EPYC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dermatan sulfate proteoglycan 3 is a member of the small leucine-rich repeat proteoglycan family. This gene is composed of seven exons. It regulates fibrillogenesis by interacting with collagen fibrils and other extracellular matrix proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-proline hydroxylation (GO:0019511)9.73336533
2GMP metabolic process (GO:0046037)9.50718273
3keratan sulfate catabolic process (GO:0042340)7.76381730
4positive regulation of epidermal cell differentiation (GO:0045606)7.68182695
5chondrocyte development (GO:0002063)7.55937595
6protein localization to cell surface (GO:0034394)7.47728608
7protein hydroxylation (GO:0018126)7.29094710
8positive regulation of receptor internalization (GO:0002092)6.95052889
9notochord development (GO:0030903)6.93062530
10positive regulation of extracellular matrix organization (GO:1903055)6.59579178
11collagen fibril organization (GO:0030199)6.50468269
12negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)6.25565724
13limb bud formation (GO:0060174)6.23407943
14otic vesicle formation (GO:0030916)6.23353497
15decidualization (GO:0046697)6.07151744
16regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 6.07040052
17lipopolysaccharide biosynthetic process (GO:0009103)5.85158556
18collagen catabolic process (GO:0030574)5.83613518
19diterpenoid biosynthetic process (GO:0016102)5.82925422
20regulation of extracellular matrix disassembly (GO:0010715)5.73586154
21positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr5.65485535
22collagen metabolic process (GO:0032963)5.59465795
23purine nucleotide salvage (GO:0032261)5.42870304
24cartilage development (GO:0051216)5.41331033
25branching involved in salivary gland morphogenesis (GO:0060445)5.36434884
26multicellular organismal catabolic process (GO:0044243)5.34650615
27bone trabecula formation (GO:0060346)5.31285522
28multicellular organismal macromolecule metabolic process (GO:0044259)5.22665111
29muscle cell fate commitment (GO:0042693)5.12415959
30embryonic skeletal joint morphogenesis (GO:0060272)5.08228646
31mesonephros development (GO:0001823)5.05341759
32radial glial cell differentiation (GO:0060019)5.02999860
33regulation of keratinocyte proliferation (GO:0010837)4.99219560
34lipopolysaccharide metabolic process (GO:0008653)4.95261238
35multicellular organismal metabolic process (GO:0044236)4.93214723
36glycoprotein catabolic process (GO:0006516)4.91789665
37toxin metabolic process (GO:0009404)4.83953892
38protein retention in ER lumen (GO:0006621)4.77042933
39chondrocyte differentiation (GO:0002062)4.75239462
40response to hepatocyte growth factor (GO:0035728)4.72651004
41cellular response to hepatocyte growth factor stimulus (GO:0035729)4.72651004
42mesenchymal cell proliferation (GO:0010463)4.63834437
43proteoglycan metabolic process (GO:0006029)4.62330482
44negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.59822989
45detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.55845728
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.55399359
47endothelial cell morphogenesis (GO:0001886)4.48650651
48regulation of receptor internalization (GO:0002090)4.45806402
49terpenoid biosynthetic process (GO:0016114)4.44502392
50purine-containing compound salvage (GO:0043101)4.41137132
51positive chemotaxis (GO:0050918)4.40876675
52auditory receptor cell differentiation (GO:0042491)4.40865812
53sensory perception of sound (GO:0007605)4.40455834
54cochlea morphogenesis (GO:0090103)4.38878653
55white fat cell differentiation (GO:0050872)4.33216898
56sensory perception of mechanical stimulus (GO:0050954)4.31923801
57regulation of extracellular matrix organization (GO:1903053)4.31746297
58positive regulation of epidermis development (GO:0045684)4.28558823
59iron ion import (GO:0097286)4.27839022
60extracellular matrix disassembly (GO:0022617)4.27032004
61platelet-derived growth factor receptor signaling pathway (GO:0048008)4.26645976
62endocardial cushion morphogenesis (GO:0003203)4.26020002
63lung epithelium development (GO:0060428)4.24793150
64IMP biosynthetic process (GO:0006188)4.10966047
65regulation of alkaline phosphatase activity (GO:0010692)4.10267009
66lung secretory cell differentiation (GO:0061140)4.09753364
67negative regulation of stress-activated MAPK cascade (GO:0032873)4.07864767
68negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)4.07864767
69keratan sulfate biosynthetic process (GO:0018146)4.07488667
70regulation of secondary heart field cardioblast proliferation (GO:0003266)4.06885676
71regulation of cardioblast proliferation (GO:0003264)4.06885676
72genitalia morphogenesis (GO:0035112)4.05459555
73regulation of plasminogen activation (GO:0010755)4.04823267
74kidney morphogenesis (GO:0060993)4.02333750
75branch elongation of an epithelium (GO:0060602)3.99855357
76mesenchyme morphogenesis (GO:0072132)3.98984843
77glomerular basement membrane development (GO:0032836)3.98690604
78positive regulation of osteoblast proliferation (GO:0033690)3.97258089
79retinal metabolic process (GO:0042574)3.95418572
80regulation of odontogenesis (GO:0042481)3.93941675
81regulation of heart morphogenesis (GO:2000826)3.93471075
82regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.91304159
83righting reflex (GO:0060013)3.88394468
84endochondral ossification (GO:0001958)3.86987267
85replacement ossification (GO:0036075)3.86987267
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.86682417
87negative regulation of JNK cascade (GO:0046329)3.84523213
88type B pancreatic cell proliferation (GO:0044342)3.82116814
89bone resorption (GO:0045453)3.81003924
90glycoprotein metabolic process (GO:0009100)3.80251783
91type B pancreatic cell development (GO:0003323)3.78893173
92nucleotide salvage (GO:0043173)3.78624639
93negative regulation of complement activation (GO:0045916)3.75803444
94nephron tubule formation (GO:0072079)3.75073718
95organ induction (GO:0001759)3.74131165
96photoreceptor cell differentiation (GO:0046530)3.70976143
97eye photoreceptor cell differentiation (GO:0001754)3.70976143
98glial cell migration (GO:0008347)3.68804752
99keratinocyte proliferation (GO:0043616)3.67279467
100skeletal system development (GO:0001501)3.65438759
101positive regulation of DNA repair (GO:0045739)3.63396309
102Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.61569147
103face morphogenesis (GO:0060325)3.58815978
104negative regulation of fatty acid transport (GO:2000192)3.58229688
105sphingomyelin metabolic process (GO:0006684)3.57811611
106regulation of transforming growth factor beta2 production (GO:0032909)3.56772215
107positive regulation of receptor-mediated endocytosis (GO:0048260)3.56438860
108tooth mineralization (GO:0034505)3.55978198
109metanephric mesenchyme development (GO:0072075)3.55464511
110positive regulation of hormone biosynthetic process (GO:0046886)3.55398201
111nucleoside salvage (GO:0043174)3.54767110
112negative regulation of chondrocyte differentiation (GO:0032331)3.52503427
113inner ear morphogenesis (GO:0042472)3.51565426
114connective tissue development (GO:0061448)3.50843100
115face development (GO:0060324)3.50282726
116vasculature development (GO:0001944)3.46976751
117regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.46038850
118negative regulation of cartilage development (GO:0061037)3.45882938
119hair follicle morphogenesis (GO:0031069)3.44967805
120chondroitin sulfate biosynthetic process (GO:0030206)3.43947645
121IMP metabolic process (GO:0046040)3.41752843
122keratan sulfate metabolic process (GO:0042339)3.40593040
123negative regulation of catenin import into nucleus (GO:0035414)3.38641703
124positive regulation of cartilage development (GO:0061036)3.38159009
125hypotonic response (GO:0006971)3.37535557
126regulation of establishment of planar polarity (GO:0090175)3.35176209
127regulation of fatty acid beta-oxidation (GO:0031998)3.34963492
128skin morphogenesis (GO:0043589)3.34108775
129regulation of mesenchymal cell apoptotic process (GO:2001053)3.33862796
130negative regulation of protein activation cascade (GO:2000258)3.33152925
131transmission of nerve impulse (GO:0019226)3.32791485
132positive regulation of chondrocyte differentiation (GO:0032332)3.31942413
133sulfur compound catabolic process (GO:0044273)3.28737173
134negative regulation of biomineral tissue development (GO:0070168)3.28075671
135positive regulation of canonical Wnt signaling pathway (GO:0090263)3.27399442
136regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.27375171
137dorsal/ventral axis specification (GO:0009950)3.24953903
138regulation of female gonad development (GO:2000194)3.24744830
139regulation of chondrocyte differentiation (GO:0032330)3.21799334
140purine nucleobase biosynthetic process (GO:0009113)3.19852864
141inner ear receptor cell differentiation (GO:0060113)3.18803818
142regulation of response to reactive oxygen species (GO:1901031)3.17351266
143primary amino compound metabolic process (GO:1901160)3.15929473
144response to BMP (GO:0071772)3.15085753
145cellular response to BMP stimulus (GO:0071773)3.15085753
146cellular glucuronidation (GO:0052695)3.14655713
147regulation of macrophage cytokine production (GO:0010935)3.14483428
148regulation of energy homeostasis (GO:2000505)3.13474308
149regulation of cartilage development (GO:0061035)3.12697675
150actin cytoskeleton reorganization (GO:0031532)3.12473994
151short-term memory (GO:0007614)3.12154394
152ossification (GO:0001503)3.09001478
153extracellular matrix organization (GO:0030198)3.07862013
154extracellular structure organization (GO:0043062)3.07096131
155embryonic camera-type eye development (GO:0031076)3.06004885
156positive regulation of endothelial cell differentiation (GO:0045603)3.05969005
157kidney mesenchyme development (GO:0072074)3.04914522
158non-canonical Wnt signaling pathway (GO:0035567)3.04381991
159nucleotide-sugar biosynthetic process (GO:0009226)2.99892296
160establishment of tissue polarity (GO:0007164)2.97883799
161establishment of planar polarity (GO:0001736)2.97883799
162negative regulation of gluconeogenesis (GO:0045721)2.97486742
163COPI coating of Golgi vesicle (GO:0048205)2.97437197
164Golgi transport vesicle coating (GO:0048200)2.97437197
165glucuronate metabolic process (GO:0019585)2.96528945
166uronic acid metabolic process (GO:0006063)2.96528945
167reflex (GO:0060004)2.95730616
168diaphragm development (GO:0060539)2.94869896
169regulation of organ formation (GO:0003156)2.94550986
170induction of positive chemotaxis (GO:0050930)2.93354181
171lateral sprouting from an epithelium (GO:0060601)2.92723482
172glandular epithelial cell development (GO:0002068)2.91622519
173negative regulation of humoral immune response (GO:0002921)2.91219082
174regulation of steroid hormone biosynthetic process (GO:0090030)2.90962372
175protein heterotrimerization (GO:0070208)2.88058920
176negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.83933204
177mesenchymal-epithelial cell signaling (GO:0060638)15.6014541
178regulation of branching involved in salivary gland morphogenesis (GO:0060693)12.8652114
179cell aggregation (GO:0098743)11.5723313
180cartilage condensation (GO:0001502)11.5723313
181cartilage development involved in endochondral bone morphogenesis (GO:0060351)11.0882086
182phosphate ion homeostasis (GO:0055062)10.7923687
183trivalent inorganic anion homeostasis (GO:0072506)10.7923687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat9.18268321
2TRIM28_21343339_ChIP-Seq_HEK293_Human7.89146866
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.59729770
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.72948917
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.73186169
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.25658314
7GBX2_23144817_ChIP-Seq_PC3_Human2.81492772
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.80205118
9AR_21572438_ChIP-Seq_LNCaP_Human2.78435254
10VDR_22108803_ChIP-Seq_LS180_Human2.69017006
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65845635
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38366537
13LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34826171
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24387145
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12361531
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.02738967
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.00740608
18TP53_16413492_ChIP-PET_HCT116_Human1.96350612
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92084477
20PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.89604908
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84972799
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84972799
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82810817
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82587847
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80361848
26* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80307847
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77315281
28EWS_26573619_Chip-Seq_HEK293_Human1.76123794
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73541991
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71965621
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65975226
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65509586
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65509586
34KDM2B_26808549_Chip-Seq_REH_Human1.60734516
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.60531888
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59453013
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58077530
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51587340
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.47636605
40CLOCK_20551151_ChIP-Seq_293T_Human1.47105794
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.44998001
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44184722
43TP53_18474530_ChIP-ChIP_U2OS_Human1.41823364
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.39664345
45FUS_26573619_Chip-Seq_HEK293_Human1.37462799
46HTT_18923047_ChIP-ChIP_STHdh_Human1.37299359
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35796238
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34073023
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30575364
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30154128
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.29180447
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27160582
53CJUN_26792858_Chip-Seq_BT549_Human1.26689894
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.25633887
55SMAD4_21799915_ChIP-Seq_A2780_Human1.25625422
56SA1_22415368_ChIP-Seq_MEFs_Mouse1.25426119
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24641411
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21703245
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21671739
60CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20646200
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20497674
62* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20418915
63CDX2_22108803_ChIP-Seq_LS180_Human1.20119105
64STAT3_23295773_ChIP-Seq_U87_Human1.19732004
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17571435
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.17021160
67SOX2_20726797_ChIP-Seq_SW620_Human1.16527621
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16444172
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.16374762
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15849384
71AR_25329375_ChIP-Seq_VCAP_Human1.14911980
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14420038
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13952035
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13952035
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13675539
76* SOX2_19829295_ChIP-Seq_ESCs_Human1.13663247
77* NANOG_19829295_ChIP-Seq_ESCs_Human1.13663247
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12800875
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12687453
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11577615
81VDR_24787735_ChIP-Seq_THP-1_Human1.11238636
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10387697
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10324042
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.09919577
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09813791
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09167085
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08423343
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07415035
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07392505
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06687884
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.06014601
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05675178
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.05126820
94STAT1_17558387_ChIP-Seq_HELA_Human1.04891138
95PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03617249
96GATA1_22025678_ChIP-Seq_K562_Human1.02461623
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02313632
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01976159
99HOXB7_26014856_ChIP-Seq_BT474_Human1.01742604
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.01441673
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01323385
102TCF4_23295773_ChIP-Seq_U87_Human1.00841446
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00517749
104AHR_22903824_ChIP-Seq_MCF-7_Human1.00147461
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.99924950
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99744032
107P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99374914
108SOX2_21211035_ChIP-Seq_LN229_Gbm0.98812922
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98785923
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.98047684
111RXR_22108803_ChIP-Seq_LS180_Human0.97775531
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.97581929
113CRX_20693478_ChIP-Seq_RETINA_Mouse0.96834919
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96570905
115SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95668632
116SMAD4_21741376_ChIP-Seq_EPCs_Human0.95361531
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95275726
118SALL4_22934838_ChIP-ChIP_CD34+_Human0.94939344
119* FLI1_21867929_ChIP-Seq_TH2_Mouse0.94426956
120* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94404963
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93806847
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91659392
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91320288
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90892310
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90608100
126* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88523163
127* GATA3_24758297_ChIP-Seq_MCF-7_Human0.88315479
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.88119377
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.87829116
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87528458
131TAF15_26573619_Chip-Seq_HEK293_Human0.87024522
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.86489719
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86251520
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86140124
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85425949
136CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84454556
137EZH2_22144423_ChIP-Seq_EOC_Human0.83719669
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.83678772
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83103072
140SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82480466
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82272902
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79183853
143JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78910357
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78425617
145MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77771011
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.76946490
147BRD4_25478319_ChIP-Seq_HGPS_Human0.76899765
148FLI1_27457419_Chip-Seq_LIVER_Mouse0.76811327
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.76580076
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75496802
151KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74775856
152KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74775856
153KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74775856
154P300_19829295_ChIP-Seq_ESCs_Human0.73288592
155STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.73282732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell6.73909284
2MP0006072_abnormal_retinal_apoptosis4.73562431
3MP0002933_joint_inflammation4.64332236
4MP0004134_abnormal_chest_morphology4.48652811
5MP0002282_abnormal_trachea_morphology4.38516369
6MP0005248_abnormal_Harderian_gland3.79898808
7MP0001963_abnormal_hearing_physiology3.67739778
8MP0000026_abnormal_inner_ear3.36246908
9MP0005503_abnormal_tendon_morphology3.25759895
10MP0000163_abnormal_cartilage_morphology3.22996299
11MP0009780_abnormal_chondrocyte_physiolo3.09690045
12MP0009250_abnormal_appendicular_skeleto2.99966893
13MP0005253_abnormal_eye_physiology2.72674607
14MP0002132_abnormal_respiratory_system2.71642241
15MP0006054_spinal_hemorrhage2.71107296
16MP0002115_abnormal_skeleton_extremities2.64049582
17MP0000762_abnormal_tongue_morphology2.49438416
18MP0000681_abnormal_thyroid_gland2.47756322
19MP0001485_abnormal_pinna_reflex2.41246021
20MP0001299_abnormal_eye_distance/2.27570214
21MP0005508_abnormal_skeleton_morphology2.22477977
22MP0001243_abnormal_dermal_layer2.19145634
23MP0000049_abnormal_middle_ear2.15550605
24MP0002113_abnormal_skeleton_development2.15309049
25MP0005257_abnormal_intraocular_pressure2.10005038
26MP0000013_abnormal_adipose_tissue2.09155451
27MP0002089_abnormal_postnatal_growth/wei2.08797267
28MP0002896_abnormal_bone_mineralization2.04456333
29MP0003942_abnormal_urinary_system2.03994181
30MP0010030_abnormal_orbit_morphology2.03453818
31MP0002233_abnormal_nose_morphology1.99257541
32MP0004885_abnormal_endolymph1.99243856
33MP0009384_cardiac_valve_regurgitation1.98510362
34MP0001533_abnormal_skeleton_physiology1.98425427
35MP0002249_abnormal_larynx_morphology1.96644414
36MP0008438_abnormal_cutaneous_collagen1.92954209
37MP0005390_skeleton_phenotype1.90938146
38MP0001986_abnormal_taste_sensitivity1.87569992
39MP0003880_abnormal_central_pattern1.86275485
40MP0003705_abnormal_hypodermis_morpholog1.82151111
41MP0001270_distended_abdomen1.81464163
42MP0003878_abnormal_ear_physiology1.79959843
43MP0005377_hearing/vestibular/ear_phenot1.79959843
44MP0003123_paternal_imprinting1.78035164
45MP0005275_abnormal_skin_tensile1.77952999
46MP0002116_abnormal_craniofacial_bone1.74300088
47MP0003941_abnormal_skin_development1.71301993
48MP0000534_abnormal_ureter_morphology1.70392480
49MP0002277_abnormal_respiratory_mucosa1.67148082
50MP0002109_abnormal_limb_morphology1.66082714
51MP0004272_abnormal_basement_membrane1.62856412
52MP0002295_abnormal_pulmonary_circulatio1.62774731
53MP0002876_abnormal_thyroid_physiology1.54113971
54MP0003950_abnormal_plasma_membrane1.50853497
55MP0003755_abnormal_palate_morphology1.49195904
56MP0003283_abnormal_digestive_organ1.32163651
57MP0002909_abnormal_adrenal_gland1.31756076
58MP0003795_abnormal_bone_structure1.22372064
59MP0000432_abnormal_head_morphology1.21803980
60MP0008260_abnormal_autophagy1.21126746
61MP0009053_abnormal_anal_canal1.20816210
62MP0000604_amyloidosis1.20133357
63MP0003646_muscle_fatigue1.19877865
64MP0002111_abnormal_tail_morphology1.19400153
65MP0002638_abnormal_pupillary_reflex1.19243122
66MP0002932_abnormal_joint_morphology1.16519180
67MP0003935_abnormal_craniofacial_develop1.13982497
68MP0009333_abnormal_splenocyte_physiolog1.13803984
69MP0004883_abnormal_blood_vessel1.11658298
70MP0005623_abnormal_meninges_morphology1.10599605
71MP0005367_renal/urinary_system_phenotyp1.08554321
72MP0000516_abnormal_urinary_system1.08554321
73MP0003656_abnormal_erythrocyte_physiolo1.08356084
74MP0000537_abnormal_urethra_morphology1.06643220
75MP0000566_synostosis1.05253392
76MP0002168_other_aberrant_phenotype1.03814206
77MP0001286_abnormal_eye_development1.03171761
78MP0001346_abnormal_lacrimal_gland1.02095678
79MP0005391_vision/eye_phenotype0.99934706
80MP0010678_abnormal_skin_adnexa0.99506828
81MP0000751_myopathy0.98476282
82MP0002098_abnormal_vibrissa_morphology0.93967452
83MP0003136_yellow_coat_color0.93072358
84MP0000383_abnormal_hair_follicle0.93070738
85MP0002114_abnormal_axial_skeleton0.90205513
86MP0002060_abnormal_skin_morphology0.89831441
87MP0000428_abnormal_craniofacial_morphol0.88956014
88MP0003938_abnormal_ear_development0.88437776
89MP0003119_abnormal_digestive_system0.88207712
90MP0000372_irregular_coat_pigmentation0.87167776
91MP0004742_abnormal_vestibular_system0.84249277
92MP0001849_ear_inflammation0.82195225
93MP0001919_abnormal_reproductive_system0.81960364
94MP0003011_delayed_dark_adaptation0.81793069
95MP0005164_abnormal_response_to0.81058783
96MP0003385_abnormal_body_wall0.78471765
97MP0001958_emphysema0.78278600
98MP0010234_abnormal_vibrissa_follicle0.77615028
99MP0001191_abnormal_skin_condition0.77522193
100MP0002998_abnormal_bone_remodeling0.76689684
101MP0003937_abnormal_limbs/digits/tail_de0.74696095
102MP0004197_abnormal_fetal_growth/weight/0.74588954
103MP0002108_abnormal_muscle_morphology0.71922028
104MP0005389_reproductive_system_phenotype0.69433607
105MP0003115_abnormal_respiratory_system0.68635096
106MP0005023_abnormal_wound_healing0.67810835
107MP0003448_altered_tumor_morphology0.67399376
108MP0003787_abnormal_imprinting0.65938582
109MP0005381_digestive/alimentary_phenotyp0.65126157
110MP0002837_dystrophic_cardiac_calcinosis0.65013886
111MP0005595_abnormal_vascular_smooth0.64191202
112MP0002234_abnormal_pharynx_morphology0.61681793
113MP0003566_abnormal_cell_adhesion0.61614390
114MP0001663_abnormal_digestive_system0.58711319
115MP0001340_abnormal_eyelid_morphology0.56671987
116MP0004019_abnormal_vitamin_homeostasis0.55910263
117MP0000003_abnormal_adipose_tissue0.55376988
118MP0000733_abnormal_muscle_development0.54914519
119MP0001542_abnormal_bone_strength0.54556661
120MP0001177_atelectasis0.53816537
121MP0001943_abnormal_respiration0.53413466
122MP0001324_abnormal_eye_pigmentation0.53270944
123MP0010771_integument_phenotype0.52549970
124MP0005171_absent_coat_pigmentation0.52164805
125MP0002102_abnormal_ear_morphology0.52084238
126MP0000462_abnormal_digestive_system0.51310822
127MP0003279_aneurysm0.50195791
128MP0000613_abnormal_salivary_gland0.49358060
129MP0000427_abnormal_hair_cycle0.48994203
130MP0004484_altered_response_of0.48657465
131MP0002272_abnormal_nervous_system0.48616235
132MP0005193_abnormal_anterior_eye0.48334897
133MP0005395_other_phenotype0.48277441
134MP0000579_abnormal_nail_morphology0.48104613
135MP0003195_calcinosis0.48037844
136MP0005387_immune_system_phenotype0.48007223
137MP0001790_abnormal_immune_system0.48007223
138MP0004084_abnormal_cardiac_muscle0.46967081
139MP0000367_abnormal_coat/_hair0.46173063
140MP0002128_abnormal_blood_circulation0.45830348
141MP0005408_hypopigmentation0.45253678
142MP0002177_abnormal_outer_ear0.44984191
143MP0001756_abnormal_urination0.43862498
144MP0003763_abnormal_thymus_physiology0.41804924
145MP0004147_increased_porphyrin_level0.41745693
146MP0003936_abnormal_reproductive_system0.41315667
147MP0002396_abnormal_hematopoietic_system0.39739288
148MP0000627_abnormal_mammary_gland0.39279478
149MP0002160_abnormal_reproductive_system0.37771770
150MP0009745_abnormal_behavioral_response0.37178614
151MP0001905_abnormal_dopamine_level0.34768872
152MP0010386_abnormal_urinary_bladder0.34331332
153MP0002938_white_spotting0.33937790
154MP0004133_heterotaxia0.33413773
155MP0005551_abnormal_eye_electrophysiolog0.31323197
156MP0004808_abnormal_hematopoietic_stem0.29483575
157MP0002135_abnormal_kidney_morphology0.29469924
158MP0001944_abnormal_pancreas_morphology0.29066304
159MP0003693_abnormal_embryo_hatching0.28308038
160MP0001175_abnormal_lung_morphology0.27959523

Predicted human phenotypes

RankGene SetZ-score
1Vitreoretinal degeneration (HP:0000655)9.78067537
2Hypoplastic ischia (HP:0003175)7.53715584
3Subacute progressive viral hepatitis (HP:0006572)7.48139275
4Abnormality of the frontal sinuses (HP:0002687)7.00595710
5Spondylolisthesis (HP:0003302)6.94309123
6Aplasia/Hypoplasia involving the sinuses (HP:0009120)6.80677623
7Abnormality of the ischium (HP:0003174)6.67196892
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)6.67097995
9Small epiphyses (HP:0010585)6.29179190
10Genu varum (HP:0002970)5.56983788
11Cupped ribs (HP:0000887)5.27706813
12Mild short stature (HP:0003502)5.27373141
13Flattened epiphyses (HP:0003071)5.18446841
14Delayed epiphyseal ossification (HP:0002663)5.05627281
15Delayed closure of the anterior fontanelle (HP:0001476)5.03066736
16Abnormal tarsal ossification (HP:0008369)4.83580629
17Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.70824088
18Absent epiphyses (HP:0010577)4.70824088
19Persistence of primary teeth (HP:0006335)4.69604193
20Aplasia involving bones of the extremities (HP:0009825)4.69253559
21Aplasia involving bones of the upper limbs (HP:0009823)4.69253559
22Aplasia of the phalanges of the hand (HP:0009802)4.69253559
23Osteoarthritis (HP:0002758)4.62922218
24Severe Myopia (HP:0011003)4.53289937
25Viral hepatitis (HP:0006562)4.38846125
26Flat acetabular roof (HP:0003180)4.38123379
27Pigmentary retinal degeneration (HP:0001146)4.26507208
28Osteolytic defects of the hand bones (HP:0009699)4.17083830
29Osteolytic defects of the phalanges of the hand (HP:0009771)4.17083830
30Abnormality of the vertebral endplates (HP:0005106)4.14604389
31Flat capital femoral epiphysis (HP:0003370)4.12443868
32Micronodular cirrhosis (HP:0001413)4.02211326
33Choroideremia (HP:0001139)3.90700749
34Abnormality of the pubic bones (HP:0003172)3.89533288
35Protuberant abdomen (HP:0001538)3.84742990
36Abnormality of the vitreous humor (HP:0004327)3.81757399
37Neonatal short-limb short stature (HP:0008921)3.78170379
38Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.78036532
39Abnormality of femoral epiphyses (HP:0006499)3.78036532
40Enlarged epiphyses (HP:0010580)3.67650268
41Hepatocellular carcinoma (HP:0001402)3.63533900
42Arthropathy (HP:0003040)3.60513012
43Abnormal foot bone ossification (HP:0010675)3.48049583
44Abnormality of the epiphysis of the femoral head (HP:0010574)3.37143664
45Platyspondyly (HP:0000926)3.33265044
46Delayed cranial suture closure (HP:0000270)3.30667362
47Vertebral clefting (HP:0008428)3.29386097
48Metaphyseal cupping (HP:0003021)3.25006668
49Partial duplication of the phalanx of hand (HP:0009999)3.21566934
50Cervical subluxation (HP:0003308)3.18375208
51Asymmetry of the thorax (HP:0001555)3.14562146
52Glossoptosis (HP:0000162)3.13421773
53Mixed hearing impairment (HP:0000410)3.09865472
54Abnormality of the femoral head (HP:0003368)3.08627475
55Ridged nail (HP:0001807)3.03579662
56Tibial bowing (HP:0002982)3.00709001
57Metaphyseal dysplasia (HP:0100255)2.99794062
58Exostoses (HP:0100777)2.96866471
59Transitional cell carcinoma of the bladder (HP:0006740)2.94843039
60Short femoral neck (HP:0100864)2.92430546
61Femoral bowing (HP:0002980)2.91554995
62Uterine leiomyosarcoma (HP:0002891)2.88797319
63Leiomyosarcoma (HP:0100243)2.88797319
64Wormian bones (HP:0002645)2.87788778
65Partial duplication of thumb phalanx (HP:0009944)2.84784524
66Premature rupture of membranes (HP:0001788)2.84109629
67Metaphyseal irregularity (HP:0003025)2.78390467
68Ulnar bowing (HP:0003031)2.78380803
69Peritonitis (HP:0002586)2.77876513
70Infantile muscular hypotonia (HP:0008947)2.76258269
71Short middle phalanx of the 5th finger (HP:0004220)2.74227064
72Abnormality of primary teeth (HP:0006481)2.71479399
73Bladder carcinoma (HP:0002862)2.65945930
74Bladder neoplasm (HP:0009725)2.65945930
75Protrusio acetabuli (HP:0003179)2.65034882
76Abnormal vertebral ossification (HP:0100569)2.64675689
77Coxa vara (HP:0002812)2.64417058
78Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.64333483
79Decreased skull ossification (HP:0004331)2.62789222
80Thoracolumbar scoliosis (HP:0002944)2.60192141
81Micromelia (HP:0002983)2.58801321
82Irregular vertebral endplates (HP:0003301)2.58722961
83Aplasia/Hypoplasia of the fibula (HP:0006492)2.56325827
84Abnormality of the phalanges of the 2nd finger (HP:0009541)2.54892616
85Mesangial abnormality (HP:0001966)2.52920694
86Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.49110202
87Anomalous pulmonary venous return (HP:0010772)2.46181403
88Wide anterior fontanel (HP:0000260)2.45378487
89Waddling gait (HP:0002515)2.44055276
90Hepatitis (HP:0012115)2.42139038
91Barrel-shaped chest (HP:0001552)2.41748492
92Abnormality of incisor morphology (HP:0011063)2.41634591
93Narrow palate (HP:0000189)2.40869583
94Aplasia/Hypoplasia of the scapulae (HP:0006713)2.39751353
95Hypoplastic scapulae (HP:0000882)2.39751353
96Decreased lacrimation (HP:0000633)2.38817009
97Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.37940764
98Thin ribs (HP:0000883)2.37215345
99Radial bowing (HP:0002986)2.36199380
100Beaking of vertebral bodies (HP:0004568)2.35380828
101Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.34178041
102Abnormality of the proximal phalanges of the hand (HP:0009834)2.27298113
103Alacrima (HP:0000522)2.24965599
104Thickened calvaria (HP:0002684)2.24906034
105Lumbar hyperlordosis (HP:0002938)2.24274081
106Neoplasm of the liver (HP:0002896)2.23609477
107Abnormality of carpal bone ossification (HP:0006257)2.23327256
108Abnormality of the peritoneum (HP:0002585)2.23191498
109Absent frontal sinuses (HP:0002688)2.22873117
110Abnormality of skull ossification (HP:0002703)2.22038419
111Craniofacial hyperostosis (HP:0004493)2.20620452
112Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.20299747
113Vertebral hypoplasia (HP:0008417)2.20299747
114Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.17459349
115Hypoplastic ilia (HP:0000946)2.16663923
116Bell-shaped thorax (HP:0001591)2.16023566
117Duplication of thumb phalanx (HP:0009942)2.15396751
118Genu valgum (HP:0002857)2.13761252
119Ulnar claw (HP:0001178)2.12373896
120Abnormality of the pulmonary veins (HP:0011718)2.11883732
121Ovoid vertebral bodies (HP:0003300)2.11641687
122Abnormality of the 2nd finger (HP:0004100)2.10394134
123Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.08782549
124Abnormality of the middle phalanges of the hand (HP:0009833)2.08564746
125Limited hip movement (HP:0008800)2.08160654
126Aplasia/hypoplasia of the femur (HP:0005613)2.07222322
127Sprengel anomaly (HP:0000912)2.07085865
128Hip contracture (HP:0003273)2.06456907
129Hypoplastic pelvis (HP:0008839)2.05636859
130Limited elbow extension (HP:0001377)2.05605797
131Fibular hypoplasia (HP:0003038)2.05396424
132Rhizomelia (HP:0008905)2.02120488
133Arterial tortuosity (HP:0005116)2.00575409
134Cranial hyperostosis (HP:0004437)2.00458797
135Epiphyseal dysplasia (HP:0002656)12.4770102
136Irregular epiphyses (HP:0010582)10.1313085
137Hypoplasia of the odontoid process (HP:0003311)1.98676406
138Abnormality of the lumbar spine (HP:0100712)1.97721834
139Increased corneal curvature (HP:0100692)1.97358265
140Keratoconus (HP:0000563)1.97358265
141Atrophic scars (HP:0001075)1.96897438
142Fragile skin (HP:0001030)1.96625217
143Flared metaphyses (HP:0003015)1.93303414
144Long clavicles (HP:0000890)1.91624056
145Stillbirth (HP:0003826)1.90959480
146Soft skin (HP:0000977)1.88663537
147Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88348243
148Hyperextensible skin (HP:0000974)1.88187656
149Abnormality of the phalanges of the 5th finger (HP:0004213)1.85967534
150Aortic dissection (HP:0002647)1.85206230
151Abnormal hand bone ossification (HP:0010660)1.84541233
152Gastrointestinal carcinoma (HP:0002672)1.84003653
153Malignant gastrointestinal tract tumors (HP:0006749)1.84003653
154Nonimmune hydrops fetalis (HP:0001790)1.81575168
155Synostosis of carpal bones (HP:0005048)1.80973922
156Mesomelia (HP:0003027)1.80644408
157Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78206500
158Abnormal ossification of hand bones (HP:0005921)1.78008848
159Short ribs (HP:0000773)1.77970265
160Conical tooth (HP:0000698)1.77545368
161Vascular tortuosity (HP:0004948)1.75095482
162Disproportionate short-trunk short stature (HP:0003521)1.74807609
163Systemic lupus erythematosus (HP:0002725)1.74615747
164Biconcave vertebral bodies (HP:0004586)1.74049231
165Spinal cord compression (HP:0002176)1.73830256
166Short middle phalanx of finger (HP:0005819)1.72466146
167Broad phalanx (HP:0006009)1.70967684
168Carpal bone hypoplasia (HP:0001498)1.67925628
169Abdominal distention (HP:0003270)1.67336170
170Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.67170045
171Abnormality of the acetabulum (HP:0003170)1.66608300
172Patent foramen ovale (HP:0001655)1.65311843
173Short palm (HP:0004279)1.62047467
174Abnormality of the odontoid process (HP:0003310)1.60689122
175Broad long bones (HP:0005622)1.59550571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.75430407
2MAP3K33.89635534
3VRK23.08112841
4IRAK12.87983224
5STK38L2.87451851
6MAP3K122.83309872
7LATS12.79625700
8NME12.62673330
9TRPM72.53269794
10ERBB32.45777553
11SGK22.45741030
12ADRBK22.30536522
13TRIB32.26109514
14STK242.17157932
15FGFR22.06714954
16MUSK2.03530342
17DDR212.5572737
18PRKD31.87162407
19MAP3K131.86257333
20TNIK1.85545918
21SGK31.84206384
22TYK21.81884043
23IRAK21.80382141
24MST41.77084601
25SGK2231.71551072
26SGK4941.71551072
27STK391.65878797
28PRKG21.60915412
29PLK21.58522773
30PKN21.55393942
31MAP3K71.49307427
32CAMK41.46844938
33EPHA31.42942079
34STK31.37930540
35MARK21.32967626
36VRK11.32946876
37WNK41.32816178
38TAF11.23260874
39NUAK11.16018848
40WNK31.14019012
41NTRK11.08454889
42TAOK31.04733749
43EPHB21.03029249
44HIPK20.98451450
45MET0.97989235
46MAPKAPK50.97718472
47BMPR20.91485643
48PIM20.91480514
49MAP3K20.89960355
50DYRK1A0.86717225
51NTRK30.84814392
52CDC42BPA0.84732775
53PKN10.83166043
54PDK20.83096503
55OXSR10.82066783
56CDK40.79621583
57PTK60.78854359
58SIK10.77857570
59DYRK1B0.76921785
60KSR10.75172674
61CAMK2D0.74803115
62ZAK0.74795432
63MKNK20.69167816
64CAMK2G0.69086647
65LRRK20.67796362
66PAK30.65759030
67ADRBK10.64956909
68RPS6KA50.62767453
69RIPK10.62723789
70TAOK10.61626541
71GSK3A0.60998235
72MARK30.60046293
73CDK60.59812801
74CSNK1G10.58529062
75NEK60.58002006
76FER0.56402593
77CSNK1A1L0.56351634
78EPHB10.56031718
79PRKCH0.53496615
80STK380.51248680
81LATS20.51241467
82FGFR10.50615696
83PAK40.49994247
84PDGFRA0.49293417
85MST1R0.48834683
86MAPK150.48268176
87CDK90.48120500
88MAP3K10.47737986
89CAMK10.46977490
90CAMK2A0.46903774
91ILK0.45234363
92RPS6KA40.45135364
93CSNK1A10.44212214
94JAK10.43212923
95PAK60.42543792
96MKNK10.42325762
97EIF2AK30.42114051
98IKBKB0.41574865
99GRK50.40184964
100ROCK10.39629067
101MAPK70.39380565
102MAPK40.39190190
103PTK2B0.37918614
104SMG10.37910749
105ATM0.37005714
106PAK20.36768994
107ALK0.36192108
108MAPK120.36125854
109WNK10.35902390
110LMTK20.35893829
111MAP3K100.35131901
112SGK10.35086860
113CSNK1G20.34183737
114GRK10.33797098
115PASK0.33633139
116CSNK1G30.32330691
117RET0.31736153
118ROCK20.31618912
119PRKAA20.31611587
120CDK80.30844610
121PRKCE0.29464539
122CAMKK10.28966133
123ATR0.28713567
124TGFBR10.27978168
125BCR0.27495448
126PIK3CA0.26785367
127CHUK0.26503381
128WEE10.26482182
129PDK10.26288402
130MAPKAPK20.26232513
131KSR20.25533464
132MAP2K60.25222281
133PTK20.25117847
134INSRR0.24956756
135BMX0.24587039
136MYLK0.24532454
137EPHA40.24404598
138TESK10.24386959
139MAP2K40.24377812
140CAMKK20.24335122
141MELK0.24186763
142BRSK20.23420948
143ERBB20.22605644
144ABL10.22596191
145PRKD10.22258220
146PRKCZ0.21245257
147DAPK10.20901612
148CSK0.20666613
149PLK30.20510627
150CSNK1D0.20498826
151MAP2K10.20400108
152TGFBR20.20398696
153FGFR40.20201400
154UHMK10.19268028
155PDGFRB0.18777375
156CDK50.18559915
157FGFR30.16596102
158NLK0.16043597
159PRKD20.15656492
160MAP3K50.15301925
161FLT30.14813752
162PRKCG0.14724081
163LIMK10.14422412
164MAP3K110.13656882
165PRKCD0.13384219
166PHKG10.12954012
167PHKG20.12954012

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein digestion and absorption_Homo sapiens_hsa049746.12145783
2ECM-receptor interaction_Homo sapiens_hsa045125.94426786
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.86592309
4Homologous recombination_Homo sapiens_hsa034403.29009038
5Mismatch repair_Homo sapiens_hsa034303.12585452
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.74403875
7Basal cell carcinoma_Homo sapiens_hsa052172.50052454
8Focal adhesion_Homo sapiens_hsa045102.43933354
9Hippo signaling pathway_Homo sapiens_hsa043902.26573742
10TGF-beta signaling pathway_Homo sapiens_hsa043502.13338053
11Sulfur metabolism_Homo sapiens_hsa009202.05800576
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97605763
13Wnt signaling pathway_Homo sapiens_hsa043101.87278066
14Fanconi anemia pathway_Homo sapiens_hsa034601.83094756
15Phenylalanine metabolism_Homo sapiens_hsa003601.78710516
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71025694
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.68251986
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.63548897
19Nucleotide excision repair_Homo sapiens_hsa034201.61311457
20Proteoglycans in cancer_Homo sapiens_hsa052051.59979853
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58346859
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.56463631
23Hedgehog signaling pathway_Homo sapiens_hsa043401.55251511
24Histidine metabolism_Homo sapiens_hsa003401.53276486
25DNA replication_Homo sapiens_hsa030301.39188933
26Complement and coagulation cascades_Homo sapiens_hsa046101.37279953
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36805497
28Sphingolipid metabolism_Homo sapiens_hsa006001.30201778
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27490143
30Melanogenesis_Homo sapiens_hsa049161.21626010
31Retinol metabolism_Homo sapiens_hsa008301.21613652
32beta-Alanine metabolism_Homo sapiens_hsa004101.18779360
33Glutathione metabolism_Homo sapiens_hsa004801.18026943
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17490326
35Starch and sucrose metabolism_Homo sapiens_hsa005001.11112690
36Folate biosynthesis_Homo sapiens_hsa007901.10946992
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08880338
38Steroid biosynthesis_Homo sapiens_hsa001001.06175061
39Arachidonic acid metabolism_Homo sapiens_hsa005901.05121331
40ABC transporters_Homo sapiens_hsa020101.00077234
41Olfactory transduction_Homo sapiens_hsa047400.97876997
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97776200
43Other glycan degradation_Homo sapiens_hsa005110.95491718
44Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95288858
45Rheumatoid arthritis_Homo sapiens_hsa053230.94376636
46Colorectal cancer_Homo sapiens_hsa052100.93133681
47Dorso-ventral axis formation_Homo sapiens_hsa043200.92158828
48Nitrogen metabolism_Homo sapiens_hsa009100.91690557
49Pertussis_Homo sapiens_hsa051330.91503606
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90789687
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89204031
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86836785
53Malaria_Homo sapiens_hsa051440.85978179
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83594108
55Phototransduction_Homo sapiens_hsa047440.83205447
56Ovarian steroidogenesis_Homo sapiens_hsa049130.83093845
57Ether lipid metabolism_Homo sapiens_hsa005650.82404485
58Dilated cardiomyopathy_Homo sapiens_hsa054140.81849010
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80609502
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80290330
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78977846
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77615505
63Type II diabetes mellitus_Homo sapiens_hsa049300.76668745
64Renal cell carcinoma_Homo sapiens_hsa052110.75106788
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72776974
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72608173
67Lysine degradation_Homo sapiens_hsa003100.72490010
68Axon guidance_Homo sapiens_hsa043600.70761785
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70619312
70Arginine and proline metabolism_Homo sapiens_hsa003300.69983247
71Vibrio cholerae infection_Homo sapiens_hsa051100.68962818
72Adherens junction_Homo sapiens_hsa045200.68438496
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65902281
74Protein export_Homo sapiens_hsa030600.65223220
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63741973
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62644692
77Amoebiasis_Homo sapiens_hsa051460.62583012
78Staphylococcus aureus infection_Homo sapiens_hsa051500.62179635
79p53 signaling pathway_Homo sapiens_hsa041150.61803238
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.61675419
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61662795
82Platelet activation_Homo sapiens_hsa046110.60421748
83Osteoclast differentiation_Homo sapiens_hsa043800.60314780
84Long-term depression_Homo sapiens_hsa047300.57176975
85Insulin resistance_Homo sapiens_hsa049310.56997368
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55779142
87Lysosome_Homo sapiens_hsa041420.55194843
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54602888
89Tyrosine metabolism_Homo sapiens_hsa003500.54040596
90Chronic myeloid leukemia_Homo sapiens_hsa052200.52800185
91Selenocompound metabolism_Homo sapiens_hsa004500.51758686
92Thyroid hormone synthesis_Homo sapiens_hsa049180.50929601
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49719995
94Bladder cancer_Homo sapiens_hsa052190.49680770
95Gap junction_Homo sapiens_hsa045400.48936789
96Melanoma_Homo sapiens_hsa052180.48405683
97Endometrial cancer_Homo sapiens_hsa052130.48223323
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.47723706
99Chemical carcinogenesis_Homo sapiens_hsa052040.47430490
100Prostate cancer_Homo sapiens_hsa052150.46751505
101Glioma_Homo sapiens_hsa052140.46384880
102Caffeine metabolism_Homo sapiens_hsa002320.44947433
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44816365
104Tight junction_Homo sapiens_hsa045300.44799752
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42638152
106MAPK signaling pathway_Homo sapiens_hsa040100.42629261
107Pathways in cancer_Homo sapiens_hsa052000.42417466
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42116736
109Thyroid cancer_Homo sapiens_hsa052160.40878794
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.40809938
111ErbB signaling pathway_Homo sapiens_hsa040120.40131444
112Estrogen signaling pathway_Homo sapiens_hsa049150.39622380
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39234104
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39153536
115Fatty acid biosynthesis_Homo sapiens_hsa000610.39033725
116Toxoplasmosis_Homo sapiens_hsa051450.38832593
117FoxO signaling pathway_Homo sapiens_hsa040680.36947567
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36278157
119N-Glycan biosynthesis_Homo sapiens_hsa005100.35222949
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34977799
121Propanoate metabolism_Homo sapiens_hsa006400.34526499
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34519872
123Linoleic acid metabolism_Homo sapiens_hsa005910.34372812
124Salivary secretion_Homo sapiens_hsa049700.34068680
125MicroRNAs in cancer_Homo sapiens_hsa052060.33013260
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.32550864
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32025390
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.31120315
129Phagosome_Homo sapiens_hsa041450.30984354
130Oxytocin signaling pathway_Homo sapiens_hsa049210.30699346
131Circadian entrainment_Homo sapiens_hsa047130.30680901
132Amphetamine addiction_Homo sapiens_hsa050310.30125212
133Rap1 signaling pathway_Homo sapiens_hsa040150.29706245
134Ras signaling pathway_Homo sapiens_hsa040140.29466336
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29380480
136AMPK signaling pathway_Homo sapiens_hsa041520.29056671
137Apoptosis_Homo sapiens_hsa042100.28666648
138mTOR signaling pathway_Homo sapiens_hsa041500.28259440
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27900728
140Cocaine addiction_Homo sapiens_hsa050300.27888205
141Small cell lung cancer_Homo sapiens_hsa052220.27846729
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27759861
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.27345832
144Pancreatic cancer_Homo sapiens_hsa052120.26940555
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26877903
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.26480287
147Arginine biosynthesis_Homo sapiens_hsa002200.24509891
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23225796
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.23073677
150Hematopoietic cell lineage_Homo sapiens_hsa046400.22767927
151Measles_Homo sapiens_hsa051620.22042777
152Tryptophan metabolism_Homo sapiens_hsa003800.21742258
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.20719880
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19002245
155Choline metabolism in cancer_Homo sapiens_hsa052310.17568175

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