ERCC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)4.54646016
2telomere maintenance via semi-conservative replication (GO:0032201)4.48912948
3DNA strand elongation involved in DNA replication (GO:0006271)4.36938075
4DNA strand elongation (GO:0022616)4.26211360
5DNA double-strand break processing (GO:0000729)4.21712002
6DNA deamination (GO:0045006)4.11607938
7prenylation (GO:0097354)4.00124554
8protein prenylation (GO:0018342)4.00124554
9telomere maintenance via recombination (GO:0000722)3.96268491
10termination of RNA polymerase III transcription (GO:0006386)3.88850758
11transcription elongation from RNA polymerase III promoter (GO:0006385)3.88850758
12rRNA modification (GO:0000154)3.87178056
13CENP-A containing nucleosome assembly (GO:0034080)3.83908045
14chromatin remodeling at centromere (GO:0031055)3.81061118
15DNA replication checkpoint (GO:0000076)3.77797257
16mitotic recombination (GO:0006312)3.74164295
17mitotic metaphase plate congression (GO:0007080)3.73773344
18non-recombinational repair (GO:0000726)3.71884425
19double-strand break repair via nonhomologous end joining (GO:0006303)3.71884425
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.71423195
21regulation of mitotic spindle checkpoint (GO:1903504)3.71423195
22cullin deneddylation (GO:0010388)3.64265477
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63482015
24proteasome assembly (GO:0043248)3.61549043
25maturation of SSU-rRNA (GO:0030490)3.58280725
26ribosomal small subunit assembly (GO:0000028)3.58053971
27spliceosomal snRNP assembly (GO:0000387)3.57706387
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.51016947
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.51016947
30telomere maintenance via telomere lengthening (GO:0010833)3.48270605
31protein deneddylation (GO:0000338)3.47423499
32rRNA methylation (GO:0031167)3.42993482
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.42419678
34DNA ligation (GO:0006266)3.40485015
35DNA replication-independent nucleosome assembly (GO:0006336)3.39687944
36DNA replication-independent nucleosome organization (GO:0034724)3.39687944
37nucleotide-excision repair, DNA gap filling (GO:0006297)3.39216714
38DNA unwinding involved in DNA replication (GO:0006268)3.38093932
39synapsis (GO:0007129)3.34397697
40chaperone-mediated protein transport (GO:0072321)3.34039839
41kinetochore organization (GO:0051383)3.31919011
42rRNA processing (GO:0006364)3.29664965
43negative regulation of DNA-dependent DNA replication (GO:2000104)3.29415015
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28001714
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28001714
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.28001714
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27630326
48DNA replication-dependent nucleosome assembly (GO:0006335)3.26983659
49DNA replication-dependent nucleosome organization (GO:0034723)3.26983659
50resolution of meiotic recombination intermediates (GO:0000712)3.25979018
51rRNA metabolic process (GO:0016072)3.25751086
52ribosome biogenesis (GO:0042254)3.25641235
53termination of RNA polymerase I transcription (GO:0006363)3.25460143
54IMP biosynthetic process (GO:0006188)3.25389295
55histone exchange (GO:0043486)3.25382029
56* transcription-coupled nucleotide-excision repair (GO:0006283)3.25132996
57ribonucleoprotein complex biogenesis (GO:0022613)3.24354381
58transcription elongation from RNA polymerase I promoter (GO:0006362)3.23976442
59formation of translation preinitiation complex (GO:0001731)3.23438998
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21139661
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20372337
62pseudouridine synthesis (GO:0001522)3.20265265
63nucleobase biosynthetic process (GO:0046112)3.19998001
64spliceosomal complex assembly (GO:0000245)3.18699146
65ribosomal large subunit biogenesis (GO:0042273)3.18565214
66deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.16960497
67kinetochore assembly (GO:0051382)3.16164695
68GTP biosynthetic process (GO:0006183)3.16117293
69ribosomal small subunit biogenesis (GO:0042274)3.11914429
70metaphase plate congression (GO:0051310)3.09201110
71viral mRNA export from host cell nucleus (GO:0046784)3.08356721
72RNA capping (GO:0036260)3.07788838
737-methylguanosine RNA capping (GO:0009452)3.07788838
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.06294721
75UTP biosynthetic process (GO:0006228)3.05523620
76guanosine-containing compound biosynthetic process (GO:1901070)3.05458114
77histone mRNA metabolic process (GO:0008334)3.03918399
78recombinational repair (GO:0000725)3.02603335
79establishment of integrated proviral latency (GO:0075713)3.02092884
80replication fork processing (GO:0031297)3.01827725
817-methylguanosine mRNA capping (GO:0006370)3.00752909
82attachment of spindle microtubules to kinetochore (GO:0008608)2.99678577
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.98975191
84double-strand break repair via homologous recombination (GO:0000724)2.98857023
85fucose catabolic process (GO:0019317)2.97895644
86L-fucose metabolic process (GO:0042354)2.97895644
87L-fucose catabolic process (GO:0042355)2.97895644
88purine nucleobase biosynthetic process (GO:0009113)2.97624439
89protein localization to kinetochore (GO:0034501)2.97104936
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.96683983
91DNA damage response, detection of DNA damage (GO:0042769)2.95817125
92establishment of chromosome localization (GO:0051303)2.92946698
93transcription from RNA polymerase I promoter (GO:0006360)2.92112619
94cell wall macromolecule metabolic process (GO:0044036)2.91257668
95cell wall macromolecule catabolic process (GO:0016998)2.91257668
96pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90956219
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90949293
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90004961
99viral transcription (GO:0019083)2.89832625
100protein localization to chromosome, centromeric region (GO:0071459)2.88129970
101DNA-templated transcription, termination (GO:0006353)2.87703750
102translational termination (GO:0006415)2.85522077
103mismatch repair (GO:0006298)2.85150228
104spindle checkpoint (GO:0031577)2.84587257
105regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84156403
106regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84156403
107regulation of sister chromatid cohesion (GO:0007063)2.83969062
108pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.82292087
109deoxyribonucleotide biosynthetic process (GO:0009263)2.81802725
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.80406018
111translational initiation (GO:0006413)2.80182547
112telomere organization (GO:0032200)2.79292836
113intracellular protein transmembrane import (GO:0044743)2.78873116
114RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78811131
115tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78811131
116telomere maintenance (GO:0000723)2.78094490
117RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77917787
118respiratory chain complex IV assembly (GO:0008535)2.77909642
119mRNA splicing, via spliceosome (GO:0000398)2.77558665
120RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.77558665
121RNA splicing, via transesterification reactions (GO:0000375)2.77434882
122regulation of double-strand break repair via homologous recombination (GO:0010569)2.76991670
123mitotic spindle checkpoint (GO:0071174)2.76078012
124IMP metabolic process (GO:0046040)2.75907760
125maturation of 5.8S rRNA (GO:0000460)2.75359410
126regulation of sister chromatid segregation (GO:0033045)2.74993586
127regulation of mitotic sister chromatid separation (GO:0010965)2.74993586
128regulation of mitotic sister chromatid segregation (GO:0033047)2.74993586
129centriole replication (GO:0007099)2.74196228
130pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.74123448
131transcription initiation from RNA polymerase I promoter (GO:0006361)2.73523302
132DNA-templated transcription, elongation (GO:0006354)2.72737205
133DNA catabolic process, exonucleolytic (GO:0000738)2.72404812
134transcription elongation from RNA polymerase II promoter (GO:0006368)2.72366498
135cellular component biogenesis (GO:0044085)2.72128111
136intraciliary transport (GO:0042073)2.72120091
137cell cycle G1/S phase transition (GO:0044843)2.72083722
138G1/S transition of mitotic cell cycle (GO:0000082)2.72083722
139protein K6-linked ubiquitination (GO:0085020)2.72056318
140peptidyl-histidine modification (GO:0018202)2.71357907
141postreplication repair (GO:0006301)2.69701359
142negative regulation of DNA recombination (GO:0045910)2.69053410
143meiotic chromosome segregation (GO:0045132)2.67287930
144mitochondrial DNA replication (GO:0006264)2.67113620
145negative regulation of sister chromatid segregation (GO:0033046)2.65674807
146negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65674807
147negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65674807
148negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65674807
149negative regulation of mitotic sister chromatid separation (GO:2000816)2.65674807
150maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64459175
151mitochondrial RNA metabolic process (GO:0000959)2.62819457
152negative regulation of chromosome segregation (GO:0051985)2.61950701
153positive regulation of chromosome segregation (GO:0051984)2.59716787
154regulation of centriole replication (GO:0046599)2.58439004
155preassembly of GPI anchor in ER membrane (GO:0016254)2.58044170
156mitochondrial respiratory chain complex assembly (GO:0033108)2.57335853
157organelle disassembly (GO:1903008)2.55535256
158ubiquinone metabolic process (GO:0006743)2.54633198
159protein complex biogenesis (GO:0070271)2.54159778
160ribosome assembly (GO:0042255)2.53931535
161protein-cofactor linkage (GO:0018065)2.53923335
162water-soluble vitamin biosynthetic process (GO:0042364)2.52858249
163regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.52673066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.43193656
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.39599573
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.04819178
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80680678
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43040483
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.41940737
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.20892394
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02247423
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.99669384
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94682875
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.91026154
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87305359
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.79636580
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77059028
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74565441
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67135423
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60482848
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.59271974
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58796103
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58145617
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55876113
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55659775
23VDR_22108803_ChIP-Seq_LS180_Human2.53069987
24ZNF274_21170338_ChIP-Seq_K562_Hela2.50159333
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42114110
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37707982
27VDR_23849224_ChIP-Seq_CD4+_Human2.37572617
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30817317
29FOXP3_21729870_ChIP-Seq_TREG_Human2.25243738
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20979792
31DCP1A_22483619_ChIP-Seq_HELA_Human2.17333754
32XRN2_22483619_ChIP-Seq_HELA_Human2.08983797
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04456893
34* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02808095
35YY1_21170310_ChIP-Seq_MESCs_Mouse2.00532704
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00085865
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98974800
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94594418
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92891944
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.90633931
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89931248
42IGF1R_20145208_ChIP-Seq_DFB_Human1.87865229
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86739321
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81707914
45ELK1_19687146_ChIP-ChIP_HELA_Human1.81632382
46GABP_19822575_ChIP-Seq_HepG2_Human1.80365304
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80343100
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79328654
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76745958
50CIITA_25753668_ChIP-Seq_RAJI_Human1.74138677
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71633084
52TTF2_22483619_ChIP-Seq_HELA_Human1.71538618
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.68188459
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.66659809
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66414570
56TAF15_26573619_Chip-Seq_HEK293_Human1.62647694
57GBX2_23144817_ChIP-Seq_PC3_Human1.61931156
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54426912
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54380148
60P300_19829295_ChIP-Seq_ESCs_Human1.53453419
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.47242802
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42842054
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38838358
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37239093
65AR_21909140_ChIP-Seq_LNCAP_Human1.36241337
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35875844
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35636315
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34837954
69* TP63_19390658_ChIP-ChIP_HaCaT_Human1.34112965
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33922175
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33616240
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33263250
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30258421
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30222736
75* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29494772
76IRF1_19129219_ChIP-ChIP_H3396_Human1.26489830
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25948628
78KDM5A_27292631_Chip-Seq_BREAST_Human1.22670359
79MYC_18940864_ChIP-ChIP_HL60_Human1.22591273
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21723393
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20145738
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19877637
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19416131
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13910098
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11939213
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.11630281
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11459910
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.10971202
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10449650
90CBP_20019798_ChIP-Seq_JUKART_Human1.09901004
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09901004
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07644524
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07375719
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06578262
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05222370
96ER_23166858_ChIP-Seq_MCF-7_Human1.04385028
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03794372
98* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03699421
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03502872
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03372365
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.03218706
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02957378
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02225986
104* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01601206
105BCAT_22108803_ChIP-Seq_LS180_Human1.00117014
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99419982
107SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99366674
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98784428
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96710403
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96263158
111* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95636904
112KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93354401
113TP53_22573176_ChIP-Seq_HFKS_Human0.92380685
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91654684
115FUS_26573619_Chip-Seq_HEK293_Human0.89532543
116SOX2_19829295_ChIP-Seq_ESCs_Human0.89470911
117NANOG_19829295_ChIP-Seq_ESCs_Human0.89470911
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86689414
119EWS_26573619_Chip-Seq_HEK293_Human0.86059975
120TCF4_22108803_ChIP-Seq_LS180_Human0.84887723
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83407071
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81950099
123SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78930272
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77402536
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77204396
126FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76079378
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.73977272
128SPI1_23547873_ChIP-Seq_NB4_Human0.71504392
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.70362574
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69219965
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69204403
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66337841
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64409056
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.62308201
135KLF4_18555785_ChIP-Seq_MESCs_Mouse0.61780604
136TBX5_21415370_ChIP-Seq_HL-1_Mouse0.61383753
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.60946693
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.57694238
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.57163768
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.56742676
141NFE2_27457419_Chip-Seq_LIVER_Mouse0.56652162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.92000199
2MP0003693_abnormal_embryo_hatching4.39358404
3MP0010094_abnormal_chromosome_stability4.03008853
4MP0003111_abnormal_nucleus_morphology3.94260844
5* MP0008058_abnormal_DNA_repair3.72703402
6MP0004957_abnormal_blastocyst_morpholog3.42202069
7MP0003077_abnormal_cell_cycle3.38861057
8MP0008932_abnormal_embryonic_tissue2.92882736
9MP0002396_abnormal_hematopoietic_system2.67115700
10MP0008007_abnormal_cellular_replicative2.49075212
11MP0008877_abnormal_DNA_methylation2.38560222
12MP0003787_abnormal_imprinting2.21670813
13MP0003890_abnormal_embryonic-extraembry2.20999691
14MP0001529_abnormal_vocalization2.20185723
15MP0002234_abnormal_pharynx_morphology1.94120571
16MP0009697_abnormal_copulation1.92640931
17MP0009379_abnormal_foot_pigmentation1.89403378
18MP0006292_abnormal_olfactory_placode1.86654053
19MP0000372_irregular_coat_pigmentation1.81852810
20MP0005410_abnormal_fertilization1.77940665
21MP0002210_abnormal_sex_determination1.77289146
22MP0008995_early_reproductive_senescence1.76872486
23MP0003195_calcinosis1.74870794
24MP0001929_abnormal_gametogenesis1.68604796
25MP0003011_delayed_dark_adaptation1.64565757
26MP0003136_yellow_coat_color1.63813744
27MP0009333_abnormal_splenocyte_physiolog1.61118404
28MP0002938_white_spotting1.60625412
29* MP0005253_abnormal_eye_physiology1.57354563
30MP0002102_abnormal_ear_morphology1.55741733
31MP0003786_premature_aging1.55585589
32MP0000049_abnormal_middle_ear1.55113480
33MP0000350_abnormal_cell_proliferation1.55098338
34MP0002233_abnormal_nose_morphology1.47127780
35MP0001145_abnormal_male_reproductive1.44321001
36MP0002132_abnormal_respiratory_system1.43113271
37MP0002837_dystrophic_cardiac_calcinosis1.39959847
38MP0003718_maternal_effect1.39948059
39MP0001730_embryonic_growth_arrest1.39487964
40MP0001286_abnormal_eye_development1.38776792
41MP0003315_abnormal_perineum_morphology1.37863499
42MP0001293_anophthalmia1.37523798
43MP0003698_abnormal_male_reproductive1.37096565
44MP0003941_abnormal_skin_development1.34800714
45MP0004133_heterotaxia1.33234967
46MP0005551_abnormal_eye_electrophysiolog1.33232552
47MP0000383_abnormal_hair_follicle1.32946981
48MP0001188_hyperpigmentation1.31527788
49MP0003763_abnormal_thymus_physiology1.30920472
50MP0005623_abnormal_meninges_morphology1.29056732
51MP0002160_abnormal_reproductive_system1.25342298
52MP0003121_genomic_imprinting1.23670684
53MP0000490_abnormal_crypts_of1.22938035
54MP0000653_abnormal_sex_gland1.20226958
55MP0003950_abnormal_plasma_membrane1.18958119
56MP0000516_abnormal_urinary_system1.18512513
57MP0005367_renal/urinary_system_phenotyp1.18512513
58MP0006035_abnormal_mitochondrial_morpho1.18425387
59MP0005084_abnormal_gallbladder_morpholo1.17782424
60MP0002085_abnormal_embryonic_tissue1.15353436
61MP0004147_increased_porphyrin_level1.11747889
62MP0000647_abnormal_sebaceous_gland1.09966776
63* MP0005391_vision/eye_phenotype1.09647484
64MP0005075_abnormal_melanosome_morpholog1.07560365
65MP0006276_abnormal_autonomic_nervous1.07359091
66MP0004134_abnormal_chest_morphology1.05734815
67MP0000427_abnormal_hair_cycle1.04160971
68MP0000566_synostosis1.03311836
69MP0002736_abnormal_nociception_after1.03115035
70MP0002095_abnormal_skin_pigmentation1.03018459
71* MP0000313_abnormal_cell_death1.01073573
72MP0005409_darkened_coat_color0.99887890
73MP0002249_abnormal_larynx_morphology0.99731099
74MP0000015_abnormal_ear_pigmentation0.98625263
75MP0000703_abnormal_thymus_morphology0.97840585
76MP0010030_abnormal_orbit_morphology0.97419329
77MP0003937_abnormal_limbs/digits/tail_de0.97298312
78MP0001672_abnormal_embryogenesis/_devel0.96354857
79MP0005380_embryogenesis_phenotype0.96354857
80MP0005174_abnormal_tail_pigmentation0.94975666
81MP0001485_abnormal_pinna_reflex0.94903010
82MP0006082_CNS_inflammation0.93952292
83MP0001697_abnormal_embryo_size0.93827144
84MP0006072_abnormal_retinal_apoptosis0.92502605
85MP0004808_abnormal_hematopoietic_stem0.91813380
86MP0001984_abnormal_olfaction0.91084204
87MP0000631_abnormal_neuroendocrine_gland0.90644843
88MP0002080_prenatal_lethality0.90471658
89MP0010678_abnormal_skin_adnexa0.88981782
90MP0003806_abnormal_nucleotide_metabolis0.88952222
91MP0002398_abnormal_bone_marrow0.88211922
92MP0002751_abnormal_autonomic_nervous0.86814599
93MP0002697_abnormal_eye_size0.85353536
94MP0008789_abnormal_olfactory_epithelium0.85174005
95MP0003755_abnormal_palate_morphology0.85087262
96MP0006036_abnormal_mitochondrial_physio0.84885069
97MP0003123_paternal_imprinting0.84756789
98MP0005171_absent_coat_pigmentation0.83569478
99MP0003183_abnormal_peptide_metabolism0.83465650
100MP0002161_abnormal_fertility/fecundity0.82350499
101* MP0002019_abnormal_tumor_incidence0.82249676
102* MP0005195_abnormal_posterior_eye0.82189315
103MP0003880_abnormal_central_pattern0.80862800
104MP0004215_abnormal_myocardial_fiber0.79712329
105MP0005248_abnormal_Harderian_gland0.79516017
106MP0003938_abnormal_ear_development0.79185117
107MP0000358_abnormal_cell_content/0.78795068
108MP0003861_abnormal_nervous_system0.78641492
109MP0001119_abnormal_female_reproductive0.78578031
110MP0005389_reproductive_system_phenotype0.77797590
111MP0001299_abnormal_eye_distance/0.77579887
112MP0009703_decreased_birth_body0.77428574
113MP0003186_abnormal_redox_activity0.77061656
114MP0001324_abnormal_eye_pigmentation0.75791838
115* MP0002752_abnormal_somatic_nervous0.75721602
116MP0009046_muscle_twitch0.75390292
117MP0000569_abnormal_digit_pigmentation0.75016307
118MP0004142_abnormal_muscle_tone0.74883061
119MP0009672_abnormal_birth_weight0.74692782
120MP0003119_abnormal_digestive_system0.74237223
121MP0004381_abnormal_hair_follicle0.73774815
122MP0003984_embryonic_growth_retardation0.73256199
123MP0004197_abnormal_fetal_growth/weight/0.73130176
124MP0002282_abnormal_trachea_morphology0.72797736
125MP0005379_endocrine/exocrine_gland_phen0.72607053
126MP0005671_abnormal_response_to0.71732878
127MP0003122_maternal_imprinting0.71441739
128MP0006054_spinal_hemorrhage0.71128040
129MP0010307_abnormal_tumor_latency0.71062866
130MP0002254_reproductive_system_inflammat0.70803489
131MP0002084_abnormal_developmental_patter0.70536354
132MP0002088_abnormal_embryonic_growth/wei0.68161758
133MP0000462_abnormal_digestive_system0.67851789
134MP0003172_abnormal_lysosome_physiology0.67242265
135MP0002075_abnormal_coat/hair_pigmentati0.65284416
136MP0002098_abnormal_vibrissa_morphology0.65148140
137MP0002638_abnormal_pupillary_reflex0.64978540
138MP0003567_abnormal_fetal_cardiomyocyte0.63391818
139MP0002163_abnormal_gland_morphology0.62752541
140MP0001545_abnormal_hematopoietic_system0.61823950
141MP0005397_hematopoietic_system_phenotyp0.61823950
142MP0005394_taste/olfaction_phenotype0.61720053
143MP0005499_abnormal_olfactory_system0.61720053
144MP0000778_abnormal_nervous_system0.61117175

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.47850339
2Birth length less than 3rd percentile (HP:0003561)4.47262550
3Chromsome breakage (HP:0040012)4.23790394
4Reticulocytopenia (HP:0001896)4.06947942
5Cerebral hypomyelination (HP:0006808)3.73872930
6Breast hypoplasia (HP:0003187)3.58878754
7Sex reversal (HP:0012245)3.55505871
8Abnormal sex determination (HP:0012244)3.55505871
9Abnormality of the preputium (HP:0100587)3.41658822
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.27708403
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.22528330
12Hyperglycinemia (HP:0002154)3.21346483
13Abnormal respiratory motile cilium physiology (HP:0012261)3.11104397
14Abnormal ciliary motility (HP:0012262)3.10677363
15Chronic bronchitis (HP:0004469)3.08212731
16Abnormal respiratory motile cilium morphology (HP:0005938)3.07633042
17Abnormal respiratory epithelium morphology (HP:0012253)3.07633042
18Abnormality of chromosome stability (HP:0003220)3.06777436
19Aplastic anemia (HP:0001915)2.95157880
20Meckel diverticulum (HP:0002245)2.94229181
2111 pairs of ribs (HP:0000878)2.92302876
22Abnormality of the ileum (HP:0001549)2.86738758
23Duplicated collecting system (HP:0000081)2.83747269
24Type I transferrin isoform profile (HP:0003642)2.82862195
25Abnormality of cells of the erythroid lineage (HP:0012130)2.80093774
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.79969958
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.72681611
28Abnormal number of erythroid precursors (HP:0012131)2.71676011
29Progressive muscle weakness (HP:0003323)2.65953192
30Bone marrow hypocellularity (HP:0005528)2.59537386
31Facial cleft (HP:0002006)2.58373497
32Severe visual impairment (HP:0001141)2.57856197
33Oral leukoplakia (HP:0002745)2.57077882
34Nephronophthisis (HP:0000090)2.54096156
35Lipid accumulation in hepatocytes (HP:0006561)2.52434087
36Medulloblastoma (HP:0002885)2.50461266
37Medial flaring of the eyebrow (HP:0010747)2.49098439
38Increased hepatocellular lipid droplets (HP:0006565)2.47932615
39Renal cortical cysts (HP:0000803)2.47217564
40Hyperglycinuria (HP:0003108)2.47031420
41Acute encephalopathy (HP:0006846)2.46835214
42Colon cancer (HP:0003003)2.46465688
43Patellar aplasia (HP:0006443)2.45735326
44Volvulus (HP:0002580)2.44297928
45Premature graying of hair (HP:0002216)2.39157119
46Absent/shortened dynein arms (HP:0200106)2.35152814
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.35152814
48Intestinal atresia (HP:0011100)2.33688003
49Molar tooth sign on MRI (HP:0002419)2.33505475
50Abnormality of midbrain morphology (HP:0002418)2.33505475
51Ectopic kidney (HP:0000086)2.33391959
52Abnormality of the renal collecting system (HP:0004742)2.33152831
53Hypergonadotropic hypogonadism (HP:0000815)2.31313933
54Oligodactyly (hands) (HP:0001180)2.30159606
553-Methylglutaconic aciduria (HP:0003535)2.29440583
56True hermaphroditism (HP:0010459)2.29142797
57Absent thumb (HP:0009777)2.28612099
58Aplasia/Hypoplasia of the patella (HP:0006498)2.28514509
59Aplasia/hypoplasia of the uterus (HP:0008684)2.28263265
60Increased CSF lactate (HP:0002490)2.28182351
61Abnormality of glycine metabolism (HP:0010895)2.27858010
62Abnormality of serine family amino acid metabolism (HP:0010894)2.27858010
63Abnormality of the renal medulla (HP:0100957)2.27082271
64Rhinitis (HP:0012384)2.27053326
65Pancytopenia (HP:0001876)2.24594410
66Duodenal stenosis (HP:0100867)2.24275992
67Small intestinal stenosis (HP:0012848)2.24275992
68Progressive macrocephaly (HP:0004481)2.21911504
69Mitochondrial inheritance (HP:0001427)2.20488833
70Myelodysplasia (HP:0002863)2.19415434
71Microvesicular hepatic steatosis (HP:0001414)2.19336791
72Abnormal spermatogenesis (HP:0008669)2.18583849
73CNS hypomyelination (HP:0003429)2.18553495
74Triphalangeal thumb (HP:0001199)2.16602308
75Congenital primary aphakia (HP:0007707)2.16356706
76Cellular immunodeficiency (HP:0005374)2.16079336
77Embryonal renal neoplasm (HP:0011794)2.15798622
78Abnormality of the renal cortex (HP:0011035)2.15608355
79Nephrogenic diabetes insipidus (HP:0009806)2.13746809
80Pallor (HP:0000980)2.12992172
81Rough bone trabeculation (HP:0100670)2.12882795
82Short tibia (HP:0005736)2.12128525
83Abnormality of the carotid arteries (HP:0005344)2.11722603
84Abnormality of methionine metabolism (HP:0010901)2.11534373
85Sloping forehead (HP:0000340)2.10730388
86Missing ribs (HP:0000921)2.10644060
87Abnormal biliary tract physiology (HP:0012439)2.08130670
88Bile duct proliferation (HP:0001408)2.08130670
89Genital tract atresia (HP:0001827)2.07216368
90Gait imbalance (HP:0002141)2.06902206
91Septo-optic dysplasia (HP:0100842)2.05306889
92Selective tooth agenesis (HP:0001592)2.05092910
93Horseshoe kidney (HP:0000085)2.04966087
94Gastrointestinal atresia (HP:0002589)2.04891004
95Absent radius (HP:0003974)2.04696566
96Anophthalmia (HP:0000528)2.04280072
97Abnormality of serum amino acid levels (HP:0003112)2.04270428
98Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03914093
99Unilateral renal agenesis (HP:0000122)2.03295741
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.02291547
101Cleft eyelid (HP:0000625)2.02175988
102Abnormality of DNA repair (HP:0003254)2.00847932
103Vaginal atresia (HP:0000148)2.00668600
104Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00093167
105Abnormal protein glycosylation (HP:0012346)1.98617478
106Abnormal glycosylation (HP:0012345)1.98617478
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98617478
108Abnormal protein N-linked glycosylation (HP:0012347)1.98617478
109Esophageal atresia (HP:0002032)1.98157867
110Abnormality of the anterior horn cell (HP:0006802)1.96926474
111Degeneration of anterior horn cells (HP:0002398)1.96926474
112Macrocytic anemia (HP:0001972)1.95694683
113Nephroblastoma (Wilms tumor) (HP:0002667)1.95630971
114Poor head control (HP:0002421)1.94545356
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94274059
116Glossoptosis (HP:0000162)1.93276238
117Renal Fanconi syndrome (HP:0001994)1.92820120
118Supernumerary spleens (HP:0009799)1.92109756
119Preaxial hand polydactyly (HP:0001177)1.90592594
120Petechiae (HP:0000967)1.89204318
121Cortical dysplasia (HP:0002539)1.88966425
122Aplasia involving forearm bones (HP:0009822)1.88935888
123Absent forearm bone (HP:0003953)1.88935888
124Abnormal number of incisors (HP:0011064)1.88524780
125Optic nerve hypoplasia (HP:0000609)1.88027371
126Bronchiectasis (HP:0002110)1.87600921
127Lactic acidosis (HP:0003128)1.86265467
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86165142
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.86120236
130Abnormal lung lobation (HP:0002101)1.83987082
131Abnormality of the duodenum (HP:0002246)1.83074267
132Pancreatic fibrosis (HP:0100732)1.82965367
133Cerebral edema (HP:0002181)1.82445746
134Postaxial hand polydactyly (HP:0001162)1.82102901
135Renal hypoplasia (HP:0000089)1.81785289
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81009783
137Tracheoesophageal fistula (HP:0002575)1.80864328
138Bifid tongue (HP:0010297)1.80272289
139Acute necrotizing encephalopathy (HP:0006965)1.80248029
140Sclerocornea (HP:0000647)1.79884428
141Postaxial foot polydactyly (HP:0001830)1.78860952
142Methylmalonic acidemia (HP:0002912)1.78784474
143Neoplasm of the pancreas (HP:0002894)1.78320109
144Dandy-Walker malformation (HP:0001305)1.78170548
145Pancreatic cysts (HP:0001737)1.77043843
146Aplasia/Hypoplasia of the sternum (HP:0006714)1.76612469
147Congenital, generalized hypertrichosis (HP:0004540)1.76606429
148Optic disc pallor (HP:0000543)1.74647707
149Cystic liver disease (HP:0006706)1.73519528
150Male pseudohermaphroditism (HP:0000037)1.73387826
151Pendular nystagmus (HP:0012043)1.72603893
152Premature ovarian failure (HP:0008209)1.72125637
153Chorioretinal coloboma (HP:0000567)1.72121725
154Adrenal hypoplasia (HP:0000835)1.72006474
155Scrotal hypoplasia (HP:0000046)1.71870429
156Tubulointerstitial nephritis (HP:0001970)1.71649140
157Type II lissencephaly (HP:0007260)1.70201160
158Hepatocellular necrosis (HP:0001404)1.69579255
159Retinal dysplasia (HP:0007973)1.69197411
160Increased serum lactate (HP:0002151)1.69107089
161Abnormal mitochondria in muscle tissue (HP:0008316)1.68497309
162Clubbing of toes (HP:0100760)1.68496644
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68218363
164Absent epiphyses (HP:0010577)1.68218363
165Oligodactyly (HP:0012165)1.67967279
166Abnormality of the labia minora (HP:0012880)1.67863242
167Glioma (HP:0009733)1.66799613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.01020322
2WEE13.43112688
3SRPK13.26664045
4BUB13.17270779
5STK163.06892739
6CDC72.94751863
7PASK2.71876850
8EIF2AK12.71059355
9EIF2AK32.69479539
10PNCK2.55578841
11TLK12.35858892
12WNK32.32549324
13NME22.27925962
14VRK12.21987936
15TNIK2.10669316
16NEK11.99419310
17FRK1.94307710
18TRIM281.93683549
19MKNK21.86893125
20IRAK11.77874878
21MKNK11.73319466
22MST41.67646462
23TSSK61.66309937
24MAP3K41.65717841
25TTK1.65499585
26MAP4K21.61848579
27PBK1.58209660
28BCKDK1.55229220
29STK38L1.54958016
30BRSK21.52552690
31DYRK31.50104888
32CCNB11.48791907
33VRK21.48510078
34PLK41.46285467
35ERBB31.44254594
36PLK11.41179293
37BCR1.40326991
38CHEK21.33991510
39CASK1.32226750
40ATR1.31093058
41NEK21.29725557
42WNK41.24136753
43CDK71.18847683
44ZAK1.18285804
45PLK31.17614403
46BRSK11.16697991
47DYRK21.16561367
48CSNK1G21.15194323
49AURKB1.14629120
50TESK11.13298126
51EIF2AK21.12551731
52BRD41.12473429
53SCYL21.12190990
54STK391.11990078
55AURKA1.08954199
56ACVR1B1.08642955
57MAP2K71.07758170
58INSRR1.07267150
59PLK21.04982660
60PINK10.94173747
61CLK10.93932604
62LATS10.93161804
63CHEK10.91931203
64MAPK130.89676430
65PRPF4B0.89491498
66MARK10.88688508
67IRAK40.86419823
68CDK30.86293547
69RPS6KA40.85900523
70TAF10.85871320
71OXSR10.84995973
72NME10.80722075
73TXK0.80658614
74CDK80.80074245
75YES10.77821304
76LIMK10.77523460
77TGFBR10.75478532
78TAOK20.74833988
79MUSK0.72993603
80ATM0.71227120
81BTK0.67676705
82IRAK20.66751964
83CSNK2A20.61951737
84SIK30.61115112
85PIM20.60203425
86CDK40.59052605
87PIK3CA0.57908593
88EPHA40.57306832
89PRKCG0.56986256
90CDK10.55834502
91CSNK2A10.55676333
92TESK20.55238341
93PAK30.54910297
94DYRK1A0.54614414
95CDK20.54505591
96MAP4K10.54444009
97UHMK10.52329997
98FGFR20.51668284
99STK30.51314075
100NUAK10.51092438
101PDK20.49717602
102RPS6KA50.47400444
103PDK30.46531113
104PDK40.46531113
105GRK10.45212944
106PRKCE0.44979887
107GRK70.44571461
108NEK60.43400445
109PAK10.42750648
110FGFR10.42594561
111BRAF0.41860487
112MINK10.40787119
113CSK0.40747017
114IRAK30.38687480
115CDK190.38641884
116OBSCN0.38338111
117CSNK1G30.37840791
118MAP3K80.37505158
119STK100.37102535
120TEC0.32234831
121PRKDC0.32157689
122CAMKK20.31076691
123MAP3K60.29381265
124STK240.28869792
125CSNK1E0.27513776
126PRKCQ0.27170653
127LYN0.26993559
128ERBB40.26100700
129CSNK1D0.26073210
130CSNK1A1L0.24901925
131CSNK1A10.24464420
132RPS6KB20.24267445
133BMPR1B0.23402911
134CSF1R0.23267491
135ADRBK20.22930630
136CSNK1G10.22607028
137ABL20.21862283
138NTRK20.21751507
139PRKCI0.20956811
140HIPK20.20192394

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62468491
2RNA polymerase_Homo sapiens_hsa030203.92240984
3Mismatch repair_Homo sapiens_hsa034303.74395690
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.59021184
5Proteasome_Homo sapiens_hsa030503.38647982
6Spliceosome_Homo sapiens_hsa030403.27987628
7Ribosome_Homo sapiens_hsa030103.26914229
8Base excision repair_Homo sapiens_hsa034103.01828451
9Homologous recombination_Homo sapiens_hsa034402.89352354
10Pyrimidine metabolism_Homo sapiens_hsa002402.84117214
11Basal transcription factors_Homo sapiens_hsa030222.80621474
12* Nucleotide excision repair_Homo sapiens_hsa034202.72097088
13RNA transport_Homo sapiens_hsa030132.70919159
14Propanoate metabolism_Homo sapiens_hsa006402.46403610
15Fanconi anemia pathway_Homo sapiens_hsa034602.46086838
16Cell cycle_Homo sapiens_hsa041102.37929302
17One carbon pool by folate_Homo sapiens_hsa006702.12782463
18Protein export_Homo sapiens_hsa030602.03892630
19RNA degradation_Homo sapiens_hsa030182.02905145
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98221164
21Non-homologous end-joining_Homo sapiens_hsa034501.97612022
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96155248
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.84600789
24Fatty acid elongation_Homo sapiens_hsa000621.82246345
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81125998
26Purine metabolism_Homo sapiens_hsa002301.77718871
27mRNA surveillance pathway_Homo sapiens_hsa030151.76487295
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75606180
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70406309
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48611570
31Butanoate metabolism_Homo sapiens_hsa006501.48101241
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44379444
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42529787
34Pyruvate metabolism_Homo sapiens_hsa006201.36010185
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12311944
36Systemic lupus erythematosus_Homo sapiens_hsa053221.10760887
37Epstein-Barr virus infection_Homo sapiens_hsa051691.09569946
38Huntingtons disease_Homo sapiens_hsa050161.06366493
39Peroxisome_Homo sapiens_hsa041461.05698164
40Fatty acid metabolism_Homo sapiens_hsa012121.04895738
41N-Glycan biosynthesis_Homo sapiens_hsa005100.99487261
42Oxidative phosphorylation_Homo sapiens_hsa001900.95244231
43Caffeine metabolism_Homo sapiens_hsa002320.94612375
44p53 signaling pathway_Homo sapiens_hsa041150.89680408
45Parkinsons disease_Homo sapiens_hsa050120.88047623
46Herpes simplex infection_Homo sapiens_hsa051680.87587682
47Vitamin B6 metabolism_Homo sapiens_hsa007500.81215763
48Phototransduction_Homo sapiens_hsa047440.81162032
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80593245
50Oocyte meiosis_Homo sapiens_hsa041140.80282297
51* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76266105
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74871072
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73950222
54Glutathione metabolism_Homo sapiens_hsa004800.72981071
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72492174
56Fatty acid degradation_Homo sapiens_hsa000710.70721350
57beta-Alanine metabolism_Homo sapiens_hsa004100.70517982
58Selenocompound metabolism_Homo sapiens_hsa004500.68478468
59Carbon metabolism_Homo sapiens_hsa012000.67306317
60Other glycan degradation_Homo sapiens_hsa005110.66838856
61Tryptophan metabolism_Homo sapiens_hsa003800.65152463
62Viral carcinogenesis_Homo sapiens_hsa052030.64137900
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63538910
64Basal cell carcinoma_Homo sapiens_hsa052170.63014486
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59069066
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59043602
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59031619
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58965471
69Alcoholism_Homo sapiens_hsa050340.56642279
70HTLV-I infection_Homo sapiens_hsa051660.56613378
71Primary immunodeficiency_Homo sapiens_hsa053400.56142725
72Viral myocarditis_Homo sapiens_hsa054160.53525744
73Taste transduction_Homo sapiens_hsa047420.53233475
74Vitamin digestion and absorption_Homo sapiens_hsa049770.50527860
75Linoleic acid metabolism_Homo sapiens_hsa005910.50296146
76Retinol metabolism_Homo sapiens_hsa008300.49509564
77Biosynthesis of amino acids_Homo sapiens_hsa012300.48416592
78Nitrogen metabolism_Homo sapiens_hsa009100.47850805
79Sphingolipid metabolism_Homo sapiens_hsa006000.46209374
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45695827
81Nicotine addiction_Homo sapiens_hsa050330.44071100
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44004081
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43733743
84Folate biosynthesis_Homo sapiens_hsa007900.43488334
85Antigen processing and presentation_Homo sapiens_hsa046120.43332553
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43305548
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.41930850
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.41278662
89Olfactory transduction_Homo sapiens_hsa047400.41268360
90Autoimmune thyroid disease_Homo sapiens_hsa053200.41203734
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40781308
92Alzheimers disease_Homo sapiens_hsa050100.40047038
93Lysine degradation_Homo sapiens_hsa003100.39751855
94Measles_Homo sapiens_hsa051620.39494944
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.39452624
96Cardiac muscle contraction_Homo sapiens_hsa042600.39374551
97Hedgehog signaling pathway_Homo sapiens_hsa043400.38585563
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38118348
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37860842
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36730008
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.35505978
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.35254464
103Regulation of autophagy_Homo sapiens_hsa041400.33891541
104Chemical carcinogenesis_Homo sapiens_hsa052040.33658123
105Colorectal cancer_Homo sapiens_hsa052100.33406859
106Sulfur relay system_Homo sapiens_hsa041220.32864885
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32488715
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.32394396
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32267400
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32086354
111Metabolic pathways_Homo sapiens_hsa011000.31195351
112Hepatitis B_Homo sapiens_hsa051610.31149181
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30131003
114Asthma_Homo sapiens_hsa053100.29996017
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29928774
116Arginine and proline metabolism_Homo sapiens_hsa003300.29462303
117Legionellosis_Homo sapiens_hsa051340.29108727
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24696052
119Allograft rejection_Homo sapiens_hsa053300.24522037
120Hematopoietic cell lineage_Homo sapiens_hsa046400.24047246
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23912265
122Wnt signaling pathway_Homo sapiens_hsa043100.23242786
123Ether lipid metabolism_Homo sapiens_hsa005650.21821260
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21785408
125Pentose phosphate pathway_Homo sapiens_hsa000300.20725539
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20487402
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19243713
128Apoptosis_Homo sapiens_hsa042100.18282810
129T cell receptor signaling pathway_Homo sapiens_hsa046600.18030374
130Graft-versus-host disease_Homo sapiens_hsa053320.17984449
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17929764
132Arachidonic acid metabolism_Homo sapiens_hsa005900.17546591
133MicroRNAs in cancer_Homo sapiens_hsa052060.16330208
134Acute myeloid leukemia_Homo sapiens_hsa052210.15352643
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14421734
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.13058298
137Steroid biosynthesis_Homo sapiens_hsa001000.12432387
138Axon guidance_Homo sapiens_hsa043600.11320919
139Small cell lung cancer_Homo sapiens_hsa052220.11209422
140Melanoma_Homo sapiens_hsa052180.09717715
141Hippo signaling pathway_Homo sapiens_hsa043900.09697161
142Type I diabetes mellitus_Homo sapiens_hsa049400.09384011
143TGF-beta signaling pathway_Homo sapiens_hsa043500.09074672
144Pathways in cancer_Homo sapiens_hsa052000.08839541
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.08263664
146Influenza A_Homo sapiens_hsa051640.08106288

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