ERVMER34-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.63609898
2chaperone-mediated protein transport (GO:0072321)5.38073973
3chromatin remodeling at centromere (GO:0031055)4.79838134
4ATP synthesis coupled proton transport (GO:0015986)4.76959948
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.76959948
6CENP-A containing nucleosome assembly (GO:0034080)4.70134177
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.68780627
8establishment of integrated proviral latency (GO:0075713)4.55610118
9proteasome assembly (GO:0043248)4.47858886
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.39431293
11termination of RNA polymerase III transcription (GO:0006386)4.39431293
12rRNA modification (GO:0000154)4.38278411
13pseudouridine synthesis (GO:0001522)4.37505993
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.23005136
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.14666108
16protein complex biogenesis (GO:0070271)4.13388244
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.11284741
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.11284741
19NADH dehydrogenase complex assembly (GO:0010257)4.11284741
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.10612927
21mitochondrial respiratory chain complex assembly (GO:0033108)4.06082628
22regulation of mitotic spindle checkpoint (GO:1903504)4.05290833
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.05290833
24regulation of mitochondrial translation (GO:0070129)3.97089589
25respiratory electron transport chain (GO:0022904)3.95900838
26histone exchange (GO:0043486)3.94995395
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.92469559
28electron transport chain (GO:0022900)3.88877499
29respiratory chain complex IV assembly (GO:0008535)3.87928789
30DNA replication checkpoint (GO:0000076)3.87007859
31DNA double-strand break processing (GO:0000729)3.76715067
32spliceosomal snRNP assembly (GO:0000387)3.73658604
33DNA replication-independent nucleosome organization (GO:0034724)3.67581614
34DNA replication-independent nucleosome assembly (GO:0006336)3.67581614
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67192662
36rRNA methylation (GO:0031167)3.65618039
37DNA strand elongation involved in DNA replication (GO:0006271)3.63292783
38purine nucleobase biosynthetic process (GO:0009113)3.60116909
39maturation of 5.8S rRNA (GO:0000460)3.58377779
40negative regulation of ligase activity (GO:0051352)3.57467912
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57467912
42protein neddylation (GO:0045116)3.54705050
43protein targeting to mitochondrion (GO:0006626)3.53111679
44cytochrome complex assembly (GO:0017004)3.51360694
45regulation of helicase activity (GO:0051095)3.49976790
46telomere maintenance via semi-conservative replication (GO:0032201)3.49003448
47nucleobase biosynthetic process (GO:0046112)3.46922541
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44227744
49establishment of viral latency (GO:0019043)3.44170541
50DNA strand elongation (GO:0022616)3.43814578
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35754601
52histone mRNA metabolic process (GO:0008334)3.35339446
53establishment of protein localization to mitochondrion (GO:0072655)3.28625581
54regulation of nuclear cell cycle DNA replication (GO:0033262)3.25370525
55water-soluble vitamin biosynthetic process (GO:0042364)3.23042161
56IMP biosynthetic process (GO:0006188)3.20639551
57protein localization to mitochondrion (GO:0070585)3.19912045
58ribosome assembly (GO:0042255)3.19297914
59DNA damage response, detection of DNA damage (GO:0042769)3.16367296
60protein complex localization (GO:0031503)3.15167608
61rRNA processing (GO:0006364)3.12878929
62ribosomal small subunit assembly (GO:0000028)3.12713415
63cellular protein complex localization (GO:0034629)3.11895558
64regulation of cellular amino acid metabolic process (GO:0006521)3.10558443
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08125435
66negative regulation of mitotic sister chromatid separation (GO:2000816)3.08125435
67negative regulation of sister chromatid segregation (GO:0033046)3.08125435
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08125435
69negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08125435
70mitotic metaphase plate congression (GO:0007080)3.07872647
71negative regulation of DNA-dependent DNA replication (GO:2000104)3.07838306
72DNA replication-dependent nucleosome assembly (GO:0006335)3.07193302
73DNA replication-dependent nucleosome organization (GO:0034723)3.07193302
74telomere maintenance via telomerase (GO:0007004)3.04547033
75rRNA metabolic process (GO:0016072)3.02288296
76negative regulation of chromosome segregation (GO:0051985)3.01835774
777-methylguanosine mRNA capping (GO:0006370)3.01352256
78telomere maintenance via telomere lengthening (GO:0010833)2.99597599
79protein localization to kinetochore (GO:0034501)2.98276935
80telomere maintenance via recombination (GO:0000722)2.97166870
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.96931376
82DNA catabolic process, exonucleolytic (GO:0000738)2.96566391
83regulation of posttranscriptional gene silencing (GO:0060147)2.95902988
84regulation of gene silencing by miRNA (GO:0060964)2.95902988
85regulation of gene silencing by RNA (GO:0060966)2.95902988
86DNA-templated transcription, termination (GO:0006353)2.94639291
877-methylguanosine RNA capping (GO:0009452)2.94043665
88RNA capping (GO:0036260)2.94043665
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92256063
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91870170
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91870170
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91870170
93maturation of SSU-rRNA (GO:0030490)2.89792232
94peptidyl-histidine modification (GO:0018202)2.88364044
95L-serine metabolic process (GO:0006563)2.87896812
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87699081
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.87699081
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87429232
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87429232
100transcription-coupled nucleotide-excision repair (GO:0006283)2.85266756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.39974316
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.10449154
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.34287131
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.21882500
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.07548068
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.86344066
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32657529
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.20728702
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18400698
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06696719
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.04460157
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.95228415
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93920856
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69232740
15ELK1_19687146_ChIP-ChIP_HELA_Human2.65727246
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58049014
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53241300
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43731979
19FOXP3_21729870_ChIP-Seq_TREG_Human2.37749357
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37338274
21VDR_23849224_ChIP-Seq_CD4+_Human2.31080296
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27826006
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22048934
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15728970
25DCP1A_22483619_ChIP-Seq_HELA_Human1.98084593
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93075785
27YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90745504
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90255977
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90126567
30TTF2_22483619_ChIP-Seq_HELA_Human1.88482741
31MYC_18940864_ChIP-ChIP_HL60_Human1.85975160
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.85233268
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84685022
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.84294098
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81576590
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.77276110
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75500326
38XRN2_22483619_ChIP-Seq_HELA_Human1.70601477
39EWS_26573619_Chip-Seq_HEK293_Human1.69857547
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.64341411
41GABP_19822575_ChIP-Seq_HepG2_Human1.64311593
42AR_21909140_ChIP-Seq_LNCAP_Human1.63164499
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53269058
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52889026
45NANOG_16153702_ChIP-ChIP_HESCs_Human1.51439315
46VDR_22108803_ChIP-Seq_LS180_Human1.50737445
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48336604
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48152932
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47554355
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46826893
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44814204
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43292046
53FUS_26573619_Chip-Seq_HEK293_Human1.42961022
54ZNF274_21170338_ChIP-Seq_K562_Hela1.42532852
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38843560
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.38092156
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.37540844
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36760969
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.34561600
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34412801
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33739513
62ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31520379
63IGF1R_20145208_ChIP-Seq_DFB_Human1.29233173
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20505186
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18412340
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18320545
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18320545
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18320545
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13273883
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12324731
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10609031
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08630876
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.08454671
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03634594
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.01499051
76KDM5A_27292631_Chip-Seq_BREAST_Human0.99645121
77TP63_19390658_ChIP-ChIP_HaCaT_Human0.98778822
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96735233
79ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90615286
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87445551
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82446657
82ELF5_23300383_ChIP-Seq_T47D_Human0.82029553
83P300_19829295_ChIP-Seq_ESCs_Human0.81149176
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80521591
85PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80089831
86NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78109760
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78030801
88IRF1_19129219_ChIP-ChIP_H3396_Human0.77332162
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76390965
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74228145
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74030939
92TP53_22573176_ChIP-Seq_HFKS_Human0.73556773
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71466834
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71430157
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.71413660
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71040419
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69981049
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69563468
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.69411761
100TAF15_26573619_Chip-Seq_HEK293_Human0.67661413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.13456021
2MP0003941_abnormal_skin_development4.12926536
3MP0004957_abnormal_blastocyst_morpholog3.66280707
4MP0008058_abnormal_DNA_repair3.44590805
5MP0010094_abnormal_chromosome_stability3.40739123
6MP0006292_abnormal_olfactory_placode3.40079465
7MP0003111_abnormal_nucleus_morphology3.12270794
8MP0003718_maternal_effect2.74567258
9MP0008877_abnormal_DNA_methylation2.41155581
10MP0008057_abnormal_DNA_replication2.40319749
11MP0003077_abnormal_cell_cycle2.37075264
12MP0008932_abnormal_embryonic_tissue2.28216330
13MP0001293_anophthalmia2.22630072
14MP0008007_abnormal_cellular_replicative2.12038702
15MP0002254_reproductive_system_inflammat2.09170373
16MP0002938_white_spotting2.09002705
17MP0009697_abnormal_copulation2.00184201
18MP0009379_abnormal_foot_pigmentation1.99179441
19MP0003136_yellow_coat_color1.99177997
20MP0001529_abnormal_vocalization1.92442780
21MP0001188_hyperpigmentation1.89292267
22MP0006035_abnormal_mitochondrial_morpho1.84036100
23MP0003806_abnormal_nucleotide_metabolis1.80075462
24MP0006072_abnormal_retinal_apoptosis1.78481258
25MP0003786_premature_aging1.76977933
26MP0006036_abnormal_mitochondrial_physio1.71982609
27MP0003186_abnormal_redox_activity1.66267836
28MP0002736_abnormal_nociception_after1.64614789
29MP0003567_abnormal_fetal_cardiomyocyte1.60052959
30MP0000372_irregular_coat_pigmentation1.50955652
31MP0003011_delayed_dark_adaptation1.40917822
32MP0002277_abnormal_respiratory_mucosa1.38796084
33MP0003937_abnormal_limbs/digits/tail_de1.37170241
34MP0002102_abnormal_ear_morphology1.37073500
35MP0004133_heterotaxia1.35469236
36MP0000579_abnormal_nail_morphology1.30740584
37MP0002160_abnormal_reproductive_system1.27962586
38MP0003890_abnormal_embryonic-extraembry1.27442651
39MP0008789_abnormal_olfactory_epithelium1.15814761
40MP0003315_abnormal_perineum_morphology1.14346040
41MP0001730_embryonic_growth_arrest1.12018452
42MP0002653_abnormal_ependyma_morphology1.10591576
43MP0005084_abnormal_gallbladder_morpholo1.09955500
44MP0000350_abnormal_cell_proliferation1.09859118
45MP0001968_abnormal_touch/_nociception1.09263167
46MP0002085_abnormal_embryonic_tissue1.08412607
47MP0008872_abnormal_physiological_respon1.07765650
48MP0009672_abnormal_birth_weight1.07680013
49MP0002210_abnormal_sex_determination1.07631151
50MP0005075_abnormal_melanosome_morpholog1.07068355
51MP0003119_abnormal_digestive_system1.05823914
52MP0008995_early_reproductive_senescence1.05075749
53MP0005551_abnormal_eye_electrophysiolog1.04742272
54MP0001697_abnormal_embryo_size1.04421900
55MP0005253_abnormal_eye_physiology1.04364370
56MP0005645_abnormal_hypothalamus_physiol1.03482597
57MP0000049_abnormal_middle_ear1.01867103
58MP0001984_abnormal_olfaction1.01626391
59MP0000631_abnormal_neuroendocrine_gland0.99587607
60MP0001145_abnormal_male_reproductive0.98535968
61MP0002233_abnormal_nose_morphology0.98496665
62MP0001286_abnormal_eye_development0.98354101
63MP0001929_abnormal_gametogenesis0.95370694
64MP0003195_calcinosis0.95249980
65MP0005389_reproductive_system_phenotype0.94687395
66MP0002751_abnormal_autonomic_nervous0.93796814
67MP0000653_abnormal_sex_gland0.92204493
68MP0002697_abnormal_eye_size0.92188449
69MP0001764_abnormal_homeostasis0.90809956
70MP0002796_impaired_skin_barrier0.90726778
71MP0001485_abnormal_pinna_reflex0.90501763
72MP0002084_abnormal_developmental_patter0.89629241
73MP0002090_abnormal_vision0.89331957
74MP0002111_abnormal_tail_morphology0.89287523
75MP0003121_genomic_imprinting0.89287161
76MP0004147_increased_porphyrin_level0.87681216
77MP0005380_embryogenesis_phenotype0.86744624
78MP0001672_abnormal_embryogenesis/_devel0.86744624
79MP0001919_abnormal_reproductive_system0.83484281
80MP0002234_abnormal_pharynx_morphology0.83328263
81MP0001727_abnormal_embryo_implantation0.81729339
82MP0002080_prenatal_lethality0.81579835
83MP0005377_hearing/vestibular/ear_phenot0.80055931
84MP0003878_abnormal_ear_physiology0.80055931
85MP0000647_abnormal_sebaceous_gland0.77789733
86MP0003938_abnormal_ear_development0.77577025
87MP0003698_abnormal_male_reproductive0.76936531
88MP0005174_abnormal_tail_pigmentation0.76820585
89MP0005395_other_phenotype0.76696532
90MP0002095_abnormal_skin_pigmentation0.74618415
91MP0010030_abnormal_orbit_morphology0.73058628
92MP0004215_abnormal_myocardial_fiber0.72742455
93MP0000313_abnormal_cell_death0.71699751
94MP0005391_vision/eye_phenotype0.69301292
95MP0003984_embryonic_growth_retardation0.68227659
96MP0002088_abnormal_embryonic_growth/wei0.67722973
97MP0005187_abnormal_penis_morphology0.67021170
98MP0005394_taste/olfaction_phenotype0.66972455
99MP0005499_abnormal_olfactory_system0.66972455
100MP0009703_decreased_birth_body0.66918829

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.39539342
2Increased hepatocellular lipid droplets (HP:0006565)4.25206092
3Acute encephalopathy (HP:0006846)4.05593992
4Lipid accumulation in hepatocytes (HP:0006561)3.92731977
5Mitochondrial inheritance (HP:0001427)3.85373082
6Abnormal mitochondria in muscle tissue (HP:0008316)3.77081803
7Progressive macrocephaly (HP:0004481)3.61343540
8Increased CSF lactate (HP:0002490)3.57975669
9Oral leukoplakia (HP:0002745)3.36285848
10Colon cancer (HP:0003003)3.33391133
11Renal Fanconi syndrome (HP:0001994)3.25450771
12Hepatocellular necrosis (HP:0001404)3.15883368
13Aplastic anemia (HP:0001915)3.14118256
14Cerebral edema (HP:0002181)2.97338225
15Abnormality of the labia minora (HP:0012880)2.97142584
16Abnormal number of erythroid precursors (HP:0012131)2.89001906
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88765821
18Septo-optic dysplasia (HP:0100842)2.84280249
19Meckel diverticulum (HP:0002245)2.84144264
20Methylmalonic acidemia (HP:0002912)2.79857169
21Pendular nystagmus (HP:0012043)2.73807547
22Birth length less than 3rd percentile (HP:0003561)2.73802039
23Abnormality of the ileum (HP:0001549)2.72937702
24Abnormal lung lobation (HP:0002101)2.68898428
25Hepatic necrosis (HP:0002605)2.64635380
26Homocystinuria (HP:0002156)2.64569431
27Abnormality of homocysteine metabolism (HP:0010919)2.64569431
28Pancreatic cysts (HP:0001737)2.59993544
29Multiple enchondromatosis (HP:0005701)2.58378738
30Abnormality of cells of the erythroid lineage (HP:0012130)2.57148163
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54781618
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54781618
33Increased serum lactate (HP:0002151)2.53800163
34Pancreatic islet-cell hyperplasia (HP:0004510)2.52593742
35Abnormality of methionine metabolism (HP:0010901)2.52540589
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51401568
37Abnormality of the preputium (HP:0100587)2.50325313
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.47471780
39Macrocytic anemia (HP:0001972)2.46440098
40Chromsome breakage (HP:0040012)2.45512552
41Lactic acidosis (HP:0003128)2.42575252
42Abnormality of serum amino acid levels (HP:0003112)2.40802378
43Abnormality of chromosome stability (HP:0003220)2.40049803
44Bilateral microphthalmos (HP:0007633)2.39941336
45Pancreatic fibrosis (HP:0100732)2.39596417
46Exertional dyspnea (HP:0002875)2.39457624
47Methylmalonic aciduria (HP:0012120)2.38813984
48Type I transferrin isoform profile (HP:0003642)2.36150203
49Megaloblastic anemia (HP:0001889)2.35460972
50Increased intramyocellular lipid droplets (HP:0012240)2.34828384
51Congenital, generalized hypertrichosis (HP:0004540)2.29325228
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28646414
53Reticulocytopenia (HP:0001896)2.26847482
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25817231
55Abnormality of alanine metabolism (HP:0010916)2.25817231
56Hyperalaninemia (HP:0003348)2.25817231
57Sparse eyelashes (HP:0000653)2.23982819
583-Methylglutaconic aciduria (HP:0003535)2.23388868
59Hypoglycemic seizures (HP:0002173)2.21692523
60Respiratory difficulties (HP:0002880)2.21118884
61Leukodystrophy (HP:0002415)2.18960188
62Hyperglycinemia (HP:0002154)2.18841594
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13744281
64Hyperinsulinemic hypoglycemia (HP:0000825)2.13367398
65Respiratory failure (HP:0002878)2.12893354
66Cellular immunodeficiency (HP:0005374)2.12051156
67Hyperglycinuria (HP:0003108)2.09467525
68Exercise intolerance (HP:0003546)2.08781961
69Lethargy (HP:0001254)2.08537560
70Optic disc pallor (HP:0000543)2.07831772
71Hypoplasia of the pons (HP:0012110)2.05565914
72Pancytopenia (HP:0001876)2.02417911
73Duodenal stenosis (HP:0100867)2.00531176
74Small intestinal stenosis (HP:0012848)2.00531176
75Abnormality of renal resorption (HP:0011038)2.00405242
76True hermaphroditism (HP:0010459)2.00255587
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98963191
78Abnormal protein N-linked glycosylation (HP:0012347)1.98963191
79Abnormal protein glycosylation (HP:0012346)1.98963191
80Abnormal glycosylation (HP:0012345)1.98963191
81Abnormality of the pons (HP:0007361)1.98153047
82Abnormality of glycine metabolism (HP:0010895)1.97671426
83Abnormality of serine family amino acid metabolism (HP:0010894)1.97671426
84Confusion (HP:0001289)1.96929009
85Facial cleft (HP:0002006)1.95689988
86Cleft eyelid (HP:0000625)1.94672864
87Absent septum pellucidum (HP:0001331)1.92091481
88Abnormality of sulfur amino acid metabolism (HP:0004339)1.87333747
89Increased muscle lipid content (HP:0009058)1.86560426
90Selective tooth agenesis (HP:0001592)1.86331761
91Microvesicular hepatic steatosis (HP:0001414)1.86099260
92Reduced antithrombin III activity (HP:0001976)1.86090315
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85354885
94Optic nerve hypoplasia (HP:0000609)1.84642904
95Absent thumb (HP:0009777)1.83732138
96Symptomatic seizures (HP:0011145)1.83395169
97Abnormality of the duodenum (HP:0002246)1.80476526
98Abnormality of the septum pellucidum (HP:0007375)1.80454216
99Abolished electroretinogram (ERG) (HP:0000550)1.78017281
100Rough bone trabeculation (HP:0100670)1.76644479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.41626659
2BUB14.21266622
3CDC73.82041190
4PBK3.77897923
5MST43.17894600
6SRPK12.64487053
7ZAK2.59263544
8NME12.40542556
9VRK12.39754020
10EIF2AK32.31863851
11TTK2.29066151
12STK162.27189923
13TAF12.25239872
14TNIK2.24168663
15PLK32.08608763
16NUAK11.96424907
17MKNK21.90862144
18WNK31.84214532
19EIF2AK11.79183401
20WEE11.72470453
21PLK41.69774851
22MKNK11.67898677
23TSSK61.63955367
24TRIM281.62761203
25DYRK31.62748034
26DYRK21.59743150
27NEK11.51009959
28PLK11.50307159
29BMPR1B1.48717874
30NME21.47444328
31BRSK21.29710250
32STK38L1.15539925
33CHEK21.12994626
34CSNK1G11.09628041
35GRK11.08810608
36PINK11.06673715
37STK31.06247871
38ADRBK21.03205102
39ATR1.02989559
40EIF2AK20.97862523
41OXSR10.93614771
42AURKB0.90694435
43CSNK1G30.87240568
44BCKDK0.85781949
45TLK10.84842569
46NEK20.81143180
47MAP4K20.81134296
48CSNK1G20.78112997
49STK40.75557570
50ACVR1B0.73865160
51ALK0.71892604
52FRK0.69461006
53MAP3K120.68256344
54CSNK1A1L0.62793799
55CDK70.62103069
56ATM0.61807149
57CASK0.61737040
58CSNK2A10.61581781
59INSRR0.60161900
60CSNK2A20.58655963
61RPS6KA40.57923833
62STK390.57374034
63CHEK10.55105993
64RPS6KA50.52361192
65CDK190.50947137
66CSNK1E0.49968666
67BRSK10.49715827
68LATS10.49046908
69PAK40.48677841
70AURKA0.46838210
71PNCK0.45947434
72DAPK10.45872791
73CLK10.43853734
74CSNK1A10.43639911
75TIE10.43413086
76PRKCG0.40652069
77PDK20.40452017
78CDK30.40234722
79CDK10.39381364
80PLK20.37806821
81WNK40.37589301
82BCR0.36471496
83MAPKAPK30.36119908
84KDR0.36084219
85NLK0.35003188
86PASK0.34912529
87MAP2K70.34823641
88ERBB40.34783745
89PRKCI0.34341675
90RPS6KB20.32279097
91ERBB30.31411419
92PRKDC0.29165701
93FGFR10.27973654
94MAPKAPK50.27719798
95PRKCE0.27078293
96CDK20.26793908
97MUSK0.26053788
98ABL20.24557816
99MAP3K40.22627973
100PIM10.22529623

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.21519082
2RNA polymerase_Homo sapiens_hsa030203.63774089
3Oxidative phosphorylation_Homo sapiens_hsa001903.36393711
4Ribosome_Homo sapiens_hsa030103.24501849
5DNA replication_Homo sapiens_hsa030303.23264796
6Mismatch repair_Homo sapiens_hsa034303.22003261
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18084174
8Parkinsons disease_Homo sapiens_hsa050122.95489082
9Homologous recombination_Homo sapiens_hsa034402.75544482
10Protein export_Homo sapiens_hsa030602.37917403
11Spliceosome_Homo sapiens_hsa030402.37602262
12One carbon pool by folate_Homo sapiens_hsa006702.22914351
13Huntingtons disease_Homo sapiens_hsa050162.20964014
14RNA degradation_Homo sapiens_hsa030182.08788644
15Base excision repair_Homo sapiens_hsa034102.04556991
16RNA transport_Homo sapiens_hsa030131.97860333
17Basal transcription factors_Homo sapiens_hsa030221.95435331
18Nucleotide excision repair_Homo sapiens_hsa034201.87318078
19Pyrimidine metabolism_Homo sapiens_hsa002401.86699220
20Alzheimers disease_Homo sapiens_hsa050101.85607496
21Non-homologous end-joining_Homo sapiens_hsa034501.84981501
22Fanconi anemia pathway_Homo sapiens_hsa034601.79834830
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65226582
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57686795
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.49716187
26Selenocompound metabolism_Homo sapiens_hsa004501.47353861
27Purine metabolism_Homo sapiens_hsa002301.41721877
28Propanoate metabolism_Homo sapiens_hsa006401.41363903
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40427432
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39867387
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34763741
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33848975
33Vitamin digestion and absorption_Homo sapiens_hsa049771.29666014
34Cell cycle_Homo sapiens_hsa041101.25310713
35Cardiac muscle contraction_Homo sapiens_hsa042601.24510315
36Pyruvate metabolism_Homo sapiens_hsa006201.22997327
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15956192
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14348754
39Folate biosynthesis_Homo sapiens_hsa007901.13653116
40mRNA surveillance pathway_Homo sapiens_hsa030151.02075818
41Vitamin B6 metabolism_Homo sapiens_hsa007501.00549869
42Glutathione metabolism_Homo sapiens_hsa004801.00341104
43Fatty acid elongation_Homo sapiens_hsa000620.99559972
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94850702
45Sulfur relay system_Homo sapiens_hsa041220.94150706
46Steroid biosynthesis_Homo sapiens_hsa001000.89710670
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85610401
48Metabolic pathways_Homo sapiens_hsa011000.78529401
49Phototransduction_Homo sapiens_hsa047440.77903089
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70155053
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68518108
52Butanoate metabolism_Homo sapiens_hsa006500.66525046
53Nitrogen metabolism_Homo sapiens_hsa009100.62210952
54Biosynthesis of amino acids_Homo sapiens_hsa012300.61604737
55Peroxisome_Homo sapiens_hsa041460.61259798
56Oocyte meiosis_Homo sapiens_hsa041140.60931931
57Tryptophan metabolism_Homo sapiens_hsa003800.60725181
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58305630
59Caffeine metabolism_Homo sapiens_hsa002320.57990031
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57967693
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55646716
62Linoleic acid metabolism_Homo sapiens_hsa005910.52793599
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52458490
64Sulfur metabolism_Homo sapiens_hsa009200.51205335
65Carbon metabolism_Homo sapiens_hsa012000.48936822
66Chemical carcinogenesis_Homo sapiens_hsa052040.48428226
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48287591
68p53 signaling pathway_Homo sapiens_hsa041150.47680526
69beta-Alanine metabolism_Homo sapiens_hsa004100.45442625
70Retinol metabolism_Homo sapiens_hsa008300.44961018
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44764973
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43683276
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41410332
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39250036
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39023810
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38142191
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36156306
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35936917
79Arginine and proline metabolism_Homo sapiens_hsa003300.35249273
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34841107
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.34185932
82Fatty acid degradation_Homo sapiens_hsa000710.33420851
83Fatty acid metabolism_Homo sapiens_hsa012120.31519934
84Olfactory transduction_Homo sapiens_hsa047400.31077674
85Fat digestion and absorption_Homo sapiens_hsa049750.29432213
86Epstein-Barr virus infection_Homo sapiens_hsa051690.29256612
87Basal cell carcinoma_Homo sapiens_hsa052170.27417049
88Hedgehog signaling pathway_Homo sapiens_hsa043400.26369322
89Ether lipid metabolism_Homo sapiens_hsa005650.23960294
90Arachidonic acid metabolism_Homo sapiens_hsa005900.23479454
91N-Glycan biosynthesis_Homo sapiens_hsa005100.23140209
92Wnt signaling pathway_Homo sapiens_hsa043100.21807709
93Taste transduction_Homo sapiens_hsa047420.21112352
94TGF-beta signaling pathway_Homo sapiens_hsa043500.20819869
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.20444256
96Hippo signaling pathway_Homo sapiens_hsa043900.19439938
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18519191
98Nicotine addiction_Homo sapiens_hsa050330.17612537
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17334762
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17022156

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