ERICH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)9.28059946
2urate metabolic process (GO:0046415)8.79593792
3drug transport (GO:0015893)8.21115332
4lipoprotein transport (GO:0042953)7.81367477
5aminoglycoside antibiotic metabolic process (GO:0030647)7.77194270
6drug catabolic process (GO:0042737)7.71106280
7lysine metabolic process (GO:0006553)7.13840971
8lysine catabolic process (GO:0006554)7.13840971
9organic cation transport (GO:0015695)7.02252917
10very-low-density lipoprotein particle assembly (GO:0034379)6.92019431
11regulation of triglyceride catabolic process (GO:0010896)6.86942126
12phosphate ion transport (GO:0006817)6.62078112
13plasma lipoprotein particle assembly (GO:0034377)6.59011105
14exogenous drug catabolic process (GO:0042738)6.58027613
15regulation of guanylate cyclase activity (GO:0031282)6.26575975
16epoxygenase P450 pathway (GO:0019373)6.18869617
17phospholipid efflux (GO:0033700)6.16537464
18cysteine metabolic process (GO:0006534)6.01664567
19protein-lipid complex assembly (GO:0065005)5.95035931
20intestinal absorption (GO:0050892)5.81400832
21high-density lipoprotein particle remodeling (GO:0034375)5.75158003
22modified amino acid transport (GO:0072337)5.68840104
23fat-soluble vitamin biosynthetic process (GO:0042362)5.67632985
24quaternary ammonium group transport (GO:0015697)5.67319839
25phosphate ion transmembrane transport (GO:0035435)5.61885640
26angiotensin maturation (GO:0002003)5.59436713
27nonribosomal peptide biosynthetic process (GO:0019184)5.55506073
28glyoxylate metabolic process (GO:0046487)5.55275522
29regulation of cholesterol esterification (GO:0010872)5.54709512
30renal absorption (GO:0070293)5.18880646
31glutathione biosynthetic process (GO:0006750)5.14047698
32excretion (GO:0007588)5.04392466
33peptide catabolic process (GO:0043171)5.00473029
34reverse cholesterol transport (GO:0043691)4.94947639
35tricarboxylic acid metabolic process (GO:0072350)4.87601021
36positive regulation of guanylate cyclase activity (GO:0031284)4.80414765
37aspartate family amino acid catabolic process (GO:0009068)4.78827268
38endocrine process (GO:0050886)4.76240449
39regulation of systemic arterial blood pressure by hormone (GO:0001990)4.76240449
40regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.76240449
41response to mercury ion (GO:0046689)4.74438362
42oligosaccharide catabolic process (GO:0009313)4.73914725
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72759259
44vitamin D metabolic process (GO:0042359)4.70427850
45protein-lipid complex remodeling (GO:0034368)4.67314313
46macromolecular complex remodeling (GO:0034367)4.67314313
47plasma lipoprotein particle remodeling (GO:0034369)4.67314313
48NADH metabolic process (GO:0006734)4.65427161
49flavonoid metabolic process (GO:0009812)4.65245012
50intestinal cholesterol absorption (GO:0030299)4.59181634
51response to phenylpropanoid (GO:0080184)4.56955088
52cholesterol efflux (GO:0033344)4.56594155
53positive regulation of lipoprotein lipase activity (GO:0051006)4.55713586
54positive regulation of triglyceride lipase activity (GO:0061365)4.55713586
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.53223563
56homocysteine metabolic process (GO:0050667)4.52077706
57short-chain fatty acid metabolic process (GO:0046459)4.50295677
58phosphate ion homeostasis (GO:0055062)4.49733450
59trivalent inorganic anion homeostasis (GO:0072506)4.49733450
60fructose metabolic process (GO:0006000)4.49363329
61lipoprotein metabolic process (GO:0042157)4.47160630
62bile acid and bile salt transport (GO:0015721)4.42612419
63toxin transport (GO:1901998)4.38089275
64plasma lipoprotein particle organization (GO:0071827)4.31055204
65carnitine transport (GO:0015879)4.27277907
66amino-acid betaine transport (GO:0015838)4.27277907
67regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.23389636
68regulation of systemic arterial blood pressure (GO:0003073)4.23348717
69peptide biosynthetic process (GO:0043043)4.22580120
70proline metabolic process (GO:0006560)4.16596843
71protein-lipid complex subunit organization (GO:0071825)4.09975164
72cellular modified amino acid catabolic process (GO:0042219)4.04137638
73cellular glucuronidation (GO:0052695)4.04094762
74regulation of cGMP biosynthetic process (GO:0030826)4.03418194
75uronic acid metabolic process (GO:0006063)4.01120795
76glucuronate metabolic process (GO:0019585)4.01120795
77urea cycle (GO:0000050)3.99764089
78branched-chain amino acid metabolic process (GO:0009081)3.98235358
79amino-acid betaine metabolic process (GO:0006577)3.95288862
80glutamine family amino acid biosynthetic process (GO:0009084)3.94809854
81cellular response to nitric oxide (GO:0071732)3.93714025
82peptide hormone processing (GO:0016486)3.93441288
83sulfur compound transport (GO:0072348)3.93400402
84receptor guanylyl cyclase signaling pathway (GO:0007168)3.91338187
85drinking behavior (GO:0042756)3.90956219
86fatty acid beta-oxidation (GO:0006635)3.88851565
87L-phenylalanine metabolic process (GO:0006558)3.88266812
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.88266812
89serine family amino acid metabolic process (GO:0009069)3.86549812
90drug metabolic process (GO:0017144)3.84900264
91urea metabolic process (GO:0019627)3.84501558
92polyol transport (GO:0015791)3.81001480
93regulation of cellular extravasation (GO:0002691)3.80716902
94digestion (GO:0007586)3.79242893
95aromatic amino acid family catabolic process (GO:0009074)3.77097577
96sterol homeostasis (GO:0055092)3.76815409
97indole-containing compound catabolic process (GO:0042436)3.76484883
98indolalkylamine catabolic process (GO:0046218)3.76484883
99tryptophan catabolic process (GO:0006569)3.76484883
1002-oxoglutarate metabolic process (GO:0006103)3.75994312
101beta-amyloid metabolic process (GO:0050435)3.75296289
102serine family amino acid catabolic process (GO:0009071)3.75128319
103vitamin transmembrane transport (GO:0035461)3.74883621
104metanephric nephron tubule development (GO:0072234)3.73516411
105metanephric tubule development (GO:0072170)3.73516411
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72948364
107L-phenylalanine catabolic process (GO:0006559)3.72948364
108positive regulation of lipid catabolic process (GO:0050996)3.71951763
109glutathione metabolic process (GO:0006749)3.71586749
110cholesterol homeostasis (GO:0042632)3.71431337
111vitamin transport (GO:0051180)3.71266620
112carnitine metabolic process (GO:0009437)3.67908387
113glutathione derivative metabolic process (GO:1901685)3.67178678
114glutathione derivative biosynthetic process (GO:1901687)3.67178678
115glycoside metabolic process (GO:0016137)3.64020440
116hormone catabolic process (GO:0042447)3.61750798
117L-ascorbic acid metabolic process (GO:0019852)3.60187553
118valine metabolic process (GO:0006573)3.60155158
119nitrogen cycle metabolic process (GO:0071941)3.59574988
120tryptophan metabolic process (GO:0006568)3.59096223
121adhesion of symbiont to host (GO:0044406)3.58157746
122fatty acid oxidation (GO:0019395)3.57292841
123actin filament depolymerization (GO:0030042)3.54747240
124fat-soluble vitamin metabolic process (GO:0006775)3.53696010
125renal system process involved in regulation of blood volume (GO:0001977)3.53642008
126glutamate metabolic process (GO:0006536)3.52105605
127regulation of lipoprotein metabolic process (GO:0050746)3.50058124
128lipid oxidation (GO:0034440)3.50007813
129adhesion of symbiont to host cell (GO:0044650)3.48291023
130virion attachment to host cell (GO:0019062)3.48291023
131transepithelial transport (GO:0070633)3.48126740
132cellular carbohydrate catabolic process (GO:0044275)3.46140021
133alditol metabolic process (GO:0019400)3.43758826
134tricarboxylic acid cycle (GO:0006099)3.43748311
135positive regulation of glycoprotein biosynthetic process (GO:0010560)3.42345853
136negative regulation of cholesterol transport (GO:0032375)3.41990183
137negative regulation of sterol transport (GO:0032372)3.41990183
138glycerol metabolic process (GO:0006071)3.41848007
139metanephric nephron epithelium development (GO:0072243)3.41211195
140response to nitric oxide (GO:0071731)3.39827444
141serine family amino acid biosynthetic process (GO:0009070)3.38680747
142regulation of bile acid biosynthetic process (GO:0070857)3.37353112
143cellular ketone body metabolic process (GO:0046950)3.36360425
144fatty acid catabolic process (GO:0009062)3.36005625
145acetyl-CoA metabolic process (GO:0006084)3.34608862
146cellular response to reactive nitrogen species (GO:1902170)3.34266299
147regulation of cholesterol homeostasis (GO:2000188)3.32889103
148regulation of cGMP metabolic process (GO:0030823)3.32419057
149purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.26548555
1503-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.26548555
151maintenance of gastrointestinal epithelium (GO:0030277)3.25849715
152pyrimidine ribonucleoside catabolic process (GO:0046133)3.25679255
153hydrogen peroxide catabolic process (GO:0042744)3.24628270
154vitamin biosynthetic process (GO:0009110)3.23180445
155glycolipid catabolic process (GO:0019377)3.19984275
156sulfate transmembrane transport (GO:1902358)3.19356517
157glycosylceramide metabolic process (GO:0006677)3.19255670
158positive regulation of fatty acid biosynthetic process (GO:0045723)3.16498692
159digestive system process (GO:0022600)3.15975067
160glucose 6-phosphate metabolic process (GO:0051156)3.14701494
161glycosphingolipid catabolic process (GO:0046479)3.14595677
162branched-chain amino acid catabolic process (GO:0009083)3.14171608
163alkaloid metabolic process (GO:0009820)3.13970590
164positive regulation of triglyceride metabolic process (GO:0090208)3.12787592
165positive regulation of glycoprotein metabolic process (GO:1903020)3.12175293
166diacylglycerol metabolic process (GO:0046339)3.11134415
167sexual reproduction (GO:0019953)3.10907069
168vitamin A metabolic process (GO:0006776)3.10675430
169regulation of vitamin metabolic process (GO:0030656)3.09700083
170bile acid metabolic process (GO:0008206)3.02234949
171positive regulation of cGMP biosynthetic process (GO:0030828)3.01699799
172nucleoside diphosphate biosynthetic process (GO:0009133)3.01476221
173low-density lipoprotein particle remodeling (GO:0034374)3.01168858
174mRNA modification (GO:0016556)3.00446678
175cobalamin metabolic process (GO:0009235)3.00133305
176arginine metabolic process (GO:0006525)2.99887200
177leukotriene metabolic process (GO:0006691)2.99870352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.78330889
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.70103061
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.35729901
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.97445479
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.95784016
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.81391736
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.77335024
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.61224516
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.99914075
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.78233376
11GATA1_22025678_ChIP-Seq_K562_Human2.71972339
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.61678977
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.56335659
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.54354448
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47702072
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.39393928
17GATA4_25053715_ChIP-Seq_YYC3_Human2.36248919
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.15462988
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.10057313
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.09736800
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07765215
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.02936776
23NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.99073522
24GATA6_25053715_ChIP-Seq_YYC3_Human1.96217424
25AR_21909140_ChIP-Seq_LNCAP_Human1.88200104
26CLOCK_20551151_ChIP-Seq_293T_Human1.88057823
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78760045
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.78720868
29HNF4A_19822575_ChIP-Seq_HepG2_Human1.78074288
30PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.75798818
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75422976
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72370329
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69977852
34SOX2_20726797_ChIP-Seq_SW620_Human1.69751615
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69226153
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.56571260
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56267676
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54348907
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53850384
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.48231610
41RACK7_27058665_Chip-Seq_MCF-7_Human1.43785459
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42466507
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39011059
44VDR_22108803_ChIP-Seq_LS180_Human1.38847704
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.36211652
46LXR_22292898_ChIP-Seq_THP-1_Human1.35481069
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30647662
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22509790
49EGR1_19032775_ChIP-ChIP_M12_Human1.20855452
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19977884
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17462686
52SMAD3_21741376_ChIP-Seq_HESCs_Human1.16391656
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15304778
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13794360
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12651080
56JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11628822
57SA1_27219007_Chip-Seq_Bcells_Human1.09349392
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08180015
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.06247823
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05660935
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04800899
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04677996
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04440139
64GATA2_19941826_ChIP-Seq_K562_Human1.04434951
65FOXA1_25552417_ChIP-Seq_VCAP_Human1.03119110
66GATA1_19941826_ChIP-Seq_K562_Human1.01765226
67BCOR_27268052_Chip-Seq_Bcells_Human1.01068476
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01012550
69CEBPB_22108803_ChIP-Seq_LS180_Human1.00882207
70BCL6_27268052_Chip-Seq_Bcells_Human1.00846901
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00758138
72NANOG_20526341_ChIP-Seq_ESCs_Human1.00677093
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99703374
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99665964
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96127596
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96020125
77ATF3_27146783_Chip-Seq_COLON_Human0.95106443
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95041863
79RUNX1_27514584_Chip-Seq_MCF-7_Human0.94878960
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94703970
81SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93964329
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93011054
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92736594
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92129372
85DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90662138
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89851885
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88949522
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88487125
89CREB1_26743006_Chip-Seq_LNCaP_Human0.88474247
90HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87603820
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87222432
92MYC_19915707_ChIP-ChIP_AK7_Human0.86460729
93SOX2_22085726_ChIP-Seq_NPCs_Mouse0.85740941
94BCAT_22108803_ChIP-Seq_LS180_Human0.84608994
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83859245
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83557285
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82985108
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82776838
99CDX2_22108803_ChIP-Seq_LS180_Human0.81675351
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81630725
101TP63_23658742_ChIP-Seq_EP156T_Human0.81205864
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80686472
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80453792
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79546499
105TAF2_19829295_ChIP-Seq_ESCs_Human0.79271237
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78598716
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78444753
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77862278
109FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77248868
110CTCF_27219007_Chip-Seq_Bcells_Human0.77173832
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.76787372
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76430582
113KLF5_25053715_ChIP-Seq_YYC3_Human0.76030362
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75367747
115NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74011939
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73901015
117CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.73873608
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.73733282
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.73733282
120DROSHA_22980978_ChIP-Seq_HELA_Human0.73319978
121KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72779698
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72215534
123P68_20966046_ChIP-Seq_HELA_Human0.72161208
124TP63_22573176_ChIP-Seq_HFKS_Human0.71710216
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71442559
126RXR_22108803_ChIP-Seq_LS180_Human0.71045214
127CTCF_20526341_ChIP-Seq_ESCs_Human0.69900175
128VDR_24787735_ChIP-Seq_THP-1_Human0.69763818
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69389359
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69162789
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69093975
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.68746055
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.68656127
134TCF4_18268006_ChIP-ChIP_LS174T_Human0.68399902
135TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67601795
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66475293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.90537792
2MP0002139_abnormal_hepatobiliary_system5.31882804
3MP0004043_abnormal_pH_regulation5.21855695
4MP0004019_abnormal_vitamin_homeostasis4.56789388
5MP0005332_abnormal_amino_acid4.16915410
6MP0008875_abnormal_xenobiotic_pharmacok3.43064014
7MP0001666_abnormal_nutrient_absorption3.38438412
8MP0009643_abnormal_urine_homeostasis3.31784893
9MP0003252_abnormal_bile_duct3.03631364
10MP0001765_abnormal_ion_homeostasis3.02040453
11MP0005085_abnormal_gallbladder_physiolo2.92926549
12MP0009379_abnormal_foot_pigmentation2.81198374
13MP0005377_hearing/vestibular/ear_phenot2.76879994
14MP0003878_abnormal_ear_physiology2.76879994
15MP0002138_abnormal_hepatobiliary_system2.71477474
16MP0005636_abnormal_mineral_homeostasis2.54458143
17MP0003195_calcinosis2.50103307
18MP0005365_abnormal_bile_salt2.42720852
19MP0002136_abnormal_kidney_physiology2.37465378
20MP0001756_abnormal_urination2.34021378
21MP0004264_abnormal_extraembryonic_tissu2.00473665
22MP0005409_darkened_coat_color2.00038109
23MP0005084_abnormal_gallbladder_morpholo1.98953295
24MP0009840_abnormal_foam_cell1.97869948
25MP0004270_analgesia1.93467989
26MP0000538_abnormal_urinary_bladder1.87308232
27MP0010234_abnormal_vibrissa_follicle1.78689020
28MP0004147_increased_porphyrin_level1.73192383
29MP0010329_abnormal_lipoprotein_level1.70364495
30MP0003868_abnormal_feces_composition1.60151843
31MP0003183_abnormal_peptide_metabolism1.59572615
32MP0001958_emphysema1.57332462
33MP0002876_abnormal_thyroid_physiology1.49486715
34MP0003718_maternal_effect1.47450262
35MP0003806_abnormal_nucleotide_metabolis1.47210751
36MP0005058_abnormal_lysosome_morphology1.45242350
37MP0005584_abnormal_enzyme/coenzyme_acti1.41671487
38MP0003300_gastrointestinal_ulcer1.31250357
39MP0008961_abnormal_basal_metabolism1.29380279
40MP0002089_abnormal_postnatal_growth/wei1.29092655
41MP0005319_abnormal_enzyme/_coenzyme1.28627891
42MP0003191_abnormal_cellular_cholesterol1.27926230
43MP0010352_gastrointestinal_tract_polyps1.27630972
44MP0004782_abnormal_surfactant_physiolog1.24843093
45MP0004885_abnormal_endolymph1.24534908
46MP0005451_abnormal_body_composition1.17510323
47MP0001764_abnormal_homeostasis1.15204128
48MP0001188_hyperpigmentation1.14170143
49MP0000490_abnormal_crypts_of1.12351196
50MP0002118_abnormal_lipid_homeostasis1.10282350
51MP0003186_abnormal_redox_activity1.10161299
52MP0001501_abnormal_sleep_pattern1.04808495
53MP0003866_abnormal_defecation1.04688979
54MP0006036_abnormal_mitochondrial_physio1.02088444
55MP0000230_abnormal_systemic_arterial0.99478236
56MP0002796_impaired_skin_barrier0.96921168
57MP0003283_abnormal_digestive_organ0.87747484
58MP0000609_abnormal_liver_physiology0.87162873
59MP0003638_abnormal_response/metabolism_0.85870393
60MP0000462_abnormal_digestive_system0.85850296
61MP0004858_abnormal_nervous_system0.84386132
62MP0001663_abnormal_digestive_system0.83987794
63MP0005535_abnormal_body_temperature0.82944487
64MP0009115_abnormal_fat_cell0.82260492
65MP0002135_abnormal_kidney_morphology0.79877278
66MP0009642_abnormal_blood_homeostasis0.78303402
67MP0001664_abnormal_digestion0.78240796
68MP0003879_abnormal_hair_cell0.77965548
69MP0006138_congestive_heart_failure0.76713882
70MP0000249_abnormal_blood_vessel0.75299206
71MP0005381_digestive/alimentary_phenotyp0.74189219
72MP0005666_abnormal_adipose_tissue0.68706854
73MP0002928_abnormal_bile_duct0.67016817
74MP0005501_abnormal_skin_physiology0.66887753
75MP0002896_abnormal_bone_mineralization0.65410673
76MP0001845_abnormal_inflammatory_respons0.63382580
77MP0003705_abnormal_hypodermis_morpholog0.62092391
78MP0009764_decreased_sensitivity_to0.60518733
79MP0005334_abnormal_fat_pad0.60497004
80MP0002822_catalepsy0.58963679
81MP0009780_abnormal_chondrocyte_physiolo0.58744521
82MP0002168_other_aberrant_phenotype0.58233847
83MP0002098_abnormal_vibrissa_morphology0.56274340
84MP0008260_abnormal_autophagy0.55989725
85MP0004484_altered_response_of0.54927997
86MP0000678_abnormal_parathyroid_gland0.54260585
87MP0005083_abnormal_biliary_tract0.52972357
88MP0000477_abnormal_intestine_morphology0.51856513
89MP0001485_abnormal_pinna_reflex0.51593735
90MP0003724_increased_susceptibility_to0.51491537
91MP0000598_abnormal_liver_morphology0.51422125
92MP0005167_abnormal_blood-brain_barrier0.51152386
93MP0008469_abnormal_protein_level0.50853453
94MP0002078_abnormal_glucose_homeostasis0.50349747
95MP0000537_abnormal_urethra_morphology0.48762216
96MP0006082_CNS_inflammation0.48206774
97MP0005395_other_phenotype0.45860581
98MP0005448_abnormal_energy_balance0.45572616
99MP0010155_abnormal_intestine_physiology0.45430101
100MP0005266_abnormal_metabolism0.45276001
101MP0005670_abnormal_white_adipose0.45103867
102MP0003646_muscle_fatigue0.45096948
103MP0003953_abnormal_hormone_level0.44504113
104MP0000566_synostosis0.44345772
105MP0008872_abnormal_physiological_respon0.44318079
106MP0005376_homeostasis/metabolism_phenot0.43418381
107MP0009785_altered_susceptibility_to0.41763695
108MP0006054_spinal_hemorrhage0.40843109
109MP0003329_amyloid_beta_deposits0.39731994
110MP0000371_diluted_coat_color0.39249207
111MP0005166_decreased_susceptibility_to0.38058382
112MP0003959_abnormal_lean_body0.37835093
113MP0009765_abnormal_xenobiotic_induced0.37768202
114MP0001873_stomach_inflammation0.37477405
115MP0002734_abnormal_mechanical_nocicepti0.36578563
116MP0006035_abnormal_mitochondrial_morpho0.36563560
117MP0003315_abnormal_perineum_morphology0.36302875
118MP0010386_abnormal_urinary_bladder0.36302278
119MP0005165_increased_susceptibility_to0.36286191
120MP0005408_hypopigmentation0.35419457
121MP0002069_abnormal_eating/drinking_beha0.35117000
122MP0005375_adipose_tissue_phenotype0.35040426
123MP0005330_cardiomyopathy0.34051056
124MP0002971_abnormal_brown_adipose0.33537309
125MP0000427_abnormal_hair_cycle0.32335817
126MP0005025_abnormal_response_to0.32326142
127MP0000747_muscle_weakness0.32273109
128MP0005645_abnormal_hypothalamus_physiol0.31635400
129MP0002396_abnormal_hematopoietic_system0.31417420
130MP0000604_amyloidosis0.31041899

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.39020577
2Metabolic alkalosis (HP:0200114)6.36401121
3Gout (HP:0001997)6.27586186
4Abnormality of glutamine family amino acid metabolism (HP:0010902)6.14294653
5Hyperactive renin-angiotensin system (HP:0000841)6.05199927
6Hypokalemic alkalosis (HP:0001949)6.00582960
7Hypomagnesemia (HP:0002917)5.77093109
8Abnormality of chloride homeostasis (HP:0011422)5.63465956
9Abnormal urine output (HP:0012590)5.58993711
10Polyuria (HP:0000103)5.51882173
11Abnormality of renal excretion (HP:0011036)5.33085924
12Proximal tubulopathy (HP:0000114)5.28433648
13Abnormality of magnesium homeostasis (HP:0004921)5.17016981
14Hyperglycinuria (HP:0003108)5.16930768
15Hyperuricemia (HP:0002149)4.80980688
16Increased purine levels (HP:0004368)4.80980688
17Abnormality of purine metabolism (HP:0004352)4.72830531
18Pigmentary retinal degeneration (HP:0001146)4.61284933
19Chronic diarrhea (HP:0002028)4.53600833
20Abnormal drinking behavior (HP:0030082)4.38084277
21Polydipsia (HP:0001959)4.38084277
22Abnormality of urine glucose concentration (HP:0011016)4.21062953
23Glycosuria (HP:0003076)4.21062953
24Hypolipoproteinemia (HP:0010981)4.19886269
25Alkalosis (HP:0001948)4.16131032
26Abnormality of glycine metabolism (HP:0010895)4.13792584
27Abnormality of serine family amino acid metabolism (HP:0010894)4.13792584
28Hydroxyprolinuria (HP:0003080)4.13394639
29Abnormality of proline metabolism (HP:0010907)4.13394639
30Abnormality of renin-angiotensin system (HP:0000847)4.10877534
31Hyperaldosteronism (HP:0000859)4.00050571
32Tetany (HP:0001281)3.97559822
33Generalized aminoaciduria (HP:0002909)3.87802952
34Hypercalciuria (HP:0002150)3.86456038
35Renal salt wasting (HP:0000127)3.83977090
36Systemic lupus erythematosus (HP:0002725)3.80515985
37Abnormality of vitamin metabolism (HP:0100508)3.69888942
38Ketoacidosis (HP:0001993)3.69183201
39Hyperphosphaturia (HP:0003109)3.58763942
40Malnutrition (HP:0004395)3.57956519
41Abnormality of nucleobase metabolism (HP:0010932)3.53257306
42Abnormality of monocarboxylic acid metabolism (HP:0010996)3.42642076
43Posterior subcapsular cataract (HP:0007787)3.35530766
44Congenital sensorineural hearing impairment (HP:0008527)3.32305541
45Abnormal urine phosphate concentration (HP:0012599)3.30457625
46Nephrolithiasis (HP:0000787)3.29309338
47Renal tubular acidosis (HP:0001947)3.28428534
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.25050838
49Abnormality of aspartate family amino acid metabolism (HP:0010899)3.19418540
50Widely patent fontanelles and sutures (HP:0004492)3.17489025
51Hypokalemia (HP:0002900)3.14598491
52Ketosis (HP:0001946)3.12264826
53Delayed epiphyseal ossification (HP:0002663)3.05382944
54Ileus (HP:0002595)2.97538134
55Dehydration (HP:0001944)2.93625748
56Steatorrhea (HP:0002570)2.89155848
57Hyperlipoproteinemia (HP:0010980)2.88192233
58Hypophosphatemia (HP:0002148)2.84681385
59Abnormality of fatty-acid metabolism (HP:0004359)2.78044182
60Metabolic acidosis (HP:0001942)2.74840346
61Subcapsular cataract (HP:0000523)2.70913617
62Confusion (HP:0001289)2.69102703
63Epidermoid cyst (HP:0200040)2.67678036
64Hyperammonemia (HP:0001987)2.63895697
65Abnormality of pyrimidine metabolism (HP:0004353)2.63318147
66Abnormality of potassium homeostasis (HP:0011042)2.61280554
67Vascular calcification (HP:0004934)2.59989390
68Nephrocalcinosis (HP:0000121)2.59752012
69Potter facies (HP:0002009)2.55242663
70Facial shape deformation (HP:0011334)2.55242663
71Decreased circulating renin level (HP:0003351)2.52336244
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.49779580
73Metaphyseal cupping (HP:0003021)2.44780844
74Hemorrhage of the eye (HP:0011885)2.44540075
75Hyperglycinemia (HP:0002154)2.43752119
76Rickets (HP:0002748)2.42736027
77Abdominal distention (HP:0003270)2.42553397
78Delayed CNS myelination (HP:0002188)2.39912424
79Autoimmune thrombocytopenia (HP:0001973)2.39105518
80Poikilocytosis (HP:0004447)2.38695353
81Dicarboxylic aciduria (HP:0003215)2.37844970
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37844970
83Enlarged epiphyses (HP:0010580)2.36784874
84Vacuolated lymphocytes (HP:0001922)2.33685416
85Vomiting (HP:0002013)2.31316391
86Cardiovascular calcification (HP:0011915)2.30214905
87Abnormality of the vitamin B12 metabolism (HP:0004341)2.29789604
88Thin bony cortex (HP:0002753)2.24198316
89Focal segmental glomerulosclerosis (HP:0000097)2.23539465
90Nausea (HP:0002018)2.22738728
91Abnormal tarsal ossification (HP:0008369)2.21017257
92Sensorimotor neuropathy (HP:0007141)2.20823189
93Xanthomatosis (HP:0000991)2.18063461
94Abnormal glucose tolerance (HP:0001952)2.15358549
95Abnormal enzyme/coenzyme activity (HP:0012379)2.12669814
96Abnormality of vitamin B metabolism (HP:0004340)2.12606535
97Pancreatitis (HP:0001733)2.09466854
98Lethargy (HP:0001254)2.07872433
99Renal tubular dysfunction (HP:0000124)2.06393462
100Abnormality of alkaline phosphatase activity (HP:0004379)2.06259509
101Hyponatremia (HP:0002902)2.04582705
102Abnormality of sodium homeostasis (HP:0010931)2.04087437
103Complement deficiency (HP:0004431)2.02832583
104Hyperphosphatemia (HP:0002905)2.02133932
105Glomerulonephritis (HP:0000099)1.99974444
106Methylmalonic aciduria (HP:0012120)1.99658183
107Hyperparathyroidism (HP:0000843)1.98707042
108Segmental peripheral demyelination/remyelination (HP:0003481)1.96855528
109Eczematoid dermatitis (HP:0000976)1.96494765
110Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94320809
111Enlarged kidneys (HP:0000105)1.91679890
112Abnormality of renal resorption (HP:0011038)1.89909197
113Adrenal overactivity (HP:0002717)1.89818297
114Wide cranial sutures (HP:0010537)1.89368104
115Abnormality of complement system (HP:0005339)1.87176590
116Cerebral palsy (HP:0100021)1.86132610
117Hypobetalipoproteinemia (HP:0003563)1.85788266
118Villous atrophy (HP:0011473)1.84825728
119Abnormality of small intestinal villus morphology (HP:0011472)1.84825728
120Fat malabsorption (HP:0002630)1.83582859
121Late onset (HP:0003584)1.81588641
122Irritability (HP:0000737)1.81417588
123Conjugated hyperbilirubinemia (HP:0002908)1.80478480
124Amyloidosis (HP:0011034)1.78558262
125Gastrointestinal dysmotility (HP:0002579)1.78520268
126Hypophosphatemic rickets (HP:0004912)1.78473151
127Megaloblastic anemia (HP:0001889)1.77633474
128Bilateral sensorineural hearing impairment (HP:0008619)1.76535456
129Growth hormone excess (HP:0000845)1.75026319
130Hypotension (HP:0002615)1.74884264
131Acanthocytosis (HP:0001927)1.72826372
132Abnormality of the costochondral junction (HP:0000919)1.71356638
133Abnormality of carpal bone ossification (HP:0006257)1.70575365
134Nephritis (HP:0000123)1.70567952
135Peripheral demyelination (HP:0011096)1.70491595
136Glomerulosclerosis (HP:0000096)1.70326873
137White forelock (HP:0002211)1.69561840
138Chondrocalcinosis (HP:0000934)1.69121196
139Protuberant abdomen (HP:0001538)1.67523684
140Intrahepatic cholestasis (HP:0001406)1.67111043
141Abnormality of macrophages (HP:0004311)1.63888375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.02581630
2ACVR1B7.82361957
3WNK36.64695756
4OXSR16.37455477
5STK393.73542733
6PIK3CG3.64372352
7MST43.40753617
8MUSK2.97748065
9MST1R2.69384392
10FRK2.63393626
11BCKDK2.58306389
12GRK62.27632711
13STK38L2.24939998
14PDK42.12056074
15PDK32.12056074
16NEK12.09758425
17MAP4K22.03546461
18TNIK1.93838726
19PDK21.68848192
20WNK11.64848351
21LMTK21.59781643
22SGK4941.49086549
23SGK2231.49086549
24NME11.48873767
25EPHA31.33165416
26GRK11.25695083
27PRKG21.20694608
28MAP3K121.19470792
29CDC42BPA1.18645611
30STK241.17727043
31RIPK11.17467318
32EPHA41.16500948
33ERN11.15685158
34PTK61.14728851
35STK381.08646475
36TYK21.08251266
37LRRK21.03088872
38FGFR31.03063884
39NLK1.01618900
40MAP3K20.99154392
41MAP4K10.99099505
42EPHB10.96355505
43PIK3CA0.95045127
44SGK30.87826675
45FGFR40.85837614
46STK100.85362044
47MET0.84965814
48MAP3K70.84881188
49PTK20.82532386
50EPHA20.82047788
51PRKCI0.79215028
52MAP3K100.78580354
53MAP2K20.76359598
54MAP3K30.73603626
55GSK3A0.71699425
56PAK40.71593254
57AKT30.71140608
58SGK20.67030651
59CASK0.66410171
60DYRK1B0.65858761
61PDGFRA0.64004458
62DMPK0.63486783
63MAPK110.61124840
64PRKAA20.60858353
65PDPK10.60794354
66PINK10.59585224
67EPHB20.58256249
68FER0.58255256
69PRKAA10.57499204
70RET0.54396463
71IRAK10.54277433
72MYLK0.53356494
73PRPF4B0.49690121
74CSF1R0.47964730
75CAMK2D0.46881026
76BMX0.46822471
77MAP3K110.45934330
78SGK10.43290161
79CAMK2G0.42481019
80PAK30.41551921
81LATS10.39576931
82ITK0.39133489
83CAMK2B0.38828061
84TAOK10.38796123
85PDK10.37579137
86MAP2K60.35782816
87ABL20.35253545
88ERBB40.34799788
89TESK20.34551804
90CAMK2A0.34036311
91TESK10.33399390
92SCYL20.31806728
93RPS6KA20.31273751
94IRAK30.31124131
95FYN0.30314063
96PRKCZ0.30201238
97PRKCD0.29031140
98DDR20.28813793
99KIT0.27983576
100TTK0.27784214
101MAP3K80.27199746
102STK110.27034955
103INSRR0.26123514
104MATK0.25820054
105ICK0.25172271
106SYK0.25084150
107KDR0.25056748
108AKT20.24903840
109PIM20.24310765
110PRKACG0.24309197
111LCK0.24024390
112PRKCA0.23855201
113CDK190.23535802
114NEK60.23241794
115GRK50.23235565
116OBSCN0.22989515
117TAOK30.22967552
118ADRBK20.22065865
119TIE10.21273980
120NUAK10.16925311
121MAP2K10.16647363
122TRIB30.16457657
123KSR20.16005260
124PTK2B0.15798093
125TGFBR20.14116678
126PIM10.12885652
127ERBB20.12699235
128ROCK10.12445869
129TBK10.11915455
130SRC0.11851167
131MAPK150.11115935
132PRKCQ0.10532490
133RIPK40.10433708
134CSK0.10273199
135PRKD20.09760663
136MAP3K140.09468401
137JAK20.09430229
138MAP3K10.08931427
139PRKACA0.08502251
140CSNK1A10.07505370
141MAP2K40.06646908
142INSR0.05126801

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.58449565
2Vitamin digestion and absorption_Homo sapiens_hsa049773.32239990
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.19004079
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08024739
5Butanoate metabolism_Homo sapiens_hsa006502.94766700
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66610387
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61702824
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.58695313
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51382092
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.46596645
11Mineral absorption_Homo sapiens_hsa049782.44458359
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43159973
13Renin-angiotensin system_Homo sapiens_hsa046142.37626619
14Fat digestion and absorption_Homo sapiens_hsa049752.36196819
15Propanoate metabolism_Homo sapiens_hsa006402.30979954
16Pyruvate metabolism_Homo sapiens_hsa006202.19979383
17Tryptophan metabolism_Homo sapiens_hsa003802.12991294
18Fatty acid degradation_Homo sapiens_hsa000712.10831544
19Peroxisome_Homo sapiens_hsa041462.05496363
20Linoleic acid metabolism_Homo sapiens_hsa005912.05452787
21Sulfur metabolism_Homo sapiens_hsa009201.99595033
22Bile secretion_Homo sapiens_hsa049761.99246741
23Starch and sucrose metabolism_Homo sapiens_hsa005001.88325154
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79383448
25Protein digestion and absorption_Homo sapiens_hsa049741.78376236
26Glutathione metabolism_Homo sapiens_hsa004801.76567338
27beta-Alanine metabolism_Homo sapiens_hsa004101.65772067
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.63306412
29Carbon metabolism_Homo sapiens_hsa012001.57615553
30Folate biosynthesis_Homo sapiens_hsa007901.51618063
31Collecting duct acid secretion_Homo sapiens_hsa049661.51515736
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50521653
33Arginine and proline metabolism_Homo sapiens_hsa003301.49059232
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46454659
35Histidine metabolism_Homo sapiens_hsa003401.43394011
36Fatty acid metabolism_Homo sapiens_hsa012121.43286039
37Fructose and mannose metabolism_Homo sapiens_hsa000511.42348598
38PPAR signaling pathway_Homo sapiens_hsa033201.41227178
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39887222
40Arginine biosynthesis_Homo sapiens_hsa002201.38781589
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29511537
42Ether lipid metabolism_Homo sapiens_hsa005651.25528968
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24184107
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23955482
45Galactose metabolism_Homo sapiens_hsa000521.23178814
46Glycerolipid metabolism_Homo sapiens_hsa005611.20886207
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.15265674
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14338911
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07100353
50Nitrogen metabolism_Homo sapiens_hsa009101.06063449
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05745426
52Lysine degradation_Homo sapiens_hsa003101.01215772
53Caffeine metabolism_Homo sapiens_hsa002320.94400430
54Biosynthesis of amino acids_Homo sapiens_hsa012300.94267632
55Selenocompound metabolism_Homo sapiens_hsa004500.91205397
56Other glycan degradation_Homo sapiens_hsa005110.88389132
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86476935
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.82225928
59Fatty acid biosynthesis_Homo sapiens_hsa000610.77164910
60Phenylalanine metabolism_Homo sapiens_hsa003600.73781207
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.72309984
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70321152
63Pentose phosphate pathway_Homo sapiens_hsa000300.69274584
64Asthma_Homo sapiens_hsa053100.64681398
65Thyroid hormone synthesis_Homo sapiens_hsa049180.64380663
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63101844
67Chemical carcinogenesis_Homo sapiens_hsa052040.61876353
68Sphingolipid metabolism_Homo sapiens_hsa006000.59068471
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58135436
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.57009544
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.55534846
72Oxidative phosphorylation_Homo sapiens_hsa001900.52795205
73Metabolic pathways_Homo sapiens_hsa011000.51745920
74Staphylococcus aureus infection_Homo sapiens_hsa051500.50220150
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.49500619
76Retinol metabolism_Homo sapiens_hsa008300.49047676
77Complement and coagulation cascades_Homo sapiens_hsa046100.46488706
78Fatty acid elongation_Homo sapiens_hsa000620.45549590
79ABC transporters_Homo sapiens_hsa020100.42951332
80Arachidonic acid metabolism_Homo sapiens_hsa005900.42632786
81Renin secretion_Homo sapiens_hsa049240.42266721
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38576865
83Gastric acid secretion_Homo sapiens_hsa049710.37635934
84Allograft rejection_Homo sapiens_hsa053300.36295526
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.33853721
86Steroid biosynthesis_Homo sapiens_hsa001000.33252602
87Graft-versus-host disease_Homo sapiens_hsa053320.32821053
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32455566
89Autoimmune thyroid disease_Homo sapiens_hsa053200.32085835
90Vibrio cholerae infection_Homo sapiens_hsa051100.27793399
91Glucagon signaling pathway_Homo sapiens_hsa049220.27412517
92Parkinsons disease_Homo sapiens_hsa050120.27248705
93Lysosome_Homo sapiens_hsa041420.25853848
94Cocaine addiction_Homo sapiens_hsa050300.24837827
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22570963
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17170661
97Tyrosine metabolism_Homo sapiens_hsa003500.17130478
98Type I diabetes mellitus_Homo sapiens_hsa049400.16037892
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.14719572
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14530413
101GnRH signaling pathway_Homo sapiens_hsa049120.14205939
102Sulfur relay system_Homo sapiens_hsa041220.12989157
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12030861
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11242193
105Choline metabolism in cancer_Homo sapiens_hsa052310.10342331
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10263413
107Alzheimers disease_Homo sapiens_hsa050100.08240868
108Insulin secretion_Homo sapiens_hsa049110.07813463
109Tight junction_Homo sapiens_hsa045300.07392230
110AMPK signaling pathway_Homo sapiens_hsa041520.06478941
111Pertussis_Homo sapiens_hsa051330.05894880
112Amphetamine addiction_Homo sapiens_hsa050310.05631122
113Synaptic vesicle cycle_Homo sapiens_hsa047210.05260114
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.05065270
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.04812918
116African trypanosomiasis_Homo sapiens_hsa051430.04639274
117Ovarian steroidogenesis_Homo sapiens_hsa049130.04458959
118Inositol phosphate metabolism_Homo sapiens_hsa005620.04365005
119Insulin resistance_Homo sapiens_hsa049310.04361442
120Salivary secretion_Homo sapiens_hsa049700.03777144
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.02874970
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02363001
123Hepatitis C_Homo sapiens_hsa05160-0.0207378
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0136477
125Bladder cancer_Homo sapiens_hsa05219-0.0074573
126Cardiac muscle contraction_Homo sapiens_hsa04260-0.0073051
127Pancreatic secretion_Homo sapiens_hsa04972-0.0033180

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