ERLIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.35738902
2Golgi transport vesicle coating (GO:0048200)4.35738902
3lung epithelium development (GO:0060428)4.30582074
4desmosome organization (GO:0002934)4.19130711
5epithelial cell differentiation involved in prostate gland development (GO:0060742)3.99362504
6establishment of apical/basal cell polarity (GO:0035089)3.68393852
7regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.66171870
8embryonic foregut morphogenesis (GO:0048617)3.59114751
9renal filtration (GO:0097205)3.51739843
10iron ion import (GO:0097286)3.50436838
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.48260324
12bundle of His cell to Purkinje myocyte communication (GO:0086069)3.43721570
13dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.40205686
14glomerular basement membrane development (GO:0032836)3.38514042
15G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.37566963
16alpha-linolenic acid metabolic process (GO:0036109)3.30477705
17lysine catabolic process (GO:0006554)3.30460856
18lysine metabolic process (GO:0006553)3.30460856
19regulation of hippo signaling (GO:0035330)3.28486688
20skin morphogenesis (GO:0043589)3.24747979
21establishment or maintenance of monopolar cell polarity (GO:0061339)3.24618995
22establishment of monopolar cell polarity (GO:0061162)3.24618995
23Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.22241025
24nuclear pore complex assembly (GO:0051292)3.19379573
25hippo signaling (GO:0035329)3.18353152
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16074583
27regulation of establishment of planar polarity (GO:0090175)3.11878205
28adherens junction assembly (GO:0034333)3.07063599
29hemidesmosome assembly (GO:0031581)3.05162243
30cell adhesion mediated by integrin (GO:0033627)3.02778006
31glomerular filtration (GO:0003094)2.99972293
32cell-substrate junction assembly (GO:0007044)2.99490449
33protein hydroxylation (GO:0018126)2.98141332
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97632677
35retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.95636150
36paraxial mesoderm development (GO:0048339)2.94700779
37drug transmembrane transport (GO:0006855)2.94046457
38peptidyl-proline hydroxylation (GO:0019511)2.93219778
39cytoskeletal anchoring at plasma membrane (GO:0007016)2.92493291
40renal system development (GO:0072001)2.91509874
41sequestering of extracellular ligand from receptor (GO:0035581)2.87997438
42cell-substrate adherens junction assembly (GO:0007045)2.87362002
43focal adhesion assembly (GO:0048041)2.87362002
44neuron projection extension involved in neuron projection guidance (GO:1902284)2.87259174
45axon extension involved in axon guidance (GO:0048846)2.87259174
46planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83536216
47chondrocyte development (GO:0002063)2.83497140
48positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.82611903
49protein retention in ER lumen (GO:0006621)2.82280911
50apoptotic cell clearance (GO:0043277)2.81073451
51biotin metabolic process (GO:0006768)2.81004165
52collagen fibril organization (GO:0030199)2.80889688
53chondrocyte proliferation (GO:0035988)2.80863886
54glomerular epithelial cell development (GO:0072310)2.79706022
55regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.79645652
56ectoderm development (GO:0007398)2.79422303
57endodermal cell differentiation (GO:0035987)2.76006488
58gap junction assembly (GO:0016264)2.75890281
594-hydroxyproline metabolic process (GO:0019471)2.73834582
60nuclear pore organization (GO:0006999)2.72717975
61midgut development (GO:0007494)2.70033739
62branching involved in salivary gland morphogenesis (GO:0060445)2.69476231
63epithelial cell-cell adhesion (GO:0090136)2.69176426
64non-canonical Wnt signaling pathway (GO:0035567)2.68344421
65phosphate ion transport (GO:0006817)2.67031791
66macroautophagy (GO:0016236)2.66966879
67regulation of glucose import in response to insulin stimulus (GO:2001273)2.66077285
68cellular response to vitamin (GO:0071295)2.61843359
69basement membrane organization (GO:0071711)2.61344234
70mammary gland epithelial cell differentiation (GO:0060644)2.61159311
71regulation of translational fidelity (GO:0006450)2.60535421
72cellular response to vitamin D (GO:0071305)2.60130867
73activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59966910
74branching involved in mammary gland duct morphogenesis (GO:0060444)2.58657447
75polarized epithelial cell differentiation (GO:0030859)2.58632184
76negative regulation of fatty acid transport (GO:2000192)2.58155189
77renal absorption (GO:0070293)2.57752465
78collecting duct development (GO:0072044)2.55650325
79amino-acid betaine transport (GO:0015838)2.54685282
80carnitine transport (GO:0015879)2.54685282
81convergent extension (GO:0060026)2.54642421
82negative regulation of smooth muscle cell migration (GO:0014912)2.49800323
83notochord development (GO:0030903)2.49795572
84negative regulation of chondrocyte differentiation (GO:0032331)2.49742718
85regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.49381976
86bone trabecula formation (GO:0060346)2.49275817
87vesicle coating (GO:0006901)2.48963017
88insulin-like growth factor receptor signaling pathway (GO:0048009)2.48022416
89carnitine transmembrane transport (GO:1902603)2.47058353
90positive regulation of fatty acid beta-oxidation (GO:0032000)2.46596059
91cellular copper ion homeostasis (GO:0006878)2.46261014
92protein localization to endosome (GO:0036010)2.46161942
93regulation of cholesterol homeostasis (GO:2000188)2.45255031
94membrane protein ectodomain proteolysis (GO:0006509)2.44966560
95lung lobe morphogenesis (GO:0060463)2.44639701
96regulation of fatty acid beta-oxidation (GO:0031998)2.44076666
97quaternary ammonium group transport (GO:0015697)2.43913134
98prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.42388984
99positive regulation of nuclease activity (GO:0032075)2.40109909
100positive regulation of catenin import into nucleus (GO:0035413)2.39943005
101proline biosynthetic process (GO:0006561)2.39567967
102lung-associated mesenchyme development (GO:0060484)2.38439506
103cellular modified amino acid catabolic process (GO:0042219)2.38389480
104positive regulation of hormone biosynthetic process (GO:0046886)2.38320843
105drug transport (GO:0015893)2.38069204
106anterior/posterior axis specification, embryo (GO:0008595)2.37122332
107regulation of transforming growth factor beta2 production (GO:0032909)2.36595902
108intestinal absorption (GO:0050892)2.36529525
109cysteine metabolic process (GO:0006534)2.36252522
110primary alcohol catabolic process (GO:0034310)2.35630251
111hormone catabolic process (GO:0042447)2.34573973
112establishment or maintenance of apical/basal cell polarity (GO:0035088)2.33402048
113establishment or maintenance of bipolar cell polarity (GO:0061245)2.33402048
114apical protein localization (GO:0045176)2.32837835
115COPII vesicle coating (GO:0048208)2.30572615
116endoplasmic reticulum unfolded protein response (GO:0030968)2.29457071
117regulation of RNA export from nucleus (GO:0046831)2.28756537
118ER overload response (GO:0006983)2.28410410
119positive regulation of endothelial cell apoptotic process (GO:2000353)2.28216613
120peptide catabolic process (GO:0043171)2.28131827
121ethanol metabolic process (GO:0006067)2.27072847
122lens fiber cell development (GO:0070307)2.26328599
123endocardial cushion development (GO:0003197)2.26237688
124glial cell proliferation (GO:0014009)2.25903744
125endothelial cell morphogenesis (GO:0001886)2.25503948
126protein localization to cell surface (GO:0034394)2.25443865
127low-density lipoprotein particle clearance (GO:0034383)2.25343374
128negative regulation of keratinocyte proliferation (GO:0010839)2.24789034
129heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.22821807
130mesenchymal-epithelial cell signaling (GO:0060638)2.22665711
131negative regulation of DNA repair (GO:0045738)2.21818664
132negative regulation of protein localization to plasma membrane (GO:1903077)2.21443308
133lateral sprouting from an epithelium (GO:0060601)2.20809271
134collagen metabolic process (GO:0032963)2.20537719
135cellular response to unfolded protein (GO:0034620)2.20336982
136regulation of cell fate specification (GO:0042659)2.19888273
137multicellular organismal macromolecule metabolic process (GO:0044259)2.19180288
138ER-nucleus signaling pathway (GO:0006984)2.18297540
139phosphate ion transmembrane transport (GO:0035435)2.18265119
140fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.18047740
141growth hormone receptor signaling pathway (GO:0060396)2.18015456
142semaphorin-plexin signaling pathway (GO:0071526)2.17846381
143glyoxylate metabolic process (GO:0046487)2.17835181
144positive regulation of glycogen biosynthetic process (GO:0045725)2.17131674
145regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.16942033
146glucocorticoid receptor signaling pathway (GO:0042921)2.16444015
147tricarboxylic acid metabolic process (GO:0072350)2.16101749
148dorsal/ventral axis specification (GO:0009950)2.15755101
149positive regulation of glycoprotein metabolic process (GO:1903020)2.15538222
150negative regulation of humoral immune response (GO:0002921)2.15314608
151layer formation in cerebral cortex (GO:0021819)2.15214675
152sulfur amino acid catabolic process (GO:0000098)2.14219240
153Notch signaling involved in heart development (GO:0061314)2.11776553
154gastrulation with mouth forming second (GO:0001702)2.11241180
155cell migration involved in sprouting angiogenesis (GO:0002042)2.11200410
156positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.10594261
157establishment of tissue polarity (GO:0007164)2.09671060
158establishment of planar polarity (GO:0001736)2.09671060
159regulation of nuclease activity (GO:0032069)2.09514787
160nephron tubule development (GO:0072080)2.08530391
161camera-type eye morphogenesis (GO:0048593)2.08198759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.16645756
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.75171893
3CLOCK_20551151_ChIP-Seq_293T_Human3.28194379
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.74406342
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.65650985
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.61238094
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.59091000
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58487336
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56787789
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48053573
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.28322973
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.13860697
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.12408755
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94927708
15SOX2_27498859_Chip-Seq_STOMACH_Mouse1.92009728
16WT1_19549856_ChIP-ChIP_CCG9911_Human1.91799603
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81629724
18SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.81479855
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.79886071
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.79705362
21* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79179647
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78218883
23E2F7_22180533_ChIP-Seq_HELA_Human1.77989121
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71323561
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67678218
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67425710
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66405626
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66131620
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65230560
30CHD1_26751641_Chip-Seq_LNCaP_Human1.60669422
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60525938
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60408284
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58885949
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54680316
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52154839
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51473437
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.51165275
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50806874
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50422623
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48847284
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48741512
42SOX2_20726797_ChIP-Seq_SW620_Human1.47584695
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47326148
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47069994
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46804591
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.43975943
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.43448061
48GATA4_25053715_ChIP-Seq_YYC3_Human1.39727118
49* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39694631
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.39291365
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38070300
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37209280
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36033484
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34719335
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33585174
56GATA6_25053715_ChIP-Seq_YYC3_Human1.33574242
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.31468216
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30598974
59ZNF263_19887448_ChIP-Seq_K562_Human1.29846838
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29738285
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28207393
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28193134
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.25961538
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21085841
65RACK7_27058665_Chip-Seq_MCF-7_Human1.20405075
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18961827
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.18729046
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18515359
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17634927
70KDM2B_26808549_Chip-Seq_K562_Human1.16598427
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.16334404
72* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16037301
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15716921
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15716921
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15507057
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15253378
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.15042901
78AHR_22903824_ChIP-Seq_MCF-7_Human1.14574409
79FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14274374
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12446329
81CJUN_26792858_Chip-Seq_BT549_Human1.11949778
82KLF5_25053715_ChIP-Seq_YYC3_Human1.11797299
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11792153
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11658212
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.10365600
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10320148
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08794349
88* ATF3_27146783_Chip-Seq_COLON_Human1.08578931
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07355803
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06994448
91LXR_22292898_ChIP-Seq_THP-1_Human1.06800728
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05932560
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05881343
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.05603851
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.05314927
96TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05105563
97GATA3_24758297_ChIP-Seq_MCF-7_Human1.04086111
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02609729
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01924047
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01778528
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00887945
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00202568
103FOXA1_25552417_ChIP-Seq_VCAP_Human1.00152464
104AR_21909140_ChIP-Seq_LNCAP_Human0.99152638
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98303213
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97798200
107TBX20_22328084_ChIP-Seq_HEART_Mouse0.96676052
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.96676052
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95208429
110GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94966587
111TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94846356
112BRD4_25478319_ChIP-Seq_HGPS_Human0.94686991
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.94513388
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94506690
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94179445
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94075900
117CREB1_26743006_Chip-Seq_LNCaP_Human0.93681974
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92491804
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91220036
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90844515
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90595611
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90595611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.78434185
2MP0003283_abnormal_digestive_organ3.09441860
3MP0003705_abnormal_hypodermis_morpholog2.82962511
4MP0005360_urolithiasis2.80819759
5MP0004272_abnormal_basement_membrane2.66483716
6MP0002254_reproductive_system_inflammat2.65904285
7MP0003300_gastrointestinal_ulcer2.60099968
8MP0002139_abnormal_hepatobiliary_system2.51670201
9MP0000537_abnormal_urethra_morphology2.50340587
10MP0006054_spinal_hemorrhage2.44303131
11MP0009384_cardiac_valve_regurgitation2.34363610
12MP0003252_abnormal_bile_duct2.25658932
13MP0001849_ear_inflammation2.09891580
14MP0005503_abnormal_tendon_morphology1.95209538
15MP0005257_abnormal_intraocular_pressure1.94101326
16MP0003566_abnormal_cell_adhesion1.91682718
17MP0009780_abnormal_chondrocyte_physiolo1.88806268
18MP0005076_abnormal_cell_differentiation1.82636176
19MP0010678_abnormal_skin_adnexa1.80524094
20MP0004019_abnormal_vitamin_homeostasis1.79629033
21MP0002653_abnormal_ependyma_morphology1.79503795
22MP0002138_abnormal_hepatobiliary_system1.79444137
23MP0004264_abnormal_extraembryonic_tissu1.74481740
24MP0003941_abnormal_skin_development1.72372122
25MP0005623_abnormal_meninges_morphology1.69090284
26MP0002060_abnormal_skin_morphology1.66826456
27MP0010030_abnormal_orbit_morphology1.65661643
28MP0008438_abnormal_cutaneous_collagen1.62547141
29MP0001666_abnormal_nutrient_absorption1.58530087
30MP0000467_abnormal_esophagus_morphology1.56625211
31MP0009053_abnormal_anal_canal1.54687334
32MP0005248_abnormal_Harderian_gland1.51910897
33MP0003172_abnormal_lysosome_physiology1.51478643
34MP0003279_aneurysm1.50719993
35MP0001958_emphysema1.48683702
36MP0005058_abnormal_lysosome_morphology1.48459964
37MP0001661_extended_life_span1.48297577
38MP0008961_abnormal_basal_metabolism1.48212376
39MP0005409_darkened_coat_color1.45760783
40MP0002896_abnormal_bone_mineralization1.45067792
41MP0002796_impaired_skin_barrier1.42575567
42MP0010352_gastrointestinal_tract_polyps1.41029324
43MP0002009_preneoplasia1.39114672
44MP0004043_abnormal_pH_regulation1.38325172
45MP0005220_abnormal_exocrine_pancreas1.36942707
46MP0005167_abnormal_blood-brain_barrier1.36375296
47MP0005083_abnormal_biliary_tract1.36170909
48MP0000579_abnormal_nail_morphology1.35654285
49MP0004858_abnormal_nervous_system1.33834056
50MP0009643_abnormal_urine_homeostasis1.33020975
51MP0000383_abnormal_hair_follicle1.32208869
52MP0005365_abnormal_bile_salt1.31059795
53MP0000566_synostosis1.31051406
54MP0003115_abnormal_respiratory_system1.30464247
55MP0005275_abnormal_skin_tensile1.29498374
56MP0000462_abnormal_digestive_system1.29308572
57MP0000762_abnormal_tongue_morphology1.28114261
58MP0003942_abnormal_urinary_system1.27615604
59MP0003950_abnormal_plasma_membrane1.24399314
60MP0010329_abnormal_lipoprotein_level1.22902071
61MP0002877_abnormal_melanocyte_morpholog1.22102692
62MP0001299_abnormal_eye_distance/1.22098614
63MP0002928_abnormal_bile_duct1.21312040
64MP0000534_abnormal_ureter_morphology1.19623953
65MP0005085_abnormal_gallbladder_physiolo1.17727770
66MP0002234_abnormal_pharynx_morphology1.16461325
67MP0001881_abnormal_mammary_gland1.16452711
68MP0000627_abnormal_mammary_gland1.15596404
69MP0003453_abnormal_keratinocyte_physiol1.15283859
70MP0004233_abnormal_muscle_weight1.12944364
71MP0005332_abnormal_amino_acid1.12312295
72MP0000767_abnormal_smooth_muscle1.11703695
73MP0002092_abnormal_eye_morphology1.11645208
74MP0000538_abnormal_urinary_bladder1.09284305
75MP0005023_abnormal_wound_healing1.08745805
76MP0001346_abnormal_lacrimal_gland1.07286181
77MP0009672_abnormal_birth_weight1.07126230
78MP0001915_intracranial_hemorrhage1.06504312
79MP0010368_abnormal_lymphatic_system1.06407855
80MP0002909_abnormal_adrenal_gland1.05353151
81MP0005408_hypopigmentation1.04790983
82MP0005377_hearing/vestibular/ear_phenot1.04581586
83MP0003878_abnormal_ear_physiology1.04581586
84MP0004885_abnormal_endolymph1.04268366
85MP0001756_abnormal_urination1.01820341
86MP0000377_abnormal_hair_follicle1.01528544
87MP0002108_abnormal_muscle_morphology1.01414108
88MP0002098_abnormal_vibrissa_morphology1.00475919
89MP0000428_abnormal_craniofacial_morphol0.99701620
90MP0004133_heterotaxia0.99694847
91MP0003183_abnormal_peptide_metabolism0.99235545
92MP0003868_abnormal_feces_composition0.98441873
93MP0005501_abnormal_skin_physiology0.95781284
94MP0002084_abnormal_developmental_patter0.95460419
95MP0002086_abnormal_extraembryonic_tissu0.95333394
96MP0002089_abnormal_postnatal_growth/wei0.94900185
97MP0004782_abnormal_surfactant_physiolog0.94552610
98MP0002168_other_aberrant_phenotype0.93682715
99MP0003984_embryonic_growth_retardation0.91468168
100MP0002697_abnormal_eye_size0.91457339
101MP0005187_abnormal_penis_morphology0.91298496
102MP0002088_abnormal_embryonic_growth/wei0.90681121
103MP0002090_abnormal_vision0.89261880
104MP0003937_abnormal_limbs/digits/tail_de0.89253328
105MP0002282_abnormal_trachea_morphology0.89191184
106MP0000013_abnormal_adipose_tissue0.88579374
107MP0000432_abnormal_head_morphology0.87906084
108MP0005666_abnormal_adipose_tissue0.87338532
109MP0003690_abnormal_glial_cell0.86864397
110MP0003191_abnormal_cellular_cholesterol0.86749326
111MP0001672_abnormal_embryogenesis/_devel0.86479187
112MP0005380_embryogenesis_phenotype0.86479187
113MP0003195_calcinosis0.85490346
114MP0003385_abnormal_body_wall0.85318887
115MP0008875_abnormal_xenobiotic_pharmacok0.83124427
116MP0000003_abnormal_adipose_tissue0.82667696
117MP0001216_abnormal_epidermal_layer0.82637059
118MP0009840_abnormal_foam_cell0.82164447
119MP0002085_abnormal_embryonic_tissue0.82000394
120MP0003119_abnormal_digestive_system0.81892754
121MP0005508_abnormal_skeleton_morphology0.80838176
122MP0002111_abnormal_tail_morphology0.79991064
123MP0004084_abnormal_cardiac_muscle0.79437497
124MP0002295_abnormal_pulmonary_circulatio0.79400751
125MP0001944_abnormal_pancreas_morphology0.78083492
126MP0005375_adipose_tissue_phenotype0.77830415
127MP0001243_abnormal_dermal_layer0.76594847
128MP0002925_abnormal_cardiovascular_devel0.76198704
129MP0010630_abnormal_cardiac_muscle0.76186686
130MP0009703_decreased_birth_body0.76097058
131MP0000733_abnormal_muscle_development0.75359627
132MP0003091_abnormal_cell_migration0.74862035
133MP0002136_abnormal_kidney_physiology0.74638464
134MP0001293_anophthalmia0.74024667
135MP0002166_altered_tumor_susceptibility0.73531684
136MP0001765_abnormal_ion_homeostasis0.72712120
137MP0006138_congestive_heart_failure0.71995039
138MP0004185_abnormal_adipocyte_glucose0.70680985
139MP0000647_abnormal_sebaceous_gland0.69916261
140MP0002932_abnormal_joint_morphology0.68562592

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.13376435
2Cerebral aneurysm (HP:0004944)3.03648197
3Abnormality of dentin (HP:0010299)2.87598016
4Hand muscle atrophy (HP:0009130)2.87523380
5Aortic aneurysm (HP:0004942)2.85696740
6Right ventricular cardiomyopathy (HP:0011663)2.84740054
7Gout (HP:0001997)2.82560016
8Cervical subluxation (HP:0003308)2.75348590
9Abnormality of glutamine family amino acid metabolism (HP:0010902)2.67630997
10Arterial tortuosity (HP:0005116)2.67403908
11Vascular tortuosity (HP:0004948)2.67153714
12Urinary glycosaminoglycan excretion (HP:0003541)2.65274623
13Mucopolysacchariduria (HP:0008155)2.65274623
14Dysostosis multiplex (HP:0000943)2.63845136
15Wormian bones (HP:0002645)2.58308911
16Hydroxyprolinuria (HP:0003080)2.57885821
17Abnormality of proline metabolism (HP:0010907)2.57885821
18Soft skin (HP:0000977)2.51803566
19Sparse lateral eyebrow (HP:0005338)2.50552556
20Abnormality of polysaccharide metabolism (HP:0011012)2.49734269
21Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49734269
22Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49734269
23Neonatal short-limb short stature (HP:0008921)2.46188282
24Lymphangioma (HP:0100764)2.40248979
25Abnormality of chloride homeostasis (HP:0011422)2.37027360
26Distal upper limb amyotrophy (HP:0007149)2.36636974
27Upper limb amyotrophy (HP:0009129)2.36636974
28Vertebral compression fractures (HP:0002953)2.36181848
29Broad metatarsal (HP:0001783)2.35366241
30Fragile skin (HP:0001030)2.33091374
31Hyperactive renin-angiotensin system (HP:0000841)2.32673890
32Asymmetry of the thorax (HP:0001555)2.30962195
33Abnormality of carpal bone ossification (HP:0006257)2.28660969
34Blue sclerae (HP:0000592)2.27804217
35Increased circulating renin level (HP:0000848)2.26563260
36Advanced eruption of teeth (HP:0006288)2.26329134
37Aneurysm (HP:0002617)2.25777101
38Natal tooth (HP:0000695)2.24639345
39Abnormal ossification of hand bones (HP:0005921)2.24293349
40Focal segmental glomerulosclerosis (HP:0000097)2.22441792
41Protrusio acetabuli (HP:0003179)2.21591632
42Ketoacidosis (HP:0001993)2.21231075
43Spinal rigidity (HP:0003306)2.21113962
44Abnormality of the acetabulum (HP:0003170)2.18465696
45Bronchomalacia (HP:0002780)2.16177266
46Back pain (HP:0003418)2.16079768
47Premature rupture of membranes (HP:0001788)2.13562080
48Abnormal pancreas size (HP:0012094)2.12710199
49Ankyloglossia (HP:0010296)2.11009981
50Hypokalemic alkalosis (HP:0001949)2.10894830
51Short nail (HP:0001799)2.09858680
52Spinal muscular atrophy (HP:0007269)2.09268759
53Abnormality of the distal phalanx of the thumb (HP:0009617)2.09258981
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08488103
55Glomerulosclerosis (HP:0000096)2.04703982
56Biconcave vertebral bodies (HP:0004586)2.03884634
57Hyperextensible skin (HP:0000974)2.03166256
58Turricephaly (HP:0000262)2.02918370
59Pterygium (HP:0001059)2.02335199
60Abnormal delivery (HP:0001787)2.02119503
61Joint laxity (HP:0001388)2.00760753
62Atrophic scars (HP:0001075)2.00234780
63Hyperacusis (HP:0010780)1.99222344
64Spastic diplegia (HP:0001264)1.98815748
65Germ cell neoplasia (HP:0100728)1.98452332
66Abnormal hand bone ossification (HP:0010660)1.98222162
67Deep venous thrombosis (HP:0002625)1.97687533
68Abnormality of purine metabolism (HP:0004352)1.97350800
69Elfin facies (HP:0004428)1.95666545
70Hypercalciuria (HP:0002150)1.92393474
71Abnormality of renal excretion (HP:0011036)1.92174336
72Genu recurvatum (HP:0002816)1.91894313
73Esophageal varix (HP:0002040)1.91518482
74Exostoses (HP:0100777)1.91477532
75Subacute progressive viral hepatitis (HP:0006572)1.91007208
76Aplasia involving bones of the extremities (HP:0009825)1.90967817
77Aplasia involving bones of the upper limbs (HP:0009823)1.90967817
78Aplasia of the phalanges of the hand (HP:0009802)1.90967817
79Metabolic alkalosis (HP:0200114)1.90400535
80Hepatoblastoma (HP:0002884)1.86139600
81Mitral valve prolapse (HP:0001634)1.84800193
82Thin bony cortex (HP:0002753)1.84289209
83Congenital glaucoma (HP:0001087)1.83322027
84Mitral stenosis (HP:0001718)1.80990705
85Hyperglycinuria (HP:0003108)1.80726448
86Aortic dissection (HP:0002647)1.80539474
87Dilatation of the ascending aorta (HP:0005111)1.80179766
88Abnormal tarsal ossification (HP:0008369)1.80042543
89Arnold-Chiari malformation (HP:0002308)1.78177643
90Macroorchidism (HP:0000053)1.76420072
91Increased purine levels (HP:0004368)1.76222459
92Hyperuricemia (HP:0002149)1.76222459
93Bowel diverticulosis (HP:0005222)1.76074552
94Metaphyseal cupping (HP:0003021)1.75302317
95Visceral angiomatosis (HP:0100761)1.72827532
96Overgrowth (HP:0001548)1.72825927
97Broad face (HP:0000283)1.72445793
98Epiphyseal dysplasia (HP:0002656)1.72323080
99Ulnar bowing (HP:0003031)1.71625120
100Abnormal urine output (HP:0012590)1.70906262
101Missing ribs (HP:0000921)1.70905222
102Mesangial abnormality (HP:0001966)1.70451375
103Spondylolisthesis (HP:0003302)1.70264563
104Breech presentation (HP:0001623)1.70248115
105Abnormality of the distal phalanges of the toes (HP:0010182)1.70151639
106Abnormality of the gastric mucosa (HP:0004295)1.69909591
107Enlarged penis (HP:0000040)1.69811141
108Cardiovascular calcification (HP:0011915)1.68545759
109Coronal craniosynostosis (HP:0004440)1.68397661
110Renal duplication (HP:0000075)1.68144432
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67196219
112Short 4th metacarpal (HP:0010044)1.67196219
113Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.66791421
114Abnormality of monocarboxylic acid metabolism (HP:0010996)1.66749750
115Osteoarthritis (HP:0002758)1.66706421
116Megalencephaly (HP:0001355)1.66190061
117Abnormal foot bone ossification (HP:0010675)1.65643809
118Subcapsular cataract (HP:0000523)1.65320361
119Hypokalemia (HP:0002900)1.63283869
120Deviation of the hallux (HP:0010051)1.63271251
121Flat acetabular roof (HP:0003180)1.62604769
122Bladder diverticulum (HP:0000015)1.62182166
123Spinal cord compression (HP:0002176)1.62135315
124Follicular hyperkeratosis (HP:0007502)1.62119368
125Vascular calcification (HP:0004934)1.61962780
126Vertebral arch anomaly (HP:0008438)1.61780786
127Hypoglycemic seizures (HP:0002173)1.61404036
128Xanthomatosis (HP:0000991)1.61121655
129Chondrocalcinosis (HP:0000934)1.60736917
130Polyuria (HP:0000103)1.60672235
131Abnormality of oral frenula (HP:0000190)1.60345893
132Hematochezia (HP:0002573)1.58900060
133Hallux valgus (HP:0001822)1.58741699
134Skin nodule (HP:0200036)1.58610640
135Long toe (HP:0010511)1.58259156
136Rectal prolapse (HP:0002035)1.57681546
137Abdominal distention (HP:0003270)1.57598716
138Hypoglycemic coma (HP:0001325)1.57102105
139Nephrolithiasis (HP:0000787)1.56676170
140Ankle contracture (HP:0006466)1.56047405
141Coxa vara (HP:0002812)1.55767576
142Hemangiomatosis (HP:0007461)1.55647949
143Buphthalmos (HP:0000557)1.55243465
144Renal salt wasting (HP:0000127)1.54746732
145Flattened epiphyses (HP:0003071)1.54649615
146Abnormality of the pancreatic islet cells (HP:0006476)1.54467351
147Abnormality of endocrine pancreas physiology (HP:0012093)1.54467351
148Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.54290551
149Vertebral hypoplasia (HP:0008417)1.54290551
150Protruding ear (HP:0000411)1.54230746
151Rhizomelia (HP:0008905)1.54110676
152Ovoid vertebral bodies (HP:0003300)1.53981151
153Hypoplastic labia majora (HP:0000059)1.53638172
154Disproportionate tall stature (HP:0001519)1.53451998
155Osteolytic defects of the phalanges of the hand (HP:0009771)1.53145543
156Osteolytic defects of the hand bones (HP:0009699)1.53145543
157Deep philtrum (HP:0002002)1.51592380
158Mildly elevated creatine phosphokinase (HP:0008180)1.51563371
159Elbow flexion contracture (HP:0002987)1.51380395
160Relative macrocephaly (HP:0004482)1.50914023
161Termporal pattern (HP:0011008)1.50531360
162Insidious onset (HP:0003587)1.50531360
163Delayed cranial suture closure (HP:0000270)1.49545045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.38051879
2PASK3.04958938
3EPHB22.83212734
4PTK62.57428297
5SIK12.55822879
6SMG12.50513507
7PKN22.35462752
8TGFBR22.22113532
9ERN12.17896853
10NTRK12.16670321
11PDGFRA2.14487151
12WNK42.12537463
13KSR12.04517150
14EPHA21.96297669
15MST1R1.92747587
16LATS11.87116644
17FER1.85678515
18RIPK11.82531137
19WNK31.71483036
20NEK91.68093139
21MET1.65933735
22LMTK21.63159084
23AKT31.63070530
24PAK41.63038986
25EIF2AK31.59019070
26DDR21.58808497
27RPS6KB21.57552748
28ERBB21.55292470
29FGFR21.55027130
30FRK1.54954646
31PTK21.54802733
32BCR1.53775773
33FGFR41.52247211
34STK101.50931703
35SIK31.48201341
36ERBB31.47461482
37TTK1.40527126
38TESK11.35309789
39CAMKK11.28704072
40TRPM71.27125147
41MAP3K101.26712895
42PNCK1.25311200
43BCKDK1.25243665
44PBK1.24707914
45FGFR11.22147932
46PDK41.16563007
47PDK31.16563007
48TAF11.15975446
49PAK31.13223300
50LRRK21.11953447
51DYRK1B1.11367739
52EIF2AK11.08465650
53SCYL21.08195431
54PDK21.07540706
55MAPKAPK31.07175208
56STK38L1.06857904
57TSSK61.06591793
58NTRK21.03507156
59MTOR1.02664335
60BRD41.01043464
61NEK11.00448435
62MAP3K20.99589507
63CAMK1D0.97341636
64WEE10.89943077
65MAP2K20.89299624
66ICK0.87366967
67EPHA30.85271530
68PAK20.85205641
69EPHB10.84718527
70CAMK1G0.82738908
71TYRO30.82618333
72ERBB40.81449294
73MAPK150.77463866
74FGFR30.77107165
75EEF2K0.75814862
76TGFBR10.74790292
77CDK60.74765735
78MATK0.74240012
79CDK70.73438790
80BRSK10.73386520
81MELK0.72826737
82RET0.71765547
83CDK120.71566425
84MAP3K90.71293729
85NEK60.69881597
86MINK10.68360109
87MAPKAPK50.67975045
88RPS6KB10.67108786
89STK380.67094424
90PAK60.65669930
91FLT30.65649017
92MST40.65159964
93LATS20.65041603
94BMX0.64455629
95MYLK0.63623386
96CDC42BPA0.61472309
97PRKD30.60991512
98MARK10.58877422
99MAP3K80.58316982
100PDGFRB0.57805323
101MAP2K10.57359081
102TTN0.56944393
103MAP3K70.54637206
104STK240.53809824
105GSK3A0.53773848
106RPS6KL10.52309832
107RPS6KC10.52309832
108AKT20.51433472
109KSR20.50278058
110STK390.49802143
111OXSR10.48561006
112EGFR0.48212273
113SRC0.46791192
114EIF2AK20.43827928
115PRKCZ0.43377289
116PRKD20.42914249
117MAPK70.42549014
118PRKCI0.41213488
119NEK20.39514975
120BRSK20.38025976
121STK30.37801573
122WNK10.37782328
123MAP3K130.37587279
124SGK30.37506935
125RPS6KA20.37045400
126ROCK10.37013530
127INSRR0.36937851
128RPS6KA60.35623562
129PRKAA20.35541130
130CDK90.35441039
131JAK10.35161165
132GRK10.34847198
133PRKAA10.34748323
134ROCK20.34271212
135PRKG20.34250196
136PIK3CA0.33606212
137JAK20.33357800
138IGF1R0.33332901
139CSNK1A1L0.33260926
140CHUK0.32290748
141MAP3K60.31784076
142YES10.30150950
143HIPK20.28329415
144DMPK0.27557949

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.40221780
2Glycosaminoglycan degradation_Homo sapiens_hsa005311.92130728
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82439894
4Maturity onset diabetes of the young_Homo sapiens_hsa049501.77870012
5Tryptophan metabolism_Homo sapiens_hsa003801.71997140
6Fatty acid degradation_Homo sapiens_hsa000711.67297341
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65002017
8Thyroid cancer_Homo sapiens_hsa052161.64578728
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61506928
10Fatty acid metabolism_Homo sapiens_hsa012121.60654187
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58053472
12Butanoate metabolism_Homo sapiens_hsa006501.55187272
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53494195
14Hippo signaling pathway_Homo sapiens_hsa043901.49868699
15Bile secretion_Homo sapiens_hsa049761.47742861
16Sulfur metabolism_Homo sapiens_hsa009201.43111744
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38281776
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37665061
19ECM-receptor interaction_Homo sapiens_hsa045121.32853554
20Bladder cancer_Homo sapiens_hsa052191.32566644
21PPAR signaling pathway_Homo sapiens_hsa033201.32072446
22Arginine biosynthesis_Homo sapiens_hsa002201.31964237
23Lysosome_Homo sapiens_hsa041421.31411792
24Lysine degradation_Homo sapiens_hsa003101.30724055
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30061235
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29253515
27Basal cell carcinoma_Homo sapiens_hsa052171.27198565
28Fat digestion and absorption_Homo sapiens_hsa049751.27073225
29Vitamin digestion and absorption_Homo sapiens_hsa049771.26459210
30Adherens junction_Homo sapiens_hsa045201.24575480
31Sphingolipid metabolism_Homo sapiens_hsa006001.21790098
32Protein digestion and absorption_Homo sapiens_hsa049741.21083298
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20800146
34Propanoate metabolism_Homo sapiens_hsa006401.17576476
35Phenylalanine metabolism_Homo sapiens_hsa003601.14495952
36Proteoglycans in cancer_Homo sapiens_hsa052051.11886889
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10878305
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10819549
39Dorso-ventral axis formation_Homo sapiens_hsa043201.09112686
40Focal adhesion_Homo sapiens_hsa045101.08185924
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07364242
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06011765
43Notch signaling pathway_Homo sapiens_hsa043301.02488107
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01818789
45Chronic myeloid leukemia_Homo sapiens_hsa052201.01282108
46Mineral absorption_Homo sapiens_hsa049781.00956408
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99508297
48Endometrial cancer_Homo sapiens_hsa052130.97391033
49Hedgehog signaling pathway_Homo sapiens_hsa043400.97374391
50Caffeine metabolism_Homo sapiens_hsa002320.96495495
51N-Glycan biosynthesis_Homo sapiens_hsa005100.96432689
52Tight junction_Homo sapiens_hsa045300.96255369
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96212679
54Amoebiasis_Homo sapiens_hsa051460.92360006
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.91302344
56Small cell lung cancer_Homo sapiens_hsa052220.91187860
57Insulin signaling pathway_Homo sapiens_hsa049100.88405357
58Starch and sucrose metabolism_Homo sapiens_hsa005000.87782454
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.87759393
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86061031
61Thyroid hormone synthesis_Homo sapiens_hsa049180.85940110
62Carbon metabolism_Homo sapiens_hsa012000.85213662
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.84648953
64Retinol metabolism_Homo sapiens_hsa008300.83142078
65Pyruvate metabolism_Homo sapiens_hsa006200.82942678
66Selenocompound metabolism_Homo sapiens_hsa004500.82439832
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82068908
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81015461
69Tyrosine metabolism_Homo sapiens_hsa003500.80799425
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79509142
71Insulin resistance_Homo sapiens_hsa049310.79150236
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77787362
73One carbon pool by folate_Homo sapiens_hsa006700.77472662
74Prion diseases_Homo sapiens_hsa050200.76596904
75Histidine metabolism_Homo sapiens_hsa003400.75707292
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75703043
77Melanoma_Homo sapiens_hsa052180.74856921
78Peroxisome_Homo sapiens_hsa041460.74066387
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73899444
80MicroRNAs in cancer_Homo sapiens_hsa052060.73124531
81Choline metabolism in cancer_Homo sapiens_hsa052310.72843238
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72290148
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71882983
84beta-Alanine metabolism_Homo sapiens_hsa004100.71583345
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71434587
86Chemical carcinogenesis_Homo sapiens_hsa052040.70740369
87AMPK signaling pathway_Homo sapiens_hsa041520.70637393
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70593577
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69095768
90Pancreatic cancer_Homo sapiens_hsa052120.67477239
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66970035
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66888462
93Axon guidance_Homo sapiens_hsa043600.66210602
94Renal cell carcinoma_Homo sapiens_hsa052110.66182728
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65330826
96Other glycan degradation_Homo sapiens_hsa005110.64894905
97Pathways in cancer_Homo sapiens_hsa052000.64526649
98Renin-angiotensin system_Homo sapiens_hsa046140.63637249
99Biosynthesis of amino acids_Homo sapiens_hsa012300.63597459
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63566398
101Glioma_Homo sapiens_hsa052140.62738106
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62365429
103Inositol phosphate metabolism_Homo sapiens_hsa005620.61969698
104Non-small cell lung cancer_Homo sapiens_hsa052230.61617970
105Prolactin signaling pathway_Homo sapiens_hsa049170.61512178
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61456487
107Estrogen signaling pathway_Homo sapiens_hsa049150.60509058
108Glutathione metabolism_Homo sapiens_hsa004800.59990321
109Pentose phosphate pathway_Homo sapiens_hsa000300.59786040
110Fatty acid biosynthesis_Homo sapiens_hsa000610.58815514
111Melanogenesis_Homo sapiens_hsa049160.57980680
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.56378283
113Glucagon signaling pathway_Homo sapiens_hsa049220.56156447
114Galactose metabolism_Homo sapiens_hsa000520.56029558
115mTOR signaling pathway_Homo sapiens_hsa041500.55852005
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55574594
117Complement and coagulation cascades_Homo sapiens_hsa046100.53849049
118Vibrio cholerae infection_Homo sapiens_hsa051100.53768630
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52523974
120Arginine and proline metabolism_Homo sapiens_hsa003300.51563953
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51072522
122ABC transporters_Homo sapiens_hsa020100.47468797
123Glycerolipid metabolism_Homo sapiens_hsa005610.46460014
124TGF-beta signaling pathway_Homo sapiens_hsa043500.46420138
125Prostate cancer_Homo sapiens_hsa052150.46316490
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44821898

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