ERAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.88296409
2chromosome organization involved in meiosis (GO:0070192)8.23573892
3DNA methylation involved in gamete generation (GO:0043046)7.68629952
4male meiosis I (GO:0007141)7.53070883
5synaptonemal complex assembly (GO:0007130)7.20022728
6response to pheromone (GO:0019236)6.92819187
7male meiosis (GO:0007140)6.72891686
8positive regulation of meiosis (GO:0045836)6.72259216
9negative regulation of calcium ion-dependent exocytosis (GO:0045955)6.51307123
10synaptonemal complex organization (GO:0070193)6.47317775
11mitotic sister chromatid cohesion (GO:0007064)6.47311010
12sister chromatid cohesion (GO:0007062)6.39925019
13positive regulation of meiotic cell cycle (GO:0051446)6.29637066
14meiosis I (GO:0007127)6.00864446
15DNA synthesis involved in DNA repair (GO:0000731)5.95180780
16meiotic nuclear division (GO:0007126)5.91174572
17meiotic chromosome segregation (GO:0045132)5.63621419
18regulation of gene silencing by miRNA (GO:0060964)5.58919702
19regulation of gene silencing by RNA (GO:0060966)5.58919702
20regulation of posttranscriptional gene silencing (GO:0060147)5.58919702
21meiotic cell cycle process (GO:1903046)5.05433565
22negative regulation of meiosis (GO:0045835)5.00129083
23reciprocal meiotic recombination (GO:0007131)4.90095017
24reciprocal DNA recombination (GO:0035825)4.90095017
25single strand break repair (GO:0000012)4.84492822
26germ cell migration (GO:0008354)4.61608411
27DNA unwinding involved in DNA replication (GO:0006268)4.57552780
28maturation of SSU-rRNA (GO:0030490)4.53199976
29DNA replication initiation (GO:0006270)4.51968358
30folic acid-containing compound biosynthetic process (GO:0009396)4.50309125
31regulation of acrosome reaction (GO:0060046)4.49921334
32formation of translation preinitiation complex (GO:0001731)4.47427258
33mitotic metaphase plate congression (GO:0007080)4.45523229
34pyrimidine nucleobase catabolic process (GO:0006208)4.40156903
35nucleobase biosynthetic process (GO:0046112)4.29059422
36establishment of integrated proviral latency (GO:0075713)4.24442757
37regulation of DNA endoreduplication (GO:0032875)4.21743067
38ribosome biogenesis (GO:0042254)4.19661434
39DNA replication-dependent nucleosome organization (GO:0034723)4.17734235
40DNA replication-dependent nucleosome assembly (GO:0006335)4.17734235
41DNA strand elongation involved in DNA replication (GO:0006271)4.17054876
42resolution of meiotic recombination intermediates (GO:0000712)4.15704464
43regulation of meiotic cell cycle (GO:0051445)4.12414709
44histone H3-K9 demethylation (GO:0033169)4.09308948
45sex differentiation (GO:0007548)4.08685055
46regulation of helicase activity (GO:0051095)4.06319547
47nuclear pore organization (GO:0006999)3.96369542
48protein localization to kinetochore (GO:0034501)3.96281261
49ribosome assembly (GO:0042255)3.95145201
50DNA strand elongation (GO:0022616)3.93813822
51mitotic nuclear envelope disassembly (GO:0007077)3.92813266
52ribonucleoprotein complex biogenesis (GO:0022613)3.90631952
53gene silencing by RNA (GO:0031047)3.90199789
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.87494773
55somatic diversification of immune receptors via somatic mutation (GO:0002566)3.87494773
56pre-miRNA processing (GO:0031054)3.85983515
57purine nucleobase biosynthetic process (GO:0009113)3.82786614
58regulation of meiosis (GO:0040020)3.80551825
59IMP biosynthetic process (GO:0006188)3.80078517
60DNA replication checkpoint (GO:0000076)3.79654665
61metaphase plate congression (GO:0051310)3.79593588
62negative regulation of meiotic cell cycle (GO:0051447)3.77005444
63DNA deamination (GO:0045006)3.73992336
64spliceosomal snRNP assembly (GO:0000387)3.70009785
65ribosomal large subunit biogenesis (GO:0042273)3.66762176
66regulation of histone H3-K9 methylation (GO:0051570)3.65478215
67positive regulation of amino acid transport (GO:0051957)3.65082598
68nuclear envelope disassembly (GO:0051081)3.64535678
69membrane disassembly (GO:0030397)3.64535678
70telomere maintenance via semi-conservative replication (GO:0032201)3.64220427
71ribosomal small subunit biogenesis (GO:0042274)3.63611109
72protein complex localization (GO:0031503)3.63029495
73membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62073994
74meiotic cell cycle (GO:0051321)3.61500877
75negative regulation of histone methylation (GO:0031061)3.61357871
76histone H2A acetylation (GO:0043968)3.60721518
77positive regulation of male gonad development (GO:2000020)3.59152427
78histone arginine methylation (GO:0034969)3.59044250
79DNA methylation (GO:0006306)3.57644944
80DNA alkylation (GO:0006305)3.57644944
81heterochromatin organization (GO:0070828)3.57493008
82rRNA modification (GO:0000154)3.56912502
83viral transcription (GO:0019083)3.56294054
84chromatin remodeling at centromere (GO:0031055)3.52517363
85translational termination (GO:0006415)3.51790773
86establishment of mitochondrion localization (GO:0051654)3.51389385
87rRNA processing (GO:0006364)3.49509596
88nuclear pore complex assembly (GO:0051292)3.48231400
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.46626346
90paraxial mesoderm development (GO:0048339)3.46308203
91mitotic sister chromatid segregation (GO:0000070)3.42287787
92CENP-A containing nucleosome assembly (GO:0034080)3.38500182
93rRNA metabolic process (GO:0016072)3.37938955
94DNA duplex unwinding (GO:0032508)3.37928574
95DNA geometric change (GO:0032392)3.37386908
96translational initiation (GO:0006413)3.36799992
97microtubule nucleation (GO:0007020)3.36295796
98IMP metabolic process (GO:0046040)3.35919288
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32559022
100establishment of chromosome localization (GO:0051303)3.32496942
101nucleobase catabolic process (GO:0046113)3.32229712
102protein localization to chromosome (GO:0034502)3.31812543
103female gamete generation (GO:0007292)3.31477389
104histone H4-K12 acetylation (GO:0043983)3.30070629
105peptidyl-arginine omega-N-methylation (GO:0035247)3.29690043
106protein localization to chromosome, centromeric region (GO:0071459)3.29653384
107protein K6-linked ubiquitination (GO:0085020)3.29022587
108regulation of gene silencing (GO:0060968)3.28389737
109translational elongation (GO:0006414)3.27501596
110pseudouridine synthesis (GO:0001522)3.26562056
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26112947
112snRNA processing (GO:0016180)3.24149233
113telomere maintenance via telomere lengthening (GO:0010833)3.23849243
114kinetochore assembly (GO:0051382)3.20385874
115establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.20220870
116mitochondrion transport along microtubule (GO:0047497)3.20220870
117spliceosomal complex assembly (GO:0000245)3.19883340
118snRNA metabolic process (GO:0016073)3.19813326
119maturation of 5.8S rRNA (GO:0000460)3.18197392
120negative regulation of gene silencing (GO:0060969)3.18189542
121nodal signaling pathway (GO:0038092)3.18096997
122DNA replication-independent nucleosome assembly (GO:0006336)3.17844270
123DNA replication-independent nucleosome organization (GO:0034724)3.17844270
124oogenesis (GO:0048477)3.16523105
125telomere maintenance via recombination (GO:0000722)3.16280538
126positive regulation of chromosome segregation (GO:0051984)3.16085682
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15971190
128kinetochore organization (GO:0051383)3.15732269
129establishment of protein localization to mitochondrial membrane (GO:0090151)3.14805976
130histone exchange (GO:0043486)3.09217841
131transcription-coupled nucleotide-excision repair (GO:0006283)3.08773981
132male sex determination (GO:0030238)3.07009494
133embryonic body morphogenesis (GO:0010172)3.06486602
134regulation of spindle organization (GO:0090224)3.05941836
135establishment of viral latency (GO:0019043)3.04705431
136negative regulation of androgen receptor signaling pathway (GO:0060766)3.02376589
137mitotic recombination (GO:0006312)3.01601595
138anterior/posterior axis specification, embryo (GO:0008595)3.01211742
139regulation of translational fidelity (GO:0006450)3.00016200
140regulation of centrosome cycle (GO:0046605)2.99501457
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.99426994
142positive regulation of SMAD protein import into nucleus (GO:0060391)2.99206352
143ribosomal small subunit assembly (GO:0000028)2.98347098
144chaperone-mediated protein complex assembly (GO:0051131)2.98320253
145negative regulation of chromosome segregation (GO:0051985)2.98122111
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.95981431
147negative regulation of DNA recombination (GO:0045910)2.94840250
148mismatch repair (GO:0006298)2.93073549
149sister chromatid segregation (GO:0000819)2.91536686
150adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.89485341
151regulation of double-strand break repair via homologous recombination (GO:0010569)2.88816641
152mitotic chromosome condensation (GO:0007076)2.88124103
153folic acid metabolic process (GO:0046655)2.87244299
154RNA splicing, via transesterification reactions (GO:0000375)2.86278354
155regulation of mitotic spindle organization (GO:0060236)2.86275938
156regulation of telomere maintenance via telomerase (GO:0032210)2.85616746
157attachment of spindle microtubules to kinetochore (GO:0008608)2.85186389
158microtubule severing (GO:0051013)2.84739186
159acrosome assembly (GO:0001675)2.77953612
160histone H3-K36 demethylation (GO:0070544)2.76675795
161oocyte development (GO:0048599)2.75721695
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.75617986
163body morphogenesis (GO:0010171)2.74715118
164DNA methylation or demethylation (GO:0044728)2.73042205
165response to methylmercury (GO:0051597)2.71579383
166regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.66799400
167regulation of male gonad development (GO:2000018)2.66362729
168regulation of androgen receptor signaling pathway (GO:0060765)2.66278851
169ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.65795545
170regulation of microtubule-based movement (GO:0060632)2.63030074
171positive regulation of guanylate cyclase activity (GO:0031284)2.62230552
172positive regulation of potassium ion transmembrane transport (GO:1901381)2.61018438
173negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60768149
174inositol phosphate catabolic process (GO:0071545)2.56625322
175regulation of chromatin silencing (GO:0031935)2.55891265
176spermatid nucleus differentiation (GO:0007289)2.53845064
177positive regulation of mitochondrial fission (GO:0090141)2.53496095
178ncRNA 3-end processing (GO:0043628)2.52049952
179reproductive system development (GO:0061458)2.50310704
180anterograde axon cargo transport (GO:0008089)2.43472429
181regulation of chromatin binding (GO:0035561)2.42090187
182atrial cardiac muscle cell action potential (GO:0086014)2.41726998
183regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.40387566
184ionotropic glutamate receptor signaling pathway (GO:0035235)2.40092900
185startle response (GO:0001964)2.39832949
186sympathetic nervous system development (GO:0048485)2.39730647
187DNA modification (GO:0006304)2.38016983
188germ cell development (GO:0007281)2.36117947
189regulation of meiosis I (GO:0060631)11.1908912
190synapsis (GO:0007129)10.0488307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.56088971
2ZNF274_21170338_ChIP-Seq_K562_Hela4.69850915
3EZH2_22144423_ChIP-Seq_EOC_Human4.59519297
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.51782382
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.53221042
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.50439913
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16896639
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16215890
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99568102
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83052923
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82761452
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.79398771
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.79398771
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.79398771
15* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.71730770
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71191658
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.69089498
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.58603314
19RNF2_27304074_Chip-Seq_NSC_Mouse2.54966206
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.54368556
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48106489
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44080124
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43625469
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.39950171
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35941300
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.32617919
27IGF1R_20145208_ChIP-Seq_DFB_Human2.29553562
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28714794
29XRN2_22483619_ChIP-Seq_HELA_Human2.23611904
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19757251
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.19342424
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09316517
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.07579828
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06901747
35* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.06744805
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06252433
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04251361
38TCF3_18692474_ChIP-Seq_MEFs_Mouse2.03840383
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.02394937
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96393351
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92748991
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86083091
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83831461
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79861450
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.78430302
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.78384731
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77319898
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76692982
49AR_21909140_ChIP-Seq_LNCAP_Human1.76272749
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75621994
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.75584986
52VDR_23849224_ChIP-Seq_CD4+_Human1.75325334
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72591871
54TTF2_22483619_ChIP-Seq_HELA_Human1.67624506
55* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66591355
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.65922213
57DCP1A_22483619_ChIP-Seq_HELA_Human1.61933348
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.61851131
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60998334
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.60658749
61E2F1_17053090_ChIP-ChIP_MCF-7_Human1.60223872
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.59995826
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58877859
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58635336
65GABP_19822575_ChIP-Seq_HepG2_Human1.57562043
66FOXP3_21729870_ChIP-Seq_TREG_Human1.56902336
67GBX2_23144817_ChIP-Seq_PC3_Human1.55917185
68REST_21632747_ChIP-Seq_MESCs_Mouse1.54793870
69TP53_22573176_ChIP-Seq_HFKS_Human1.53843719
70* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.47672172
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46298807
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46022759
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44880066
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44122591
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42483701
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41956102
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39895200
78SOX9_26525672_Chip-Seq_HEART_Mouse1.39039503
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38797941
80EWS_26573619_Chip-Seq_HEK293_Human1.38592034
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.36922726
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36495937
83* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33665467
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33064653
85NCOR_22424771_ChIP-Seq_293T_Human1.32388124
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32312609
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.32077702
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32013900
89* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30872636
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29912579
91KDM5A_27292631_Chip-Seq_BREAST_Human1.29079657
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28832591
93POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28603289
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28096756
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25819286
96RUNX2_22187159_ChIP-Seq_PCA_Human1.24891014
97ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24706822
98* NANOG_21062744_ChIP-ChIP_HESCs_Human1.23766271
99WDR5_24793694_ChIP-Seq_LNCAP_Human1.23760801
100EGR1_19374776_ChIP-ChIP_THP-1_Human1.21508787
101STAT3_23295773_ChIP-Seq_U87_Human1.21376269
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20146869
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19370395
104* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17958961
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17794990
106CIITA_25753668_ChIP-Seq_RAJI_Human1.17402691
107* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16995926
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16972745
109NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16259253
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.15876348
111HTT_18923047_ChIP-ChIP_STHdh_Human1.15761115
112MYC_22102868_ChIP-Seq_BL_Human1.14597678
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13973466
114NOTCH1_21737748_ChIP-Seq_TLL_Human1.13709733
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12576718
116* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12278534
117ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12206333
118CBX2_27304074_Chip-Seq_ESCs_Mouse1.11860961
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11393364
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11022659
121FOXH1_21741376_ChIP-Seq_EPCs_Human1.11008999
122ELK1_19687146_ChIP-ChIP_HELA_Human1.10999782
123P300_19829295_ChIP-Seq_ESCs_Human1.10800035
124FUS_26573619_Chip-Seq_HEK293_Human1.09062220
125REST_19997604_ChIP-ChIP_NEURONS_Mouse1.08901187
126* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08412304
127ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08344792
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08035981
129MYC_18940864_ChIP-ChIP_HL60_Human1.07720272
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07565144
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07265729
132TCF4_23295773_ChIP-Seq_U87_Human1.06848308
133ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05710459
134DROSHA_22980978_ChIP-Seq_HELA_Human1.05637026
135MYC_19829295_ChIP-Seq_ESCs_Human1.05471387
136YY1_22570637_ChIP-Seq_MALME-3M_Human1.04331116
137SOX2_16153702_ChIP-ChIP_HESCs_Human1.03913939
138RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03219401
139TFEB_21752829_ChIP-Seq_HELA_Human1.01202463
140PHF8_20622854_ChIP-Seq_HELA_Human1.01190744
141* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00309880
142SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98289724
143STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97290509
144SRF_21415370_ChIP-Seq_HL-1_Mouse0.96896356
145CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96867015
146CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96796070
147ELF1_20517297_ChIP-Seq_JURKAT_Human0.95813518
148VDR_22108803_ChIP-Seq_LS180_Human0.95735940
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.95179392
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94273221
151OCT4_19829295_ChIP-Seq_ESCs_Human0.93243664
152* KAP1_27257070_Chip-Seq_ESCs_Mouse0.93183369
153FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92906413
154SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92888157
155TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92691210
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92414424
157SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92393770
158BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92237719
159AR_21572438_ChIP-Seq_LNCaP_Human0.91510137
160ZNF263_19887448_ChIP-Seq_K562_Human0.91373574
161POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91021588
162CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89316032
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88863191
164PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88745038
165CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88582245
166SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88371757
167AR_25329375_ChIP-Seq_VCAP_Human0.87864352
168KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87562898
169TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87327672
170SMAD4_21799915_ChIP-Seq_A2780_Human0.85599260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.05369468
2MP0004957_abnormal_blastocyst_morpholog4.63449399
3MP0003111_abnormal_nucleus_morphology4.21272793
4MP0010094_abnormal_chromosome_stability4.09965115
5MP0008057_abnormal_DNA_replication3.94641713
6MP0003077_abnormal_cell_cycle3.81794559
7MP0003183_abnormal_peptide_metabolism3.63604928
8MP0000569_abnormal_digit_pigmentation3.58215766
9MP0004133_heterotaxia3.23491822
10MP0001188_hyperpigmentation3.11190299
11MP0008058_abnormal_DNA_repair3.07481328
12MP0009840_abnormal_foam_cell2.99715582
13MP0003890_abnormal_embryonic-extraembry2.91623206
14MP0003806_abnormal_nucleotide_metabolis2.86576369
15MP0002163_abnormal_gland_morphology2.83351921
16MP0008877_abnormal_DNA_methylation2.82222741
17MP0001730_embryonic_growth_arrest2.69268919
18MP0003123_paternal_imprinting2.68420491
19MP0008932_abnormal_embryonic_tissue2.65795915
20MP0002653_abnormal_ependyma_morphology2.53128491
21MP0010352_gastrointestinal_tract_polyps2.50946642
22MP0006292_abnormal_olfactory_placode2.46033349
23MP0005174_abnormal_tail_pigmentation2.43754802
24MP0000350_abnormal_cell_proliferation2.37828579
25MP0003787_abnormal_imprinting2.35873859
26MP0010030_abnormal_orbit_morphology2.26408099
27MP0008007_abnormal_cellular_replicative2.26051882
28MP0000015_abnormal_ear_pigmentation2.23508975
29MP0005551_abnormal_eye_electrophysiolog2.20775259
30MP0002735_abnormal_chemical_nociception2.08946169
31MP0001672_abnormal_embryogenesis/_devel2.07469344
32MP0005380_embryogenesis_phenotype2.07469344
33MP0002085_abnormal_embryonic_tissue2.06182895
34MP0002084_abnormal_developmental_patter2.00815929
35MP0001697_abnormal_embryo_size2.00396095
36MP0003119_abnormal_digestive_system2.00091475
37MP0003718_maternal_effect1.96904600
38MP0004859_abnormal_synaptic_plasticity1.94376751
39MP0001293_anophthalmia1.92561949
40MP0000778_abnormal_nervous_system1.85329565
41MP0000427_abnormal_hair_cycle1.81172617
42MP0003984_embryonic_growth_retardation1.75600442
43MP0002088_abnormal_embryonic_growth/wei1.72398089
44MP0009046_muscle_twitch1.72178460
45MP0002080_prenatal_lethality1.69435932
46MP0002102_abnormal_ear_morphology1.67506223
47MP0002086_abnormal_extraembryonic_tissu1.65733072
48MP0003136_yellow_coat_color1.65279362
49MP0010307_abnormal_tumor_latency1.63471328
50MP0004270_analgesia1.62903389
51MP0003283_abnormal_digestive_organ1.61384102
52MP0002822_catalepsy1.59867756
53MP0004197_abnormal_fetal_growth/weight/1.57189102
54MP0009745_abnormal_behavioral_response1.53496518
55MP0003786_premature_aging1.53484329
56MP0004924_abnormal_behavior1.48085192
57MP0005386_behavior/neurological_phenoty1.48085192
58MP0001986_abnormal_taste_sensitivity1.46665811
59MP0005379_endocrine/exocrine_gland_phen1.46149497
60MP0005423_abnormal_somatic_nervous1.43455403
61MP0003941_abnormal_skin_development1.43208326
62MP0000751_myopathy1.42702774
63MP0003635_abnormal_synaptic_transmissio1.41975110
64MP0001919_abnormal_reproductive_system1.38383868
65MP0001968_abnormal_touch/_nociception1.34803595
66MP0001486_abnormal_startle_reflex1.30814481
67MP0006276_abnormal_autonomic_nervous1.29548402
68MP0005253_abnormal_eye_physiology1.26008083
69MP0000313_abnormal_cell_death1.25682182
70MP0003121_genomic_imprinting1.24776111
71MP0001502_abnormal_circadian_rhythm1.24469624
72MP0005076_abnormal_cell_differentiation1.24270844
73MP0002210_abnormal_sex_determination1.22430065
74MP0003567_abnormal_fetal_cardiomyocyte1.20509984
75MP0002272_abnormal_nervous_system1.19695291
76MP0001849_ear_inflammation1.15826619
77MP0002064_seizures1.15616272
78MP0001145_abnormal_male_reproductive1.15294595
79MP0002063_abnormal_learning/memory/cond1.15092246
80MP0004811_abnormal_neuron_physiology1.14953759
81MP0002736_abnormal_nociception_after1.14933759
82MP0003315_abnormal_perineum_morphology1.12191395
83MP0000537_abnormal_urethra_morphology1.11381566
84MP0002019_abnormal_tumor_incidence1.09940718
85MP0008872_abnormal_physiological_respon1.09093628
86MP0002882_abnormal_neuron_morphology1.05764650
87MP0002734_abnormal_mechanical_nocicepti1.05576920
88MP0002111_abnormal_tail_morphology1.05302668
89MP0002184_abnormal_innervation1.05090443
90MP0001984_abnormal_olfaction1.03349883
91MP0002229_neurodegeneration1.02240020
92MP0002572_abnormal_emotion/affect_behav1.01408547
93MP0001286_abnormal_eye_development1.00498219
94MP0000490_abnormal_crypts_of1.00133121
95MP0009672_abnormal_birth_weight0.98694860
96MP0003705_abnormal_hypodermis_morpholog0.98365385
97MP0005266_abnormal_metabolism0.97947308
98MP0000955_abnormal_spinal_cord0.97868309
99MP0000653_abnormal_sex_gland0.96264146
100MP0002067_abnormal_sensory_capabilities0.96134517
101MP0001929_abnormal_gametogenesis0.95813097
102MP0003937_abnormal_limbs/digits/tail_de0.95188236
103MP0003122_maternal_imprinting0.93799797
104MP0003861_abnormal_nervous_system0.92721910
105MP0000516_abnormal_urinary_system0.92024523
106MP0005367_renal/urinary_system_phenotyp0.92024523
107MP0003880_abnormal_central_pattern0.91901225
108MP0002249_abnormal_larynx_morphology0.91439035
109MP0009703_decreased_birth_body0.90909931
110MP0004142_abnormal_muscle_tone0.90662832
111MP0005195_abnormal_posterior_eye0.90559356
112MP0009379_abnormal_foot_pigmentation0.90280204
113MP0002160_abnormal_reproductive_system0.89803079
114MP0001970_abnormal_pain_threshold0.87704783
115MP0008789_abnormal_olfactory_epithelium0.87144508
116MP0000432_abnormal_head_morphology0.86642469
117MP0003699_abnormal_female_reproductive0.85353738
118MP0005084_abnormal_gallbladder_morpholo0.85083563
119MP0009053_abnormal_anal_canal0.84304283
120MP0001324_abnormal_eye_pigmentation0.83416858
121MP0010678_abnormal_skin_adnexa0.83171139
122MP0001485_abnormal_pinna_reflex0.81492277
123MP0005409_darkened_coat_color0.81491190
124MP0005394_taste/olfaction_phenotype0.81286300
125MP0005499_abnormal_olfactory_system0.81286300
126MP0000747_muscle_weakness0.81122413
127MP0002697_abnormal_eye_size0.79465159
128MP0002557_abnormal_social/conspecific_i0.79394621
129MP0003186_abnormal_redox_activity0.79248788
130MP0002092_abnormal_eye_morphology0.78594834
131MP0004742_abnormal_vestibular_system0.77333354
132MP0002095_abnormal_skin_pigmentation0.77261132
133MP0004043_abnormal_pH_regulation0.76261653
134MP0000358_abnormal_cell_content/0.76222157
135MP0005167_abnormal_blood-brain_barrier0.75583921
136MP0005410_abnormal_fertilization0.74987906
137MP0006072_abnormal_retinal_apoptosis0.74224126
138MP0005389_reproductive_system_phenotype0.71973464
139MP0005395_other_phenotype0.71608111
140MP0005391_vision/eye_phenotype0.71498580
141MP0002752_abnormal_somatic_nervous0.69978378
142MP0000383_abnormal_hair_follicle0.69928426
143MP0010234_abnormal_vibrissa_follicle0.69823640
144MP0004264_abnormal_extraembryonic_tissu0.69600135
145MP0002638_abnormal_pupillary_reflex0.69024014
146MP0002090_abnormal_vision0.68285659
147MP0002282_abnormal_trachea_morphology0.68078959
148MP0004233_abnormal_muscle_weight0.67700217
149MP0003936_abnormal_reproductive_system0.66686486
150MP0005384_cellular_phenotype0.66320897
151MP0001119_abnormal_female_reproductive0.65924371
152MP0005501_abnormal_skin_physiology0.65484859
153MP0003566_abnormal_cell_adhesion0.65392562
154MP0002152_abnormal_brain_morphology0.65274887
155MP0006035_abnormal_mitochondrial_morpho0.65221291
156MP0002751_abnormal_autonomic_nervous0.64017051
157MP0003943_abnormal_hepatobiliary_system0.63856081
158MP0008770_decreased_survivor_rate0.63840541
159MP0000428_abnormal_craniofacial_morphol0.63111851
160MP0000750_abnormal_muscle_regeneration0.63053236
161MP0000049_abnormal_middle_ear0.59605088
162MP0005621_abnormal_cell_physiology0.59378261
163MP0003755_abnormal_palate_morphology0.57980383
164MP0003935_abnormal_craniofacial_develop0.57835319
165MP0000678_abnormal_parathyroid_gland0.57699254
166MP0000762_abnormal_tongue_morphology0.56459544
167MP0000566_synostosis0.56147312
168MP0001915_intracranial_hemorrhage0.56074406
169MP0002161_abnormal_fertility/fecundity0.55787368
170MP0005023_abnormal_wound_healing0.55431125
171MP0002127_abnormal_cardiovascular_syste0.55427417
172MP0003698_abnormal_male_reproductive0.54478618

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.07187121
2Diastasis recti (HP:0001540)4.93847070
3Breast hypoplasia (HP:0003187)4.79168921
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.68692661
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.68692661
6Ependymoma (HP:0002888)4.64284129
7J-shaped sella turcica (HP:0002680)4.30579700
8Colon cancer (HP:0003003)4.22962168
9Abnormality of the labia minora (HP:0012880)4.05332157
10Abnormality of the corticospinal tract (HP:0002492)4.02862164
11Supernumerary spleens (HP:0009799)3.99476923
12Medulloblastoma (HP:0002885)3.82815612
13Absent radius (HP:0003974)3.68980046
14Abdominal situs inversus (HP:0003363)3.63117383
15Abnormality of abdominal situs (HP:0011620)3.63117383
16Selective tooth agenesis (HP:0001592)3.61718182
17Oral leukoplakia (HP:0002745)3.60983901
18Vertebral arch anomaly (HP:0008438)3.58335939
19Reticulocytopenia (HP:0001896)3.54587210
20Type II lissencephaly (HP:0007260)3.50819009
21Aplasia involving forearm bones (HP:0009822)3.46656044
22Absent forearm bone (HP:0003953)3.46656044
23Fair hair (HP:0002286)3.46187342
24Abnormality of the lower motor neuron (HP:0002366)3.45592611
25Horizontal nystagmus (HP:0000666)3.43527725
26Oligodactyly (hands) (HP:0001180)3.43286753
27Retinal dysplasia (HP:0007973)3.39640953
28Volvulus (HP:0002580)3.34390380
29Focal motor seizures (HP:0011153)3.33748026
30Rhabdomyosarcoma (HP:0002859)3.32701814
31Patellar aplasia (HP:0006443)3.32201519
32Shoulder girdle muscle weakness (HP:0003547)3.31168912
33Amyotrophic lateral sclerosis (HP:0007354)3.28869891
34Hip dysplasia (HP:0001385)3.25824086
35Absent thumb (HP:0009777)3.25224149
36Abnormality of the lumbar spine (HP:0100712)3.24368970
37Carpal bone hypoplasia (HP:0001498)3.22936067
38Lissencephaly (HP:0001339)3.22388396
39Astrocytoma (HP:0009592)3.21791051
40Abnormality of the astrocytes (HP:0100707)3.21791051
41Agnosia (HP:0010524)3.20920438
42Neoplasm of the oral cavity (HP:0100649)3.17019692
43Rib fusion (HP:0000902)3.08260718
44Gaze-evoked nystagmus (HP:0000640)3.06941029
45Chromsome breakage (HP:0040012)3.05097109
46Aplasia/hypoplasia of the humerus (HP:0006507)3.04016562
47Aplasia/Hypoplasia of the patella (HP:0006498)3.02482866
48Rimmed vacuoles (HP:0003805)3.02454084
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98752978
50Impaired vibration sensation in the lower limbs (HP:0002166)2.90675617
51Abnormality of macular pigmentation (HP:0008002)2.90514879
52Rectal fistula (HP:0100590)2.90495614
53Rectovaginal fistula (HP:0000143)2.90495614
54Rough bone trabeculation (HP:0100670)2.87610476
553-Methylglutaconic aciduria (HP:0003535)2.87115149
56Abnormal number of incisors (HP:0011064)2.85994031
57Neoplasm of striated muscle (HP:0009728)2.80562195
58Severe visual impairment (HP:0001141)2.77400092
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.77094972
60Cerebral hypomyelination (HP:0006808)2.73296216
61Duplicated collecting system (HP:0000081)2.73040519
62Severe Myopia (HP:0011003)2.71730072
63Short humerus (HP:0005792)2.70408758
64Stenosis of the external auditory canal (HP:0000402)2.68476111
65Glioma (HP:0009733)2.65385651
66Impulsivity (HP:0100710)2.65004119
67Trismus (HP:0000211)2.64311138
68Pendular nystagmus (HP:0012043)2.63578906
69Abnormality of the alveolar ridges (HP:0006477)2.62081561
70Abnormality of cells of the erythroid lineage (HP:0012130)2.60363133
71Broad alveolar ridges (HP:0000187)2.59873260
72Asplenia (HP:0001746)2.56906006
73Missing ribs (HP:0000921)2.55929329
74Degeneration of anterior horn cells (HP:0002398)2.55114219
75Abnormality of the anterior horn cell (HP:0006802)2.55114219
76Osteomalacia (HP:0002749)2.54105961
77Intestinal fistula (HP:0100819)2.51385220
78Horseshoe kidney (HP:0000085)2.50130464
79Azoospermia (HP:0000027)2.49084355
80Ectopic kidney (HP:0000086)2.49053946
8111 pairs of ribs (HP:0000878)2.48960083
82Fibular aplasia (HP:0002990)2.48793664
83Shawl scrotum (HP:0000049)2.46244164
84Breast aplasia (HP:0100783)2.43759220
85Neoplasm of the pancreas (HP:0002894)2.42952512
86Cellular immunodeficiency (HP:0005374)2.42283168
87Esophageal atresia (HP:0002032)2.41294284
88Urinary bladder sphincter dysfunction (HP:0002839)2.40932022
89Vaginal fistula (HP:0004320)2.40875089
90Abnormality of pyrimidine metabolism (HP:0004353)2.40017404
91Thoracic kyphosis (HP:0002942)2.39902201
92Meckel diverticulum (HP:0002245)2.38819175
93Abnormality of the preputium (HP:0100587)2.38364115
94Neonatal short-limb short stature (HP:0008921)2.38074327
95Abnormality of the ileum (HP:0001549)2.37840819
96Supernumerary bones of the axial skeleton (HP:0009144)2.37221501
97Basal cell carcinoma (HP:0002671)2.36822412
98Tracheoesophageal fistula (HP:0002575)2.36727801
99Premature graying of hair (HP:0002216)2.36621200
100Multiple enchondromatosis (HP:0005701)2.36382098
101Conjugated hyperbilirubinemia (HP:0002908)2.35887158
102Macrocytic anemia (HP:0001972)2.35050747
103Aplasia/Hypoplasia of the spleen (HP:0010451)2.34045639
104Abnormality of the renal cortex (HP:0011035)2.34031194
105Wide intermamillary distance (HP:0006610)2.30609515
106Premature ovarian failure (HP:0008209)2.28269326
107Aplasia/Hypoplasia of the uvula (HP:0010293)2.26839417
108Aplasia/Hypoplasia of the breasts (HP:0010311)2.26051588
109Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.25166841
110Abnormality of the renal collecting system (HP:0004742)2.24755434
111Biliary tract neoplasm (HP:0100574)2.21823426
112Abnormality of chromosome stability (HP:0003220)2.20613460
113Septo-optic dysplasia (HP:0100842)2.17809941
114Generalized hypopigmentation of hair (HP:0011358)2.17281014
115Deformed sella turcica (HP:0002681)2.17022468
116Atresia of the external auditory canal (HP:0000413)2.16888278
117Atrophy/Degeneration involving motor neurons (HP:0007373)2.16547585
118Truncal obesity (HP:0001956)2.14993390
119Aortic regurgitation (HP:0001659)2.13948370
120Beaking of vertebral bodies (HP:0004568)2.13136382
121Abnormality of the salivary glands (HP:0010286)2.12790178
122Renal cortical cysts (HP:0000803)2.12659711
123Hypoplasia of the radius (HP:0002984)2.11901999
124Macroglossia (HP:0000158)2.11685098
125Urinary urgency (HP:0000012)2.11682936
126Amblyopia (HP:0000646)2.11183629
127Abnormality of the vocal cords (HP:0008777)2.10174232
128Myokymia (HP:0002411)2.09229032
129Abnormal trabecular bone morphology (HP:0100671)2.07448309
130Sex reversal (HP:0012245)2.06664792
131Abnormal sex determination (HP:0012244)2.06664792
132Abnormal lung lobation (HP:0002101)2.06582590
133Oligodactyly (HP:0012165)2.05781745
134Steppage gait (HP:0003376)2.04640250
135Abnormal number of erythroid precursors (HP:0012131)2.04467665
136Cleft eyelid (HP:0000625)2.04436771
137Aplasia/Hypoplasia of the sternum (HP:0006714)2.04054757
138Nephronophthisis (HP:0000090)2.03924555
139Supernumerary ribs (HP:0005815)2.03913108
140Short thumb (HP:0009778)2.03802698
141Pachygyria (HP:0001302)2.02735173
142Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01692131
143Facial hemangioma (HP:0000329)2.00553010
144Gonadotropin excess (HP:0000837)2.00054947
145Protruding tongue (HP:0010808)2.00021994
146Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.97668197
147Epileptic encephalopathy (HP:0200134)1.97559056
148Abnormality of chromosome segregation (HP:0002916)1.97526705
149Abnormality of the thoracic spine (HP:0100711)1.97305437
150Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.96637395
151Villous atrophy (HP:0011473)1.95706438
152Abnormality of small intestinal villus morphology (HP:0011472)1.95706438
153Spinal muscular atrophy (HP:0007269)1.94460014
154Focal seizures (HP:0007359)1.93398116
155Gastrointestinal atresia (HP:0002589)1.93351170
156Triphalangeal thumb (HP:0001199)1.93012835
157Hemivertebrae (HP:0002937)1.92330801
158Angiofibromas (HP:0010615)1.90944105
159Adenoma sebaceum (HP:0009720)1.90944105
160Facial cleft (HP:0002006)1.90107172
161Myelodysplasia (HP:0002863)1.89691681
162High anterior hairline (HP:0009890)1.87923817
163Intellectual disability, profound (HP:0002187)1.87906511
164Intestinal atresia (HP:0011100)1.87759878
165Small hand (HP:0200055)1.87474381
166Sloping forehead (HP:0000340)1.87373820
167Spastic gait (HP:0002064)1.86726764
168Anal stenosis (HP:0002025)1.86697813
169Pallor (HP:0000980)1.86441708
170Squamous cell carcinoma (HP:0002860)1.86413917
171Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85612597
172Abnormality of the renal medulla (HP:0100957)1.85531182
173Clitoromegaly (HP:0000057)1.84265793
174Hypobetalipoproteinemia (HP:0003563)1.82772811
175Thoracolumbar scoliosis (HP:0002944)1.81136759
176Bicornuate uterus (HP:0000813)1.81075313
177Tetany (HP:0001281)1.79206206
178Morphological abnormality of the pyramidal tract (HP:0002062)1.79150867
179Tubular atrophy (HP:0000092)1.78315731
180Broad ribs (HP:0000885)1.77302688
181Impaired vibratory sensation (HP:0002495)1.76634776
182Hoarse voice (HP:0001609)1.76501976
183Neoplasm of the adrenal cortex (HP:0100641)1.76280713
184Poor eye contact (HP:0000817)1.75412674
185Hyperphosphatemia (HP:0002905)1.73683787
186Spontaneous abortion (HP:0005268)1.73070556
187Upper motor neuron abnormality (HP:0002127)1.71871057
188Enlarged penis (HP:0000040)1.71838047
189Prolonged QT interval (HP:0001657)1.70160389
190Polyphagia (HP:0002591)1.70095478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59827688
2CDC74.33512615
3WEE14.30232595
4CDK194.03914540
5MARK13.95050896
6CAMK1G3.32852315
7TTK3.00408344
8CDK122.99330590
9NTRK32.95600917
10NEK12.79060818
11EPHA22.60768903
12EIF2AK12.60027796
13CAMKK22.37198947
14NEK22.36856098
15CDK72.31550268
16PLK12.19178931
17SRPK12.14934990
18TSSK62.08724395
19INSRR2.07317538
20PNCK2.01558448
21EPHA42.00478799
22LATS21.99733598
23RPS6KB21.92711022
24MAP3K121.87281226
25TESK21.73807920
26NUAK11.70842896
27OXSR11.67088886
28STK38L1.65585831
29CHEK21.65442301
30YES11.63686644
31MAP2K61.62931300
32DYRK31.61973343
33ATR1.60666696
34PLK31.59491995
35AURKB1.58271623
36PLK41.57861548
37AURKA1.53397586
38MINK11.52995200
39MAP3K81.48072161
40PASK1.46538640
41VRK11.45701599
42CHEK11.44581199
43MUSK1.43450206
44NME21.33419808
45BCR1.32012604
46STK101.28647424
47TRIM281.26943459
48PAK41.26602464
49SIK21.26202913
50TLK11.25764545
51ALK1.25539154
52CAMK11.25121697
53PTK2B1.24189588
54EIF2AK31.23721974
55LATS11.18929383
56BRD41.14795647
57MKNK11.14671101
58CDK41.14538058
59AKT31.10157211
60BMX1.08493415
61CDK21.07765594
62BMPR1B1.02653629
63BRSK21.01995336
64BCKDK1.01670903
65ATM1.01603463
66ZAK1.00352302
67DYRK21.00207189
68DYRK1A0.99712174
69CAMKK10.99332419
70FLT30.98080801
71MKNK20.97950909
72ACVR1B0.97377783
73RPS6KA40.92834560
74MAPKAPK30.92262549
75ERBB40.92144231
76PRKCI0.91938270
77BRAF0.89537823
78ICK0.89276848
79CSNK2A20.88448229
80WNK30.87303287
81PIK3CG0.86442613
82CDK50.86027248
83SCYL20.84592758
84MAP3K110.83348602
85MELK0.78345336
86CSNK1E0.76285504
87KSR10.75134723
88CDK60.75001892
89FGR0.73373776
90CDK10.73256926
91PDGFRB0.73102073
92STK40.72850789
93PAK10.71943413
94MTOR0.71124494
95PRKCG0.70152712
96PBK0.69281765
97CSNK2A10.68943031
98CAMK40.68460742
99PIM10.67906480
100GRK60.67780097
101CDK30.66774746
102MAP3K90.64565457
103BRSK10.63262368
104FRK0.60975627
105NEK90.60728776
106CSNK1G20.58513800
107MAP3K40.57388265
108CDK11A0.55801079
109TYRO30.54832177
110FGFR10.54167946
111AKT20.53866403
112MAP3K100.53612315
113MAP3K60.52583024
114STK380.51618951
115CDK180.50375718
116PINK10.48505517
117CSNK1D0.48217883
118CSF1R0.48189379
119MAP2K40.48144100
120RET0.47465432
121PDK20.47218676
122CDK150.46731132
123MET0.46589802
124ABL20.45811453
125DAPK10.45181361
126EEF2K0.43224206
127PRKDC0.43163241
128SGK10.42263372
129CAMK2A0.41719476
130TGFBR10.41111693
131CCNB10.40724573
132MAPK130.40444728
133PRKCZ0.40310223
134PDK40.38994923
135PDK30.38994923
136CDK140.38028215
137MAP2K30.35250550
138MAPK150.35235572
139MAPK140.33263268
140STK160.33223054
141KSR20.32901424
142SIK30.32850868
143GSK3B0.32404303
144EIF2AK20.31397775
145DDR20.29834725
146MST40.28480045
147RPS6KA50.28136204
148MAPK100.27540705
149PKN20.27467674
150FER0.27305242
151RPS6KA30.26654244
152RPS6KA10.26650017
153EGFR0.25954629
154AKT10.25825632
155MAPK10.25480890
156PRKACB0.25125422
157STK30.24725278
158ROCK10.23787399
159PRKG10.22507266
160MAP3K50.22249832
161MAPK80.21921480
162WNK40.20528063
163PTK20.20102741
164NTRK20.19856502
165CASK0.19684068

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.59191753
2Mismatch repair_Homo sapiens_hsa034304.57035377
3Phototransduction_Homo sapiens_hsa047444.35386424
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.28189696
5RNA polymerase_Homo sapiens_hsa030203.79926882
6Ribosome_Homo sapiens_hsa030103.65601703
7Spliceosome_Homo sapiens_hsa030403.61952359
8RNA transport_Homo sapiens_hsa030133.49338294
9One carbon pool by folate_Homo sapiens_hsa006703.17445039
10Proteasome_Homo sapiens_hsa030502.91669431
11Base excision repair_Homo sapiens_hsa034102.84968828
12Homologous recombination_Homo sapiens_hsa034402.79776935
13Nucleotide excision repair_Homo sapiens_hsa034202.77925544
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.75493779
15Pyrimidine metabolism_Homo sapiens_hsa002402.47397859
16Cell cycle_Homo sapiens_hsa041102.44066329
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.42774956
18Fanconi anemia pathway_Homo sapiens_hsa034602.21894280
19Nicotine addiction_Homo sapiens_hsa050332.15015545
20RNA degradation_Homo sapiens_hsa030182.11972827
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07600722
22mRNA surveillance pathway_Homo sapiens_hsa030152.04353759
23Basal transcription factors_Homo sapiens_hsa030221.95212859
24Protein export_Homo sapiens_hsa030601.81977566
25Non-homologous end-joining_Homo sapiens_hsa034501.77609811
26Regulation of autophagy_Homo sapiens_hsa041401.63107085
27Circadian rhythm_Homo sapiens_hsa047101.60167400
28Cocaine addiction_Homo sapiens_hsa050301.56265426
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.52058997
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44795822
31Biosynthesis of amino acids_Homo sapiens_hsa012301.44109965
32p53 signaling pathway_Homo sapiens_hsa041151.39243596
33Dorso-ventral axis formation_Homo sapiens_hsa043201.30166276
34Vitamin digestion and absorption_Homo sapiens_hsa049771.29339347
35Purine metabolism_Homo sapiens_hsa002301.25329399
36Glutamatergic synapse_Homo sapiens_hsa047241.22471248
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.18008130
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15453489
39Steroid biosynthesis_Homo sapiens_hsa001001.12206600
40Dopaminergic synapse_Homo sapiens_hsa047281.11831310
41Oocyte meiosis_Homo sapiens_hsa041141.09424265
42Fatty acid elongation_Homo sapiens_hsa000621.07948085
43Ether lipid metabolism_Homo sapiens_hsa005651.07894894
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.07028423
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.05325894
46Folate biosynthesis_Homo sapiens_hsa007901.04631553
47Amphetamine addiction_Homo sapiens_hsa050311.04073656
48Insulin secretion_Homo sapiens_hsa049111.03685832
49Epstein-Barr virus infection_Homo sapiens_hsa051691.03203460
50Morphine addiction_Homo sapiens_hsa050320.99514857
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98572410
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98463887
53Circadian entrainment_Homo sapiens_hsa047130.97973705
54Olfactory transduction_Homo sapiens_hsa047400.96456525
55Propanoate metabolism_Homo sapiens_hsa006400.94956133
56Synaptic vesicle cycle_Homo sapiens_hsa047210.94497604
57Selenocompound metabolism_Homo sapiens_hsa004500.93553544
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92486334
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91716700
60Axon guidance_Homo sapiens_hsa043600.89700682
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89332252
62Butanoate metabolism_Homo sapiens_hsa006500.87260034
63Basal cell carcinoma_Homo sapiens_hsa052170.86552737
64Fatty acid metabolism_Homo sapiens_hsa012120.85437727
65Sulfur relay system_Homo sapiens_hsa041220.83919734
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82335708
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81958840
68Hippo signaling pathway_Homo sapiens_hsa043900.81590851
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80305398
70Thyroid cancer_Homo sapiens_hsa052160.79577308
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79532165
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79412818
73Systemic lupus erythematosus_Homo sapiens_hsa053220.78326268
74TGF-beta signaling pathway_Homo sapiens_hsa043500.78248260
75Calcium signaling pathway_Homo sapiens_hsa040200.77323048
76Taste transduction_Homo sapiens_hsa047420.76498929
77Ovarian steroidogenesis_Homo sapiens_hsa049130.75653637
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72457262
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.72376517
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72277435
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69029022
82GABAergic synapse_Homo sapiens_hsa047270.68569064
83Viral carcinogenesis_Homo sapiens_hsa052030.66497758
84Carbon metabolism_Homo sapiens_hsa012000.66422940
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66259106
86Fructose and mannose metabolism_Homo sapiens_hsa000510.65046877
87Huntingtons disease_Homo sapiens_hsa050160.63529639
88Glutathione metabolism_Homo sapiens_hsa004800.63336088
89MicroRNAs in cancer_Homo sapiens_hsa052060.62721528
90ErbB signaling pathway_Homo sapiens_hsa040120.62167977
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62164172
92Ras signaling pathway_Homo sapiens_hsa040140.60221452
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58230418
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56775393
95Sphingolipid metabolism_Homo sapiens_hsa006000.55664917
96Hedgehog signaling pathway_Homo sapiens_hsa043400.55622123
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.54045630
98Notch signaling pathway_Homo sapiens_hsa043300.51782972
99Arginine and proline metabolism_Homo sapiens_hsa003300.51235105
100Pentose phosphate pathway_Homo sapiens_hsa000300.50720172
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50590091
102Cholinergic synapse_Homo sapiens_hsa047250.50431101
103Fatty acid biosynthesis_Homo sapiens_hsa000610.50074623
104Fatty acid degradation_Homo sapiens_hsa000710.49338473
105Retinol metabolism_Homo sapiens_hsa008300.49038525
106Long-term depression_Homo sapiens_hsa047300.48670887
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48662094
108Herpes simplex infection_Homo sapiens_hsa051680.47892289
109Collecting duct acid secretion_Homo sapiens_hsa049660.47518995
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.46655500
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44987234
112Glycerolipid metabolism_Homo sapiens_hsa005610.44318980
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43761704
114HTLV-I infection_Homo sapiens_hsa051660.43328172
115Bladder cancer_Homo sapiens_hsa052190.42213143
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40290745
117PPAR signaling pathway_Homo sapiens_hsa033200.39730362
118Tight junction_Homo sapiens_hsa045300.37891267
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37161212
120Adherens junction_Homo sapiens_hsa045200.37063073
121MAPK signaling pathway_Homo sapiens_hsa040100.36662824
122Long-term potentiation_Homo sapiens_hsa047200.36491137
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36153777
124Fat digestion and absorption_Homo sapiens_hsa049750.35906110
125Cardiac muscle contraction_Homo sapiens_hsa042600.34316762
126Bile secretion_Homo sapiens_hsa049760.34132678
127Colorectal cancer_Homo sapiens_hsa052100.33970700
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33740049
129mTOR signaling pathway_Homo sapiens_hsa041500.33469040
130Wnt signaling pathway_Homo sapiens_hsa043100.33291980
131HIF-1 signaling pathway_Homo sapiens_hsa040660.28647088
132Vitamin B6 metabolism_Homo sapiens_hsa007500.28608797
133Galactose metabolism_Homo sapiens_hsa000520.28436766
134Linoleic acid metabolism_Homo sapiens_hsa005910.26427592
135Pathways in cancer_Homo sapiens_hsa052000.26123507
136Antigen processing and presentation_Homo sapiens_hsa046120.24778009
137Phenylalanine metabolism_Homo sapiens_hsa003600.24343261
138Small cell lung cancer_Homo sapiens_hsa052220.23559042
139Melanoma_Homo sapiens_hsa052180.23347608
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22604520
141Metabolic pathways_Homo sapiens_hsa011000.22020229
142Pyruvate metabolism_Homo sapiens_hsa006200.21473437
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21466473
144Alcoholism_Homo sapiens_hsa050340.21419798
145Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19769859
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17500492
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15551261
148Lysine degradation_Homo sapiens_hsa003100.15534565
149Parkinsons disease_Homo sapiens_hsa050120.13864258
150Tyrosine metabolism_Homo sapiens_hsa003500.13091305
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11934901
152Arachidonic acid metabolism_Homo sapiens_hsa005900.08516157
153Prostate cancer_Homo sapiens_hsa052150.06980967
154Apoptosis_Homo sapiens_hsa042100.06311433
155Legionellosis_Homo sapiens_hsa051340.04607603
156Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.03845735
157Arginine biosynthesis_Homo sapiens_hsa002200.03556642
158Oxidative phosphorylation_Homo sapiens_hsa001900.03118359
159Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02843631
160Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.01569912
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.01401288
162Acute myeloid leukemia_Homo sapiens_hsa052210.00537142
163Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0074139
164PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0031593

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