ERF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polarized epithelial cell differentiation (GO:0030859)5.16855588
2establishment of apical/basal cell polarity (GO:0035089)5.15622174
3regulation of gene silencing by RNA (GO:0060966)4.85006771
4regulation of posttranscriptional gene silencing (GO:0060147)4.85006771
5regulation of gene silencing by miRNA (GO:0060964)4.85006771
6axon ensheathment in central nervous system (GO:0032291)4.64065240
7central nervous system myelination (GO:0022010)4.64065240
8lateral sprouting from an epithelium (GO:0060601)4.43340194
9establishment of monopolar cell polarity (GO:0061162)4.16334453
10establishment or maintenance of monopolar cell polarity (GO:0061339)4.16334453
11apoptotic process involved in morphogenesis (GO:0060561)4.03590731
12regulation of hippo signaling (GO:0035330)4.02304824
13axon ensheathment (GO:0008366)3.97268101
14ensheathment of neurons (GO:0007272)3.97268101
15myelination (GO:0042552)3.84213044
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.84199186
17paraxial mesoderm development (GO:0048339)3.68494230
18negative regulation of erythrocyte differentiation (GO:0045647)3.64866290
19COPI coating of Golgi vesicle (GO:0048205)3.61799096
20Golgi transport vesicle coating (GO:0048200)3.61799096
21regulation of early endosome to late endosome transport (GO:2000641)3.52111723
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.50396235
23atrioventricular valve morphogenesis (GO:0003181)3.48177792
24anterior/posterior axis specification, embryo (GO:0008595)3.47579576
25activation of Rac GTPase activity (GO:0032863)3.46097131
26regulation of mammary gland epithelial cell proliferation (GO:0033599)3.41884042
27negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.41847730
28positive regulation of SMAD protein import into nucleus (GO:0060391)3.41760151
29apical protein localization (GO:0045176)3.38791121
30protein localization to endosome (GO:0036010)3.37578231
31semaphorin-plexin signaling pathway (GO:0071526)3.36504737
32cytoskeletal anchoring at plasma membrane (GO:0007016)3.33413350
33protein retention in ER lumen (GO:0006621)3.33127950
34bone trabecula formation (GO:0060346)3.33112729
35basement membrane organization (GO:0071711)3.30896484
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.25205706
37establishment or maintenance of apical/basal cell polarity (GO:0035088)3.24510705
38establishment or maintenance of bipolar cell polarity (GO:0061245)3.24510705
39myelination in peripheral nervous system (GO:0022011)3.23175785
40peripheral nervous system axon ensheathment (GO:0032292)3.23175785
41hemidesmosome assembly (GO:0031581)3.22666345
42asymmetric protein localization (GO:0008105)3.20664619
43regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.19731806
44establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.19576658
45negative regulation of fatty acid transport (GO:2000192)3.18588193
46desmosome organization (GO:0002934)3.17363049
47negative regulation of cell size (GO:0045792)3.17078178
48regulation of extracellular matrix disassembly (GO:0010715)3.16448688
49embryonic process involved in female pregnancy (GO:0060136)3.14971051
50regulation of translational fidelity (GO:0006450)3.14162001
51regulation of SMAD protein import into nucleus (GO:0060390)3.09881464
52adherens junction assembly (GO:0034333)3.08650231
53mannose metabolic process (GO:0006013)3.07987897
54establishment of epithelial cell polarity (GO:0090162)3.06840621
55cranial suture morphogenesis (GO:0060363)3.06409821
56branching involved in mammary gland duct morphogenesis (GO:0060444)3.04902499
57regulation of glucose import in response to insulin stimulus (GO:2001273)3.02545101
58apoptotic process involved in development (GO:1902742)3.01994144
59regulation of cholesterol homeostasis (GO:2000188)2.95434118
60negative regulation of catenin import into nucleus (GO:0035414)2.93740166
61proline biosynthetic process (GO:0006561)2.92371092
62positive regulation of blood vessel endothelial cell migration (GO:0043536)2.89934865
63protein heterotrimerization (GO:0070208)2.86982212
64embryonic camera-type eye development (GO:0031076)2.85669052
65regulation of catenin import into nucleus (GO:0035412)2.85327066
66pinocytosis (GO:0006907)2.84433189
673-UTR-mediated mRNA stabilization (GO:0070935)2.84364951
68modulation by symbiont of host cellular process (GO:0044068)2.83893070
69endothelial cell chemotaxis (GO:0035767)2.83864395
70hippo signaling (GO:0035329)2.83614426
71branching involved in salivary gland morphogenesis (GO:0060445)2.83588882
72craniofacial suture morphogenesis (GO:0097094)2.83163193
73epithelial cell-cell adhesion (GO:0090136)2.82072413
74anatomical structure regression (GO:0060033)2.81423416
75cell-substrate junction assembly (GO:0007044)2.81394182
76Leydig cell differentiation (GO:0033327)2.80711019
77regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.80304605
78Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80001455
79skin morphogenesis (GO:0043589)2.77936313
80cell fate commitment involved in formation of primary germ layer (GO:0060795)2.76721505
81non-canonical Wnt signaling pathway (GO:0035567)2.75483961
82positive regulation of Cdc42 GTPase activity (GO:0043089)2.75022743
83cochlea morphogenesis (GO:0090103)2.74344627
84trophectodermal cell differentiation (GO:0001829)2.74241671
85modulation by virus of host process (GO:0019054)2.74135892
86regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.73775957
87retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73601473
88vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.70895028
89astrocyte development (GO:0014002)2.70643130
90heterochromatin organization (GO:0070828)2.68890755
91cell-substrate adherens junction assembly (GO:0007045)2.68493225
92focal adhesion assembly (GO:0048041)2.68493225
93regulation of NFAT protein import into nucleus (GO:0051532)2.68232872
94cell migration involved in sprouting angiogenesis (GO:0002042)2.67822161
95collecting duct development (GO:0072044)2.67721180
96positive regulation of catenin import into nucleus (GO:0035413)2.67299661
97epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67148380
98pentose-phosphate shunt (GO:0006098)2.66670901
99positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.65531169
100convergent extension (GO:0060026)2.65303392
101renal filtration (GO:0097205)2.65164857
102response to laminar fluid shear stress (GO:0034616)2.65127409
103cell-cell junction maintenance (GO:0045217)2.65124935
104regulation of establishment of planar polarity (GO:0090175)2.63956081
105cell surface receptor signaling pathway involved in heart development (GO:0061311)2.63911970
106barbed-end actin filament capping (GO:0051016)2.63704635
107maternal placenta development (GO:0001893)2.63451547
108positive regulation of histone deacetylation (GO:0031065)2.62171289
109negative regulation of chondrocyte differentiation (GO:0032331)2.61653454
110notochord development (GO:0030903)2.60761292
111positive regulation of extracellular matrix organization (GO:1903055)2.58833736
112embryonic placenta development (GO:0001892)2.58709328
113modulation by virus of host morphology or physiology (GO:0019048)2.58624912
114cellular response to epidermal growth factor stimulus (GO:0071364)2.58087634
115mesenchymal cell proliferation (GO:0010463)2.57845240
116negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57754040
117regulation of extracellular matrix organization (GO:1903053)2.57588033
118activation of MAPKKK activity (GO:0000185)2.56742150
119labyrinthine layer blood vessel development (GO:0060716)2.56717502
120regulation of chromatin binding (GO:0035561)2.56594635
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.55765902
122endocardial cushion development (GO:0003197)2.54837416
123glucose catabolic process (GO:0006007)2.54040199
124pre-miRNA processing (GO:0031054)2.53356216
125axis elongation (GO:0003401)2.52870804
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52409080
127regulation of apoptotic process involved in morphogenesis (GO:1902337)2.52321862
128positive regulation of receptor recycling (GO:0001921)2.51874004
129establishment of tissue polarity (GO:0007164)2.51837411
130establishment of planar polarity (GO:0001736)2.51837411
131fatty acid elongation (GO:0030497)2.51488575
132head development (GO:0060322)2.51270778
133mitotic nuclear envelope reassembly (GO:0007084)2.50812106
134nuclear envelope reassembly (GO:0031468)2.50812106
135negative regulation of viral release from host cell (GO:1902187)2.49768543
136negative regulation of GTP catabolic process (GO:0033125)2.48914884
137negative regulation of GTPase activity (GO:0034260)2.48914884
138RNA stabilization (GO:0043489)2.48848620
139mRNA stabilization (GO:0048255)2.48848620
140regulation of cholesterol biosynthetic process (GO:0045540)2.48598280
141glomerular filtration (GO:0003094)2.48045412
142endothelial cell morphogenesis (GO:0001886)2.46298627
143lung-associated mesenchyme development (GO:0060484)2.46102082
144regulation of histone H3-K27 methylation (GO:0061085)2.45428834
145intracellular estrogen receptor signaling pathway (GO:0030520)2.45176114
146neural tube closure (GO:0001843)2.44272091
147myelin maintenance (GO:0043217)2.44097327
148insulin-like growth factor receptor signaling pathway (GO:0048009)2.43224054
149tube closure (GO:0060606)2.42777645
150stress fiber assembly (GO:0043149)2.42023563
151negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.41466925
152positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.41130912
153positive regulation of nuclease activity (GO:0032075)2.40317544
154actin filament bundle assembly (GO:0051017)2.39047977
155actin filament bundle organization (GO:0061572)2.39047977
156positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.36919342
157embryonic eye morphogenesis (GO:0048048)2.36608565
158cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.36208178
159blood vessel endothelial cell migration (GO:0043534)2.35348988
160positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.31336971
161cellular response to virus (GO:0098586)2.29466150
162UV protection (GO:0009650)2.24644806
163regulation of nucleobase-containing compound transport (GO:0032239)2.23984344
164positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.22180302
165protein targeting to plasma membrane (GO:0072661)2.22005070
166regulation of ARF GTPase activity (GO:0032312)2.21828548
167regulation of fatty acid beta-oxidation (GO:0031998)2.21040665
168glucose 6-phosphate metabolic process (GO:0051156)2.20998183
169cell junction maintenance (GO:0034331)2.19981360
170proline metabolic process (GO:0006560)2.19521856
171embryo implantation (GO:0007566)2.18295389
172Rho protein signal transduction (GO:0007266)2.17827156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.67776209
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.67776209
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.67776209
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.57206619
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.08623891
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.89744997
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.86594594
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.69038489
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.67247263
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.63242080
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.52599980
12ZNF263_19887448_ChIP-Seq_K562_Human2.44432161
13TCF3_18692474_ChIP-Seq_MEFs_Mouse2.40561980
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.39192467
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.26702156
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.17111045
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14697668
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13802373
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.11711996
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.11057525
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09167084
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.07980151
23* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.06485746
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03565505
25* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.90468609
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90192107
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85941501
28* KDM2B_26808549_Chip-Seq_DND41_Human1.85739023
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85497365
30* ELK3_25401928_ChIP-Seq_HUVEC_Human1.84789276
31NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.83367724
32RACK7_27058665_Chip-Seq_MCF-7_Human1.77869017
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.74637257
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73252677
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.73126875
36POU5F1_16518401_ChIP-PET_MESCs_Mouse1.72757499
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72699185
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70127325
39KDM2B_26808549_Chip-Seq_K562_Human1.66545230
40LXR_22292898_ChIP-Seq_THP-1_Human1.61062376
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.60393139
42* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57709652
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57548178
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54302602
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51811460
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51314432
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50154463
48VDR_24763502_ChIP-Seq_THP-1_Human1.48703139
49P68_20966046_ChIP-Seq_HELA_Human1.48186989
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.46444176
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.45807072
52TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.42608920
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.40875943
54TP53_22127205_ChIP-Seq_IMR90_Human1.40712532
55* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40605674
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40157508
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37691632
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36628141
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36077295
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35881789
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35081187
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.34403907
63CLOCK_20551151_ChIP-Seq_293T_Human1.34092149
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32692358
65SMC4_20622854_ChIP-Seq_HELA_Human1.32194765
66SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31392625
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31221533
68MAF_26560356_Chip-Seq_TH1_Human1.31187846
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30679781
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30457651
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.29654105
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29336132
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28132454
74* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.27978912
75SOX2_18692474_ChIP-Seq_MESCs_Mouse1.27022123
76PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.26900167
77* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.26825794
78NCOR1_26117541_ChIP-Seq_K562_Human1.26817176
79* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26672291
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26442480
81CREB1_26743006_Chip-Seq_LNCaP_Human1.25999026
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25325679
83ATF3_27146783_Chip-Seq_COLON_Human1.24555495
84* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23213842
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23114015
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.22945452
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.21808180
88MYC_22102868_ChIP-Seq_BL_Human1.20967674
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20440338
90* TCF7_22412390_ChIP-Seq_EML_Mouse1.20204008
91VDR_21846776_ChIP-Seq_THP-1_Human1.19041914
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18691673
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18475090
94MAF_26560356_Chip-Seq_TH2_Human1.16072401
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15136634
96* UTX_26944678_Chip-Seq_JUKART_Human1.14673826
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.14231206
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13762761
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13493788
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13136897
101OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12452059
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12268764
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09474237
104ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08952168
105* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08895085
106EGR1_19374776_ChIP-ChIP_THP-1_Human1.08842509
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08820734
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08794173
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07666617
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07399109
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07323493
112* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06456623
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06326043
114PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06213275
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.05427864
116RUNX1_27514584_Chip-Seq_MCF-7_Human1.05168577
117* ISL1_27105846_Chip-Seq_CPCs_Mouse1.04555069
118POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04051916
119* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02973107
120GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00454634
121RXR_22158963_ChIP-Seq_LIVER_Mouse1.00375427
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99970474
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99572677
124SA1_27219007_Chip-Seq_ERYTHROID_Human0.99419554
125HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98749118
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98634028
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97688430
128* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97435337
129* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97132060
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96565411
131BCOR_27268052_Chip-Seq_Bcells_Human0.95444809
132* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94754466
133P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94498504
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.94468824
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93864240
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93661228
137NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93103275
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92746116
139* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92012136
140SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91913157
141SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91727728
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.91697531
143TP53_23651856_ChIP-Seq_MEFs_Mouse0.91330013
144CTCF_27219007_Chip-Seq_Bcells_Human0.90513135
145CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90359768
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90257332
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.90163167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.55161158
2MP0005623_abnormal_meninges_morphology3.31203623
3MP0010030_abnormal_orbit_morphology3.10411309
4MP0004272_abnormal_basement_membrane2.83723499
5MP0008438_abnormal_cutaneous_collagen2.78995952
6MP0005451_abnormal_body_composition2.46254266
7MP0005409_darkened_coat_color2.41454357
8MP0002877_abnormal_melanocyte_morpholog2.38425970
9MP0009053_abnormal_anal_canal2.27797324
10MP0005058_abnormal_lysosome_morphology2.24283843
11MP0002249_abnormal_larynx_morphology2.06267444
12MP0000467_abnormal_esophagus_morphology2.06166679
13MP0000762_abnormal_tongue_morphology2.05978234
14MP0004185_abnormal_adipocyte_glucose2.05402078
15MP0002653_abnormal_ependyma_morphology2.04509987
16MP0000537_abnormal_urethra_morphology1.96129322
17MP0003941_abnormal_skin_development1.95907255
18MP0008260_abnormal_autophagy1.92373798
19MP0003136_yellow_coat_color1.88385024
20MP0000678_abnormal_parathyroid_gland1.86085522
21MP0002796_impaired_skin_barrier1.85883629
22MP0003283_abnormal_digestive_organ1.83840975
23MP0003566_abnormal_cell_adhesion1.82374792
24MP0003385_abnormal_body_wall1.77740746
25MP0002089_abnormal_postnatal_growth/wei1.67652601
26MP0003937_abnormal_limbs/digits/tail_de1.66657321
27MP0000733_abnormal_muscle_development1.66480881
28MP0005275_abnormal_skin_tensile1.66384294
29MP0005076_abnormal_cell_differentiation1.64477639
30MP0003950_abnormal_plasma_membrane1.62406648
31MP0003172_abnormal_lysosome_physiology1.61420529
32MP0003453_abnormal_keratinocyte_physiol1.61068401
33MP0010352_gastrointestinal_tract_polyps1.59913932
34MP0003191_abnormal_cellular_cholesterol1.59541980
35MP0003119_abnormal_digestive_system1.58482548
36MP0010678_abnormal_skin_adnexa1.57854689
37MP0000462_abnormal_digestive_system1.57038832
38MP0001849_ear_inflammation1.55932383
39MP0002084_abnormal_developmental_patter1.53104614
40MP0003300_gastrointestinal_ulcer1.51879203
41MP0002697_abnormal_eye_size1.51078172
42MP0002282_abnormal_trachea_morphology1.47947908
43MP0003755_abnormal_palate_morphology1.46300788
44MP0004197_abnormal_fetal_growth/weight/1.46151969
45MP0002111_abnormal_tail_morphology1.45568275
46MP0000858_altered_metastatic_potential1.45459600
47MP0004133_heterotaxia1.45370908
48* MP0002085_abnormal_embryonic_tissue1.45115982
49MP0000920_abnormal_myelination1.42626494
50MP0000428_abnormal_craniofacial_morphol1.42489123
51MP0000534_abnormal_ureter_morphology1.41598079
52MP0005508_abnormal_skeleton_morphology1.40301059
53MP0002092_abnormal_eye_morphology1.39528838
54MP0009278_abnormal_bone_marrow1.37906668
55MP0001340_abnormal_eyelid_morphology1.37709465
56MP0000767_abnormal_smooth_muscle1.35278070
57MP0003436_decreased_susceptibility_to1.35226138
58MP0000383_abnormal_hair_follicle1.34742188
59MP0000003_abnormal_adipose_tissue1.33205789
60MP0004233_abnormal_muscle_weight1.33096928
61MP0002932_abnormal_joint_morphology1.32830922
62MP0005023_abnormal_wound_healing1.32634777
63MP0001346_abnormal_lacrimal_gland1.30155711
64MP0005501_abnormal_skin_physiology1.28851195
65MP0004381_abnormal_hair_follicle1.28642071
66MP0003303_peritoneal_inflammation1.27900319
67MP0001293_anophthalmia1.27014448
68MP0004885_abnormal_endolymph1.26582748
69MP0004947_skin_inflammation1.26052697
70MP0000049_abnormal_middle_ear1.25925704
71MP0000432_abnormal_head_morphology1.23751673
72MP0004264_abnormal_extraembryonic_tissu1.23319548
73MP0001348_abnormal_lacrimal_gland1.21966309
74MP0009250_abnormal_appendicular_skeleto1.20785188
75MP0002060_abnormal_skin_morphology1.20706424
76MP0003115_abnormal_respiratory_system1.20351144
77MP0010234_abnormal_vibrissa_follicle1.20057058
78MP0003935_abnormal_craniofacial_develop1.19396030
79MP0005248_abnormal_Harderian_gland1.17527014
80MP0003942_abnormal_urinary_system1.17142759
81MP0005257_abnormal_intraocular_pressure1.14875775
82MP0002086_abnormal_extraembryonic_tissu1.14077675
83MP0003938_abnormal_ear_development1.13118615
84MP0010368_abnormal_lymphatic_system1.12096329
85MP0003329_amyloid_beta_deposits1.12045377
86MP0003091_abnormal_cell_migration1.11813014
87MP0001730_embryonic_growth_arrest1.11463322
88MP0000579_abnormal_nail_morphology1.09340493
89MP0002116_abnormal_craniofacial_bone1.08511667
90MP0009384_cardiac_valve_regurgitation1.08368929
91MP0004858_abnormal_nervous_system1.08274464
92MP0005380_embryogenesis_phenotype1.07886113
93MP0001672_abnormal_embryogenesis/_devel1.07886113
94MP0001216_abnormal_epidermal_layer1.07013267
95* MP0002925_abnormal_cardiovascular_devel1.02619400
96MP0002998_abnormal_bone_remodeling1.02180707
97MP0008057_abnormal_DNA_replication1.01484354
98MP0002098_abnormal_vibrissa_morphology1.01189107
99* MP0003861_abnormal_nervous_system0.99707053
100MP0009333_abnormal_splenocyte_physiolog0.99196825
101MP0005503_abnormal_tendon_morphology0.98034542
102MP0000377_abnormal_hair_follicle0.96752973
103MP0010630_abnormal_cardiac_muscle0.96126918
104MP0002896_abnormal_bone_mineralization0.95529928
105MP0003279_aneurysm0.95473105
106MP0002396_abnormal_hematopoietic_system0.95109916
107MP0003984_embryonic_growth_retardation0.94886783
108MP0002088_abnormal_embryonic_growth/wei0.94785861
109MP0002108_abnormal_muscle_morphology0.94645834
110MP0009931_abnormal_skin_appearance0.93633493
111MP0005621_abnormal_cell_physiology0.93167735
112MP0005360_urolithiasis0.91220012
113* MP0001697_abnormal_embryo_size0.90731051
114MP0000751_myopathy0.90606093
115MP0001915_intracranial_hemorrhage0.90413940
116MP0002254_reproductive_system_inflammat0.90252162
117MP0004134_abnormal_chest_morphology0.90249435
118MP0000566_synostosis0.89760405
119MP0002114_abnormal_axial_skeleton0.89179957
120MP0009672_abnormal_birth_weight0.89165967
121MP0006138_congestive_heart_failure0.87791722
122MP0002233_abnormal_nose_morphology0.86654341
123MP0005666_abnormal_adipose_tissue0.85736995
124MP0000647_abnormal_sebaceous_gland0.85462877
125MP0001286_abnormal_eye_development0.85392899
126MP0005375_adipose_tissue_phenotype0.84696219
127MP0001958_emphysema0.84165332
128MP0004808_abnormal_hematopoietic_stem0.83819657
129MP0003634_abnormal_glial_cell0.83304344
130MP0000350_abnormal_cell_proliferation0.83156018
131MP0001243_abnormal_dermal_layer0.82319053
132MP0001485_abnormal_pinna_reflex0.81526005
133MP0004957_abnormal_blastocyst_morpholog0.81424422
134MP0000747_muscle_weakness0.78937460
135MP0009840_abnormal_foam_cell0.78623066
136MP0004510_myositis0.78356620
137MP0001784_abnormal_fluid_regulation0.77762492
138MP0005390_skeleton_phenotype0.77042377
139MP0003828_pulmonary_edema0.76487606
140* MP0001614_abnormal_blood_vessel0.73214923
141MP0000759_abnormal_skeletal_muscle0.71593892
142MP0002080_prenatal_lethality0.71204541
143MP0005670_abnormal_white_adipose0.71079670
144MP0000750_abnormal_muscle_regeneration0.70334203
145MP0004087_abnormal_muscle_fiber0.69027287
146MP0010771_integument_phenotype0.68025014
147MP0002113_abnormal_skeleton_development0.65921720
148MP0001533_abnormal_skeleton_physiology0.65791849
149MP0002970_abnormal_white_adipose0.63170453

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.54476356
2Shallow orbits (HP:0000586)3.80204676
3Protrusio acetabuli (HP:0003179)3.65049165
4Hyperacusis (HP:0010780)3.51556659
5Coronal craniosynostosis (HP:0004440)3.34061786
6Esophageal atresia (HP:0002032)3.08751782
7Cerebral aneurysm (HP:0004944)3.06782473
8Obstructive sleep apnea (HP:0002870)3.03685653
9Broad face (HP:0000283)3.02126597
10Rib fusion (HP:0000902)2.97588866
11Achilles tendon contracture (HP:0001771)2.89309489
12Ulnar bowing (HP:0003031)2.86466032
13Turricephaly (HP:0000262)2.76533781
14Abnormality of the Achilles tendon (HP:0005109)2.75000865
15Vertebral compression fractures (HP:0002953)2.74944617
16Cervical subluxation (HP:0003308)2.70099845
17Atrophic scars (HP:0001075)2.69519303
18Thin bony cortex (HP:0002753)2.55181288
19Supernumerary ribs (HP:0005815)2.53716570
20Pseudobulbar signs (HP:0002200)2.52926969
21Concave nail (HP:0001598)2.45372163
22Asymmetry of the thorax (HP:0001555)2.41748702
23Deep venous thrombosis (HP:0002625)2.40853800
24Flat acetabular roof (HP:0003180)2.38855293
25Ependymoma (HP:0002888)2.32495474
26Bronchomalacia (HP:0002780)2.32392185
27Sensory axonal neuropathy (HP:0003390)2.31361003
28Mitral regurgitation (HP:0001653)2.28641788
29Hemorrhage of the eye (HP:0011885)2.28484440
30Long palpebral fissure (HP:0000637)2.28255940
31Vertebral fusion (HP:0002948)2.28011092
32Vertebral clefting (HP:0008428)2.27838642
33Cerebral inclusion bodies (HP:0100314)2.25801878
34Fused cervical vertebrae (HP:0002949)2.24438962
35Ankle contracture (HP:0006466)2.23256566
36Distal lower limb muscle weakness (HP:0009053)2.23119861
37Biconcave vertebral bodies (HP:0004586)2.22895620
38Increased connective tissue (HP:0009025)2.22217533
39Neoplasm of the oral cavity (HP:0100649)2.21786672
40Supernumerary bones of the axial skeleton (HP:0009144)2.20770363
41Mitral valve prolapse (HP:0001634)2.20669277
42Short humerus (HP:0005792)2.18701408
43Partial duplication of the phalanx of hand (HP:0009999)2.18408909
44Hypoplastic ischia (HP:0003175)2.18263528
45Bladder diverticulum (HP:0000015)2.18120318
46Genu recurvatum (HP:0002816)2.17407631
47Distal upper limb amyotrophy (HP:0007149)2.15408661
48Upper limb amyotrophy (HP:0009129)2.15408661
49Large earlobe (HP:0009748)2.15097045
50Alacrima (HP:0000522)2.14121572
51Milia (HP:0001056)2.12253090
52Degeneration of the lateral corticospinal tracts (HP:0002314)2.10668783
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10668783
54Aplasia/hypoplasia of the humerus (HP:0006507)2.10033518
55Hyporeflexia of lower limbs (HP:0002600)2.09960658
56Advanced eruption of teeth (HP:0006288)2.05502294
57Premature skin wrinkling (HP:0100678)2.05418274
58Stridor (HP:0010307)2.05259661
59Astrocytoma (HP:0009592)2.04689317
60Abnormality of the astrocytes (HP:0100707)2.04689317
61Fragile skin (HP:0001030)2.04330269
62Insomnia (HP:0100785)2.03390568
63Peritonitis (HP:0002586)2.02702759
64Abnormality of the salivary glands (HP:0010286)2.02284339
65Broad metatarsal (HP:0001783)2.01762244
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00909714
67Natal tooth (HP:0000695)2.00191959
68Distal lower limb amyotrophy (HP:0008944)1.98853406
69Aneurysm (HP:0002617)1.95868110
70Abnormality of the distal phalanges of the toes (HP:0010182)1.94486073
71Blue sclerae (HP:0000592)1.93409419
72Arterial tortuosity (HP:0005116)1.92308191
73Dislocated radial head (HP:0003083)1.91951854
74Short nail (HP:0001799)1.91809516
75Selective tooth agenesis (HP:0001592)1.91760655
76Disproportionate tall stature (HP:0001519)1.91024361
77Partial duplication of thumb phalanx (HP:0009944)1.91018309
78Preaxial foot polydactyly (HP:0001841)1.91008789
79Abnormality of the labia minora (HP:0012880)1.90134922
80Wide anterior fontanel (HP:0000260)1.88962512
81Thin ribs (HP:0000883)1.86682247
82Vascular tortuosity (HP:0004948)1.86547830
83Hypotrichosis (HP:0001006)1.86378394
84Aplasia involving bones of the upper limbs (HP:0009823)1.86232232
85Aplasia of the phalanges of the hand (HP:0009802)1.86232232
86Aplasia involving bones of the extremities (HP:0009825)1.86232232
87Mildly elevated creatine phosphokinase (HP:0008180)1.86204568
88Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.85989711
89Abnormality of the thoracic spine (HP:0100711)1.85833431
90Neurofibrillary tangles (HP:0002185)1.85716750
91J-shaped sella turcica (HP:0002680)1.85187257
92Wormian bones (HP:0002645)1.84102019
93Spinal cord lesions (HP:0100561)1.84001231
94Syringomyelia (HP:0003396)1.84001231
95Abnormal vertebral ossification (HP:0100569)1.83935322
96Abnormality of the ischium (HP:0003174)1.83835136
97Abnormality of the 4th metacarpal (HP:0010012)1.81491044
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81336792
99Short 4th metacarpal (HP:0010044)1.81336792
100Increased variability in muscle fiber diameter (HP:0003557)1.80560347
101Trismus (HP:0000211)1.79775766
102Dilatation of the ascending aorta (HP:0005111)1.79740609
103Abnormality of the radial head (HP:0003995)1.79686787
104Scapular winging (HP:0003691)1.78991451
105Gastrointestinal atresia (HP:0002589)1.78968881
106Renal duplication (HP:0000075)1.78359202
107Vertebral hypoplasia (HP:0008417)1.77653476
108Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77653476
109* Arnold-Chiari malformation (HP:0002308)1.76707852
110Hyperextensible skin (HP:0000974)1.76200215
111Pterygium (HP:0001059)1.75846575
112Abnormal ossification of hand bones (HP:0005921)1.75697223
113Abnormality of the antihelix (HP:0009738)1.75232870
114Abnormality of the peritoneum (HP:0002585)1.75132382
115Muscle fiber splitting (HP:0003555)1.73893052
116Elbow flexion contracture (HP:0002987)1.73799885
117Rectovaginal fistula (HP:0000143)1.73698488
118Rectal fistula (HP:0100590)1.73698488
119Hypoplastic pelvis (HP:0008839)1.72739129
120Segmental peripheral demyelination/remyelination (HP:0003481)1.72468448
121Broad thumb (HP:0011304)1.72382301
122Aortic dissection (HP:0002647)1.72197913
123Neoplasm of striated muscle (HP:0009728)1.71746617
124Ankyloglossia (HP:0010296)1.71489265
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.71004564
126Insidious onset (HP:0003587)1.70830551
127Termporal pattern (HP:0011008)1.70830551
128Difficulty climbing stairs (HP:0003551)1.70826649
129Anteriorly placed anus (HP:0001545)1.70369621
130Short phalanx of the thumb (HP:0009660)1.69975338
131Joint laxity (HP:0001388)1.69861072
132Peripheral hypomyelination (HP:0007182)1.69763427
133Fragile nails (HP:0001808)1.69357264
134Lower limb amyotrophy (HP:0007210)1.68968707
135Metaphyseal cupping (HP:0003021)1.68072890
136Bowing of the arm (HP:0006488)1.67750625
137Pointed chin (HP:0000307)1.67679810
138Relative macrocephaly (HP:0004482)1.67319520
139Neonatal short-limb short stature (HP:0008921)1.66922805
140Patellar dislocation (HP:0002999)1.66895512
141Abnormal umbilical cord blood vessels (HP:0011403)1.66434369
142Single umbilical artery (HP:0001195)1.66434369
143Abnormality of the fetal cardiovascular system (HP:0010948)1.66434369
144Coxa vara (HP:0002812)1.66193868
145Centrally nucleated skeletal muscle fibers (HP:0003687)1.65963255
146Spinal rigidity (HP:0003306)1.65906917
147Back pain (HP:0003418)1.65852893
148Bowed forearm bones (HP:0003956)1.64801321
149Hand muscle atrophy (HP:0009130)1.64704169
150Polygenic inheritance (HP:0010982)1.64240607
151Abnormality of carpal bone ossification (HP:0006257)1.62456051
152Joint stiffness (HP:0001387)1.61939751
153Cellulitis (HP:0100658)1.61923241
154Hyperparathyroidism (HP:0000843)1.61420871
155Generalized amyotrophy (HP:0003700)1.61119076
156Abnormality of oral frenula (HP:0000190)1.60393974
157Easy fatigability (HP:0003388)1.59398184
158Elfin facies (HP:0004428)1.58872359
159Abnormality of the acetabulum (HP:0003170)1.56372836
160Aortic aneurysm (HP:0004942)1.55610564
161Abnormality of skeletal muscle fiber size (HP:0012084)1.54583318
162Overriding aorta (HP:0002623)1.53520812
163Abnormality of dentin (HP:0010299)1.51178195
164Broad distal phalanx of finger (HP:0009836)1.50851526
165Abnormality of the phalanges of the hallux (HP:0010057)1.49318333
166Spinal cord compression (HP:0002176)1.49198781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.01525222
2EPHA23.76501443
3SMG13.41910406
4CDK123.28397291
5PRPF4B2.93764108
6EPHB12.61635970
7DDR22.60929605
8IRAK32.57535588
9TYRO32.37533067
10MAPK152.35653966
11MET2.30680447
12STK392.30596605
13FGFR42.14003735
14MAP3K102.10674238
15TRIB32.04854893
16BMX2.03506587
17LATS11.88523879
18PDGFRA1.77468795
19LATS21.75926654
20EEF2K1.68904642
21PKN21.60290707
22PAK21.58536793
23DMPK1.43263553
24NME21.41432690
25UHMK11.38616540
26PAK41.38586196
27FGR1.37667255
28TLK11.37080524
29TTN1.36227904
30MTOR1.32862804
31MST1R1.32388932
32MAP2K31.31396381
33RPS6KB21.26747768
34ALK1.26213323
35EPHB21.24745659
36PTK21.24708791
37TAOK21.23999675
38NTRK11.22602800
39MAP2K21.17556808
40PNCK1.16662769
41RIPK11.14089490
42CLK11.13494788
43SIK11.12692452
44TESK21.10230913
45MAP3K31.08932969
46CDC42BPA1.07867398
47CDK71.06059094
48TESK11.03962920
49OXSR10.98444823
50PTK60.97596740
51GSK3A0.93668347
52MAP3K10.93647887
53PAK60.92975400
54PRKD20.92586785
55RPS6KA20.92058886
56LMTK20.91759429
57FGFR20.91463351
58TTK0.90096466
59PDGFRB0.89551049
60PRKD30.89521802
61STK100.89208532
62WNK40.87454819
63ARAF0.87360915
64CSK0.86807545
65WNK10.86310221
66MAP3K80.85336259
67ROCK20.85123848
68IRAK20.84795777
69DYRK1B0.84240709
70MAP3K130.84154731
71SIK30.84122534
72PDPK10.81622075
73FER0.81311548
74HIPK20.80868131
75SIK20.80476386
76IRAK40.80348119
77MAP3K110.78732084
78RPS6KC10.77160788
79RPS6KL10.77160788
80MARK20.76406494
81PKN10.75605054
82CSNK1D0.73211937
83MAP4K10.71764386
84KSR20.70818238
85PRKD10.70347374
86CDK60.70189833
87ERBB40.69255133
88TSSK60.68816648
89BRD40.68363155
90ERN10.67324405
91MAP3K90.64575924
92MAPK110.63746073
93FGFR10.63745854
94BRAF0.63718130
95PRKG20.63409561
96CAMK1G0.63004379
97CSNK1A1L0.62726147
98ZAP700.59668991
99PAK10.58288654
100RET0.56542109
101TBK10.56497096
102CSNK1E0.56474912
103PAK30.56049891
104TGFBR20.55932852
105BCR0.55908804
106LRRK20.54594141
107STK30.54060425
108CAMK1D0.53074305
109CDK40.53007168
110RPS6KA60.52369583
111DAPK30.51918423
112INSR0.51484597
113CSNK1G10.50852372
114CSNK1G30.49593016
115MAP3K70.49446162
116STK380.49432637
117FGFR30.49017870
118STK110.48648496
119CDK140.48241879
120MAP3K140.47046709
121EPHA40.45400491
122ERBB20.45146379
123MOS0.44464725
124MAP3K20.44333656
125CDK150.43911320
126CHEK10.43752706
127CDK90.43240136
128MAP3K60.43204445
129MAPKAPK20.42870737
130ILK0.42537779
131* MAPK10.42285065
132CDK11A0.42138206
133TAOK10.42130257
134MELK0.41788098
135MATK0.41403413
136PTK2B0.39893770
137MAPKAPK30.39500825
138PIM20.39272107
139CDK20.37745962
140CHUK0.37611194
141GRK60.37268288
142RPS6KA10.36123597
143PRKCI0.35913124
144AKT20.35748463
145MAPK70.34688871
146KDR0.34028290
147SGK30.33264008
148JAK30.33018619
149RIPK40.32222776
150PDK10.31739079
151MAPK120.31460649

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.36760219
2Basal cell carcinoma_Homo sapiens_hsa052173.08091393
3Hedgehog signaling pathway_Homo sapiens_hsa043402.78100705
4Hippo signaling pathway_Homo sapiens_hsa043902.60633378
5ECM-receptor interaction_Homo sapiens_hsa045122.48794903
6Steroid biosynthesis_Homo sapiens_hsa001002.38626235
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.28298304
8Notch signaling pathway_Homo sapiens_hsa043302.23109049
9Other glycan degradation_Homo sapiens_hsa005112.22384546
10Tight junction_Homo sapiens_hsa045302.13342882
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06390684
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.00377727
13Bladder cancer_Homo sapiens_hsa052191.99754013
14Axon guidance_Homo sapiens_hsa043601.86216871
15Focal adhesion_Homo sapiens_hsa045101.85075035
16Adherens junction_Homo sapiens_hsa045201.78222281
17MicroRNAs in cancer_Homo sapiens_hsa052061.73333368
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.71445346
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68823367
20Proteoglycans in cancer_Homo sapiens_hsa052051.66418750
21Renal cell carcinoma_Homo sapiens_hsa052111.65659773
22Pancreatic cancer_Homo sapiens_hsa052121.64139071
23Wnt signaling pathway_Homo sapiens_hsa043101.59136206
24TGF-beta signaling pathway_Homo sapiens_hsa043501.55303144
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54675732
26Lysine degradation_Homo sapiens_hsa003101.47691209
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.46923060
28Dorso-ventral axis formation_Homo sapiens_hsa043201.44572668
29Arginine biosynthesis_Homo sapiens_hsa002201.43676566
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33861275
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.33769908
32Arginine and proline metabolism_Homo sapiens_hsa003301.33588848
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.31379947
34Small cell lung cancer_Homo sapiens_hsa052221.28087865
35Fatty acid elongation_Homo sapiens_hsa000621.27338436
36Pentose phosphate pathway_Homo sapiens_hsa000301.24299316
37Protein digestion and absorption_Homo sapiens_hsa049741.23293720
38B cell receptor signaling pathway_Homo sapiens_hsa046621.23153047
39Insulin signaling pathway_Homo sapiens_hsa049101.19679449
40Prion diseases_Homo sapiens_hsa050201.19226906
41Amoebiasis_Homo sapiens_hsa051461.16159767
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11932799
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11184389
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10781292
45Fatty acid biosynthesis_Homo sapiens_hsa000611.10653275
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08152283
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07845192
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06297079
49Fructose and mannose metabolism_Homo sapiens_hsa000511.06172982
50Pathways in cancer_Homo sapiens_hsa052001.05206005
51Melanogenesis_Homo sapiens_hsa049161.04629507
52Hepatitis B_Homo sapiens_hsa051611.00072508
53Chronic myeloid leukemia_Homo sapiens_hsa052200.99989316
54ErbB signaling pathway_Homo sapiens_hsa040120.99067829
55Rap1 signaling pathway_Homo sapiens_hsa040150.98698580
56Osteoclast differentiation_Homo sapiens_hsa043800.98165354
57VEGF signaling pathway_Homo sapiens_hsa043700.97940158
58Hepatitis C_Homo sapiens_hsa051600.95725068
59One carbon pool by folate_Homo sapiens_hsa006700.95188002
60TNF signaling pathway_Homo sapiens_hsa046680.95141120
61Apoptosis_Homo sapiens_hsa042100.94081970
62Insulin resistance_Homo sapiens_hsa049310.92899950
63GnRH signaling pathway_Homo sapiens_hsa049120.92640889
64Galactose metabolism_Homo sapiens_hsa000520.92350047
65Prostate cancer_Homo sapiens_hsa052150.91700539
66Biosynthesis of amino acids_Homo sapiens_hsa012300.90516309
67mTOR signaling pathway_Homo sapiens_hsa041500.88006426
68Prolactin signaling pathway_Homo sapiens_hsa049170.86895395
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.85863085
70Estrogen signaling pathway_Homo sapiens_hsa049150.85374914
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.84028229
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83940022
73Ether lipid metabolism_Homo sapiens_hsa005650.82955897
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82019441
75Sulfur relay system_Homo sapiens_hsa041220.81944183
76mRNA surveillance pathway_Homo sapiens_hsa030150.81892024
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81733139
78Inositol phosphate metabolism_Homo sapiens_hsa005620.81242516
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.81054958
80Toxoplasmosis_Homo sapiens_hsa051450.80815370
81Shigellosis_Homo sapiens_hsa051310.80247737
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78032499
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77911022
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77144789
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76531416
86Glioma_Homo sapiens_hsa052140.76065545
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.74107047
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73887284
89Spliceosome_Homo sapiens_hsa030400.73288722
90Dilated cardiomyopathy_Homo sapiens_hsa054140.71810146
91Choline metabolism in cancer_Homo sapiens_hsa052310.71519149
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71384872
93Gap junction_Homo sapiens_hsa045400.70143915
94Endocytosis_Homo sapiens_hsa041440.69554490
95Ras signaling pathway_Homo sapiens_hsa040140.69069603
96Bile secretion_Homo sapiens_hsa049760.68836712
97HIF-1 signaling pathway_Homo sapiens_hsa040660.68639986
98Systemic lupus erythematosus_Homo sapiens_hsa053220.67922682
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66988422
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66566806
101Influenza A_Homo sapiens_hsa051640.66457798
102Salmonella infection_Homo sapiens_hsa051320.66064449
103Melanoma_Homo sapiens_hsa052180.66016393
104Colorectal cancer_Homo sapiens_hsa052100.65704717
105T cell receptor signaling pathway_Homo sapiens_hsa046600.64052610
106AMPK signaling pathway_Homo sapiens_hsa041520.62853145
107Viral carcinogenesis_Homo sapiens_hsa052030.62102845
108Lysosome_Homo sapiens_hsa041420.62032559
109HTLV-I infection_Homo sapiens_hsa051660.60436521
110FoxO signaling pathway_Homo sapiens_hsa040680.60046377
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59635834
112MAPK signaling pathway_Homo sapiens_hsa040100.58734255
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58663094
114Fatty acid metabolism_Homo sapiens_hsa012120.56932255
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56929366
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56139869
117Thyroid cancer_Homo sapiens_hsa052160.55951291
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54166191
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.54111532
120Malaria_Homo sapiens_hsa051440.53376390
121Leishmaniasis_Homo sapiens_hsa051400.53308632
122Butanoate metabolism_Homo sapiens_hsa006500.52313972
123Histidine metabolism_Homo sapiens_hsa003400.51601770
124Complement and coagulation cascades_Homo sapiens_hsa046100.51516476
125Non-small cell lung cancer_Homo sapiens_hsa052230.51398410
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51191002
127Vibrio cholerae infection_Homo sapiens_hsa051100.50972813
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.50482390
129Glucagon signaling pathway_Homo sapiens_hsa049220.48142621
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.45071539
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45070150
132RNA transport_Homo sapiens_hsa030130.44749976
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43831094
134Viral myocarditis_Homo sapiens_hsa054160.43726236
135Endometrial cancer_Homo sapiens_hsa052130.41082746
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41049457
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40900310
138Fat digestion and absorption_Homo sapiens_hsa049750.39889372
139Acute myeloid leukemia_Homo sapiens_hsa052210.39537159
140Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39057149
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38928807
142Vitamin B6 metabolism_Homo sapiens_hsa007500.37226786

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »