ESRRAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of amino acid transport (GO:0051957)9.72185683
2negative regulation of amino acid transport (GO:0051956)9.42836216
3phospholipid scrambling (GO:0017121)8.43499830
4negative regulation of neurotransmitter transport (GO:0051589)7.76593925
5regulation of glutamate secretion (GO:0014048)7.16492459
6serotonin receptor signaling pathway (GO:0007210)7.04401200
7regulation of dopamine secretion (GO:0014059)6.07675420
8mannose metabolic process (GO:0006013)5.61991691
9DNA replication checkpoint (GO:0000076)5.59249671
10cullin deneddylation (GO:0010388)5.18066324
11muscle cell fate commitment (GO:0042693)5.14493302
12ribosome assembly (GO:0042255)5.00045493
13positive regulation of amine transport (GO:0051954)4.93481358
14pharyngeal system development (GO:0060037)4.93413225
15branched-chain amino acid catabolic process (GO:0009083)4.73815530
16N-glycan processing (GO:0006491)4.54977652
17intestinal epithelial cell development (GO:0060576)4.52511455
18negative regulation of activin receptor signaling pathway (GO:0032926)4.52135323
19protein deneddylation (GO:0000338)4.48536347
20regulation of amino acid transport (GO:0051955)4.44329378
21positive regulation of organic acid transport (GO:0032892)4.38677934
22response to pheromone (GO:0019236)4.27083838
23pyrimidine-containing compound transmembrane transport (GO:0072531)4.26453546
24epithelial cell fate commitment (GO:0072148)4.11045671
25negative regulation of organic acid transport (GO:0032891)4.07649170
26meiotic chromosome segregation (GO:0045132)3.93552002
27negative regulation of protein tyrosine kinase activity (GO:0061099)3.92280042
28spermatid development (GO:0007286)3.86748595
29negative regulation of amine transport (GO:0051953)3.75949548
30branched-chain amino acid metabolic process (GO:0009081)3.73907940
31regulation of membrane lipid distribution (GO:0097035)3.71537085
32multicellular organism reproduction (GO:0032504)3.70543396
33piRNA metabolic process (GO:0034587)3.58695609
34synapsis (GO:0007129)3.56395070
35sperm motility (GO:0030317)3.50841110
36response to nitrosative stress (GO:0051409)3.48846395
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.48348882
38interferon-gamma production (GO:0032609)3.44453237
39epithelial cilium movement (GO:0003351)3.43442322
40outer ear morphogenesis (GO:0042473)3.42963061
41microtubule nucleation (GO:0007020)3.39458491
42early endosome to late endosome transport (GO:0045022)3.22357703
43long-term synaptic potentiation (GO:0060291)3.19121224
44axonemal dynein complex assembly (GO:0070286)3.19048274
45urogenital system development (GO:0001655)3.18233641
46acrosome reaction (GO:0007340)3.16552568
47formation of translation preinitiation complex (GO:0001731)3.10541971
48regulation of catecholamine secretion (GO:0050433)3.07241398
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04052246
50protein import into peroxisome matrix (GO:0016558)3.03245027
51male meiosis (GO:0007140)3.01945051
52aggressive behavior (GO:0002118)3.01419697
53DNA methylation involved in gamete generation (GO:0043046)2.96095987
54atrial septum morphogenesis (GO:0060413)2.89569034
55actin filament capping (GO:0051693)2.89357713
56cilium or flagellum-dependent cell motility (GO:0001539)2.88034705
57base-excision repair, AP site formation (GO:0006285)2.85567772
58forebrain morphogenesis (GO:0048853)2.84659673
59organic cation transport (GO:0015695)2.82029762
60motile cilium assembly (GO:0044458)2.81980235
61positive regulation of systemic arterial blood pressure (GO:0003084)2.80632513
62chromosome organization involved in meiosis (GO:0070192)2.79428672
63regulation of cardioblast proliferation (GO:0003264)2.79157265
64regulation of secondary heart field cardioblast proliferation (GO:0003266)2.79157265
65sperm-egg recognition (GO:0035036)2.75863389
66proteasome assembly (GO:0043248)2.75688302
67mucosal-associated lymphoid tissue development (GO:0048537)2.75647069
68Peyers patch development (GO:0048541)2.75647069
69otic vesicle formation (GO:0030916)2.74387937
70protein polyglutamylation (GO:0018095)2.74268018
71positive regulation of action potential (GO:0045760)2.68463257
72negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.66950525
73cAMP catabolic process (GO:0006198)2.66380357
74negative regulation of mast cell activation (GO:0033004)2.66059554
75reproduction (GO:0000003)2.61477523
76pathway-restricted SMAD protein phosphorylation (GO:0060389)2.60041110
77DNA double-strand break processing (GO:0000729)2.58228987
78somatic hypermutation of immunoglobulin genes (GO:0016446)2.55688123
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55688123
80cilium movement (GO:0003341)2.54665784
81germ cell development (GO:0007281)2.53624691
82L-fucose catabolic process (GO:0042355)2.51863303
83fucose catabolic process (GO:0019317)2.51863303
84L-fucose metabolic process (GO:0042354)2.51863303
85positive regulation of RNA splicing (GO:0033120)2.50959848
86negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.49539222
87lung-associated mesenchyme development (GO:0060484)2.44396691
88negative regulation of synaptic transmission (GO:0050805)2.44255033
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.42898177
90telencephalon development (GO:0021537)2.42833272
91reflex (GO:0060004)2.40979773
92binding of sperm to zona pellucida (GO:0007339)2.39167591
93labyrinthine layer development (GO:0060711)2.38593521
94female gonad development (GO:0008585)2.38529149
95negative regulation of actin filament depolymerization (GO:0030835)2.37268482
96mitotic G2/M transition checkpoint (GO:0044818)2.35045158
97interkinetic nuclear migration (GO:0022027)2.34507338
98regulation of urine volume (GO:0035809)2.33193749
99positive regulation of catecholamine secretion (GO:0033605)11.8787521
100negative regulation of neurotransmitter secretion (GO:0046929)10.4336036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.77919570
2VDR_22108803_ChIP-Seq_LS180_Human3.75285185
3ZNF274_21170338_ChIP-Seq_K562_Hela3.28229359
4GBX2_23144817_ChIP-Seq_PC3_Human3.27743288
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.13503043
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.05962216
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.86130729
8FUS_26573619_Chip-Seq_HEK293_Human2.76703614
9EWS_26573619_Chip-Seq_HEK293_Human2.56913197
10P300_19829295_ChIP-Seq_ESCs_Human2.42667665
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36168699
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.34391409
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23789609
14UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.14885446
15ER_23166858_ChIP-Seq_MCF-7_Human2.11382484
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08204760
17EZH2_22144423_ChIP-Seq_EOC_Human1.96844706
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94161986
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88445347
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82673747
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.82067097
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.73465595
23TOP2B_26459242_ChIP-Seq_MCF-7_Human1.69529916
24RNF2_27304074_Chip-Seq_NSC_Mouse1.68134419
25RUNX2_22187159_ChIP-Seq_PCA_Human1.63575718
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60705902
27SMAD4_21799915_ChIP-Seq_A2780_Human1.59469794
28TP53_22573176_ChIP-Seq_HFKS_Human1.58909080
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58847930
30AR_25329375_ChIP-Seq_VCAP_Human1.58542380
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56858195
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56672029
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53703303
34PRDM14_20953172_ChIP-Seq_ESCs_Human1.53342480
35SOX2_19829295_ChIP-Seq_ESCs_Human1.52135117
36NANOG_19829295_ChIP-Seq_ESCs_Human1.52135117
37SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50555390
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47838933
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47717103
40CBP_20019798_ChIP-Seq_JUKART_Human1.47717103
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46787197
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46721572
43TCF4_22108803_ChIP-Seq_LS180_Human1.43490831
44TAF15_26573619_Chip-Seq_HEK293_Human1.41427211
45BCAT_22108803_ChIP-Seq_LS180_Human1.40766371
46STAT3_23295773_ChIP-Seq_U87_Human1.40549934
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40481258
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39739742
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39059281
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38197654
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38197654
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.37778222
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36703310
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36082750
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35974079
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.33751540
57TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33212051
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32634256
59KDM2B_26808549_Chip-Seq_REH_Human1.30905193
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29025596
61HTT_18923047_ChIP-ChIP_STHdh_Human1.27009960
62IRF1_19129219_ChIP-ChIP_H3396_Human1.26034571
63TCF4_23295773_ChIP-Seq_U87_Human1.25466839
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24459649
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22780126
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21927195
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19828204
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18150748
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.18150748
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17832509
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15302074
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14898073
73PHF8_20622853_ChIP-Seq_HELA_Human1.14172749
74TBL1_22424771_ChIP-Seq_293T_Human1.13992424
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13903253
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13606780
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.13172527
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.11085258
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.10707337
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10315148
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.10100596
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.10084102
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09705002
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09702088
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09494421
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08706357
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06892793
88NFYB_21822215_ChIP-Seq_K562_Human1.06078507
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05350323
90ETV1_20927104_ChIP-Seq_GIST48_Human1.05179891
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04600359
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02743139
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.02348798
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00515573
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00494624
96NCOR_22424771_ChIP-Seq_293T_Human0.99738171
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.99734097
98MYC_18940864_ChIP-ChIP_HL60_Human0.99680903
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.98054775
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96075436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008961_abnormal_basal_metabolism5.89266993
2MP0002822_catalepsy4.87515525
3MP0002234_abnormal_pharynx_morphology3.60806058
4MP0005410_abnormal_fertilization3.53022653
5MP0004782_abnormal_surfactant_physiolog2.97298089
6MP0002396_abnormal_hematopoietic_system2.61896058
7MP0003656_abnormal_erythrocyte_physiolo2.50545607
8MP0002735_abnormal_chemical_nociception2.44170089
9MP0004215_abnormal_myocardial_fiber2.37158398
10MP0004484_altered_response_of2.37139844
11MP0003806_abnormal_nucleotide_metabolis2.15044884
12MP0005167_abnormal_blood-brain_barrier2.14365630
13MP0008058_abnormal_DNA_repair1.99231499
14MP0002160_abnormal_reproductive_system1.98585783
15MP0000049_abnormal_middle_ear1.96945656
16MP0001486_abnormal_startle_reflex1.71865017
17MP0003136_yellow_coat_color1.69445546
18MP0002837_dystrophic_cardiac_calcinosis1.67748604
19MP0005551_abnormal_eye_electrophysiolog1.67338294
20MP0003646_muscle_fatigue1.67284618
21MP0001664_abnormal_digestion1.66474534
22MP0008877_abnormal_DNA_methylation1.60743380
23MP0003828_pulmonary_edema1.58221768
24MP0008995_early_reproductive_senescence1.57628009
25MP0003698_abnormal_male_reproductive1.56259458
26MP0003878_abnormal_ear_physiology1.51190103
27MP0005377_hearing/vestibular/ear_phenot1.51190103
28MP0004808_abnormal_hematopoietic_stem1.47826971
29MP0001963_abnormal_hearing_physiology1.41483246
30MP0001929_abnormal_gametogenesis1.40585114
31MP0005389_reproductive_system_phenotype1.38224280
32MP0003567_abnormal_fetal_cardiomyocyte1.37351236
33MP0008775_abnormal_heart_ventricle1.37248094
34MP0006292_abnormal_olfactory_placode1.36473823
35MP0003880_abnormal_central_pattern1.35172245
36MP0008057_abnormal_DNA_replication1.34700782
37MP0002102_abnormal_ear_morphology1.33824742
38MP0001968_abnormal_touch/_nociception1.32063242
39MP0003718_maternal_effect1.27529383
40MP0010094_abnormal_chromosome_stability1.26323571
41MP0005423_abnormal_somatic_nervous1.25826365
42MP0004043_abnormal_pH_regulation1.23510892
43MP0009745_abnormal_behavioral_response1.21163779
44MP0001529_abnormal_vocalization1.20774598
45MP0000613_abnormal_salivary_gland1.19952207
46MP0002163_abnormal_gland_morphology1.18025373
47MP0000678_abnormal_parathyroid_gland1.16716205
48MP0009250_abnormal_appendicular_skeleto1.13430848
49MP0002249_abnormal_larynx_morphology1.11420839
50MP0005379_endocrine/exocrine_gland_phen1.10919826
51MP0001485_abnormal_pinna_reflex1.09144194
52MP0005084_abnormal_gallbladder_morpholo1.07619753
53MP0001986_abnormal_taste_sensitivity1.05149573
54MP0004084_abnormal_cardiac_muscle1.01974455
55MP0009697_abnormal_copulation1.00113650
56MP0002210_abnormal_sex_determination0.99344375
57MP0003119_abnormal_digestive_system0.94387535
58MP0010368_abnormal_lymphatic_system0.93749052
59MP0006054_spinal_hemorrhage0.93277142
60MP0008932_abnormal_embryonic_tissue0.93134247
61MP0006036_abnormal_mitochondrial_physio0.90786119
62MP0001145_abnormal_male_reproductive0.89845249
63MP0003786_premature_aging0.89419281
64MP0004142_abnormal_muscle_tone0.89185884
65MP0005595_abnormal_vascular_smooth0.88372938
66MP0002736_abnormal_nociception_after0.87755981
67MP0000383_abnormal_hair_follicle0.86387445
68MP0008875_abnormal_xenobiotic_pharmacok0.85782279
69MP0000653_abnormal_sex_gland0.85525008
70MP0005248_abnormal_Harderian_gland0.85490642
71MP0003755_abnormal_palate_morphology0.84026642
72MP0005253_abnormal_eye_physiology0.82889720
73MP0003077_abnormal_cell_cycle0.81665033
74MP0002733_abnormal_thermal_nociception0.81284437
75MP0004885_abnormal_endolymph0.80873719
76MP0002272_abnormal_nervous_system0.80152759
77MP0004085_abnormal_heartbeat0.79393581
78MP0003937_abnormal_limbs/digits/tail_de0.76956386
79MP0005646_abnormal_pituitary_gland0.76782791
80MP0000026_abnormal_inner_ear0.76261459
81MP0002277_abnormal_respiratory_mucosa0.75693154
82MP0002233_abnormal_nose_morphology0.74814017
83MP0004957_abnormal_blastocyst_morpholog0.74366549
84MP0000920_abnormal_myelination0.73809428
85MP0003868_abnormal_feces_composition0.71879095
86MP0003935_abnormal_craniofacial_develop0.71263328
87MP0002161_abnormal_fertility/fecundity0.71258742
88MP0001984_abnormal_olfaction0.70701404
89MP0001501_abnormal_sleep_pattern0.69284467
90MP0001764_abnormal_homeostasis0.68750861
91MP0001346_abnormal_lacrimal_gland0.68435144
92MP0002132_abnormal_respiratory_system0.68306217
93MP0002127_abnormal_cardiovascular_syste0.67274411
94MP0006276_abnormal_autonomic_nervous0.62359533
95MP0002653_abnormal_ependyma_morphology0.62112504
96MP0003938_abnormal_ear_development0.61673116
97MP0001970_abnormal_pain_threshold0.61294440
98MP0000163_abnormal_cartilage_morphology0.61221291
99MP0002090_abnormal_vision0.59755444
100MP0000647_abnormal_sebaceous_gland0.59726652

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)5.44795256
2Abnormality of the renal collecting system (HP:0004742)4.97302810
3Decreased circulating renin level (HP:0003351)4.75338026
4Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.52666529
5Short 1st metacarpal (HP:0010034)4.52666529
6Ketosis (HP:0001946)4.46847473
7Polydipsia (HP:0001959)4.44782175
8Abnormal drinking behavior (HP:0030082)4.44782175
9Absent/shortened dynein arms (HP:0200106)4.11227469
10Dynein arm defect of respiratory motile cilia (HP:0012255)4.11227469
11Abnormal rod and cone electroretinograms (HP:0008323)4.00074845
12Abnormality of the 1st metacarpal (HP:0010009)3.98473789
13Abnormality of the intrinsic pathway (HP:0010989)3.90271440
14Attenuation of retinal blood vessels (HP:0007843)3.78270766
15Increased hepatocellular lipid droplets (HP:0006565)3.71874493
16Lipid accumulation in hepatocytes (HP:0006561)3.71752026
17Renal Fanconi syndrome (HP:0001994)3.42450338
18Nephronophthisis (HP:0000090)3.15206902
19Cerebral edema (HP:0002181)3.10597797
20Polyuria (HP:0000103)3.05956891
21Stenosis of the external auditory canal (HP:0000402)2.97130033
22Cerebellar dysplasia (HP:0007033)2.97059066
23Abnormal ciliary motility (HP:0012262)2.95178414
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91651741
25Duplicated collecting system (HP:0000081)2.88420650
26Abnormality of urine glucose concentration (HP:0011016)2.85603130
27Glycosuria (HP:0003076)2.85603130
28Abnormality of renin-angiotensin system (HP:0000847)2.83063182
29Abnormality of cochlea (HP:0000375)2.82005615
30Abnormal respiratory motile cilium morphology (HP:0005938)2.75359693
31Abnormal respiratory epithelium morphology (HP:0012253)2.75359693
32Fused cervical vertebrae (HP:0002949)2.66230292
33Short phalanx of the thumb (HP:0009660)2.64527745
34Chronic hepatic failure (HP:0100626)2.62386947
35Constricted visual fields (HP:0001133)2.62383354
36Abnormal respiratory motile cilium physiology (HP:0012261)2.62110786
37Abnormal urine output (HP:0012590)2.62051520
38Menorrhagia (HP:0000132)2.53236320
39Short hallux (HP:0010109)2.50566104
40Abnormality of midbrain morphology (HP:0002418)2.46978631
41Molar tooth sign on MRI (HP:0002419)2.46978631
42Large for gestational age (HP:0001520)2.43976883
43True hermaphroditism (HP:0010459)2.42198202
44Exertional dyspnea (HP:0002875)2.39926780
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37806991
46Abnormality of the renal medulla (HP:0100957)2.37348709
47Abolished electroretinogram (ERG) (HP:0000550)2.37188399
48Aplasia/Hypoplasia of the hallux (HP:0008362)2.34133148
49Pancreatic fibrosis (HP:0100732)2.30096476
50Widely spaced teeth (HP:0000687)2.28694624
51Lip pit (HP:0100267)2.28650915
52Morphological abnormality of the inner ear (HP:0011390)2.28223028
53Pancreatitis (HP:0001733)2.27765628
54Hyperglycinemia (HP:0002154)2.27581899
55Pendular nystagmus (HP:0012043)2.23130776
56Pancreatic cysts (HP:0001737)2.21630854
57Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.21486715
58Abnormality of renal resorption (HP:0011038)2.20190990
59Medial flaring of the eyebrow (HP:0010747)2.18817020
60Increased intramyocellular lipid droplets (HP:0012240)2.17866229
61Abnormality of renal excretion (HP:0011036)2.16656908
62Methylmalonic acidemia (HP:0002912)2.12067922
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10659304
64Optic disc pallor (HP:0000543)2.10481199
65Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.05026254
66Vertebral hypoplasia (HP:0008417)2.05026254
67Abnormality of the common coagulation pathway (HP:0010990)2.02897700
68Adactyly (HP:0009776)2.00298296
69Lethargy (HP:0001254)1.99509922
70Broad-based gait (HP:0002136)1.99235821
71Chorioretinal atrophy (HP:0000533)1.98231568
72Increased muscle lipid content (HP:0009058)1.95549412
73Hypomagnesemia (HP:0002917)1.95289235
74Brushfield spots (HP:0001088)1.94800392
75Cupped ear (HP:0000378)1.91842765
76Abnormal biliary tract morphology (HP:0012440)1.89987306
77Renal dysplasia (HP:0000110)1.89690976
78Cone-rod dystrophy (HP:0000548)1.89464062
79Respiratory difficulties (HP:0002880)1.89246751
80Congenital stationary night blindness (HP:0007642)1.89015794
81Decreased central vision (HP:0007663)1.86974742
82Bony spicule pigmentary retinopathy (HP:0007737)1.85918560
83Supernumerary spleens (HP:0009799)1.84764462
84Hypoplasia of the uterus (HP:0000013)1.82980845
85Intestinal atresia (HP:0011100)1.82012979
86Recurrent corneal erosions (HP:0000495)1.81203034
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.74320314
88Carpal bone hypoplasia (HP:0001498)1.72918753
89Abnormality of serum amino acid levels (HP:0003112)1.71989654
90Male pseudohermaphroditism (HP:0000037)1.70267874
91Asplenia (HP:0001746)1.67812849
92Dyskinesia (HP:0100660)1.66986119
93Sloping forehead (HP:0000340)1.65119178
94Horizontal nystagmus (HP:0000666)1.64341125
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.64123197
96Chronic sinusitis (HP:0011109)1.62459396
97Female pseudohermaphroditism (HP:0010458)1.62297704
98Occipital encephalocele (HP:0002085)1.61496208
99Lactic acidosis (HP:0003128)1.61213923
100Limb hypertonia (HP:0002509)1.60427119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK36.19655487
2PINK12.47787699
3FRK2.30836446
4PBK2.07341468
5BCKDK12.5563067
6EIF2AK21.76846303
7PLK41.66250191
8TAOK31.60747213
9ZAK1.47577170
10WNK41.41599966
11BUB11.35345068
12INSRR1.33312354
13TGFBR21.26769706
14GRK11.24883033
15STK391.24095258
16MST41.05949910
17MAP3K131.04878771
18MAP2K71.04550143
19CCNB10.85714364
20ADRBK20.85493152
21MARK30.83242458
22STK380.82588510
23MAP4K20.79978868
24PRKG20.78778241
25GRK70.77152820
26CSNK1A1L0.76809658
27OXSR10.73237643
28CDK190.70107783
29RPS6KA40.70100523
30MKNK10.67558376
31MAP3K40.66755486
32TNK20.66579494
33MAPK130.65824018
34ERBB30.63861958
35MAP2K60.62662902
36GRK50.62422547
37STK38L0.61883674
38OBSCN0.59571328
39PRKCE0.56032413
40MKNK20.55503211
41BRSK20.54805916
42NUAK10.54803159
43BLK0.53985576
44MYLK0.50656514
45EPHA30.50087910
46CSNK1G30.49322165
47CHUK0.46473679
48WNK30.46452911
49AKT20.45388077
50ATR0.44890478
51PRKCQ0.44863816
52CSNK1G10.44682095
53PLK20.43481089
54ABL10.38699381
55NEK20.37218180
56CSNK1G20.37121123
57VRK10.36617434
58RPS6KA50.36231952
59IKBKB0.35955422
60KIT0.35641721
61PLK10.34361298
62RPS6KB10.34260884
63MAPK70.32241537
64ATM0.32145830
65EPHA40.29884767
66TIE10.28652865
67SGK20.28600081
68TXK0.28076000
69STK30.27483533
70BMPR1B0.26803496
71DYRK20.26519275
72INSR0.26159773
73MUSK0.25519909
74EGFR0.24988464
75NTRK20.24847596
76PASK0.24723698
77TLK10.24684316
78RPS6KA60.24529115
79CDK80.24250350
80STK160.24102598
81PLK30.23936628
82PKN10.22779507
83PHKG20.21750597
84PHKG10.21750597
85TGFBR10.21565192
86FGFR20.21556883
87CDC70.21137526
88PRKCG0.20776372
89FLT30.20538753
90TNIK0.20456144
91PAK30.20426955
92SRPK10.19679271
93PRKG10.19562290
94CSNK1A10.19439399
95CSNK1D0.18593389
96SGK4940.18016438
97SGK2230.18016438
98STK110.17777371
99ADRBK10.16973317
100CAMK40.16937805

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006404.97195210
2Sulfur relay system_Homo sapiens_hsa041224.74908772
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.21153771
4Olfactory transduction_Homo sapiens_hsa047402.45016124
5Starch and sucrose metabolism_Homo sapiens_hsa005001.93025136
6Salivary secretion_Homo sapiens_hsa049701.87559197
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82986531
8Fanconi anemia pathway_Homo sapiens_hsa034601.82062991
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81784737
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80495457
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72717861
12Retinol metabolism_Homo sapiens_hsa008301.70785117
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67531938
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57026456
15Taste transduction_Homo sapiens_hsa047421.56744909
16Non-homologous end-joining_Homo sapiens_hsa034501.55266583
17Butanoate metabolism_Homo sapiens_hsa006501.55217320
18Linoleic acid metabolism_Homo sapiens_hsa005911.52965588
19N-Glycan biosynthesis_Homo sapiens_hsa005101.52954677
20Peroxisome_Homo sapiens_hsa041461.47004894
21Hedgehog signaling pathway_Homo sapiens_hsa043401.46988513
22Nitrogen metabolism_Homo sapiens_hsa009101.45342990
23Folate biosynthesis_Homo sapiens_hsa007901.45068343
24Phototransduction_Homo sapiens_hsa047441.43425412
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42399420
26Renin secretion_Homo sapiens_hsa049241.37008852
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35586057
28Serotonergic synapse_Homo sapiens_hsa047261.34726316
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.31579605
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28808293
31One carbon pool by folate_Homo sapiens_hsa006701.24608876
32RNA transport_Homo sapiens_hsa030131.24357964
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22956999
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19736658
35ABC transporters_Homo sapiens_hsa020101.18434575
36Basal transcription factors_Homo sapiens_hsa030221.16984941
37RNA degradation_Homo sapiens_hsa030181.16680782
38Fatty acid biosynthesis_Homo sapiens_hsa000611.15027780
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14656076
40Chemical carcinogenesis_Homo sapiens_hsa052041.14139307
41Tryptophan metabolism_Homo sapiens_hsa003801.13601047
42Oocyte meiosis_Homo sapiens_hsa041141.13004927
43Calcium signaling pathway_Homo sapiens_hsa040201.09941240
44Gap junction_Homo sapiens_hsa045401.06189626
45Morphine addiction_Homo sapiens_hsa050321.06173286
46Homologous recombination_Homo sapiens_hsa034401.05319243
47Circadian entrainment_Homo sapiens_hsa047131.05141580
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.05107459
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05024672
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98238324
51Base excision repair_Homo sapiens_hsa034100.98144579
52Fatty acid degradation_Homo sapiens_hsa000710.96010141
53Purine metabolism_Homo sapiens_hsa002300.94510117
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90920620
55cAMP signaling pathway_Homo sapiens_hsa040240.86051330
56Caffeine metabolism_Homo sapiens_hsa002320.84001769
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82987698
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79985407
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.78251105
60Mineral absorption_Homo sapiens_hsa049780.78176121
61Fatty acid elongation_Homo sapiens_hsa000620.77429239
62Ovarian steroidogenesis_Homo sapiens_hsa049130.76886098
63Selenocompound metabolism_Homo sapiens_hsa004500.75664479
64Gastric acid secretion_Homo sapiens_hsa049710.75003631
65Ether lipid metabolism_Homo sapiens_hsa005650.72609689
66Fatty acid metabolism_Homo sapiens_hsa012120.70969064
67Nicotine addiction_Homo sapiens_hsa050330.69915268
68Glutamatergic synapse_Homo sapiens_hsa047240.69504903
69Arachidonic acid metabolism_Homo sapiens_hsa005900.69091791
70Vitamin digestion and absorption_Homo sapiens_hsa049770.66681511
71Metabolic pathways_Homo sapiens_hsa011000.62881688
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62237311
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61938659
74GABAergic synapse_Homo sapiens_hsa047270.61509558
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61399283
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58484639
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58206345
78mRNA surveillance pathway_Homo sapiens_hsa030150.56703600
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56185784
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53991408
81Basal cell carcinoma_Homo sapiens_hsa052170.52969742
82Insulin secretion_Homo sapiens_hsa049110.51923697
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49979086
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48630835
85Cell cycle_Homo sapiens_hsa041100.48028189
86TGF-beta signaling pathway_Homo sapiens_hsa043500.47420154
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.47193469
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.45037899
89Dorso-ventral axis formation_Homo sapiens_hsa043200.44759354
90Arginine and proline metabolism_Homo sapiens_hsa003300.38832368
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37503119
92Circadian rhythm_Homo sapiens_hsa047100.36449767
93beta-Alanine metabolism_Homo sapiens_hsa004100.36086006
94Spliceosome_Homo sapiens_hsa030400.34988200
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34769130
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34711389
97Bile secretion_Homo sapiens_hsa049760.34448132
98Nucleotide excision repair_Homo sapiens_hsa034200.31751141
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30505157
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29690455

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