ERVFRD-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)7.23134125
2regulation of sister chromatid cohesion (GO:0007063)5.56673575
3opioid receptor signaling pathway (GO:0038003)5.55410110
4mesenchymal-epithelial cell signaling (GO:0060638)5.52736076
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.44463382
6positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.36429430
7regulation of tumor necrosis factor biosynthetic process (GO:0042534)5.29667504
8GDP-mannose metabolic process (GO:0019673)5.25433604
9diterpenoid biosynthetic process (GO:0016102)5.22386743
10phosphatidylethanolamine biosynthetic process (GO:0006646)5.20429607
11regulation of mitochondrial translation (GO:0070129)5.18773542
12regulation of MHC class II biosynthetic process (GO:0045346)5.13697909
13microglial cell activation (GO:0001774)5.13606572
14regulation of centriole replication (GO:0046599)4.95855965
15phosphatidylcholine biosynthetic process (GO:0006656)4.92237550
16arginine catabolic process (GO:0006527)4.91698859
17positive regulation of chemokine biosynthetic process (GO:0045080)4.83898802
18carnitine shuttle (GO:0006853)4.83019818
19phosphatidylethanolamine metabolic process (GO:0046337)4.82036747
20positive regulation of histone H3-K4 methylation (GO:0051571)4.80579842
21regulation of chemokine biosynthetic process (GO:0045073)4.78756508
22pyrimidine nucleotide catabolic process (GO:0006244)4.69225685
23cell wall macromolecule catabolic process (GO:0016998)4.66273124
24dosage compensation (GO:0007549)4.62285072
25response to hepatocyte growth factor (GO:0035728)4.55612575
26cellular response to hepatocyte growth factor stimulus (GO:0035729)4.55612575
27DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.50979537
28regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.48713567
29protein K6-linked ubiquitination (GO:0085020)4.48657359
30induction of positive chemotaxis (GO:0050930)4.44813983
31negative regulation of fatty acid biosynthetic process (GO:0045717)4.26106363
32mitotic sister chromatid cohesion (GO:0007064)4.21876593
33positive regulation of extracellular matrix organization (GO:1903055)4.05029113
34galactose catabolic process (GO:0019388)4.04472477
35negative regulation of histone acetylation (GO:0035067)4.01277880
36DNA damage response, signal transduction resulting in transcription (GO:0042772)3.99364456
37respiratory chain complex IV assembly (GO:0008535)3.98051821
38carnitine transmembrane transport (GO:1902603)3.84577910
39positive regulation of DNA biosynthetic process (GO:2000573)3.81793967
40fatty acid transmembrane transport (GO:1902001)3.80050179
41cell wall macromolecule metabolic process (GO:0044036)3.79018226
42negative regulation of peptidyl-lysine acetylation (GO:2000757)3.78518127
43terpenoid biosynthetic process (GO:0016114)3.78480651
44amino-acid betaine transport (GO:0015838)3.77148661
45carnitine transport (GO:0015879)3.77148661
46protein retention in ER lumen (GO:0006621)3.68671355
47negative regulation of protein acetylation (GO:1901984)3.60676227
48GMP metabolic process (GO:0046037)3.60551251
49monoubiquitinated protein deubiquitination (GO:0035520)3.58704104
50peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.56182846
51pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.55245591
52kinetochore assembly (GO:0051382)3.50447565
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42975431
54negative regulation of cell aging (GO:0090344)3.42203709
55cytochrome complex assembly (GO:0017004)3.38124674
56negative regulation of T cell receptor signaling pathway (GO:0050860)3.38107801
57negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.37872169
58snRNA processing (GO:0016180)3.37313223
59snRNA metabolic process (GO:0016073)3.35652974
60female gonad development (GO:0008585)3.35571540
61platelet dense granule organization (GO:0060155)3.29851894
62peptidyl-lysine dimethylation (GO:0018027)3.28922214
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26312441
64double-strand break repair via nonhomologous end joining (GO:0006303)3.24192421
65non-recombinational repair (GO:0000726)3.24192421
66muscle organ morphogenesis (GO:0048644)3.23855495
67regulation of histone H3-K9 methylation (GO:0051570)3.21915386
68negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)3.17512387
69pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.17146221
70negative regulation of growth of symbiont in host (GO:0044130)3.17091591
71negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.17091591
72modulation of growth of symbiont involved in interaction with host (GO:0044144)3.17091591
73regulation of growth of symbiont in host (GO:0044126)3.17091591
74regulation of gene expression by genetic imprinting (GO:0006349)3.15238020
75positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.13174923
76protein targeting to peroxisome (GO:0006625)3.10641078
77establishment of protein localization to peroxisome (GO:0072663)3.10641078
78protein localization to peroxisome (GO:0072662)3.10641078
79kinetochore organization (GO:0051383)3.09044754
80nucleotide-sugar biosynthetic process (GO:0009226)3.08431649
81negative regulation of response to reactive oxygen species (GO:1901032)3.08245002
82positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.07639333
83meiotic chromosome segregation (GO:0045132)3.04043584
84hydrogen peroxide catabolic process (GO:0042744)3.00946955
85glial cell migration (GO:0008347)3.00084213
86neutrophil mediated immunity (GO:0002446)2.98416688
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.97972708
88phagocytosis, engulfment (GO:0006911)2.96340618
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.95393846
90L-phenylalanine metabolic process (GO:0006558)2.95393846
91DNA replication-dependent nucleosome assembly (GO:0006335)2.93928635
92DNA replication-dependent nucleosome organization (GO:0034723)2.93928635
93macrophage chemotaxis (GO:0048246)2.89551754
94negative regulation of organelle assembly (GO:1902116)2.88695158
95positive regulation of interleukin-1 beta production (GO:0032731)2.88534717
96galactose metabolic process (GO:0006012)2.87868428
97viral entry into host cell (GO:0046718)2.83367596
98outer ear morphogenesis (GO:0042473)2.82040880
99secretory granule organization (GO:0033363)2.81995187
100regulation of hydrogen peroxide-induced cell death (GO:1903205)2.81147106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.22224869
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.62918136
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.21140929
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.06372800
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00011318
6KDM5A_27292631_Chip-Seq_BREAST_Human2.41112702
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.24076805
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.21395603
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17151856
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15432334
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.14877204
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12511522
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10127797
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.07108861
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06124502
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.03986790
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.03429991
18E2F7_22180533_ChIP-Seq_HELA_Human10.6450085
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99002182
20GABP_19822575_ChIP-Seq_HepG2_Human1.97718544
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90951666
22ELK1_19687146_ChIP-ChIP_HELA_Human1.85908456
23VDR_21846776_ChIP-Seq_THP-1_Human1.78427618
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.70343920
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66942578
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62999305
27VDR_23849224_ChIP-Seq_CD4+_Human1.52232331
28MYC_18940864_ChIP-ChIP_HL60_Human1.50803590
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.47923269
30BRD4_25478319_ChIP-Seq_HGPS_Human1.47151404
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46888488
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.46355851
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42729927
34VDR_24763502_ChIP-Seq_THP-1_Human1.40976955
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40071134
36FOXP3_21729870_ChIP-Seq_TREG_Human1.33650797
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32921273
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.32856722
39SCL_19346495_ChIP-Seq_HPC-7_Human1.30711433
40MYB_26560356_Chip-Seq_TH1_Human1.29381466
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28933833
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.27475416
43TAF15_26573619_Chip-Seq_HEK293_Human1.24735935
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23612782
45TFEB_21752829_ChIP-Seq_HELA_Human1.21385214
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17145087
47EWS_26573619_Chip-Seq_HEK293_Human1.16132226
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15370205
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12368870
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11011326
51DCP1A_22483619_ChIP-Seq_HELA_Human1.10104243
52AR_21909140_ChIP-Seq_LNCAP_Human1.09656877
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08864055
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08646318
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.08526393
56CEBPB_22108803_ChIP-Seq_LS180_Human1.07311253
57CBP_20019798_ChIP-Seq_JUKART_Human1.06472306
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06472306
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04846922
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04754368
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04273445
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03477380
63BCAT_22108803_ChIP-Seq_LS180_Human1.03273870
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02890837
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02592365
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02102262
67MAF_26560356_Chip-Seq_TH2_Human1.01816899
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01609640
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00284337
70EST1_17652178_ChIP-ChIP_JURKAT_Human0.97839898
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96670467
72PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96669569
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95632912
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95080500
75SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94484463
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94463419
77UTX_26944678_Chip-Seq_JUKART_Human0.94292230
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94009465
79IRF8_22096565_ChIP-ChIP_GC-B_Human0.93544655
80SPI1_23547873_ChIP-Seq_NB4_Human0.92641901
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92018603
82WT1_19549856_ChIP-ChIP_CCG9911_Human0.90321602
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87625926
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86284482
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85967305
86FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85368924
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85038657
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84751210
89GATA3_21867929_ChIP-Seq_TH1_Mouse0.82696164
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82119612
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.80462834
92EGR1_23403033_ChIP-Seq_LIVER_Mouse0.80157709
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.80100932
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79827054
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79044620
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.78053919
97E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77456087
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.77358141
99MYC_19829295_ChIP-Seq_ESCs_Human0.77133213
100CDX2_22108803_ChIP-Seq_LS180_Human0.76005806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.84600826
2MP0010094_abnormal_chromosome_stability4.09752190
3MP0000015_abnormal_ear_pigmentation3.80080372
4MP0003705_abnormal_hypodermis_morpholog3.56113041
5MP0005174_abnormal_tail_pigmentation3.19046016
6MP0003950_abnormal_plasma_membrane3.01753688
7MP0004381_abnormal_hair_follicle2.80601076
8MP0009278_abnormal_bone_marrow2.76517159
9MP0003786_premature_aging2.65116242
10MP0003111_abnormal_nucleus_morphology2.48460067
11MP0005058_abnormal_lysosome_morphology2.48094929
12MP0008057_abnormal_DNA_replication2.41266791
13MP0002139_abnormal_hepatobiliary_system2.31175093
14MP0006072_abnormal_retinal_apoptosis2.23538244
15MP0005332_abnormal_amino_acid2.20325470
16MP0000427_abnormal_hair_cycle2.07118739
17MP0005075_abnormal_melanosome_morpholog2.06990582
18MP0002837_dystrophic_cardiac_calcinosis2.01959637
19MP0003172_abnormal_lysosome_physiology1.97443020
20MP0008058_abnormal_DNA_repair1.95001061
21MP0003890_abnormal_embryonic-extraembry1.91775908
22MP0000371_diluted_coat_color1.86591684
23MP0001661_extended_life_span1.86001094
24MP0008438_abnormal_cutaneous_collagen1.85126128
25MP0008007_abnormal_cellular_replicative1.84447531
26MP0005360_urolithiasis1.78492250
27MP0002095_abnormal_skin_pigmentation1.74917854
28MP0002166_altered_tumor_susceptibility1.71847278
29MP0005397_hematopoietic_system_phenotyp1.64109949
30MP0001545_abnormal_hematopoietic_system1.64109949
31MP0001968_abnormal_touch/_nociception1.59967391
32MP0002006_tumorigenesis1.55810776
33MP0001835_abnormal_antigen_presentation1.53918211
34MP0003656_abnormal_erythrocyte_physiolo1.49786448
35MP0008932_abnormal_embryonic_tissue1.47970455
36MP0010307_abnormal_tumor_latency1.46394471
37MP0003566_abnormal_cell_adhesion1.42821462
38MP0005084_abnormal_gallbladder_morpholo1.41435987
39MP0001243_abnormal_dermal_layer1.38310721
40MP0000470_abnormal_stomach_morphology1.37498102
41MP0000767_abnormal_smooth_muscle1.37167265
42MP0003077_abnormal_cell_cycle1.36743752
43MP0002269_muscular_atrophy1.36717603
44MP0004185_abnormal_adipocyte_glucose1.35875236
45MP0000749_muscle_degeneration1.30813311
46MP0002332_abnormal_exercise_endurance1.30648080
47MP0004134_abnormal_chest_morphology1.28882338
48MP0005023_abnormal_wound_healing1.27623994
49MP0001299_abnormal_eye_distance/1.25550663
50MP0005408_hypopigmentation1.23470753
51MP0000003_abnormal_adipose_tissue1.21871788
52MP0002735_abnormal_chemical_nociception1.21742009
53MP0001905_abnormal_dopamine_level1.18476023
54MP0009780_abnormal_chondrocyte_physiolo1.17279262
55MP0002876_abnormal_thyroid_physiology1.16874714
56MP0000538_abnormal_urinary_bladder1.16101273
57MP0010386_abnormal_urinary_bladder1.13343247
58MP0002163_abnormal_gland_morphology1.11560040
59MP0008961_abnormal_basal_metabolism1.10465321
60MP0005266_abnormal_metabolism1.08609910
61MP0002971_abnormal_brown_adipose1.04506580
62MP0001756_abnormal_urination1.03096567
63MP0002396_abnormal_hematopoietic_system1.01039958
64MP0010368_abnormal_lymphatic_system1.01011743
65MP0005164_abnormal_response_to1.00319549
66MP0005253_abnormal_eye_physiology0.99006150
67MP0003943_abnormal_hepatobiliary_system0.98227818
68MP0005379_endocrine/exocrine_gland_phen0.92451989
69MP0009697_abnormal_copulation0.92089615
70MP0001958_emphysema0.91384958
71MP0003632_abnormal_nervous_system0.89562524
72MP0000358_abnormal_cell_content/0.88278100
73MP0002111_abnormal_tail_morphology0.87763845
74MP0004808_abnormal_hematopoietic_stem0.86342808
75MP0002177_abnormal_outer_ear0.85496427
76MP0002075_abnormal_coat/hair_pigmentati0.81261111
77MP0003279_aneurysm0.81248806
78MP0005376_homeostasis/metabolism_phenot0.80306913
79MP0008770_decreased_survivor_rate0.79767417
80MP0005330_cardiomyopathy0.79123348
81MP0005503_abnormal_tendon_morphology0.77674681
82MP0000350_abnormal_cell_proliferation0.77633655
83MP0002733_abnormal_thermal_nociception0.77414420
84MP0004957_abnormal_blastocyst_morpholog0.77402301
85MP0000639_abnormal_adrenal_gland0.77347700
86MP0006036_abnormal_mitochondrial_physio0.77143937
87MP0002160_abnormal_reproductive_system0.72082169
88MP0005623_abnormal_meninges_morphology0.70220440
89MP0008873_increased_physiological_sensi0.69395764
90MP0001186_pigmentation_phenotype0.68891598
91MP0002009_preneoplasia0.68470059
92MP0001986_abnormal_taste_sensitivity0.68422366
93MP0002060_abnormal_skin_morphology0.68218406
94MP0002970_abnormal_white_adipose0.66159218
95MP0002019_abnormal_tumor_incidence0.65349766
96MP0000467_abnormal_esophagus_morphology0.63955358
97MP0009672_abnormal_birth_weight0.61752387
98MP0005319_abnormal_enzyme/_coenzyme0.61582159
99MP0005083_abnormal_biliary_tract0.59288665
100MP0003937_abnormal_limbs/digits/tail_de0.58070900

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.62671880
2Chromsome breakage (HP:0040012)5.58746711
3Lipid accumulation in hepatocytes (HP:0006561)5.53915969
4Absent rod-and cone-mediated responses on ERG (HP:0007688)5.15173040
5Abnormality of pyrimidine metabolism (HP:0004353)4.91670595
6Decreased electroretinogram (ERG) amplitude (HP:0000654)4.75632015
7Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.46885429
8Dyschromatopsia (HP:0007641)4.42572917
9Duplicated collecting system (HP:0000081)4.09963798
10Ureteral duplication (HP:0000073)3.81259422
11Abnormality of the ileum (HP:0001549)3.52330132
12Severe visual impairment (HP:0001141)3.48650268
13Abnormality of the renal collecting system (HP:0004742)3.47848922
14Abnormality of DNA repair (HP:0003254)3.45937680
15Vitreoretinal degeneration (HP:0000655)3.41878504
16Abnormality of liposaccharide metabolism (HP:0010968)3.40321013
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.40321013
18Abnormality of glycolipid metabolism (HP:0010969)3.40321013
19Pancreatic islet-cell hyperplasia (HP:0004510)3.39610716
20Cerebral hemorrhage (HP:0001342)3.25688674
21Volvulus (HP:0002580)3.20826265
22Mitochondrial inheritance (HP:0001427)3.14020575
23Enlarged penis (HP:0000040)3.05966196
24Rhabdomyolysis (HP:0003201)3.02112637
25Pigmentary retinal degeneration (HP:0001146)2.90418017
26Fatigue (HP:0012378)2.88981424
27Hyperlipoproteinemia (HP:0010980)2.88842452
28Facial hemangioma (HP:0000329)2.86681789
29Meckel diverticulum (HP:0002245)2.86039129
30Deep palmar crease (HP:0006191)2.82786306
31Thin bony cortex (HP:0002753)2.79442527
32Increased hepatocellular lipid droplets (HP:0006565)2.77206254
33Abnormality of the preputium (HP:0100587)2.76357336
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.74732934
35Overlapping toe (HP:0001845)2.69884550
36Renal Fanconi syndrome (HP:0001994)2.67682223
37Increased muscle lipid content (HP:0009058)2.66256285
38Large for gestational age (HP:0001520)2.64987578
39Abnormality of fatty-acid metabolism (HP:0004359)2.60285623
40Enlarged kidneys (HP:0000105)2.58313769
41Abnormal rod and cone electroretinograms (HP:0008323)2.58151331
42Fair hair (HP:0002286)2.57588634
43Broad alveolar ridges (HP:0000187)2.54017209
44Hypophosphatemic rickets (HP:0004912)2.48085296
45Intestinal atresia (HP:0011100)2.45717201
46Clubbing of toes (HP:0100760)2.45038944
47Exertional dyspnea (HP:0002875)2.43855694
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.40596109
49Abnormality of the labia minora (HP:0012880)2.35679790
50Poor speech (HP:0002465)2.32182225
51Thrombocytosis (HP:0001894)2.30633877
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29898399
53Absent radius (HP:0003974)2.23945758
54Unilateral renal agenesis (HP:0000122)2.22232891
55Horseshoe kidney (HP:0000085)2.22201607
56Arteriovenous malformation (HP:0100026)2.21104730
57Elevated erythrocyte sedimentation rate (HP:0003565)2.16173623
58Myelodysplasia (HP:0002863)2.15954581
59Albinism (HP:0001022)2.14479237
60Orthostatic hypotension (HP:0001278)2.11796579
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10985492
62Absent forearm bone (HP:0003953)2.09254711
63Aplasia involving forearm bones (HP:0009822)2.09254711
64Embryonal renal neoplasm (HP:0011794)2.08952748
65Hypoalphalipoproteinemia (HP:0003233)2.04937201
66Muscle stiffness (HP:0003552)2.03999778
67Prolonged partial thromboplastin time (HP:0003645)2.02943149
68Reticulocytopenia (HP:0001896)1.99942868
69Abnormality of chromosome stability (HP:0003220)1.97967701
70Knee flexion contracture (HP:0006380)1.97158486
71Nephroblastoma (Wilms tumor) (HP:0002667)1.96318877
72Genu recurvatum (HP:0002816)1.94313862
73Enlarged epiphyses (HP:0010580)1.93662315
74Abnormality of the intrinsic pathway (HP:0010989)1.93617240
75Absent speech (HP:0001344)1.92630251
76Narrow palate (HP:0000189)1.92070907
77Pendular nystagmus (HP:0012043)1.88191846
78Epidermoid cyst (HP:0200040)1.87811380
79Abnormality of the alveolar ridges (HP:0006477)1.83980502
80Wide intermamillary distance (HP:0006610)1.82119086
81Progressive microcephaly (HP:0000253)1.81365999
82Myoglobinuria (HP:0002913)1.81265207
83Ulnar deviation of the wrist (HP:0003049)1.80423529
84Hepatocellular necrosis (HP:0001404)1.79678883
85Gingival bleeding (HP:0000225)1.79345438
86Abnormality of the common coagulation pathway (HP:0010990)1.79121909
87Epiphyseal stippling (HP:0010655)1.79084514
88Ureteral stenosis (HP:0000071)1.78213909
89Bulbous nose (HP:0000414)1.76443954
90Hemoptysis (HP:0002105)1.73498235
91Hematuria (HP:0000790)1.73212113
92Amyloidosis (HP:0011034)1.72870827
93Sloping forehead (HP:0000340)1.69053095
94Abnormality of the pancreatic islet cells (HP:0006476)1.68798252
95Abnormality of endocrine pancreas physiology (HP:0012093)1.68798252
96Type I transferrin isoform profile (HP:0003642)1.67142301
97Periodontitis (HP:0000704)1.65916254
98Small intestinal stenosis (HP:0012848)1.63741179
99Duodenal stenosis (HP:0100867)1.63741179
100Abnormal hair whorl (HP:0010721)1.63669179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.31548978
2MST44.26734879
3CDK123.84210764
4PRKD33.30284216
5BRD42.87404486
6CHEK22.85800393
7VRK22.74564176
8PKN22.38000865
9CDK62.28316638
10CDK42.15279256
11GRK72.12216974
12TGFBR22.12189045
13MAP3K122.06323898
14TNK22.00514801
15TTK1.99836357
16DDR21.95209469
17BMPR1B1.90298953
18STK101.58553625
19EIF2AK21.55542098
20ATR1.54198530
21GRK51.50662297
22DAPK11.49650189
23PAK21.43227319
24ZAP701.42621629
25ERN11.42034936
26RIPK11.33707406
27MYLK1.30285048
28STK381.29476585
29TEC1.20477006
30DYRK31.15988206
31MOS1.14200450
32CLK11.07517360
33SCYL21.05738026
34MAP3K41.04466058
35CDK91.03038908
36AURKB1.00539945
37CDK80.98104524
38NEK20.95870385
39MAP2K60.95192601
40VRK10.93271314
41PAK10.91365528
42CHEK10.90278615
43ZAK0.85087947
44KDR0.82344298
45PAK40.79460923
46EIF2AK30.79379527
47TRIB30.79059684
48PAK30.78882754
49PRKCI0.76523033
50TYK20.75935660
51ADRBK10.75730875
52PLK30.75015786
53MAP3K60.72753026
54MST1R0.70537609
55ATM0.69506011
56TRPM70.69107382
57LATS10.67127510
58INSRR0.66711901
59NUAK10.64945259
60INSR0.64773689
61PLK10.64490536
62PNCK0.62992003
63PRKD10.62553084
64MTOR0.61949779
65FRK0.61894168
66PLK40.61219807
67HIPK20.60099326
68MAP3K50.59717393
69CSNK2A20.58921615
70PIM20.58788756
71SYK0.58184805
72STK40.58101025
73WEE10.53884340
74MAP4K10.52614134
75MINK10.52440953
76CDK10.51705412
77KIT0.48107413
78FLT30.47678801
79HCK0.44741723
80FGFR10.44687755
81MAP3K20.43165726
82PRKCQ0.42625863
83AKT10.41836143
84PTK2B0.40331053
85BRAF0.40015246
86PRKDC0.39903408
87PIK3CA0.39899317
88CAMK2D0.39760969
89RPS6KA40.39671476
90ABL10.39372795
91ADRBK20.39340627
92YES10.38103675
93AURKA0.37932766
94AKT30.37920660
95PRKACB0.35688874
96RPS6KB20.35357869
97PLK20.35260578
98RET0.33758287
99CSNK2A10.33626650
100CDK20.31166751

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.84308708
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.70357559
3DNA replication_Homo sapiens_hsa030304.08677350
4Base excision repair_Homo sapiens_hsa034103.25545439
5One carbon pool by folate_Homo sapiens_hsa006702.89578116
6Non-homologous end-joining_Homo sapiens_hsa034502.74576124
7Lysine degradation_Homo sapiens_hsa003102.45836863
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28027960
9Fatty acid degradation_Homo sapiens_hsa000712.18689756
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03118256
11Synaptic vesicle cycle_Homo sapiens_hsa047211.99396801
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99295065
13Fatty acid metabolism_Homo sapiens_hsa012121.91835939
14Glycerophospholipid metabolism_Homo sapiens_hsa005641.67017182
15Pyrimidine metabolism_Homo sapiens_hsa002401.65350293
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63602463
17Vibrio cholerae infection_Homo sapiens_hsa051101.62716367
18Nucleotide excision repair_Homo sapiens_hsa034201.60855988
19Collecting duct acid secretion_Homo sapiens_hsa049661.55763564
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47854187
21Mismatch repair_Homo sapiens_hsa034301.45988371
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43614606
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.36829590
24Galactose metabolism_Homo sapiens_hsa000521.36262836
25Peroxisome_Homo sapiens_hsa041461.33474085
26Regulation of autophagy_Homo sapiens_hsa041401.31612107
27Shigellosis_Homo sapiens_hsa051311.29628601
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28940300
29Other glycan degradation_Homo sapiens_hsa005111.27360664
30RNA transport_Homo sapiens_hsa030131.25047667
31Cell cycle_Homo sapiens_hsa041101.24140389
32Homologous recombination_Homo sapiens_hsa034401.23440749
33Tryptophan metabolism_Homo sapiens_hsa003801.22818390
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.22113964
35Proteasome_Homo sapiens_hsa030501.21472327
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.19028300
37Lysosome_Homo sapiens_hsa041421.18948505
38Oxidative phosphorylation_Homo sapiens_hsa001901.15356182
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15278225
40Fatty acid elongation_Homo sapiens_hsa000621.14400081
41Huntingtons disease_Homo sapiens_hsa050161.06166429
42RNA polymerase_Homo sapiens_hsa030201.05629936
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04706400
44Butanoate metabolism_Homo sapiens_hsa006501.03400224
45Glutathione metabolism_Homo sapiens_hsa004801.01740807
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01285590
47Spliceosome_Homo sapiens_hsa030400.97885741
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.95284816
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90758987
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88259501
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85483494
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84245462
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83190210
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80066094
55Complement and coagulation cascades_Homo sapiens_hsa046100.76527511
56RNA degradation_Homo sapiens_hsa030180.75705610
57Protein digestion and absorption_Homo sapiens_hsa049740.75496151
58N-Glycan biosynthesis_Homo sapiens_hsa005100.72241507
59Renin-angiotensin system_Homo sapiens_hsa046140.66118828
60Choline metabolism in cancer_Homo sapiens_hsa052310.61993903
61Metabolic pathways_Homo sapiens_hsa011000.61469276
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61269775
63Thyroid hormone synthesis_Homo sapiens_hsa049180.61243512
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55787711
65Carbon metabolism_Homo sapiens_hsa012000.53378156
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51404305
67Melanoma_Homo sapiens_hsa052180.51340593
68Ribosome_Homo sapiens_hsa030100.49401017
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47708823
70beta-Alanine metabolism_Homo sapiens_hsa004100.45848495
71ECM-receptor interaction_Homo sapiens_hsa045120.44726156
72PPAR signaling pathway_Homo sapiens_hsa033200.44698995
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42624463
74p53 signaling pathway_Homo sapiens_hsa041150.41348362
75Fructose and mannose metabolism_Homo sapiens_hsa000510.41312607
76Proteoglycans in cancer_Homo sapiens_hsa052050.40538427
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40345435
78Tyrosine metabolism_Homo sapiens_hsa003500.40165485
79Protein export_Homo sapiens_hsa030600.39621286
80Steroid biosynthesis_Homo sapiens_hsa001000.39617044
81Phototransduction_Homo sapiens_hsa047440.38904018
82Glycerolipid metabolism_Homo sapiens_hsa005610.38465888
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37107802
84Pertussis_Homo sapiens_hsa051330.36215679
85Parkinsons disease_Homo sapiens_hsa050120.34800287
86Retinol metabolism_Homo sapiens_hsa008300.32380013
87Alzheimers disease_Homo sapiens_hsa050100.31764792
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31391862
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31279870
90mRNA surveillance pathway_Homo sapiens_hsa030150.31101429
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29538838
92Pentose phosphate pathway_Homo sapiens_hsa000300.26483869
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26307040
94Arachidonic acid metabolism_Homo sapiens_hsa005900.25951374
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23356817
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23231608
97Focal adhesion_Homo sapiens_hsa045100.22617114
98Malaria_Homo sapiens_hsa051440.22146625
99Systemic lupus erythematosus_Homo sapiens_hsa053220.19412720
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18075218

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