ERVK3-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.04209113
2DNA deamination (GO:0045006)4.58441586
3protein complex biogenesis (GO:0070271)4.56722595
4mitochondrial respiratory chain complex assembly (GO:0033108)4.40334907
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.37634164
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.37634164
7NADH dehydrogenase complex assembly (GO:0010257)4.37634164
8ATP synthesis coupled proton transport (GO:0015986)4.32203541
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.32203541
10chaperone-mediated protein transport (GO:0072321)4.28199198
11proteasome assembly (GO:0043248)4.08716513
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06213545
13DNA double-strand break processing (GO:0000729)3.89561920
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.85678518
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.83351858
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.82458097
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82094479
18respiratory chain complex IV assembly (GO:0008535)3.76410985
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.71934257
20termination of RNA polymerase III transcription (GO:0006386)3.71934257
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68094268
22respiratory electron transport chain (GO:0022904)3.67210260
23rRNA modification (GO:0000154)3.64408649
24electron transport chain (GO:0022900)3.61128886
25peptidyl-histidine modification (GO:0018202)3.60824506
26regulation of cellular amino acid metabolic process (GO:0006521)3.59355769
27regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.56077423
28cytochrome complex assembly (GO:0017004)3.50949570
29organelle disassembly (GO:1903008)3.50331377
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48978714
31negative regulation of ligase activity (GO:0051352)3.48978714
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.47407524
33pseudouridine synthesis (GO:0001522)3.45887213
34ribonucleoprotein complex disassembly (GO:0032988)3.44916999
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37212942
36signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37212942
37signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37212942
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37115964
39signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37115964
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35384164
41DNA catabolic process, exonucleolytic (GO:0000738)3.31657608
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31573912
43protein targeting to mitochondrion (GO:0006626)3.31558837
44positive regulation of ligase activity (GO:0051351)3.23958207
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.23427670
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23299754
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.21907353
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21907353
49protein localization to mitochondrion (GO:0070585)3.15755041
50regulation of mitochondrial translation (GO:0070129)3.15220255
51spliceosomal snRNP assembly (GO:0000387)3.13759258
52protein neddylation (GO:0045116)3.12311256
53establishment of protein localization to mitochondrion (GO:0072655)3.08217068
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08004644
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08004644
56histone H2A acetylation (GO:0043968)3.07642385
57tRNA processing (GO:0008033)3.04546838
58ribosomal small subunit biogenesis (GO:0042274)3.02911677
59cullin deneddylation (GO:0010388)3.01305204
60protein deneddylation (GO:0000338)2.98617087
61metallo-sulfur cluster assembly (GO:0031163)2.95879357
62iron-sulfur cluster assembly (GO:0016226)2.95879357
63ribosomal large subunit biogenesis (GO:0042273)2.94237148
64protein-cofactor linkage (GO:0018065)2.93191532
65rRNA methylation (GO:0031167)2.92009812
66cellular component biogenesis (GO:0044085)2.91670271
67postreplication repair (GO:0006301)2.91376131
68activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.89804725
69regulation of ubiquitin-protein transferase activity (GO:0051438)2.89679289
70translation (GO:0006412)2.88146973
71positive regulation of granulocyte differentiation (GO:0030854)2.86099525
72rRNA processing (GO:0006364)2.83413669
73regulation of ligase activity (GO:0051340)2.82097628
74positive regulation of protein homodimerization activity (GO:0090073)2.81941018
75ribosome assembly (GO:0042255)2.79498203
76rRNA metabolic process (GO:0016072)2.74966494
77mannosylation (GO:0097502)2.74101578
78ribosomal small subunit assembly (GO:0000028)2.73349809
79mitochondrial RNA metabolic process (GO:0000959)2.71942165
80histone mRNA metabolic process (GO:0008334)2.71825583
81telomere maintenance via semi-conservative replication (GO:0032201)2.71660913
82L-methionine biosynthetic process (GO:0071265)2.69906881
83amino acid salvage (GO:0043102)2.69906881
84L-methionine salvage (GO:0071267)2.69906881
85DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.68129531
86tRNA metabolic process (GO:0006399)2.67084320
87negative regulation of protein ubiquitination (GO:0031397)2.63838634
88positive regulation of cell cycle arrest (GO:0071158)2.63138861
89ncRNA processing (GO:0034470)2.62693636
90kinetochore assembly (GO:0051382)2.62347947
91transcription-coupled nucleotide-excision repair (GO:0006283)2.61221838
92hydrogen ion transmembrane transport (GO:1902600)2.61037241
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60770455
94DNA damage response, detection of DNA damage (GO:0042769)2.60769533
95regulation of cellular amine metabolic process (GO:0033238)2.60380564
96maturation of SSU-rRNA (GO:0030490)2.59847984
97translational termination (GO:0006415)2.59473370
98regulation of helicase activity (GO:0051095)2.59465279
99deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.57091386
100DNA strand elongation involved in DNA replication (GO:0006271)2.56086916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.04883129
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.97427316
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.43679551
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.27510181
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.07717979
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86062869
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.65588988
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.35257995
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.31112137
10VDR_23849224_ChIP-Seq_CD4+_Human3.22156422
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94827996
12FOXP3_21729870_ChIP-Seq_TREG_Human2.74155953
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72133833
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61772026
15ELK1_19687146_ChIP-ChIP_HELA_Human2.57079546
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.51874865
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.47922646
18ZNF274_21170338_ChIP-Seq_K562_Hela2.43360029
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35176099
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33253739
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.31775261
22E2F7_22180533_ChIP-Seq_HELA_Human2.27287181
23DCP1A_22483619_ChIP-Seq_HELA_Human2.24040522
24GABP_19822575_ChIP-Seq_HepG2_Human2.21973862
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21365560
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17901689
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15526028
28VDR_22108803_ChIP-Seq_LS180_Human2.08470139
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07933025
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06123797
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05802242
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.98956814
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98313065
34CIITA_25753668_ChIP-Seq_RAJI_Human1.97797814
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92640709
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87074597
37XRN2_22483619_ChIP-Seq_HELA_Human1.85567939
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.83182177
39TTF2_22483619_ChIP-Seq_HELA_Human1.79657674
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72713224
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72031774
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71020923
43MYC_18940864_ChIP-ChIP_HL60_Human1.68988775
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65260695
45IGF1R_20145208_ChIP-Seq_DFB_Human1.63474655
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60859028
47KDM5A_27292631_Chip-Seq_BREAST_Human1.60082180
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58039767
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56833365
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54007159
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.53600400
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49252434
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36941189
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36817840
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35057757
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34690706
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33580618
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33319329
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30512704
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.30019729
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24396570
62IRF1_19129219_ChIP-ChIP_H3396_Human1.22878711
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20731083
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17875643
65EWS_26573619_Chip-Seq_HEK293_Human1.16842974
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16332406
67FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15654810
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10873334
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.06620535
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04502698
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98693270
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98097511
73TP63_19390658_ChIP-ChIP_HaCaT_Human0.97330173
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94023599
75TP53_22573176_ChIP-Seq_HFKS_Human0.93169720
76TFEB_21752829_ChIP-Seq_HELA_Human0.93130559
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92632709
78GATA3_26560356_Chip-Seq_TH2_Human0.90428031
79MYB_26560356_Chip-Seq_TH2_Human0.89611167
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89381710
81ER_23166858_ChIP-Seq_MCF-7_Human0.87630302
82FUS_26573619_Chip-Seq_HEK293_Human0.87119315
83SPI1_23547873_ChIP-Seq_NB4_Human0.86218946
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84732785
85ELF5_23300383_ChIP-Seq_T47D_Human0.82509066
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78952386
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76222999
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75005341
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74322801
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72780777
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72628483
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71132805
93NCOR_22424771_ChIP-Seq_293T_Human0.67615330
94CTBP1_25329375_ChIP-Seq_LNCAP_Human0.67190640
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.66928411
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.66664015
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.65331770
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.65284725
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.64836021
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.64767556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.34808450
2MP0010094_abnormal_chromosome_stability2.84288446
3MP0002102_abnormal_ear_morphology2.75883570
4MP0003786_premature_aging2.73065649
5MP0008057_abnormal_DNA_replication2.69284064
6MP0003693_abnormal_embryo_hatching2.57207266
7MP0008995_early_reproductive_senescence2.47268848
8MP0003806_abnormal_nucleotide_metabolis2.36171153
9MP0003763_abnormal_thymus_physiology2.27674373
10MP0006036_abnormal_mitochondrial_physio2.25711342
11MP0008877_abnormal_DNA_methylation2.14933487
12MP0006035_abnormal_mitochondrial_morpho1.97969571
13MP0003077_abnormal_cell_cycle1.90028584
14MP0003186_abnormal_redox_activity1.88749102
15MP0000372_irregular_coat_pigmentation1.87339948
16MP0001873_stomach_inflammation1.87171392
17MP0003111_abnormal_nucleus_morphology1.86244828
18MP0001986_abnormal_taste_sensitivity1.80765706
19MP0005671_abnormal_response_to1.71148151
20MP0001529_abnormal_vocalization1.69674182
21MP0008789_abnormal_olfactory_epithelium1.68085590
22MP0008007_abnormal_cellular_replicative1.65812443
23MP0004957_abnormal_blastocyst_morpholog1.62524103
24MP0003950_abnormal_plasma_membrane1.60172326
25MP0002132_abnormal_respiratory_system1.55657760
26MP0005499_abnormal_olfactory_system1.48405019
27MP0005394_taste/olfaction_phenotype1.48405019
28MP0002277_abnormal_respiratory_mucosa1.47767740
29MP0006292_abnormal_olfactory_placode1.46680043
30MP0003718_maternal_effect1.43533511
31MP0001764_abnormal_homeostasis1.43231726
32MP0006072_abnormal_retinal_apoptosis1.43191222
33MP0002837_dystrophic_cardiac_calcinosis1.38979076
34MP0009333_abnormal_splenocyte_physiolog1.38814282
35MP0002736_abnormal_nociception_after1.35603296
36MP0001853_heart_inflammation1.34797771
37MP0008872_abnormal_physiological_respon1.34669188
38MP0005075_abnormal_melanosome_morpholog1.31965954
39MP0003787_abnormal_imprinting1.28718733
40MP0004142_abnormal_muscle_tone1.28160954
41MP0000703_abnormal_thymus_morphology1.27622580
42MP0001919_abnormal_reproductive_system1.27206113
43MP0001905_abnormal_dopamine_level1.24144031
44MP0008875_abnormal_xenobiotic_pharmacok1.23839906
45MP0001800_abnormal_humoral_immune1.20364948
46MP0001968_abnormal_touch/_nociception1.15595853
47MP0002095_abnormal_skin_pigmentation1.14294757
48MP0009785_altered_susceptibility_to1.14207099
49MP0005084_abnormal_gallbladder_morpholo1.10884838
50MP0008932_abnormal_embryonic_tissue1.09822535
51MP0001984_abnormal_olfaction1.09020619
52MP0000749_muscle_degeneration1.08816904
53MP0001929_abnormal_gametogenesis1.08361685
54MP0002210_abnormal_sex_determination1.05977182
55MP0002638_abnormal_pupillary_reflex1.05861509
56MP0002160_abnormal_reproductive_system1.04223648
57MP0002163_abnormal_gland_morphology1.04141658
58MP0005389_reproductive_system_phenotype1.03825804
59MP0001835_abnormal_antigen_presentation1.03627413
60MP0005253_abnormal_eye_physiology1.03624851
61MP0003880_abnormal_central_pattern0.98544935
62MP0006276_abnormal_autonomic_nervous0.97018785
63MP0002398_abnormal_bone_marrow0.95154795
64MP0002723_abnormal_immune_serum0.93095133
65MP0002722_abnormal_immune_system0.92473400
66MP0000358_abnormal_cell_content/0.92381935
67MP0000313_abnormal_cell_death0.92129493
68MP0003121_genomic_imprinting0.91635119
69MP0008961_abnormal_basal_metabolism0.91613666
70MP0002420_abnormal_adaptive_immunity0.91508093
71MP0000015_abnormal_ear_pigmentation0.90357043
72MP0005266_abnormal_metabolism0.90163765
73MP0000689_abnormal_spleen_morphology0.90088835
74MP0005645_abnormal_hypothalamus_physiol0.88382091
75MP0001819_abnormal_immune_cell0.86693402
76MP0009046_muscle_twitch0.86215146
77MP0005646_abnormal_pituitary_gland0.85672322
78MP0003315_abnormal_perineum_morphology0.85447214
79MP0005310_abnormal_salivary_gland0.85174752
80MP0009697_abnormal_copulation0.84594646
81MP0000716_abnormal_immune_system0.83928552
82MP0005000_abnormal_immune_tolerance0.82858996
83MP0002019_abnormal_tumor_incidence0.82811371
84MP0005551_abnormal_eye_electrophysiolog0.80239330
85MP0002653_abnormal_ependyma_morphology0.79652477
86MP0001188_hyperpigmentation0.79473748
87MP0003698_abnormal_male_reproductive0.79181269
88MP0003221_abnormal_cardiomyocyte_apopto0.77533479
89MP0002693_abnormal_pancreas_physiology0.76785863
90MP0004742_abnormal_vestibular_system0.75574879
91MP0002452_abnormal_antigen_presenting0.75448576
92MP0001145_abnormal_male_reproductive0.75053607
93MP0004381_abnormal_hair_follicle0.74462355
94MP0000653_abnormal_sex_gland0.73823094
95MP0002822_catalepsy0.73446812
96MP0005410_abnormal_fertilization0.72855666
97MP0001790_abnormal_immune_system0.72853439
98MP0005387_immune_system_phenotype0.72853439
99MP0005174_abnormal_tail_pigmentation0.71559040
100MP0002429_abnormal_blood_cell0.71376965

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.51729116
2Mitochondrial inheritance (HP:0001427)4.33441390
3Abnormal mitochondria in muscle tissue (HP:0008316)4.23991414
4Hepatocellular necrosis (HP:0001404)4.02635233
5Increased CSF lactate (HP:0002490)3.96949838
6Progressive macrocephaly (HP:0004481)3.89613186
7Acute encephalopathy (HP:0006846)3.77531362
8Hepatic necrosis (HP:0002605)3.63454268
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34900690
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34900690
113-Methylglutaconic aciduria (HP:0003535)3.25718236
12Increased hepatocellular lipid droplets (HP:0006565)3.22213893
13Lipid accumulation in hepatocytes (HP:0006561)3.19232311
14Aplastic anemia (HP:0001915)3.10887852
15Increased serum lactate (HP:0002151)3.02448690
16Cerebral edema (HP:0002181)2.82711886
17Lactic acidosis (HP:0003128)2.74898432
18Renal Fanconi syndrome (HP:0001994)2.71586780
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63739429
20Microvesicular hepatic steatosis (HP:0001414)2.61132987
21Increased intramyocellular lipid droplets (HP:0012240)2.60136137
22Methylmalonic acidemia (HP:0002912)2.59944458
23Abnormal number of erythroid precursors (HP:0012131)2.57498442
24Methylmalonic aciduria (HP:0012120)2.50134771
25Pancreatic cysts (HP:0001737)2.47183825
26Hypoplasia of the thymus (HP:0000778)2.44872002
27Abnormal protein glycosylation (HP:0012346)2.42279254
28Abnormal glycosylation (HP:0012345)2.42279254
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42279254
30Abnormal protein N-linked glycosylation (HP:0012347)2.42279254
31Pancytopenia (HP:0001876)2.42056713
32Renal cortical cysts (HP:0000803)2.38934913
33Type I transferrin isoform profile (HP:0003642)2.37407544
34Abnormality of cells of the erythroid lineage (HP:0012130)2.35958765
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31499917
36Cerebral hypomyelination (HP:0006808)2.29071518
37Increased muscle lipid content (HP:0009058)2.28402673
38Medial flaring of the eyebrow (HP:0010747)2.25904559
39Exercise intolerance (HP:0003546)2.25718360
40Respiratory failure (HP:0002878)2.24703717
41Reduced antithrombin III activity (HP:0001976)2.19404333
42IgG deficiency (HP:0004315)2.17388191
43Lethargy (HP:0001254)2.17220312
44Optic disc pallor (HP:0000543)2.16844392
45Progressive microcephaly (HP:0000253)2.14218802
46Panhypogammaglobulinemia (HP:0003139)2.13789573
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11770513
48Abnormality of alanine metabolism (HP:0010916)2.11770513
49Hyperalaninemia (HP:0003348)2.11770513
50Hypothermia (HP:0002045)2.11312900
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10845725
52CNS demyelination (HP:0007305)2.09646974
53Aplasia/hypoplasia of the uterus (HP:0008684)2.09305144
54Severe combined immunodeficiency (HP:0004430)2.06851545
55Meckel diverticulum (HP:0002245)2.04718402
56Absent thumb (HP:0009777)2.03861507
57Abnormality of midbrain morphology (HP:0002418)2.02000382
58Molar tooth sign on MRI (HP:0002419)2.02000382
59Abnormality of the ileum (HP:0001549)2.01501716
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.00511940
61Leukodystrophy (HP:0002415)2.00498751
62Increased serum pyruvate (HP:0003542)1.96333078
63Respiratory difficulties (HP:0002880)1.96111749
64Abnormality of the pons (HP:0007361)1.95695994
65Exertional dyspnea (HP:0002875)1.93228084
66Pancreatic fibrosis (HP:0100732)1.92686973
67Emotional lability (HP:0000712)1.91984002
68Abnormality of the preputium (HP:0100587)1.91762781
69Abnormality of the labia minora (HP:0012880)1.90138604
70Hypoplasia of the pons (HP:0012110)1.88685420
71Colon cancer (HP:0003003)1.87525240
72Nephrogenic diabetes insipidus (HP:0009806)1.87426500
73Abnormality of chromosome stability (HP:0003220)1.86348026
74Carpal bone hypoplasia (HP:0001498)1.84720774
75Calf muscle hypertrophy (HP:0008981)1.84483485
76Congenital primary aphakia (HP:0007707)1.83761524
77Generalized aminoaciduria (HP:0002909)1.83757320
78Reticulocytopenia (HP:0001896)1.82632021
79Eosinophilia (HP:0001880)1.82558111
80Type 2 muscle fiber atrophy (HP:0003554)1.82033561
81True hermaphroditism (HP:0010459)1.81525348
82Macrocytic anemia (HP:0001972)1.81143607
83Gait imbalance (HP:0002141)1.79665046
84Poor suck (HP:0002033)1.76252891
85Elevated erythrocyte sedimentation rate (HP:0003565)1.75918549
86Degeneration of anterior horn cells (HP:0002398)1.72230670
87Abnormality of the anterior horn cell (HP:0006802)1.72230670
88Abnormality of renal resorption (HP:0011038)1.72151470
89Sensory axonal neuropathy (HP:0003390)1.68555116
90Myelodysplasia (HP:0002863)1.68077103
91Abnormal rod and cone electroretinograms (HP:0008323)1.67477380
92CNS hypomyelination (HP:0003429)1.67007911
93Abnormality of eosinophils (HP:0001879)1.66121052
94Congenital stationary night blindness (HP:0007642)1.65889858
95Abnormality of the renal cortex (HP:0011035)1.65652240
96Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65236846
97Dicarboxylic aciduria (HP:0003215)1.65236846
98Premature ovarian failure (HP:0008209)1.64840665
99Squamous cell carcinoma (HP:0002860)1.64382587
100Thyroiditis (HP:0100646)1.62488982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.63554026
2VRK23.30203643
3SRPK13.10433450
4FRK2.70817761
5STK162.51306335
6TXK2.43596308
7CDC72.34455416
8TRIM282.30010866
9NME12.28045053
10EIF2AK32.26538513
11VRK12.25057404
12ZAK2.24457824
13MAP4K21.88547308
14TESK21.87865418
15NUAK11.80374568
16MARK31.79634595
17PDK21.78666938
18MAP2K71.75917026
19PINK11.71490540
20CCNB11.64960043
21CSNK1G31.55896070
22CSNK1A1L1.51654468
23BMPR1B1.49574245
24NME21.46360430
25MAPKAPK51.41475735
26CDK81.36924624
27TLK11.31220828
28WNK31.29922534
29STK38L1.29712706
30EIF2AK11.28944945
31CSNK1G11.26441863
32ADRBK21.26412830
33BCKDK1.25042234
34MAPK131.17218247
35BRSK21.17105524
36MAP4K11.14330982
37MAP3K41.13267657
38DYRK31.12643035
39CSNK1G21.11131683
40ATR1.09111341
41MUSK1.06175033
42RPS6KA41.05470485
43DYRK21.03112992
44PLK31.02569002
45PLK40.99222279
46NEK10.97964382
47MST40.96683026
48RPS6KA50.94787996
49TEC0.94509549
50GRK10.92760370
51IKBKB0.90867536
52MKNK20.89068010
53PLK10.86157236
54DAPK10.83742952
55TSSK60.83452519
56PBK0.78213545
57CAMKK20.76255394
58ITK0.75032844
59CDK30.74535087
60IKBKE0.71576756
61TAOK30.69344301
62TNK20.67825231
63SIK30.66842432
64NEK20.65796617
65CLK10.65273888
66AURKB0.65206036
67BCR0.64662346
68PIM20.63808991
69CSNK2A10.63411803
70ERBB30.61842608
71MAPKAPK30.59093424
72CSNK2A20.58684117
73ATM0.57299825
74BRSK10.56651722
75TAF10.56276198
76BTK0.55366772
77KDR0.54410085
78CHEK20.53793860
79AURKA0.50404494
80BLK0.50128923
81MAP3K120.50113923
82SYK0.48818028
83AKT30.48237191
84PASK0.47512804
85GRK60.47024838
86CDK40.46176225
87PIK3CG0.44396567
88BMPR20.44116147
89CSNK1A10.42690528
90CDK190.42636491
91PRKCQ0.42081370
92CHEK10.42075822
93MKNK10.40308913
94LYN0.40091128
95STK40.38322958
96LCK0.38090042
97BRD40.37563174
98WEE10.35785286
99INSRR0.34440853
100CSNK1D0.33770554

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.68282602
2Oxidative phosphorylation_Homo sapiens_hsa001903.78067210
3RNA polymerase_Homo sapiens_hsa030203.60671422
4Ribosome_Homo sapiens_hsa030103.39267235
5Parkinsons disease_Homo sapiens_hsa050123.26968532
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93243718
7DNA replication_Homo sapiens_hsa030302.85810947
8Protein export_Homo sapiens_hsa030602.74736373
9Homologous recombination_Homo sapiens_hsa034402.72615439
10Mismatch repair_Homo sapiens_hsa034302.70814993
11Spliceosome_Homo sapiens_hsa030402.47041374
12Fanconi anemia pathway_Homo sapiens_hsa034602.37737482
13Huntingtons disease_Homo sapiens_hsa050162.26500342
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06450287
15Alzheimers disease_Homo sapiens_hsa050102.02483997
16Pyrimidine metabolism_Homo sapiens_hsa002401.92645028
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82957922
18RNA degradation_Homo sapiens_hsa030181.82634808
19Nucleotide excision repair_Homo sapiens_hsa034201.80455893
20Base excision repair_Homo sapiens_hsa034101.78789988
21Basal transcription factors_Homo sapiens_hsa030221.73810859
22Non-homologous end-joining_Homo sapiens_hsa034501.63774242
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61374920
24RNA transport_Homo sapiens_hsa030131.59534750
25Primary immunodeficiency_Homo sapiens_hsa053401.56465068
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44427160
27Regulation of autophagy_Homo sapiens_hsa041401.35379575
28Purine metabolism_Homo sapiens_hsa002301.32071165
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30987050
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12679805
31Sulfur relay system_Homo sapiens_hsa041221.11710244
32One carbon pool by folate_Homo sapiens_hsa006701.09000861
33Cardiac muscle contraction_Homo sapiens_hsa042601.06573532
34Propanoate metabolism_Homo sapiens_hsa006401.05368280
35Collecting duct acid secretion_Homo sapiens_hsa049661.04283418
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02923042
37Butanoate metabolism_Homo sapiens_hsa006500.97505811
38Fatty acid elongation_Homo sapiens_hsa000620.92443484
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.92142712
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92019077
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90210320
42Peroxisome_Homo sapiens_hsa041460.86814385
43Phototransduction_Homo sapiens_hsa047440.84947011
44Selenocompound metabolism_Homo sapiens_hsa004500.84550209
45Cell cycle_Homo sapiens_hsa041100.82759695
46mRNA surveillance pathway_Homo sapiens_hsa030150.80075808
47Folate biosynthesis_Homo sapiens_hsa007900.79580005
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77709212
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76788305
50Epstein-Barr virus infection_Homo sapiens_hsa051690.71453800
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66321408
52Metabolic pathways_Homo sapiens_hsa011000.65695995
53Pyruvate metabolism_Homo sapiens_hsa006200.63653975
54Glutathione metabolism_Homo sapiens_hsa004800.60509763
55Circadian rhythm_Homo sapiens_hsa047100.60390656
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56145853
57beta-Alanine metabolism_Homo sapiens_hsa004100.55812809
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.54634038
59Autoimmune thyroid disease_Homo sapiens_hsa053200.54619108
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53269819
61Allograft rejection_Homo sapiens_hsa053300.52034888
62p53 signaling pathway_Homo sapiens_hsa041150.49737288
63T cell receptor signaling pathway_Homo sapiens_hsa046600.49487556
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47927043
65Systemic lupus erythematosus_Homo sapiens_hsa053220.47369572
66Oocyte meiosis_Homo sapiens_hsa041140.46556589
67Type I diabetes mellitus_Homo sapiens_hsa049400.45986092
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.45769959
69Tryptophan metabolism_Homo sapiens_hsa003800.45757670
70Olfactory transduction_Homo sapiens_hsa047400.45426933
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41331680
72Steroid biosynthesis_Homo sapiens_hsa001000.41009786
73Rheumatoid arthritis_Homo sapiens_hsa053230.40253750
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.39356176
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38283645
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37912119
77Graft-versus-host disease_Homo sapiens_hsa053320.37907884
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37630876
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37611501
80Asthma_Homo sapiens_hsa053100.37229013
81Chemical carcinogenesis_Homo sapiens_hsa052040.36404320
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36146951
83Measles_Homo sapiens_hsa051620.33276176
84Herpes simplex infection_Homo sapiens_hsa051680.32966359
85Nitrogen metabolism_Homo sapiens_hsa009100.32442804
86Caffeine metabolism_Homo sapiens_hsa002320.31837073
87Legionellosis_Homo sapiens_hsa051340.30070917
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29510037
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29306807
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.28625922
91Alcoholism_Homo sapiens_hsa050340.28210608
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27243622
93Taste transduction_Homo sapiens_hsa047420.24790371
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24113466
95N-Glycan biosynthesis_Homo sapiens_hsa005100.23877765
96Antigen processing and presentation_Homo sapiens_hsa046120.23397533
97Nicotine addiction_Homo sapiens_hsa050330.22973421
98Apoptosis_Homo sapiens_hsa042100.22182777
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.22062345
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21713860

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