ESYT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.39309707
2cell adhesion mediated by integrin (GO:0033627)4.24604232
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.00274418
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.00274418
5nuclear pore complex assembly (GO:0051292)3.94077457
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74100075
7collagen fibril organization (GO:0030199)3.62545178
8protein localization to endosome (GO:0036010)3.62326601
9endodermal cell differentiation (GO:0035987)3.56801022
10vascular endothelial growth factor signaling pathway (GO:0038084)3.49893140
11antigen processing and presentation of endogenous antigen (GO:0019883)3.40479871
12growth hormone receptor signaling pathway (GO:0060396)3.34409174
13skin morphogenesis (GO:0043589)3.26653188
14protein heterotrimerization (GO:0070208)3.21388666
15negative regulation of fatty acid transport (GO:2000192)3.20339105
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.17805382
17chondrocyte proliferation (GO:0035988)3.14070756
18regulation of histone H3-K27 methylation (GO:0061085)3.12230105
19nuclear pore organization (GO:0006999)3.11981526
20desmosome organization (GO:0002934)3.11758123
21hemidesmosome assembly (GO:0031581)3.10986487
22focal adhesion assembly (GO:0048041)3.10075724
23cell-substrate adherens junction assembly (GO:0007045)3.10075724
24regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.09311688
25mesodermal cell differentiation (GO:0048333)3.08815051
26mannose metabolic process (GO:0006013)3.03466589
27positive regulation of gamma-delta T cell activation (GO:0046645)3.01300610
28apoptotic cell clearance (GO:0043277)2.95207710
29regulation of T cell tolerance induction (GO:0002664)2.95054313
30pinocytosis (GO:0006907)2.94520283
31positive regulation of endothelial cell apoptotic process (GO:2000353)2.93749878
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90006619
33negative regulation of cell killing (GO:0031342)2.90006619
34positive regulation of natural killer cell differentiation (GO:0032825)2.88880766
35positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.87961574
36cellular response to growth hormone stimulus (GO:0071378)2.85731144
37heterotypic cell-cell adhesion (GO:0034113)2.85012520
38cytoskeletal anchoring at plasma membrane (GO:0007016)2.84353565
39positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.84079104
40positive thymic T cell selection (GO:0045059)2.81648906
41pore complex assembly (GO:0046931)2.79478219
42cell-substrate junction assembly (GO:0007044)2.79195238
43negative T cell selection (GO:0043383)2.78727856
44substrate-dependent cell migration (GO:0006929)2.78618335
45response to laminar fluid shear stress (GO:0034616)2.78517256
46cell migration involved in sprouting angiogenesis (GO:0002042)2.75855911
47cytoplasmic mRNA processing body assembly (GO:0033962)2.75195579
48hepatocyte apoptotic process (GO:0097284)2.73271927
49definitive hemopoiesis (GO:0060216)2.73247193
50barbed-end actin filament capping (GO:0051016)2.71788918
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.69907609
52regulation of gamma-delta T cell differentiation (GO:0045586)2.69535135
53regulation of glucose import in response to insulin stimulus (GO:2001273)2.69471784
54positive regulation of histone deacetylation (GO:0031065)2.68455417
55substrate adhesion-dependent cell spreading (GO:0034446)2.66271299
56negative thymic T cell selection (GO:0045060)2.65248083
57regulation of necroptotic process (GO:0060544)2.64798896
58positive regulation of blood vessel endothelial cell migration (GO:0043536)2.63857334
59positive regulation of p38MAPK cascade (GO:1900745)2.63824184
60embryonic process involved in female pregnancy (GO:0060136)2.61419082
61cellular response to vitamin (GO:0071295)2.60873955
62antigen processing and presentation via MHC class Ib (GO:0002475)2.60851769
63response to muramyl dipeptide (GO:0032495)2.60826851
64establishment of endothelial barrier (GO:0061028)2.60289586
65regulation of extracellular matrix disassembly (GO:0010715)2.60083422
66wound healing, spreading of epidermal cells (GO:0035313)2.59940074
67germ cell migration (GO:0008354)2.59467893
68hippo signaling (GO:0035329)2.58652453
69cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.58539996
70response to fluid shear stress (GO:0034405)2.58420526
71regulation of nucleobase-containing compound transport (GO:0032239)2.58202484
72histone H3-K36 demethylation (GO:0070544)2.57932110
73thymic T cell selection (GO:0045061)2.57003962
74retina vasculature morphogenesis in camera-type eye (GO:0061299)2.55949859
75hypotonic response (GO:0006971)2.55862459
76insulin-like growth factor receptor signaling pathway (GO:0048009)2.55355765
77regulation of RNA export from nucleus (GO:0046831)2.55214244
78collagen metabolic process (GO:0032963)2.54161924
79cellular response to vitamin D (GO:0071305)2.51619345
80negative regulation of anoikis (GO:2000811)2.48504458
81stress fiber assembly (GO:0043149)2.47995131
82collagen catabolic process (GO:0030574)2.46851567
83regulation of gamma-delta T cell activation (GO:0046643)2.45772377
84multicellular organismal macromolecule metabolic process (GO:0044259)2.44497450
85JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.44030471
86Golgi transport vesicle coating (GO:0048200)2.43967305
87COPI coating of Golgi vesicle (GO:0048205)2.43967305
88blood vessel endothelial cell migration (GO:0043534)2.43513384
89regulation of interleukin-12 biosynthetic process (GO:0045075)2.43500997
90regulation of transforming growth factor beta2 production (GO:0032909)2.43362993
91negative regulation of necroptotic process (GO:0060546)2.42786439
92regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.42508078
93regulation of anoikis (GO:2000209)2.42035106
94positive regulation of protein import into nucleus, translocation (GO:0033160)2.41337974
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40121332
96protein localization to cell surface (GO:0034394)2.40116086
97membrane raft organization (GO:0031579)2.39884404
98negative regulation of myotube differentiation (GO:0010832)2.39231183
99positive T cell selection (GO:0043368)2.38627386
100low-density lipoprotein particle clearance (GO:0034383)2.37590374
101cellular response to interferon-alpha (GO:0035457)2.37067621
102positive regulation of epithelial to mesenchymal transition (GO:0010718)2.36251942
103positive regulation of tolerance induction (GO:0002645)2.35600482
104iron ion import (GO:0097286)2.35229651
105extracellular matrix disassembly (GO:0022617)2.34313465
106multicellular organismal metabolic process (GO:0044236)2.34061947
107histone H3-K9 demethylation (GO:0033169)2.33524761
108integrin-mediated signaling pathway (GO:0007229)2.33080063
109epithelial cell-cell adhesion (GO:0090136)2.32510162
110surfactant homeostasis (GO:0043129)2.32431756
111multicellular organismal catabolic process (GO:0044243)2.32324065
112positive regulation of keratinocyte differentiation (GO:0045618)2.32204567
113T cell selection (GO:0045058)2.31876390
114platelet-derived growth factor receptor signaling pathway (GO:0048008)2.31869998
115angiogenesis involved in wound healing (GO:0060055)2.31503632
116morphogenesis of an endothelium (GO:0003159)2.31076329
117endothelial tube morphogenesis (GO:0061154)2.31076329
118mRNA transcription (GO:0009299)2.30653649
119positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.30156011
120tyrosine phosphorylation of STAT protein (GO:0007260)2.28872212
121plasma membrane repair (GO:0001778)2.28764980
122vesicle coating (GO:0006901)2.28466510
123regulation of early endosome to late endosome transport (GO:2000641)2.28397819
124positive regulation of receptor recycling (GO:0001921)2.28196567
125membrane protein ectodomain proteolysis (GO:0006509)2.27834928
126adherens junction assembly (GO:0034333)2.27826507
127maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.27647765
128activation of Rac GTPase activity (GO:0032863)2.27342929
129leukocyte tethering or rolling (GO:0050901)2.27154345
130response to interleukin-15 (GO:0070672)2.26643349
131mammary gland epithelial cell proliferation (GO:0033598)2.25924547
132regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.25151688
133positive regulation of extracellular matrix organization (GO:1903055)2.23882334
134interferon-gamma production (GO:0032609)2.22523423
135dosage compensation (GO:0007549)2.22118449
136negative regulation of granulocyte differentiation (GO:0030853)2.21874844
137cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.21505880
138cortical actin cytoskeleton organization (GO:0030866)2.19425748
139peptidyl-threonine modification (GO:0018210)2.18928368
140histone lysine demethylation (GO:0070076)2.18513231
141cell-matrix adhesion (GO:0007160)2.18076464
142positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.18064850
143activation of JUN kinase activity (GO:0007257)2.17705175
144embryonic eye morphogenesis (GO:0048048)2.17663404
145protein retention in ER lumen (GO:0006621)2.13850631
146peptidyl-lysine dimethylation (GO:0018027)2.12620643
147pentose-phosphate shunt (GO:0006098)2.12338350
148positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.12102042
149chondrocyte development (GO:0002063)2.11481530
150germinal center formation (GO:0002467)2.10009996
151negative regulation of protein localization to plasma membrane (GO:1903077)2.09151418
152trophectodermal cell differentiation (GO:0001829)2.09123144
153cellular response to epidermal growth factor stimulus (GO:0071364)2.09023894
154glucocorticoid receptor signaling pathway (GO:0042921)2.08328562
155response to epidermal growth factor (GO:0070849)2.07975269
156bundle of His cell to Purkinje myocyte communication (GO:0086069)2.07963929
157COPII vesicle coating (GO:0048208)2.07781624
158protein hydroxylation (GO:0018126)2.07207319
159histone demethylation (GO:0016577)2.06673030
160positive regulation of granulocyte differentiation (GO:0030854)2.06413552
161regulation of ARF protein signal transduction (GO:0032012)2.06208118
162regulation of necrotic cell death (GO:0010939)2.04371871
163corticosteroid receptor signaling pathway (GO:0031958)2.04172355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.00882284
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.09463656
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.03749516
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.64801833
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.32832512
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.31969023
7CLOCK_20551151_ChIP-Seq_293T_Human2.83525993
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.60784068
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42426665
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36636785
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35367162
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31403491
13VDR_21846776_ChIP-Seq_THP-1_Human2.28271242
14FOXO3_23340844_ChIP-Seq_DLD1_Human2.22002979
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12121895
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.07192236
17ZNF263_19887448_ChIP-Seq_K562_Human2.03881738
18RUNX_20019798_ChIP-Seq_JUKART_Human2.03360041
19PPAR_26484153_Chip-Seq_NCI-H1993_Human2.01937645
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.95056871
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94393063
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94393063
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.90486306
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86342752
25CJUN_26792858_Chip-Seq_BT549_Human1.85500805
26* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85490155
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85247847
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83438354
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.82352778
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82260434
31* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.81779870
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79880800
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79518062
34GATA1_22025678_ChIP-Seq_K562_Human1.78906627
35* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75104237
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.72521246
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71664704
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71170505
39BRD4_25478319_ChIP-Seq_HGPS_Human1.70863068
40RACK7_27058665_Chip-Seq_MCF-7_Human1.69717400
41* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65381879
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64816156
43* MYB_26560356_Chip-Seq_TH2_Human1.60067708
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55987963
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54557284
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.51896001
47TCF7_22412390_ChIP-Seq_EML_Mouse1.47927139
48* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47756012
49* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47550027
50MYC_22102868_ChIP-Seq_BL_Human1.43901264
51* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43678301
52MAF_26560356_Chip-Seq_TH1_Human1.43467012
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.42932703
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41768036
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41200956
56E2F7_22180533_ChIP-Seq_HELA_Human1.40058852
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38842339
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.38837914
59MYB_26560356_Chip-Seq_TH1_Human1.38834504
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37213901
61KDM2B_26808549_Chip-Seq_K562_Human1.36505860
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35426912
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34853362
64SOX2_20726797_ChIP-Seq_SW620_Human1.34136003
65IRF8_27001747_Chip-Seq_BMDM_Mouse1.31820287
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31385827
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31335736
68NCOR1_26117541_ChIP-Seq_K562_Human1.30833832
69LXR_22292898_ChIP-Seq_THP-1_Human1.30425328
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.30182285
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30034115
72SPI1_23127762_ChIP-Seq_K562_Human1.28753386
73* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28733724
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28695334
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28384124
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27896731
77* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27709474
78KDM2B_26808549_Chip-Seq_DND41_Human1.27112408
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.25913581
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24273009
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23823612
82* UTX_26944678_Chip-Seq_JUKART_Human1.23743804
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22903864
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22903864
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22876280
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19050539
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.18891500
88* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18114183
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17583871
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17353588
91* GATA3_27048872_Chip-Seq_THYMUS_Human1.16218354
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14931395
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14623225
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13618014
95ATF3_27146783_Chip-Seq_COLON_Human1.13526378
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13497264
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.11230602
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10491946
99GATA1_19941826_ChIP-Seq_K562_Human1.09498303
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.09237539
101* TBX20_22328084_ChIP-Seq_HEART_Mouse1.08366889
102* TBX20_22080862_ChIP-Seq_HEART_Mouse1.08366889
103TP53_16413492_ChIP-PET_HCT116_Human1.07898332
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07063749
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06540219
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04440741
107VDR_24787735_ChIP-Seq_THP-1_Human1.03930609
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03791502
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03145578
110GATA2_19941826_ChIP-Seq_K562_Human1.01944092
111NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01210705
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.00832939
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00793380
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99782127
115SCL_19346495_ChIP-Seq_HPC-7_Human0.99678554
116* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99089556
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97699310
118PU_27001747_Chip-Seq_BMDM_Mouse0.97170303
119* RUNX1_27514584_Chip-Seq_MCF-7_Human0.97002775
120VDR_24763502_ChIP-Seq_THP-1_Human0.94996049
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.94267668
122GATA6_25053715_ChIP-Seq_YYC3_Human0.94175605
123RUNX1_22412390_ChIP-Seq_EML_Mouse0.92711265
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92414608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.01067240
2MP0005275_abnormal_skin_tensile3.62300654
3MP0003705_abnormal_hypodermis_morpholog3.48601478
4MP0010352_gastrointestinal_tract_polyps3.10317535
5MP0003300_gastrointestinal_ulcer2.88100489
6MP0006054_spinal_hemorrhage2.63757698
7MP0005503_abnormal_tendon_morphology2.50633904
8MP0002166_altered_tumor_susceptibility2.48847840
9MP0002877_abnormal_melanocyte_morpholog2.39149306
10MP0003566_abnormal_cell_adhesion2.38519925
11MP0003279_aneurysm2.25101382
12MP0010234_abnormal_vibrissa_follicle2.21419764
13MP0004272_abnormal_basement_membrane2.18344271
14MP0005409_darkened_coat_color2.16260457
15MP0005623_abnormal_meninges_morphology2.03260376
16MP0002006_tumorigenesis2.02727823
17MP0001958_emphysema1.95188817
18MP0003091_abnormal_cell_migration1.94238704
19MP0005023_abnormal_wound_healing1.93520588
20MP0003191_abnormal_cellular_cholesterol1.89340026
21MP0002060_abnormal_skin_morphology1.83401754
22MP0005076_abnormal_cell_differentiation1.79744493
23MP0002009_preneoplasia1.77755976
24MP0005451_abnormal_body_composition1.71539677
25MP0003045_fibrosis1.59160001
26MP0000733_abnormal_muscle_development1.58186269
27MP0004264_abnormal_extraembryonic_tissu1.50680864
28MP0003763_abnormal_thymus_physiology1.49701376
29MP0000685_abnormal_immune_system1.49131976
30MP0009384_cardiac_valve_regurgitation1.48251526
31MP0004947_skin_inflammation1.47190677
32MP0005058_abnormal_lysosome_morphology1.45814753
33MP0004185_abnormal_adipocyte_glucose1.41782847
34MP0000569_abnormal_digit_pigmentation1.37147578
35MP0002933_joint_inflammation1.36850157
36MP0001851_eye_inflammation1.35259991
37MP0001243_abnormal_dermal_layer1.34450399
38MP0001873_stomach_inflammation1.31594846
39MP0002998_abnormal_bone_remodeling1.29901258
40MP0002254_reproductive_system_inflammat1.28228566
41MP0003453_abnormal_keratinocyte_physiol1.28144577
42MP0004233_abnormal_muscle_weight1.26703447
43MP0003448_altered_tumor_morphology1.26434705
44MP0001879_abnormal_lymphatic_vessel1.23880690
45MP0002896_abnormal_bone_mineralization1.20614206
46MP0001533_abnormal_skeleton_physiology1.20441393
47MP0009278_abnormal_bone_marrow1.18964610
48MP0008260_abnormal_autophagy1.17034730
49MP0004808_abnormal_hematopoietic_stem1.15684616
50MP0005508_abnormal_skeleton_morphology1.14828663
51MP0008057_abnormal_DNA_replication1.14286012
52MP0000767_abnormal_smooth_muscle1.13878611
53MP0010368_abnormal_lymphatic_system1.10563207
54MP0000858_altered_metastatic_potential1.10074260
55MP0010155_abnormal_intestine_physiology1.09455391
56MP0000013_abnormal_adipose_tissue1.08865327
57MP0005621_abnormal_cell_physiology1.08505623
58MP0004782_abnormal_surfactant_physiolog1.08389317
59MP0003724_increased_susceptibility_to1.06105267
60MP0003656_abnormal_erythrocyte_physiolo1.05750796
61MP0000751_myopathy1.04469764
62MP0001849_ear_inflammation1.03395172
63MP0003436_decreased_susceptibility_to1.02699778
64MP0000003_abnormal_adipose_tissue1.02066173
65MP0003303_peritoneal_inflammation1.01915933
66MP0005390_skeleton_phenotype1.00674816
67MP0005501_abnormal_skin_physiology0.99342174
68MP0006138_congestive_heart_failure0.97838341
69MP0001299_abnormal_eye_distance/0.97357745
70MP0005397_hematopoietic_system_phenotyp0.97050842
71MP0001545_abnormal_hematopoietic_system0.97050842
72MP0004087_abnormal_muscle_fiber0.97015281
73MP0003795_abnormal_bone_structure0.96629534
74MP0000465_gastrointestinal_hemorrhage0.96436580
75MP0005666_abnormal_adipose_tissue0.95519297
76MP0005375_adipose_tissue_phenotype0.94587051
77MP0001661_extended_life_span0.94499985
78MP0002168_other_aberrant_phenotype0.92253721
79MP0005387_immune_system_phenotype0.88083086
80MP0001790_abnormal_immune_system0.88083086
81MP0010307_abnormal_tumor_latency0.87934659
82MP0010678_abnormal_skin_adnexa0.87427562
83MP0004381_abnormal_hair_follicle0.87017997
84MP0000759_abnormal_skeletal_muscle0.86846726
85MP0001542_abnormal_bone_strength0.86156779
86MP0003172_abnormal_lysosome_physiology0.85679744
87MP0002925_abnormal_cardiovascular_devel0.85623116
88MP0002295_abnormal_pulmonary_circulatio0.85508691
89MP0002405_respiratory_system_inflammati0.84907806
90MP0002396_abnormal_hematopoietic_system0.84581169
91MP0009840_abnormal_foam_cell0.84548278
92MP0001853_heart_inflammation0.84293972
93MP0002115_abnormal_skeleton_extremities0.84012144
94MP0001835_abnormal_antigen_presentation0.83761269
95MP0009931_abnormal_skin_appearance0.83255043
96MP0002128_abnormal_blood_circulation0.82426177
97MP0000703_abnormal_thymus_morphology0.82128257
98MP0009115_abnormal_fat_cell0.81120894
99MP0002113_abnormal_skeleton_development0.80712007
100MP0008004_abnormal_stomach_pH0.80599676
101MP0003950_abnormal_plasma_membrane0.80587860
102MP0002108_abnormal_muscle_morphology0.79680643
103MP0005165_increased_susceptibility_to0.78466342
104MP0000377_abnormal_hair_follicle0.78322523
105MP0001915_intracranial_hemorrhage0.77908568
106MP0002971_abnormal_brown_adipose0.76890418
107MP0001614_abnormal_blood_vessel0.76877854
108MP0005000_abnormal_immune_tolerance0.76831328
109MP0002398_abnormal_bone_marrow0.76714029
110MP0002452_abnormal_antigen_presenting0.76200723
111MP0001216_abnormal_epidermal_layer0.76049978
112MP0001348_abnormal_lacrimal_gland0.75777641
113MP0004130_abnormal_muscle_cell0.74665137
114MP0005464_abnormal_platelet_physiology0.74390761
115MP0003828_pulmonary_edema0.73468036
116MP0002420_abnormal_adaptive_immunity0.72632280
117MP0000163_abnormal_cartilage_morphology0.72090118
118MP0001819_abnormal_immune_cell0.72073637
119MP0010630_abnormal_cardiac_muscle0.70894518
120MP0005164_abnormal_response_to0.69809145
121MP0005671_abnormal_response_to0.68703953
122MP0004084_abnormal_cardiac_muscle0.68302292
123MP0002419_abnormal_innate_immunity0.68233852
124MP0000249_abnormal_blood_vessel0.68008209
125MP0001800_abnormal_humoral_immune0.67886338
126MP0004883_abnormal_blood_vessel0.67566337
127MP0009333_abnormal_splenocyte_physiolog0.67546664
128MP0000627_abnormal_mammary_gland0.67422170
129MP0002086_abnormal_extraembryonic_tissu0.66989920
130MP0000537_abnormal_urethra_morphology0.65723071
131MP0004134_abnormal_chest_morphology0.65196754
132MP0002796_impaired_skin_barrier0.65107703

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.54197718
2Premature rupture of membranes (HP:0001788)4.51942403
3Aortic dissection (HP:0002647)4.11914294
4Aortic aneurysm (HP:0004942)4.03527034
5Cerebral aneurysm (HP:0004944)3.74024409
6Ankle contracture (HP:0006466)3.68115198
7Cervical subluxation (HP:0003308)3.67080555
8Atrophic scars (HP:0001075)3.46085580
9Osteolytic defects of the hand bones (HP:0009699)3.45095448
10Osteolytic defects of the phalanges of the hand (HP:0009771)3.45095448
11Dilatation of the ascending aorta (HP:0005111)3.36971072
12Shallow orbits (HP:0000586)3.27867832
13Mitral valve prolapse (HP:0001634)3.27867438
14Broad metatarsal (HP:0001783)2.97534872
15Broad face (HP:0000283)2.92697354
16Persistence of primary teeth (HP:0006335)2.85171986
17Peritonitis (HP:0002586)2.83887190
18Absent frontal sinuses (HP:0002688)2.82059386
19Increased connective tissue (HP:0009025)2.71928265
20Increased density of long bones (HP:0006392)2.71804731
21Ankyloglossia (HP:0010296)2.71026071
22Genu recurvatum (HP:0002816)2.68914790
23Distal lower limb amyotrophy (HP:0008944)2.68822538
24Hematochezia (HP:0002573)2.64910805
25Radial bowing (HP:0002986)2.64455372
26Spondylolisthesis (HP:0003302)2.56814433
27Fragile skin (HP:0001030)2.48986241
28Aneurysm (HP:0002617)2.48769106
29Thin bony cortex (HP:0002753)2.47209697
30Rectal prolapse (HP:0002035)2.46079318
31Wormian bones (HP:0002645)2.45793975
32Subacute progressive viral hepatitis (HP:0006572)2.44783360
33Ulnar bowing (HP:0003031)2.40552140
34Hyperacusis (HP:0010780)2.36778006
35Soft skin (HP:0000977)2.35497738
36Increased mean platelet volume (HP:0011877)2.33556796
37Interstitial pulmonary disease (HP:0006530)2.27289769
38Arterial tortuosity (HP:0005116)2.26641191
39Vascular tortuosity (HP:0004948)2.25389802
40Type 1 muscle fiber predominance (HP:0003803)2.24214814
41Blue sclerae (HP:0000592)2.21194362
42Abnormal foot bone ossification (HP:0010675)2.20923681
43Abnormal platelet volume (HP:0011876)2.19354668
44Dysmetric saccades (HP:0000641)2.15817996
45Mesomelia (HP:0003027)2.15388778
46Acute myeloid leukemia (HP:0004808)2.14111996
47Distal lower limb muscle weakness (HP:0009053)2.14040273
48Relative macrocephaly (HP:0004482)2.13149817
49Hypoplastic ischia (HP:0003175)2.11924869
50Abnormality of the ischium (HP:0003174)2.10884913
51Wrist flexion contracture (HP:0001239)2.09435199
52Spinal rigidity (HP:0003306)2.09254242
53Syringomyelia (HP:0003396)2.06254421
54Spinal cord lesions (HP:0100561)2.06254421
55Abnormality of skeletal muscle fiber size (HP:0012084)2.04501490
56Asymmetry of the thorax (HP:0001555)2.03503725
57Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.03452170
58Follicular hyperkeratosis (HP:0007502)2.02700103
59Short nail (HP:0001799)2.01959489
60Right ventricular cardiomyopathy (HP:0011663)2.01680470
61Bowing of the arm (HP:0006488)2.01292792
62Bowed forearm bones (HP:0003956)2.01292792
63Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98378349
64Disproportionate tall stature (HP:0001519)1.98177830
65T lymphocytopenia (HP:0005403)1.97175479
66Abnormality of T cell number (HP:0011839)1.96509704
67Myocardial infarction (HP:0001658)1.96167378
68Glucose intolerance (HP:0000833)1.95835248
69Overgrowth (HP:0001548)1.95399446
70Camptodactyly of toe (HP:0001836)1.94452376
71Centrally nucleated skeletal muscle fibers (HP:0003687)1.94348242
72Tibial bowing (HP:0002982)1.93926600
73Cupped ribs (HP:0000887)1.93649815
74Neonatal short-limb short stature (HP:0008921)1.92732646
75Bladder diverticulum (HP:0000015)1.92524830
76Abnormality of the calcaneus (HP:0008364)1.91204868
77Ectopia lentis (HP:0001083)1.90620480
78Fatigue (HP:0012378)1.89156418
79Scapular winging (HP:0003691)1.87724102
80Narrow palate (HP:0000189)1.86603779
81Macroorchidism (HP:0000053)1.86388335
82Abnormality of the distal phalanx of the thumb (HP:0009617)1.86292349
83Eczematoid dermatitis (HP:0000976)1.85042479
84Milia (HP:0001056)1.84895718
85Epiphyseal dysplasia (HP:0002656)1.84610469
86Abnormality of oral frenula (HP:0000190)1.84214275
87Abnormality of the acetabulum (HP:0003170)1.83112643
88Elbow flexion contracture (HP:0002987)1.82190549
89Mildly elevated creatine phosphokinase (HP:0008180)1.81537279
90Flat acetabular roof (HP:0003180)1.81088752
91Cellulitis (HP:0100658)1.80130682
92Deep philtrum (HP:0002002)1.79967628
93Autoimmune thrombocytopenia (HP:0001973)1.79240088
94Thoracolumbar scoliosis (HP:0002944)1.78565979
95Abnormality of proline metabolism (HP:0010907)1.78177875
96Hydroxyprolinuria (HP:0003080)1.78177875
97Coarse hair (HP:0002208)1.77238164
98Colitis (HP:0002583)1.75875767
99Lower limb amyotrophy (HP:0007210)1.74498587
100Abnormality of the fingertips (HP:0001211)1.74459062
101Enlarged penis (HP:0000040)1.74082608
102Heterotopia (HP:0002282)1.73695770
103Joint laxity (HP:0001388)1.73040866
104Broad ribs (HP:0000885)1.72357110
105Short 4th metacarpal (HP:0010044)1.71734975
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71734975
107Abnormal vertebral ossification (HP:0100569)1.71353101
108Aortic regurgitation (HP:0001659)1.71329142
109Advanced eruption of teeth (HP:0006288)1.70873356
110Abnormality of the frontal sinuses (HP:0002687)1.70333709
111Abnormality of the radial head (HP:0003995)1.70063138
112Bicuspid aortic valve (HP:0001647)1.69261457
113Dislocated radial head (HP:0003083)1.69139353
114Mitral regurgitation (HP:0001653)1.68622732
115Slender build (HP:0001533)1.68477792
116Striae distensae (HP:0001065)1.68323703
117Abnormality of the thoracic spine (HP:0100711)1.68226722
118Vertebral arch anomaly (HP:0008438)1.66124478
119Increased IgE level (HP:0003212)1.66018519
120Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.65764534
121Sparse lateral eyebrow (HP:0005338)1.65680074
122Distal upper limb amyotrophy (HP:0007149)1.65395727
123Upper limb amyotrophy (HP:0009129)1.65395727
124Nonimmune hydrops fetalis (HP:0001790)1.64736828
125Abnormality of the distal phalanges of the toes (HP:0010182)1.64525923
126Abnormality of the peritoneum (HP:0002585)1.64190269
127Polycythemia (HP:0001901)1.63480751
128Hyporeflexia of lower limbs (HP:0002600)1.63044099
129Viral hepatitis (HP:0006562)1.62651854
130Obstructive sleep apnea (HP:0002870)1.61988581
131Limited elbow extension (HP:0001377)1.61792147
132Spinal cord compression (HP:0002176)1.61598982
133Abnormal glucose tolerance (HP:0001952)1.60432109
134Bowel diverticulosis (HP:0005222)1.60344109
135Delayed closure of the anterior fontanelle (HP:0001476)1.60217044
136Hyperextensible skin (HP:0000974)1.59840493
137Abnormal ossification of hand bones (HP:0005921)1.59734908
138Increased variability in muscle fiber diameter (HP:0003557)1.59664575
139Vertebral compression fractures (HP:0002953)1.59314858
140Micronodular cirrhosis (HP:0001413)1.58583305
141Exercise-induced myalgia (HP:0003738)1.57856275
142Mitral stenosis (HP:0001718)1.56960857
143Hypoplasia of the iris (HP:0007676)1.56039367
144Craniofacial hyperostosis (HP:0004493)1.55278088
145Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.54802251
146Achilles tendon contracture (HP:0001771)1.53575908
147Severe short stature (HP:0003510)1.52228790
148Slow saccadic eye movements (HP:0000514)1.51468877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.56089320
2TTN3.44645435
3TRIB32.97063135
4PKN22.58602666
5FRK2.45799759
6LATS12.37458687
7ICK2.33484472
8JAK32.19654963
9PDGFRA2.17552974
10SMG12.06216505
11TRPM72.00101448
12FGFR41.98558710
13STK101.97184555
14TIE11.96445279
15FGFR31.96212010
16DDR21.95010193
17PTK61.90698713
18RIPK11.89315082
19EEF2K1.84191782
20MAP3K61.79236510
21MAP3K131.75716547
22LRRK21.70470514
23JAK11.68425568
24IRAK31.64917703
25CAMK1D1.64597551
26ITK1.63685229
27EPHB11.57336622
28SIK11.56844417
29DMPK1.53521133
30TGFBR21.53259891
31MAP4K11.50002097
32STK31.48688279
33NUAK11.45652411
34FGFR21.45541188
35PDGFRB1.44484721
36MAP3K101.42327938
37SCYL21.36073252
38BMX1.34409254
39KSR21.31399976
40PTK21.30529381
41TYK21.28788637
42EPHA31.27986906
43ERN11.26686029
44CDK61.19687536
45PAK21.19345243
46TXK1.18534039
47TEC1.17871836
48NLK1.17217579
49MAP3K141.14490307
50CDK121.10294089
51RIPK41.07460847
52MARK21.05289701
53LATS21.04432085
54CAMK1G1.03919622
55NEK91.03916240
56FER1.03750258
57RPS6KA41.03623171
58MST41.02824392
59TGFBR11.01776810
60BRD41.01541074
61CSK1.00726274
62TBK10.97351670
63STK380.94858395
64EPHA20.94226306
65FLT30.91383722
66MAP3K30.90754465
67MAP3K10.90521332
68ZAP700.85169969
69IKBKE0.84818376
70HIPK20.83701641
71FGFR10.83185297
72MELK0.83144352
73MTOR0.82907755
74MAP3K20.82407332
75CDC42BPA0.81490170
76BTK0.79987570
77MAPK110.79824387
78RET0.79819165
79PDPK10.78707931
80PRKCH0.77498696
81PAK40.76624222
82MST1R0.75236671
83MAP2K30.74298191
84MARK30.73958427
85JAK20.73451003
86WNK10.72710837
87BMPR20.71953215
88KDR0.71944370
89PRKG20.70965010
90SGK30.70393426
91MAPK120.70140153
92NEK60.69106731
93CHUK0.68455750
94MAP3K70.67703554
95RPS6KB20.67417417
96TAOK30.66722520
97PIK3CA0.65453745
98HCK0.65045398
99MOS0.64855508
100CDK90.64217978
101LCK0.64005085
102LMTK20.63648236
103INSR0.63298171
104PDK10.63123511
105CDK40.60277088
106MET0.59408777
107AKT30.58697070
108PAK30.57167378
109PIM10.54716531
110TYRO30.54568397
111PIK3CG0.52261664
112IKBKB0.50486320
113ILK0.49680618
114MAPK70.49659505
115DYRK1B0.49602994
116EGFR0.49107087
117PRKAA20.48922749
118RPS6KA20.48345096
119YES10.48053955
120TAOK20.46430744
121ERBB30.46314955
122ROCK10.46204149
123PTK2B0.46063990
124IGF1R0.46032452
125BLK0.45042487
126PRKD20.44462597
127MYLK0.44341812
128PRKCQ0.44062793
129MAPKAPK30.43172453
130FES0.42814074
131KIT0.41724521
132RAF10.41513728
133MAP3K80.40544282
134GSK3A0.40403408
135GRK60.39659247
136PRKD10.39657933
137ABL10.39504587
138STK240.38942437
139CSF1R0.38410676
140RPS6KL10.37837960
141RPS6KC10.37837960
142KSR10.33608108

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.69418733
2Focal adhesion_Homo sapiens_hsa045102.32776753
3Small cell lung cancer_Homo sapiens_hsa052221.98086796
4Adherens junction_Homo sapiens_hsa045201.89467536
5Other glycan degradation_Homo sapiens_hsa005111.81109546
6Proteoglycans in cancer_Homo sapiens_hsa052051.80756436
7Leukocyte transendothelial migration_Homo sapiens_hsa046701.79977795
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79693056
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.75710831
10Toxoplasmosis_Homo sapiens_hsa051451.68690821
11Chronic myeloid leukemia_Homo sapiens_hsa052201.67560472
12Osteoclast differentiation_Homo sapiens_hsa043801.56033377
13Viral myocarditis_Homo sapiens_hsa054161.52759792
14Amoebiasis_Homo sapiens_hsa051461.52603464
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48907036
16Platelet activation_Homo sapiens_hsa046111.48304747
17Pancreatic cancer_Homo sapiens_hsa052121.45165515
18Leishmaniasis_Homo sapiens_hsa051401.42525424
19T cell receptor signaling pathway_Homo sapiens_hsa046601.40502176
20TNF signaling pathway_Homo sapiens_hsa046681.39874005
21Malaria_Homo sapiens_hsa051441.38719660
22MicroRNAs in cancer_Homo sapiens_hsa052061.36268104
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.36047555
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34404975
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29284980
26ErbB signaling pathway_Homo sapiens_hsa040121.28524460
27Antigen processing and presentation_Homo sapiens_hsa046121.28522022
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28195289
29TGF-beta signaling pathway_Homo sapiens_hsa043501.28031105
30Measles_Homo sapiens_hsa051621.28030552
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27412975
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26697959
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22222022
34Prostate cancer_Homo sapiens_hsa052151.18758275
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17989541
36Protein digestion and absorption_Homo sapiens_hsa049741.17767592
37Hematopoietic cell lineage_Homo sapiens_hsa046401.16699724
38Primary immunodeficiency_Homo sapiens_hsa053401.16424950
39Inositol phosphate metabolism_Homo sapiens_hsa005621.16419658
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.14503264
41Insulin resistance_Homo sapiens_hsa049311.10955154
42Hepatitis B_Homo sapiens_hsa051611.10880320
43GnRH signaling pathway_Homo sapiens_hsa049121.10775107
44Shigellosis_Homo sapiens_hsa051311.10490740
45Choline metabolism in cancer_Homo sapiens_hsa052311.10280974
46Apoptosis_Homo sapiens_hsa042101.10103982
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08633456
48PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07757693
49Notch signaling pathway_Homo sapiens_hsa043301.06739540
50Acute myeloid leukemia_Homo sapiens_hsa052211.06089297
51Insulin signaling pathway_Homo sapiens_hsa049101.05740385
52mTOR signaling pathway_Homo sapiens_hsa041500.99744638
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.99731332
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98867410
55Dilated cardiomyopathy_Homo sapiens_hsa054140.98862109
56Pentose phosphate pathway_Homo sapiens_hsa000300.96070091
57Bladder cancer_Homo sapiens_hsa052190.95997748
58HTLV-I infection_Homo sapiens_hsa051660.94653505
59Renal cell carcinoma_Homo sapiens_hsa052110.93969931
60FoxO signaling pathway_Homo sapiens_hsa040680.93393011
61Endometrial cancer_Homo sapiens_hsa052130.93102269
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91512714
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91418888
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91234370
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90216954
66Prolactin signaling pathway_Homo sapiens_hsa049170.89210008
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89046335
68B cell receptor signaling pathway_Homo sapiens_hsa046620.88965350
69Rap1 signaling pathway_Homo sapiens_hsa040150.88745319
70Salmonella infection_Homo sapiens_hsa051320.88483642
71Dorso-ventral axis formation_Homo sapiens_hsa043200.87513207
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.87227069
73Viral carcinogenesis_Homo sapiens_hsa052030.86653137
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.86650107
75VEGF signaling pathway_Homo sapiens_hsa043700.86558083
76Pathways in cancer_Homo sapiens_hsa052000.86298774
77Colorectal cancer_Homo sapiens_hsa052100.85117965
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84883198
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82284084
80Hippo signaling pathway_Homo sapiens_hsa043900.81131520
81Chemokine signaling pathway_Homo sapiens_hsa040620.80991382
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79283555
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78738765
84Non-small cell lung cancer_Homo sapiens_hsa052230.78468120
85Hepatitis C_Homo sapiens_hsa051600.78230544
86HIF-1 signaling pathway_Homo sapiens_hsa040660.78078986
87Glioma_Homo sapiens_hsa052140.77783877
88Thyroid cancer_Homo sapiens_hsa052160.76541347
89p53 signaling pathway_Homo sapiens_hsa041150.75717123
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.74213466
91Graft-versus-host disease_Homo sapiens_hsa053320.73994315
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73507965
93Caffeine metabolism_Homo sapiens_hsa002320.70782331
94Legionellosis_Homo sapiens_hsa051340.70698145
95Long-term potentiation_Homo sapiens_hsa047200.70686954
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70348292
97Tuberculosis_Homo sapiens_hsa051520.69489066
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.68981455
99Tight junction_Homo sapiens_hsa045300.68883333
100Endocytosis_Homo sapiens_hsa041440.68142544
101Influenza A_Homo sapiens_hsa051640.67440213
102Pertussis_Homo sapiens_hsa051330.66866907
103Prion diseases_Homo sapiens_hsa050200.65482743
104AMPK signaling pathway_Homo sapiens_hsa041520.64412570
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62828142
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62795707
107Melanoma_Homo sapiens_hsa052180.62166116
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61786955
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59698683
110Herpes simplex infection_Homo sapiens_hsa051680.59276503
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.58690348
112Estrogen signaling pathway_Homo sapiens_hsa049150.57462750
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56738269
114Lysine degradation_Homo sapiens_hsa003100.55719908
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.55155990
116MAPK signaling pathway_Homo sapiens_hsa040100.53277700
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51918360
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51623896
119Glucagon signaling pathway_Homo sapiens_hsa049220.51623090
120Thyroid hormone synthesis_Homo sapiens_hsa049180.46956734

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