIP-Seq_MCF-7_Human1.97843331
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96218221
20XRN2_22483619_ChIP-Seq_HELA_Human1.91086959
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85280057
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83746957
23* ETS1_20019798_ChIP-Seq_JURKAT_Human1.83567022
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82425646
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82084627
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80664709
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.78034520
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76617919
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67220993
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66785640
31* GABP_17652178_ChIP-ChIP_JURKAT_Human1.64917608
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64913704
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64364737
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.63468394
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62474305
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60945441
37VDR_23849224_ChIP-Seq_CD4+_Human1.60630055
38ZNF263_19887448_ChIP-Seq_K562_Human1.56640224
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56227593
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.55332144
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52369238
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50917140
43DCP1A_22483619_ChIP-Seq_HELA_Human1.47211916
44KDM5A_27292631_Chip-Seq_BREAST_Human1.47042920
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45808695
46* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44491955
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39097384
48ELK1_19687146_ChIP-ChIP_HELA_Human1.37769688
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37411065
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37411065
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37411065
52TFEB_21752829_ChIP-Seq_HELA_Human1.36689941
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36183139
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36091171
55TTF2_22483619_ChIP-Seq_HELA_Human1.35842315
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35202280
57* GABP_19822575_ChIP-Seq_HepG2_Human1.34454747
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34243786
59FOXP3_21729870_ChIP-Seq_TREG_Human1.31103036
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26689062
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25002077
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23600747
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22910413
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22910413
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22883585
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22177309
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20554389
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18709058
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17326757
70* CLOCK_20551151_ChIP-Seq_293T_Human1.16865416
71ATF3_27146783_Chip-Seq_COLON_Human1.16604947
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16068318
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15255422
74* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12613345
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12392307
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10227872
77CIITA_25753668_ChIP-Seq_RAJI_Human1.10107604
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09155756
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07801784
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06538476
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.05911708
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05509065
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05356760
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04627156
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04451914
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04375789
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03594484
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02625699
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02398815
90CHD1_26751641_Chip-Seq_LNCaP_Human1.02335619
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02069482
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01875729
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01803689
94* SOX17_20123909_ChIP-Seq_XEN_Mouse1.01558550
95TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99794988
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98971886
97* NANOG_21062744_ChIP-ChIP_HESCs_Human0.98551269
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98549172
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98509163
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97942009
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97657669
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.97315407
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97112710
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97001573
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96908618
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96732891
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96554825
108BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96361072
109* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95713410
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95494684
111UBF1/2_26484160_Chip-Seq_HMECs_Human0.95126929
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95074160
113* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95026740
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94438302
115* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94009057
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93824909
117RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93589949
118* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93155828
119* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92456329
120VDR_21846776_ChIP-Seq_THP-1_Human0.92349887
121* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91279534
122RACK7_27058665_Chip-Seq_MCF-7_Human0.90575770
123* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88950635
124SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88845758
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86537997
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85590752
127THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84573781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.02327052
2MP0004957_abnormal_blastocyst_morpholog3.56351415
3MP0010352_gastrointestinal_tract_polyps3.51204760
4MP0003111_abnormal_nucleus_morphology3.36582529
5MP0003705_abnormal_hypodermis_morpholog3.21224555
6MP0010094_abnormal_chromosome_stability3.15799708
7MP0003077_abnormal_cell_cycle3.03647697
8MP0008057_abnormal_DNA_replication2.61491097
9MP0010307_abnormal_tumor_latency2.57226172
10MP0001730_embryonic_growth_arrest2.38633472
11MP0005076_abnormal_cell_differentiation2.38132218
12MP0000350_abnormal_cell_proliferation2.13179973
13MP0005451_abnormal_body_composition2.12664134
14MP0010234_abnormal_vibrissa_follicle2.12525001
15MP0003123_paternal_imprinting2.10278663
16MP0008007_abnormal_cellular_replicative1.99701561
17MP0008058_abnormal_DNA_repair1.88135182
18MP0004233_abnormal_muscle_weight1.87761359
19MP0005380_embryogenesis_phenotype1.87701404
20MP0001672_abnormal_embryogenesis/_devel1.87701404
21MP0003566_abnormal_cell_adhesion1.80667454
22MP0008932_abnormal_embryonic_tissue1.78930579
23MP0004197_abnormal_fetal_growth/weight/1.78131043
24MP0003984_embryonic_growth_retardation1.74790022
25MP0002088_abnormal_embryonic_growth/wei1.73629473
26MP0001697_abnormal_embryo_size1.73017802
27MP0002086_abnormal_extraembryonic_tissu1.71307392
28MP0002084_abnormal_developmental_patter1.65446231
29MP0002009_preneoplasia1.54304366
30MP0002080_prenatal_lethality1.53994249
31MP0002085_abnormal_embryonic_tissue1.53434591
32MP0009053_abnormal_anal_canal1.53123526
33MP0004272_abnormal_basement_membrane1.51485152
34MP0003806_abnormal_nucleotide_metabolis1.50345936
35MP0003567_abnormal_fetal_cardiomyocyte1.42561931
36MP0005023_abnormal_wound_healing1.41432785
37MP0004185_abnormal_adipocyte_glucose1.38875802
38MP0000537_abnormal_urethra_morphology1.38183853
39MP0002396_abnormal_hematopoietic_system1.34939733
40MP0001661_extended_life_span1.34479896
41MP0008438_abnormal_cutaneous_collagen1.33371194
42MP0002877_abnormal_melanocyte_morpholog1.32237187
43MP0003950_abnormal_plasma_membrane1.27023307
44MP0000733_abnormal_muscle_development1.24206939
45MP0000490_abnormal_crypts_of1.23468995
46MP0009697_abnormal_copulation1.22671471
47MP0000579_abnormal_nail_morphology1.19229624
48MP0004808_abnormal_hematopoietic_stem1.18706858
49MP0003890_abnormal_embryonic-extraembry1.18699059
50MP0002019_abnormal_tumor_incidence1.17524469
51MP0008260_abnormal_autophagy1.16250477
52MP0004782_abnormal_surfactant_physiolog1.15739699
53MP0005275_abnormal_skin_tensile1.12335744
54MP0003786_premature_aging1.09304748
55MP0000313_abnormal_cell_death1.07717029
56MP0001849_ear_inflammation1.06980941
57MP0002254_reproductive_system_inflammat1.04993326
58MP0010030_abnormal_orbit_morphology1.03343066
59MP0009672_abnormal_birth_weight1.02551749
60MP0003656_abnormal_erythrocyte_physiolo1.02159197
61MP0003221_abnormal_cardiomyocyte_apopto1.01036582
62MP0003453_abnormal_keratinocyte_physiol0.98397420
63MP0001293_anophthalmia0.98171312
64MP0000750_abnormal_muscle_regeneration0.98064013
65MP0001915_intracranial_hemorrhage0.97759872
66MP0003300_gastrointestinal_ulcer0.97524507
67MP0009333_abnormal_splenocyte_physiolog0.93710720
68MP0001727_abnormal_embryo_implantation0.93708870
69MP0003718_maternal_effect0.93136796
70MP0001881_abnormal_mammary_gland0.92845332
71MP0001853_heart_inflammation0.92380969
72MP0003448_altered_tumor_morphology0.91741913
73MP0000858_altered_metastatic_potential0.91585760
74MP0003191_abnormal_cellular_cholesterol0.91489969
75MP0003119_abnormal_digestive_system0.90545366
76MP0003941_abnormal_skin_development0.89934061
77MP0005409_darkened_coat_color0.89687239
78MP0001348_abnormal_lacrimal_gland0.89043823
79MP0005621_abnormal_cell_physiology0.88995498
80MP0009703_decreased_birth_body0.88051773
81MP0004264_abnormal_extraembryonic_tissu0.87763269
82MP0000428_abnormal_craniofacial_morphol0.87061582
83MP0006054_spinal_hemorrhage0.86400428
84MP0005058_abnormal_lysosome_morphology0.85963362
85MP0000627_abnormal_mammary_gland0.85478575
86MP0002111_abnormal_tail_morphology0.85064543
87MP0002166_altered_tumor_susceptibility0.84833424
88MP0005257_abnormal_intraocular_pressure0.84631600
89MP0002092_abnormal_eye_morphology0.82582873
90MP0003303_peritoneal_inflammation0.81036125
91MP0003937_abnormal_limbs/digits/tail_de0.80714404
92MP0000762_abnormal_tongue_morphology0.79962120
93MP0001545_abnormal_hematopoietic_system0.79864390
94MP0005397_hematopoietic_system_phenotyp0.79864390
95MP0005384_cellular_phenotype0.79488959
96MP0002098_abnormal_vibrissa_morphology0.79400912
97MP0000358_abnormal_cell_content/0.78666340
98MP0009278_abnormal_bone_marrow0.78549154
99MP0005375_adipose_tissue_phenotype0.78451844
100MP0005666_abnormal_adipose_tissue0.78402498
101MP0009931_abnormal_skin_appearance0.77784047
102MP0005501_abnormal_skin_physiology0.77598538
103MP0010771_integument_phenotype0.77488133
104MP0002697_abnormal_eye_size0.76271332
105MP0008877_abnormal_DNA_methylation0.75883781
106MP0002060_abnormal_skin_morphology0.75758763
107MP0000003_abnormal_adipose_tissue0.74299386
108MP0005623_abnormal_meninges_morphology0.74249955
109MP0002925_abnormal_cardiovascular_devel0.73953377
110MP0010630_abnormal_cardiac_muscle0.73888364
111MP0001216_abnormal_epidermal_layer0.73523810
112MP0003091_abnormal_cell_migration0.71554419
113MP0000477_abnormal_intestine_morphology0.70657175
114MP0000747_muscle_weakness0.70637865
115MP0000377_abnormal_hair_follicle0.70546462
116MP0000703_abnormal_thymus_morphology0.70514445
117MP0004084_abnormal_cardiac_muscle0.70049969
118MP0009840_abnormal_foam_cell0.69683202
119MP0010678_abnormal_skin_adnexa0.67717179
120MP0004947_skin_inflammation0.66796300
121MP0002796_impaired_skin_barrier0.65872634
122MP0003121_genomic_imprinting0.64484169
123MP0000432_abnormal_head_morphology0.64370638
124MP0002210_abnormal_sex_determination0.64298807
125MP0001145_abnormal_male_reproductive0.62887468
126MP0001243_abnormal_dermal_layer0.61400907
127MP0002006_tumorigenesis0.61157113
128MP0005367_renal/urinary_system_phenotyp0.61074404
129MP0000516_abnormal_urinary_system0.61074404

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.66289080
2Birth length less than 3rd percentile (HP:0003561)3.22235899
3Selective tooth agenesis (HP:0001592)3.13921875
4Colon cancer (HP:0003003)3.11399211
5Progressive external ophthalmoplegia (HP:0000590)3.04778284
6Biliary tract neoplasm (HP:0100574)3.01205122
7Progressive muscle weakness (HP:0003323)2.93889860
8Breast hypoplasia (HP:0003187)2.90288281
9Ankyloglossia (HP:0010296)2.81673851
10Rhabdomyosarcoma (HP:0002859)2.71060354
11Deviation of the thumb (HP:0009603)2.70279592
12Agnosia (HP:0010524)2.67210997
13Proximal placement of thumb (HP:0009623)2.61970153
14Astrocytoma (HP:0009592)2.61757333
15Abnormality of the astrocytes (HP:0100707)2.61757333
16Asymmetry of the thorax (HP:0001555)2.59132829
17Medulloblastoma (HP:0002885)2.58537472
18Deep philtrum (HP:0002002)2.57138930
19Multiple enchondromatosis (HP:0005701)2.56191263
20Abnormality of oral frenula (HP:0000190)2.54740785
21Hyperacusis (HP:0010780)2.51036076
22Spinal cord lesions (HP:0100561)2.49837007
23Syringomyelia (HP:0003396)2.49837007
24Ankle contracture (HP:0006466)2.49707227
25Termporal pattern (HP:0011008)2.44747688
26Insidious onset (HP:0003587)2.44747688
27Trismus (HP:0000211)2.41869983
28Pelvic girdle muscle weakness (HP:0003749)2.40075681
29Carpal bone hypoplasia (HP:0001498)2.37601928
30Abnormality of the anterior horn cell (HP:0006802)2.35902527
31Degeneration of anterior horn cells (HP:0002398)2.35902527
32Basal cell carcinoma (HP:0002671)2.35438877
33Malignant gastrointestinal tract tumors (HP:0006749)2.29532319
34Gastrointestinal carcinoma (HP:0002672)2.29532319
35Spastic diplegia (HP:0001264)2.28154508
36Abnormality of the calcaneus (HP:0008364)2.27853102
37Impulsivity (HP:0100710)2.27521520
38Abnormality of the labia minora (HP:0012880)2.25989580
39Neoplasm of the pancreas (HP:0002894)2.25619622
40Reticulocytopenia (HP:0001896)2.22479913
41Aplasia/hypoplasia of the humerus (HP:0006507)2.20930334
42Abnormality of the umbilical cord (HP:0010881)2.20509187
43Natal tooth (HP:0000695)2.20501707
44Chromsome breakage (HP:0040012)2.18821437
45Microvesicular hepatic steatosis (HP:0001414)2.17996068
46Abnormality of nail color (HP:0100643)2.17804567
47Insomnia (HP:0100785)2.17751460
48Protrusio acetabuli (HP:0003179)2.17081535
49Glioma (HP:0009733)2.16861500
50Oral leukoplakia (HP:0002745)2.16498608
51Distal lower limb amyotrophy (HP:0008944)2.15933423
52Vertebral compression fractures (HP:0002953)2.14477254
53Abnormality of chromosome stability (HP:0003220)2.12393211
54Short nail (HP:0001799)2.11520767
55Absent radius (HP:0003974)2.10869086
56Right ventricular cardiomyopathy (HP:0011663)2.09851422
57Short humerus (HP:0005792)2.09368041
58Missing ribs (HP:0000921)2.08962460
59Dysmetric saccades (HP:0000641)2.08009855
60Orthostatic hypotension (HP:0001278)2.04510985
61Increased density of long bones (HP:0006392)2.02531746
62Metaphyseal cupping (HP:0003021)2.01719162
63Patellar aplasia (HP:0006443)2.01527247
64Osteolytic defects of the hand bones (HP:0009699)2.00681526
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.00681526
66Abnormality of the Achilles tendon (HP:0005109)2.00552072
67Neoplasm of striated muscle (HP:0009728)1.99981480
68Genu recurvatum (HP:0002816)1.99965738
69Acute myeloid leukemia (HP:0004808)1.98055985
70Increased connective tissue (HP:0009025)1.97229168
71Advanced eruption of teeth (HP:0006288)1.95974445
72Abnormal biliary tract morphology (HP:0012440)1.95064064
73Angiofibromas (HP:0010615)1.95014726
74Adenoma sebaceum (HP:0009720)1.95014726
75Shoulder girdle muscle weakness (HP:0003547)1.95005552
76Amaurosis fugax (HP:0100576)1.94708839
77Rectal prolapse (HP:0002035)1.94385394
78Uterine neoplasm (HP:0010784)1.94182867
79Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93460094
80Aplasia/Hypoplasia of the patella (HP:0006498)1.92922722
81Rough bone trabeculation (HP:0100670)1.92254864
82Neoplasm of the oral cavity (HP:0100649)1.92249673
83Myocardial infarction (HP:0001658)1.91712853
84Absent forearm bone (HP:0003953)1.91301474
85Aplasia involving forearm bones (HP:0009822)1.91301474
86Squamous cell carcinoma (HP:0002860)1.91003590
87Cutaneous melanoma (HP:0012056)1.90410664
88Prominent nose (HP:0000448)1.90017290
89Spinal rigidity (HP:0003306)1.89480807
90Premature rupture of membranes (HP:0001788)1.89176119
91Tetraparesis (HP:0002273)1.89148784
92Subacute progressive viral hepatitis (HP:0006572)1.88798107
93Abnormality of the musculature of the pelvis (HP:0001469)1.88269573
94Abnormality of the hip-girdle musculature (HP:0001445)1.88269573
95Abnormality of the salivary glands (HP:0010286)1.87629575
96Atresia of the external auditory canal (HP:0000413)1.86603815
97Abnormalities of placenta or umbilical cord (HP:0001194)1.86246902
98Facial hemangioma (HP:0000329)1.85316635
99Absent thumb (HP:0009777)1.84206681
100Reduced subcutaneous adipose tissue (HP:0003758)1.83921589
101Relative macrocephaly (HP:0004482)1.83569910
102Nephroblastoma (Wilms tumor) (HP:0002667)1.83208940
103Neoplasm of the rectum (HP:0100743)1.83055121
104Leiomyosarcoma (HP:0100243)1.82843328
105Uterine leiomyosarcoma (HP:0002891)1.82843328
106Cafe-au-lait spot (HP:0000957)1.80626816
107Difficulty climbing stairs (HP:0003551)1.80597332
108Abnormality of the distal phalanges of the toes (HP:0010182)1.80302097
109Progressive hearing impairment (HP:0001730)1.79621708
110Increased nuchal translucency (HP:0010880)1.78645210
111Fatigue (HP:0012378)1.77535237
112Glossoptosis (HP:0000162)1.76281363
113Ridged nail (HP:0001807)1.75520875
114Shallow orbits (HP:0000586)1.75499865
115Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75482831
116Distal lower limb muscle weakness (HP:0009053)1.75327549
117Embryonal renal neoplasm (HP:0011794)1.75285609
118High pitched voice (HP:0001620)1.74863969
119Sandal gap (HP:0001852)1.74537409
120Myelodysplasia (HP:0002863)1.74383540
121Sparse lateral eyebrow (HP:0005338)1.73704306
122Fused cervical vertebrae (HP:0002949)1.72936484
123Ovarian neoplasm (HP:0100615)1.72033205
124Onycholysis (HP:0001806)1.71555089
125Abnormal umbilical cord blood vessels (HP:0011403)1.71523642
126Single umbilical artery (HP:0001195)1.71523642
127Abnormality of the fetal cardiovascular system (HP:0010948)1.71523642
128Overriding aorta (HP:0002623)1.71400172
129Long palpebral fissure (HP:0000637)1.70821918
130Neoplasm of the colon (HP:0100273)1.70433046
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.70270460
132Elbow flexion contracture (HP:0002987)1.70176921
133Ulnar bowing (HP:0003031)1.69781413
134Lower limb amyotrophy (HP:0007210)1.69672830
135Upper limb muscle weakness (HP:0003484)1.69582224
136Back pain (HP:0003418)1.69555566
137Aplasia cutis congenita (HP:0001057)1.69464207
138Cervical subluxation (HP:0003308)1.69252439
139Microglossia (HP:0000171)1.69027354
140Abnormal cartilage morphology (HP:0002763)1.68352135
141Delayed puberty (HP:0000823)1.66896311
142Neoplasm of the small intestine (HP:0100833)1.66579129
143Upper motor neuron abnormality (HP:0002127)1.66455417
144Cortical dysplasia (HP:0002539)1.66393744
145Spinal muscular atrophy (HP:0007269)1.65860350
146Overlapping toe (HP:0001845)1.65850510
147Flat acetabular roof (HP:0003180)1.65825183
148Cerebral aneurysm (HP:0004944)1.65401600
149Meckel diverticulum (HP:0002245)1.65308902
150Wrist flexion contracture (HP:0001239)1.64587208
151Volvulus (HP:0002580)1.63702168
152Entropion (HP:0000621)1.62137087
153Ulnar deviation of the wrist (HP:0003049)1.62119947
154Renal cell carcinoma (HP:0005584)1.61936622
155Abnormality of the peritoneum (HP:0002585)1.61913856
156Achilles tendon contracture (HP:0001771)1.61284458
157Abnormality of pyrimidine metabolism (HP:0004353)1.61033064
158Ragged-red muscle fibers (HP:0003200)1.60590536
159Curly hair (HP:0002212)1.59780573
160Abnormality of the preputium (HP:0100587)1.58837026
161Septate vagina (HP:0001153)1.54782426
162Arnold-Chiari malformation (HP:0002308)1.53528022
163Abnormal foot bone ossification (HP:0010675)1.52595872
164Delayed cranial suture closure (HP:0000270)1.51919941
165Generalized amyotrophy (HP:0003700)1.51326580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.15907693
2CDC73.11825086
3NEK22.72356785
4BUB12.70288439
5CDK122.63502821
6EPHA22.61256056
7IRAK32.59593970
8PKN22.57098213
9PBK2.56011815
10SMG12.44230222
11NEK12.29976256
12TTK2.24416069
13EEF2K2.16640493
14LATS12.15115940
15TRIB31.97209517
16SCYL21.96709394
17EIF2AK11.94204190
18MST1R1.93142226
19TSSK61.85227669
20RPS6KA41.83055900
21RPS6KB21.80471540
22PRPF4B1.77172306
23MAP3K101.65947634
24ACVR1B1.64169717
25MAP3K81.60314626
26STK101.55046786
27SRPK11.53582496
28TTN1.50762440
29PLK11.49608683
30ICK1.49358679
31NME21.48856682
32BRSK21.47215470
33CDK41.46670519
34AURKB1.45433982
35MST41.45345138
36PASK1.45187664
37ALK1.44597145
38STK31.42002111
39LATS21.36798506
40EIF2AK31.34895907
41PLK31.25316558
42PLK41.24544816
43DYRK31.22920912
44CDK71.22543275
45CDK61.20733030
46PAK41.20044635
47MAP3K141.15704283
48ATR1.14937082
49CHEK11.13881109
50TGFBR11.11256925
51STK38L1.10894149
52FLT31.08105353
53TESK21.07576358
54LRRK21.03046544
55CHEK21.02590588
56MTOR0.99114002
57STK240.97021796
58MKNK10.95957167
59TLK10.95299726
60TAOK20.94886149
61MAP3K30.92520940
62PIM10.92306698
63PDK30.91667006
64PDK40.91667006
65MELK0.91115193
66CLK10.90731279
67MAPKAPK30.87747545
68STK40.87164411
69MAP3K90.86004194
70MET0.85668201
71BRAF0.85558705
72TAF10.83106872
73NEK90.82326139
74PTK60.82306067
75ATM0.82109839
76SIK10.80847716
77EIF2AK20.79645352
78PAK20.78351513
79AURKA0.78269722
80PTK20.77683025
81KSR20.77595476
82PDGFRA0.77401401
83BMX0.77394689
84MAP2K30.75732269
85CDK20.75715886
86ARAF0.71824980
87FGFR10.71817060
88TESK10.69141076
89MKNK20.66449856
90ZAK0.66077186
91PDK20.66011525
92PNCK0.64334751
93BMPR20.59668153
94MOS0.59364339
95TRPM70.57144966
96MAP4K10.55856871
97BRD40.55144470
98DMPK0.54205357
99FRK0.53274621
100CAMK1D0.52889618
101ERBB40.52794825
102JAK30.51933629
103CSNK2A20.51685432
104NTRK10.51355575
105CDK10.49874156
106RIPK10.49249281
107PAK10.48563993
108MAP3K130.47110544
109BRSK10.47020445
110AKT20.46556408
111RAF10.46252490
112CSNK1E0.45827843
113RPS6KA50.44934093
114MARK30.44052871
115CAMK1G0.43035919
116SIK30.42952536
117CSNK1D0.42599930
118MAP3K110.42392219
119FGFR40.42248547
120DDR20.41903975
121IRAK20.41421922
122PRKCI0.41232100
123CHUK0.41119296
124CDK80.40740797
125MAP3K10.40136565
126ZAP700.39668398
127KSR10.39194685
128MAP3K50.38760670
129CDK90.36398702
130ABL20.36157139
131PRKDC0.35028259
132PDGFRB0.33201610
133CSNK2A10.33122769
134BCKDK0.32408771
135FGFR30.30381506

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77195460
2DNA replication_Homo sapiens_hsa030303.35682774
3RNA transport_Homo sapiens_hsa030133.35035983
4One carbon pool by folate_Homo sapiens_hsa006703.05701660
5Mismatch repair_Homo sapiens_hsa034302.98357848
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71202623
7Spliceosome_Homo sapiens_hsa030402.66685513
8Cell cycle_Homo sapiens_hsa041102.56214690
9Nucleotide excision repair_Homo sapiens_hsa034202.03799568
10RNA polymerase_Homo sapiens_hsa030201.99082786
11Base excision repair_Homo sapiens_hsa034101.88118644
12p53 signaling pathway_Homo sapiens_hsa041151.86983469
13Proteasome_Homo sapiens_hsa030501.83480138
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83112373
15Ribosome_Homo sapiens_hsa030101.72810904
16* mRNA surveillance pathway_Homo sapiens_hsa030151.67987899
17Homologous recombination_Homo sapiens_hsa034401.60217154
18Systemic lupus erythematosus_Homo sapiens_hsa053221.52689090
19Selenocompound metabolism_Homo sapiens_hsa004501.46663927
20Viral carcinogenesis_Homo sapiens_hsa052031.46032299
21Pyrimidine metabolism_Homo sapiens_hsa002401.45329984
22RNA degradation_Homo sapiens_hsa030181.42451949
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33233363
24Antigen processing and presentation_Homo sapiens_hsa046121.32641025
25Fanconi anemia pathway_Homo sapiens_hsa034601.30939212
26Small cell lung cancer_Homo sapiens_hsa052221.27027698
27MicroRNAs in cancer_Homo sapiens_hsa052061.26108014
28Basal transcription factors_Homo sapiens_hsa030221.23824441
29Non-homologous end-joining_Homo sapiens_hsa034501.23489550
30Epstein-Barr virus infection_Homo sapiens_hsa051691.21593224
31Biosynthesis of amino acids_Homo sapiens_hsa012301.17761550
32Legionellosis_Homo sapiens_hsa051341.13393709
33Herpes simplex infection_Homo sapiens_hsa051681.04745614
34HTLV-I infection_Homo sapiens_hsa051661.01282477
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00269294
36Adherens junction_Homo sapiens_hsa045201.00139724
37Thyroid cancer_Homo sapiens_hsa052160.97350632
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96604460
39Vitamin B6 metabolism_Homo sapiens_hsa007500.94825495
40mTOR signaling pathway_Homo sapiens_hsa041500.93783364
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.93092366
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.92992409
43Chronic myeloid leukemia_Homo sapiens_hsa052200.92828789
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91810367
45Pentose phosphate pathway_Homo sapiens_hsa000300.91783112
46Hippo signaling pathway_Homo sapiens_hsa043900.90878818
47Pyruvate metabolism_Homo sapiens_hsa006200.88466355
48Bladder cancer_Homo sapiens_hsa052190.87924591
49TGF-beta signaling pathway_Homo sapiens_hsa043500.86988899
50Apoptosis_Homo sapiens_hsa042100.86147077
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.82821025
52Oocyte meiosis_Homo sapiens_hsa041140.81814491
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80344114
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79857518
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78742634
56Galactose metabolism_Homo sapiens_hsa000520.77039276
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76703827
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76410921
59N-Glycan biosynthesis_Homo sapiens_hsa005100.75635480
60Carbon metabolism_Homo sapiens_hsa012000.74601771
61Proteoglycans in cancer_Homo sapiens_hsa052050.73782665
62Prion diseases_Homo sapiens_hsa050200.73042404
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71851432
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71447117
65Other glycan degradation_Homo sapiens_hsa005110.71199798
66Viral myocarditis_Homo sapiens_hsa054160.71180256
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.69935745
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.69731250
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68211790
70Glioma_Homo sapiens_hsa052140.66981717
71HIF-1 signaling pathway_Homo sapiens_hsa040660.62730011
72Insulin signaling pathway_Homo sapiens_hsa049100.62631507
73VEGF signaling pathway_Homo sapiens_hsa043700.62284836
74Prostate cancer_Homo sapiens_hsa052150.61880100
75ErbB signaling pathway_Homo sapiens_hsa040120.61156071
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60573515
77Hepatitis B_Homo sapiens_hsa051610.59930891
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59924568
79Fructose and mannose metabolism_Homo sapiens_hsa000510.59413104
80Colorectal cancer_Homo sapiens_hsa052100.59221756
81Hepatitis C_Homo sapiens_hsa051600.57386886
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56797645
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56439863
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56332266
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54608193
86Acute myeloid leukemia_Homo sapiens_hsa052210.54256050
87Folate biosynthesis_Homo sapiens_hsa007900.54106047
88Shigellosis_Homo sapiens_hsa051310.53767073
89Tight junction_Homo sapiens_hsa045300.52795016
90Measles_Homo sapiens_hsa051620.51055123
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50787892
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50547750
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.50506001
94Melanoma_Homo sapiens_hsa052180.50116914
95Purine metabolism_Homo sapiens_hsa002300.50072504
96Focal adhesion_Homo sapiens_hsa045100.49746015
97Nitrogen metabolism_Homo sapiens_hsa009100.48906075
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.48677691
99Pancreatic cancer_Homo sapiens_hsa052120.48146106
100Salmonella infection_Homo sapiens_hsa051320.47008433
101Amoebiasis_Homo sapiens_hsa051460.46737764
102B cell receptor signaling pathway_Homo sapiens_hsa046620.46718003
103Basal cell carcinoma_Homo sapiens_hsa052170.46525598
104Toxoplasmosis_Homo sapiens_hsa051450.46269425
105Prolactin signaling pathway_Homo sapiens_hsa049170.44996759
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44968940
107Influenza A_Homo sapiens_hsa051640.44682967
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44145048
109Lysine degradation_Homo sapiens_hsa003100.41840098
110FoxO signaling pathway_Homo sapiens_hsa040680.41314938
111Pathways in cancer_Homo sapiens_hsa052000.40779665
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40731324
113TNF signaling pathway_Homo sapiens_hsa046680.40399482
114Endometrial cancer_Homo sapiens_hsa052130.38938825
115Glutathione metabolism_Homo sapiens_hsa004800.37044252
116Notch signaling pathway_Homo sapiens_hsa043300.36481626
117Non-small cell lung cancer_Homo sapiens_hsa052230.36207544
118Leishmaniasis_Homo sapiens_hsa051400.36086582
119ECM-receptor interaction_Homo sapiens_hsa045120.35990654
120Renal cell carcinoma_Homo sapiens_hsa052110.35396855
121Insulin resistance_Homo sapiens_hsa049310.33924955
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32689149
123AMPK signaling pathway_Homo sapiens_hsa041520.32426483

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